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PhD research: I received my PhD in 2008 from Minho University where I studied choroid plexus (CP), a brain immune barrier. During that period, I found that CP acts as a sensor of peripheral inflammation. So, I wanted to know what happens to CP when inflammation is coming from the brain, rather than from the periphery. To answer that question, I went to Aloisi¿s lab at Sapienza University, Italy. There, I studied Multiple Sclerosis (MS) in mice, a model of brain inflammation. Post-doctoral research: Based on the experience gained from my PhD I decided to deepen my studies on MS. During that stage I started incorporating new techniques and briefly moved to Brazil to learn genomic bioinformatics tools at Brentani¿s lab, São Paulo University. The results of this and other collaborative project with Dr. Coppola at UCLA University, USA, catalysed several novel findings in MS. Most importantly, I found that lipocalin 2 (LCN2), a protein from my PhD, known to be altered in peripheral inflammation, is also altered in MS mice, a non-peripheral brain inflammation model. Assistant researcher: In 2013, I successfully acquired funding from the Portuguese Science Foundation (FCT) to study LCN2 and to establish myself as an Assistant researcher. With the addition of several MSc and PhD students, my portfolio has expanded to a wide array of projects focused around two main research themes: (i) role of LCN2 in physiological conditions and (ii) in pathological conditions such as MS and Alzheimer¿s disease (AD). Principal Investigator: In 2018, starting in 2019, I successfully acquired funding from the Portuguese Science Foundation (FCT) to study Multiple Sclerosis (MS) and to establish a MS Biobank. Stemming from the hypothesis that perpetuation of brain inflammation by local glia is leading to neurodegeneration even when there is no brain immune cell infiltration from the periphery, it is our aim to: 1) Perform basic translational experiments to answer the question if decreasing glia mediated inflammation is able to influence MS outcomes in a mouse model of disease; 2) Perform clinical translational experiments to answer the question if previous findings from mouse models are also implicated in the human disease. Besides ongoing experiments directed to continue the studies in LCN2, and further extend these studies to other astrocytic and microglia markers, we are now partnering with Braga Hospital, starting the consolidation of a biobank of MS patients. Along my scientific path I have contributed to 5 book chapters, 53 publications in international peer reviewed journals (26 in the last 5 years; 5 as last author), 2369 citations and an h-index of 33 (Scopus indicators). I supervised 4 PhD students (currently one is an established professor at Florida University and the other are Post-docs at: Sandro´s lab, Florida University, USA; Castellano’s Lab, Mount Sinai, USA and International Iberian Nanotechnology Lab, Portugal), and 7 Master students. Since 2009, I am also an invited Assistant Professor at School of Medicine of the medical degree in the UMinho.
Identificação

Identificação pessoal

Nome completo
Fernanda Cristina Gomes de Sousa Marques

Nomes de citação

  • Marques, Fernanda

Identificadores de autor

Ciência ID
DA19-F2F3-8E3F
ORCID iD
0000-0002-3612-1870
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=A0nIDFgAAAAJ
Researcher Id
D-4238-2012
Scopus Author Id
8449898700

Telefones

Telefone
  • 253604997 (Profissional)

Moradas

  • Life and Health Sciences Research Institute (ICVS), Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Formação
Grau Classificação
2008/06/01 - 2013/12/30
Concluído
The involvement of the choroid plexus in neurological diseases (Pós-doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2004/05/01 - 2008/05/15
Concluído
PhD Thesis in Health sciences - Biological and Biomedical Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"The choroid plexus as a sensor of peripheral inflammation" (TESE/DISSERTAÇÃO)
1997/09/01 - 2001/10/10
Concluído
Applied Biology (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/05/01 - 2025/04/30 Investigador principal (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/01/01 - 2018/12/31 Assistente de Investigação (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003/01/01 - 2003/12/31 Assistente de Investigação (carreira) (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/10/01 - 2002/12/31 Assistente de Investigação (carreira) (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2009/12/31 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade do Minho Escola de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2008/07/01 - 2013/12/31 Post-Doctoral Fellowship Assistant Professor Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008/08/01 - 2008/10/31 Visiting Scientist. Genomic bioinformatics tools. Under the supervision of Dr. Helena Brentani Hospital do Câncer I, Brasil
2004/02/01 - 2008/05/15 PhD student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007/04/01 - 2007/06/30 Visiting Scientist. Multiple Sclerosis animal models. Under the supervision of Francesca Aloisi. Istituto Superiore di Sanità, Itália
Projetos

