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PhD in Chemistry. 1997-2002, Universidad Autónoma de Madrid. PI: Francisco Sánchez-Madrid. Research: Chemotactic signaling in T cells. 24 peer-reviewed papers, of these first author in 9. Of these, one in Blood Journal, three in Journal of Immunology, one in European Journal of Immunology and one in Nature Reviews in Immunology. Post-doc. 2004-2011, University of Virginia. Supervisor: Prof. Alan Rick Horwitz. Research (1): Adhesion dynamics in migratory cells. Publications: Nature Cell Biology (1st and corresponding author). (2): Contraction as an integrator of migratory cell processes. Publications: Three papers in J. Cell Biol. (2007, 2008 y 2011); Nature Reviews in Molecular and Cellular Biology (>1400 citations); two papers in J. Cell Science. 1st and corresponding author in all of these. Two collaborations published in J. Cell Biol. (2006 and 2007). Mentoring: Supervised three PhD students, whose papers were published in J. Cell Biol., Nat. Cell Biol. and PLOS One (2). PI. 2011-present day. 2011-2017. Ramon y Cajal Assistant Professor at Universidad Autónoma de Madrid. Research: Role of mechanics in cell adhesion and migration. Funding: 4 domestic grants + 1 EU grant (Marie Curie 7th Framework Program, 2011). Publications: As last and corresponding author, J. Cell Biol., Dev. Cell, Curr. Biol. As co-author, Nature Immunology, Nat. Communications, etc. Mentoring: 3 PhD theses, 6 MSc theses and 9 grad theses. 2017-present day. Associate profesor of research CSIC/Universidad de Salamanca. Research: Role of mechanics in immune activation during the onset of cancer. Funding: 2 domestic grants and a CRUK-ACCELERATOR award as co-IP (5.000.000€). Publications: 3 papers under review. Mentoring: 2 PhD theses (in progress), 2 MSc theses.
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Identificação

Identificação pessoal

Nome completo
Miguel Vicente-Manzanares

Nomes de citação

  • Vicente-Manzanares, Miguel

Identificadores de autor

Ciência ID
D91C-099E-A2E7
ORCID iD
0000-0001-5943-3220

Telefones

Telefone
  • (34) 923294806 (Profissional)

Moradas

  • Centro de Investigacion del Cancer, Campus Unamuno, Avda. Coimbra s/n, 37007, Salamanca, Salamanca, Espanha (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Naturais - Ciências Biológicas - Biofísica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano (Idioma materno)
Formação
Grau Classificação
1997/01/01 - 2002/12/17
Concluído
 PhD in Molecular Biology (Doctor)
Universidad Autónoma de Madrid, Espanha
"Characterization of the roles of the enzyme PI3-kinase, GTPases of the Rho family and p160ROCK and mDia in lymphocyte polarization and migration " (TESE/DISSERTAÇÃO)
 Honors (top 1%)
1991/09/01 - 1996/06/30
Concluído
 Chemistry (Licence)
Especialização em Biochemistry
Universidad Complutense de Madrid, Espanha
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/03/16 - Atual Investigador principal (carreira) (Investigação) Consejo Superior de Investigaciones Científicas, Espanha
Instituto de Biología Molecular y Celular del Cáncer, Espanha
2011/03/01 - 2017/03/15 Investigador principal (carreira) (Investigação) Universidad Autónoma de Madrid Facultad de Medicina, Espanha
Universidad Autónoma de Madrid, Espanha
2004/08/01 - 2011/02/28 Investigador Contratado (Investigação) University of Virginia, Estados Unidos
University of Virginia, Estados Unidos
2003/01/01 - 2004/07/31 Pós-doutorado (Investigação) Universidad Autónoma de Madrid, Espanha
Universidad Autónoma de Madrid, Espanha
Projetos

