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Dr Ioannis Sotiropoulos is a Reseracher C - Group leader at the Institute of Biosciences & Applications, NCSR Demokritos, Athens, Greece as well as an Affiliated Researcher at ICVS, Medical School, University of Minho. After the completion of his Bachelor degree in Biology (University of Patras, Greece), Ioannis performed his PhD studies in Neurosciences at the University of Heidelberg/Max Planck Institute of Psychiatry, Germany. He has previously worked and received training in prestigious international institutions such as RIKEN Brain Science Institute (Tokyo, Japan), University College London (London, UK), Columbia University (NY, USA), MRC Center for Synaptic plasticity (Bristol, UK), Medical School of Athens (Greece). His research work focuses on understanding the orchestrating role of lifetime, daily stress on the onset of Alzheimer´s disease (AD) with specific focus on the relationship between AD and depression, a stress-related disorder. Dr Sotiropoulos utilizes molecular, electrophysiological, cellular, structural, proteomic, epigenetic, ultrastructural and behavioural approaches on the brain analysis related to the involvement of stress-driven molecules in neuronal (mal)function, pathological brain aging and peripheral biomarkers. Ioannis has successfully raised funds as scientific coordinator of national and international, state, private and industrial projects e.g. ELIDEK (Greece), FCT (Portugal), Servier (France), Jerome Leujeune Foundation (France), NIH (USA) and European programs. His teaching activities include participation in different master programs in Greece (UNiversity fo Athens, Crete Univeristy, Thessaloniki University) as well as o Postgraduation courses at Medical School, University of Minho while he teaches in an annual basis in courses of different Greek, Portuguese and European Universities (e.g. Athens Medical School, Greece, Coimbra Medical School, Portugal). He has so far supervised 23 PhD and Master students and plethora of ERASMUS, undergraduate students from Greece, France, Portugal and other EU countries. His work is published in high esteemed journals such as PNAS, Molecular Psychiatry, EMBO, Cell Death&Diif, Aging Cell, J Neuroscience. His scientific achievements are internationally recognized in the form of prizes/awards e.g. Hirnliga Alzheimer Award 2009, European College of Neuropsychopharmacology (ECNP) Fellowship 2009 Award, Canon Foundation Award 2013, AD/PD Young Faculty 2014 Award, Jerome Lejeune 2017 Award, Janssen Innovation Award 2017. His supervising/mentoring skills are recently recognized by Alzheimer's Association as he got the Alzheimer’s Association Best Mentor Award in Neuroscience 2021. He is routinely invited to lectures at prestigious international meetings ([e.g. US Society for Neuroscience, AAIC, AD/PD conferences, EuroTau meeting., ECNP, FENS). He participates in the scientific council of different scientific organisations such as the European College of Neuropsychopharmacology (ECNP) and EuroTau consortium/conference. Ioannis is a regular reviewer for respectable journals (e.g. Mol Psychiatry, Brain, PNAS, Mol Neurodegeneration, Aging Cell, JBC) and grant evaluation panels (e.g. AAIC Alzheimer Association organisation, Alzheimer France and others).
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Identificação

Identificação pessoal

Nome completo
Ioannis Sotiropoulos

Nomes de citação

  • Sotiropoulos, Ioannis

Identificadores de autor

Ciência ID
E410-7256-DD79
ORCID iD
0000-0003-0115-0038

Endereços de correio eletrónico

  • ioannis@med.uminho.pt (Profissional)
  • ioannis@bio.demokritos.gr (Profissional)

Telefones

Telefone
  • (+30) 2106503588 (Profissional)
Telemóvel
  • 918932030 (Pessoal)

