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Ana Raquel Sarabando Santiago (Ana Raquel Santiago, ARS) is Assistant Professor (area of Immunology) at the Faculty of Medicine of the University of Coimbra (FMUC) and she a researcher at the Coimbra Institute for Clinical and Biomedical Research (iCBR) of FMUC. She is a member of the Board of the Portuguese Glial Network. She is the Coordinator of the Animal Facility in FMUC and the President of the Institutional Animal Care and Use Committee of iCBR-FMUC. She is also a collaborator at the Association for Innovation and Biomedical Research on Light (AIBILI) at the Centre of New Technologies for Medicine, a unit developing diagnostic tools for eye fundus imaging. ARS is a Biochemist with a PhD in Cell Biology (2008), with part of the experimental work performed at Penn State College of Medicine (USA) and Institute for Neurosciences and Amsterdam Medical Center (The Netherlands). During her PhD, ARS studied the mechanisms by which glutamate excitotoxicity contributes to retinal neurodegeneration in the early stages of diabetic retinopathy, the leading complication of diabetes. As a post-doctoral FCT fellow, she joined iCBR and started a new line of research on the study of neuroinflammation and neuroprotection in glaucoma, a leading cause of vision worldwide. As a post-doc, she also worked at the laboratories of Elena Vecino (Basque Country University, Spain) and David Calkins (Vanderbilt Eye Institute, USA). Currently, ARS has been interested in the contribution of glial cells and neuroinflammation to retinal neurodegeneration, and the identification of therapeutic strategies for retinal diseases targeting neuroprotection and neuroinflammation control. She published 51 articles in peer-reviewed journals, with an h-index of 24 and 1314 citations (as of February 22, 2022). ARS has participated in important and renowned national and international scientific meetings in the field of eye and vision research and neuroinflammation (17 oral communications by invitation). The work developed or coordinated by ARS has been presented in more than 170 poster presentations in scientific meetings. Raquel Santiago has attracted competitive funding from national and international agencies in highly competitive calls (7 projects as Principal Investigator, 17 as team member, and 2 projects as research fellow). She has organized several scientific meetings, including symposia in international meetings. She supervised 5 PhD students, 13 Msc students, 2 post-docs, and project fellows. She has been in the jury of Msc and PhD thesis, including as main opponent, and she has been actively collaborating with Doctoral and Master courses of FMUC. She is member of the editorial board of Cell Biology, Journal of Ophthalmology and Scientific Reports. She is Associate Editor in Frontiers in Pharmacology, Frontiers in Neuroscience and Frontiers in Cellular Neuroscience and she is/was guest editor of several special issues related with the contribution of microglia to neurodegeneration and with therapeutic strategies for retinal diseases. She has been acting as reviewer in several scientific journals and as project evaluator for the German Research Foundation, Dutch Research Council, UK Medical Research Council, among other funding agencies. ARS is a COST Expert and was member of the COST Action entitled Development of A European Network for Preclinical Testing of Interventions in Mouse Models of Age and Age-Related Diseases (MouseAGE, BM1402) and is currently member of the COST Action CA20121 entitled Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases (BenBedPhar). In addition to her scientific activity, ARS has also participated in several science communication activities including the World Sight Day, Brain Awareness week, European Researchers Night, as well as in other activities related with science dissemination to high school students. She is part of the Outreach Committee of the Portuguese Glial Network.
Identificação

Identificação pessoal

Nome completo
Ana Raquel Sarabando Santiago

Nomes de citação

  • Santiago, Ana
  • Santiago, AR
  • Santiago, Ana Raquel

Identificadores de autor

Ciência ID
E910-E39E-0974
ORCID iD
0000-0002-7541-7041
Researcher Id
I-6566-2013
Scopus Author Id
55481378200

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Formação
Grau Classificação
2008/09/01 - 2009/06/30
Concluído
Adenosine as a neuromodulator of retinal ganglion cells physiology: implication for neuroprotection (Pós-doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2008/06/30
Concluído
Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mechanisms of neurodegeneration in the early stages of diabetic retinopathy: the involvement of glutamate" (TESE/DISSERTAÇÃO)
Approved with distinction and honor by unanimity
2002
Concluído
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mechanisms of vascular and neuronal cell degeneration in the early stages of Diabetic Retinopathy" (TESE/DISSERTAÇÃO)
16/20 (Good)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2018/12/22 - 2020/08/31 Investigador Contratado (Investigação) Universidade de Coimbra, Portugal
2017/07/15 - 2018/12/20 Pós-doutorado (Investigação) Universidade de Coimbra, Portugal
CNC.IBILI, Portugal
2015/07/15 - 2017/07/14 Pós-doutorado (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
(...)
2014/07/15 - 2015/07/14 Gestão de Ciência e Tecnologia Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2009/07/01 - 2014/06/30 Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2008/09/01 - 2009/06/30 Pós-doutorado (Investigação) Universidade de Coimbra, Portugal
Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Portugal
2008/03/01 - 2008/09/30 Investigador (Investigação) Universidade de Coimbra, Portugal
Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2020/09/01 - Atual Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2007/09/01 - 2008/07/30 Professor Auxiliar (Docente Universitário) Universidade Internacional da Figueira da Foz, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2019/10/14 - Atual Coordinator of the Animal Facility Universidade de Coimbra Faculdade de Medicina, Portugal
Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2019/10/14 - Atual President of the Institutional Animal Care and Use Committee Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/05/23 - 2011/06/06 Experience in foreign labs in Laboratory of Dr. David Calkins Vanderbilt University Medical Center, Estados Unidos
2009/06/01 - 2009/06/30 Experience in foreign labs in Laboratory of Prof. Elena Vecino Cordero Universidad del País Vasco, Espanha
Universidad del País Vasco Departamento de Biología Celular e Histología, Espanha
2006/01/01 - 2006/06/30 Experience in foreign labs in Laboratory of Prof. Dr. Reinier Schlingemann Institute for Neurosciences and Amsterdam Medical Center, Países Baixos
2005/01/01 - 2005/04/30 Experience in foreign labs in Laboratory of Dr. Willem Kamphuis Netherlands Research Ophthalmic Institute, Países Baixos
2004/03/01 - 2004/09/02 Experience in foreign labs in Laboratory of Dr. Alistair Barber Penn State College of Medicine, Estados Unidos
Penn State Retina Research Group, Estados Unidos
2003/09/15 - 2003/09/22 Experience in foreign labs in Laboratory of Prof. Alvaro Rendon Sorbonne Université Campus Pierre et Marie Curie, França
Laboratoire de Physiopathologie Cellulaire et Moléculaire de la Rétine, França
Projetos

Bolsa

Designação Financiadores
2013 - 2013/10 Adenosine A3 receptor: a new therapeutic target for the treatment of glaucoma?
Santiago06.01.13
Investigador responsável
GAI - Faculty of Medicine, Unviversity of Coimbra
2008 - 2009/06 Pos-Doc Fellowship
SFRH/BPD/34660/2007
Fundação para a Ciência e a Tecnologia
2002 - 2006/09 PhD Fellowship
SFRH/BD/9690/2002
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2018 - Atual ExoSwitch - Understanding the switch between dry and wet AMD: role of exosomes
Investigador
Global Ophthalmology Awards Program - Bayer HealthCare, Alemanha
Global Ophthalmology Awards Program - Bayer HealthCare
Em curso
2016 - 2019/12/31 Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma
PTDC/NEU-OSD/3123/2014
Investigador responsável
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016 - 2019/12 Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma
PTDC/NEU-OSD/3123/2014
Investigador responsável
Fundação para a Ciência e a Tecnologia
2016 - 2018/12 The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression?
MB-1049-2015
Investigador
Santa Casa da Misericórdia de Lisboa, Portugal
Santa Casa da Misericórdia de Lisboa
Concluído
2014 - 2018/11 Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE)
Biomedicine and Molecular Biosciences (BMBS) COST Action BM1402
Investigador
European Commision – Horizon 2020, Bélgica
European Commision – Horizon 2020
Concluído
2015 - 2018/02/28 Managing inflammation in diabetic retinopathy by adenosine A2A receptor blockade
n/a
Investigador responsável
Global Ophthalmology Awards Program - Bayer HealthCare, Alemanha
Global Ophthalmology Awards Program - Bayer HealthCare
Concluído
2016 - 2017/07/31 Exosomes as amplifiers of inflammation: microglia-Müller cell communication in glaucoma
GAI-Santander Totta 2016_224
Investigador responsável
Faculty of Medicine, University of Coimbra, Portugal
Faculty of Medicine, University of Coimbra
Concluído
2014 - 2015/12/31 The potential protective effect of caffeine in the retina: relevance for the treatment of glaucoma
n/a
Investigador responsável
Manuel Rui Azinhais Nabeiro, Lda, Portugal
Manuel Rui Azinhais Nabeiro, Lda
Concluído
2015 - 2015/10/31 Biodegradable intravitreal porous implants for extended release of A3 adenosine receptor agonist for the protection of retinal ganglion cells - a potential therapeutic strategy for the treatment of glaucoma
ASantiago.GAI2015
Investigador responsável
Faculty of Medicine, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina
Concluído
2013 - 2015/09 From neuroinflammation control to neuroprotection: blocking adenosine A2A receptor for the treatment of glaucoma
PTDC/BIM-MEC/0913/2012
Investigador responsável
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2015/04 Neuropeptide Y system: a new potential therapeutic target in diabetic retinopathy
PTDC/NEU-OSD/1113/2012
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012 - 2014/10 Inhibitors of FAAH (fatty acid amide hydrolase): evaluation of their potential to reduce intraocular pressure and neuroprotective effect in the retina
CNTM/344
Investigador
BIAL Farmacêutica, Portugal
BIAL Farmacêutica
Concluído
2013 - 2013/10/31 Adenosine A3 receptor: a new therapeutic target for the treatment of glaucoma?
GAI Santiago06.01.13
Investigador responsável
Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina
Concluído
2010 - 2013/03 Life and death of retinal ganglion cells: unmasking the neuromodulatory and neuroprotective roles of Neuropeptide Y
PTDC/SAU-NEU/99075/2008
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2012/12 Regulation of retinal growth factors secretion by Rab GTPases
PTDC/SAU-OSM/104668/2008
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2012/10 Neuropeptide Y system: a new key player and potential therapeutic target in diabetic retinopathy?
FA0911
Investigador
Faculty of Medicine, University of Coimbra, Portugal
Faculty of Medicine, University of Coimbra
Concluído
2011 - 2012 Inhibitors of FAAH (fatty acid amide hydrolase): evaluation of their potential to reduce intraocular pressure
n/a
Investigador
BIAL Farmacêutica, Portugal
BIAL Farmacêutica
Concluído
2010 - 2011/12 Retinal ganglion cell neuroprotection in models of glaucoma: identification of potential therapeutic targets
n/a
Investigador
Foundation for Science and Technology (FCT) – Transnational cooperation FCT/CAPES , Portugal
Foundation for Science and Technology (FCT) – Transnational cooperation FCT/CAPES
Concluído
2007 - 2010/12 Regulation of AMPA receptors by hyperglycemia in the retina
PTDC/SAU-NEU/71228/2006
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2008/09 Nanomedicine and new therapeutic strategies – development of supramolecular structures for the treatment of ophthalmologic diseases
n/a
Bolseiro de Investigação
Comissão de Coordenação e Desenvolvimento Regional do Centro, Portugal