Bolsa

Designação Financiadores
2020/02/15 - 2021/02/14 Patch-seq analysis of the choroid plexus epithelial cell barrier in homeostasis and in Alzheimer’s disease
2019 BBEE: Marquez
Outra
Universidade do Minho Escola de Medicina, Portugal
Cure Alzheimer's Fund
Em curso
2017/09/01 - 2018/08/31 Exploring astrocytic proteins as novel biomarkers of Multiple Sclerosis
EXPL/001/2016
Outra
Universidade do Minho Escola de Medicina, Portugal
Clinic Academic Center, 2CA
Concluído
2013/05 - 2016/05 Adaptive and maladaptive response to stress: longitudinal characterization in brain imaging and molecular correlates Fundação para a Ciência e a Tecnologia, I.P.
2014/03 - 2015/02 Multiple Sclerosis: Studying lipocalin 2 as a novel player in the pathophysiology of the disease. Fundação para a Ciência e a Tecnologia, I.P.
2009/04 - 2013/03 New approaches in multiple sclerosis diagnosis: the role of the choroid plexus. Fundação para a Ciência e a Tecnologia, I.P.
2010/05 - 2012/05 Neudesina - estudo da função de um novo factor neurotrófico Fundação para a Ciência e a Tecnologia, I.P.
2005/08 - 2008/07 The role of choroid plexus proteins in brain inflammation Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2019/05/01 - 2025/04/30 Biology and Physiology of Multiple Sclerosis
CEECIND/01084/2017
Outra
Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2013/12/31 - 2018/12/30 Brain barriers: modulating iron availability to target diseases of the CNS
IF/00231/2013
Outra
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Ana Bela Campos; Sara Duarte-Silva; Bruno Fernandes; Sofia Pereira das Neves; Fernanda Marques; Andreia Teixeira-Castro; Andreia Neves-Carvalho; et al. "Profiling Microglia in a Mouse Model of Machado–Joseph Disease". Biomedicines 10 2 (2022): 237-237. https://doi.org/10.3390/biomedicines10020237.
    10.3390/biomedicines10020237
  2. Ana Tahira; Fernanda Marques; Bianca Lisboa; Arthur Feltrin; André Barbosa; Kátia Cristina de Oliveira; Carlos Alberto de Bragança Pereira; et al. "Are the 50’s, the transition decade, in choroid plexus aging?". GeroScience (2021): https://doi.org/10.1007/s11357-021-00329-x.
    10.1007/s11357-021-00329-x
  3. Sofia Pereira Neves; João Carlos Sousa; Nuno Sousa; João José Cerqueira; Fernanda Marques. "Altered astrocytic function in experimental neuroinflammation and multiple sclerosis". Glia (2020): https://doi.org/10.1002/glia.23940.
    10.1002/glia.23940
  4. Santos, C.R.A.; Duarte, A.C.; Quintela, T.; Tomás, J.; Albuquerque, T.; Marques, F.; Palha, J.A.; Gonçalves, I.. "The choroid plexus as a sex hormone target: Functional implications". Frontiers in Neuroendocrinology 44 (2017): 103-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008324860&partnerID=MN8TOARS.
    10.1016/j.yfrne.2016.12.002
  5. Jacinto, L.R.; Mata, R.; Novais, A.; Marques, F.; Sousa, N.. "The habenula as a critical node in chronic stress-related anxiety". Experimental Neurology 289 (2017): 46-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007248603&partnerID=MN8TOARS.
    10.1016/j.expneurol.2016.12.003
  6. Marques, F.; Sousa, J.C.; Brito, M.A.; Pahnke, J.; Santos, C.; Correia-Neves, M.; Palha, J.A.. "The choroid plexus in health and in disease: dialogues into and out of the brain". Neurobiology of Disease 107 (2017): 32-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995495545&partnerID=MN8TOARS.
    10.1016/j.nbd.2016.08.011
  7. Tavares, G.; Martins, M.; Correia, J.S.; Sardinha, V.M.; Guerra-Gomes, S.; das Neves, S.P.; Marques, F.; Sousa, N.; Oliveira, J.F.. "Employing an open-source tool to assess astrocyte tridimensional structure". Brain Structure and Function 222 4 (2017): 1989-1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989199342&partnerID=MN8TOARS.
    10.1007/s00429-016-1316-8
  8. Taipa, R.; Ferreira, V.; Brochado, P.; Robinson, A.; Reis, I.; Marques, F.; Mann, D.M.; Melo-Pires, M.; Sousa, N.. "Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: A post mortem study". Neuropathology and Applied Neurobiology (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85035245846&partnerID=MN8TOARS.
    10.1111/nan.12445
  9. Monteiro, S.; Roque, S.; Marques, F.; Correia-Neves, M.; Cerqueira, J.J.. "Brain interference: Revisiting the role of IFN¿ in the central nervous system". Progress in Neurobiology 156 (2017): 149-163. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020204542&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2017.05.003
