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Invited Assistant Professor at the Faculty of Pharmacy of the University of Coimbra since 2021, with previous teaching experience at the Faculty of Health Sciences of the University of Beira Interior. Doctoral and Master's degree in Pharmaceutical Sciences from University of Beira Interior. Academic scientific research focused on the pharmaceutical sciences field, more specifically on nanotechnology, pharmaceutical technology, and analytical chemistry. Experience in teaching Pharmaceutical Sciences, Pharmaceutical Technology, Bioanalytical Sciences, Biomedical Pharmacy, and Biomedical Sciences graduate and undergraduate students. Lecture, theoretical-practical and laboratory-type classes. Past and current subjects include (alphabetical order): Applied Pharmaceutical Development; Dermopharmacy and Cosmetics; Drugs and Medicines; Galenic Pharmacy; Galenic Pharmacy and Pharmaceutical Technology; Medical Devices; Metrology and Analytical Validation; Nanotechnology; Pharmaceutical Development of Medicines; Pharmaceutical Quality Control; Pharmaceutical Technology I; Pharmaceutical Technology II; Pharmaceutical Technology III; Quality Management; Veterinary Medicines.
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Identificação

Identificação pessoal

Nome completo
Patrícia Sofia Cabral Pires

Nomes de citação

  • Pires, Patrícia C.
  • Pires, P. C.
  • Patrícia C. Pires
  • P. C. Pires

Identificadores de autor

Ciência ID
DF1D-73CF-6BA4
ORCID iD
0000-0003-0036-4894

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Exatas - Química - Química Analítica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2016/10 - 2021/03
Concluído
 Doctoral Degree in Pharmaceutical Sciences (Doutoramento)
Universidade da Beira Interior, Portugal
"The promise of prodrugs and nanosystems in nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin" (TESE/DISSERTAÇÃO)
 Approved
2011/09 - 2016/06
Concluído
 Integrated Master's Degree in Pharmaceutical Sciences (Mestrado integrado)
Universidade da Beira Interior, Portugal
"Síntese de derivados da estrona funcionalizados nos anéis C e D como potenciais agentes anticancerígenos" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/04 - Atual Investigador visitante (Investigação) Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
2014/06 - 2021/03 Investigador (Investigação) Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/10/01 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09 - 2021/03 Monitor (Docente Universitário) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Projetos

Bolsa

Designação Financiadores
2018/09 - 2020/02 ICON: Interdisciplinary Challenges On Neurodegeneration
CENTRO-01-0145-FEDER-000013
Bolseiro de Doutoramento
Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
 Universidade da Beira Interior
Concluído
Produções