Faculty of Medicine, University of Coimbra, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro

Faculty of Medicine, University of Coimbra
Concluído
2006 - 2007/04 ATP and diabetic retinophaty: role in the regulation of microglia and in neuronal death
POCTI/SAU-NEU/59003/2004
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2006 - 2006/12 Tauroursodeoxycholic acid: a novel neuroprotective drug in diabetic retinopathy?
GAI 07/06
Investigador
Faculty of Medicine, University of Coimbra, Portugal
GAI - Faculty of Medicine, Unviversity of Coimbra
Concluído
2006 - 2006/06 Retinal gene expression profiles in an experimental model for diabetic retinopathy
n/a
Investigador
Gelderse Blinden Stichting, Países Baixos

Landelijke Stichting voor Blinden en Slechtzienden, Países Baixos

Rotterdamse Vereniging Blindenbelangen, Países Baixos
Gelderse Blinden Stichting

Landelijke Stichting voor Blinden en Slechtzienden

Rotterdamse Vereniging Blindenbelangen
Concluído
2002 - 2005/12 Mechanisms of cell degeneration in diabetic retinopathy
POCTI/CBO/38545/2001
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2003 - 2003/12 Effects of hyperglycemia in the purine release in the retina
GAI 13/03
Investigador
Faculty of Medicine, University of Coimbra, Portugal
Gabinete Apoio à investigação, (GAI) Faculty of Medicine, University of Coimbra
Concluído
Produções

