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Marisa Marques got the BSc degree in Biochemistry in 2012 followed by the MSc degree in Biochemistry in 2013, both at the Faculty of Sciences and Technology, University of Coimbra, Portugal. On her thesis project, entitled “Autophagy in cortical neurons: role of caloric restriction and neuropeptide Y”, Marisa developed important work to clarify the mechanisms underlying the anti-aging effects of caloric restriction, moreover, it allowed the identification of potential therapeutic targets for the aging and age-related diseases. In the same year, she received a research fellowship to work at Neuroendocrinology and Aging group, Center for Neuroscience and Cell Biology, University of Coimbra, in a project entitled “Pre-clinical study of depression in unpredictable chronic stress model”. In 2014, she got a FCT research fellowship to work at Cell Metabolism and Quality Control Group, Center for Neuroscience and Cell Biology, University of Coimbra, in the project entitled “Tackling Alzheimer’s Disease with a new peptide inhibitor of BACE1” and she is one of the inventors of an international patent application that is now pending in Portugal: “Peptide inhibitors of BACE1 for the treatment of neurological disorders” (International publication number: WO2017/095250 A1). In 2016, she was involved in a research project, supported by American Progeria Research Foundation that studied different therapeutic approaches to delay the aging process of normal and premature aging diseases, in particular Hutchinson-Gilford progeria syndrome, under Célia Aveleira and Cláudia Cavadas supervision at the Neuroendocrinology and Aging Group at Center for Neuroscience and Cell Biology, University of Coimbra. Currently, Marisa is under a PhD fellowship supported by Fundação para a Ciência e a Tecnologia (FCT) (Reference: SFRH/BD/120023/2016), entitled “Neuropeptide Y (NPY) system as a new target to delay aging” under the supervision of Cláudia Cavadas, Xavier Nissan and Célia Aveleira. She spent 5 months at the I-Stem Institute - Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, France, to developed complementary studies for her PhD project. Marisa Ferreira-Marques was also involved in the laboratory supervision of several laboratory rotations and master’s students and participated in various activities regarding science communication. So far Marisa is the first author of a scientific article in international peer-reviewed journal, and co-author of 3 scientific articles in international peer-reviewed journals.
Identificação

Identificação pessoal

Nome completo
Marisa Ferreira-Marques

Nomes de citação

  • Ferreira-Marques, Marisa

Identificadores de autor

Ciência ID
EA15-6C9F-F15E
ORCID iD
0000-0002-8740-6411
Google Scholar ID
https://scholar.google.pt/citations?hl=pt-PT&user=ffCyeDAAAAAJ

Endereços de correio eletrónico

  • marisa.marques@student.uc.pt (Profissional)
  • mrsmrqs89@gmail.com (Pessoal)

Telefones

Telefone
  • 239820190 (Profissional)

Moradas

  • Center for Neuroscience and Cell Biology | University of Coimbra. Universidade de Coimbra, Rua Larga, Edifício FMUC, 1.º piso, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Clínica - Endocrinologia e Metabolismo
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Patologia
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1)
Formação
Grau Classificação
2016/09 - 2021/08
Em curso
Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Neuropeptide Y (NPY) system as a new target to delay aging" (TESE/DISSERTAÇÃO)
2014/02/01 - 2014/02/28
Concluído
Course on Laboratory Animal Science - FELASA B Level (Outros)
Especialização em FELASA B Level
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013
Concluído
Mestrado em Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
""Autophagy in cortical neurons: role of caloric restriction and neuropeptide Y"" (TESE/DISSERTAÇÃO)
Seventeen (17/20)
2012
Concluído
Licenciatura em Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"''Evaluation of the toxicity and anti-proliferative capacity of gambogic acid''" (TESE/DISSERTAÇÃO)
Thirteen (13/20)
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2017/03/01 - Atual PhD student in Pharmaceutical Sciences, (FCT Reference: SFRH/BD/120023/2016), under the supervision of Cláudia Cavadas, Xavier Nissan and Célia Aveleira. Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
(...)
2020/03 - 2020/06 Research volunteer task force COVID-19. Universidade de Coimbra, Portugal
2019/10 - 2020/02 PhD student visiting I-Stem (Institute for Stem Cell Therapy and Exploration of Monogenic Diseases), France, under the supervision of Xavier Nissan (FCT Reference: SFRH/BD/120023/2016). I-Stem, França
2016/04/01 - 2017/02/28 Research fellow in the project “Ghrelin: a novel therapeutic intervention to rescue the phenotype of Hutchinson-Gilford Progeria Syndrome”, funded by American Progeria Research Foundation. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/01/01 - 2016/03/31 Research fellow in continuation of the project “Tackling Alzheimer’s Disease with a new peptide inhibitor of BACE1”, supported by University of Coimbra. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/05/15 - 2015/11/30 Research fellow in the project “Tackling Alzheimer’s Disease with a new peptide inhibitor of BACE1”, supported by FCT, Portugal (PTDC/NEU-SCC/1351/2012). Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/01 - 2014/05 Voluntary researcher in continuation of Master’s research on project, under Célia Aveleira and Cláudia Cavadas supervision. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/10/01 - 2013/12/31 Research fellow in the project “Pre-clinical study of depression in unpredictable chronic stress model”, supported by Tecnimede, Portugal (Ref:Tec1_2013). Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/09/01 - 2013/09/18 Master student with thesis theme: “Autophagy in cortical neurons: role of caloric restriction and neuropeptide Y” (19, nineteen), under the supervision of Célia Aveleira and Cláudia Cavadas. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/02/28 - 2011/07/29 Bachelor degree with scientific research project entitled "Evaluation of the toxicity and anti-proliferative capacity of gambogic acid" (17, seventeen), under the supervision of Ana Bela Sarmento. Universidade de Coimbra Faculdade de Medicina, Portugal
Projetos