Publicações

Artigo em conferência
  1. Pires, Patrícia C.; Correia, Mafalda; Veiga, Francisco; Paiva-Santos, Ana Cláudia. "Anti-Inflammatory Drug Repurposing for Intranasal Delivery: Ketoprofen Nanoemulgel Development for the Treatment of Glioma". 2023.
    10.3390/asec2023-15345
  2. Matilde R. Rodrigues; Patrícia C. Pires; Veiga, Francisco; Ana Cláudia Paiva-Santos. "Redefining Ketoprofen: Nanoemulsion for Future Melanoma Therapeutics". 2023.
  3. Patrícia C. Pires; Correia, Mafalda; Veiga, Francisco; Ana Cláudia Paiva-Santos. "Repurposing old drugs for new targets: ketoprofen intranasal nanoemulgel development for the treatment of glioma". 2023.
  4. Joana Amado; Veiga, Francisco; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Miconazole nanoemulsions for the topical treatment of melanoma: formulation development and characterization". 2023.
  5. Maria Beatriz Pinto; Correia, Mafalda; Gabriela Moço; Amélia C. F. Vieira; Veiga, Francisco; Patrícia C. Pires; Ana Cláudia Paiva-Santos. "Niosomes development and characterization for topical delivery of hydrophobic compounds". 2023.
  6. A. Vega-Lopez; Ana Cláudia Paiva-Santos; Patrícia C. Pires; M. Dominguez Lopez; L.A. Orozco-Maldonado. "Norcantharidin nanoemulsion development, characterization and in vitro antiproliferation effect on B16F1 melanoma cells". 2023.
  7. Joana Amado; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Miconazole Nanoemulsions to Treat Melanoma: A Study of Formulation Development, Droplet Size and Solubility". 2022.
    10.3390/ecmc2022-13416
  8. P. Pires; A.C. Santos; F. Veiga. "Nanometric emulsions for the treatment of depressive and anxiety disorders". 2022.
    10.1016/j.nsa.2022.100337
  9. Jéssica Lopes Antunes; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "Brain Targeting of Antidepressant and Anxiolytic Drugs". Trabalho apresentado em Engineering Proceedings, 2022.
    10.3390/asec2022-13766
  10. Maria Ferreira; Ana Cláudia Paiva-Santos; Veiga, Francisco; Patrícia C. Pires. "The importance of nanosystems in antipsychotic drugs brain targeting". 2022.
  11. Margarida Alberto; Ana Cláudia Paiva-Santos; Veiga, Francisco; Patrícia C. Pires. "Intranasal nanoparticles for the treatment of depression and anxiety disorders". 2022.
Artigo em revista
  1. Santos, Soraia; Lopes, Joana; Lopes, Daniela; Moradialvand, Madineh; Hameed, Huma; Pires, Patrícia C.; Damiri, Fouad; et al. "Biomembrane-Derived vesicles for targeted cancer Therapies: Novel treatment avenues from Cells, Bacteria, and extracellular sources". European Journal of Pharmaceutics and Biopharmaceutics 218 (2026): 114935. https://doi.org/10.1016/j.ejpb.2025.114935.
    10.1016/j.ejpb.2025.114935
  2. Pires, Patrícia C.; Magalhães, Mariana; Cabral, Célia; Veiga, Francisco; Mazzola, Priscila Gava; Paiva-Santos, Ana Cláudia. "Development and characterization of novel intranasal in situ thermoreversible ketoprofen-loaded nanoemulgels for the treatment of glioblastoma". Journal of Drug Delivery Science and Technology 114 (2025): 107580. https://doi.org/10.1016/j.jddst.2025.107580.
    10.1016/j.jddst.2025.107580
  3. Ferreira, Patrícia; Ataide, Janaína Artem; Babaie, Soraya; Vieira, Amélia C. F.; Costa, Gustavo; Pires, Patrícia C.; Mazzola, Priscila Gava; et al. "Ectoine as a multifunctional molecule: biotechnological production and pharmaceutical applications". Drug Delivery and Translational Research (2025): https://doi.org/10.1007/s13346-025-02024-2.
    10.1007/s13346-025-02024-2
  4. Rodrigues, Sara; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.. "Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases". Drug Delivery and Translational Research (2025): https://doi.org/10.1007/s13346-025-02016-2.
    10.1007/s13346-025-02016-2
  5. Rodrigues, Matilde R.; Pires, Patrícia C.; Melero, Ana; Guillot, Antonio José; Borrego-Sánchez, Ana; Sesarman, Alina; Banciu, Manuela; Veiga, Francisco; Paiva-Santos, Ana Cláudia. "Anti-inflammatory drug repurposing in skin diseases: ketoprofen-loaded nanoemulsion development and characterization for topical administration". European Journal of Pharmacology 1004 (2025): 177992. https://doi.org/10.1016/j.ejphar.2025.177992.
    10.1016/j.ejphar.2025.177992
  6. Pinto, Maria Beatriz; Pires, Patrícia C.; Correia, Mafalda; Moço, Gabriela; Sousa-Oliveira, Inês; Sousa, Maria João; Calhelha, Ricardo C.; et al. "Propolis-Loaded Niosomes for Dermopharmaceutic and Cosmetic Applications: Development, Stability, Safety, and In Vitro Bioactivity Studies". ACS Pharmacology & Translational Science 8 7 (2025): 2220-2246. https://doi.org/10.1021/acsptsci.5c00253.
    10.1021/acsptsci.5c00253
  7. Pereira, Ana Rita; Pires, Patrícia C.; Hameed, Huma; Lopes, Daniela; Lopes, Joana; Sousa-Oliveira, Inês; Babaie, Soraya; et al. "Injectable nanocomposite hydrogels for targeted intervention in cancer, wound healing, and bone and myocardial tissue engineering". Drug Delivery and Translational Research 15 9 (2025): 2994-3077. https://doi.org/10.1007/s13346-025-01864-2.
    10.1007/s13346-025-01864-2