Publicações

Artigo em conferência
  1. P.A.N. Dias; S. Bizarro; Raquel Boia; Santiago, AR. "Development of Innovative Porous Ocular Implants by a Green Supercritical Foaming/Mixing Technology". Trabalho apresentado em 16th European Meeting on Supercritical Fluids (EMSF), Lisbon, 2017.
    Publicado
  2. Pedro Oliveira, J.; Caixinha, M.; Aires, I.D.; Santiago, A.R.; Santos, M.; Santos, J.. "In vivo detection of cornea structural changes in an animal model of diabetes mellitus". Trabalho apresentado em 5th Portuguese Meeting in Bioengineering IEEE-EMBS (ENBENG’2017), Coimbra, 2017.
    10.1109/ENBENG.2017.7889445
Artigo em revista
  1. Boia, Raquel; Dias, Paulo A.N.; Galindo-Romero, Caridad; Ferreira, Hugo; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al. "Intraocular implants loaded with A3R agonist rescue retinal ganglion cells from ischemic damage". Journal of Controlled Release 343 (2022): 469-481. http://dx.doi.org/10.1016/j.jconrel.2022.02.001.
    10.1016/j.jconrel.2022.02.001
  2. Inês Dinis Aires; Teresa Ribeiro-Rodrigues; Raquel Boia; Magda Ferreira-Rodrigues; Henrique Girão; António Francisco Ambrósio; Ana Raquel Santiago. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading". Biomolecules (2021): https://doi.org/10.3390/biom11060770.
    10.3390/biom11060770
  3. Inês Dinis Aires; Teresa Ribeiro-Rodrigues; Raquel Boia; Steve Catarino; Henrique Girão; António Francisco Ambrósio; Ana Raquel Santiago. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells". Glia (2020): https://doi.org/10.1002/glia.23880.
    10.1002/glia.23880
  4. Joana Ferreira-Silva; Inês D. Aires; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago. "Activation of Adenosine A3 Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21197218.
    10.3390/ijms21197218
  5. C. Henrique Alves; Rosa Fernandes; Ana Raquel Santiago; António Francisco Ambrósio. "Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration". Cells (2020): https://doi.org/10.3390/cells9051217.
    10.3390/cells9051217
  6. Raquel Boia; Manuel Salinas-Navarro; Alejandro Gallego-Ortega; Caridad Galindo-Romero; Inês D. Aires; Marta Agudo-Barriuso; António Francisco Ambrósio; Manuel Vidal-Sanz; Ana Raquel Santiago. "Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension". Cell Death & Disease 11 5 (2020): https://doi.org/10.1038/s41419-020-2593-y.
    10.1038/s41419-020-2593-y
  7. Boia, Raquel; Ruzafa, Noelia; Aires, Inês Dinis; Pereiro, Xandra; Ambrósio, António Francisco; Vecino, Elena; Santiago, Ana Raquel. "Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead". International Journal of Molecular Sciences 21 7 (2020): 2262. http://dx.doi.org/10.3390/ijms21072262.
    10.3390/ijms21072262
  8. Santiago, Ana Raquel; Madeira, Maria H.; Boia, Raquel; Aires, Inês Dinis; Rodrigues-Neves, Ana Catarina; Santos, Paulo Fernando; Ambrósio, António Francisco. "Keep an eye on adenosine: Its role in retinal inflammation". Pharmacology & Therapeutics (2020): 107513. http://dx.doi.org/10.1016/j.pharmthera.2020.107513.
    10.1016/j.pharmthera.2020.107513
  9. Inês Dinis Aires; Maria Helena Madeira; Raquel Boia; Ana Catarina Rodrigues-Neves; Joana Margarida Martins; António Francisco Ambrósio; Ana Raquel Santiago. "Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-53627-y.
    10.1038/s41598-019-53627-y
  10. Boia, Raquel; Dias, Paulo A.N.; Martins, Joana M.; Galindo-Romero, Caridad; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al. "Porous poly(e-caprolactone) implants: A novel strategy for efficient intraocular drug delivery". Journal of Controlled Release 316 (2019): 331-348. http://dx.doi.org/10.1016/j.jconrel.2019.09.023.
    10.1016/j.jconrel.2019.09.023
  11. Caixinha, Miguel; Oliveira, Pedro; Aires, Inês D.; Ambrósio, António Francisco; Santiago, Ana Raquel; Santos, Mário; Santos, Jaime. "In Vivo Characterization of Corneal Changes in a Type 1 Diabetic Animal Model". Ultrasound in Medicine & Biology 45 3 (2019): 823-832. http://dx.doi.org/10.1016/j.ultrasmedbio.2018.11.002.
    10.1016/j.ultrasmedbio.2018.11.002
  12. Inês Dinis Aires; Raquel Boia; Ana Catarina Rodrigues-Neves; Maria Helena Madeira; Carla Marques; António Francisco Ambrósio; Ana Raquel Santiago. "Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells". Glia (2019): https://doi.org/10.1002/glia.23579.
    10.1002/glia.23579
  13. M. H. Madeira; K. Rashid; A. F. Ambrósio; A. R. Santiago; T. Langmann. "Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-20733-2.
    10.1038/s41598-018-20733-2
  14. Santiago, Ana R.; Boia, Raquel; Aires, Inês D.; Ambrósio, António F.; Fernandes, Rosa. "Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.00820.
    10.3389/fphys.2018.00820
  15. Mariana R. P. Alves; Raquel Boia; ELISA J CAMPOS; João Martins; Sara Nunes; Maria H. Madeira; Santiago, AR; et al. "Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes". Molecular Vision (2018):
    Publicado
  16. Campos, Elisa J; Martins, João; Brudzewsky, Dan; Correia, Sandra; Santiago, Ana R; Woldbye, David PD; Ambrósio, António F. "Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina". Clinical & Experimental Ophthalmology 46 7 (2018): 783-795. http://dx.doi.org/10.1111/ceo.13176.
    10.1111/ceo.13176
  17. Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha, Rodrigo A.; et al. "Elevated Pressure Changes the Purinergic System of Microglial Cells". Frontiers in Pharmacology 9 (2018): http://dx.doi.org/10.3389/fphar.2018.00016.
    10.3389/fphar.2018.00016
  18. Boia, Raquel; Elvas, Filipe; Madeira, Maria H; Aires, Inês D; Rodrigues-Neves, Ana C; Tralhão, Pedro; Szabó, Eszter C; et al. "Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage". Cell Death & Disease 8 10 (2017): e3065-e3065. http://dx.doi.org/10.1038/cddis.2017.451.
    10.1038/cddis.2017.451
  19. Inês Dinis Aires; António Francisco Ambrósio; Ana Raquel Santiago. "Modeling Human Glaucoma: Lessons from the in vitro Models". Ophthalmic Research 57 2 (2017): 77-86. https://doi.org/10.1159/000448480.
    10.1159/000448480
  20. Paula Voabil; Joana Liberal; Ermelindo C. Leal; Jacques Bauer; José Cunha-Vaz; Ana Raquel Santiago; António Francisco Ambrósio. "Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model". Ophthalmic Research 58 3 (2017): 150-161. https://doi.org/10.1159/000478784.
    10.1159/000478784
  21. Camila C. Portugal; Renato Socodato; Teresa Canedo; Cátia M. Silva; Tânia Martins; Vivian S. M. Coreixas; Erick C. Loiola; et al. "Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype". Science Signaling 10 472 (2017): eaal2005-eaal2005. https://doi.org/10.1126/scisignal.aal2005.
    10.1126/scisignal.aal2005
  22. Ana Raquel Santiago; Liliana Bernardino; Marta Agudo-Barriuso; Joana Gonçalves. "Microglia in Health and Disease: A Double-Edged Sword". Mediators of Inflammation (2017):
    10.1155/2017/7034143
  23. Maria H. Madeira; Raquel Boia; António F. Ambrósio; Ana R. Santiago. "Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases". Mediators of Inflammation (2017):
    10.1155/2017/4761081
  24. Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago. "Therapeutic Opportunities for Caffeine and A2A Receptor Antagonists in Retinal Diseases". Ophthalmic Research 55 4 (2016): 212-218. https://doi.org/10.1159/000443893.
    10.1159/000443893
  25. Maria H. Madeira; Raquel Boia; Filipe Elvas; Tiago Martins; Rodrigo A. Cunha; António Francisco Ambrósio; Ana Raquel Santiago. "Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury". Translational Research 169 (2016): 112-128. http://dx.doi.org/10.1016/j.trsl.2015.11.005.
    10.1016/j.trsl.2015.11.005
  26. Vindeirinho, J.; Santiago, A.R.; Cavadas, C.; Ambrósio, A.F.; Santos, P.F.. "The adenosinergic system in diabetic retinopathy". Journal of Diabetes Research 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84962289445&partnerID=MN8TOARS.
    10.1155/2016/4270301
  27. Madeira, M.H.; Ortin-Martinez, A.; Nadal-Nícolas, F.; Ambrósio, A.F.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santiago, A.R.. "Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84976443381&partnerID=MN8TOARS.