Outro

Designação Financiadores
2018 - 2021/05/31 NiNjA - New Neuroendocrine Strategy for healthy Aging
PTDC/MED-FAR/30167/2017
Outra
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2015 - 2017/06/30 Peripheral NPY reverts HGPS phenotype: a study in human fibroblasts and mouse models
PRF2015-60
Outra
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Progeria Research Foundation
2015 - 2016/12/31 Ghrelin: a novel therapeutic intervention to rescue the phenotype of HGPS
PRF2014-53
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Progeria Research Foundation
2014 - 2015/11 Tackling Alzheimer’s disease with a new peptide inhibitor of BACE1
PTDC/NEU-SCC/1351/2012
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2013 - 2013/12 Pre-clinical study of depression in unpredictable chronic stress model
Tec1_2013
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Grupo Tecnimede
Produções

Publicações

Artigo em conferência
  1. Cavadas, Claudia; Ferreira-Marques, Marisa; Carmo-Silva, Sara; Botelho, Mariana; Aveleira, Célia. "Neuropeptide Y stimulates autophagy in hypothalamic neurons". Trabalho apresentado em 30th ECNP Congress, Paris, 2017.
    Publicado • 10.1016/s0924-977x(17)31002-7
  2. Botelho, Mariana; Aveleira, Célia; Carmo-Silva, Sara; Pascoal, Jorge; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". Trabalho apresentado em 11th NPY-PYY-PP International Meeting, Leipzig, 2016.
    Publicado • 10.1016/j.npep.2015.11.035
  3. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Pereira, Cláudia; Santos, Armanda. "New BACE1 inhibitors decrease Aß production in cellular and in vivo models of Alzheimer's disease". Trabalho apresentado em 30ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência, Lisbon, 2016.
    Publicado
  4. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda. "New promising peptides to inhibit BACE1: evaluation of compound efficiency in cellular and mouse models of Alzheimer’s disease". Trabalho apresentado em 29ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência, Aveiro, 2015.
    Publicado
Artigo em revista
  1. Ferreira-Marques, Marisa; Carvalho, André; Cavadas, Claudia; Aveleira, Célia. "PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons". Aging (2021): https://doi.org/10.18632/aging.202805.
    10.18632/aging.202805
  2. Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patricia; Coimbra, Judite RM; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge; et al. "New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPP-ß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer's Disease Models". Journal of Alzheimer's Disease (2020): http://doi.org/10.3233/JAD-200381.
    10.3233/JAD-200381
  3. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells". The Journals of Gerontology: Series A (2020): http://dx.doi.org/10.1093/gerona/glz280.
    Acesso aberto • Publicado • 10.1093/gerona/glz280
  4. Ferreira-Marques, Marisa; Aveleira, Célia; Carmo-Silva, Sara; Botelho, Mariana; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation". Aging 8 7 (2016): 1470-1484. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014143445&partnerID=MN8TOARS.
    Publicado • 10.18632/aging.100996
  5. Aveleira, Célia; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, J.F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al. "Neuropeptide Y stimulates autophagy in hypothalamic neurons". Proceedings of the National Academy of Sciences of the United States of America 112 13 (2015): E1642-E1651. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926180461&partnerID=MN8TOARS.
    Publicado • 10.1073/pnas.1416609112
  6. Santana, Magda; Rosmaninho-Salgado, Joana; Cortez, Vera; Pereira, Frederico; Kaster, Manuella; Aveleira, Célia; Ferreira-Marques, Marisa; Álvaro, Ana Rita (3011-2121-D4F8); Cavadas, Claudia. "Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress". European Neuropsychopharmacology 25 10 (2015): 1753-1766. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943267584&partnerID=MN8TOARS.
    Publicado • 10.1016/j.euroneuro.2015.06.013
Poster em conferência
  1. Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "Targeting the neuroendocrine system to delay aging phenotype in Progeria". Trabalho apresentado em Centre of Innovative Biomedicine and Biotechnology (CIBB) Annual Meeting 2019, University of Coimbra, Coimbra, Portugal, 2019.
  2. Franco, Ana Catarina; Ferreira-Marques, Marisa; Carvalho, André; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "A neuroendocrine strategy to slow down the clock on skin aging". Trabalho apresentado em BEB day 2019, University of Coimbra, Coimbra, Portugal, 2019.