  10. Pereira, V.H.; Marques, F.; Lages, V.; Pereira, F.G.; Patchev, A.; Almeida, O.F.X.; Almeida-Palha, J.; Sousa, N.; Cerqueira, J.J.. "Glucose intolerance after chronic stress is related with downregulated PPAR-¿ in adipose tissue". Cardiovascular Diabetology 15 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84982216636&partnerID=MN8TOARS.
    10.1186/s12933-016-0433-2
  11. Teixeira, F.G.; Vasconcelos, N.L.; Gomes, E.D.; Marques, F.; Sousa, J.C.; Sousa, N.; Silva, N.A.; et al. "Bioengineered cell culture systems of central nervous system injury and disease". Drug Discovery Today 21 9 (2016): 1456-1463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975780622&partnerID=MN8TOARS.
    10.1016/j.drudis.2016.04.020
  12. Pires, L.R.; Marques, F.; Sousa, J.C.; Cerqueira, J.; Pinto, I.M.. "Nano- and micro-based systems for immunotolerance induction in multiple sclerosis". Human Vaccines and Immunotherapeutics 12 7 (2016): 1886-1890. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963511160&partnerID=MN8TOARS.
    10.1080/21645515.2016.1138190
  13. Dá Mesquita, S.; Ferreira, A.C.; Sousa, J.C.; Correia-Neves, M.; Sousa, N.; Marques, F.. "Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system". Neuroscience and Biobehavioral Reviews 68 (2016): 547-562. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978997730&partnerID=MN8TOARS.
    10.1016/j.neubiorev.2016.06.014
  14. Mesquita, S.D.; Ferreira, A.C.; Gao, F.; Coppola, G.; Geschwind, D.H.; Sousa, J.C.; Correia-Neves, M.; et al. "The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease". Brain, Behavior, and Immunity (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84931299923&partnerID=MN8TOARS.
    10.1016/j.bbi.2015.06.008
  15. Oliveira, T.G.; Chan, R.B.; Bravo, F.V.; Miranda, A.; Silva, R.R.; Zhou, B.; Marques, F.; et al. "The impact of chronic stress on the rat brain lipidome". Molecular Psychiatry (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924347440&partnerID=MN8TOARS.
    10.1038/mp.2015.14
  16. Marques, F.; Sousa, J.C.. "The choroid plexus is modulated by various peripheral stimuli: Implications to diseases of the central nervous system". Frontiers in Cellular Neuroscience 9 APR (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927586383&partnerID=MN8TOARS.
    10.3389/fncel.2015.00136
  17. Morgado, P.; Marques, F.; Ribeiro, B.; Leite-Almeida, H.; Pêgo, J.M.; Rodrigues, A.J.; Dalla, C.; et al. "Stress induced risk-aversion is reverted by D2/D3 agonist in the rat". European Neuropsychopharmacology 25 10 (2015): 1744-1752. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943360838&partnerID=MN8TOARS.
    10.1016/j.euroneuro.2015.07.003
  18. Ferreira, A.C.; Dá Mesquita, S.; Sousa, J.C.; Correia-Neves, M.; Sousa, N.; Palha, J.A.; Marques, F.. "From the periphery to the brain: Lipocalin-2, a friend or foe?". Progress in Neurobiology 131 (2015): 120-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938060147&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2015.06.005
  19. Aslani, S.; Vieira, N.; Marques, F.; Costa, P.S.; Sousa, N.; Palha, J.A.. "The effect of high-fat diet on rat's mood, feeding behavior and response to stress". Translational Psychiatry 5 11 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84989965263&partnerID=MN8TOARS.
    10.1038/tp.2015.178
  20. Mesquita, S.D.; Ferreira, A.C.; Falcao, A.M.; Sousa, J.C.; Oliveira, T.G.; Correia-Neves, M.; Sousa, N.; Marques, F.; Palha, J.A.. "Lipocalin 2 modulates the cellular response to amyloid beta". Cell death and differentiation 21 10 (2014): 1588-1599. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930511289&partnerID=MN8TOARS.
    10.1038/cdd.2014.68
  21. Morgado, P.; Marques, F.; Silva, M.B.; Sousa, N.; Cerqueira, J.J.. "A novel risk-based decision-making paradigm". Frontiers in Behavioral Neuroscience 8 FEB (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84894030930&partnerID=MN8TOARS.
    10.3389/fnbeh.2014.00045
  22. Lima, A.; Sardinha, V.M.; Oliveira, A.F.; Reis, M.; Mota, C.; Silva, M.A.; Marques, F.; et al. "Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats". Molecular Psychiatry 19 7 (2014): 834-841. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903591506&partnerID=MN8TOARS.
    10.1038/mp.2013.182
  23. Soares, J.M.; Sampaio, A.; Ferreira, L.M.; Santos, N.C.; Marques, P.; Marques, F.; Palha, J.A.; Cerqueira, J.J.; Sousa, N.. "Stress Impact on Resting State Brain Networks". PLoS ONE 8 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879228947&partnerID=MN8TOARS.
    10.1371/journal.pone.0066500
  24. Novais, A.; Ferreira, A.C.; Marques, F.; Pêgo, J.M.; Cerqueira, J.J.; David-Pereira, A.; Campos, F.L.; et al. "Neudesin is involved in anxiety behavior: Structural and neurochemical correlates". Frontiers in Behavioral Neuroscience SEP (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884698302&partnerID=MN8TOARS.
