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Helena Maria Cabral Marques. Completed the Título de Agregado in Provas de Agregação in 2005/01 by Universidade de Lisboa Faculdade de Farmácia, Licenciatura in Ciências Farmacêuticas/Farmácia de Oficina Hospitalar in 1985 by Universidade de Lisboa Faculdade de Farmácia, Doctor of Philosophy in Philosophy Doctor in Pharmaceutics in 1991 by University of Wales College of Cardiff (UWCC) and Doctor of Philosophy in Doutoramento em Farmácia in 1992 by Universidade de Lisboa Faculdade de Farmácia. Is Associate Professor in Universidade de Lisboa Faculdade de Farmácia, Member of the Comissão da Farmacopeia Portuguesa in Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Head of Pharmaceutical Technology Department in Universidade de Lisboa Faculdade de Farmácia, Erasmus Coordinator in Universidade de Lisboa Faculdade de Farmácia and Researcher in Universidade de Lisboa Instituto de Investigação do Medicamento. Published 57 articles in journals. Has 1 book(s). Supervised 1 PhD thesis(es). Co-supervised 1 MSc dissertation(s). Has received 1 awards and/or honors. Works in the area(s) of Medical and Health Sciences. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Analytical methods; Complexation methods; Dimethyl-beta-cyclodextrin; Stoichiometry complexes; Tretinoin; Valved Holding Chamber (VHC); Emitted Dose; Asthma; Science & Technology; Chemistry, Multidisciplinary; Crystallography; Fine Particle Mass; Performance Index; Experimental evaluation; b-Cyclodextrin; Capsule; Compaction; Dissolution; Ibuprofen; Minitablet; Controlled release; Cyclodextrin; Inclusion complex; Solid dosage forms; Solubility; Ciências Farmacêuticas; Enfermagem; Formação Pré-graduada; Medicina; Medicina Dentária; Tabagismo; ß-cyclodextrin; dissolution; ibuprofen; pellet; tablet; Indomethacin; Freeze-drying; Spray-drying; Physical mixture; Kneading; NMR; X-ray; Optical microscopy; FT-IR spectroscopy; UV spectroscopy; DSC; Big data; Farmácia; Análise; Visualização de dados; Teses de mestrado - 2015; Ciências da Saúde; .
Identificação

Identificação pessoal

Nome completo
Helena Maria Cabral Marques

Nomes de citação

  • Marques, Helena
  • Cabral-Marques, Helena
  • Cabral Marques, Helena

Identificadores de autor

Ciência ID
DB1F-B511-D3F2
ORCID iD
0000-0002-9255-4697
Google Scholar ID
qmcKDogAAAAJ&hl
Researcher Id
A-9739-2014
Scopus Author Id
6603071227

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2005/01
Concluído
Provas de Agregação (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1992
Concluído
Doutoramento em Farmácia (Doctor of Philosophy)
Especialização em Tecnologia Farmacêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
Approved
1991
Concluído
Philosophy Doctor in Pharmaceutics (Doctor of Philosophy)
University of Wales College of Cardiff (UWCC), Reino Unido
"Salbutamol - cyclodextrin inclusion complexes for pulmonary drug delivery" (TESE/DISSERTAÇÃO)
Equivalência ao grau de DOUTOR
1986
Concluído
Química Orgânica e Tecnológica (Pós-Graduação)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Frequência com aproveitamento da parte escolar
1985
Concluído
Ciências Farmacêuticas/Farmácia de Oficina Hospitalar (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
15/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2008 - Atual Investigador (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012 - 2016 Investigador Coordenador (carreira) (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
1995 - 2009 Investigador (Investigação) Unidade de Ciências e Tecnologia Farmacêuticas, Portugal
1998 - 2000 Investigador (Investigação) Alexander von Humboldt-Stiftung, Alemanha
1997 - 2000 Pós-doutorado (Investigação) Eberhard Karls Universität Tübingen Fachbereich VI Pharmazie und Biochemie, Alemanha
1993 - 1993 Pós-doutorado (Investigação) Université Paris Descartes, França

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2000/05/18 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2015 Professor Associado Convidado (Docente Universitário) Université Claude Bernard Lyon 1, França
1992 - 2000 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
1986 - 1991 Assistente Estagiário (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2014/07/01 - Atual Erasmus Coordinator Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/04/01 - 2019 Head of Pharmaceutical Technology Department Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Conselho científico/técnico-científico ou orgão correspondente Universidade de Lisboa, Portugal
2017 - 2018 Conselho geral ou orgão correspondente Universidade de Lisboa, Portugal
2016 - 2017 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Lisboa, Portugal
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Lisboa Faculdade de Farmácia, Portugal
2005/12/16 - 2007/07/20 Head of Pharmaceutical Technology Department Universidade de Lisboa Faculdade de Farmácia, Portugal
2000 - 2001 Vice-president of the Scientific Board Universidade de Lisboa Faculdade de Farmácia, Portugal
1992/04/01 - 2001 Member of the Coordinating Commission of Scientific Board Universidade de Lisboa Faculdade de Farmácia, Portugal
1987 - 1987 Member elected for the Assembleia da Universidade Universidade de Lisboa, Portugal
1987 - 1987 Member elected for the Senado Universitário Universidade de Lisboa, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
1993 - Atual Member of the Comissão da Farmacopeia Portuguesa Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
1987/09/29 - 1991/03/31 FCT grantee University of Wales College of Cardiff (UWCC), Reino Unido
Projetos