  3. Franco, Ana Catarina; Ferreira-Marques, Marisa; Carvalho, André; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "Neuroendocrine peptide as a novel therapeutic strategy to delay skin aging". Trabalho apresentado em Poster presented at the Centre of Innovative Biomedicine and Biotechnology (CIBB) Annual Meeting 2019, University of Coimbra, Coimbra, Portugal, 2019.
  4. Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "Neuroendocrine peptide as a novel strategy to delay aging in HGPS". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, Faculty of Pharmacy of the University of Coimbra, Coimbra, Portugal, 2019.
  5. Franco, Ana Catarina; Ferreira-Marques, Marisa; Carvalho, André; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "Neuroendocrine peptide as a novel strategy to delay skin aging". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, Faculty of Pharmacy of the University of Coimbra, Coimbra, Portugal, 2019.
  6. Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "A new neuroendocrine strategy to delay aging in HGPS". Trabalho apresentado em 3rd Molecular Biology of Ageing Meeting, Groningen, The Netherlands, 2019.
  7. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y enhances progerin clearance and delays cellular senescence in human Hutchinson-Gilford Progeria Syndrome cells". Trabalho apresentado em 3rd Molecular Biology of Ageing Meeting, Groningen, The Netherlands, 2019.
  8. Ferreira-Marques, Marisa; Carvalho, André; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "Hutchinson-Gilford Progeria Syndrome (HGPS): exploring a neuroendocrine strategy to delay aging". Trabalho apresentado em Ageing: Models, Mechanisms and Therapies Conference, University of Coimbra, Coimbra, Portugal, 2019.
  9. Franco, Ana Catarina; Ferreira-Marques, Marisa; Carvalho, André; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "Ghrelin as a potential therapeutic strategy to delay skin aging and hair loss in Hutchinson-Gilford Progeria Syndrome". Trabalho apresentado em Ageing: Models, Mechanisms and Therapies Conference, University of Coimbra, Coimbra, Portugal, 2019.
  10. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y ameliorates the aging phenotype of Hutchinson-Gilford Progeria Syndrome cells". Trabalho apresentado em Ageing: Models, Mechanisms and Therapies Conference, University of Coimbra, Coimbra, Portugal, 2019.
  11. Ferreira, Inês Dinis; Ferreira-Marques, Marisa; Carvalho, André; Carmo-Silva, Sara; Botelho, Mariana; Aveleira, Célia; Cavadas, Claudia. "Gut alterations in a mouse model of Progeria". Trabalho apresentado em Ageing: Models, Mechanisms and Therapies Conference, University of Coimbra, Coimbra, Portugal, 2019.
  12. Fernandes, Ana Rita; Carmo-Silva, Sara; Babková, Marie; Ferreira-Marques, Marisa; Cavadas, Claudia. "From obesity to aging: studying the effect of poly-saturated fatty acids on circadian rhythm". Trabalho apresentado em Ageing: Models, Mechanisms and Therapies Conference, University of Coimbra, Coimbra, Portugal, 2019.
  13. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2". Trabalho apresentado em Gordon Conference on Clocks in Model Organisms: Circadian Networks, Physiology and Heath, Spain, 2019.
  14. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2". Trabalho apresentado em Gordon Research Seminar on Clocks in Model Organisms: Circadian Networks, Physiology and Heath, Spain, 2019.
  15. Ferreira-Marques, Marisa; Carvalho, André; Carmo-Silva, Sara; Botelho, Mariana; Cavadas, Claudia; Aveleira, Célia. "A new neuroendocrine strategy to delay aging in Hutchinson-Gilford Progeria Syndrome". Trabalho apresentado em 1st Neuroscience and Disease Retreat of the Center of Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal, 2019.
  16. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Aveleira, Célia; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Hypothalamic ataxin-2 a novel regulator of circadian rhythm". Trabalho apresentado em EMBO | EMBL Symposium - Biological Oscillators: Design, Mechanism, Function, Heidelberg, Germany, 2018.
  17. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, Francisco; Sereno, José; Abrunhosa, Antero; Branco, Miguel Castelo; Pereira, Cláudia; Santos, Armanda. "New BACE1 inhibitors decrease Aß production and accumulation in the 3xtg-AD mouse model". Trabalho apresentado em 13th International Conference on Alzheimer’s and Parkinson’s Diseases, Vienna, Austria, 2017.
  18. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, Francisco; Sereno, José; Abrunhosa, Antero; Branco, Miguel Castelo; Pereira, Cláudia; Santos, Armanda. "New BACE1 inhibitors decrease Aß production and accumulation in the 3xtg-AD mouse model". Trabalho apresentado em XIX Congress of the Portuguese Biochemical Society, Guimarães, Portugal, 2016.