    10.3389/fnbeh.2013.00119
  25. Bessa, J.M.; Morais, M.; Marques, F.; Pinto, L.; Palha, J.A.; Almeida, O.F.X.; Sousa, N.. "Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens". Translational Psychiatry 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879969155&partnerID=MN8TOARS.
    10.1038/tp.2013.39
  26. Marques, F.; Sousa, J.C.; Sousa, N.; Palha, J.A.. "Blood-brain-barriers in aging and in Alzheimer's disease". Molecular Neurodegeneration 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886907892&partnerID=MN8TOARS.
    10.1186/1750-1326-8-38
  27. Ferreira, A.C.; Pinto, V.; Dá Mesquita, S.; Novais, A.; Sousa, J.C.; Correia-Neves, M.; Sousa, N.; Palha, J.A.; Marques, F.. "Lipocalin-2 is involved in emotional behaviors and cognitive function". Frontiers in Cellular Neuroscience JUL (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880139680&partnerID=MN8TOARS.
    10.3389/fncel.2013.00122
  28. Marques, F.; Rodrigues, A.-J.; Sousa, J.C.; Coppola, G.; Geschwind, D.H.; Sousa, N.; Correia-Neves, M.; Palha, J.A.. "Erratum: Lipocalin 2 is a choroid plexus acute-phase protein (Journal of Cerebral Blood Flow and Metabolism (2008) 28 (450-455) DOI: 10.1038/sj.jcbfm. 9600557)". Journal of Cerebral Blood Flow and Metabolism 33 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874590597&partnerID=MN8TOARS.
    10.1038/jcbfm.2012.170
  29. Soares, J.M.; Sampaio, A.; Marques, P.; Ferreira, L.M.; Santos, N.C.; Marques, F.; Palha, J.A.; Cerqueira, J.J.; Sousa, N.. "Plasticity of resting state brain networks in recovery from stress". Frontiers in Human Neuroscience 7 DEC (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891644810&partnerID=MN8TOARS.
    10.3389/fnhum.2013.00919
  30. Ventura-Silva, A.P.; Pêgo, J.M.; Sousa, J.C.; Marques, A.R.; Rodrigues, A.J.; Marques, F.; Cerqueira, J.J.; Almeida, O.F.X.; Sousa, N.. "Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode". European Journal of Neuroscience 36 10 (2012): 3396-3406. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869884316&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2012.08262.x
  31. Mesquita, S.D.; Ferreira, A.C.; Sousa, J.C.; Santos, N.C.; Correia-Neves, M.; Sousa, N.; Palha, J.A.; Marques, F.. "Modulation of iron metabolism in aging and in Alzheimer's disease: Relevance of the choroid plexus". Frontiers in Cellular Neuroscience MAY 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863994297&partnerID=MN8TOARS.
    10.3389/fncel.2012.00025
  32. Soares, J.M.; Sampaio, A.; Ferreira, L.M.; Santos, N.C.; Marques, F.; Palha, J.A.; Cerqueira, J.J.; Sousa, N.. "Stress-induced changes in human decision-making are reversible". Translational Psychiatry 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863738913&partnerID=MN8TOARS.
    10.1038/tp.2012.59
  33. Falcão, A.M.; Palha, J.A.; Ferreira, A.C.; Marques, F.; Sousa, N.; Sousa, J.C.. "Topographical analysis of the subependymal zone neurogenic niche". PLoS ONE 7 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862654912&partnerID=MN8TOARS.
    10.1371/journal.pone.0038647
  34. Falcão, Ana Mendanha; Marques, Fernanda; Novais, Ashley; Sousa, Nuno; Palha, Joana Almeida; Sousa, Joao Carlos. "The path from the choroid plexus to the subventricular zone: go with the flow!". Frontiers in Cellular Neuroscience 6 (2012): http://dx.doi.org/10.3389/fncel.2012.00034.
    10.3389/fncel.2012.00034
  35. Palha, Joana A.; Santos, Nadine C.; Marques, Fernanda; Sousa, João; Bessa, João; Miguelote, Rui; Sousa, Nuno; Belmonte-de-Abreu, Paulo. "Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia". Frontiers in Cellular Neuroscience 6 (2012): http://dx.doi.org/10.3389/fncel.2012.00031.
    10.3389/fncel.2012.00031
  36. Marques, Fernanda; Mesquita, Sandro D.; Sousa, João C.; Coppola, Giovanni; Gao, Fuying; Geschwind, Daniel H.; Columba-Cabezas, Sandra; et al. "Lipocalin 2 is present in the EAE brain and is modulated by natalizumab". Frontiers in Cellular Neuroscience 6 (2012): http://dx.doi.org/10.3389/fncel.2012.00033.
    10.3389/fncel.2012.00033
  37. Marques, F.; Sousa, J.C.; Coppola, G.; Gao, F.; Puga, R.; Brentani, H.; Geschwind, D.H.; et al. "Transcriptome signature of the adult mouse choroid plexus". Fluids and Barriers of the CNS 8 1 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80051724911&partnerID=MN8TOARS.
    10.1186/2045-8118-8-10