Moradas

  • Institute of Biosciences & Applications, NCSR Demokritos, 15310, Athens, Athens, Grécia (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Formação
Grau Classificação
2006/12/11
Concluído
 Neuroscience (Doctor of Philosophy)
Ruprecht Karls Universität Heidelberg, Alemanha
"Identification of the cellular mechanisms underlying the contribution of stress and glucocorticoids to Alzheimer’s disease pathology" (TESE/DISSERTAÇÃO)
 Magna cum laude
2000/04/11
Concluído
 Biology BSc (Bachelor)
Panepistemio Patron, Grécia
"Developmental study of glutamate subtype receptor in mouse cerebellum" (TESE/DISSERTAÇÃO)
 8/10
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/04/01 - 2030/12/31 Investigador Coordenador Convidado (carreira) (Investigação) Ethniko Kentro Ereunas Physikon Epistemon Demokritos, Grécia
Ethniko Kentro Ereunas Physikon Epistemon Demokritos, Grécia
2019/01/01 - 2023/12/31 Investigador principal convidado (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/01/01 - 2018/12/31 Investigador Auxiliar (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2014/01/01 - 2018/12/31 FCT Independent Investigator - Young Group Leader Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010/01/01 - 2013/12/31 Senior Post-doc researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007/01/01 - 2008/12/01 Researcher/Post-doc Rikagaku Kenkyujo, Japão
2001/01/01 - 2006/12/11 PhD student Max-Planck-Institut für Psychiatrie, Alemanha
2004/08/01 - 2005/07/31 Researcher/PhD student University College London Department of Molecular Neuroscience, Reino Unido
2000/04/15 - 2000/10/31 Research trainee Columbia University College of Physicians and Surgeons, Estados Unidos
1999/01/01 - 1999/12/31 Diploma research project for B.Sc. Panepistemio Patron Tmema Iatrikes, Grécia
Projetos

Bolsa

Designação Financiadores
2018/01/01 - 2020/12/01 GR signaling in stress-driven Alzheimer's disease pathology
FrAzheir021
Investigador responsável
Association France Alzheimer et Maladies Apparentées, França
 Association France Alzheimer et Maladies Apparentées
Em curso
2017/09/15 - 2020/03/01 Tau therapeutics in Alzheimer and Down syndrome brain pathologies
FJL-pd1
Investigador responsável
Fondation Jérôme Lejeune, França
Em curso
2014/01/01 - 2015/06/01 Tau as a key protein of synaptic physiology and brain pathology
CF-416
Investigador responsável
Canon Foundation in Europe, Países Baixos
Concluído
2011/06/01 - 2014/05/31 Mechanisms of stress-induced mood and cognitive dysfunction
PTDC/SAU-NMC/113934/2009
Investigador responsável
Fundação para a Ciência e a Tecnologia, Portugal
Concluído
2010/03/01 - 2013/12 Multimodal analysis of the neurobiology of depression
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105180/PT
 Universidade do Algarve Faculdade de Ciências e Tecnologia
2010/01/01 - 2012/12/31 Stress-driven brain aging and biomarkers
ICVS_ClGr-03
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluído
2007/01/01 - 2008/12/15 Gender-dependent stress influence on Tau pathology
PE 06069
Bolseiro de Pós-Doutoramento
Japanese Society for Promoting Science (JSPS), Japão
Concluído
2001/01/01 - 2003/12/31 identifying the role of chronic stress and GR signaling in precipitation of Alzheimer's disease
SPP 333/7 Al-1
Bolseiro de Doutoramento
Deutsche Forschungsgemeinschaft, Alemanha
Concluído

Projeto

Designação Financiadores
2016/09/01 - 2019/09/01 In vivo analysis of novel compounds against synaptic pathology in early stages of Alzheimer's disease
Servier-AMPA-PAM-0391
Investigador responsável
Les Laboratoires Servier SAS Recherche & Développement, França
Concluído