  19. Ferreira-Marques, Marisa; Aveleira, Célia; Botelho, Mariana; Carmo-Silva, Sara; Cavadas, Claudia. "Ghrelin mediates caloric restriction-induced autophagy in rat cortical neurons". Trabalho apresentado em 1st Symposium on Aging Research @CNC, University of Coimbra, Coimbra, Portugal, 2016.
  20. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Pereira, Cláudia; Santos, Armanda. "New BACE1 inhibitors decrease Aß production and accumulation in the 3xTg-AD mouse model". Trabalho apresentado em 1st Symposium on Aging Research @CNC, University of Coimbra, Coimbra, Portugal, 2016.
  21. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Aveleira, Célia; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Hypothalamic ataxin-2: a new player in central regulation of energy balance". Trabalho apresentado em EMBO Workshop – Neural control of metabolism and eating behaviour, Cascais, Portugal, 2016.
  22. Aveleira, Célia; Cortes, Luísa; Ferreira-Marques, Marisa; Leal, Ana; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Ghrelin enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells". Trabalho apresentado em The Progeria Research Foundation 8th International Scientific Workshop - Across the Table, Around the Globe, Cambridge, MA, USA, 2016.
  23. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Aveleira, Célia; Álvaro, Ana Rita ; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Ataxin-2 in the hypothalamus: a novel regulator of energy balance and metabolism". Trabalho apresentado em XIII CNC Annual Meeting, University of Coimbra, Coimbra, Portugal, 2015.
  24. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda. "New BACE1 inhibitors for Alzheimer’s Disease treatment". Trabalho apresentado em 19th European Symposium of Organic Chemistry, Lisbon, Portugal, 2015.
  25. Aveleira, Célia; Carmo-Silva, Sara; Botelho, Mariana; Ferreira-Marques, Marisa; Nóbrega, Clévio; López-Otín, Carlos; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging". Trabalho apresentado em The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, Sunday River, Newry, USA, 2015.
  26. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Álvaro, Ana Rita ; Aveleira, Célia; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Impact of hypothalamic ataxin-2 on energy balance and metabolic profile". Trabalho apresentado em 9th World Congress International Brain Research Organization, Rio de Janeiro, Brazil, 2015.
  27. Aveleira, Célia; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al. "Autophagy in the hypothalamus: the role of Neuropeptide Y". Trabalho apresentado em 9th World Congress International Brain Research Organization, Rio de Janeiro, Brazil, 2015.
  28. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda. "Tackling Alzheimer’s disease with a new inhibitor of BACE1: evaluation of peptide efficiency in vitro and in an in vivo model of AD". Trabalho apresentado em XIV Meeting of the Portuguese Society of Neuroscience, Póvoa de Varzim, Portugal, 2015.
  29. Carmo-Silva, Sara; Nóbrega, Clévio; Botelho, Mariana; Ferreira-Marques, Marisa; Aveleira, Célia; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Hypothalamic ataxin-2 regulates energy balance and metabolism". Trabalho apresentado em Keystone Symposia, Neural Control of Metabolic Physiology and Diseases, Snowbird, Utah, USA, 2015.
  30. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda. "Tackling Alzheimer’s disease with a new inhibitor of BACE1: evaluation of compound efficacy in vitro and in a cellular model of Alzheimer’s disease". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal, 2014.
  31. Aveleira, Célia; Botelho, Mariana; Carmo-Silva, Sara; Sousa-Ferreira, Lígia; Ferreira-Marques, Marisa; Nóbrega, Clévio; López-Otín, Carlos; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y rescues the phenotype of a mousse model of human premature aging". Trabalho apresentado em XII CNC Annual Meeting, University of Coimbra, Coimbra, Portugal, 2014.
  32. Aveleira, Célia; Botelho, Mariana; Carmo-Silva, Sara; Sousa-Ferreira, Lígia; Ferreira-Marques, Marisa; Nóbrega, Clévio; López-Otín, Carlos; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y ameliorates the phenotype of a mousse model of human premature aging". Trabalho apresentado em 7th Progeria Research Foundation International Workshop – Hand in Hand: Basic and Clinical Science Working Together Toward the Cure, Bethesda, MD, USA, 2013.
Tese / Dissertação
  1. Ferreira-Marques, Marisa. "Autophagy in cortical neurons : role of caloric restriction and neuropeptide Y". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2013. https://ap1-dev.uc.pt/handle/10316/24620.