Bolsa

Designação Financiadores
2020/03 - 2025/08 Early Cancer Research Initiative Network on MBL
C42023/A28998
 Cancer Research UK
2019/01 - 2022/12 Escalera de Excelencia Junta de Castilla Leon
JCyL-0001
 Junta de Castilla y León Consejería de Educación
2018/01/01 - 2021/12/31 Tissue mechanics and intracellular forces control tumor heterogeneity and immune evasion
SAF2017-87408-R
Investigador responsável
Instituto de Biología Molecular y Celular del Cáncer, Espanha
 MINECO
2018/01 - 2021/06 Control de la heterogeneidad y evasión inmune inmune tumoral por la mecánica tisular y la generación de fuerzas intracelulares
SAF2017-87408-R
 Ministerio de Economía y Competitividad
2018/11 - 2020/11 Modeling the role of mechanics in melanoma metastasis using Bioactive, ATP- and actin-dependent, contractile synthetic devices (BiAcode)
IDEAS18018VICE
 Fundación Científica de la Asociación Española Contra el Cáncer
2018/01 - 2019/12 Excellence Network in Mechanobiology (II)
BFU2017-90692-REDT
 Ministerio de Economía y Competitividad
2017/12 - 2018/11 Control de la evasión inmune en el melanoma mediante la regulación de la miosina no muscular de clase II
201720I09
 Fundación General CSIC
2015/01 - 2018/06 Determinantes mecánicos de la migración celular y la inmunidad
SAF2014-54705-R
 Ministerio de Economía y Competitividad
2015/01 - 2016/12 Excellence Network in Mechanobiology (I)
BFU2014-52586-REDT
 Ministerio de Economía y Competitividad
2014/12 - 2015/12 Mechanical tumor immune evasion
14_BBM_340
 Fundación BBVA
2011/09 - 2015/08 Myosin II integrates extracellular signals to control cell migration
293719
 Seventh Framework Programme
2012/07 - 2015/07 Myosin II controls stem cell migration and differentiation
CIVP16A1831
 Fundación Ramon Areces
2012/01 - 2014/12 Myosin II regulation in mechanotransduction
SAF2011-24953
 MINECO
2012/11 - 2013/11 Assistance to diagnosis using morphometric analysis of migrating cells
1/2011-53
 Wimasis SL
Produções

