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Ângela Inácio is a Postdoctoral Researcher at the Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Portugal. She graduated in Biology from the University of Coimbra in 2007 and obtained a PhD in Biosciences from the same University in 2013. During her PhD, she conducted research on the potential use of surfactants in the prophylaxis of sexually transmitted infections. She was a postdoctoral fellow at the Interdisciplinary Centre for Marine and Environmental Research (CIIMAR), University of Porto, where she worked on the antibacterial and antifungal screening of compounds isolated from marine organisms. The focus of her research included antimicrobial resistance mechanisms and the transfer of multi-drug-resistant genes between intermingled ecological niches. In her postdoctoral position at the laboratory of Professor Paulo Costa, she was responsible for monitoring the research output of all team members, integrating their results with her own, and managing various resources in the lab to ensure that all deadlines and milestones were met. During this period, she gained extensive experience in drug screenings. Motivated by a profound interest in neuroscience research, Ângela Inácio joined the Synapse Biology Lab at CNC-UC in 2017. She was awarded a postdoctoral fellowship by the Portuguese Foundation for Science and Technology (FCT) to conduct research on synaptic dysfunction in neurodevelopmental disorders, under the mentorship of Prof. Ana Luísa Carvalho. The focus of her research is on genetic defects associated with neurodevelopmental disorders, specifically exploring how genes coding for synaptic proteins may impact synaptic function and brain connectivity. Ângela employs a combination of molecular genetics, animal behaviour, and electrophysiological approaches in her work. Her research has recently been published in Molecular Psychiatry (co-first author). Since 2021, she has held the position of a junior researcher at CNC. Ângela is a co-author of 17 original publications in international, peer-reviewed journals, with 5 of them as the first author. Since graduating, Ângela Inácio has supervised two master theses and one undergraduate student project. She has also co-supervised four master students, mentored several trainees and master students in laboratory rotations, and served as the main examiner for one master thesis. Additionally, she completed an animal experimentation course accredited by DGAV and an extensive hands-on electrophysiology course at the University of Göttingen in Germany. Ângela has taught practical classes on electrophysiology and 3D morphometric analysis for students in the Master's degree in Cellular and Molecular Biology, the PhD Programme in Experimental Biology and Biomedicine at the University of Coimbra (Portugal), and the ETN Synaptic Dysfunction in Neuropsychiatric Disorders (Syn2Psy Network School). She has also taught practical classes for students in the Bachelor's Degree in Biomedical Engineering, Biology, and Medicinal Chemistry. In 2022, she was an instructor at the Bordeaux School of Neuroscience for the workshop "Introduction to Experimental Neuroscience." Ângela has served as a reviewer for the Journal of Neurochemistry, the British Journal of Pharmacology, eLife, and the Journal of Neuroscience. She actively participated in preparing grant applications for research funding from national and international agencies. Additionally, Ângela collaborates with the CNC Outreach Programme, regularly participating in science communication activities as part of Ciência Viva, Brain Awareness Week, and European Researchers' Night initiatives.
Identificação

Identificação pessoal

Nome completo
Ângela Rosalina Sanches Inácio

Nomes de citação

  • Inácio, Ângela S.

Identificadores de autor

Ciência ID
E613-E64A-FE36
ORCID iD
0000-0002-5401-8455
Google Scholar ID
https://scholar.google.com/citations?user=R0MXb3EAAAAJ&hl=en
Researcher Id
AAE-1653-2020
Scopus Author Id
55919620700

Endereços de correio eletrónico

  • ainacio@cnc.uc.pt (Profissional)

Telefones

Fax
  • (+351) 239 822 77 (Profissional)
Telefone
  • (+351) 239 820 19 (Profissional)

Moradas

  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Rua Larga, Faculdade de Medicina, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Naturais - Ciências Biológicas - Microbiologia
Formação
Grau Classificação
2017/09/26 - 2017/10/06
Concluído
Modular structure training in laboratory animal science – Rodents, Category C (Pós-Graduação)
CNC.IBILI, Portugal
19
2008/01/02 - 2013/03/14
Concluído
Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"A systematic investigation of the potential use of surfactants as microbicides: implications for surfactant use in the prophylaxis of sexually transmitted infections." (TESE/DISSERTAÇÃO)
Aprovado com Distinção e Louvor
2002/09/23 - 2007/07/20
Concluído
Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
17
Produções