Propriedade Intelectual

Patente
  1. Santos, Armanda; Resende, Rosa; Pereira, Cláudia; Ferreira-Marques, Marisa; Dinis, Teresa. 2017. "Peptide inhibitors of BACE1 for the treatment of neurological disorders". Portugal.
    Concedida/Emitida
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/02 Ataxin-2 prevents the circadian rhythm deregulation induced by saturated fatty acids L Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2020/02 Targeting the neuroendocrine system to slow down skin aging L Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2020/02 Development of in vitro approaches to evaluate hypothalamic insulin signaling in metabolic dysfunctions L Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2019/06 Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2 Gordon Research Seminar on Clocks in Model Organisms: Circadian Networks, Physiology and Heath
(Castelldefels, Espanha)
2019/04 Autophagy and Aging Mechanobiology of Migrating Cells: From Basic Science to the Clinic, A COST Action CA15214 (EuroCellNet)
(Coimbra, Portugal)
2019/04 Hypothalamic ataxin-2: Resetting the clock on obesity 26th European Congress on Obesity
(Glasglow, Reino Unido)
2019/03 New chimeric peptides selectively inhibit APPß cleavage decreasing Aß formation and accumulation in AD models 14th International Conference on Alzheimer’s & Parkinson’s Diseases
(Lisboa, Portugal)
2019/02 A neuroendocrine strategy to delay aging of Hutchinson-Gilford Progeria Syndrome XLIX Meeting of the Portuguese Society of Pharmacology
(Porto, Portugal)
2018/11 Hypothalamic ataxin-2: a modulator of circadian rhythm and metabolism 22.º Congresso Português de Obesidade - Obesidade: Um peso a reduzir
(Lisboa, Portugal)
2018/11 Hypothalamic ataxin-2 at the crossroads of metabolism and circadian rhythm Chrononutrition: From Epidemiology to Molecular Mechanism Symposium
(London, Reino Unido)
2018/10 New chimeric peptides selectively inhibit APP-ß cleavage 32ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência
(Lisboa, Portugal)
2018/07 Neuropeptide y rescues aging phenotype of human Hutchinson-Gilford Progeria Syndrome fibroblasts 18th World Congress of Basic and Clinical Pharmacology
(Kyoto, Japão)
2018/02 Caloric restriction activates autophagy in mouse cerebral cortex XLVIII Meeting of the Portuguese Society of Pharmacology
(Lisboa, Portugal)
2018/02 Ghrelin administration as a novel strategy to delay aging in Hutchinson-Gilford Progeria Syndrome XLVIII Meeting of the Portuguese Society of Pharmacology
(Lisboa, Portugal)
2018/02 Hypothalamic ataxin-2 regulates circadian rhythm in mice XLVIII Meeting of the Portuguese Society of Pharmacology
(Lisboa, Portugal)
2017/02 Caloric restriction stimulates autophagy in rat cortical neurons through ghrelin receptor activation XLVII Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2017/02 Hypothalamic ataxin-2 modulates body weight and insulin sensitivity XLVII Meeting of the Portuguese Society for Pharmacology
(Coimbra, Portugal)
2017/02 Ghrelin ameliorates the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells XLVII Meeting of the Portuguese Society for Pharmacology
(Coimbra, Portugal)
2017/02 New peptide inhibitors of bace1: towards Alzheimer's disease treatment XLVII Meeting of the Portuguese Society for Pharmacology
(Coimbra, Portugal)
2017/02 Autophagy is stimulated by NPY Y1 and Y5 receptors activation in hypothalamic neurons XLVII Meeting of the Portuguese Society for Pharmacology
(Coimbra, Portugal)
2016/06 New BACE1 inhibitors decrease Aß production in cellular and in vivo models of Alzheimer's disease 30ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência
(Lisboa, Portugal)
2016/02 Hypothalamic ataxin-2 contributes to energy balance regulation and metabolism XLVI Meeting of the Portuguese Society for Pharmacology
(Porto, Portugal)
2016/02 New BACE1 inhibitors for Alzheimer’s disease treatment: evaluation of their efficacy in in vitro and in vivo models 15th Iberian Peptide Meeting, Porto, Portugal
(Porto, Portugal)
2015/08 Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons 11th NPY-PYY-PP International Meeting
(Leipzig, Alemanha)
2015/05 New promising peptides to inhibit BACE1: evaluation of compound efficiency in cellular and mouse models of Alzheimer’s disease 29ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência
(Aveiro, Portugal)
2014/12 Autophagic flux is stimulated by NPY in hypothalamic neurons and is relevant to synaptic plasticity on POMC hypothalamic neurons XII CNC Annual Meeting
(Coimbra, Portugal)
2014/02 Caloric restriction and Neuropeptide Y induces autophagy in cortical neurons XLIV Meeting of the Portuguese Society for Pharmacology
(Coimbra, Portugal)
2014/02 Hypothalamic Neuropeptide Y ameliorates the phenotype of a mouse model of human premature aging XLIV Meeting of the Portuguese Society for Pharmacology
(Coimbra, Portugal)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2020/04/01 - Atual “Clinical Investigator Certificate - Level 1”, course promoted by Training Programme in Pharmaceutical Medicine, UNAVE and by PtCRIN - Portuguese Clinical Research Infrastructures Network, e-learning format.
Outro
Universidade de Aveiro, Portugal