Publicações

Artigo em revista
  1. Vicente-Manzanares, Miguel; Aguilar-Cuenca, Rocio; Llorente-González, Clara; Chapman, Jessica; Talayero, Vanessa C; Garrido-Casado, Marina; Delgado-Arevalo, Cristina; et al. "Tyrosine phosphorylation of the myosin regulatory light chain controls non-muscle myosin II assembly and function in migrating cells". Current Biology (2020):
    Aceite para publicação
  2. Polesskaya A; Vicente-Manzanares M. "Meeting Report - Workshop 'Actin-based mechanosensation and force generation in health and disease'.". Journal of cell science (2020): http://europepmc.org/abstract/med/32184275.
    10.1242/jcs.244319
  3. Sonia Rodríguez-Fdez; Carmen Citterio; L. Francisco Lorenzo-Martín; Jesús Baltanás-Copado; Clara Llorente-González; Senena Corbalán-García; Miguel Vicente-Manzanares; Xosé R. Bustelo. "Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output". Cells 8 12 (2019): 1649-1649. https://doi.org/10.3390/cells8121649.
    10.3390/cells8121649
  4. Cibrian D; Castillo-González R; Fernández-Gallego N; de la Fuente H; Jorge I; Saiz ML; Punzón C; et al. "Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation.". The Journal of allergy and clinical immunology (2019): http://europepmc.org/abstract/med/31605740.
    10.1016/j.jaci.2019.09.025
  5. Domínguez-Luis MJ; Armas-González E; Herrera-García A; Arce-Franco M; Feria M; Vicente-Manzanares M; Martínez-Ruiz A; Sánchez-Madrid F; Díaz-González F. "L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling.". European journal of immunology (2018): http://europepmc.org/abstract/med/30443903.
    10.1002/eji.201847710
  6. Martín-Cófreces NB; Vicente-Manzanares M; Sánchez-Madrid F. "Adhesive Interactions Delineate the Topography of the Immune Synapse.". Frontiers in cell and developmental biology (2018): http://europepmc.org/abstract/med/30425987.
    10.3389/fcell.2018.00149
  7. Torralba D; Baixauli F; Villarroya-Beltri C; Fernández-Delgado I; Latorre-Pellicer A; Acín-Pérez R; Martín-Cófreces NB; et al. "Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.". Nature communications (2018): http://europepmc.org/abstract/med/29985392.
    10.1038/s41467-018-05077-9
  8. Vicente-Manzanares M; Sánchez-Madrid F. "Targeting the integrin interactome in human disease.". Current opinion in cell biology (2018): http://europepmc.org/abstract/med/30006051.
    10.1016/j.ceb.2018.05.010
  9. Toplak T; Palmieri B; Juanes-García A; Vicente-Manzanares M; Grant M; Wiseman PW. "Wavelet Imaging on Multiple Scales (WIMS) reveals focal adhesion distributions, dynamics and coupling between actomyosin bundle stability.". PloS one (2017): http://europepmc.org/abstract/med/29049414.
    10.1371/journal.pone.0186058
  10. Suñé-Auñón A; Jorge-Peñas A; Aguilar-Cuenca R; Vicente-Manzanares M; Van Oosterwyck H; Muñoz-Barrutia A. "Full L1-regularized Traction Force Microscopy over whole cells.". BMC bioinformatics (2017): http://europepmc.org/abstract/med/28797233.
    10.1186/s12859-017-1771-0
  11. Kreutzman A; Colom-Fernández B; Jiménez AM; Ilander M; Cuesta-Mateos C; Pérez-García Y; Arévalo CD; et al. "Dasatinib Reversibly Disrupts Endothelial Vascular Integrity by Increasing Non-Muscle Myosin II Contractility in a ROCK-Dependent Manner.". Clinical cancer research : an official journal of the American Association for Cancer Research (2017): http://europepmc.org/abstract/med/28821556.
    10.1158/1078-0432.ccr-16-0667