  8. Couceiro, Beatriz; Hameed, Huma; Vieira, Amélia C.F.; Singh, Sachin Kumar; Dua, Kamal; Veiga, Francisco; Pires, Patrícia C.; Ferreira, Laura; Paiva-Santos, Ana Cláudia. "Promoting health and sustainability: exploring safer alternatives in cosmetics and regulatory perspectives". Sustainable Chemistry and Pharmacy 43 (2025): 101901. https://doi.org/10.1016/j.scp.2024.101901.
    10.1016/j.scp.2024.101901
  9. Martínez-Razo, Gabriel; Pires, Patrícia C.; Avilez-Colin, Angélica; Domínguez-López, María Lilia; Veiga, Francisco; Conde-Vázquez, Eliezer; Paiva-Santos, Ana Cláudia; Vega-López, Armando. "Evaluation of a Norcantharidin Nanoemulsion Efficacy for Treating B16F1-Induced Melanoma in a Syngeneic Murine Model". International Journal of Molecular Sciences 26 3 (2025): 1215. https://doi.org/10.3390/ijms26031215.
    10.3390/ijms26031215
  10. Martins, Maria; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.. "Drug Repurposing and Nanotechnology for Topical Skin Cancer Treatment: Redirecting toward Targeted and Synergistic Antitumor Effects". ACS Pharmacology & Translational Science 8 2 (2025): 308-338. https://doi.org/10.1021/acsptsci.4c00679.
    10.1021/acsptsci.4c00679
  11. Gama, Francisco; Meirinho, Sara; Pires, Patrícia C.; Tinoco, Johann; Martins Gaspar, Maria Carolina; Baltazar, Graça; Alves, Gilberto; Santos, Adriana O.. "Simvastatin is delivered to the brain by high-strength intranasal cationic SMEDDS and nanoemulsions". Drug Delivery and Translational Research 15 8 (2025): 2749-2764. https://doi.org/10.1007/s13346-024-01769-6.
    10.1007/s13346-024-01769-6
  12. Faria, Marta; Ferreira-Faria, Inês; Sousa-Oliveira, Inês; Pires, Patrícia C.; Hameed, Huma; Silva, Fernando; Moço, Gabriela; et al. "Engineered biomimetic cell membrane-coated polymeric nanostructures for cancer therapy". Materials Today Chemistry 43 (2025): 102506. https://doi.org/10.1016/j.mtchem.2024.102506.
    10.1016/j.mtchem.2024.102506
  13. Pires, Patrícia C.; Renca, Andreia; Amaro, Inês; Parreiras, Lara; Anselmo, Márcia; Ferreira, Maria; Veiga, Francisco; Paiva-Santos, Ana Cláudia. "From stimuli-responsive polymers to nanosystems and electrocircuits: An update on the current state of polymeric hydrogel microneedles for wound healing". Journal of Drug Delivery Science and Technology 102 (2024): 106395. https://doi.org/10.1016/j.jddst.2024.106395.
    10.1016/j.jddst.2024.106395
  14. Ferreira, Laura; Torres, Beatriz; Hameed, Huma; Vieira, Amélia C.F.; Singh, Sachin Kumar; Dua, Kamal; Veiga, Francisco; et al. "Updated insights of active cosmetic ingredients against blue light: In vivo and in vitro evidence". Journal of Drug Delivery Science and Technology 101 (2024): 106306. https://doi.org/10.1016/j.jddst.2024.106306.
    10.1016/j.jddst.2024.106306
  15. Macário-Soares, Ana; Sousa-Oliveira, Inês; Correia, Mafalda; Pires, Patrícia C.; Sharma, Ankur; Kumar Jha, Niraj; Zare, Ehsan Nazarzadeh; et al. "Cell membrane and extracellular vesicle membrane-coated nanoparticles: An envisaged approach for the management of skin conditions". VIEW 5 6 (2024): https://doi.org/10.1002/viw.20240043.
    10.1002/viw.20240043
  16. Gonçalves, Maria Beatriz S.; Marques, Mário Pedro; Correia, Fernando; Pires, Patrícia C.; Correia, Mafalda; Makvandi, Pooyan; Varela, Carla; et al. "Wine industry by-products as a source of active ingredients for topical applications". Phytochemistry Reviews 24 5 (2024): 4065-4099. https://doi.org/10.1007/s11101-024-10030-4.
    10.1007/s11101-024-10030-4
  17. Pires, Patrícia C.; Motallebi, Mahzad; Marques, Mário Pedro; Correia, Mafalda; Sharma, Ankur; Damiri, Fouad; Hameed, Huma; et al. "Mentha aquatica (Water Mint) as a Source of Active Pharmaceutical and Cosmetic Ingredients: A Critical Review". Phytotherapy Research 38 12 (2024): 5806-5839. https://doi.org/10.1002/ptr.8337.
    10.1002/ptr.8337
  18. Corte-Real, Margarida; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.. "Improving Skin Cancer Treatment by Dual Drug Co-Encapsulation into Liposomal Systems—An Integrated Approach towards Anticancer Synergism and Targeted Delivery". Pharmaceutics 16 9 (2024): 1200. https://doi.org/10.3390/pharmaceutics16091200.
    10.3390/pharmaceutics16091200
  19. Duarte, Joana; Mascarenhas-Melo, Filipa; Pires, Patrícia C.; Veiga, Francisco; Paiva-Santos, Ana Cláudia. "Multifunctional hydrogels-based therapies for chronic diabetic wound healing". European Polymer Journal 211 (2024): 113026. https://doi.org/10.1016/j.eurpolymj.2024.113026.
    10.1016/j.eurpolymj.2024.113026
  20. Pinto, Maria Beatriz; Pires, Patrícia C.; Calhelha, Ricardo C.; Silva, Ana Rita; Sousa, Maria João; Vilas-Boas, Miguel; Falcão, Soraia I.; et al. "Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation". Pharmaceuticals 17 5 (2024): 572. https://doi.org/10.3390/ph17050572.
    10.3390/ph17050572