    10.1038/srep27532
  28. Joana Galvao; Filipe Elvas; Tiago Martins; M. Francesca Cordeiro; António Francisco Ambrósio; Ana Raquel Santiago. "Adenosine A 3 receptor activation is neuroprotective against retinal neurodegeneration". Experimental Eye Research 140 (2015): 65-74. https://doi.org/10.1016/j.exer.2015.08.009.
    10.1016/j.exer.2015.08.009
  29. Santiago, Ana. "Operational Definition of Active and Healthy Aging (AHA): The European Innovation Partnership (EIP) on AHA Reference Site Questionnaire: Montpellier October 20-21, 2014, Lisbon July 2, 2015". Journal of the American Medical Directors Association (2015): http://www.sciencedirect.com/science/article/pii/S1525861015005940.
    doi:10.1016/j.jamda.2015.09.004
  30. Maria Helena Madeira; António Francisco Ambrósio; Ana Raquel Santiago. "Glia-Mediated Retinal Neuroinflammation as a Biomarker in Alzheimer's Disease". Ophthalmic Research 54 4 (2015): 204-211. https://doi.org/10.1159/000440887.
    10.1159/000440887
  31. Socodato, R.; Portugal, C.C.; Domith, I.; Oliveira, N.A.; Coreixas, V.S.M.; Loiola, E.C.; Martins, T.; et al. "c-Src function is necessary and sufficient for triggering microglial cell activation". GLIA 63 3 (2015): 497-511. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920940260&partnerID=MN8TOARS.
    10.1002/glia.22767
  32. Madeira MH; Elvas F; Boia R; Gonçalves FQ; Cunha RA; Ambrósio AF; Santiago AR. "Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.". (2015): http://europepmc.org/abstract/med/26054642.
    10.1186/s12974-015-0333-5
  33. Martins J; Elvas F; Brudzewsky D; Martins T; Kolomiets B; Tralhão P; Gøtzsche CR; et al. "Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.". ASN Neuro 7 4 (2015): 175909141559829. http://europepmc.org/abstract/med/26311075.
    10.1177/1759091415598292
  34. Nadal-Nicolás, F.M.; Madeira, M.H.; Salinas-Navarro, M.; Jiménez-López, M.; Galindo-Romero, C.; Ortín-Martínez, A.; Santiago, A.R.; Vidal-Sanz, M.; Agudo-Barriuso, M.. "Transient downregulation of melanopsin expression after retrograde tracing or optic nerve injury in adult rats". Investigative Ophthalmology and Visual Science 56 8 (2015): 4309-4323. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939856642&partnerID=MN8TOARS.
    10.1167/iovs.15-16963
  35. Madeira MH; Boia R; Santos PF; Ambrósio AF; Santiago AR. "Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases.". (2015): http://europepmc.org/abstract/med/25873768.
    10.1155/2015/673090
  36. Santiago AR; Baptista FI; Santos PF; Cristóvão G; Ambrósio AF; Cunha RA; Gomes CA. "Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.". (2014): http://europepmc.org/abstract/med/25132733.
    10.1155/2014/465694
  37. Santiago, AR; Rodrigues-Sousa, T.; Ladeirinha, A.F.; Santiago, A.R.; Carvalheiro, H.; Raposo, B.; Alarcão, A.; et al. "Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice". PlosOne 9 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84902205044&partnerID=MN8TOARS.
    10.1371/journal.pone.0097532.
  38. Gaspar, JM; Martins, A; Cruz; R; Rodrigues, CMP; Ambrósio, AF; Santiago, AR.. "Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. ". Neuroscience 253 (2013): 9-9.
    10.1016/j.neuroscience.2013.08.053
  39. Ambrosio, Antonio F.; Domingues, Ana F.; Paes-de-Carvalho, Roberto; Portugal, Camila C.; Relvas, Joao B.; Santiago, Ana R.; Santiago, Felipe N.; Socodato, Renato. "Calcium-permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors Trigger Neuronal Nitric-oxide Synthase Activation to Promote Nerve Cell Death in an Src Kinase-dependent Fashion". Journal of Biological Chemistry 287 46 (2012): 38680-38694.
    10.1074/jbc.M112.353961
  40. Ambrosio, Antonio F.; Batista, Ana; Carvalho, Felix; Castelo-Branco, Miguel; Cavadas, Claudia; Fernandes, Eduarda; Galvao, Joana; et al. "Effects of 3,4-Methylenedioxymethamphetamine Administration on Retinal Physiology in the Rat". Plos One 6 12 (2011):
    10.1371/journal.pone.0029583
  41. Ambrosio, A. F.; Carvalho, R. A.; Cristovao, A. J.; Duarte, J. M. N.; Garrido, M. J.; Santiago, A. R.. "Evaluation of the Impact of Diabetes on Retinal Metabolites by NMR Spectroscopy". Current Eye Research 35 11 (2010): 992-1001.
    10.3109/02713683.2010.500113
  42. Ambrosio, Antonio Francisco; Ferreira da Costa, Gabriel Nascimento; Martins dos Santos, Paulo Fernando; Sarabando Santiago, Ana Raquel; Simoes Pereira, Tiago de Oliveira. "High glucose enhances intracellular Ca2+ responses triggered by purinergic stimulation in retinal neurons and microglia". Brain Research 1316 (2010): 129-138.
    10.1016/j.brainres.2009.12.034
  43. Santiago, A.R.; Gaspar, J.M.; Baptista, F.I.; Cristóvão, A.J.; Santos, P.F.; Kamphuis, W.; Ambrósio, A.F.. "Diabetes changes the levels of ionotropic glutamate receptors in the rat retina". Molecular Vision 15 (2009): 1620-1630. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949158370&partnerID=MN8TOARS.
  44. Ambrosio, Antonio F.; Carvalho, Arselio P.; Carvalho, Caetana M.; Santiago, Ana R.. "Differential contribution of L-, N-, and P/Q-type calcium channels to [Ca(2+)](i) changes evoked by kainate in hippocampal neurons". Neurochemical Research 33 8 (2008): 1501-1508.
    10.1007/s11064-008-9618-8
  45. Ambrosio, Antonio F.; Hughes, John M.; Kamphuis, Willem; Santiago, Ana R.; Schlingemann, Reinier O.. "Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina". Brain Research 1198 (2008): 153-159.
    10.1016/j.brainres.2007.12.030
  46. Ambrosio, A. F.; Carvalho, C. M.; Cristovao, A. J.; Santiago, A. R.; Santos, P. F.. "High glucose induces caspase-independent cell death in retinal neural cells". Neurobiology of Disease 25 3 (2007): 464-472.
    10.1016/j.nbd.2006.10.023
  47. Alvaro, Ana Rita; Ambrosio, Antonio Francisco; Aveleira, Celia; Carvalho, Ana Luisa; Cavadas, Claudia; Gouveia, Denisa; Grouzmann, Eric; et al. "NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Muller cells". Neurochemistry International 50 5 (2007): 757-763.
    10.1016/j.neuint.2007.01.010
  48. Ambrosio, Antonio F.; Barber, Alistair J.; Cristovao, Armando J.; Rosa, Susana C.; Santiago, Ana R.; Santos, Paulo F.. "Elevated glucose changes the expression of ionotropic glutamate receptor Subunits and impairs calcium homeostasis in retinal neural cells". Investigative Ophthalmology & Visual Science 47 9 (2006): 4130-4137.
    10.1167/iovs.06-0085
  49. Ambrosio, AF; Cristovao, AJ; Garrido, MJ; Pereira, TS; Santiago, AR; Santos, PF. "High glucose and diabetes increase the release of [H-3]-D-aspartate in retinal cell cultures and in rat retinas". Neurochemistry International 48 6-7 (2006): 453-458.
    10.1016/j.neuint.2005.10.013
  50. Ambrosio, A F; Leal, E C; Santiago, A R. "Old and new drug targets in diabetic retinopathy: from biochemical changes to inflammation and neurodegeneration.". Current drug targets. CNS and neurological disorders 4 4 (2005): 421-34.
    10.2174/1568007054546162
Artigo em revista (magazine)
  1. Santiago, AR. "J. Martins, M. Castelo-Branco, A. Batista, B. Oliveiros, A.R. Santiago, J. Galvão, E. Fernandes, F. Carvalho, C. Cavadas e A.F. Ambrósio. Consumo de ecstasy influencia visão?", ÓpticaPro, section "Interesting Article", 2012
  2. Santiago, AR. "J. Martins, M. Castelo-Branco, A. Batista, B. Oliveiros, A.R. Santiago, J. Galvão, E. Fernandes, F. Carvalho, C. Cavadas e A.F. Ambrósio. Consumo de ecstasy influencia visão?", OftalPro, section "Interesting Article"., 2012
Capítulo de livro
  1. Santiago, AR; M. Castelo-Branco; A.F. Ambrosio. ""Sistema Visual"". In Neurociências, editado por A.C. Rego; C.R. Oliveira; C.B. Duarte, 325-348. Portugal: Lidel, 2017.
    Publicado
Tese / Dissertação
  1. Santiago, AR. "Mechanisms of retinal neurodegeneration in the early stages of diabetic retinopathy: the involvement of glutamate". Doutoramento, Faculty of Sciences and Technology of the University of Coimbra, 2008. http://hdl.handle.net/10316/9632.