Universidade Nova de Lisboa, Portugal
2020/04 - 2020/04 “O Essencial da Gestão de Dados de Investigação”, course promoted by Fundação para a Computação Científica Nacional (FCCN) @ NAU - Always Learning.
Outro
Fundação para a Ciência e a Tecnologia, Portugal

Fundacao para a Computacao Cientifica Nacional, Portugal
2020/04 - 2020/04 “Higiene das Mãos na Prevenção de Infeções”; course promoted by Fundação para a Computação Científica Nacional (FCCN) @ NAU - Always Learning.
Outro
Fundação para a Ciência e a Tecnologia, Portugal

Fundacao para a Computacao Cientifica Nacional, Portugal
2020/04 - 2020/04 “Uso Seguro e Responsável do Medicamento”; course promoted by Fundação para a Computação Científica Nacional (FCCN) @ NAU - Always Learning.
Outro
Fundação para a Ciência e a Tecnologia, Portugal

Fundacao para a Computacao Cientifica Nacional, Portugal
2020/04 - 2020/04 “Prevenção de Infeções e Resistência aos Antibióticos”; course promoted by Fundação para a Computação Científica Nacional (FCCN) @ NAU - Always Learning.
Outro
Fundação para a Ciência e a Tecnologia, Portugal

Fundacao para a Computacao Cientifica Nacional, Portugal
2019/12/19 - 2019/12/20 Poster presentation at the Centre of Innovative Biomedicine and Biotechnology (CIBB) Annual Meeting 2019, University of Coimbra, Coimbra, Portugal.
Congresso
Centre of Innovative Biomedicine and Biotechnology (CIBB) Annual Meeting 2019
Centro de Inovação em Biotecnologia e Biomedicina, Portugal
2019/10/09 - 2019/10/12 Poster presentation at the 3rd Molecular Biology of Ageing Meeting, Groningen, The Netherlands.
Congresso
3rd Molecular Biology of Ageing Meeting
European Research Institute for the Biology of Ageing, Países Baixos
2019/10/04 - 2019/10/04 “How to Write a Great Research Paper, and Get it Accepted by a Good Journal”, workshop promoted by ELSEVIER, Anthony Newman and Sarah Rodrigues.
Oficina (workshop)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/06/28 - 2019/06/29 Poster presented at the Ageing: Models, Mechanisms and Therapies Conference, University of Coimbra, Coimbra, Portugal.
Conferência
Ageing: Models, Mechanisms and Therapies Conference
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/05/10 - 2019/05/10 Poster presentation at the 1st Neuroscience and Disease Retreat of the Center of Innovative Biomedicine (CIBB) and Biotechnology, University of Coimbra, Coimbra, Portugal.
Congresso
1st Neuroscience and Disease Retreat of the Center of Innovative Biomedicine and Biotechnology (CIBB)
Centro de Inovação em Biotecnologia e Biomedicina, Portugal
2019/02/06 - 2019/02/09 Oral presentation at the XLIX Meeting of the Portuguese Society of Pharmacology, Porto, Portugal.
Congresso
XLIX Meeting of the Portuguese Society of Pharmacology
Sociedade Portuguesa de Farmacologia, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2018/09/05 - 2018/09/14 “From molecules to tissues”, summer school in Computational Biology.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/04/10 - 2018/05/16 Entrepreneurship on “IneoStart'18 - Team StepAging” program for accelerating business and innovation ideas with 80 hours of training. Sessions: Business Model Canvas and How to Pitch; Customer Development and Lean Prototyping; Marketing to startups; Startups and investment; Final Pitch; “Demo Day”.
Oficina (workshop)
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2018/05/05 - 2018/05/06 Hands-on activities at the “ Hackathon: Hack For Good”.
Oficina (workshop)
Fundação Calouste Gulbenkian, Portugal
2018/03/28 - 2018/03/28 Hands-on activities at the “Escola Ciência Viva | Novembro 2018 – Junho 2019”.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/03/12 - 2018/03/18 “Advanced Course in Ageing: from cellular processes to the organism”, course of the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB).