  12. Rocio Aguilar-Cuenca; Clara Llorente-Gonzalez; Carlos Vicente; Miguel Vicente-Manzanares. "Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1; referees: awaiting peer review]". (2017): https://f1000research.com/articles/6-160/v1.
    10.12688/f1000research.10356.1
  13. Cibrian D; Saiz ML; de la Fuente H; Sánchez-Díaz R; Moreno-Gonzalo O; Jorge I; Ferrarini A; et al. "Erratum: CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.". Nature immunology (2016): http://europepmc.org/abstract/med/27648548.
    10.1038/ni1016-1235c
  14. Cibrian D; Saiz ML; de la Fuente H; Sánchez-Díaz R; Moreno-Gonzalo O; Jorge I; Ferrarini A; et al. "CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.". Nature immunology (2016): http://europepmc.org/abstract/med/27376471.
    10.1038/ni.3504
  15. Andradas C; Blasco-Benito S; Castillo-Lluva S; Dillenburg-Pilla P; Diez-Alarcia R; Juanes-García A; García-Taboada E; et al. "Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.". (2016): http://europepmc.org/abstract/med/27340777.
    10.18632/oncotarget.10206
  16. Juanes-García A; Llorente-González C; Vicente-Manzanares M. "Molecular control of non-muscle myosin II assembly.". (2016): http://europepmc.org/abstract/med/26799185.
    10.18632/oncotarget.6936
  17. Ortega-Carrion A; Vicente-Manzanares M. "Concerning immune synapses: a spatiotemporal timeline.". (2016): http://europepmc.org/abstract/med/27092248.
    10.12688/f1000research.7796.1
  18. Moreno-Arotzena O; Borau C; Movilla N; Vicente-Manzanares M; García-Aznar JM. "Fibroblast Migration in 3D is Controlled by Haptotaxis in a Non-muscle Myosin II-Dependent Manner.". (2015): http://europepmc.org/abstract/med/26014363.
    10.1007/s10439-015-1343-2
  19. Mittelbrunn M; Vicente-Manzanares M; Sánchez-Madrid F. "Organizing polarized delivery of exosomes at synapses.". (2015): http://europepmc.org/abstract/med/25614958.
    10.1111/tra.12258
  20. Juanes-Garcia A; Chapman JR; Aguilar-Cuenca R; Delgado-Arevalo C; Hodges J; Whitmore LA; Shabanowitz J; et al. "A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front-back polarity.". (2015): http://europepmc.org/abstract/med/25869664.
    10.1083/jcb.201407059
  21. Jorge-Peñas A; Izquierdo-Alvarez A; Aguilar-Cuenca R; Vicente-Manzanares M; Garcia-Aznar JM; Van Oosterwyck H; de-Juan-Pardo EM; Ortiz-de-Solorzano C; Muñoz-Barrutia A. "Free Form Deformation-Based Image Registration Improves Accuracy of Traction Force Microscopy.". (2015): http://europepmc.org/abstract/med/26641883.
    10.1371/journal.pone.0144184
  22. Aguilar-Cuenca R; Vicente-Manzanares M. "Unleashing mesenchymal chemotaxis.". (2014): http://europepmc.org/abstract/med/25535912.
    10.1016/j.devcel.2014.12.005
  23. Aguilar-Cuenca R; Juanes-García A; Vicente-Manzanares M. "Myosin II in mechanotransduction: master and commander of cell migration, morphogenesis, and cancer.". (2014): http://europepmc.org/abstract/med/23934154.
    10.1007/s00018-013-1439-5
  24. Vicente-Manzanares M; Vicente Manzanares M. "Cell migration: cooperation between myosin II isoforms in durotaxis.". (2013): http://europepmc.org/abstract/med/23305668.
    10.1016/j.cub.2012.11.024
  25. Toplak T; Pandzic E; Chen L; Vicente-Manzanares M; Horwitz AR; Wiseman PW. "STICCS reveals matrix-dependent adhesion slipping and gripping in migrating cells.". (2012): http://europepmc.org/abstract/med/23083710.
    10.1016/j.bpj.2012.08.060
  26. Chen L; Vicente-Manzanares M; Potvin-Trottier L; Wiseman PW; Horwitz AR. "The integrin-ligand interaction regulates adhesion and migration through a molecular clutch.". (2012): http://europepmc.org/abstract/med/22792239.