  21. Pires, Patrícia C.; Damiri, Fouad; Zare, Ehsan Nazarzadeh; Hasan, Anwarul; Neisiany, Rasoul Esmaeely; Veiga, Francisco; Makvandi, Pooyan; Paiva-Santos, Ana Cláudia. "A review on natural biopolymers in external drug delivery systems for wound healing and atopic dermatitis". International Journal of Biological Macromolecules 263 (2024): 130296. https://doi.org/10.1016/j.ijbiomac.2024.130296.
    10.1016/j.ijbiomac.2024.130296
  22. Sghier, Kamil; Mur, Maja; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.. "Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases". Gels 10 1 (2024): 45. https://doi.org/10.3390/gels10010045.
    10.3390/gels10010045
  23. Duarte, Joana; Sharma, Ankur; Sharifi, Esmaeel; Damiri, Fouad; Berrada, Mohammed; Khan, Moonis Ali; Singh, Sachin Kumar; et al. "Topical delivery of nanoemulsions for skin cancer treatment". Applied Materials Today 35 (2023): 102001. https://doi.org/10.1016/j.apmt.2023.102001.
    10.1016/j.apmt.2023.102001
  24. Eliana Veiga; Laura Ferreira; Mafalda Rodrigues Luis Correia; Patrícia C. Pires; Huma Hameed; Andre RTS Araujo; Letícia Caramori Cefali; et al. "Anti-aging peptides for advanced skincare: Focus on nanodelivery systems". Journal of Drug Delivery Science and Technology 89 (2023): 105087-105087. http://dx.doi.org/10.1016/j.jddst.2023.105087.
    10.1016/j.jddst.2023.105087
  25. Pires, Patrícia C.; Paiva-Santos, Ana Cláudia; Veiga, Francisco. "Liposome-Derived Nanosystems for the Treatment of Behavioral and Neurodegenerative Diseases: The Promise of Niosomes, Transfersomes, and Ethosomes for Increased Brain Drug Bioavailability". Pharmaceuticals 16 10 (2023): 1424. https://doi.org/10.3390/ph16101424.
    10.3390/ph16101424
  26. Ana Cláudia Paiva-Santos; Tatiana Gonçalves; Diana Peixoto; Patrícia C. Pires; K. Velsankar; Niraj Kumar Jha; Vivek Chavda; et al. "Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems". Molecular Pharmaceutics 20 8 (2023): 3804-3828. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00324.
    10.1021/acs.molpharmaceut.3c00324
  27. Pires, Patrícia C.; Fernandes, Mariana; Nina, Francisca; Gama, Francisco; Gomes, Maria F.; Rodrigues, Lina E.; Meirinho, Sara; et al. "Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity". Pharmaceutics 15 7 (2023): 1878. https://doi.org/10.3390/pharmaceutics15071878.
    10.3390/pharmaceutics15071878
  28. Beatriz P. Ferreira; Gustavo Costa; Filipa Mascarenhas-Melo; Patrícia C. Pires; Fariba Heidarizadeh; Prabhanjan S. Giram; Priscila Gava Mazzola; et al. "Skin applications of cannabidiol: sources, effects, delivery systems, marketed formulations and safety". Phytochemistry Reviews 22 3 (2023): 781-828. http://dx.doi.org/10.1007/s11101-023-09860-5.
    10.1007/s11101-023-09860-5
  29. Badalkhani, Omolbanin; Pires, Patrícia C.; Mohammadi, Maryam; Babaie, Soraya; Paiva-Santos, Ana Cláudia; Hamishehkar, Hamed. "Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection". Pharmaceuticals 16 5 (2023): 670. https://doi.org/10.3390/ph16050670.
    10.3390/ph16050670
  30. Cruz, Ana M.; Gonçalves, Margarida C.; Marques, Matilde S.; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.. "In Vitro Models for Anti-Aging Efficacy Assessment: A Critical Update in Dermocosmetic Research". Cosmetics 10 2 (2023): 66. https://doi.org/10.3390/cosmetics10020066.
    10.3390/cosmetics10020066
  31. Patrícia C. Pires; Filipa Mascarenhas-Melo; Kelly Pedrosa; Daniela Lopes; Joana Lopes; Ana Macário-Soares; Diana Peixoto; et al. "Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration". European Polymer Journal 187 (2023): 111868-111868. http://dx.doi.org/10.1016/j.eurpolymj.2023.111868.
    10.1016/j.eurpolymj.2023.111868
  32. Martínez-Razo, Gabriel; Pires, Patrícia C.; Domínguez-López, María Lilia; Veiga, Francisco; Vega-López, Armando; Paiva-Santos, Ana Cláudia. "Norcantharidin Nanoemulsion Development, Characterization, and In Vitro Antiproliferation Effect on B16F1 Melanoma Cells". Pharmaceuticals 16 4 (2023): 501. https://doi.org/10.3390/ph16040501.
    10.3390/ph16040501
  33. Ferreira, Laura; Pires, Patrícia C.; Fonseca, Mariana; Costa, Gustavo; Giram, Prabhanjan Shridhar; Mazzola, Priscila Gava; Bell, Victoria; et al. "Nanomaterials in Cosmetics: An Outlook for European Regulatory Requirements and a Step Forward in Sustainability". Cosmetics 10 2 (2023): 53. https://doi.org/10.3390/cosmetics10020053.
    10.3390/cosmetics10020053
  34. Antunes, Jéssica L.; Amado, Joana; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.. "Nanosystems, Drug Molecule Functionalization and Intranasal Delivery: An Update on the Most Promising Strategies for Increasing the Therapeutic Efficacy of Antidepressant and Anxiolytic Drugs". Pharmaceutics 15 3 (2023): 998. https://doi.org/10.3390/pharmaceutics15030998.
    10.3390/pharmaceutics15030998
  35. Ferreira, Maria Daniela; Duarte, Joana; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.. "Nanosystems for Brain Targeting of Antipsychotic Drugs: An Update on the Most Promising Nanocarriers for Increased Bioavailability and Therapeutic Efficacy". Pharmaceutics 15 2 (2023): 678. https://doi.org/10.3390/pharmaceutics15020678.
    10.3390/pharmaceutics15020678