Publicações

Artigo em revista
  1. Schmidt, Jeannette; Inácio, Ângela; Ferreira, Joana S; Serrenho, Débora; Socodato, Renato; Beltrão, Nuno; Ribeiro, Luís F; et al. "[PREPRINT] Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission". bioRxiv (2024):
    Submetido • 10.1101/2024.02.29.582472
  2. Rodrigues, B.; Leitão, R.; Santos, M.; Trofimov, A.; Silva, M.; Inácio, Â.; Abreu, M.; et al. "[PREPRINT] MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". Research Square (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85175990038&partnerID=MN8TOARS.
    10.21203/rs.3.rs-3405749/v1
  3. Inês C. Rodrigues; NL Santos-Ferreira; Daniela Silva; Carla Chiquelho da Silva; Ângela S. Inácio; Nascimento M.S.J.; Paulo Martins da Costa. "A One-Year Systematic Study to Assess the Microbiological Profile in Oysters from a Commercial Harvesting Area in Portugal". Microorganisms 11 2 (2023): 338-338. http://dx.doi.org/10.3390/microorganisms11020338.
    10.3390/microorganisms11020338
  4. Caldeira, G.L.*; Inácio, A.S.*; Beltrão, N.; Barreto, C.A.V.; Rodrigues, M.V.; Rondão, T.; Macedo, R.; et al. "Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". Molecular Psychiatry 27 5 (2022): 2457-2469. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125693853&partnerID=MN8TOARS.
    10.1038/s41380-022-01487-w
  5. Caldeira, G. L.*; Inácio, Ângela S.*; Beltrão, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, T.; Macedo, R.; et al. "[PREPRINT] Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". bioRxiv (2021):
    doi.org/10.1101/2021.06.08.447333
  6. Santos-Ferreira, Nânci; Mesquita, João Rodrigo; Rivadulla, Enrique; Inácio, Ângela S.; Martins da Costa, Paulo; Romalde, Jesus L.; Nascimento, Maria São José. "Hepatitis E virus genotype 3 in echinoderms: First report of sea urchin (Paracentrotus lividus) contamination". Food Microbiology 89 (2020): 103415. http://dx.doi.org/10.1016/j.fm.2020.103415.
    Publicado • 10.1016/j.fm.2020.103415
  7. Santos-Ferreira, Nânci; Mesquita, João Rodrigo; Rivadulla, Enrique; Inácio, Ângela S.; Nascimento, Maria São José; Romalde, Jesus; Martins da Costa, Paulo. "Norovirus contamination of sea urchins (Paracentrotus lividus): Potential food risk for consumers". Food Control 111 (2020): 107041. http://dx.doi.org/10.1016/j.foodcont.2019.107041.
    10.1016/j.foodcont.2019.107041
  8. Mendes, Ângelo Joel; Santos-Ferreira, Nânci Lúcia; Costa, Francisco Miguel; Lopes, Elizabete Paula; Freitas-Silva, Joana; Inácio, Ângela Sanches; Moreira, Fernando Lopes; da Costa, Paulo Martins. "External contamination of broilers by Campylobacter spp. increases from the farm to the slaughterhouse.". British Poultry Science (2020): http://dx.doi.org/10.1080/00071668.2020.1736264.
    Acesso aberto • Publicado • 10.1080/00071668.2020.1736264
  9. Buttachon, Suradet; Ramos, Alice; Inácio, Ângela; Dethoup, Tida; Gales, Luís; Lee, Michael; Costa, Paulo; et al. "Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Aspergillus candidus KUFA0062". Marine Drugs 16 4 (2018): 119. http://dx.doi.org/10.3390/md16040119.
    Acesso aberto • Publicado • 10.3390/md16040119
  10. Freitas-Silva, J.; Inácio, Â.S.; Mourão, J.; Antunes, P.; Mendes, Â.; de Carvalho, A.P.; Vasconcelos, V.; Peixe, L.; da Costa, P.M.. "Occurrence of mcr-1 in Escherichia coli from rabbits of intensive farming". Veterinary Microbiology 227 (2018): 78-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055912006&partnerID=MN8TOARS.
    Publicado • 10.1016/j.vetmic.2018.10.020
  11. Resende, D.I.S.P.; Pereira-Terra, P.; Inácio, A.S.; Da Costa, P.M.; Pinto, E.; Sousa, E.; Pinto, M.M.M.. "Lichen xanthones as models for new antifungal agents". Molecules 23 10 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85054891121&partnerID=MN8TOARS.
    Acesso aberto • Publicado • 10.3390/molecules23102617