Outros

Outra produção
  1. Adenosine A2AR blockade prevents retinal microglial activation. 2012. Ambrosio, A. F.; Elvas, F.; Madeira, M. H.; Martins, J.; Santiago, A. R..
  2. Contribution of Tumor Necrosis Factor Receptor 1 to early cell death in diabetic retinopathy. . 2009. Ambrósio AF; Costa, GN; J. Martins, J; Santiago, AR; Santos, PF.; Silva, S.
    10.3389/conf.neuro.01.2009.11.106
  3. Diabetes decreases glycolysis in the rat retina. 2009. Ambrósio, AF.; Carvalho RA; Cristóvão,AJ; Duarte, JMN; Garrido, MJ; Santiago, AR.
    10.3389/conf.neuro.01.2009.11.085
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/11/30 Invited Speaker - Contribution of microglial exosomes to retinal neuroinflammation V Symposium of the Portuguese Glial Network – Glial cells at the crossroad of health and disease
Portuguese Glial Network (Coimbra, Portugal)
2019/07/10 Exosomes derived from microglia exposed to elevated pressure code for an inflammatory response: implications for retinal degeneration. XIV European Meeting on Glial Cells in Health and Disease
(Porto, Portugal)
2019/05/29 Invited Speaker - Controlling microglia-mediated neuroinflammation in retinal diseases: role of adenosine A2A receptors. IV Symposium of the Portuguese Glial Network - Glia Diversity in Neuromodulation and Neurodegeneration
(Lisbon, Portugal)
2019/05/10 Activation of A3 adenosine receptor using intraocular biodegradable implants as a neuroprotective strategy against glaucomatous degeneration. Retreat of the Centre for Innovative Biomedicine and Biotechnology (CIBB) Neuroscience and Disease research line
(Coimbra, Portugal)
2019/04/27 Extracellular vesicles released by microglia exposed to elevated hydrostatic pressure promote retinal neural cell loss and microglia reactivity. Pan-American Research Day (PARD2019)
(Vancouver, Canadá)
2019/04/27 Adenosine A3 receptor agonist prevents the loss of retinal ganglion cells in a glaucoma model. 2019 Pan-American Research Day (PARD2019)
(Vancouver, Canadá)
2019/04/03 Invited Speaker - Targeting adenosine A2A receptors in retinal microglia: is it a strategy for retinal diseases? Six YES Talk – In the Blink of an Eye
(Porto, Portugal)
2018/10/04 Microglial response to optic nerve injuries. 2018 European Association for Vision and Eye Research Conference
(Nice, França)
2018/09/09 Elevated Hydrostatic Pressure-derived Microglial Extracellular Vesicles Drive Microglia Reactivity: Contribution to Neuroinflammatory Response in Glaucoma Models. XXIII Biennial Meeting of the International Society for Eye Research
(Belfast, Northern Ireland, Reino Unido)
2018/06/21 Invited Speaker - Drug delivery systems as strategies to target the posterior segment of the eye. I Postgraduate Meeting in Ophthalmology and Visual Sciences (University of Coimbra and Federal University of São Paulo)
(Coimbra, Portugal)
2017/09/29 Invited Speaker - Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases. 2017 European Association for Vision and Eye Research Conference
(Nice, França)
2017/04/25 Development of Innovative Porous Ocular Implants by a Green Supercritical Foaming/Mixing Technology. 16th European Meeting on Supercritical Fluids (EMSF)
(Lisbon, Portugal)
2017/02/16 In vivo detection of cornea structural changes in an animal model of diabetes mellitus. 5th IEEE Portuguese BioEngineering Meeting
(Lisbon, Portugal)
2017/02/02 Deepening the characterization of the cuprizone-induced demyelination animal model: moving forward in the search for remyelination in multiple sclerosis. XLVII Annual meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2016/12/19 Invited Speaker - Adenosine A2A receptor inactivation and caffeine abrogate microglia-mediated neuroinflammatin and afford protection to the retina in experimental models of glaucoma. 1st Meeting on Biomedical Research @ UC
(Coimbra, Portugal)
2016/12/01 Intravitreal administration of adenosine A2A receptor antagonist controls microglia-mediated neuroinflammation in a diabetic retinopathy mouse model. The International Symposium on Ocular Pharmacology and Therapeutics (ISOPT) Clinical
(Rome, Itália)
2016/12/01 Treatment with an A2A receptor antagonist reduces neuroinflammation and protects the retina against ischemic damage. The International Symposium on Ocular Pharmacology and Therapeutics (ISOPT)
(Rome, Itália)
2016/11 Caracterização bioquímica do modelo animal de desmielinização induzida pela cuprizona: uma abordagem centrada na dipeptidilpeptidase 4. Congresso de Neurologia 2016
(Lisbon, Portugal)
2016/09/27 Invited Speaker - The blockade of adenosine A2A receptor affords neuroprotection through the control of microglia-mediated neuroinflammation in experimental models of glaucoma. XXII Biennial Meeting of the International Society for Eye Research
(Tokyo, Japão)
2016/09/27 Impact of elevated pressure in the adenosinergic system in microglia and retina. XXII Biennial Meeting of the International Society for Eye Research
(Tokyo, Japão)
2015/12/14 Invited Speaker - Biodegradable intravitreal porous implants for extended release of A3 adenosine receptor agonist for the protection of retinal ganglion cells – a potential therapeutic strategy for the treatment of glaucoma. Dia Da Faculdade De Medicina Universidade De Coimbra
(Coimbra, Portugal)
2015/12/03 Invited Speaker - Managing inflammation in diabetic retinopathy by adenosine A2A receptor blockade. 58º Congresso Português de Oftalmologia
(Vilamoura, Portugal)
2015/12/03 Impact of elevated pressure in the adenosinergic system of microglial cells. 7th Annual Meeting of IBILI
(Coimbra, Portugal)
2015/12/03 Caffeine attenuates neuroinflammatory response and retinal ganglion cell loss in an animal model of glaucoma. 7th Annual Meeting of IBILI
(Coimbra, Portugal)
2015/12/03 Early retinal changes in a rat model of prediabetes: assessment of blood-retinal barrier permeability, structural changes and inflammatory mediators. 7th Annual Meeting of IBILI
(Coimbra, Portugal)
2015/06/04 Caffeine administration modulates neuroinflammation and prevents rat retinal ganglion cell loss induced by ocular hypertension. XIV Meeting of the Portuguese Society for Neurosciences
(Póvoa do Varzim, Portugal)
2015/03/11 Prediabetes does not induce changes in tight junction proteins, neural markers and inflammatory mediators in the rat retina. Leiden International Medical Student Conference (LIMSC)
(Leiden, Países Baixos)
2015/03/06 Invited Speaker - Presentation of the Joint Action on chronic diseases and promoting healthy ageing across the life-cycle (JA-CHRODIS). 3rd regional congress on healthy and active ageing
(Coimbra, Portugal)
2014/12/11 Adenosine A2A receptor blockade and caffeine modulate retinal neuroinflammation. VI Annual Meeting of IBILI
(Coimbra, Portugal)
2014/11/22 Invited Speaker - Targeting adenosine receptors for the treatment of glaucoma: lessons from experimental models. Conferências Abertas de Optometria
(Lisboa, Portugal)
2014/09/04 Sodium vitamin C co-transporter-2 (SVCT-2) regulates the activation of microglial cells. FEBS EMBO 2014 Conference
(Paris, França)
2014/06/19 Invited Speaker - A2AR blockade prevents retinal ganglion cells death through neuroinflammation control. VICT Meeting – Vision and Imaging Consortium for Translational Research
(Coimbra, Portugal)
2014/06/19 Adenosine A2A receptor blockade and caffeine prevent retinal neuroinflammation and retinal ganglion cell death. International Symposium on Ocular Pharmacology and Therapeutics (ISOPT)
(Reykjavik, Islândia)
2014/03/10 Role of neuroinflammation in retinal degenerative diseases: microglia as a potential therapeutic target. I Simpósio da Rede Glial Luso-Brasileira
(Rio de Janeiro, Brasil)
2013/12/12 Invited Speaker - Targeting adenosine receptors in retinal degenerative diseases: from neuroinflammation to neuroprotection. V Annual Meeting of IBILI
(Coimbra, Portugal)
2013/12/12 Neuropeptide Y in the retina: neuromodulation and neuroprotection. V Annual Meeting of IBILI
(Coimbra, Portugal)
2013/10/25 Role of adenosine A2A receptor modulation in the control of retinal neuroinflammation. 4th PF2MUC Symposium “Personalized Medicine: Myth or Reality?"
(Coimbra, Portugal)
2013/10/11 Adenosine A2A receptor blockade decreases retinal neuroinflammation. Inter-University Doctoral Programme in Ageing and Degeneration of Complex Biological Systems
(Coimbra, Portugal)
2013/09/18 Neuropeptide Y Y1 receptor is neuroprotective and modulates microglia reactivity in the rat retina. EVER 2013
(Nice, França)
2013/09/08 Adenosine A2A receptor blockade and caffeine decrease retinal neuroinflammation. Neuroinflammation - satellite symposium to the regional FENS meeting
(Prague, República Checa)
2013/09/03 Neuropeptide Y protects ganglion cells against excitotoxicity and modulates microglia activation in the rat retina. ISOCB/Ocular Cell Biology Conference
(Oxford, Reino Unido)
2013/05/30 Adenosine A2A receptor modulates LPS-induced neuroinflammation in the retina. XIII Meeting of the Portuguese Society for Neuroscience (SPN)
(Luso, Portugal)
2013/05/30 Neuropeptide Y modulates retinal ganglion cell activity and protects retinal ganglion cell against excitotoxicity. XIII Meeting of the Portuguese Society for Neuroscience (SPN)
(Luso, Portugal)
2013/05/30 Activation of adenosine A3 receptor protects retinal ganglion cells from ischemia-reperfusion injury. XIII Meeting of the Portuguese Society for Neuroscience (SPN)
(Luso, Portugal)
2013/03/03 Adenosine A3 receptor agonist prevents retinal ganglion cell degeneration. 10th International Symposium on Ocular Pharmacology and Therapeutics
(Paris, França)
2013 Neuropeptide Y receptor Y1 modulates microglia activation in the rat retina. XIII Meeting of the Portuguese Society for Neuroscience (SPN)
(Luso, Portugal)
2010/12/07 Invited Speaker - Impairment of the glutamatergic system in the diabetic retina? Evidences from animal and in vitro models. III Colóquio Luso-Brasileiro de Neuroquímica
(Niterói, Brasil)
2009/12/11 Invited Speaker - Neurodegeneration in diabetic retinopathy: the role of glutamate. 1st Annual Meeting of IBILI
(Coimbra, Portugal)
2009/04/17 Invited Speaker - Neurodegeneration in diabetic retinopathy: the role of glutamate. IX Jornadas de Análises Clínicas e Saúde Pública
Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2007/12/16 Apoptosis-inducing factor mediates high glucose-induced cell death in retinal neural cells. 4th Center for Neuroscience Annual Meeting
(Cantanhede, Portugal)
2006/12/10 Tauroursodeoxycholic Acid (TUDCA) Protects Rat Retinal Neural Cells from Cell Death Induced by High Glucose. XVth Congress of Biochemistry
(Aveiro, Portugal)
2005/12/18 High glucose causes caspase-independent apoptotic cell death in retinal neural cells. 2nd Joint Meeting of Graduate Programmes on Biosciences
(Tomar, Portugal)
2005/08/27 GluR2 upregulation as a protective mechanism against high glucose-induced toxicity. Third Wierzba Conference – glutamate in CNS metabolism and neurotransmission: interactions at the inter- and intracellular level
(Wierzba, Polónia)
2005/06/23 High glucose decreases Ca2+ permeability of AMPA receptors and alters calcium homeostasis in retinal neural cells. International Meeting of Ophthalmology
(Coimbra, Portugal)
2005/05/27 High glucose alters Ca2+-permeable AMPA receptors and calcium homeostasis in retinal neural cells. 15th Meeting of the European Association for the Study of Diabetes – Eye Complications Study Group (EASDec)
(Coimbra, Portugal)
2005/05/19 GluR2 Upregulation: Protection Against High Glucose-Induced Toxicity in Retinal Neural Cells? 9th Meeting of the Portuguese Society for Neurosciences
(Luso, Portugal)
2004/12/18 Hyperglycemia and diabetes change AMPA and KA receptor subunits expression and deregulate calcium homeostasis in retinal neurons. 1st Joint Meeting of Graduate Programmes on Biosciences
(Porto, Portugal)
2004/11/17 Neuropeptide Y (NPY) and NPY receptors in rat retina. IV Congresso de Investigação em Medicina
(Coimbra, Portugal)
2004/09/23 Hyperglycemia upregulates GluR2 subunit and deregulates calcium homeostasis in retinal neurons. 2nd Center for Neuroscience Annual Meeting
(Luso, Portugal)
2003/09/26 Mechanisms of neurodegeneration in diabetic retinopathy: role of glutamate. 1st Center for Neuroscience Annual Meeting
(Curia, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2022/02/14 - Atual Role of Piezo1 activation in microglia reactivity
Orientador
Química Medicinal (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/02/10 - Atual Assessment of neuroprotective therapeutic strategies for the treatment of animal models of retinal neurodegenerative diseases
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/02/01 - Atual Research and Development activities in the field of Vision Sciences involving animal research
Orientador de Beatriz Maria Lemos Ormonde
Universidade de Coimbra Faculdade de Medicina, Portugal

Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Portugal
2021/02/01 - Atual Evaluation of the neuroprotective therapeutic strategies for the treatment of neurodegenerative retinal diseases
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/11/11 - Atual Management and Technical support em Animal Facilities
Orientador de Miguel Angelo Morgado Teixeira
Universidade de Coimbra Faculdade de Medicina, Portugal

Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Portugal
2019/09/01 - Atual Influence of elevated hydrostatic pressure on Muller cells phenotype: do microglia-derived microvesicles play a role?
Orientador de Magda Ferreira Rodrigues
Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/09/01 - Atual Impact of caffeine consumption on retinal alterations induced in the retina in an animal model of type 1 diabetes
Orientador de Miguel Angelo Morgado Teixeira
Experimental Pathology (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09/01 - Atual Deadly delivery: unraveling the contribution of microglial exosomes to retinal degeneration in glaucoma
Orientador de Inês Sofia Dinis Aires
Inter-University Doctoral Program in Aging and Chronic Diseases (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/09/01 - Atual Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma
Orientador de Raquel Sofia Freitas Boia
Inter-University Doctoral Program in Aging and Chronic Diseases (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/03/02 - 2022/01/31 Studying the contribution of Müller cell extracellular vesicles in glaucoma: focusing on retinal ganglion cell protection
Orientador de Xandra Pereiro Díez
Programa postdoctoral, de perfeccionamiento de personal investigador Doctor (Outra)
Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Portugal

Gobierno Vasco Departamento de Educación, Espanha
2016/08/01 - 2019/06/30 Fellow in the Project "Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma"
Orientador de Joana Margarida Cardoso Serra Martins
Project funded by Fundação para a Ciência e a Tecnologia (Ref: PTDC/NEU-OSD/3123/2014) (Outra)
Universidade de Coimbra, Portugal
2019/01/01 - 2019/04/30 CNS response to a local injury
Coorientador de José María Cabrera Maqueda
Supervision of the period in Portugal (Doutoramento)
Instituto Murciano de Investigación Biosanitaria, Espanha

Universidad de Murcia Facultad de Medicina, Espanha
2017/09/01 - 2019/03/07 Assessing the safety profile of biodegradable poly(e-caprolactone) implants - effect on microglia-mediated neuroinflammation
Orientador de Joana Cláudia Ferreira da Silva
Pharmaceutical Biotechnology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/06/01 - 2017/09/30 Protection of retinal ganglion cells in experimental models of glaucoma
Coorientador de Fernando Lucas Ruiz
Supervision of the period in Portugal (Doutoramento)
Universidad de Murcia Facultad de Medicina, Espanha

Instituto Murciano de Investigación Biosanitaria, Espanha
2016/09/01 - 2017/09/26 Analysis of the immune response in mice immunized with antigens of the protozoan parasite neospora caninum
Orientador de Ricardo Alexandre Fróis Martins
Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09/01 - 2017/09/12 A novel AAV-based mouse model of Machado-Joseph Disease
Orientador de Miguel Monteiro Lopes
Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09/01 - 2016/12/31 Fellow in the Project "Managing inflammation in diabetic retinopathy by adenosine A2A receptor blockade"
Orientador de Maria Helena Bica Madeira
Project funded by Bayer Health Care (Outra)
Universidade de Coimbra, Portugal
2016/08 - 2016/09 Mediators of inflammation using quantitative polymerase chain reaction
Coorientador de Caridad Galindo Romero
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/12/01 - 2016/08/31 Fellow in the Project "Managing inflammation in diabetic retinopathy by adenosine A2A receptor blockade"
Orientador de Inês Sofia Dinis Aires
Project funded by Bayer Health Care. (Outra)
Universidade de Coimbra, Portugal
2011/01/01 - 2016/06/22 Controlling neuroinflammation in the retina through A2AR modulation: potential therapeutic implication in glaucoma
Orientador de Maria Helena Bica Madeira
Degeneration of Complex Biological Systems (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/11/01 - 2015/09/30 Fellow in the Project "From neuroinflammation control to neuroprotection: blocking adenosine A2A receptor for the treatment of glaucoma"
Orientador de Raquel Sofia Freitas Boia
Project funded by Fundação para a Ciência e a Tecnologia (Ref: PTDC/BIM-MEC/0913/2012) (Outra)
Universidade de Coimbra, Portugal
2014/09/01 - 2015/09/11 Microglia reactivity under elevated hydrostatic pressure conditions: is there a role for adenosine and adenosine A2A receptors?
Orientador de Ana Catarina Rodrigues Neves
Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/01 - 2014/12 Neuropeptide Y: a potential neuroprotective agent for the treatment of glaucoma?
Coorientador de Dan Brudzewsky
FCT Fellow (Ref: SFRH/BPD/69123/2010/2010) (Outra)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09/01 - 2014/09/22 Involvement of the NPY system in the inflammatory resposnses mediated by retinal microglial cells: modulation by stiagliptin
Coorientador de Sandra Raquel Félix Guimarães Correia
Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09 - 2014/09 Role of A2A receptor in pressure-induced retinal microglia reactivity
Orientador de Inês Sofia Dinis Aires
Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/09/01 - 2013/09/06 Modulation of pro-inflammatory response of retina by adenosinergic system
Orientador de Raquel Sofia Freitas Boia
Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/09/01 - 2011/12/05 Tauroursodeoxycholic acid: a novel neuroprotective drug in diabetic retinopathy?
Orientador de Alexandra Menezes Martins
Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/09/01 - 2011/11/23 Role of adenosine A2A receptor in controlling neuroinflammation mediated by retinal microglial cells
Orientador de Maria Helena Bica Madeira
Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2017/12/21 - Atual Second Meeting on Biomedical Research @ UC, Coimbra, Portugal (2017/12/21)
Encontro (Membro da Comissão Organizadora)
2014/12/17 - Atual “5th PF2MUC Symposium – Zoom in Microglia", Coimbra, Portugal (2014/12/17)
Simpósio (Coorganizador)
2013/10/25 - Atual “4th PF2MUC Symposium – Personalised Medicine: Myth or Reality?", Coimbra, Portugal (2013/10/25)
Simpósio (Membro da Comissão Organizadora)
2012/10/26 - Atual "2nd PF2MUC Symposium – Changing Paradigms of Science", Coimbra, Portugal (2013/10/26)
Simpósio (Membro da Comissão Organizadora)
2021/11/30 - 2021/11/30 V Symposium of The Portuguese Glial Network - Glial cells at the crossroad of health and disease (2021/11/30 - 2021/11/30)
Encontro (Coorganizador)
2021/05/24 - 2021/05/25 Retreat of the Centre for Innovative Biomedicine and Biotechnology (CIBB) Neuroscience and Disease research line, virtual, Coimbra, May 24-25. (2021/05/24 - 2021/05/25)
Encontro (Coorganizador)
Universidade de Coimbra, Portugal
2021/05/06 - 2021/05/06 Workshop "Communication in Animal Experimentation" (2021/05/06 - 2021/05/06)
Oficina (workshop) (Coorganizador)
Universidade de Coimbra, Portugal
2019/07/10 - 2019/07/13 Symposium "Contribution of glial extracellular vesicles to neurodegenerative diseases”, XIV European Meeting on Glial Cells in Health and Disease, Porto (2019/07/10 - 2019/07/13)
Simpósio (Coorganizador)
2018/09/09 - 2018/09/13 Symoposim “The emerging roles of extracellular vesicles in health and diseases of the eye” at the XXIII Biennial Meeting of the International Society for Eye Research (ISER), Belfast (2018/09/09 - 2018/09/13)
Simpósio (Coorganizador)
2015/03/30 - 2015/04/01 “Training School in Experimental Design and Statistical Analysis”, Coimbra, Portugal (2015/03/30 - 2015/04/01)
Oficina (workshop) (Coorganizador)
2013/05/30 - 2013/06/01 XII Portuguese Neurocience Society meeting, Luso, Portugal (2013/05/30 - 2013/06/01)
Encontro (Membro da Comissão Organizadora)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2018 - 2019 Participation in outreaching activities as part of program "European Researchers' Night"
Universidade de Coimbra, Portugal
2009 - 2019 Participation in outreaching activities as part of program "Brain Awareness Week"
Universidade de Coimbra, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2021/09/21 Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma
Orientador
Raquel Sofia Freitas Boia (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/06/25 The role of TRAP1 in RPE under oxidative stress
Arguente
Inês Ramos Rego (Outro)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/02/25 Anti-inflammatory effect of carbon monoxide on the neuron-microglia bidirectional communication
Arguente principal
Nuno Ricardo Lucas Soares (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09/20 Understanding the role of pancreatic cancer metastasis exosomes in its establishment, survival and growth at secondary organs
Arguente
Patricia Fernanda Carneiro Vieira (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/09/16 Xenotransplante de tecido ovárico bovino como modelo para testar novas drogas, analisar a angiogénese, a depleção prematura e a dinâmica folicular
Arguente
Ana Rita Faria Azevedo (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/05/03 Understanding the potential of pdmaema-based vectors for gene therapy of the retina
Arguente principal
Diogo Miguel Barros Bitoque (Doutoramento)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017/12/15 Bringing light to darkness: What is the role of synucleins in retinal neurodegeneration?
Arguente principal
Gabriela Vilaça Cruz Cerqueira Dos Santos (Mestrado)
Universidade de Aveiro, Portugal
2017/09/25 Development of ocular implants using a supercritical fluid foaming/mixing methodology
Arguente principal
Sara Cristina Duarte Bizarro (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/03/17 In vivo Automatic Cataract Detection and Classification using the Ultrasound Technique
Arguente
Luís Miguel da Luz Caixinha Duarte (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09/21 Amyloid-beta peptide-evoked Src signaling and redox changes in hippocampal cells
Arguente principal
Lígia Vanessa Rocha Fão (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/19 miRNAs and risk gene interactions in Alzheimers's disease: from mechanisms to therapeutics
Arguente principal
Ana Rafaela Gomes Soares Oliveira (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/09 Influenza A virus modulation of mitochondria dynamics
Vogal
Maria Inês Martins Veríssimo (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06/22 Controlling neuroinflammation in the retina through A2AR modulation: potential therapeutic implication in glaucoma
Presidente do júri
Maria Helena Bica Madeira (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09/23 Desenvolvimento de lentes de contacto terapêuticas com capacidade de oxigenação melhorada
Arguente principal
Sónia Filipa Xavier Mendes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09/22 Microglia as cellular targets for immunomodulation during neurodevelopment
Arguente
Sónia Raquel Nunes Henriques (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09/15 Adenosine A2A Receptors and Stress-induced alterations in the rat ventral striatum
Arguente
Inês Margarida Dias Cabaço Amaral (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09/11 The impact of elevated hydrostatic pressure in microglia : chances in the adenosinergic system and inflammatory responses
Vogal
Ana Catarina Rodrigues Neves (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/07/21 The Adenosinergic System in the Context of Diabetic Retinopathy: From Alterations to Modulation
Arguente
Joana Rita Domingues Vindeirinho (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2015/05/29 Modulation of retinal ganglion cell function and implications for neuroprotection
Arguente
João Filipe da Costa Martins (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/12/18 Investigate the effect mediated by A2AR on microglia reactivity in retinal neural cell cultures exposed to elevated hydrostatic pressure
Orientador
Joana Filipa Leandro Horta (Outro)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2014/09/23 Role of adenosine A2A receptor in pressure-induced retinal microglia reactivity
Orientador
Inês Sofia Dinis Aires (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/07/14 Brain dysfunction and cell death in type 2 diabetes : A neuroprotective role for the peripheral treatment with Exendin-4
Arguente principal
Inês Carolina de Sousa Madeira Antunes Sebastião (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/12/03 Evaluation of the potential protective effects of adenosine A3 receptor in retinal ganglion cell degeneration
Arguente
Joana Margarida Fernandes Galvão (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09/06 Modulation of pro-inflammatory response of retina by adenosinergic systems : neuroinflammation/neuroprotection
Orientador
Raquel Sofia Freitas Boia (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2022 - Atual Associate Editor in the section Non-Neuronal Cells in Frontiers in Cellular Neuroscience Frontiers
2022 - Atual Associate Editor in the section Neuropharmacology in Frontiers in Pharmacology and Frontiers in Neuroscience Frontiers
2022 - Atual Guest Associate Editor in the Topic “Molecular and cellular players of axonal regeneration in injured CNS” in Frontiers in Neuroscience
2020/11/10 - Atual International Journal of Molecular Sciences, Special Issue "Retinal Neurodegenerative Diseases: Molecular Targets Driving Neuroinflammation and Neuroprotection" (ISSN 1422-0067) MDPI
2019 - Atual Special issue "Retinal Ganglion Cells" in International Journal of Molecular Sciences (1422-0067) MDPI AG
2017/01/01 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2013/01/01 - Atual Cell Biology
2013/01/01 - Atual Journal of Ophthalmology Hindawi
2016 - 2016 Special Issue "Microglia in Health and Disease: A Double-Edged Sword" in Mediators of Inflammation (1466-1861) Hindawi Limited