  36. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Nano and Microemulsions for the Treatment of Depressive and Anxiety Disorders: An Efficient Approach to Improve Solubility, Brain Bioavailability and Therapeutic Efficacy". Pharmaceutics 14 12 (2022): 2825-2825. http://dx.doi.org/10.3390/pharmaceutics14122825.
    10.3390/pharmaceutics14122825
  37. Margarida Alberto; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders". Pharmaceutics 14 12 (2022): 2742-2742. http://dx.doi.org/10.3390/pharmaceutics14122742.
    10.3390/pharmaceutics14122742
  38. Joana Lopes; Daniela Lopes; Ana Macário-Soares; Inês Ferreira-Faria; Diana Peixoto; Mahzad Motallebi; Imran Mohammad; et al. "Cell Membrane-Coated Biomaterials for Bone Cancer-Targeted Diagnosis and Therapy: A Critical Update on Osteosarcoma Applications". Materials Chemistry Horizons (2022): https://doi.org/10.22128/mch.2022.615.1032.
    10.22128/mch.2022.615.1032
  39. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Antipsychotics-Loaded Nanometric Emulsions for Brain Delivery". Pharmaceutics 14 10 (2022): 2174-2174. http://dx.doi.org/10.3390/pharmaceutics14102174.
    10.3390/pharmaceutics14102174
  40. Pires, Patrícia C.; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs". Pharmaceutics 14 3 (2022): 588. https://doi.org/10.3390/pharmaceutics14030588.
    10.3390/pharmaceutics14030588
  41. Canário, Catarina; Matias, Mariana; Brito, Vanessa; Pires, Patrícia; Santos, Adriana O.; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. "C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies". Applied Sciences 12 7 (2022): 3579. https://doi.org/10.3390/app12073579.
    10.3390/app12073579
  42. Pires, Patrícia C.; Fazendeiro, Ana C.; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.". European Journal of Pharmaceutical Sciences 164 (2021): 105918. https://doi.org/10.1016/j.ejps.2021.105918.
    10.1016/j.ejps.2021.105918
  43. Pires, Patrícia C.; Santos, Liliana T.; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Intranasal fosphenytoin: The promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs". International Journal of Pharmaceutics 592 (2021): 120040. https://doi.org/10.1016/j.ijpharm.2020.120040.
    10.1016/j.ijpharm.2020.120040
  44. Pires, Patrícia C.; Peixoto, Diana; Teixeira, Isaura; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization". European Journal of Pharmaceutical Sciences 141 (2020): 105099. https://doi.org/10.1016/j.ejps.2019.105099.
    10.1016/j.ejps.2019.105099
  45. Pires, Patrícia C.; Santos, Adriana O.. "Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies". Journal of Controlled Release 270 (2018): 89-100. https://doi.org/10.1016/j.jconrel.2017.11.047.
    10.1016/j.jconrel.2017.11.047
Capítulo de livro
  1. Pires, Patrícia C.; Melo, Dora; Santos, Adriana O.. "Intranasal delivery of antiseizure drugs". In Drug Delivery Devices and Therapeutic Systems, editado por Eric Chappel, 623-646. Elsevier, 2021.
    Publicado • 10.1016/b978-0-12-819838-4.00022-5
Poster em conferência
  1. Fernando Silva; Francisco Veiga; Patrícia C. Pires; Amélia C. F. Vieira; Vera Moura; Ana Cláudia Paiva-Santos. "Development of a nanoemulsion for intravenous administration of paracetamol in combination with ketoprofen". Trabalho apresentado em XIX International CICS-UBI Symposium, 2024.
  2. Francisco Veiga; Patrícia C. Pires; Matilde Rodrigues; Ana Cláudia Paiva-Santos. "Drug repurposing and nanosystems for the treatment of glioma: ketoprofen nanoemulgel development and characterization". Trabalho apresentado em Controlled Release Society 2023 Annual Meeting & Expo, 2023.
  3. Matilde Rodrigues; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Drug repurposing and nanosystems for the treatment of melanoma: Novel ketoprofen nanoemulsion development and characterization". Trabalho apresentado em In4Med, 2023.
  4. Joana Amado; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Formulation development and characterization of miconazole nanoemulsions for melanoma treatment". Trabalho apresentado em In4Med, 2023.
  5. Maria Beatriz Pinto; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Encapsulation of hydrophilic compounds into niosomes for skin application". Trabalho apresentado em In4Med, 2023.
  6. Miriana Griesi; Patrícia C. Pires; Francisco Veiga; Giovanni Tosi; Ana Cláudia Paiva-Santos. "Development of a novel nanoemulgel for topical delivery of hydrophobic compounds". Trabalho apresentado em In4Med, 2023.
  7. Maria Beatriz Pinto; Mafalda Correia; Moço, Gabriela; Amélia Vieira; Francisco Veiga; Patrícia C. Pires; Ana Cláudia Paiva-Santos. "Niosomes development and characterization for topical delivery of hydrophobic compounds". Trabalho apresentado em X Congresso Iberoamericano das Ciências Farmacêuticas, Coimbra, Portugal, 2023.
  8. Patrícia C. Pires; Mafalda Correia; Francisco Veiga; Ana Cláudia Paiva-Santos. "Repurposing old drugs for new targets: Ketoprofen intranasal nanoemulgel development for the treatment of glioma". Trabalho apresentado em X Congresso Iberoamericano das Ciências Farmacêuticas, Coimbra, Portugal, 2023.