Outro

Designação Financiadores
2016/09/01 - 2019/08/31 PAUILF - Luso-France Integrated Actions “The multiple faces of stress-triggered Tau pathology: implication for Alzheimer´s disease
PAULIF-319
Orientador
PAUILF - Luso-France Integrated Actions , Portugal
Concluído
2016/10/01 - 2018/09/30 Tau as the converging protein in chronic stress and Alzheimer’s disease synaptic pathologies
Luso-Al013
Investigador responsável
CRUP-Luso-German Integrated Actions, Portugal
Concluído
2017/01/01 - 2017 Identifying the key role of Tau protein in stress-driven Alzheimer and depressive brain pathologies
JanssenPremio-Neurosc1
Investigador responsável
Janssen-Cilag Farmacêutica Lda, Portugal
Concluído
2009/07/01 - 2010/03/01 Stress role on synaptic plasticity and neurodegeneration
BC-Exch-09-17
Investigador Pós-doutorado
Britisj Council UK, Reino Unido
Concluído
2005/01/01 - 2006/12/31 Gender dimorphism in depression and in antidepressant treatment
DAAD-IKY-2004-DI94
Bolseiro de Doutoramento
DAAD-IKY, Alemanha
Concluído
2004/08/01 - 2005/07/31 Steroid action in health and disease
HPMT-GH-00-00159-06
Bolseiro de Doutoramento
Marie Curie Trainning program, Bélgica
Concluído
Produções