Projeto

Designação Financiadores
2010 - 2013/12 Lung CYD-DDS (cyclodextrin-based drug delivery systems) for inhalation
PTDC/SAU-FCF/098733/2008
Investigador responsável
2007 - 2010/03 Green” production of cyclodextrin-based matrixes using supercritical carbon dioxide
PTDC/QUI/66086/2006
Bolseiro de Investigação
2002 - 2004 Resolution of racemic mixtures of pharmaceutical active substances using membrane contactors
POCTI/FCB/43942/2001
Investigador responsável
1999 - 2000 Aerossoles de pós para inalação
PEDIP II, Acção B, Medida 3.2
Investigador responsável
1995 - 1997 Novos sistemas terapêuticos
SINDEPEDIP / PEDIP II
Bolseiro de Investigação
Produções

Publicações

Artigo em conferência
  1. Oliveira, R.F.; Teixeira, S.F.; Marques, H.M.C.; Teixeira, J.C.. "A correlative cfd study between recirculation area and fpm in VHC design". 2016.
    10.1115/IMECE2016-67329
  2. Oliveira, Ricardo Falcão; Marques, Helena Maria Cabral; Machado, A. V.; Teixeira, J. Carlos; Teixeira, S. F. C. F.. "VHC performance evaluation at constant flow: 30 L/MIN". 2016.
    10.1115/IMECE201552283
  3. Oliveira, R.F.; Flores, P.; Teixeira, S.F.; Marques, H.M.C.; Teixeira, J.C.. "A form-closed cam-follower mechanism for a breath simulator machine". 2015.
    10.1007/978-3-319-09411-3_14
  4. Oliveira, R.F.; Marques, H.M.C.; Machado, A.V.; Teixeira, J.C.; Teixeira, S.F.. "VHC performance evaluation at constant flow: 30 L/MIN". 2015.
    10.1115/IMECE201552283
  5. Oliveira, Ricardo Falcão; Silva, Manuel Viana; Machado, A. V.; Oliveira, Manuel António Sousa Cortez Gonçalves; Marques, Helena Maria Cabral; Teixeira, S. F. C. F.; Teixeira, J. Carlos. "Experimental assessment of Emitted Dose from Valved Holding Chamber devices". 2015.
    10.1115/IMECE201438846
  6. Oliveira, R.F.; Silva, M.V.; Machado, A.V.; Oliveira, M.; Cabral-Marques, H.M.; Teixeira, S.F.; Teixeira, J.C.. "Experimental assessment of Emitted Dose from Valved Holding Chamber devices". 2014.
    10.1115/IMECE201438846
  7. Oliveira, R.F.; Teixeira, S.F.; Cabral-Marques, H.; Teixeira, J.C.. "Flow recirculation in VHC designs". 2014.
  8. Oliveira, R.F.; Teixeira, J.C.; Marques, H.M.C.; Teixeira, S.F.. "An experimental setup for API assessment of a valved holding chamber device". 2013.
    10.1115/IMECE2013-65111
  9. Oliveira, R.F.; Ferreira, A.C.; Teixeira, S.F.; Teixeira, J.C.; Marques, H.C.. "PMDI spray plume analysis: ACFD study". 2013.
  10. Oliveira, R.F.; Teixeira, J.C.; Marques, H.M.C.; Teixeira, S.. "Modeling flow recirculation inside a holding chamber". 2012.
    10.1115/IMECE2012-88242
Artigo em revista
  1. Conceição, J.; Adeoye, O.; Cabral-Marques, H.; Concheiro, A.; Alvarez-Lorenzo, C.; Sousa Lobo, J.M.. "Carbamazepine bilayer tablets combining hydrophilic and hydrophobic cyclodextrins as a quick/slow biphasic release system". Journal of Drug Delivery Science and Technology 57 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85081695963&partnerID=MN8TOARS.
    10.1016/j.jddst.2020.101611
  2. Adeoye, O.; Conceição, J.; Serra, P.A.; Bento da Silva, A.; Duarte, N.; Guedes, R.C.; Corvo, M.C.; et al. "Cyclodextrin solubilization and complexation of antiretroviral drug lopinavir: In silico prediction; Effects of derivatization, molar ratio and preparation method". Carbohydrate Polymers 227 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072659617&partnerID=MN8TOARS.
    10.1016/j.carbpol.2019.115287
  3. Adeoye, O.; Bártolo, I.; Conceição, J.; da Silva, A.B.; Duarte, N.; Francisco, A.P.; Taveira, N.; Cabral-Marques, H.. "Pyromellitic dianhydride crosslinked soluble cyclodextrin polymers: Synthesis, lopinavir release from sub-micron sized particles and anti-HIV-1 activity". International journal of pharmaceutics 583 (2020): 119356-119356. http://www.scopus.com/inward/record.url?eid=2-s2.0-85085265878&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2020.119356
  4. Conceição, J.; Adeoye, O.; Cabral-Marques, H.; Concheiro, A.; Alvarez-Lorenzo, C.; Sousa Lobo, J.M.. "Orodispersible Carbamazepine/Hydroxypropyl-ß-Cyclodextrin Tablets Obtained by Direct Compression with Five-in-One Co-processed Excipients". AAPS PharmSciTech 21 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077328508&partnerID=MN8TOARS.
