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Manuel Carrondo: é professor Catedrático Jubilado da FCT NOVA. Tem o titulo de Agregado em Chemical and Biochemical Engineering em 1991 pela Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Fez o Doutoramento em Public Health Engineering em 1979 pelo Imperial College London, e o Mestrado em Public Health Engineering em 1976 pelo Imperial College London e Licenciatura em Engenharia Química em 1971 pela Universidade do Porto Faculdade de Engenharia. Foi Coordenador da Unidade de Investigação iNOVA4Helath entre 2015 e 2023. Fundou em 1989 o iBET, Instituto de Biologia Experimental e tecnologica tendo sido CEO do iBET até 2012. Desde 2012 é Vice-presidente do iBET e responsável pelo Business Development. Fundou a Genibet Pharmaceuticals tendo sido até 2022 seu Chief Scientific Officer (empresa vendida em 2022 à Recipharm). Entre várias distinções recebeu em 2021 o Cell Culture Engineering Excellence Award (Engineering Conferences International. Orientou 35 alunos de doutoramento. Publicou mais de 240 artigos em revistas cientificas especializadas com revisão por pares. É co-autor em 22 livros da especialidade. Actua na área de Ciências da Engenharia e Tecnologias com ênfase em Tecnologias de BioProcessamento em particular no desenvolvimento de Biofarmacos e terapias avançadas (gene and cell thearpies). No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica são: Biopharmaceuticals; Chemical Engineering; Cell based vaccines, VLP´s; Biotechnology; Regenerative medicine; Bioengineering; Bio-economy; Sustainability; gene therapy; Molecular Medicine; Molecular terapia celular; Anticorpos; Vacinas; ATMP; lentiviruses, adenovirus, AAVs, baculovirus; recombinant proteins; desenvolvimento de bioprocessos; Cromatografia; membranas, upstream e Dowstream English version bellow Manuel Carrondo is Jubilated Full Professor of Chemical and Biochemical Engineering at the Faculty of Sciences and Technology at NOVA University of Lisbon. He has extensive management experience in the biotechnology sector and is iBET’s vice-president for Business Development. His key areas of interest include (i) Animal Cell Technology and its application for human and animal health, (ii) therapeutic and diagnostic recombinant proteins, including fusion proteins, (iii) virus-like particles and pseudo viruses as vaccination agents and viruses (retro-, adeno-, lenti-) as deliverables for gene therapy, (iv) cell therapies and stem cells and (v) cGMP pilot plant scale-up and production development of biopharmaceuticals. Professor Manuel Carrondo has been Advisory Board Member of CEVEC Pharmaceuticals, PBS Biotech, CNIC (Spanish National Center for Cardiovascular Research Carlos III), Masthercells (Manufacturing Synergies for Therapeutic Cells), Alloksys Life Sciences BV, IBMT (Fraunhofer Institute for Biomedical Engineering), Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, KGI-Keck Graduate Institute, Claremont, California and GenIbet Biopharmaceuticals, Portugal. He was also the Portuguese representative to the Working Party on Biotechnology, Nanotechnology and Converging Technologies of OECD (2014-2018) and chairman of European Society of Animal Cell Technology (ESACT) from 1997-2001, currently honorary member. Manuel Carrondo was a Visiting Professor at Carnegie-Mellon University (1981), Massachusetts Institute of Technology - MIT (1988), Gesellschaft für Biotechnologische Forschung (1989 and 1993). In 2021, he was distinguished with the Cell Culture Engineering Award by Engineering Conferences International (ECI), which recognized Manuel Carrondo’s efforts to create and develop iBET and the field of cell culture engineering in Portugal, since 1989. Manuel Carrondo is currently a SAB member of GeneCellNano Flagship Programme, Finland. He has published over 250 papers, 22 book chapters and supervised 35 PhD students.
Identificação

Identificação pessoal

Nome completo
Manuel Carrondo

Nomes de citação

  • Carrondo, Manuel

Identificadores de autor

Ciência ID
E414-0F91-13E3
ORCID iD
0000-0002-4550-4574

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Tecnologias de BioProcessamento
  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Biotecnologia Industrial

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
1991
Concluído
Chemical and Biochemical Engineering (Título de Agregado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1979
Concluído
Public Health Engineering (Doutoramento)
Imperial College London, Reino Unido
"The Influence of Zeolite Type a on the Removal of Heavy Metals in Water Treatment Processes" (TESE/DISSERTAÇÃO)
--
1976
Concluído
Public Healt Engineering (Mestrado)
Imperial College London, Reino Unido
--
1971
Concluído
Engenharia Química (Licenciatura)
Universidade do Porto Faculdade de Engenharia, Portugal
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
1995 - 2018 Professor Catedrático (Docente Universitário) Universidade Nova de Lisboa, Portugal
1987 - 1995 Professor Associado (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1979 - 1987 Professor Auxiliar (Docente Universitário) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2012/03/09 - Atual Vice-Presidente Instituto de Biologia Experimental e Tecnológica, Portugal
1997 - 2001 Chairman of the Board ESACT - European society for animal cell technology, Alemanha
ESACT - European society for animal cell technology, Alemanha

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2015 - Atual Coordenador iNOVA4Health, Portugal
2009/12/01 - Atual Advisory Board Member PBS Biotechnology, Estados Unidos
2006/05/01 - 2022/01/31 Founder and Chief Scientific Officer Genibet Pharmaceuticals, Portugal
2000 - 2018 Associate Editor Elsevier - Journal of Biotechnology, Países Baixos
2011/01/01 - 2015 Scientific Advisory Board Centro Nacional de Investigaciones Cardiovasculares Carlos III, Espanha
2008 - 2014 Advisory Board Member Max-Planck-Institut fur Dynamik komplexer technischer Systeme, Alemanha
1989/01/31 - 2012/03/08 CEO Instituto de Biologia Experimental e Tecnológica, Portugal
1999 - 2008 Executive Board Member European Federation of Biotechnology, Espanha
Projetos