  12. Kumla, D.; Aung, T.S.; Buttachon, S.; Dethoup, T.; Gales, L.; Pereira, J.A.; Inácio, Â.; et al. "A new dihydrochromone dimer and other secondary metabolites from cultures of the marine sponge-associated fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213". Marine Drugs 15 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85039868505&partnerID=MN8TOARS.
    Acesso aberto • Publicado • 10.3390/md15120375
  13. May Zin, W.W.; Buttachon, S.; Dethoup, T.; Pereira, J.A.; Gales, L.; Inácio, Â.; Costa, P.M.; et al. "Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA 0006". Phytochemistry 141 (2017): 86-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019971424&partnerID=MN8TOARS.
    Publicado • 10.1016/j.phytochem.2017.05.015
  14. Inácio, Ângela S.; Nunes, Alexandra; Milho, Catarina; Mota, Luís Jaime; Borrego, Maria J.; Gomes, João P.; Vaz, Winchil L. C.; Vieira, Otília V.. "In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents". Antimicrobial Agents and Chemotherapy 60 6 (2016): 3323-3332. http://dx.doi.org/10.1128/aac.00166-16.
    Acesso aberto • Publicado • 10.1128/aac.00166-16
  15. Inácio, Â.S.; Domingues, N.S.; Nunes, A.; Martins, P.T.; Moreno, M.J.; Estronca, L.M.; Fernandes, R.; et al. "Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: Mechanisms of action and clinical implications in antibacterial prophylaxis". Journal of Antimicrobial Chemotherapy 71 3 (2016): 641-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960839711&partnerID=MN8TOARS.
    Acesso aberto • Publicado • 10.1093/jac/dkv405
  16. Inácio, A.S.; Costa, G.N.; Domingues, N.S.; Santos, M.S.; Moreno, A.J.M.; Vaz, W.L.C.; Vieiraa, O.V.. "Mitochondrial dysfunction is the focus of quaternary ammonium surfactant toxicity to mammalian epithelial cells". Antimicrobial Agents and Chemotherapy 57 6 (2013): 2631-2639. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877862108&partnerID=MN8TOARS.
    Acesso aberto • Publicado • 10.1128/AAC.02437-12
  17. Carreira, B.P.; Morte, M.I.; Lourenço, A.S.; Santos, A.I.; Inácio, A.; Ambrósio, A.F.; Carvalho, C.M.; Araújo, I.M.. "Differential contribution of the guanylyl cyclase-cyclic GMP-protein kinase G pathway to the proliferation of neural stem cells stimulated by nitric oxide". NeuroSignals 21 1-2 (2013): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876114933&partnerID=MN8TOARS.
    Acesso aberto • Publicado • 10.1159/000332811
  18. Inácio, A.S.; Mesquita, K.A.; Baptista, M.; Ramalho-Santos, J.; Vaz, W.L.C.; Vieira, O.V.. "In vitro surfactant structure-toxicity relationships: Implications for surfactant use in sexually transmitted infection prophylaxis and contraception". PLoS ONE 6 5 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79956121318&partnerID=MN8TOARS.
    Acesso aberto • Publicado • 10.1371/journal.pone.0019850
  19. Carreira, B.P.; Morte, M.I.; Inácio, Â.; Costa, G.; Rosmaninho-Salgado, J.; Agasse, F.; Carmo, A.; et al. "Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor". Stem Cells 28 7 (2010): 1219-1230. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954821915&partnerID=MN8TOARS.
    Acesso aberto • Publicado • 10.1002/stem.444
  20. Araújo, I.M.*; Carreira, B.P.*; Pereira, T.; Santos, P.F.; Soulet, D.; Inácio, Â.; Bahr, B.A.; et al. "Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons". Cell Death and Differentiation 14 9 (2007): 1635-1646. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548022118&partnerID=MN8TOARS.
    Acesso aberto • Publicado • 10.1038/sj.cdd.4402171
Tese / Dissertação
  1. Inácio, Ângela S.. "A systematic investigation of the potential use of surfactants as microbicides: implications for surfactant use in the prophylaxis of sexually transmitted infections.". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2013. http://hdl.handle.net/10316/22672.