    10.1208/s12249-019-1579-5
  5. Pinto, L.M.A.; Adeoye, O.; Thomasi, S.S.; Francisco, A.P.; Carvalheiro, M.C.; Cabral-Marques, H.. "Preparation and characterization of a synthetic curcumin analog inclusion complex and preliminary evaluation of in vitro antileishmanial activity". International Journal of Pharmaceutics 589 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090007205&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2020.119764
  6. Conceição, J.; Farto-Vaamonde, X.; Goyanes, A.; Adeoye, O.; Concheiro, A.; Cabral-Marques, H.; Sousa Lobo, J.M.; Alvarez-Lorenzo, C.. "Hydroxypropyl-ß-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing". Carbohydrate Polymers 221 (2019): 55-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066472073&partnerID=MN8TOARS.
    10.1016/j.carbpol.2019.05.084
  7. Dogbe, M.G.; Mafilaza, A.Y.; Eleutério, C.V.; Cabral-Marques, H.; Simões, S.; Gaspar, M.M.. "Pharmaceutical benefits of fluticasone propionate association to delivery systems: In vitro and in vivo evaluation". Pharmaceutics 11 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074053330&partnerID=MN8TOARS.
    10.3390/pharmaceutics11100521
  8. Conceição, J.; Adeoye, O.; Cabral-Marques, H.M.; Sousa Lobo, J.M.. "Hydroxypropyl-ß-Cyclodextrin and ß-Cyclodextrin as Tablet Fillers for Direct Compression". AAPS PharmSciTech (2018): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049577709&partnerID=MN8TOARS.
    10.1208/s12249-018-1115-z
  9. Conceição, J.; Adeoye, O.; Cabral-Marques, H.M.; Lobo, J.M.S.. "Cyclodextrins as excipients in tablet formulations". Drug Discovery Today 23 6 (2018): 1274-1284. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046167160&partnerID=MN8TOARS.
    10.1016/j.drudis.2018.04.009
  10. Adeoye, O.; Costa, C.; Casimiro, T.; Aguiar-Ricardo, A.; Cabral-Marques, H.. "Preparation of ibuprofen/hydroxypropyl-G-cyclodextrin inclusion complexes using supercritical CO2-assisted spray drying". Journal of Supercritical Fluids 133 (2018): 479-485. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034636823&partnerID=MN8TOARS.
    10.1016/j.supflu.2017.11.009
  11. Vieira da Silva, S.A.; Clemente, A.; Rocha, J.; Direito, R.; Marques, H.C.; Sepodes, B.; Figueira, M.-E.; Ribeiro, M.H.. "Anti-inflammatory effect of limonin from cyclodextrin (un)processed orange juices in in vivo acute inflammation and chronic rheumatoid arthritis models". Journal of Functional Foods 49 (2018): 146-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051776212&partnerID=MN8TOARS.
    10.1016/j.jff.2018.08.024
  12. Conceição, J.; Adeoye, O.; Cabral-Marques, H.M.; Lobo, J.M.S.. "Cyclodextrins as drug carriers in pharmaceutical technology: The state of the art". Current Pharmaceutical Design 24 13 (2018): 1405-1433. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050355627&partnerID=MN8TOARS.
    10.2174/1381612824666171218125431
  13. Adeoye, O.; Cabral-Marques, H.. "Cyclodextrin nanosystems in oral drug delivery: A mini review". International Journal of Pharmaceutics 531 2 (2017): 521-531. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019372233&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2017.04.050
  14. Ascenso, A.; Pedrosa, T.; Pinho, S.; Pinho, F.; De Oliveira, J.M.P.F.; Marques, H.C.; Oliveira, H.; Simões, S.; Santos, C.. "The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes". Oxidative Medicine and Cellular Longevity 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84948844263&partnerID=MN8TOARS.
    10.1155/2016/8214631
  15. Arriagas, N.; Cabral-Marques, H.. "Obtention and characterization of a ciclesonide: Methyl-beta cyclodextrin complex". Journal of Inclusion Phenomena and Macrocyclic Chemistry 80 1-2 (2014): 125-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922418845&partnerID=MN8TOARS.
    10.1007/s10847-014-0416-4
  16. Couto, A.S.; Vieira, J.; Florindo, H.F.; Videira, M.A.; Cabral-Marques, H.M.. "Characterisation of DM-ß-cyclodextrin: Prednisolone complexes and their formulation as eye drops". Journal of Inclusion Phenomena and Macrocyclic Chemistry 80 1-2 (2014): 155-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922418658&partnerID=MN8TOARS.
    10.1007/s10847-014-0420-8