Projeto

Designação Financiadores
2020 - 2025 ARDAT - Accelerating Research and Development for Advanced Therapies
Grant agreement ID: 945473
Investigador
Innovative Medicines Initiative
Em curso
2020 - 2024 PURE - Precisely Patterned Nanofibers for High Performance Bioseparations
Grant agreement ID: 899732
Investigador
EU Framework Programme for Research and Innovation Leadership in Enabling and Industrial Technologies
Em curso
2019 - 2024 CRUZIVAX - Vaccine for prevention and treatment of Trypanosoma cruzi infection
Grant agreement ID: 815418
Investigador
EU Framework Programme for Research and Innovation Societal Challenges
Em curso
2017 - 2024 THE DISCOVERIES CTR
GA: 739572
Investigador
EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation
Em curso
2021 - 2023 OPPURE - Intensified AAV purification framework
PTDC/EQU-EQU/0142/2020
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2020 - 2023 iNOVA4Health Research Unit - Advancing Precision Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
UIDB/04462/2020
UID/Multi/04462/2013
UIDB/04462/2020
Investigador responsável
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020 - 2023 ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordability
Grant agreement ID: 899670
Investigador
EU Framework Programme for Research and Innovation Leadership in Enabling and Industrial Technologies
Em curso
2020 - 2022 TRANSVAC-DS - DESIGN STUDY FOR A EUROPEAN VACCINE INFRASTRUCTURE
Grant agreement ID: 951668
Investigador
EU Framework Programme for Research and Innovation Research Infrastructures and E-Infrastructures
Em curso
2017 - 2022 TRANSVAC2 - European Vaccine Research and Development Infrastructure
Grant agreement ID: 730964
Investigador
EU Framework Programme for Research and Innovation Research Infrastructures and E-Infrastructures
Em curso
2018/12/03 - 2021/12/02 Finnee - De espectros a fórmulas
PTDC/CCI-BIO/29702/2017
Universidade do Porto, Portugal

Universidade Nova de Lisboa, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019 - 2020 Further development of a new asexual blood-stage malaria vaccine candidate
Investigador
Global Health Innovative Technology Fund
Em curso
2018 - 2020 ProMeTeus - Membrane protein integrated technologies development for drug design
Grant agreement ID: 823780
Investigador
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Em curso
2015 - 2020 DIVINE - Sustainable downstream processing of vaccines through incorporation of nanobiotechnologies: novel affinity ligands and biomimetic membranes
H2020-LEIT-BIO-2014-1-635770
Investigador responsável
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2014/12/01 - 2018/05/31 CARDIOSTEM: Tecidos cardíacos e terapias baseadas em células estaminais para aplicações cardiovasculares
MITP-TB/ECE/0013/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/05/01 - 2017/04/30 Identificação de novos bioterapêuticos e desenvolvimento de sistemas de expressão
ERA-IB-2/0007/2013
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012 - 2016 BRAINVECTORS— From Brain Gene Transfer Towards Gene Therapy: Pharmacological Assessment of AAV, CAV and LVV
FP7-PEOPLE-2011-IAPP
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2012 - 2016 SADEL - Development and production of new, high-affinity protein scaffolds for therapeutic use
FP7-HEALTH-2011-Cooperation-278042
FP7-HEALTH-2011-Cooperation-278042
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2013/07/01 - 2015/12/31 Aplicação de biotecnologia de sistemas na optimização da produção de biofármacos em culturas de células animais
PTDC/BBB-BSS/0518/2012
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/07/01 - 2015/12/31 Estratégias integradas para decifrar o receptoma de células estaminais cardiacas humanas e o seu papel no processo de regeneração cardíaca
PTDC/BBB-BIO/1414/2012
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/03/21 - 2015/09/19 Desenvolvimento de anticorpos com função de bloqueio pela tecnologia de Phage Display: Inibição da via de sinalização Notch1 pelo anticorpo anti-jagged1.
PTDC/SAU-ONC/121670/2010
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2015 ComplexINC - New Technologies and Production Tools for Complex Protein Biologics.
Grant agreement ID: 279039
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2010 - 2015 CAREMI - Cardio Repair European Multidisciplinary Initiative
Grant agreement ID: 242038
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2011/07/01 - 2014/12/31 Desenvolvimento e manipulação de células estaminais usando a tecnologia de transferência génica mediada por nanopartículas para aplicação clínica de células modificadas geneticamente.
ENMED/0001/2010
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/03/01 - 2013/08/31 Melhoramento do potencial de particulas idênticas a retrovirus como vacinas para Hepatite C
PTDC/EBB-BIO/102649/2008
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/03/01 - 2013/02/28 BACULOME-Optimização de bioprocessos baseada na manipulação do estado energético celular: modelação metabólica para produção eficiente de vacinas.
PTDC/EBB-EBI/103359/2008
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2013 BRAINCAV - Nonhuman adenovirus vectors for gene transfer to the brain
Grant agreement ID: 222992
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2009 - 2012 HYPERLAB - High Yield and Performance Stem Cell Lab
Grant agreement ID: 223011
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2009 - 2011 Global HIV Vaccine Criorepository
GHRC
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
Bill and Melinda Gates Foundation
Concluído
2006 - 2011 CLINIGENE - European Network for the Advancement of Clinical Gene Transfer and Therapy
Grant Agreement: 18933
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2007/10/01 - 2010/09/30 Purificação de vírus com envelope: racionalização e aplicação de fundamentos teóricos visando a integração de processos
PTDC/EQU-EQU/71645/2006
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2010 BACULOGENES - Use of Baculovirus as a Vector for Gene Therapy
Grant agreement ID: 37541
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2006 - 2009 VITROCELLOMICS - Reducing Animal Experimentation in Preclinical Predictive Drug Testing by Human Hepatic In Vitro Models Derived from Embyonic Stem Cells
Grant agreement ID: 18940
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2005 - 2009 EPIGENEVAC - Epidemiology and New Generation Vaccines for Ehrlichia and Anaplasma Infections of Ruminants,
Grant agreement ID: 3713
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2005 - 2009 RP/PPR MARKVAC - Development of Marker Vaccines, Companion Diagnostic Tests and Improvement of Epidemiological Knowledge to Facilitate Control of Rinderpest and Peste des Petits Ruminants Viruses
Grant agreement ID: 3670
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2005/05/01 - 2008/06/30 THERAVECT - Production, purification and storage of retroviral vectors produced by modular master producer cells: focus on CoIVII vectors for the Epidermolysis Bullosa therapy
POCI/V.5/A0003/2005
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/05/01 - 2008/03/31 Cell Cryothera
POCI/V.5/A0006/2005
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2004 - 2008 CellPROM - Cell Programming by Nanoscaled Devices
Grant agreement ID: 500039
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2005/06/01 - 2007/12/31 Automação Avançada de Processos Biológicos Baseada em Sistemas Híbridos do Tipo Caixa Cinzenta
POCI/BIO/56571/2004
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/06/01 - 2007/12/31 Controlo avançado de culturas de BHK baseado em fluxos metabólicos intracelulares
POCI/BIO/57927/2004
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/05/01 - 2007/12/31 Genética, Estequiometria e Cinética do Empacotamento Múltiplo de Proteínas da Partícula Idêntica a Rotavírus
POCI/BIO/55975/2004
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2002 - 2006 RotaSafe - Novel strategies for a safe rotavirus vaccine
Grant agreement ID: QLK2-CT-2002-01249
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2002 - 2005 INSERTAGENE - Integrated strategy for efficient therapeutic retrovirus production based on modular cell lines
Grant agreement ID: QLK3-CT-2002-01949
Investigador responsável
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
2000 - 2004 RP/PPR ORALVAC - Control of rinderpest (rp) and peste des petits ruminants (ppr) infections: development of oral vaccine, role of wildlife in the maintenance of these diseases
Grant agreement ID: ICA4-CT-2000-30027
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission
Concluído
Produções