Publicações

Artigo em revista
  1. Patrícia Amorim Gomes; Cristian Bodo; Carlos Nogueras-Ortiz; Martina Samiotaki; Chen M; Carina Soares-Cunha; Joana Silva; et al. "A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology.". Cell communication and signaling : CCS (2023): https://europepmc.org/articles/PMC9926669.
    10.1186/s12964-023-01045-z
  2. Francisca Monteiro; Carvalho Ó; Sousa N; Silva FS; Sotiropoulos I. "Photobiomodulation and visual stimulation against cognitive decline and Alzheimer's disease pathology: A systematic review.". Alzheimer's & dementia (New York, N. Y.) (2022): https://europepmc.org/articles/PMC9695760.
    10.1002/trc2.12249
  3. Guerreiro SR; Guimarães MR; Silva JM; Dioli C; Vamvaka-Iakovou A; Sousa R; Gomes P; et al. "Chronic pain inhibits autophagy in hippocampus while the analgetic drug, Gabapentin reverts this SNI-driven action.". Molecular psychiatry (2022): https://doi.org/10.1038/s41380-022-01874-3.
    10.1038/s41380-022-01874-3
  4. Guerreiro, S; Guimarães MR; Joana Silva; Chrysoula Dioli; Vamvaka-Iakovou A; Sousa R; Patrícia Amorim Gomes; et al. "Chronic pain causes Tau-mediated hippocampal pathology and memory deficits.". Molecular psychiatry (2022): https://doi.org/10.1038/s41380-022-01707-3.
    10.1038/s41380-022-01707-3
  5. Gomes P; Tzouanou F; Skolariki K; Vamvaka-Iakovou A; Noguera-Ortiz C; Tsirtsaki K; Waites CL; et al. "Extracellular vesicles and Alzheimer's disease in the novel era of Precision Medicine: implications for disease progression, diagnosis and treatment.". Experimental neurology (2022): https://doi.org/10.1016/j.expneurol.2022.114183.
    10.1016/j.expneurol.2022.114183
  6. Lopes M; Vieira de Castro J; Pojo M; Gonçalves CS; Eduarda P. Martins; Coimbra B; Sotiropoulos I; et al. "Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma.". Frontiers in oncology (2022): https://europepmc.org/articles/PMC8990973.
    10.3389/fonc.2022.856210
  7. Tiago Silveira-Rosa; Mateus-Pinheiro A; Silva JM; Joana Martins-Macedo; Araújo B; Machado-Santos AR; Alves ND; et al. "Suppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity.". Cell proliferation (2021): https://europepmc.org/articles/PMC8828259.
    10.1111/cpr.13165
  8. Viktoriya Zhuravleva; João Vaz-Silva; Mei Zhu; Patricia Gomes; Joana M. Silva; Nuno Sousa; Ioannis Sotiropoulos; Clarissa L. Waites. "Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aß production". Cell Death & Disease (2021): https://doi.org/10.1038/s41419-021-04433-w.
    10.1038/s41419-021-04433-w
  9. Chrysoula Dioli; Patrícia Patrício; Lucilia-Goreti Pinto; Clemence Marie; Mónica Morais; Sheela Vyas; João M. Bessa; Luisa Pinto; Ioannis Sotiropoulos. "Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress". Cell Proliferation (2021): https://doi.org/10.1111/cpr.13027.
    10.1111/cpr.13027
  10. Sotiropoulos, Ioannis. "Hippocampal NG2+ pericytes in chronically stressed rats and depressed patients: a quantitative study.". Stress (Amsterdam, Netherlands) (2020): https://doi.org/10.1080/10253890.2020.1781083.
    10.1080/10253890.2020.1781083
  11. Sotiropoulos, Ioannis. "Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain.". Neuroscience (2020): https://doi.org/10.1016/j.neuroscience.2020.05.049.
    10.1016/j.neuroscience.2020.05.049
  12. Sotiropoulos, Ioannis. "Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in Stress and Aß-evoked hippocampal pathology". Molecular Psychiatry (2020): https://doi.org/10.1038/s41380-020-0794-5.
    Aceite para publicação • 10.1038/s41380-020-0794-5
  13. Sotiropoulos, Ioannis. "Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields". Translational Psychiatry (2019): http://dx.doi.org/10.1038/s41398-019-0477-7.
    10.1038/s41398-019-0477-7
  14. Sotiropoulos, Ioannis. "Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion". Molecular Psychiatry (2019): http://dx.doi.org/10.1038/s41380-019-0484-3.
    10.1038/s41380-019-0484-3
  15. Sotiropoulos, Ioannis. "Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology". Cell Death & Differentiation (2019): http://dx.doi.org/10.1038/s41418-018-0217-1.
    10.1038/s41418-018-0217-1
  16. Sotiropoulos, Ioannis. "Activated PPAR¿ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity". Frontiers in Cellular Neuroscience (2019): http://dx.doi.org/10.3389/fncel.2019.00239.
    10.3389/fncel.2019.00239
  17. Sotiropoulos, Ioannis. "Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis". Psychopharmacology (2019): http://dx.doi.org/10.1007/s00213-018-5149-4.
    10.1007/s00213-018-5149-4
  18. Sotiropoulos, Ioannis. "Stress and the Etiopathogenesis of Alzheimer's Disease and Depression.". Advances in experimental medicine and biology (2019): https://doi.org/10.1007/978-981-32-9358-8_20.
    10.1007/978-981-32-9358-8_20
  19. Sotiropoulos, Ioannis. "Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes". European Neuropsychopharmacology (2019): http://dx.doi.org/10.1016/j.euroneuro.2018.11.1107.
    10.1016/j.euroneuro.2018.11.1107
  20. Sotiropoulos, Ioannis. "Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction". The EMBO Journal (2018): http://dx.doi.org/10.15252/embj.201899084.
    10.15252/embj.201899084
  21. Sotiropoulos, Ioannis. "Acetyl Cholinesterase Inhibitors and Cell-Derived Peripheral Inflammatory Cytokines in Early Stages of Alzheimer's Disease". Journal of Clinical Psychopharmacology (2018): http://dx.doi.org/10.1097/jcp.0000000000000840.
    10.1097/jcp.0000000000000840
  22. Sotiropoulos, Ioannis. "Atypical, non-standard functions of the microtubule associated Tau protein.". Acta neuropathologica communications (2017): http://europepmc.org/abstract/med/29187252.
    10.1186/s40478-017-0489-6
  23. Sotiropoulos, Ioannis. "Tau-dependent suppression of adult neurogenesis in the stressed hippocampus". Molecular Psychiatry (2017):
    10.1038/mp.2017.103
  24. Sotiropoulos, Ioannis. "Dendritic TAU-telidge". EBioMedicine (2017):
    10.1016/j.ebiom.2017.05.013