  9. Joana Amado; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Miconazole nanoemulsions for the topical treatment of melanoma: Formulation development and characterization". Trabalho apresentado em X Congresso Iberoamericano das Ciências Farmacêuticas, Coimbra, Portugal, 2023.
  10. Joana Amado; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Miconazole nanoemulsions to treat melanoma: formulation development and droplet size and solubility studies". Trabalho apresentado em 8th International Electronic Conference on Medicinal Chemistry, 2022.
  11. Ana Cláudia Paiva-Santos; Matilde Rodrigues; Patrícia C. Pires; Francisco Veiga. "Ketoprofen Nanoemulsions for Melanoma Treatment: Formulation, Development and Characterization". Trabalho apresentado em 13th Annual Meeting on Skin Ageing & Challenges, 2022.
  12. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Improving drug solubility and brain bioavailability of antipsychotics through nanometric emulsions". Trabalho apresentado em 35th European College of Neuropsychopharmacology (ECNP) Congress, 2022.
  13. Matilde Rodrigues; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Ketoprofen nanoemulsions for cancer treatment". Trabalho apresentado em 17th YES - Young European Scientist Meeting, 2022.
  14. Patrícia C. Pires; Matilde Rodrigues; Ana Cláudia Paiva-Santos; Francisco Veiga. "Intranasal ketoprofen nanoemulgels for brain cancer treatment: formulation development and characterization". Trabalho apresentado em XVII International CICS-UBI Symposium, 2022.
  15. Gama, Francisco; Meirinho, Sara; Patrícia C. Pires; Adriana O. Santos. "Desenvolvimento de Micro e Nanoemulsões para Entrega Intranasal de Sinvastatina em AVC". Trabalho apresentado em 16º Congresso Português do AVC, 2022.
  16. Francisca S. Nina; Patrícia C. Pires; SANTOS, ADRIANA O.. "Otimização de nanoemulsões óleo-em-água com caraterísticas ideais de composição e tamanho de gotícula". Trabalho apresentado em VI Congresso Científico Anual UBIPharma, 2020.
  17. Patrícia C. Pires; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Brain delivery of poorly soluble drugs: a proof-of-concept of phosphate esters as a way of increasing solubility and bioavailability". Trabalho apresentado em Controlled Release Society Virtual Annual Meeting, 2020.
  18. Patrícia C. Pires; Liliana T. Santos; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin - formulation development, in vitro characterization and in vivo pharmacokinetics". Trabalho apresentado em FENS 2020 Virtual Forum, 2020.
  19. Patrícia C. Pires; Ana C. Fazendeiro; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Nose-to-brain delivery of microemulsions containing phenytoin and fosphenytoin: formulation development and pharmacokinetics". Trabalho apresentado em XV Annual CICS-UBI Symposium, 2020.
  20. Dora Melo; Patrícia C. Pires; Adriana O. Santos. "A review of the clinical application of intranasal benzodiazepines in the treatment of epilepsy". Trabalho apresentado em XIV Annual CICS-UBI Symposium, 2019.
  21. Patrícia C. Pires; Márcio Rodrigues; Gilberto Alves; Adriana O. Santos. "Simultaneous quantification of phenytoin and fosphenytoin in mouse blood and brain using high-performance liquid chromatography: a tool for in vivo studies". Trabalho apresentado em 6th European Chemical Biology Symposium, 2019.
  22. Patrícia C. Pires; Liliana T. Santos; Márcio Rodrigues; Gilberto Alves; Adriana O. Santos. "Novel fosphenytoin formulations for intranasal administration - development, characterization and in vitro release studies". Trabalho apresentado em 3rd European Conference on Pharmaceutics, 2019.
  23. Liliana T. Santos; Patrícia C. Pires; SANTOS, ADRIANA O.. "Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis". Trabalho apresentado em X Beira Interior Medical Meeting, 2019.
  24. Patrícia C. Pires; Adriana O. Santos. "Brain drug delivery by intranasal nanosystems: a systematic review of pre-clinical studies". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  25. Joana Ferreira; Patrícia C. Pires; Gilberto Alves; SANTOS, ADRIANA O.. "The contribution of carbomer in pluronic-based thermoreversible gels of carbamazepine". Trabalho apresentado em 13th International Chemical and Biological Engineering Conference, 2018.
  26. Catarina Canário; Patrícia C. Pires; Mariana Matias; Vanessa de Brito; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto Alves. "Steroidal estrone oximes: cytotoxic effects on hormone-dependent cancer cell lines". Trabalho apresentado em XI Annual CICS-UBI Symposium, 2016.
Recurso online
  1. Patrícia C. Pires. Nanoemulgels: nanoemulsion and hydrogel hybrids as polymeric nanocomposites for improved drug delivery. 2025. https://sciforum.net/paper/view/27072.
  2. Ana Filipa São Pedro; Veiga, Francisco; Ana Cláudia Paiva-Santos; Patrícia C. Pires. Synergistic triple drug co-loaded nanoplatforms for improved cancer treatment. 2025. https://sciforum.net/paper/view/25604.