Publicações

Artigo em conferência
  1. Teixeira, A.; Alves, C.; Alves, P.M.; Carrondo, M.J.T.; Oliveira, R.. "Hybrid metabolic flux analysis/artificial neural network modeling of bioprocesses". 2005.
    10.1109/ICHIS.2005.59
  2. Rebored, F.; Carrondo, M.J.T.; Ganho, R.M.B.; Oliviera, J.F.S.. "USE OF A RAPID FLAMELESS ATOMIC ABSORPTION METHOD FOR THE DETERMINATION OF THE CONTENT OF SEDIMENTS IN THE TEJO ESTUARY, PORTUGAL.". 1981.
Artigo em revista
  1. Mooij, Petra; Mortier, Daniella; Aartse, Aafke; Murad, Alexandre B.; Correia, Ricardo; Roldão, António; Alves, Paula M.; et al. "Vaccine-induced neutralizing antibody responses to seasonal influenza virus H1N1 strains are not enhanced during subsequent pandemic H1N1 infection". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1256094.
    10.3389/fimmu.2023.1256094
  2. Murad, Alexandre B.; Sousa, Marcos Q.; Correia, Ricardo; Isidro, Inês A.; Carrondo, Manuel J. T.; Roldão, António. "Targeted Metabolic Analysis and MFA of Insect Cells Expressing Influenza HA-VLP". Processes 10 11 (2022): 2283. http://dx.doi.org/10.3390/pr10112283.
    10.3390/pr10112283
  3. Chevrel, Anne; Candela, Leo; Innocenti, Elisa; Golibrzuch, Carolin; Skudas, Romas; Schwämmle, Achim; Carrondo, Manuel J. T.; et al. "Development of versatile affinity-based system for one step purification process: Case of Group A Streptococcus vaccine". Biotechnology and Bioengineering 119 11 (2022): 3210-3220. http://dx.doi.org/10.1002/bit.28199.
    10.1002/bit.28199
  4. Mendes, João P.; Bergman, Magnus; Solbrand, Anita; Peixoto, Cristina; Carrondo, Manuel J. T.; Silva, Ricardo J. S.; João P. Mendes; et al. "Continuous Affinity Purification of Adeno-Associated Virus Using Periodic Counter-Current Chromatography". Pharmaceutics 14 7 (2022): 1346. http://dx.doi.org/10.3390/pharmaceutics14071346.
    10.3390/pharmaceutics14071346
  5. Carvalho, Sofia B.; Silva, Ricardo J. S.; Sousa, Marcos F. Q.; Peixoto, Cristina; Roldão, António; Carrondo, Manuel J. T.; Alves, Paula M.. "Bioanalytics for Influenza Virus-Like Particle Characterization and Process Monitoring". Frontiers in Bioengineering and Biotechnology 10 (2022): http://dx.doi.org/10.3389/fbioe.2022.805176.
    10.3389/fbioe.2022.805176
  6. Moreira, A.S.; Faria, T.Q.; Oliveira, J.G.; Kavara, A.; Schofield, M.; Sanderson, T.; Collins, M.; et al. "Enhancing the purification of Lentiviral vectors for clinical applications". Separation and Purification Technology 274 (2021): 118598. http://dx.doi.org/10.1016/j.seppur.2021.118598.
    10.1016/j.seppur.2021.118598
  7. João P. Mendes; Ricardo J. S. Silva; Mikael Berg; Linda Mathiasson; Cristina Peixoto; Paula M. Alves; Manuel J. T. Carrondo; et al. "Oncolytic virus purification with periodic counter-current chromatography". Biotechnology and Bioengineering 118 9 (2021): 3522-3532. https://doi.org/10.1002/bit.27779.
    10.1002/bit.27779
  8. Bárbara Fernandes; Ricardo Correia; Marcos Sousa; Manuel J. T. Carrondo; Paula M. Alves; António Roldão; Fernandes, Bárbara; et al. "Integrating high cell density cultures with adapted laboratory evolution for improved Gag-HA virus-like particles production in stable insect cell lines". Biotechnology and Bioengineering 118 7 (2021): 2536-2547. https://doi.org/10.1002/bit.27766.
    10.1002/bit.27766
  9. Correia, Ricardo; Meneses, Liane; Richheimer, Carolina; Alves, Paula M.; Carrondo, Manuel J.T.; Duarte, Ana Rita C.; Paiva, Alexandre; Roldão, António. "Improved storage of influenza HA-VLPs using a trehalose-glycerol natural deep eutectic solvent system". Vaccine 39 24 (2021): 3279-3286. http://dx.doi.org/10.1016/j.vaccine.2021.04.033.
    10.1016/j.vaccine.2021.04.033
  10. B. Carvalho, Sofia; Peixoto, Cristina; T. Carrondo, Manuel J.; S. Silva, Ricardo J.. "Downstream processing for influenza vaccines and candidates: An update". Biotechnology and Bioengineering 118 8 (2021): 2845-2869. http://dx.doi.org/10.1002/bit.27803.
    10.1002/bit.27803
  11. Moleirinho, Mafalda G.; Feast, Sean; Moreira, Ana S.; Silva, Ricardo J.S.; Alves, Paula M.; Carrondo, Manuel J.T.; Huber, Tim; Fee, Conan; Peixoto, Cristina. "3D-printed ordered bed structures for chromatographic purification of enveloped and non-enveloped viral particles". Separation and Purification Technology 254 (2021): 117681. http://dx.doi.org/10.1016/j.seppur.2020.117681.
    10.1016/j.seppur.2020.117681
  12. Moreira, Ana Sofia; Cavaco, David Guia; Faria, Tiago Q.; Alves, Paula M.; Carrondo, Manuel J. T.; Peixoto, Cristina. "Advances in Lentivirus Purification". Biotechnology Journal 16 1 (2020): 2000019. http://dx.doi.org/10.1002/biot.202000019.
    10.1002/biot.202000019
  13. Correia, Ricardo; Fernandes, Bárbara; Alves, Paula M.; Carrondo, Manuel J.T.; Roldão, António. "Improving Influenza HA-Vlps Production in Insect High Five Cells via Adaptive Laboratory Evolution". Vaccines 8 4 (2020): 589. http://dx.doi.org/10.3390/vaccines8040589.
    10.3390/vaccines8040589
  14. Moleirinho, Mafalda G.; Fernandes, Rita P.; Carvalho, Sofia B.; Bezemer, Sandra; Detmers, Frank; Hermans, Pim; Silva, Ricardo J.S.; et al. "Baculovirus affinity removal in viral-based bioprocesses". Separation and Purification Technology 241 (2020): 116693. http://dx.doi.org/10.1016/j.seppur.2020.116693.
    10.1016/j.seppur.2020.116693
  15. Vasconcelos e Sá, João; Simão, Daniel; Terrasso, Ana P.; Silva, Marta M.; Brito, Catarina; Isidro, Inês A.; Alves, Paula M.; Carrondo, Manuel J. T.. "Unveiling dynamic metabolic signatures in human induced pluripotent and neural stem cells". PLOS Computational Biology 16 4 (2020): e1007780. http://dx.doi.org/10.1371/journal.pcbi.1007780.