  25. Sotiropoulos, Ioannis. "The nucleus reuniens: a key node in the neurocircuitry of stress and depression". Molecular Psychiatry (2017): https://www.nature.com/mp/journal/vaop/ncurrent/full/mp201755a.html.
    10.1038/mp.2017.55
  26. Sotiropoulos, Ioannis. "Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology.". Molecular neurobiology (2016): http://europepmc.org/abstract/med/26328538.
    10.1007/s12035-015-9356-2
  27. Sotiropoulos, Ioannis. "Tau protein is essential for stress-induced brain pathology". Proceedings of the National Academy of Sciences USA (2016): http://www.pnas.org/content/113/26/E3755.full.
    10.1073/pnas.1600953113
  28. Lopes S; Teplytska L; Vaz-Silva J; Dioli C; Trindade R; Morais M; Webhofer C; et al. "Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria.". (2016): http://europepmc.org/abstract/med/27073221.
  29. Lopes S; Lopes A; Pinto V; Guimarães MR; Sardinha VM; Duarte-Silva S; Pinheiro S; et al. "Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment.". (2016): http://europepmc.org/abstract/med/26748966.
    10.1111/acel.12391
  30. Vyas S; Rodrigues AJ; Silva JM; Tronche F; Almeida OF; Sousa N; Sotiropoulos I. "Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration.". (2016): http://europepmc.org/abstract/med/27034847.
    10.1155/2016/6391686
  31. Moreira PS; Sotiropoulos I; Silva J; Takashima A; Sousa N; Leite-Almeida H; Costa PS. "The Advantages of Structural Equation Modeling to Address the Complexity of Spatial Reference Learning.". (2016): http://europepmc.org/abstract/med/26955327.
    10.3389/fnbeh.2016.00018
  32. Sotiropoulos I; Sousa N. "Tau as the Converging Protein between Chronic Stress and Alzheimer's Disease Synaptic Pathology.". (2016): http://europepmc.org/abstract/med/26551025.
    10.1159/000440844
  33. Sotiropoulos, Ioannis. "The neurodegenerative potential of chronic stress: a link between depression and Alzheimer's disease.". Advances in experimental medicine and biology (2015): http://europepmc.org/abstract/med/25416997.
    10.1007/978-3-319-08927-0_29
  34. Sotiropoulos I; Silva J; Kimura T; Rodrigues AJ; Costa P; Almeida OF; Sousa N; Takashima A. "Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology.". (2015): http://europepmc.org/abstract/med/25159665.
    10.3233/JAD-140693
  35. Sotiropoulos I; Lopes AT; Pinto V; Lopes S; Carlos S; Duarte-Silva S; Neves-Carvalho A; et al. "Selective impact of Tau loss on nociceptive primary afferents and pain sensation.". (2014): http://europepmc.org/abstract/med/25079367.
    10.1016/j.expneurol.2014.07.008
  36. Kimura T; Whitcomb DJ; Jo J; Regan P; Piers T; Heo S; Brown C; et al. "Microtubule-associated protein tau is essential for long-term depression in the hippocampus.". (2014): http://europepmc.org/abstract/med/24298146.
    10.1098/rstb.2013.0144
  37. Kokras, N.; Sotiropoulos, I.; Pitychoutis, P.M.; Almeida, O.F.X.; Papadopoulou-Daifoti, Z.. "Citalopram-mediated anxiolysis and differing neurobiological responses in both sexes of a genetic model of depression". Neuroscience 194 (2011): 62-71. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053122912&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2011.07.077
  38. Sotiropoulos, I.; Catania, C.; Pinto, L.G.; Silva, R.; Pollerberg, G.E.; Takashima, A.; Sousa, N.; Almeida, O.F.X.. "Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits". Journal of Neuroscience 31 21 (2011): 7840-7847. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957660658&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.0730-11.2011
  39. Kimura, T.; Fukuda, T.; Sahara, N.; Yamashita, S.; Murayama, M.; Mizoroki, T.; Yoshiike, Y.; et al. "Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss". Journal of Biological Chemistry 285 49 (2010): 38692-38699. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649660787&partnerID=MN8TOARS.
    10.1074/jbc.M110.136630
  40. Catania, C.; Sotiropoulos, I.; Silva, R.; Onofri, C.; Breen, K.C.; Sousa, N.; Almeida, O.F.X.. "The amyloidogenic potential and behavioral correlates of stress". Molecular Psychiatry 14 1 (2009): 95-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049202261&partnerID=MN8TOARS.
    10.1038/sj.mp.4002101
  41. Sotiropoulos, I.; Catania, C.; Riedemann, T.; Fry, J.P.; Breen, K.C.; Michaelidis, T.M.; Almeida, O.F.X.. "Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau". Journal of Neurochemistry 107 2 (2008): 385-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149150976&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05613.x
  42. Schubert, M.I.; Kalisch, R.; Sotiropoulos, I.; Catania, C.; Sousa, N.; Almeida, O.F.X.; Auer, D.P.. "Effects of altered corticosteroid milieu on rat hippocampal neurochemistry and structure - An in vivo magnetic resonance spectroscopy and imaging study". Journal of Psychiatric Research 42 11 (2008): 902-912. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849092638&partnerID=MN8TOARS.
    10.1016/j.jpsychires.2007.10.003
  43. Sotiropoulos, I.; Cerqueira, J.J.; Catania, C.; Takashima, A.; Sousa, N.; Almeida, O.F.X.. "Stress and glucocorticoid footprints in the brain-The path from depression to Alzheimer's disease". Neuroscience and Biobehavioral Reviews 32 6 (2008): 1161-1173. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849114710&partnerID=MN8TOARS.
    10.1016/j.neubiorev.2008.05.007
  44. Silva, R.; Mesquita, A.R.; Bessa, J.; Sousa, J.C.; Sotiropoulos, I.; Leão, P.; Almeida, O.F.X.; Sousa, N.. "Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: The role of glycogen-synthase-kinase-3ß". Neuroscience 152 3 (2008): 656-669. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949125640&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2007.12.026
  45. Cerqueira, J.J.; Catania, C.; Sotiropoulos, I.; Schubert, M.; Kalisch, R.; Almeida, O.F.X.; Auer, D.P.; Sousa, N.. "Corticosteroid status influences the volume of the rat cingulate cortex - A magnetic resonance imaging study". Journal of Psychiatric Research 39 5 (2005): 451-460. http://www.scopus.com/inward/record.url?eid=2-s2.0-21344470860&partnerID=MN8TOARS.
    10.1016/j.jpsychires.2005.01.003