  3. Maria Anastácio; Veiga, Francisco; Ana Cláudia Paiva-Santos; Patrícia C. Pires. Innovative nanoplatforms with simultaneous triple drug co-delivery for improved synergistic therapeutic effects. 2025. https://sciforum.net/paper/view/25628.
  4. Mariana S. Antunes; Ana Macário-Soares ; Veiga, Francisco; Patrícia C. Pires; Ana Cláudia Paiva-Santos. Co-encapsulation of phytocompounds in liposomes for enhanced wound healing: development and physicochemical characterization. 2025. https://sciforum.net/paper/view/24059.
  5. Nádia B. Santos; Ana Macário-Soares ; Mariana S. Antunes; Veiga, Francisco; Patrícia C. Pires; Ana Cláudia Paiva-Santos. Development and characterization of novel plant-extract-loaded liposomes for dermopharmaceutical and cosmetic applications. 2025. https://sciforum.net/paper/view/24049.
  6. Patrícia C. Pires. Recent advances in nanomedicine for skin cancer immunotherapy - a focus on nanosystems, drug repurposing and co-loading for synergistic effects. 2025. https://sciforum.net/paper/view/22458.
  7. Matilde de Simão Marques; Patrícia C. Pires; Antonio José Guillot; Ana Melero; Veiga, Francisco; Ana Cláudia Paiva-Santos. Thermoresponsive hydrogel loaded with clobetasol PLGA nanoparticles for the treatment of inflammatory skin diseases: formulation development and characterization. 2024. https://sciforum.net/paper/view/21046.
  8. Margarida Corte-Real; Veiga, Francisco; Ana Cláudia Paiva-Santos; Patrícia C. Pires. Advancing skin cancer treatment through dual drug loading into liposome-derived nanosystems. 2024. https://sciforum.net/paper/view/21112.
  9. Kamil Sghier; Maja Mur; Veiga, Francisco; Ana Cláudia Paiva-Santos; Patrícia C. Pires. Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology. 2024. https://encyclopedia.pub/entry/53599.
  10. Laura Ferreira; Patrícia C. Pires; Fonseca, Mariana; Gustavo Costa; Giram, Prabhanjan S.; Mazzola, Priscila Gava; Bell, Victoria; et al. Nanomaterials in Cosmetics. 2023. https://encyclopedia.pub/entry/42715.
  11. Matilde R. Rodrigues; Patrícia C. Pires; Veiga, Francisco; Ana Cláudia Paiva-Santos. Redefining Ketoprofen: Nanoemulsion for Future Melanoma Therapeutics. 2023. https://sciforum.net/paper/view/15724.
  12. Patrícia C. Pires; Correia, Mafalda; Veiga, Francisco; Ana Cláudia Paiva-Santos. Anti-inflammatory drug repurposing for intranasal delivery: ketoprofen nanoemulgel development for the treatment of glioma. 2023. https://sciforum.net/paper/view/15345.
  13. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Veiga, Francisco. Liposome-Derived Nanosystems for Increased Brain Drug Bioavailability. 2023. https://encyclopedia.pub/entry/50195.
  14. Ana M. Cruz; Margarida C. Gonçalves; Matilde S. Marques; Veiga, Francisco; Ana Cláudia Paiva-Santos; Patrícia C. Pires. In Vitro Models for Anti-Aging Efficacy Assessment. 2023. https://encyclopedia.pub/entry/43562.
  15. Jéssica L. Antunes; Joana Amado; Veiga, Francisco; Ana Cláudia Paiva-Santos; Patrícia C. Pires. Enhancing Brain Drug Bioavailability in Depression and Anxiety. 2023. https://encyclopedia.pub/entry/42637.
  16. Maria Ferreira; Duarte, Joana; Veiga, Francisco; Ana Cláudia Paiva-Santos; Patrícia C. Pires. Second Generation Antipsychotics. 2023. https://encyclopedia.pub/entry/41699.
  17. Margarida Alberto; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. Intranasal Nanoparticles for the Treatment of Depression and Anxiety Disorders. 2022. https://sciforum.net/paper/view/13853.
    10.3390/asec2022-13853
  18. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. Nanosystems for Brain Drug Delivery. 2022. https://encyclopedia.pub/entry/33306.
  19. Margarida Alberto; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. Lipid and Polymeric Nanoparticles for Brain Drug Delivery. 2022. https://encyclopedia.pub/entry/38768.
  20. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. Nano and Microemulsions for Depression and Anxiety Treatment. 2022. https://encyclopedia.pub/entry/39040.
  21. Joana Amado; Patrícia C. Pires; Veiga, Francisco; Ana Cláudia Paiva-Santos. Miconazole nanoemulsions to treat melanoma: formulation development and droplet size and solubility studies. 2022. https://sciforum.net/paper/view/13416.
  22. Jéssica Antunes; Ana Cláudia Paiva-Santos; Veiga, Francisco; Patrícia C. Pires. Brain targeting of antidepressant and anxiolytic drugs. 2022. https://sciforum.net/paper/view/13766.
  23. Maria Ferreira; Ana Cláudia Paiva-Santos; Veiga, Francisco; Patrícia C. Pires. The importance of nanosystems in antipsychotic drugs brain targeting. 2022. https://sciforum.net/paper/view/13765.
  24. Patrícia C. Pires; Rodrigues, Márcio; Alves, Gilberto; SANTOS, ADRIANA O.. Strategies to Improve Drug Strength in Nasal Preparations. 2022. https://encyclopedia.pub/entry/33359.
Resumo em conferência
  1. Patrícia C. Pires. "Nanoemulgels: nanoemulsion and hydrogel hybrids as polymeric nanocomposites for improved drug delivery". Trabalho apresentado em The 3rd International Online Conference on Polymer Science, 2025.