    10.1371/journal.pcbi.1007780
  16. Moreira, Ana Sofia; Silva, Ana Carina; Sousa, Marcos F. Q.; Hagner-McWhirterc, Åsa; Ahlénc, Gustaf; Lundgren, Mats; Coroadinha, Ana S.; et al. "Establishing Suspension Cell Cultures for Improved Manufacturing of Oncolytic Adenovirus". Biotechnology Journal 15 4 (2020): 1900411. http://dx.doi.org/10.1002/biot.201900411.
    10.1002/biot.201900411
  17. Silva, Ricardo J. S.; Moleirinho, Mafalda G.; Moreira, Ana S.; Xenopoulos, Alex; Alves, Paula M.; Carrondo, Manuel J. T.; Peixoto, Cristina. "A Flow-Through Chromatographic Strategy for Hepatitis C Virus-Like Particles Purification". Processes 8 1 (2020): 85. http://dx.doi.org/10.3390/pr8010085.
    10.3390/pr8010085
  18. Fernandes, Bárbara; Vidigal, João; Correia, Ricardo; Carrondo, Manuel J.T.; Alves, Paula M.; Teixeira, Ana P.; Roldão, António. "Adaptive laboratory evolution of stable insect cell lines for improved HIV-Gag VLPs production". Journal of Biotechnology 307 (2020): 139-147. http://dx.doi.org/10.1016/j.jbiotec.2019.10.004.
    10.1016/j.jbiotec.2019.10.004
  19. Tomás, Hélio A.; Mestre, Daniel A.; Rodrigues, Ana F.; Guerreiro, Miguel R.; Carrondo, Manuel J.T.; Coroadinha, Ana Sofia. "Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes". Molecular Therapy - Methods & Clinical Development 15 (2019): 1-8. http://dx.doi.org/10.1016/j.omtm.2019.08.001.
    10.1016/j.omtm.2019.08.001
  20. Moleirinho, Mafalda G.; Silva, Ricardo J.S.; Alves, Paula M.; Carrondo, Manuel J. T.; Peixoto, Cristina. "Current challenges in biotherapeutic particles manufacturing". Expert Opinion on Biological Therapy 20 5 (2019): 451-465. http://dx.doi.org/10.1080/14712598.2020.1693541.
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  201. De Fátima Silva Lopes, M.; Leitão, A.L.; Figueiredo Marques, J.J.; Teixeira Carrondo, M.J.; Barreto Crespo, M.T.. "Processing of extracellular lipase of Lactobacillus plantarum: Involvement of a metalloprotease". FEMS Microbiology Letters 176 2 (1999): 483-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344299243&partnerID=MN8TOARS.
    10.1016/S0378-1097(99)00276-1
  202. Cruz, P.E.; Peixoto, C.C.; Moreira, J.L.; Carrondo, M.J.T.. "Production and quality analysis of Pr55gag particles produced in baculovirus-infected insect cells". Journal of Chemical Technology and Biotechnology 72 2 (1998): 149-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032102575&partnerID=MN8TOARS.
  203. Cruz, P.E.; Cunha, A.; Peixoto, C.C.; Clemente, J.; Moreira, J.L.; Carrondo, M.J.T.. "Optimization of the production of virus-like particles in insect cells". Biotechnology and Bioengineering 60 4 (1998): 408-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032553513&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0290(19981120)60:4<408::AID-BIT2>3.0.CO;2-Q
  204. Cruz, H.J.; Moreira, J.L.; Stacey, G.; Dias, E.M.; Hayes, K.; Looby, D.; Griffiths, B.; Carrondo, M.J.T.. "Adaptation of BHK cells producing a recombinant protein to serum-free media and protein-free medium". Cytotechnology 26 1 (1998): 59-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031910446&partnerID=MN8TOARS.
    10.1023/A:1007951813755
  205. Cruz, P.E.; Moreira, J.L.; Carrondo, M.J.T.. "Insect cell growth evaluation during serum-free adaptation in stirred suspension cultures". Biotechnology Techniques 11 2 (1997): 117-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030890382&partnerID=MN8TOARS.
  206. Almeida, J.S.; Reis, M.A.M.; Carrondo, M.J.T.. "A unifying kinetic model of denitrification". Journal of Theoretical Biology 186 2 (1997): 241-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031582387&partnerID=MN8TOARS.
    10.1006/jtbi.1996.0352
  207. Xavier, A.M.R.B.; Crespo, J.P.S.G.; Carrondo, M.J.T.. "Effect of cell purge on the stability of microfiltration cell recycle fermentation systems". Journal of Chemical Technology and Biotechnology 69 2 (1997): 203-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030616089&partnerID=MN8TOARS.
    10.1002/(SICI)1097-4660(199706)69:2<203::AID-JCTB708>3.0.CO;2-X
  208. Cruz, H.J.; Dias, E.M.; Moreira, J.L.; Carrondo, M.J.T.. "Cell-dislodging methods under serum-free conditions". Applied Microbiology and Biotechnology 47 5 (1997): 482-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030990534&partnerID=MN8TOARS.
    10.1007/s002530050960
  209. Coelhoso, I.M.; Crespo, J.P.S.G.; Carrondo, M.J.T.. "Kinetics of liquid membrane extraction in systems with variable distribution coefficient". Journal of Membrane Science 127 2 (1997): 141-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030615762&partnerID=MN8TOARS.
    10.1016/S0376-7388(96)00257-8
  210. Gonçalves, L.M.D.; Ramos, A.; Almeida, J.S.; Xavier, A.M.R.B.; Carrondo, M.J.T.. "Elucidation of the mechanism of lactic acid growth inhibition and production in batch cultures of Lactobacillus rhamnosus". Applied Microbiology and Biotechnology 48 3 (1997): 346-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030953411&partnerID=MN8TOARS.
    10.1007/s002530051060
  211. Coelhoso, I.M.; Silvestre, P.; Viegas, R.M.C.; Crespo, J.P.S.G.; Carrondo, M.J.T.. "Membrane-based solvent extraction and stripping of lactate in hollow-fibre contactors". Journal of Membrane Science 134 1 (1997): 19-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342276131&partnerID=MN8TOARS.
    10.1016/S0376-7388(97)00081-1
  212. Cardoso, M.M.; Barradas, M.J.; Carrondo, M.T.; Kroner, K.H.; Crespo, J.G.. "Mechanisms of amino acid partitioning in cationic reversed micelles". Bioseparation 7 2 (1997): 65-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031389452&partnerID=MN8TOARS.