  38. Pereira, V.H.; Salgado, A.J.; Oliveira, J.M.; Cerqueira, S.R.; Frias, A.M.; Fraga, J.S.; Roque, S.; et al. "In vivo biodistribution of carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles in rats". Journal of Bioactive and Compatible Polymers 26 6 (2011): 619-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-81555220089&partnerID=MN8TOARS.
    10.1177/0883911511425567
  39. Santos, M.; Summavielle, T.; Teixeira-Castro, A.; Silva-Fernandes, A.; Duarte-Silva, S.; Marques, F.; Martins, L.; et al. "Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome". Neuroscience 170 2 (2010): 453-467. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956186732&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2010.07.010
  40. Marques, F.; Sousa, J.C.; Coppola, G.; Geschwind, D.H.; Sousa, N.; Palha, J.A.; Correia-Neves, M.. "The choroid plexus response to a repeated peripheral inflammatory stimulus". BMC Neuroscience 10 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-71549130733&partnerID=MN8TOARS.
    10.1186/1471-2202-10-135
  41. Marques, F.; Sousa, J.C.; Coppola, G.; Falcao, A.M.; Rodrigues, A.J.; Geschwind, D.H.; Sousa, N.; Correia-Neves, M.; Palha, J.A.. "Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation". Journal of Cerebral Blood Flow and Metabolism 29 5 (2009): 921-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549167413&partnerID=MN8TOARS.
    10.1038/jcbfm.2009.15
  42. Bessa, J.M.; Ferreira, D.; Melo, I.; Marques, F.; Cerqueira, J.J.; Palha, J.A.; Almeida, O.F.X.; Sousa, N.. "The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling". Molecular Psychiatry 14 8 (2009): 764-773. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349216843&partnerID=MN8TOARS.
    10.1038/mp.2008.119
  43. Bessa, J.M.; Ferreira, D.; Melo, I.; Marques, F.; Cerqueira, J.J.; Palha, J.A.; Almeida, O.F.X.; Sousa, N.. "Hippocampal neurogenesis induced by antidepressant drugs: An epiphenomenon in their mood-improving actions". Molecular Psychiatry 14 8 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67651149865&partnerID=MN8TOARS.
    10.1038/mp.2009.75
  44. Marques, F.; Falcao, A.M.; Sousa, J.C.; Coppola, G.; Geschwind, D.; Sousa, N.; Correia-Neves, M.; Palha, J.A.. "Altered iron metabolism is part of the choroid plexus response to peripheral inflammation". Endocrinology 150 6 (2009): 2822-2828. http://www.scopus.com/inward/record.url?eid=2-s2.0-66649091212&partnerID=MN8TOARS.
    10.1210/en.2008-1610
  45. Pickering, C.; Hägglund, M.; Szmydynger-Chodobska, J.; Marques, F.; Palha, J.A.; Waller, L.; Chodobski, A.; et al. "The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury". BMC Neuroscience 9 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-54849431384&partnerID=MN8TOARS.
    10.1186/1471-2202-9-97
  46. Marques, F.; Rodrigues, A.-J.; Sousa, J.C.; Coppola, G.; Geschwind, D.H.; Sousa, N.; Correia-Neves, M.; Palha, J.A.. "Lipocalin 2 is a choroid plexus acute-phase protein". Journal of Cerebral Blood Flow and Metabolism 28 3 (2008): 450-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749163342&partnerID=MN8TOARS.
    10.1038/sj.jcbfm.9600557
  47. Marques, F.; Sousa, J.C.; Correia-Neves, M.; Oliveira, P.; Sousa, N.; Palha, J.A.. "The choroid plexus response to peripheral inflammatory stimulus". Neuroscience 144 2 (2007): 424-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845310881&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2006.09.029
  48. Marques, F.; Sousa, J.C.; Oliveira, P.; Oliveira, H.C.F.; Palha, J.A.. "The absence of transthyretin does not impair regulation of lipid and glucose metabolism". Hormone and Metabolic Research 39 7 (2007): 529-533. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547643226&partnerID=MN8TOARS.
    10.1055/s-2007-984395
  49. Sousa, J.C.; Marques, F.; Dias-Ferreira, E.; Cerqueira, J.J.; Sousa, N.; Palha, J.A.. "Transthyretin influences spatial reference memory". Neurobiology of Learning and Memory 88 3 (2007): 381-385. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548286470&partnerID=MN8TOARS.
    10.1016/j.nlm.2007.07.006
  50. Sousa, J.C.; Cardoso, I.; Marques, F.; Saraiva, M.J.; Palha, J.A.. "Transthyretin and Alzheimer's disease: Where in the brain?". Neurobiology of Aging 28 5 (2007): 713-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847345982&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2006.03.015
  51. Afonso, A.; Gomes, S.; Da Silva, J.; Marques, F.; Henrique, M.. "Side effects in sea bass (Dicentrarchus labrax L.) due to intraperitoneal vaccination against vibriosis and pasteurellosis". Fish and Shellfish Immunology 19 1 (2005): 1-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844256651&partnerID=MN8TOARS.
    10.1016/j.fsi.2004.09.001