Propriedade Intelectual

Patente
  1. SANTOS, ADRIANA O.; Mariana Carvalho Fernandes; Patrícia C. Pires; Alves, Gilberto; Ana Carolina Maricoto Fazendeiro; Francisca Matos Silva Pereira Nina; Maria De Fátima da Silva Ferreira Gomes; Rodrigues, Lina. 2021. "Emulsão homogénea para entrega de agentes ativos, seus métodos e usos/ Self-emulsifying composition, production methods and uses thereof".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2025 Nanoemulgels: nanoemulsion and hydrogel hybrids as polymeric nanocomposites for improved drug delivery The 3rd International Online Conference on Polymer Science
2019/11 Intranasal administration of fosphenytoin: assay development and validation and preliminary in vivo pharmacokinetic studies III International Congress in Health Sciences Research
(Covilhã, Portugal)
2019/07 Formulation development and in vitro characterization of nanoemulsions and nanoemulgels of phenytoin and fosphenytoin for intranasal administration XIV Annual CICS-UBI Symposium
(Covilhã, Portugal)
2018/07 Thermosensitive and mucoadhesive polymers in intranasal drug delivery: fosphenytoin formulation development and characterization XIII Annual CICS-UBI Symposium
(Covilhã, Portugal)
2017 Modifications of estrone in C- and D-ring: synthesis, biological evaluation and docking studies XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020 - 2021 Eficácia da administração intranasal de micro e nanoemulsões na biodisponibilidade e direcionamento cerebral de fármacos de baixa massa molecular
Coorientador
 Pharmaceutical Sciences (Mestrado)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2020 - 2021 Otimização de nanoemulsões óleo-em-água com caraterísticas ideais de composição e tamanho de gotícula
Coorientador
 Pharmaceutical Sciences (Mestrado)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2019 - 2021 Formulação de emulsões nanométricas de fenitoina e fosfenitoina
Coorientador de Ana C. Fazendeiro
 Pharmaceutical Sciences (Mestrado)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2019 - 2020 Revisão de modelos de epitélio nasal humano nos estudos pré-clínicos de segurança
Coorientador de Iryna Denysyuk
 Pharmaceutical Sciences (Mestrado)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018 - 2019 Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis
Coorientador de Liliana T. Santos
 Pharmaceutical Sciences (Mestrado)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018 - 2019 Revisão da aplicação clínica de benzodiazepinas pela via intranasal no tratamento da epilepsia
Coorientador de Dora Melo
 Pharmaceutical Sciences (Mestrado)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2024 - Atual Vogal do procedimento concursal para atribuição de 2 bolsas de investigação para mestre do projeto “Panthermicell - Micelas Biomiméticas à Base de Vitamina e Revestidas por Membrana Celular para Nanoteranóstica Multimodal do Cancro do Pâncreas”, IT137-24-91 Universidade de Coimbra Faculdade de Farmácia, Portugal
2023 - Atual Vogal do procedimento concursal para atribuição de 1 bolsa de investigação para doutorado do projeto “NanoBioGel - Hidrogel de nanotubos de argila haloisite com revestimento biomimético à base de produtos naturais para a cicatrização cutânea de feridas”, IT137-23-240 Universidade de Coimbra Faculdade de Farmácia, Portugal
2023 - Atual Vogal do procedimento concursal para atribuição de 1 bolsa de investigação para licenciado do projeto “NanoBioGel - Hidrogel de nanotubos de argila haloisite com revestimento biomimético à base de produtos naturais para a cicatrização cutânea de feridas”, IT137-23-241 Universidade de Coimbra Faculdade de Farmácia, Portugal
2023 - Atual Vogal do procedimento concursal para atribuição de 2 bolsas de investigação para mestre do projeto “Panthermicell - Micelas Biomiméticas à Base de Vitamina e Revestidas por Membrana Celular para Nanoteranóstica Multimodal do Cancro do Pâncreas”, IT137-23-049 Universidade de Coimbra Faculdade de Farmácia, Portugal

Tutoria

Tópico Nome do aluno
2023 - Atual Kamil Sghier
2023 - Atual Maja Mur
2023 - Atual Joana Amado
Distinções

Prémio

2019 Best Oral Communication in the "III International Congress in Health Sciences Research", Covilhã, Portugal
Universidade da Beira Interior Instituto Coordenador da Investigação, Portugal