    10.1023/A:1008080215915
  213. Coelhoso, I.M.; Crespo, J.P.S.G.; Carrondo, M.J.T.. "Modeling of ion-pairing extraction with quaternary amines". Separation Science and Technology 31 4 (1996): 491-511. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030085788&partnerID=MN8TOARS.
  214. Alves, P.M.; Flögel, U.; Brand, A.; Leihfritz, D.; Carrondo, M.J.T.; Santos, H.; Sonnewald, U.. "Immobilization of primary astrocytes and neurons for on-line monitoring of biochemical processes by nmr". Developmental Neuroscience 18 5-6 (1996): 478-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029850062&partnerID=MN8TOARS.
    10.1159/000111443
  215. Pereira, H.; Lemos, P.C.; Reis, M.A.M.; Crespo, J.P.S.G.; Carrondo, M.J.T.; Santos, H.. "Model for carbon metabolism in biological phosphorus removal processes based on in vivo13C-NMR labelling experiments". Water Research 30 9 (1996): 2128-2138. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030247223&partnerID=MN8TOARS.
    10.1016/0043-1354(96)00035-8
  216. Alves, P.M.; Moreira, J.L.; Rodrigues, J.M.; Aunins, J.G.; Carrondo, M.J.T.. "Two-dimensional versus three-dimensional culture systems: Effects on growth and productivity of BHK cells". Biotechnology and Bioengineering 52 3 (1996): 429-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030571271&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0290(19961105)52:3<429::AID-BIT9>3.0.CO;2-M
  217. Almeida, J.S.; Julio, S.M.; Reis, M.A.M.; Carrondo, M.J.T.. "Nitrite inhibition of denitrification by Pseudomonas fluorescens". Biotechnology and Bioengineering 46 3 (1995): 194-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029636427&partnerID=MN8TOARS.
  218. Moreira, J.L.; Alves, P.M.; Aunins, J.G.; Carrondo, M.J.T.. "Hydrodynamic effects on BHK cells grown as suspended natural aggregates". Biotechnology and Bioengineering 46 4 (1995): 351-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029294174&partnerID=MN8TOARS.
  219. Moreira, J.L.; Santana, P.C.; Feliciano, A.S.; Cruz, P.E.; Racher, A.J.; Griffiths, J.B.; Carrondo, M.J.T.. "Effect of Viscosity upon Hydrodynamically Controlled Natural Aggregates of Animal Cells Grown in Stirred Vessels". Biotechnology Progress 11 5 (1995): 575-583. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029360524&partnerID=MN8TOARS.
    10.1021/bp00035a012
  220. Almeida, J.S.; Reis, M.A.M.; Carrondo, M.J.T.. "Competition between nitrate and nitrite reduction in denitrification by Pseudomonas fluorescens". Biotechnology and Bioengineering 46 5 (1995): 476-484. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029636515&partnerID=MN8TOARS.
  221. Moreira, J.L.; Cruz, P.E.; Santana, P.C.; Feliciano, A.S.; Lehmann, J.; Carrondo, M.J.T.. "Influence of power input and aeration method on mass transfer in a laboratory animal cell culture vessel". Journal of Chemical Technology and Biotechnology 62 2 (1995): 118-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029239545&partnerID=MN8TOARS.
    10.1002/jctb.280620203
  222. Moreira, JosL.; Cruz, P.E.; Santana, P.C.; Aunins, J.G.; Carrondo, M.J.T.. "Formation and disruption of animal cell aggregates in stirred vessels: Mechanisms and kinetic studies". Chemical Engineering Science 50 17 (1995): 2747-2764. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029360675&partnerID=MN8TOARS.
    10.1016/0009-2509(95)00118-O
  223. Moreira, J.L.; Alves, P.M.; Feliciano, A.S.; Aunins, J.G.; Carrondo, M.J.T.. "Serum-free and serum-containing media for growth of suspended BHK aggregates in stirred vessels". Enzyme and Microbial Technology 17 5 (1995): 437-444. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029006055&partnerID=MN8TOARS.
    10.1016/0141-0229(94)00071-X
  224. Xavier, A.M.R.B.; Goncalves, L.M.D.; Moreira, J.L.; Carrondo, M.J.T.. "Operational patterns affecting lactic acid production in ultrafiltration cell recycle bioreactor". Biotechnology and Bioengineering 45 4 (1995): 320-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029239546&partnerID=MN8TOARS.
    10.1002/bit.260450406
  225. Coelhoso, I.M.; Moura, T.F.; Crespo, J.P.S.G.; Carrondo, M.J.T.. "Transport mechanisms in liquid membranes with ion exchange carriers". Journal of Membrane Science 108 3 (1995): 231-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029614787&partnerID=MN8TOARS.
    10.1016/0376-7388(95)00174-3
  226. Racher, A.J.; Moreira, J.L.; Alves, P.M.; Wirth, M.; Weidle, U.H.; Hauser, H.; Carrondo, M.J.T.; Griffiths, J.B.. "Expression of recombinant antibody and secreted alkaline phosphatase in mammalian cells. Influence of cell line and culture system upon production kinetics". Applied Microbiology and Biotechnology 40 6 (1994): 851-856. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028258803&partnerID=MN8TOARS.
    10.1007/BF00173987
  227. Crespo, M.T.B.; Carrondo, M.J.T.. "Influence of operational parameters in the flocculation and production of Lactobacillus plantarum". Journal of Industrial Microbiology 13 1 (1994): 63-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028344385&partnerID=MN8TOARS.
  228. Moreira, J.L.; Alves, P.M.; Aunins, J.G.; Corrondo, M.J.T.. "Changes in animal cell natural aggregates in suspended batch cultures". Applied Microbiology and Biotechnology 41 2 (1994): 203-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028285572&partnerID=MN8TOARS.
    10.1007/BF00186960