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/02/05 - 2018/02/07 Oral presentation at the XLVIII Meeting of the Portuguese Society of Pharmacology, Lisbon, Portugal.
Congresso
XLVIII Meeting of the Portuguese Society of Pharmacology
Sociedade Portuguesa de Farmacologia, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2017/09/30 - 2017/10/01 Hands-on activities at the “Hackthlon: Hack 4 Ageing Well”, of the Active and Assisted Living Programme.
Oficina (workshop)
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2017/05/15 - 2017/05/26 “Advanced Course in Principles and Practice in Drug Development”, course of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB).
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/05/04 - 2017/05/06 Hands-on activities at the “i9agri - First Innovation Agrifood Fair in Portugal”.
Exposição
Centro de Exposições e Eventos da Associação Empresarial da Beira Baixa, Portugal
2017/04/10 - 2017/04/13 “Advanced Course in Science Communication and Soft Skills”, course of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB).
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/03/01 - 2017/03/31 Hands-on activities at the “Brain Awareness Week – Brains in the Laboratories”.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/03/13 - 2017/03/17 “Advanced Course in Cardiovascular Sciences”, optional course offered Faculty of Medicine.
Outro
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/02/02 - 2017/02/04 Oral presentation at the XLVII Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal.
Congresso
XLVII Meeting of the Portuguese Society for Pharmacology
Sociedade Portuguesa de Farmacologia, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2016/11/28 - 2016/11/28 Hands-on activities at the “Science and Technology Week”.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/09/30 - 2016/09/30 Hands-on activities at the “International Researchers’ Night”.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/09/30 - 2016/09/30 Poster presentation at the 1st Symposium on Aging Research @CNC, University of Coimbra, Coimbra, Portugal.
Simpósio
1st Symposium on Aging Research @CNC
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/03/12 - 2016/03/20 Hands-on activities at the “Brain Awareness Week – Neuroscientists go to School”.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/07/16 - 2015/07/16 Hands-On Course on “Biostatistics for research”, workshop of the Laboratory of Biostatistics and Medical Informatics.
Oficina (workshop)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/06/04 - 2015/06/05 Poster presentation at the XIV Meeting of the Portuguese Society of Neuroscience, Póvoa de Varzim, Portugal.
Congresso
XIV Meeting of the Portuguese Society of Neuroscience
Sociedade Portuguesa de Neurociências, Portugal
2015/05/29 - 2015/05/30 Oral presentation at the 29ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência, Aveiro, Portugal. 29ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudo de Envelhecimento Cerebral e Demências, Portugal
2014/12/17 - 2014/12/20 Poster presentation at the XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal.
Congresso
XVIII Congress of the Portuguese Biochemical Society
Sociedade Portuguesa de Bioquímica, Portugal
2014/09/26 - 2014/09/26 Hands-on activities at the “International Researchers’ Night”.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/03/12 - 2014/03/14 Hands-On Course on “Microscopy Imaging Analysis”, course of the Microscopy Imaging Center of Coimbra.
Oficina (workshop)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/02/11 - 2014/02/13 Course on “Laboratory Animal Science - FELASA level B certification”.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/02/05 - 2014/02/07 Oral presentation at the XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal.
Congresso
XLIV Meeting of the Portuguese Society for Pharmacology
Sociedade Portuguesa de Farmacologia, Portugal

Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/09/27 - 2013/09/27 Hands-on activities at the “International Researchers’ Night”.
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018/05/21 - 2018/05/28 Class in a laboratory context of the bachelor’s degree in Biomedical Pharmacy, Pre-Clinical Drug Development, Center for Neuroscience and Cell Biology, Neuroendocrinology and Aging Group, University of Coimbra, Coimbra, Portugal. Farmácia Biomédica (Licenciatura) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/04/07 - 2018/05/24 Co-organizer and lecturer of the Advanced course “Metabolism and Aging: Searching for the elixir of youth” (7 theoretical/practical classes, 2.5 hours each) to undergraduate students, high school students and teachers, under the program “Science in Action”. (Outros) Instituto de Educação e Cidadania, Portugal

Membro de associação

Nome da associação Tipo de participação
2020/01 - Atual Society for Endocrinology Membership

Tutoria

Tópico Nome do aluno
2020/02 - Atual Laboratory Internship Supervision (laboratory support during master thesis development) Ana Cláudia Bessa
2018/09 - Atual Laboratory Internship Supervision (laboratory support during master dissertation development) Inês Oliveira
2019/09/03 - 2019/09/07 Laboratory Supervision “Ciência Viva no Laboratório - Ocupação Científica de Jovens nas Férias 2018”
2019/09/02 - 2019/09/06 Laboratory Supervision “Ciência Viva no Laboratório - Ocupação Científica de Jovens nas Férias 2019”
2018/09 - 2019/08 Laboratory Internship Supervision (laboratory support during master thesis development) Ana Catarina Franco
2018/09 - 2019/08 Laboratory Internship Supervision (laboratory support during master thesis development) Inês Ferreira Dinis
2019/01 - 2019/02 Laboratory Rotation Supervision Rafael Baganha
2018/04 - 2018/07 Laboratory Internship Supervision Ana Catarina do Ó Vinhas
2016/09 - 2017/08 Laboratory Internship Supervision (laboratory support during master thesis development) André Carlos Carvalho
2017/07/24 - 2017/07/28 Laboratory Supervision "Ciência Viva no Laboratório - Ocupação Científica de Jovens nas Férias 2017”
2017/07/03 - 2017/07/14 Laboratory Supervision Anna Klícová
2017/05 - 2017/06 Laboratory Internship Supervision Carolina Eugénia Pinto
2017/02 - 2017/06 Laboratory Internship Supervision Cláudia Rego Rodrigues
2017/04/10 - 2017/04/12 Laboratory Supervision "Estágios Científicos do IEC"
2016/12/21 - 2016/12/23 Laboratory Supervision “Estágios de Natal no CNC”
2016/07/25 - 2016/07/29 Laboratory Supervision “Ciência Viva no Laboratório - Ocupação Científica de Jovens nas Férias 2016”
2016/07/18 - 2016/07/29 Laboratory Supervision May Žitnik
2016/02 - 2016/06 Laboratory Internship Supervision Ana Beatriz Ferreira
2016/04/04 - 2016/04/29 Laboratory Rotation Supervision Carolina dos Santos Vinagreiro
2016/01/11 - 2016/01/31 Laboratory Rotation Supervision Miguel Jorge Lemos
2015/11/16 - 2015/12/18 Laboratory Rotation Supervision Mariana Gomes Manso
2015/11/16 - 2015/11/27 Laboratory Rotation Supervision Ana Rita Mendes, Carla Henriques and Miguel Jorge Lemos
2015/10/19 - 2015/11/06 Laboratory Rotation Supervision Catarina Pechincha
2015/07/22 - 2015/07/26 Laboratory Supervision “Ciência Viva no Laboratório - Ocupação Científica de Jovens nas Férias 2015”
2015/07/08 - 2015/07/21 Laboratory Rotation Supervision Cláudia Soares, Diana Oliveira and João Gonçalves
2015/03/02 - 2015/03/27 Laboratory Rotation Supervision André Sousa
2015/03/02 - 2015/03/27 Laboratory Rotation Supervision Yolanda Sofia Afonso
2013/07/08 - 2013/07/19 Laboratory Supervision “Ciência Viva no Laboratório - Ocupação Científica de Jovens nas Férias 2013”
Distinções

Prémio

2018 2nd Prize "Janssen Innovation Award - Neuroscience 2018"
Janssen-Cilag Farmacêutica Lda, Portugal
2017 2nd Prize “Hackathlon: Hack 4 Ageing Well”
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2016 PhD Fellowship (SFRH/BD/120023/2016)
Fundação para a Ciência e a Tecnologia, Portugal