  17. Couto, A.R.S.; Cardoso, D.E.; Cabral-Marques, H.M.. "Validation of an HPLC analytical method for the quantitative/qualitative determination of fluticasone propionate in inhalation particles on several matrices". Scientia Pharmaceutica 82 4 (2014): 787-797. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912016964&partnerID=MN8TOARS.
    10.3797/scipharm.1404-11
  18. Ascenso, A.; Salgado, A.; Euletério, C.; Praça, F.G.; Bentley, M.V.L.B.; Marques, H.C.; Oliveira, H.; Santos, C.; Simões, S.. "In vitro and in vivo topical delivery studies of tretinoin-loaded ultradeformable vesicles". European Journal of Pharmaceutics and Biopharmaceutics 88 1 (2014): 48-55. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934282691&partnerID=MN8TOARS.
    10.1016/j.ejpb.2014.05.002
  19. Ascenso, A.; Ribeiro, H.; Marques, H.C.; Oliveira, H.; Santos, C.; Simões, S.. "Chemoprevention of photocarcinogenesis by lycopene". Experimental Dermatology 23 12 (2014): 874-878. http://www.scopus.com/inward/record.url?eid=2-s2.0-84914174838&partnerID=MN8TOARS.
    10.1111/exd.12491
  20. Ascenso, A.; Ribeiro, H.; Marques, H.C.; Oliveira, H.; Santos, C.; Simões, S.. "Is tretinoin still a key agent for photoaging management?". Mini-Reviews in Medicinal Chemistry 14 8 (2014): 629-641. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906907817&partnerID=MN8TOARS.
    10.2174/1389557514666140820102735
  21. Drumond, N.; Couto, A.S.; Costa, A.; Cabral-Marques, H.. "Study of aerodynamic and release properties of inhaled particles containing cyclodextrins". Journal of Inclusion Phenomena and Macrocyclic Chemistry 80 1-2 (2014): 25-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896692586&partnerID=MN8TOARS.
    10.1007/s10847-014-0400-z
  22. Salústio, P.J.; Pinto, J.F.; Costa, P.C.; Cabral-Marques, H.M.. "Release profiles of indometacin in ß-cyclodextrin complexes from HPMC capsules". Journal of Inclusion Phenomena and Macrocyclic Chemistry 75 1-2 (2013): 101-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873919480&partnerID=MN8TOARS.
    10.1007/s10847-012-0151-7
  23. Ascenso, A.; Cruz, M.; Euletério, C.; Carvalho, F.A.; Santos, N.C.; Marques, H.C.; Simões, S.. "Novel tretinoin formulations: A drug-in-cyclodextrin-in-liposome approach". Journal of Liposome Research 23 3 (2013): 211-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880463944&partnerID=MN8TOARS.
    10.3109/08982104.2013.788026
  24. Salústio, P.J.; Feio, G.; Figueirinhas, J.L.; Cabral-Marques, H.M.; Costa, P.C.; Pinto, J.F.. "Release profile of ibuprofen in ß-cyclodextrin complexes from two different solid dosage forms". Powder Technology 221 (2012): 245-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858620569&partnerID=MN8TOARS.
    10.1016/j.powtec.2012.01.008
  25. Ascenso, A.; Vultos, F.; Ferrinho, D.; Salgado, A.; Filho, S.G.; Ferrari, V.; Simões, S.; Marques, H.C.. "Effect of tretinoin inclusion in dimethyl-beta-cyclodextrins on release rate from a hydrogel formulation". Journal of Inclusion Phenomena and Macrocyclic Chemistry 73 1-4 (2012): 459-465. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862621735&partnerID=MN8TOARS.
    10.1007/s10847-011-0002-y
  26. Abreu, S.; Silva, L.F.; Teixeira, S.; Marques, H.C.; Ramalhete, N.; Antunes, H.. "Evaluation of the performance of three spacers | Avaliação do Desempenho de Três Câmaras de Expansão". Acta Medica Portuguesa 25 1 (2012): 4-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865179487&partnerID=MN8TOARS.
  27. Salústio, P.J.; Pontes, P.; Conduto, C.; Sanches, I.; Carvalho, C.; Arrais, J.; Marques, H.M.C.. "Advanced technologies for oral controlled release: Cyclodextrins for oral controlled release". AAPS PharmSciTech 12 4 (2011): 1276-1292. http://www.scopus.com/inward/record.url?eid=2-s2.0-83555176034&partnerID=MN8TOARS.
    10.1208/s12249-011-9690-2
  28. Ascenso, A.; Guedes, R.; Bernardino, R.; Diogo, H.; Carvalho, F.A.; Santos, N.C.; Silva, A.M.; Marques, H.C.. "Complexation and full characterization of the tretinoin and dimethyl-ß-cyclodextrin complex.". AAPS PharmSciTech 12 2 (2011): 553-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027944148&partnerID=MN8TOARS.