  229. Moreira, J.L.; Feliciano, A.S.; Santana, P.C.; Cruz, P.E.; Aunins, J.G.; Carrondo, M.J.T.. "Repeated-batch cultures of Baby Hamster Kidney cell aggregates in stirred vessels". Cytotechnology 15 1-3 (1994): 337-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028708644&partnerID=MN8TOARS.
    10.1007/BF00762409
  230. Partidário, P.J.; Carrondo, M.J.T.. "Mass transfer and reaction of trimethylamine in a three-phase biological reactor". Journal of Chemical Technology & Biotechnology 57 4 (1993): 299-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027304751&partnerID=MN8TOARS.
    10.1002/jctb.280570402
  231. Reis, M.A.M.; Almeida, J.S.; Lemos, P.C.; Carrondo, M.J.T.. "Effect of hydrogen sulfide on growth of sulfate reducing bacteria". Biotechnology and Bioengineering 40 5 (1992): 593-600. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026911046&partnerID=MN8TOARS.
  232. Crespo, J.P.S.G.; Xavier, A.M.R.B.; Barreto, M.T.O.; Gonçalves, L.M.D.; Almeida, J.S.; Carrondo, M.J.T.. "Tangential flow filtration for continuous cell recycle culture of acidogenic bacteria". Chemical Engineering Science 47 1 (1992): 205-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026617133&partnerID=MN8TOARS.
    10.1016/0009-2509(92)80214-W
  233. Gonçalves, L.M.D.; Barreto, M.T.O.; Xavier, A.M.B.R.; Carrondo, M.J.T.; Klein, J.. "Inert supports for lactic acid fermentation -a technological assessment". Applied Microbiology and Biotechnology 38 3 (1992): 305-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026437841&partnerID=MN8TOARS.
    10.1007/BF00170077
  234. Barreto, M.T.O.; Melo, E.P.; Almeida, J.S.; Xavier, A.M.R.B.; Carrondo, M.J.T.. "A kinetic method for calculating the viability of lactic starter cultures". Applied Microbiology and Biotechnology 34 5 (1991): 648-652. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026029083&partnerID=MN8TOARS.
    10.1007/BF00167916
  235. Barreto, M.T.O.; Melo, E.P.; Moreira, J.L.; Carrondo, M.J.T.. "High cell density reactor for the production of Lactobacillus plantarum". Journal of Industrial Microbiology 7 1 (1991): 63-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025962387&partnerID=MN8TOARS.
    10.1007/BF01575605
  236. Gonçalves, L.M.D.; Xavier, A.M.R.B.; Almeida, J.S.; Carrondo, M.J.T.. "Concomitant substrate and product inhibition kinetics in lactic acid production". Enzyme and Microbial Technology 13 4 (1991): 314-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026136571&partnerID=MN8TOARS.
    10.1016/0141-0229(91)90150-9
  237. Crespo, J.P.S.G.; Moura, M.J.; Almeida, J.S.; Carrondo, M.J.T.. "Ultrafiltration membrane cell recycle for continuous culture of Propionibacterium". Journal of Membrane Science 61 C (1991): 303-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026219271&partnerID=MN8TOARS.
    10.1016/0376-7388(91)80023-Y
  238. Reis, M.A.M.; Lemos, P.C.; Martins, M.J.; Costa, P.C.; Gonçalves, L.M.D.; Carrondo, M.J.T.. "Influence of sulfates and operational parameters on volatile fatty acids concentration profile in acidogenic phase". Bioprocess Engineering 6 4 (1991): 145-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025963769&partnerID=MN8TOARS.
    10.1007/BF00369251
  239. Crespo, J.P.S.G.; Moura, M.J.; Carrondo, M.J.T.. "Some engineering parameters for Propionic acid fermentation coupled with Ultrafiltration". Applied Biochemistry and Biotechnology 24-25 1 (1990): 613-625. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025029730&partnerID=MN8TOARS.
    10.1007/BF02920283
  240. Reis, M.A.M.; Lemos, P.C.; Almeida, J.S.; Carrondo, M.J.T.. "Influence of produced acetic acid on growth of sulfate reducing bacteria". Biotechnology Letters 12 2 (1990): 145-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025215258&partnerID=MN8TOARS.
    10.1007/BF01022432
  241. Crespo, J.P.S.G.; Almeida, J.S.; Moura, M.J.; Carrondo, M.J.T.. "Modeling of immobilized cell reactor for propionic acid fermentation". Biotechnology and Bioengineering 36 7 (1990): 705-716. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025701083&partnerID=MN8TOARS.
  242. Bartolomeu, F.; Chambino, T.; Carrondo, M.J.T.. "Applicability of filtration tests for extreme industrial sludges". Filtration and Separation 26 4 (1989): 288-291. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024694739&partnerID=MN8TOARS.
  243. Matos, H.A.; De Azevedo, E.G.; Simoes, P.C.; Carrondo, M.T.; Da Ponte, M.N.. "Phase equilibria of natural flavours and supercritical solvents". Fluid Phase Equilibria 52 C (1989): 357-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024924653&partnerID=MN8TOARS.
    10.1016/0378-3812(89)80341-3
  244. Barreto, M.T.O.; Melo, E.P.; Carrondo, M.J.T.. "Starter culture production in fluidized bed reactor with a flocculent strain of L. plantarum". Biotechnology Letters 11 5 (1989): 337-342. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249974624&partnerID=MN8TOARS.
    10.1007/BF01024514
  245. Reis, M.A.M.; Goncalves, L.M.D.; Carrondo, M.J.T.. "Sulphate removal in acidogenic phase anaerobic digestion". Environmental Technology Letters 9 8 (1988): 775-784. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023683211&partnerID=MN8TOARS.
  246. Reis, M.A.M.; Goncalves, L.M.D.; Carrondo, M.J.T.. "Sulfate reduction in acidogenic phase anaerobic digestion". Water Science and Technology 20 11-12 (1988): 345-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024217388&partnerID=MN8TOARS.
  247. Carrondo, M.J.T.; Crespo, J.P.S.G.; Moura, M.J.. "Production of propionic acid using a xylose utilizing Propionibacterium". Applied Biochemistry and Biotechnology 17 1-3 (1988): 295-312. http://www.scopus.com/inward/record.url?eid=2-s2.0-51249176725&partnerID=MN8TOARS.