Outros

Outra produção
  1. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aß production. 2021. Viktoriya Zhuravleva; João Vaz-Silva; Mei Zhu; Patricia Gomes; Joana M. Silva; Nuno Sousa; Ioannis Sotiropoulos; Clarissa L. Waites. https://doi.org/10.1101/2021.05.10.443354.
    10.1101/2021.05.10.443354
  2. MORPhA Scale: behavioral and electroencephalographic validation of a rodent anesthesia scale. 2018. Madalena Esteves; António M Almeida; Joana Silva; Pedro Silva Moreira; Emanuel Carvalho; José Miguel Pêgo; Armando Almeida; et al. https://doi.org/10.1101/475921.
    10.1101/475921
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017/09/01 - 2021/09/15 Endo-lysosomal pathway & exosome dynamics in stress-driven brain pathology: bridging dementia and depression
Orientador
 MD/PhD (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/09/15 - 2020/10/01 Identifying the role of GR signaling in Stress-driven Alzheimer's disease
Orientador
 PhD (co-tutelle) (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/06/01 - 2020/07/04 A novel RNA-targeted therapeutic approach for Alzheimer’s disease and Down syndrome
Orientador
 Master in Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/09/01 - 2019/01/16 Unraveling the synaptic role of Rab35: Implications for Alzheimer’s disease
Orientador
 MD/PhD (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/07/01 - 2018/06/15 Clarifying the role of Tau protein in the mechanisms of peripheral neuropathy
Orientador
 Master in Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/03/01 - 2017/03/04 Tau (mal)function in brain plasticity and pathology – a gateway beyond Alzheimer’s Disease
Orientador
 PhD in Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/09/01 - 2016/09/10 Peroxisome proliferator-activated receptor gamma (PPAR¿): linking peripheral metabolism with stress-related anomalies in the mouse brain
Coorientador
 PhD in Neurosciences (Doutoramento)
Ludwig-Maximilians-Universitat Munchen, Alemanha
2015/06/01 - 2016/07/06 A POSITIVE MODULATOR OF AMPA RECEPTORS AGAINST AD PATHOLOGY: IN VIVO STUDIES
Orientador
 Master in Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/06/01 - 2016/06/15 The role of Tau protein in the stress-induced changes in adult hippocampal neurogenesis
Orientador
 Master in Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/01/01 - 2015/12/15 Stress-triggered synaptic malfunction: a gate along the path from depression to dementia
Orientador
 PhD in Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/07/01 - 2015/12 Tau proteostasis in stress-triggered neuronal dysfunction: implications for Alzheimer´s disease
Orientador
 Master in Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/07/04 - 2013/12/16 Identifying the mechanistic role of Tau protein in brain´s risk and protective factors
Orientador
 Master in Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/07/01 - 2013/12/15 Dissecting the role of BACE-1 and amyloid beta in Thymus: implications for Alzheimer's disease
Orientador
 Master in Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011/07/01 - 2012/10/05 Neurodegenerative role of stress and glucocorticoid hormones through Alzheimer’s disease tau protein: a proteomic link between stress and brain pathology.
Orientador
 Master in genetics (Mestrado)
Universidade do Minho Departamento de Biologia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019/08/30 - 2019/09/02 European Behavioral Psychopharmacology (EBPS) Biennial Meeting 2019 EBPS Society
2013/10/25 - 2013/10/26 International Alzheimer’s disease Symposium “Current Aspects in Pathophysiology of Alzheimer´s disease: What do we miss?“ Medical School, University of Minho