  52. Sarmento, A.; Marques, F.; Ellis, A.E.; Afonso, A.. "Modulation of the activity of sea bass (Dicentrarchus labrax) head-kidney macrophages by macrophage activating factor(s) and lipopolysaccharide". Fish and Shellfish Immunology 16 2 (2004): 79-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242300086&partnerID=MN8TOARS.
    10.1016/S1050-4648(03)00031-7
  53. Do Vale, A.; Marques, F.; Silva, M.T.. "Apoptosis of sea bass (Dicentrarchus labrax L.) neutrophils and macrophages induced by experimental infection with Photobacterium damselae subsp. piscicida". Fish and Shellfish Immunology 15 2 (2003): 129-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038639727&partnerID=MN8TOARS.
    10.1016/S1050-4648(02)00144-4
Capítulo de livro
  1. Marques, Fernanda. "Beyond Brain Signaling". In Tissue-Specific Cell Signaling.. Suiça: Springer Nature, 2020.
    Publicado
  2. Marques, Fernanda. "As células do sistema nervoso – diversidade e função.". In Neurociências. Portugal: LIDEL, 2017.
    Publicado
  3. Marques, F.; Sousa, J.C.; Cerqueira, J.J.; Sousa, N.. "Detection of the glucocorticoid receptors in brain protein extracts by SDS-PAGE". In Tissue-Specific Cell Signaling.. 2014.
    10.1007/978-1-4939-1346-6_20
  4. Falcão, A.M.; Palha, J.A.; Ferreira, A.C.; Marques, F.; Sousa, N.; Sousa, J.C.. "Unbiased stereological method to assess proliferation throughout the subependymal zone". In Tissue-Specific Cell Signaling.. 2013.
    10.1007/978-1-62703-508-8_12
  5. Marques, Fernanda. "Brain Barriers and the Acute-Phase Response.". In In Acute Phase Proteins - Regulation and Functions of Acute Phase Proteins. IntechOpen, 2011.
    Publicado
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/10/21 Patch-seq analysis of the choroid plexus epithelial cell barrier in homeostasis and in Alzheimer’s disease Panel discussion at Society for Neuroscience (SfN)
Cure Alzheimer’s Fund, Targeting breakthrough research (Chicago, Estados Unidos)
2019/09/05 Role of astrocytic proteins in Multiple Sclerosis 18th National Meeting of the Spanish Society of Neuroscience
National Meeting of the Spanish Society of Neuroscience (Santiago de Compostela, Espanha)
2016/09/28 The Choroid plexus proteins from AD to neurogenesis 13Th International Congress of Neuroimmunology
International Congress of Neuroimmunology (Jerusalém, Israel)
2014/09/05 Barriers of the brain in health and disease: Contributions of choroid plexus proteins EURON WORKSHOP: New Targets in Neurodegenerative Diseases: Emphasis on advances in Alzheimer’s Disease research.
EURON (Braga, Portugal)
2014/03/06 Contributions of choroid plexus proteins in aging and in Alzheimer's disease 12th Psychoimmunology Expert Meeting.
Gunzberg University (Gunzberg, Alemanha)
2013/10/24 Blood Brain Barriers in aging and AD IBRO, International Symposium in Current aspects in pathophysiology of Alzheimer’s disease: What do we miss?
IBRO, International Symposium (Braga, Portugal)
2012/03/09 Multiple Sclerosis and iron homeostasis 11th Psychoimmunology Expert Meeting
University of Gunzberg (Gunzberg, Alemanha)
2010/07/07 The choroid plexus as a conveyor of immune signals into the brain 7th Forum of European Neuroscience (FENS).
Forum of European Neuroscience (FENS). (Amsterdam, Países Baixos)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2016/09/01 - 2020/08/31 Exploring the role of astrocytes in the pathophysiology of Multiple Sclerosis
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/06/01 - 2019/05/31 Dissecting pentraxin-3 role in the modulation of Multiple Sclerosis
Orientador
Universidade do Minho Escola de Medicina, Portugal
2018/06/01 - 2019/05/31 The potential role of innate immune memory in Multiple Sclerosis disease using experimental autoimmune encephalomyelitis mice model
Orientador
Universidade do Minho Escola de Medicina, Portugal
2017/06/01 - 2018/05/31 Striatal modulation by lipocalin-2
Orientador
Universidade do Minho Escola de Medicina, Portugal
2016/06/01 - 2017/05/31 Immune profile of an AD mice model
Orientador
Universidade do Minho Escola de Medicina, Portugal
2013/04/01 - 2017/03/29 Dissecting Lipocalin 2 as a novel modulator of brain processes
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/05/01 - 2016/10/31 The impact of choroid plexus derived factors in the subventricular zone neural progenitor cells niche
Coorientador
Universidade do Minho Escola de Medicina, Portugal
2014/06/01 - 2015/06/26 Studying the role of lipocalin-2 in the pathophysiology of multiple sclerosis – Looking beyond the brain
Orientador
Universidade do Minho Escola de Medicina, Portugal