    10.1007/BF02779164
  248. Carrondo, Manuel J.T.; Ascensao M. Reis, M.. "FIXED FILM ANAEROBIC DIGESTION.". Global Bioconvers (1987): 101-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023562859&partnerID=MN8TOARS.
  249. Carrondo, M.J.T.; Reboredo, F.; Ganho, R.M.B.; Oliveira, J.F.S.. "Analysis of sediments for heavy metals by a rapid electrothermal atomic-absorption procedure". Talanta 31 7 (1984): 561-564. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021612079&partnerID=MN8TOARS.
    10.1016/0039-9140(84)80141-1
  250. Carrondo, M.J.T.; Lester, J.N.; Perry, R.; Carrondo, Manuel J.T.; Perry, Roger; Lester, John N.. "Sedimentation of zeolite type A in water and wastewater". Effluent & Water Treatment Journal 23 7 (1983): 271-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020789758&partnerID=MN8TOARS.
  251. Carrondo, M.J.T.; Silva, J.M.C.; Figueira, M.I.I.. "Anaerobic filter treatment of molasses fermentation wastewater". Water Science and Technology 15 8-9 (1983): 117-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021036784&partnerID=MN8TOARS.
  252. Campbell, J.R.; Luthy, R.G.; Carrondo, M.J.T.. "Measurement and Prediction of Distribution Coefficients for Wastewater Aromatic Solutes". Environmental Science and Technology 17 10 (1983): 582-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020841555&partnerID=MN8TOARS.
    10.1021/es00116a005
  253. Carrondo, M.J.T.; Lester, J.N.; Perry, R.. "Type A zeolite in the activated sludge process - II: Heavy metal removal". Journal of the Water Pollution Control Federation 53 3 I (1981): 344-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019800698&partnerID=MN8TOARS.
  254. Obeng, L.A.; Carrondo, M.J.T.; Perry, R.; Lester, J.N.. "The influence of zeolite type A on metal concentrations in water and waste water". Journal of the American Oil Chemists' Society 58 1 (1981): 81-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-51249185991&partnerID=MN8TOARS.
    10.1007/BF02666060
  255. Carrondo, M.J.T.; Perry, R.; Lester, J.N.. "Type A zeolite in the activated sludge processes - I: Treatment parameters". Journal of the Water Pollution Control Federation 52 11 (1980): 2796-2806. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019119850&partnerID=MN8TOARS.
  256. Carrondo, M.J.T.; Perry, R.; Lester, J.N.. "Comparison of electrothermal atomic absorption spectrometry of the metal content of sewage sludge with flame atomic absorption spectrometry in conjunction with different pretreatment methods". Analytica Chimica Acta 106 2 (1979): 309-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000598730&partnerID=MN8TOARS.
    10.1016/S0003-2670(01)85014-5
  257. Carrondo, M.J.T.; Lester, J.N.; Perry, R.. "Electrothermal atomic absorption determination of total aluminium (including zeolite type a) in waters and waste waters". Analytica Chimica Acta 111 C (1979): 291-295. http://www.scopus.com/inward/record.url?eid=2-s2.0-0018562541&partnerID=MN8TOARS.
    10.1016/S0003-2670(01)93274-X
  258. Carrondo, M.J.T.; Perry, R.; Lester, J.N.. "Influence of conditioning agents on the determination of metallic content of sewage sludge by atomic-absorption spectrophotometry with electrothermal atomisation". Analyst 104 1243 (1979): 937-943. http://www.scopus.com/inward/record.url?eid=2-s2.0-0018571069&partnerID=MN8TOARS.
  259. Carrondo, M.J.T.; Lester, J.N.; Perry, R.. "Determination of aluminium, calcium, iron and magnesium in sewages and sewage effluent by a rapid electrothermal atomic-absorption spectroscopic method". Analyst 104 1242 (1979): 831-836. http://www.scopus.com/inward/record.url?eid=2-s2.0-0018611154&partnerID=MN8TOARS.
  260. Carrondo, M.J.T.; Perry, R.; Lester, J.N.. "Comparison of a rapid flameless atomic absorption procedure for the analysis of the metallic content of sewages and sewage effluents with flame atomic absorption methods". Science of the Total Environment, The 12 1 (1979): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0018393949&partnerID=MN8TOARS.
    10.1016/0048-9697(79)90002-0
  261. Carrondo, M.J.T.; Lester, J.N.; Perry, R.. "An investigation of a flameless atomic-absorption method for determination of aluminium, calcium, iron and magnesium in sewage sludge". Talanta 26 10 (1979): 929-933. http://www.scopus.com/inward/record.url?eid=2-s2.0-0018672848&partnerID=MN8TOARS.
    10.1016/0039-9140(79)80128-9
Capítulo de livro
  1. Silva, Ricardo J. S.; Mendes, João P.; Carrondo, Manuel J. T.; Marques, Paula M.; Peixoto, Cristina. "Continuous Chromatography Purification of Virus-Based Biopharmaceuticals: A Shortcut Design Method". In Methods in Molecular Biology, 367-384. Springer US, 2019.
    10.1007/978-1-0716-0191-4_21
  2. Inês A Isidro; Daniel AM Pais; Paula Alves; Carrondo, Manuel; Teixeira, A.P.; Oliveira, R.; Alves, P.M.; Carrondo, M.J.T.. "Online Control Strategies". In Comprehensive Biotechnology, 943-951. Países Baixos: Elsevier - ScienceDirect, 2019.
    Publicado • 10.1016/B978-0-08-088504-9.00143-4
  3. Sá, João V.; Duarte, Tiago M.; Carrondo, Manuel J. T.; Alves, Paula M.; Teixeira, Ana P.. "Metabolic Flux Analysis: A Powerful Tool in Animal Cell Culture". In Animal Cell Culture, 521-539. Springer International Publishing, 2014.
    10.1007/978-3-319-10320-4_16
Livro
  1. Fernandes, F.; Teixeira, A.P.; Carinhas, N.; Carrondo, M.J.T.; Alves, P.M.. Production of complex virus-like particles in insect cells. 2014.
    10.2217/FMEB2013.13.67
  2. Roldão, A.; Cox, M.; Alves, P.; Carrondo, M.; Vicente, T.. Industrial Large Scale of Suspension Culture of Insect Cells. 2014.
    10.1002/9783527683321.ch10