  29. Ascenso, A.; Duarte, A.; Silva, A.; Salgado, A.; Marques, H.C.. "Formulation studies on a topical gel of tretinoin-dimethyl-beta- cyclodextrin complex". Journal of Inclusion Phenomena and Macrocyclic Chemistry 69 3-4 (2011): 339-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955949111&partnerID=MN8TOARS.
    10.1007/s10847-010-9745-0
  30. Salústio, P.J.; Cabral-Marques, H.M.; Costa, P.C.; Pinto, J.F.. "Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: ß-Cyclodextrin complex". European Journal of Pharmaceutics and Biopharmaceutics 78 1 (2011): 58-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953163698&partnerID=MN8TOARS.
    10.1016/j.ejpb.2010.12.022
  31. Ascenso, A.; Guedes, R.; Bernardino, R.; Diogo, H.; Carvalho, F.A.; Santos, N.C.; Silva, A.M.; Marques, H.C.. "Complexation and Full Characterization of the Tretinoin and Dimethyl-ßeta-Cyclodextrin Complex". AAPS PharmSciTech (2011): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955141022&partnerID=MN8TOARS.
    10.1208/s12249-011-9612-3
  32. Ascenso, A.; Guedes, R.; Bernardino, R.; Diogo, H.; Carvalho, F.A.; Santos, N.C.; Silva, A.M.; Marques, H.C.. "Complexation and full characterization of the tretinoin and dimethyl-ß-cyclodextrin complex.". AAPS PharmSciTech 12 2 (2011): 553-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861168025&partnerID=MN8TOARS.
  33. Ramos, M.; Salústio, P.; Serralheiro, L.; Fazão, F.; Marques, H.. "Stability and enzymatic studies with omeprazole: Hydroxypropyl-ß- cyclodextrin". Journal of Inclusion Phenomena and Macrocyclic Chemistry 70 3-4 (2011): 407-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051793910&partnerID=MN8TOARS.
    10.1007/s10847-010-9884-3
  34. Almeida, H.M.; Cabral Marques, H.M.. "Physicochemical characterization of finasteride: PEG 6000 and finasteride: Kollidon K25 solid dispersions, and finasteride: ß-cyclodextrin inclusion complexes". Journal of Inclusion Phenomena and Macrocyclic Chemistry 70 3-4 (2011): 397-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051784219&partnerID=MN8TOARS.
    10.1007/s10847-010-9898-x
  35. Ascenso, A.; Ribeiro, H.M.; Marques, H.C.; Simões, S.. "Topical delivery of antioxidants". Current Drug Delivery 8 6 (2011): 640-660. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054119415&partnerID=MN8TOARS.
    10.2174/156720111797635487
  36. Marques, H.M.C.. "A review on cyclodextrin encapsulation of essential oils and volatiles". Flavour and Fragrance Journal 25 5 (2010): 313-326. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651512113&partnerID=MN8TOARS.
    10.1002/ffj.2019
  37. Marques, Helena. "Optimisation of spray-drying variables for DPI formulation.". Eur. J. Pharm. Biopharm. 73, 121–129. (2009):
    doi: 10.1016/j.ejpb.2009.05.002.
  38. Salústio, P.J.; Feio, G.; Figueirinhas, J.L.; Pinto, J.F.; Cabral Marques, H.M.. "The influence of the preparation methods on the inclusion of model drugs in a ß-cyclodextrin cavity". European Journal of Pharmaceutics and Biopharmaceutics 71 2 (2009): 377-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649105647&partnerID=MN8TOARS.
    10.1016/j.ejpb.2008.09.027
  39. Ascenso, A.; Marques, H.C.. "Acne in the adult". Mini-Reviews in Medicinal Chemistry 9 1 (2009): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-62749120323&partnerID=MN8TOARS.
    10.2174/138955709787001730
  40. Cabral-Marques, H.; Almeida, R.. "Optimisation of spray-drying process variables for dry powder inhalation (DPI) formulations of corticosteroid/cyclodextrin inclusion complexes". European Journal of Pharmaceutics and Biopharmaceutics 73 1 (2009): 121-129. http://www.scopus.com/inward/record.url?eid=2-s2.0-68349139720&partnerID=MN8TOARS.
    10.1016/j.ejpb.2009.05.002
  41. Abreu, S.; Silva, L.; Teixeira, S.F.C.F.; Antunes, H.; Marques, H.; Ramalhete, N.. "Experimental study and CFD analysis of the volumatic® spacer". 2008 Proceedings of the 3rd Frontiers in Biomedical Devices Conference and Exhibition (2008): 97-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349138874&partnerID=MN8TOARS.
  42. Ferreira, Q.; Coelhoso, I.M.; Ramalhete, N.; Marques, H.M.C.. "Resolution of racemic propranolol in liquid membranes containing TA-ß-cyclodextrin". Separation Science and Technology 41 16 (2006): 3553-3568. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845511816&partnerID=MN8TOARS.