    10.1371/journal.pone.0040202
  27. Vicente-Manzanares M; Horwitz AR. "Adhesion dynamics at a glance.". (2011): http://europepmc.org/abstract/med/22194302.
    10.1242/jcs.095653
  28. Díaz EM; Vicente-Manzanares M; Sacristan M; Vicente C; Legaz ME. "Fungal lectin of Peltigera canina induces chemotropism of compatible Nostoc cells by constriction-relaxation pulses of cyanobiont cytoskeleton.". (2011): http://europepmc.org/abstract/med/21897128.
    10.4161/psb.6.10.16687
  29. Vicente-Manzanares M; Newell-Litwa K; Bachir AI; Whitmore LA; Horwitz AR. "Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells.". (2011): http://europepmc.org/abstract/med/21482721.
    10.1083/jcb.201012159
  30. Hodges JL; Newell-Litwa K; Asmussen H; Vicente-Manzanares M; Horwitz AR. "Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology.". (2011): http://europepmc.org/abstract/med/21887379.
    10.1371/journal.pone.0024149
  31. Lamers ML; Almeida ME; Vicente-Manzanares M; Horwitz AF; Santos MF. "High glucose-mediated oxidative stress impairs cell migration.". (2011): http://europepmc.org/abstract/med/21826213.
    10.1371/journal.pone.0022865
  32. Vicente-Manzanares M; Horwitz AR. "Cell migration: an overview.". (2011): http://europepmc.org/abstract/med/21748665.
    10.1007/978-1-61779-207-6_1
  33. Vicente-Manzanares M; Horwitz AR. "Myosin light chain mono- and di-phosphorylation differentially regulate adhesion and polarity in migrating cells.". (2010): http://europepmc.org/abstract/med/20971064.
    10.1016/j.bbrc.2010.10.071
  34. Vicente-Manzanares M; Ma X; Adelstein RS; Horwitz AR. "Non-muscle myosin II takes centre stage in cell adhesion and migration.". (2009): http://europepmc.org/abstract/med/19851336.
    10.1038/nrm2786
  35. Vicente-Manzanares M; Choi CK; Horwitz AR. "Integrins in cell migration - the actin connection.". (2009): http://europepmc.org/abstract/PMC/PMC2777995.
  36. Vicente-Manzanares M; Hodges J; Horwitz AR. "Dendritic Spines: Similarities with Protrusions and Adhesions in Migrating Cells.". (2009): http://europepmc.org/abstract/med/20559447.
    10.2174/1874082000903020087
  37. Vicente-Manzanares M; Choi CK; Horwitz AR. "Integrins in cell migration--the actin connection.". (2009): http://europepmc.org/abstract/med/19118212.
    10.1242/jcs.018564
  38. Vicente-Manzanares M; Koach MA; Whitmore L; Lamers ML; Horwitz AF. "Segregation and activation of myosin IIB creates a rear in migrating cells.". (2008): http://europepmc.org/abstract/med/18955554.
    10.1083/jcb.200806030
  39. Choi CK; Vicente-Manzanares M; Zareno J; Whitmore LA; Mogilner A; Horwitz AR. "Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner.". (2008): http://europepmc.org/abstract/med/19160484.
    10.1038/ncb1763
  40. Owen KA; Pixley FJ; Thomas KS; Vicente-Manzanares M; Ray BJ; Horwitz AF; Parsons JT; et al. "Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase.". (2007): http://europepmc.org/abstract/med/18070912.
    10.1083/jcb.200708093
  41. Vicente-Manzanares M; Zareno J; Whitmore L; Choi CK; Horwitz AF. "Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells.". (2007): http://europepmc.org/abstract/PMC/PMC2064090.
  42. Vicente-Manzanares M; Zareno J; Whitmore L; Choi CK; Horwitz AF. "Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells.". (2007): http://europepmc.org/abstract/med/17312025.
    10.1083/jcb.200612043