  3. Roldão, A.; Silva, A.C.; Mellado, M.C.M.; Alves, P.M.; Carrondo, M.J.T.. Viruses and Virus-Like Particles in Biotechnology: Fundamentals and Applications. 2011.
    10.1016/B978-0-08-088504-9.00072-6
  4. Vicente, T.; Peixoto, C.; Carrondo, M.J.T.; Alves, P.M.. Virus production for clinical gene therapy. 2009.
    10.1007/978-1-59745-561-9_24
  5. Teixeira, A.; Alves, C.M.L.; Alves, P.M.; Carrondo, M.J.T.; Oliveira, R.. Hybrid metabolic flux analysis/data-driven modelling of bioprocesses. 2006.
    10.1016/S1570-7946(06)80287-7
  6. Roldão, A.; Vieira, H.L.A.; Carrondo, M.J.T.; Alves, P.M.; Oliveira, R.. Rotavirus-like particle production: Simulation of protein production and particle assembly. 2006.
    10.1016/S1570-7946(06)80288-9
  7. Oliveira, R.; Cunha, A.; Clemente, J.; Carrondo, M.J.T.. Model-based bioreactor optimisation based on hybrid first principles/artificial neural network dynamical models. 2004.
    10.1016/S1570-7946(04)80187-1
  8. Moreira, J.L.; Alves, P.M.; Rodrigues, J.M.; Cruz, P.E.; Aunins, J.G.; Carrondo, M.J.T.. Studies of baby hamster kidney natural cell aggregation in suspended batch cultures. 1994.
Tese / Dissertação
  1. Sá, João Alberto Pacheco Marques de Vasconcelos. "Metabolic Systems Biology for Stem Cell Bioprocesses". Doutoramento, 2020. http://hdl.handle.net/10362/96830.
  2. Baptista De Carvalho, Sofia. "Downstream strategies for VLPs as candidate universal vaccine for Influenza". Doutoramento, 2018. http://hdl.handle.net/10362/93880.
  3. Nestola, Piergiuseppe. "Improving downstream processing for viral vectors and viral vaccines". Doutoramento, 2015. http://hdl.handle.net/10362/14845.
  4. Henriques, Ricardo Perdigão. "The role of the miR-200 family in the epithelial-to-mesenchymal transition (EMT)". Doutoramento, 2015. http://hdl.handle.net/10362/20499.
  5. Vicente, Tiago. "Downstream processing development of enveloped viruses for clinical applications: innovative tools for rational process optimization". Doutoramento, 2010. http://hdl.handle.net/10362/5247.
  6. Roldão, António Manuel Missionário. "Production optimization of rotavirus-like particles: a system biology approach". Doutoramento, 2010. http://hdl.handle.net/10362/5246.
  7. Carmo, Marlene. "Gammaretroviral and lentiviral vectors for gene therapy: stability and inactivation mechanisms". Doutoramento, 2009. http://hdl.handle.net/10362/5241.
  8. Ferreira, Tiago Bruno Pereira Soares. "Adenovirus as a Biopharmaceutical". Doutoramento, 2007. http://hdl.handle.net/10362/73622.
  9. Coelhoso, Isabel. "Extracção de lactato com membranas líquidas". Doutoramento, 1992. http://hdl.handle.net/10362/4459.
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2013 - 2018 Downstream strategies for VLPs as candidate universal vaccine for Influenza
Coorientador de Sofia Baptista de Carvalho
Ciências da Engenharia e Tecnologia (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005 - 2010 Production Optimization of Rotavirusl-like Particles: a Systems Biology Approach
Orientador de António Manuel Missionário Roldão
Ciências da Engenharia e Tecnologia (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003 - 2008 Bridging Systems Biology and Bioprocess Engineering Application to Mammalic Cell Cultures
Coorientador de Ana Margarida Palma Teixeira
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2002 - 2007 Development of a Vaccine Candidate Against Heartwater
Coorientador de Isabel Eloi Marcelino
Engenharia Química (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1999 - 2003 Mammalian Cell Growth Arrest for Biopharmaceutical Production Improvement
Orientador de Ana Verónica de Sousa Uva Carvalhal
Engenharia Química (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1995 - 2001 Nmr Studies of Central Metabolism in Brain: Immobilized Primary Cultures as Model Systems
Coorientador de Paula Maria Marques Leal Sanches Alves
Bioengenharia (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1994 - 1999 Global Optimization of Bioprocesses-a Focus on Complex Bioproducts
Orientador de Pedro Estilista Pereira Monteiro Cruz
Engenharia Química (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1994 - 1999 Modulation of Bhk Cell Metabolism by Nutrient Manipulation
Orientador de Hélder Joaquim Soares da Cruz
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1990 - 1994 Engenharia de Agregados de Células Animais
Orientador de José Luís da Piedade Moreira
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1985 - 1993 Tecnologia de Fermentação Láctica. Cinética e Imobilização
Orientador
Engenharia Biológica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1987 - 1992 Produção de Culturas de Arranque Lácticas em Reactores de Alta Densidade Celular
Orientador de Maria Teresa F. O. Barreto Goulão Crespo
Engenharia Biológica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1985 - 1990 Estudo do Processo de Fermentação Propiónica
Orientador de João Paulo Serejo Goulão Crespo
Engenharia Química (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Distinções

Prémio

2021 Cell Culture Engineering Award of Excelence
Engineering Conferences International, Estados Unidos
2004 Prémio de Excelência Científica
Ministério da Educação, Portugal
1988 Oeiras Municipality Gold Medal of Merit
Câmara Municipal de Oeiras, Portugal

Outra distinção

2007 ESACT - European Society for Animal Cell Technology Medal of Merit
ESACT - European society for animal cell technology, Alemanha
2005 ESACT - European Society for Animal Cell Technology - Elected Honorary Member
ESACT - European society for animal cell technology, Alemanha