    10.1080/01496390600997799
  43. Waleczek, K.J.; Cabral Marques, H.M.; Hempel, B.; Schmidt, P.C.. "Phase solubility studies of pure (-)-a-bisabolol and camomile essential oil with ß-cyclodextrin". European Journal of Pharmaceutics and Biopharmaceutics 55 2 (2003): 247-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037333948&partnerID=MN8TOARS.
    10.1016/S0939-6411(02)00166-2
  44. Junco, S.; Casimiro, T.; Ribeiro, N.; Nunes Da Ponte, M.; Cabral Marques, H.M.. "Optimisation of supercritical carbon dioxide systems for complexation of naproxen: Beta-cyclodextrin". Journal of Inclusion Phenomena 44 1-4 (2002): 69-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346396111&partnerID=MN8TOARS.
    10.1023/A:1023028815180
  45. Vozone, C.M.; Cabral Marques, H.M.. "Complexation of budesonide in cyclodextrins and particle aerodynamic characterization of the complex solid form for dry powder inhalation". Journal of Inclusion Phenomena 44 1-4 (2002): 111-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347026148&partnerID=MN8TOARS.
    10.1023/A:1023069924266
  46. Junco, S.; Casimiro, T.; Ribeiro, N.; Nunes Da Ponte, M.; Cabral Marques, H.. "A comparative study of naproxen - Beta cyclodextrin complexes prepared by conventional methods and using supercritical carbon dioxide". Journal of Inclusion Phenomena 44 1-4 (2002): 117-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346396082&partnerID=MN8TOARS.
    10.1023/A:1023022008337
  47. Cabral Marques, H.M.; Schmidt, P.C.. "In vitro deposition of the respirable fraction of dry powder inhalations determined by laser diffractometry and inertial impaction". Pharmazie 57 8 (2002): 546-551. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036673909&partnerID=MN8TOARS.
  48. Póvoa, L.; Cabral Marques, H.. "Cyclodextrins and cosmetics | Ciclodextrinas e cosmética". Revista Portuguesa de Farmacia 51 3 (2001): 139-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035670373&partnerID=MN8TOARS.
  49. Cabral Marques, H.M.; Orth, H.; Schmidt, P.C.. "Simultaneous determination of lactose and sodium cromoglycate in a dry powder inhalation formulation". Pharmazie 54 10 (1999): 785-786. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032834045&partnerID=MN8TOARS.
  50. Leite Pinto, J.M.C.; Cabral Marques, H.M.. "Beclomethasone/cyclodextrin inclusion complex for dry powder inhalation". S.T.P. Pharma Sciences 9 3 (1999): 253-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345535636&partnerID=MN8TOARS.
  51. Paulo, M.G.; Cabral Marques, H.M.; Morais, J.A.G.; Almeida, A.J.. "An isocratic LC method for the simultaneous determination of vitamins A, C, E and ß-carotene". Journal of Pharmaceutical and Biomedical Analysis 21 2 (1999): 399-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032716801&partnerID=MN8TOARS.
    10.1016/S0731-7085(99)00172-7
  52. Cabral Marques, H.M.. "Applications of cyclodextrins. Thermodynamic aspects of cyclodextrin complexes". Revista Portuguesa de Farmacia 44 2 (1994): 85-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028298746&partnerID=MN8TOARS.
  53. Cabral Marques, H.M.. "Structure and properties of cyclodextrins. Inclusion complex formation". Revista Portuguesa de Farmacia 44 2 (1994): 77-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028283729&partnerID=MN8TOARS.
  54. Cabral Marques, H.M.. "Cyclodextrins' derivatives. Absorption, toxicity, metabolism and fate". Revista Portuguesa de Farmacia 44 4 (1994): 147-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028577176&partnerID=MN8TOARS.
  55. Cabral Marques, H.M.; Hadgraft, J.; Kellaway, I.W.; Taylor, G.. "Studies of cyclodextrin inclusion complexes. III. The pulmonary absorption of ß-, DM-ß- and HP-ß-cyclodextrins in rabbits". International Journal of Pharmaceutics 77 2-3 (1991): 297-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026041229&partnerID=MN8TOARS.
  56. Cabral Marques, H.M.; Hadgraft, J.; Kellaway, I.W.; Taylor, G.. "Studies of cyclodextrin inclusion complexes. IV. The pulmonary absorption of salbutamol from a complex with 2-hydroxypropyl-ß-cyclodextrin in rabbits". International Journal of Pharmaceutics 77 2-3 (1991): 303-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025987104&partnerID=MN8TOARS.