  43. Cabrero JR; Serrador JM; Barreiro O; Mittelbrunn M; Naranjo-Suárez S; Martín-Cófreces N; Vicente-Manzanares M; et al. "Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.". (2006): http://europepmc.org/abstract/med/16738306.
    10.1091/mbc.E06-01-0008
  44. Nayal A; Webb DJ; Brown CM; Schaefer EM; Vicente-Manzanares M; Horwitz AR. "Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics.". (2006): http://europepmc.org/abstract/med/16717130.
    10.1083/jcb.200509075
  45. Martín-Cófreces NB; Sancho D; Fernández E; Vicente-Manzanares M; Gordón-Alonso M; Montoya MC; Michel F; et al. "Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.". (2006): http://europepmc.org/abstract/med/16547257.
    10.4049/jimmunol.176.7.4201
  46. Vicente-Manzanares M; Webb DJ; Horwitz AR. "Cell migration at a glance.". (2005): http://europepmc.org/abstract/med/16254237.
    10.1242/jcs.02662
  47. de la Fuente H; Mittelbrunn M; Sánchez-Martín L; Vicente-Manzanares M; Lamana A; Pardi R; Cabañas C; Sánchez-Madrid F. "Synaptic clusters of MHC class II molecules induced on DCs by adhesion molecule-mediated initial T-cell scanning.". (2005): http://europepmc.org/abstract/med/15872088.
    10.1091/mbc.E05-01-0005
  48. Vicente-Manzanares M; Cruz-Adalia A; Martín-Cófreces NB; Cabrero JR; Dosil M; Alvarado-Sánchez B; Bustelo XR; Sánchez-Madrid F. "Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav.". (2005): http://europepmc.org/abstract/med/15618472.
    10.1182/blood-2004-07-2925
  49. Barreiro O; Vicente-Manzanares M; Urzainqui A; Yáñez-Mó M; Sánchez-Madrid F. "Interactive protrusive structures during leukocyte adhesion and transendothelial migration.". (2004): http://europepmc.org/abstract/med/14977592.
    10.2741/1285
  50. Caloca MJ; Zugaza JL; Vicente-Manzanares M; Sánchez-Madrid F; Bustelo XR. "F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.". (2004): http://europepmc.org/abstract/med/14988412.
    10.1074/jbc.M313013200
  51. Sánchez-Martín L; Sánchez-Sánchez N; Gutiérrez-López MD; Rojo AI; Vicente-Manzanares M; Pérez-Alvarez MJ; Sánchez-Mateos P; et al. "Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1.". (2004): http://europepmc.org/abstract/med/14960575.
    10.1074/jbc.M400905200
  52. Vicente-Manzanares M; Sánchez-Madrid F. "Role of the cytoskeleton during leukocyte responses.". (2004): http://europepmc.org/abstract/med/15040584.
    10.1038/nri1268
  53. Gálvez BG; Matías-Román S; Yáñez-Mó M; Vicente-Manzanares M; Sánchez-Madrid F; Arroyo AG. "Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells.". (2004): http://europepmc.org/abstract/med/14657245.
    10.1091/mbc.E03-07-0516
  54. Vicente-Manzanares M; Vitón M; Sánchez-Madrid F. "Measurement of the levels of polymerized actin (F-actin) in chemokine-stimulated lymphocytes and GFP-coupled cDNA transfected lymphoid cells by flow cytometry.". (2004): http://europepmc.org/abstract/med/14573909.
  55. Vicente-Manzanares M; Rey M; Pérez-Martínez M; Yáñez-Mó M; Sancho D; Cabrero JR; Barreiro O; et al. "The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes.". (2003): http://europepmc.org/abstract/med/12847276.
    10.4049/jimmunol.171.2.1023
  56. Rey M; Vicente-Manzanares M; Viedma F; Yáñez-Mó M; Urzainqui A; Barreiro O; Vázquez J; Sánchez-Madrid F. "Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes.". (2002): http://europepmc.org/abstract/med/12421915.
    10.4049/jimmunol.169.10.5410