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2021/02/13 - Atual COST external expert: – Contribute to the evaluation of COST Open Call proposals. – Participate in the assessment of Action results and outcomes.
Avaliador
COST (European Cooperation in Science and Technology), Bélgica COST (European Cooperation in Science and Technology)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/09/01 - Atual Immunology I Mestrado Integrado em Medicine (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/03/02 - Atual Seminar entitled “Animal research in Vision Sciences and Ophthalmology” presented for the Curricular Unit “Multidisciplinary Seminars” Degree in Orthoptics (Bacharelato) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2017/04/19 - Atual Lecture entitled "Putting pressure on experimental models to study glaucoma" for the advanced course "Animal models of Human diseases" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/05/21 - Atual Lecture entitled "Animal research in Vision Sciences and Ophthalmology" for the Curricular Unit "Research in Orthoptics I" Degree in Orthoptics (Bacharelato) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2016/05/05 - Atual Lecture entitled "Putting pressure on experimental models to study glaucoma" for the advanced course "Animal models of Human diseases" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/02/12 - Atual Seminar entitled “Targeting adenosine receptors as protective strategies in retinal degenerative diseases” CNC.IBILI seminars Universidade de Coimbra, Portugal
2014/03/24 - Atual Lecture entitled "Models and Experimental Techniques in Vision Sciences" for the advanced course "Vision Sciences" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2013/10/17 - Atual Lecture entitled "Targeting adenosine receptors to treat retinal degenerative diseases", for the Curricular Unit “Foundations of Science” Masters in Biomedical Research (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2013/02/14 - Atual Co-preparation of the super seminar "Modulation of neuroinflammation: strategies to prevent neural dysfunction and degeneration" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2012/04/19 - Atual Co-coordination of the super seminar "Direct and indirect neuroprotective strategies to treat retinal degenerative diseases" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2012/04/11 - Atual Lecture entitled "Animal models of retinal diseases" for the advanced course "Animal models of Human diseases" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2011/03/15 - Atual Lecture entitled "Impairment of the glutamatergic system in the diabetic retina?" for the advanced course "Translational Research in Retinal Degenerative Diseases" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/03/19 - Atual Lecture entitled "Electroretinography: Measurement of the electrical activity of the retina", for students of the Abrantes Secondary School (Ensino secundário) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/03/16 - Atual Lecture entitled "How to measure the electric activity of the retina?" for students of the Amato Lusitano Secondary School (Castelo Branco) (Ensino secundário) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/03/16 - Atual Lecture entitled "Eletroretinography: Measurement of the electrical activity of the retina", for students of the Colegio Interna dos Carvalhos (Vila Nova de Gaia) (Ensino secundário) Universidade de Coimbra Faculdade de Medicina, Portugal
2009/02/10 - Atual Lecture entitled "Diabetic retinopathy: beyond microvascular dysfunction" for the Advanced Course "Visual Neuroscience: from photons to perception" Doctoral Program in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006 - Atual Lecture entitled "Glutamate in the retina" for the Curricular Unit "Neurobiology of Vision" Masters in Vision Sciences (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2006 - Atual Lecture entitled "Is glutamate involved in diabetic retinopathy?" for the Curricular Unit "Neurobiology of Vision" Masters in Vision Sciences (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2004 - Atual Lecture entitled "Glutamate in the retina" for the Curricular Unit "Neurobiology of Vision" Masters in Vision Sciences (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2004 - Atual Lecture entitled "Is glutamate involved in diabetic retinopathy?" for the Curricular Unit "Neurobiology of Vision" Masters in Vision Sciences (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2019/05/20 - 2019/05/24 Lecture entitled "Putting pressure on experimental models to study glaucoma" for the advanced course "Animal models of Human diseases" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2019/02/25 - 2019/03/01 Lecture entitled "Fundamental research in Vision Sciences: experimental models and techniques" for the advanced course "Vision Sciences " Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2019/02/25 - 2019/03/01 Lecture entitled "Is neuroinflammation control the strategy for the treatment of retinal degenerative diseases?" for the advanced course "Vision Sciences " Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11/07 - 2018/11/08 Lecture entitled “The why’s and how’s of animal models in Vision Science research” for the Curricular Unit Research Methods and Techniques Master Course in Biomedical Research (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11/07 - 2018/11/08 Lecture entitled “Neuroinflammation and neuroprotection: is there an opportunity for retinal neurodegenerative diseases?” for the Curricular Unit Research Methods and Techniques Master Course in Biomedical Research (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/03/12 - 2018/03/16 Lecture entitled "Fundamental research in Vision Sciences: experimental models and techniques" for the advanced course "Vision Sciences" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/03/12 - 2018/03/16 Lecture entitled Is neuroinflammation control the strategy for the treatment of retinal degenerative diseases?" for the advanced course "Vision Sciences" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/03/05 - 2018/03/09 Lecture entitled "Putting pressure on experimental models to study glaucoma" for the advanced course "Animal models of Human diseases" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/01/19 - 2018/01/19 Seminar entitled “Targeting adenosine receptors in retinal degenerative diseases: From neuroinflammation to neuroprotection” presented at “XIV Seminarios Fisiología y Patología Ocular: Conceptos Actuales” Universidad Complutense de Madrid Facultad de Óptica y Optometría, Espanha
2017/03/06 - 2017/03/10 Lecture entitled "Experimental models and techniques for research in Vision Sciences and Ophthalmology" for the advanced course “Vision Sciences” Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/03/06 - 2017/03/10 Lecture entitled "From neuroinflammation control to neuroprotection of retinal ganglion cells: is it a strategy for the treatment of glaucoma?" for the advanced course “Vision Sciences” Doctoral Program in Health Sciencesv (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/02/29 - 2016/03/04 Lecture entitled "Models and Experimental Techniques in Vision Sciences" for the advanced course "Vision Sciences" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/02/29 - 2016/03/04 Lecture entitled "Neuroinflammation in Glaucoma: Inhibition of Microglia as a Potential Therapeutic Strategy" for the advanced course "Vision Sciences" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/03/09 - 2015/03/13 Lecture entitled "Models and Experimental Techniques in Vision Sciences" for the advanced course "Vision Sciences" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/03/09 - 2015/03/13 Lecture entitled "Neuroinflammation in Glaucoma: Inhibition of Microglia as a Potential Therapeutic Strategy" in the advanced course "Vision Sciences" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2009/02/09 - 2009/02/13 Lecture at the Advanced Course entitled "Visual Neuroscience: from photons to perception" Doctoral Program in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2009 Curricular Units “Psychophysiology”, “Ethology” and “Neuropsychology” Degree in Psychology (Bacharelato) Universidade Internacional da Figueira da Foz, Portugal