  57. Cabral Marques, H.M.; Hadgraft, J.; Kellaway, I.W.; Taylor, G.. "The absorption of salbutamol (SA) from the rabbit lung following intratracheal instillation of salbutamol complexed with 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CYD)". Journal of Pharmacy and Pharmacology, Supplement 43 (1991): http://www.scopus.com/inward/record.url?eid=2-s2.0-0025983718&partnerID=MN8TOARS.
  58. Cabral Marques, H.M.; Morais, J.A.. "Cyclodextrine inclusion compounds | CICLODEXTRINAS E SEUS COMPLEXOS DE INCLUSAO". Revista Portuguesa de Farmacia 41 2 (1991): 5-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025812112&partnerID=MN8TOARS.
  59. Cabral Marques, H.M.; Hadgraft, J.; Kellaway, I.W.; Taylor, G.. "Studies of cyclodextrin inclusion complexes. III. The pulmonary absorption of ß-, DM-ß- and HP-ß-cyclodextrins in rabbits". International Journal of Pharmaceutics 77 2-3 (1991): 297-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026041229&partnerID=MN8TOARS.
    10.1016/0378-5173(91)90330-Q
  60. Cabral Marques, H.M.; Hadgraft, J.; Kellaway, I.W.; Taylor, G.. "Studies of cyclodextrin inclusion complexes. IV. The pulmonary absorption of salbutamol from a complex with 2-hydroxypropyl-ß-cyclodextrin in rabbits". International Journal of Pharmaceutics 77 2-3 (1991): 303-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025987104&partnerID=MN8TOARS.
    10.1016/0378-5173(91)90331-H
  61. Marques, H.M.C.; Hadgraft, J.; Kellaway, I.W.; Pugh, W.J.. "Studies of cyclodextrin inclusion complexes. II. Molecular modelling and1H-NMR evidence for the salbutamol-ß-cyclodextrin complex". International Journal of Pharmaceutics 63 3 (1990): 267-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025223244&partnerID=MN8TOARS.
    10.1016/0378-5173(90)90133-O
  62. Cabral-Marques, H.M.; Hadgraft, J.; Taylor, G.; Brain, K.R.; Kellaway, I.W.; Williams, A.; Farr, S.J.. "THE ABSORPTION OF ß-, DM-ß- AND HP-ß-CYCLODEXTRINS FROM THE RABBIT LUNG". Journal of Pharmacy and Pharmacology 42 1 S (1990): 13P-13P. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988147334&partnerID=MN8TOARS.
    10.1111/j.2042-7158.1990.tb14386.x
  63. Marques, H.M.C.; Hadgraft, J.; Kellaway, I.W.. "Studies of cyclodextrin inclusion complexes. I. The salbutamol-cyclodextrin complex as studied by phase solubility and DSC". International Journal of Pharmaceutics 63 3 (1990): 259-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025258947&partnerID=MN8TOARS.
  64. Cabral Marques, H.M.; Hadgraft, J.; Kellaway, I.W.. "Studies of cyclodextrin inclusion complexes. I. The salbutamol-cyclodextrin complex as studied by phase solubility and DSC". International Journal of Pharmaceutics 63 3 (1990): 259-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025258947&partnerID=MN8TOARS.
    10.1016/0378-5173(90)90132-N
  65. Cabral-Marques, H.M.; Hadgraft, J.; Taylor, G.; Brain, K.R.; Kellaway, I.W.; Williams, A.; Farr, S.J.. "The absorption of ß-, DM-ß- and HP-ß-cyclodextrins from the rabbit lung". Journal of Pharmacy and Pharmacology, Supplement 42 (1990): http://www.scopus.com/inward/record.url?eid=2-s2.0-18144446205&partnerID=MN8TOARS.
  66. Cabral Marques, H.M.; Pugh, W.J.; Hadgraft, J.; Kellaway, I.W.. "The ß-cyclodextrin-salbutamol complex". Journal of Pharmacy and Pharmacology, Supplement 41 (1989): http://www.scopus.com/inward/record.url?eid=2-s2.0-0024955778&partnerID=MN8TOARS.
Livro
  1. Sá Couto, A.; Salústio, P.; Cabral-Marques, H.. Cyclodextrins. 2015.
    10.1007/978-3-319-16298-0_22
Relatório
  1. Pereira,Anabela; Albuquerque, Carlos; Carrilho, Eunice; Marques, Helena Cabral; Rosas, Manuel; Matos, Margarida Gaspar de; Oliveira, Maria; et al. 2017. Competências profissionais no âmbito da prevenção e do tratamento do tabagismo no final da formação pré-graduada dos profissionais de saúde. http://hdl.handle.net/10773/21726.
Tese / Dissertação
  1. Correia, Ricardo Jorge Rato. "Visualização e análise de dados no desenvolvimento e implementação de sistemas de gestão de qualidade e de risco". Mestrado, 2015. http://hdl.handle.net/10451/28875.