  57. Sancho D; Vicente-Manzanares M; Mittelbrunn M; Montoya MC; Gordón-Alonso M; Serrador JM; Sánchez-Madrid F. "Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions.". (2002): http://europepmc.org/abstract/med/12445267.
    10.1034/j.1600-065X.2002.18908.x
  58. Montoya MC; Sancho D; Vicente-Manzanares M; Sánchez-Madrid F. "Cell adhesion and polarity during immune interactions.". (2002): http://europepmc.org/abstract/med/12234363.
    10.1034/j.1600-065X.2002.18607.x
  59. Barreiro O; Yanez-Mo M; Serrador JM; Montoya MC; Vicente-Manzanares M; Tejedor R; Furthmayr H; Sanchez-Madrid F. "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.". (2002): http://europepmc.org/abstract/med/12082081.
    10.1083/jcb.200112126
  60. Serrador JM; Urzainqui A; Alonso-Lebrero JL; Cabrero JR; Montoya MC; Vicente-Manzanares M; Yáñez-Mó M; Sánchez-Madrid F. "A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at the trailing edge of migrating lymphocytes.". (2002): http://europepmc.org/abstract/med/12115638.
    10.1002/1521-4141(200206)32:6<1560::AID-IMMU1560>3.0.CO;2-U
  61. Serrador JM; Vicente-Manzanares M; Calvo J; Barreiro O; Montoya MC; Schwartz-Albiez R; Furthmayr H; Lozano F; Sánchez-Madrid F. "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting.". (2002): http://europepmc.org/abstract/med/11784723.
    10.1074/jbc.M110694200
  62. Vicente-Manzanares M; Cabrero JR; Rey M; Pérez-Martínez M; Ursa A; Itoh K; Sánchez-Madrid F. "A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis.". (2002): http://europepmc.org/abstract/med/11751986.
    10.4049/jimmunol.168.1.400
  63. Vicente-Manzanares M; Sancho D; Yáñez-Mó M; Sánchez-Madrid F. "The leukocyte cytoskeleton in cell migration and immune interactions.". (2002): http://europepmc.org/abstract/med/12049209.
    10.1016/S0074-7696(02)16007-4
  64. Rodríguez-Fernández JL; Sánchez-Martín L; Rey M; Vicente-Manzanares M; Narumiya S; Teixidó J; Sánchez-Madrid F; Cabañas C. "Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1.". (2001): http://europepmc.org/abstract/med/11489881.
    10.1074/jbc.M102896200
  65. Borroto A; Gil D; Delgado P; Vicente-Manzanares M; Alcover A; Sánchez-Madrid F; Alarcón B. "Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner.". (2000): http://europepmc.org/abstract/med/11093158.
    10.1002/1521-4141(2000012)30:12<3403::AID-IMMU3403>3.0.CO;2-H
  66. Vicente-Manzanares M; Sánchez-Madrid F. "Cell polarization: a comparative cell biology and immunological view.". (2000): http://europepmc.org/abstract/med/11097201.
    10.1155/2000/70801
  67. del Pozo MA; Vicente-Manzanares M; Tejedor R; Serrador JM; Sánchez-Madrid F. "Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes.". (1999): http://europepmc.org/abstract/med/10556816.
    10.1002/(SICI)1521-4141(199911)29:11<3609::AID-IMMU3609>3.0.CO;2-S
  68. Vicente-Manzanares M; Rey M; Jones DR; Sancho D; Mellado M; Rodriguez-Frade JM; del Pozo MA; et al. "Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.". (1999): http://europepmc.org/abstract/med/10491003.
  69. Vicente-Manzanares M; Montoya MC; Mellado M; Frade JM; del Pozo MA; Nieto M; de Landazuri MO; Martínez-A C; Sánchez-Madrid F. "The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes.". (1998): http://europepmc.org/abstract/med/9692889.
    10.1002/(SICI)1521-4141(199807)28:07<2197::AID-IMMU2197>3.0.CO;2-F
  70. del Pozo MA; Nieto M; Serrador JM; Sancho D; Vicente-Manzanares M; Martínez C; Sánchez-Madrid F. "The two poles of the lymphocyte: specialized cell compartments for migration and recruitment.". (1998): http://europepmc.org/abstract/med/9823463.