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018/03/05 - 2018/03/10 Pathogenesis of Neurodegenerative Diseases: finding a common ground (2015, 2017, 2018) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/02/20 - 2017/03/11 Advanced Hands-on the Rodent Brain: from intracellular trafficking to brain connectome (2017, 2018) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010/09/02 - 2010/09/16 Fundamentals in Neurosciences (2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019) (Mestrado) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020/02/01 - 2023/01/31 member of the ECNP Scientific Council European College of Neuropsychopharmacology, Países Baixos
Distinções

Prémio

2021 Alzheimer’s Association Excellence in Neuroscience Mentoring Award
Alzheimer's Association, Estados Unidos

Outra distinção

2017 Premio Crioestaminal 2017
CRIOESTAMINAL, Portugal
2017 Jerome Lejeune Research Prize
Fondation Jérôme Lejeune, França
2016 Janssen Prize 2016 for the best Basic Research study
Janssen-Cilag Farmacêutica Lda, Portugal
2015 Young Investigator Award
World Federation of Societies of Biological Psychiatry, Alemanha
2014 FCT Independent Investigator award
Fundação para a Ciência e a Tecnologia, Portugal
2014 Young Faculty Award- AD/PD conference 2015
International Conference on Alzheimer's & Parkinson's Diseases, Países Baixos
2014 AAIC 2014 Fellowship Award 2014
Alzheimer's Association, Estados Unidos
2010 Best Prize APSN 2010
International Society for Neurochemistry, Suiça
2009 HIRNLIGA 2009 Senior Price
Alzheimer Forschung Initiative e V, Alemanha
2009 ECNP Fellowship Award 2009
European College of Neuropsychopharmacology, Países Baixos
2008 British Council Researcher Fellowship
British Council United States of America, Estados Unidos
2007 Post-doc grant
Japan Society for the Promotion of Science London, Reino Unido
2006 RIKEN Summer fellowship
Rikagaku Kenkyujo, Japão
2004 1st Poster Prize
Max-Planck-Institut für Psychiatrie, Alemanha
2004 GlaxoSmithKline Stiftung
GlaxoSmithKline Biologicals SA, Bélgica
2004 Marie Curie Research Training Fellowship
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Bélgica
2001 Pre-doctoral Fellowship
Deutsche Forschungsgemeinschaft, Alemanha
1999 Short-term Research Fellowship
Parkinson's Disease Foundation Inc, Estados Unidos