Propriedade Intelectual

Marca registada
  1. 2013. "Design of a nose-only-chamber, for several animals simultaneously, promoting the targeted pulmonary administration of dry powder formulations".
    Registada
Patente
  1. Goucha Jorge, P.S. ; Cabral Marques, H.M.. 1996. "Complexes of vinpocetine formed with cyclodextrins, process for their preparation and pharmaceutical compositions containing them.".
    Retirada
  2. Torres Marques, M.; Baptista, A.M.J.; Cabral Marques, H.M.; Chitas, I.J. ; Rodrigues de Carvalho, M.. 1986. "Método para aumentar a solubilidade e a estabilidade do cloranfenicol, através da formação de complexos de inclusão com ciclodextrinas, soluções contendo o referido complexo de inclusão e processo para separação dessas soluções". Portugal.
    Expirada

Outros

Outra produção
  1. Release profile of ibuprofen in ß-cyclodextrin complexes from two different solid dosage forms. The objective of this work was to develop solid dosage forms using powders containing inclusion complexes (ibuprofen with ß-cyclodextrin) which were used to produce tablets (direct compression without additional excipients) and pellets (extrusion/spheronization) from wet mass containing 40% (w/w) of microcrystalline cellulose. The pellets also demonstrated that during preparation of the wet mass,. 2012. Salústio, Paulo; Feio, Gabriel; Figueirinhas, João; Cabral-Marques, Helena; Costa, Paulo; Pinto, João. http://dx.doi.org/10.1016/j.powtec.2012.01.008.
    http://dx.doi.org/10.1016/j.powtec.2012.01.008
  2. Complexation and full characterization of the tretinoin and dimethyl-ßeta-cyclodextrin complex. Abstract. The aim of this work is to prepare tretinoin/dimethyl-beta-cyclodextrin complexes and fully characterize them through various analytical techniques. According to the phase solubility studies performed, the equilibrium for maximum complexation is reached in about 8 days presenting an AL-type diagram (soluble complexes) corresponding mainly to 1:1 stoichiometry (Ks=13,600 M-1), although th. 2011. Ascenso, Andreia; Guedes, Rita; Bernardino, Raul; Diogo, Herminio; Carvalho, Filomena A.; Santos, Nuno C.; Silva, Aida M.; Marques, Helena Cabral. http://dx.doi.org/10.1208/s12249-011-9612-.
    http://dx.doi.org/10.1208/s12249-011-9612-
  3. Formulation studies on a topical gel of tretinoin-dimethyl-beta-cyclodextrin complex. The aim of this work was to develop and characterize a 0.05% tretinoin hydrogel formulations in which tretinoin is free or complexed with dimethyl-beta-cyclodextrin in order to compare the main advantages of its complexation. Theoretically, the complexati. 2011. Ascenso, Andreia; Duarte, Aida; Silva, Alexandra; Salgado, Ana; Marques, Helena Cabral. http://hdl.handle.net/10451/21700.
    http://dx.doi.org/10.1007/s10847-010-9745-0
  4. Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release. Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent gastrointestinal side effects and unpleasant smell or taste, to prevent drug-drug o. 2011. Salústio, Paulo José; Pontes, Patrícia; Conduto, Cláudia; Sanches, Inês; Carvalho, Catarina; Arrais, João; Cabral Marques, Helena M. http://dx.doi.org/10.1208/s12249-011-9690-2.
    http://dx.doi.org/10.1208/s12249-011-9690-2
  5. Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: ß-Cyclodextrin complex. Mixtures containing ibuprofen (IB) complexed with b-cyclodextrin (bCD) obtained by two complexation methods [suspension/solution (with water removed by air stream, spray- and freeze-drying) and kneading technique] were processed into pharmaceutical dosage forms (minitablets and capsules). Powders (IB, bCD and IBbCD) were characterized for moisture content, densities (true and bulk), angle of repos. 2010. Salústio, Paulo; Marques, Helena Cabral; Costa, Paulo; Pinto, João. http://dx.doi.org/10.1016/j.ejpb.2010.12.022.
    http://dx.doi.org/10.1016/j.ejpb.2010.12.022
  6. The influence of the preparation methods on the inclusion of model drugs in a ß-cyclodextrin cavity. The work aims to prove the complexation of two model drugs (ibuprofen, IB and indomethacin, IN) by bcyclodextrin (bCD), and the effect of water in such a process, and makes a comparison of their complexation yields. Two methods were considered: kneading of a binary mixture of the drug, bCD, and inclusion of either IB or IN in aqueous solutions of bCD. In the latter method water was removed by air. 2008. Salústio, Paulo; Feio, Gabriel; Figueirinhas, João; Pinto, João; Marques, Helena Cabral. http://hdl.handle.net/10451/3805.
    http://dx.doi.org/10.1016/j.ejpb.2008.09.027
  7. Improvement of organoleptic properties of thymol and carvacrol using ß-cyclodextrin. 2008. Daletos, George; Papaioannou, Georgia; Miguel, Graça; Marques, Helena Cabral. http://hdl.handle.net/10451/21972.
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2015 - 2019/11/11 Cyclodextrin supramolecular systems for oral antiretroviral drug delivery
Orientador
Farmácia (Outra)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2015/07/17 Visualização e análise de dados no desenvolvimento e implementação de sistemas de gestão de qualidade e de risco
Coorientador
Engenharia Farmacêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2003 - 2003 Promoção do Aumento da Solubilidade de Farmacos Pouco Solúveis para a Sua Administração Oral em Formas Farmacêuticas de Libertação Imediata Ou Controlada
Orientador
Farmácia (Doutoramento)
Universidade de Lisboa, Portugal
Distinções

Outra distinção

2013 Industrial Pharmacy Award 2013 for the best Industrial Pharmacy contribution by a Young Pharmacist/Scientist
International Pharmaceutical Federation, Países Baixos