2011/04/01 - 2015/03/31 Aging and Alzheimer's disease: Searching for novel molecular cues
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009/12/01 - 2013/11/30 Unraveling the biological role of neudesin, a novel neurotrophic factor
Coorientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011/06/01 - 2012/05/31 Searching for the role of lipocalin-2 in the central nervous system
Orientador
Universidade do Minho Escola de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019/09/04 - 2019/09/06 Symposium: “Not the usual suspects: new insights into damage and repair in the multiple sclerosis brain” in the 18th National Meeting of the Spanish Society of Neuroscience. Santiago de Compostela, Spain. September 4-6, 2019 (2019/09/04 - 2019/09/06)
Simpósio (Membro da Comissão Organizadora)
Universidade de Santiago de Compostela, Espanha
2019/08/28 - 2019/08/31 European Behavioural Pharmacology Society (EBPS) 2019 Biennial Meeting, Braga, Portugal. August 28-31, 2019 (2019/08/28 - 2019/08/31)
Congresso (Membro da Comissão Organizadora)
Universidade do Minho, Portugal
2017/05/25 - 2017/05/26 XV Meeting of the Portuguese Society for Neuroscience, Braga, Portugal. May 25-26, 2017. http://www.spnmeeting.pt/committees.html (2017/05/25 - 2017/05/26)
Encontro (Membro da Comissão Organizadora)
Universidade do Minho, Portugal
2014/08/31 - 2014/09/05 EURON WORKSHOP: New Targets in Neurodegenerative Diseases: Emphasis on advances in Alzheimer’s Disease research. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho. Braga, Portugal. August 31 - September 5, 2014. Supported by:• Internationale Stichting Alzheimer Onderzoek – ISAO (International Foundation Alzheimer Research) www.alzheimer.nl; • Ligue Européenne Contre la Maladie d’Alzheimer – LECMA www.maladiealzheimer.fr; • Alzheimer Forschung Initiative e.V. – AFI www.alzheimer-forschung.de; • FE (2014/08/31 - 2014/09/05)
Oficina (workshop) (Membro da Comissão Organizadora)
Universidade do Minho, Portugal
2012/04/13 - 2012/04/14 Meeting SINAL 2012 - 6th National Meeting on Cell Signaling. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho. Braga, Portugal. April 13-14, 2012 (2012/04/13 - 2012/04/14)
Encontro (Membro da Comissão Organizadora)
Universidade do Minho, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2021/02/08 Characterization of bitter taste receptors expression and function in the human blood-cerebrospinal fluid barrier
Arguente principal
Ana Catarina Abreu Duarte (Doutoramento)
Universidade da Beira Interior, Portugal
2018/11/20 Target S100B to reduce Experimental Autoimmune Encephalomyelitis pathogenesis
Arguente principal
Catarina da Silva Barros (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/12/13 Expression of Megalin in the central nervous system
Arguente principal
Joana dos Santos Peixoto Gomes (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
2017/10/24 Characterization of G¿o role on neuritogenesis: a focus on the G¿o-Amyloid Precursor Protein complex
Arguente principal
Roberto Alexandre dos Santos Dias (Doutoramento)
Universidade de Aveiro, Portugal
2017/07/26 Dissecting Lipocalin 2 as a novel modulator of brain processes
Vogal
Ana Catarina Oliveira Ferreira (Doutoramento)
2017/06/29 Evaluation of neuroprotective and neurotoxic functions of different microglia phenotypes in Alzheimer’s disease onset and progression, using in vitro and in vivo models
Arguente principal
Cláudia Alexandra Oliveira Lopes Caldeira (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/12/21 Searching for therapeutic strategies in a mouse model of Machado-Joseph disease: targeting proteostases
Vogal
Sara Carina Duarte da Silva (Doutoramento)
Universidade do Minho, Portugal
2015/07/17 Aging and Alzheimer's disease: Searching for novel molecular cues
Vogal
Sandro Gabriel Ferreira Dá Mesquita (Doutoramento)
Universidade do Minho, Portugal
2014/11/07 Neuro-glia-vascular alterations by common neonatal clinical conditions
Arguente principal
Filipa Solange Parreira Lourenço Cardoso (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/11/06 Role of Transthyretin in Aß efflux from the brain and uptake by liver- impact in Alzheimer’s Disease
Arguente principal
Cristiana Gaiteiro (Mestrado)
Universidade do Porto, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020/02/17 - Atual Guest Associate Editor in Cellular Neuroscience (Neurophysiology and Neuropathology) Frontiers
2013/11/01 - Atual Review Editor in Frontiers in Endocrinology (in Cancer Endocrinology) (1664-2392) Frontiers
2012/06/06 - 2012/09/25 Guest Associate Editor in Frontiers in Cellular Neuroscience (Pharmacology, Neuropharmacology) Frontiers