Membro de associação

Nome da associação Tipo de participação
2021/12/01 - Atual Portuguese Glial Network Board member
2017 - Atual Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS, Spain) Member
2015 - Atual European Association for Vision and Eye Research (EVER, Belgium) Member
2015 - Atual European Association for the Study of Diabetes (EASD, Germany) Member
2012 - Atual International Society for Eye Research (ISER, USA) Member
2008 - Atual Portuguese Society for Neuroscience (SPN) Member
2004 - Atual Association for Research in Vision and Ophthalmology (ARVO, USA) Member
2003 - Atual Portuguese Biochemical Society Member

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2015 - Atual PhD Thesis committee of the Inter-University Doctoral Program in Aging and Chronic Diseases
Consultor
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade do Minho Escola de Medicina, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2022 - Atual Project evaluator for the National Science Centre, Poland
2021 - Atual Project Evaluator for the Career Development Award Medical Research Council, Reino Unido
2021 - Atual Project evaluator for the NWO Talent scheme – Veni 2021 Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Países Baixos
2020 - Atual Project evaluator for the Research Projects in Neuroscience 2020 Fundación Tatiana Pérez de Guzmán el Bueno, Espanha
2019/11/01 - 2020/01/06 Project Evaluator for the Research Grants Programme - Individual Proposal Deutsche Forschungsgemeinschaft, Alemanha
2019 - 2019 Member of the jury for the selection of one Fellow in Scientific Research for the project "Evaluation of the effects of a FAAH inhibitor, BIA 12-3126, on the retina". Universidade de Coimbra Faculdade de Medicina, Portugal
2019 - 2019 Member of the jury for the selection of one Fellow in Scientific Research for the project BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias (CENTRO-01-0145-FEDER-000008) Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2016 President of the jury for the selection of one Scientific Research Fellow to work in the project "Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma” funded by FCT Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2015 Member of the jury of the selection of one Scientific Research Fellowship for the project "Work in the field of vision sciences, for morphological and functional evaluation of the retina and choroid "funded by the pharmaceutical company Novartis Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2015 President of the jury for the selection of one Scientific Research Fellow, to work in the project "Managing inflammation in diabetic retinopathy by adenosine A2A receptor blockade" funded by Bayer Health Care Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2013 Member of the jury for the selection of one Fellow in Scientific Research for the project funded by the Foundation for Science and Technology with the reference PTDC/NEU-OSD/1113/2012 Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2013 President of the jury for the selection of one Scientific Research Fellow for the project funded by the Foundation for Science and Technology with the reference PTDC/BIM-MEC/0913/2012 Universidade de Coimbra Faculdade de Medicina, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2022 - Atual Frontiers in Cell and Developmental Biology (2296-634X) Frontiers Media S.A.
2022 - Atual Frontiers in Pharmacology (1663-9812) Frontiers Media S.A.
2021 - Atual ACS Chemical Neuroscience ACS Publications
2021 - Atual Eye and Brain (1179-2744) Dove Press Open Access Publisher
2021 - Atual FEBS Letters (0014-5793) Wiley Online Library
2021 - Atual Frontiers in Physiology (1664-042X) Frontiers Media S.A.
2021 - Atual Histology and Histopathology (1699-5848) University of Murcia (Spain)
2021 - Atual International Journal of Molecular Sciences (1422-0067) MDPI
2020 - Atual Expert Opinion On Therapeutic Targets (1472-8222) Taylor & Francis
2020 - Atual Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media S.A.
2020 - Atual Gene Therapy ( 0969-7128) Nature
2019 - Atual Annals of the Brazilian Academy of Sciences (0001-3765) Academia Brasileira de Ciencias
2019 - Atual Frontiers in Neuroscience (1662-453X) Frontiers Media S.A.
2018 - Atual Cytokine (2590-1532) Elsevier
2018 - Atual Journal of Neurochemistry (0022-3042) Wiley Online Library
2017 - Atual ALTEX - Alternatives to Animal Experimentation (1868-596X) Springer
2017 - Atual British Journal of Pharmacology (0007-1188) Wiley Online Library
2016 - Atual Biomedicine Hub (2296-6870) Karger Publishers
2016 - Atual International Journal of Experimental Pathology (1365-2613) Wiley Online Library
2015 - Atual Brain Research (0006-8993) Elsevier
2015 - Atual Disease Models and Mechanisms (1754-8403) The Company of Biologists
2015 - Atual Experimental Eye Research (0014-4835) Elsevier
2014 - Atual Clinical and Experimental Ophthalmology (1442-6404) Wiley Online Library
2014 - Atual European Journal of Pharmacology (0014-2999) Elsevier
2014 - Atual Journal of Neuroinflammation (1742-2094) Springer Nature
2013 - Atual Acta Neuropathologica (0001-6322) Springer Journal
2013 - Atual Investigative Ophthalmology & Visual Science (IOVS) (1552-5783) Association for Research in Vision and Ophthalmology (ARVO)
2012 - Atual Current Eye Research (0271-3683) Taylor & Francis
2011 - Atual Clinical Ophthalmology (1177-5483) Dove Press Open Access Publisher
Distinções

Prémio

2022 ImmunoTools special AWARD
ImmunoTools GmbH, Alemanha
2018 ImmunoTools Special Award - ImmunoTools GmbH, Germany (Project “The impact of retinal exosomes in glaucoma – focus on neuroinflammation”)
2018 ImmunoTools Special Award
ImmunoTools GmbH, Alemanha
2016 Registration fee waiver - Scholarship awarded to Maria Madeira (PhD student under my supervision) to attend the “European Neuroscience Conference by Doctoral Students” (ENCODS), Helsingor, Denmark
2016 FENS-IBRO/PERC travel grant - Travel Grant awarded to Maria Madeira (PhD student under my supervision) to attend the “FENS Forum 2016”, Copenhague, Denmark
2015 Travel grant - Newcastle University Institute for Aging, Travel grant to attend the “6th Annual Alliance for Healthy Aging Conference - Interventions to Slow Down Aging”
2014 ImmunoTools Special Award - ImmunoTools GmbH, Germany (Project “Role of adenosine A2A receptor in pressure-induced retinal microglia reactivity”)
2014 EMBL Advanced Training Centre Corporate Partnership Programme - Travel grant (500 EUR) to attend the meeting “Microglia: Guardians of the Brain”, organized by the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
2014 Best Photo in Vision Research and Ophthalmology (5th place), Image from PhD student Maria Madeira under my supervision
2014 Best Poster Award - Poster presented at XVIII Congress of the Portuguese Biochemical Society (SPB)
2013 IT-Box-Cy55M Award 2013 - ImmunoTools GmbH, Germany
2013 Runner up prize - Poster presented at “UCL Institute of Ophthalmology Poster Day”, London
2013 Best Scientific Image Award - Image from PhD student Maria Madeira under my supervision
2013 Best Oral Communication - “Role of adenosine A2A receptor modulation in the control retinal neuroinflammation”. Oral presentation at the 4th PF2MUC symposium.
2012 3rd best poster award - Poster presented at “UCL Institute of Ophthalmology Poster Day”, London
2012 Best poster award - Poster presented at “IV Annual Meeting of IBILI”, Coimbra, Portugal
2011 Best poster award - Poster presented at “1st PF2MUC Symposium”, Coimbra, Portugal
2003 Advanced course grant awarded by OTAN/NATO to attend the Advanced course “Frontiers in Neurodegenerative Disorders and Aging: Fundamental Aspects, Clinical Perspectives and New Insights”, Antalya, Turkey

Outra distinção

2016 Registration fee waiver
2016 FENS-IBRO/PERC travel grant
2015 Vote of Praise - Municipality of Anadia
2015 Travel grant
2015 Vote of Praise
2014 ImmunoTools Special Award
2014 EMBL Advanced Training Centre Corporate Partnership Programme
2014 Best Photo in Vision Research and Ophthalmology (5th place)
2014 Best Poster
2014 Best Photo in Vision Research and Ophthalmology (2nd place)
2013 IT-Box-Cy55M Award 2013
2013 Runner up prize
2012 3rd best poster award
2012 Best poster award
2011 Best poster award
2003 Advanced course grant