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2020/04/25 - Atual Evaluation commitee of the research proposal submitted to The Israel Science Foundation, on the Personal Research Grants.
Avaliador
The Israel Science Foundation, Israel The Israel Science Foundation
2019/11/15 - 2022/11/15 Commission for the evaluation of final reports of scientific projects IC&DT
Avaliador
Fundação para a Ciência e a Tecnologia, I.P., Portugal Fundação para a Ciência e a Tecnologia, I.P.

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019/05/21 - Atual Faculty member in the post-graduation course in “Training in Research Integrity and Bioethics” to teach “Introduction to biobank, European ethical and legal recommendations in biobanking and General data protection regulation (GDPR): rules and principles applied to biobanks”. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. May 21, 2019 (Pós-Graduação) Universidade do Minho, Portugal
2019/04/03 - Atual Faculty member in the post-graduation course in “Pathogenesis of neurodegenerative disease: finding a common ground” to teach “Basic mechanisms of disease (VIII): Inflammation” and “Multiple Sclerosis - disease mechanisms revisited”. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. April 2 and 4, 2019, 3rd Edition. (Pós-Graduação)
2017/03/28 - Atual Faculty member in the post-graduation course in “Pathogenesis of neurodegenerative disease: finding a common ground” to teach “Basic mechanisms of disease (VIII): Inflammation” and “Multiple Sclerosis - disease mechanisms revisited”. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. March 28 and 30, 2017. 2nd Edition. (Pós-Graduação)
2016/04/09 - Atual Faculty member in the training on “How to write a scientific article”. Pre-Exchange Training (PET) organized by the Núcleo de Estudantes de Medicina da Universidade do Minho (NEMUM) in partnership with the National Association of Medical Students (ANEM), School of Medicine, Braga, Portugal. April 9, 2016 (Licenciatura) Universidade do Minho, Portugal
2015/04/24 - Atual Faculty member in the post-graduation course in “Pathogenesis of neurodegenerative disease: finding a common ground” to teach “Multiple Sclerosis - disease mechanisms revisited”. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho. Braga, Portugal. April 24, 2015. 1st Edition. (Pós-Graduação) Universidade do Minho, Portugal
2011/09/02 - Atual Since 2011-present: Faculty member in the post-graduation course in “Fundamentals in Neuroscience” to teach “Brain Anatomy - hands-on”; “Barriers of the brain and brain metabolism”; “Inflammatory response in brain disorders” “Multiple Sclerosis - disease mechanisms”. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal (Pós-Graduação) Universidade do Minho, Portugal
2019/09/30 - 2019/10/18 Organization of the post-graduation course in “Fundamentals in Neuroscience”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. September 30 - October 18, 2019, 12th Edition (Pós-Graduação) Universidade do Minho, Portugal
2019/04/01 - 2019/04/05 Organization of the post-graduation course in “Pathogenesis of neurodegenerative disease: finding a common ground”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. Supported by FENS and IBRO. April 1-5, 2019, 3rd Edition. (Pós-Graduação) Universidade do Minho, Portugal
2018/09/10 - 2018/09/28 Organization of the post-graduation course in “Fundamentals in Neuroscience”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. September 10-28, 2018, 11th Edition. (Pós-Graduação) Universidade do Minho, Portugal
2017/09/11 - 2017/09/29 Organization of the post-graduation course in “Fundamentals in Neuroscience”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. September 11-29, 2017, 10th Edition (Pós-Graduação) Universidade do Minho, Portugal
2017/05/22 - 2017/05/26 Organization of the Module 2 about gene expression with a focus on qPCR in the post-graduation course in “Molecular and cellular analysis”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. May 22-26, 2017 (Pós-Graduação) Universidade do Minho, Portugal
2017/05/22 - 2017/05/24 Faculty member in the post-graduation course in “Molecular and cellular analysis” to teach “Gene expression analysis; RNA extraction methods; cDNA synthesis strategies; RNA extraction; RNA analysis; Primer design and data analysis”. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. May 22-24, 2017. (Pós-Graduação)
2017/03/27 - 2017/03/31 Organization of the post-graduation course in “Pathogenesis of neurodegenerative disease: finding a common ground”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. Supported by FENS and IBRO. March 27-31, 2017, 2nd Edition (Pós-Graduação) Universidade do Minho, Portugal
2016/09/12 - 2016/09/30 Organization of the post-graduation course in “Fundamentals in Neuroscience”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. September 12-30, 2016, 9th Edition (Pós-Graduação) Universidade do Minho, Portugal
2015/09/14 - 2015/09/25 Organization of the post-graduation course in “Fundamentals in Neuroscience”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Braga, Portugal. September 14-25, 2015, 8th Edition (Pós-Graduação) Universidade do Minho, Portugal
2015/04/20 - 2015/04/24 Organization of the post-graduation course in “Pathogenesis of neurodegenerative disease: finding a common ground”. For students of the 2nd and 3rd cycle. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho. Braga, Portugal. April 20-24, 2015, 1st Edition (Pós-Graduação) Universidade do Minho, Portugal
Distinções

Outra distinção

2019 Principal Investigator Researcher Salary Grant (CEECIND/01084/2017)
2013 Assistant Researcher Salary Grant (IF/00231/2013)
2008 Post-doctoral Fellowship (SFRH / BPD / 33379 / 2008)
2003 PhD Fellowship (SFRH/BD/11840/2003)