Outros

Outra produção
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    10.3410/f.725860630.793510955
  2. F1000Prime Recommendation. Pharmacological activation of myosin II paralogs to correct cell mechanics defects. 2015. Miguel Vicente-Manzanares. http://f1000.com/prime/725320595#eval793506646.
    10.3410/f.725320595.793506646
  3. F1000Prime Recommendation. Mechanical tension drives cell membrane fusion. 2015. Miguel Vicente-Manzanares. http://f1000.com/prime/725357909#eval793506466.
    10.3410/f.725357909.793506466
  4. F1000Prime Recommendation. F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse. 2015. Miguel Vicente-Manzanares. http://f1000.com/prime/725346833#eval793506450.
    10.3410/f.725346833.793506450
  5. F1000Prime Recommendation. Nuclear actin and myocardin-related transcription factors control disuse muscle atrophy through regulation of Srf activity. 2015. Miguel Vicente-Manzanares. http://f1000.com/prime/723891823#eval793503482.
    10.3410/f.723891823.793503482
  6. F1000Prime Recommendation. Induction of Focal Adhesions and Motility in Drosophila S2 cells. 2014. Miguel Vicente-Manzanares. http://f1000.com/prime/719128733#eval793501486.
    10.3410/f.719128733.793501486
  7. F1000Prime Recommendation. Characterization of three full-length human nonmuscle myosin II paralogs. 2014. Miguel Vicente-Manzanares. http://f1000.com/prime/718121791#eval793498125.
    10.3410/f.718121791.793498125
  8. F1000Prime Recommendation. Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. 2014. Miguel Vicente-Manzanares. http://f1000.com/prime/718358253#eval793494652.
    10.3410/f.718358253.793494652
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    10.3410/f.718280085.793491782
  10. F1000Prime Recommendation. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. 2014. Miguel Vicente-Manzanares. http://f1000.com/prime/718185728#eval793490380.
    10.3410/f.718185728.793490380
  11. F1000Prime Recommendation. ARP2/3-mediated junction-associated lamellipodia control VE-cadherin-based cell junction dynamics and maintain monolayer integrity. 2014. Miguel Vicente-Manzanares. http://f1000.com/prime/718175596#eval793490052.
    10.3410/f.718175596.793490052
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    10.3410/f.718043830.793484822
  13. F1000Prime Recommendation. Migration of T cells on surfaces containing complex nanotopography. 2013. Miguel Vicente-Manzanares. http://f1000.com/prime/718120695#eval793484775.
    10.3410/f.718120695.793484775
  14. F1000Prime Recommendation. Septin rings act as a template for myosin higher-order structures and inhibit redundant polarity establishment. 2013. Miguel Vicente-Manzanares. http://f1000.com/prime/718018521#eval793482324.
    10.3410/f.718018521.793482324
  15. F1000Prime Recommendation. Assembly of non-contractile dorsal stress fibers requires a-actinin-1 and Rac1 in migrating and spreading cells. 2013. Miguel Vicente-Manzanares. http://f1000.com/prime/718023656#eval793479423.
    10.3410/f.718023656.793479423
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    10.3410/f.718001898.793475286
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    10.3410/f.718001900.793475291
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    10.3410/f.717968593.793475290
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    10.3410/f.718001901.793475292
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    10.3410/f.5033957.4969055
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    10.3410/f.4942956.4875054
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    10.3410/f.1556030.1047138
  24. F1000Prime Recommendation. [CONFERENCE POSTER]: Regulation of adhesion dynamics by calpain-mediated proteolysis of FAK. 2010. Alan Rick Horwitz; Miguel Vicente-Manzanares. http://f1000.com/prime/1556031#eval1047139.
    10.3410/f.1556031.1047139
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    10.3410/f.1165092.627990
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Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/11/11 Novel modes of regulation of myosin-dependent force generation inside living cells Actin mechanosensation and force generation in health and disease
Universidad Internacional de Andalucia (Baeza, Espanha)
2019/03/31 Biophysics of myosin II activation and force generation in diverse cellular contexts CNIC Mechanobiology series
CNIC, Spain (Madrid, Espanha)
2016/06/20 Tyr phosphorylation of the RLC is a novel control mechanism of myosin II function European Cytoskeletal Forum
British Biochemical Society (Cambridge, Reino Unido)
2015/05/26 A Ser-based regulatory motif in the non-helical domain of myosin IIB determines its isoform-specific ability to generate stable polarity in 2-d mesenchymal cell migration Cellular synapsis for cell-cell signalling (EMBO Workshop)
EMBO (El Escorial, Espanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/02/01 - Atual Mechanical manipulation of tumor dynamics to halt metastasis
Orientador
 Cancer (Doutoramento)
Universidad de Salamanca, Espanha
2019/06/01 - Atual Mechanical determinants of dendritic cell morphology, migration and function
Orientador
 Immunology (Doutoramento)
Universidad de Salamanca, Espanha
2019/05/01 - Atual Mechanical determinants of shape and function in T cell activation and leukemic transformation
Orientador
 Immunology (Doutoramento)
Universidad de Salamanca, Espanha
2019/10/01 - 2020/06/30 Regulación de la miosina II no muscular en el contexto tumoral
Orientador
 Cancer (Mestrado)
Universidad de Salamanca, Espanha
2017/10/01 - 2018/06/30 Control of myosin II-B expression in the tumor context
Orientador
 Cancer (Mestrado)
Universidad de Salamanca, Espanha
2011/11/10 - 2017/07/10 Nuevos mecanismos de regulación de las funciones celulares de la proteína contráctil miosina II no muscular
Orientador de Rocio Aguilar Cuenca
 Molecular Biology (Doutoramento)
Universidad Autónoma de Madrid, Espanha
2016/09/01 - 2017/07/01 Funciones específicas de la contractilidad y el entrecruzamiento en el control de la tracción y la adhesión celular
Orientador
 Biochemistry (Mestrado)
Universidad Autónoma de Madrid, Espanha
2016/09/01 - 2017/06/29 Relación entre las fuerzas mecánicas y la activación de la NMII en la proliferación de los linfocitos T
Orientador
 Biochemistry (Licenciatura/Bacharelato)
Universidad Autónoma de Madrid, Espanha
2014/01/01 - 2017/06/23 Función del motor molecular miosina no muscular II-B en la regulación mecánica de la activación de los linfocitos T y la sinapsis inmune
Orientador de Alvaro Ortega Carrión
 Molecular biology (Doutoramento)
Universidad Autónoma de Madrid, Espanha
2011/09/10 - 2017/04/19 A regulatory motif in non-muscle myosin II-B regulates its assembly and determines its role in plasma membrane protrusion, adhesion dynamics and migratory polarization
Orientador de Alba Juanes Garcia
 Molecular Biology (Doutoramento)
Universidad Autónoma de Madrid, Espanha
2015/10/01 - 2016/09/14 La inhibición de la contractilidad promueve la diferenciación adipogénica de células madre mesenquimales
Orientador
 Biochemistry (Mestrado)
Universidad Autónoma de Madrid, Espanha
2015/09/10 - 2016/09/14 Cuantificación de las fuerzas mecánicas durante la diferenciación mioblástica
Coorientador
 Biomedical Engineering (Licenciatura/Bacharelato)
Universidad Carlos III de Madrid, Espanha
2015/09/01 - 2016/06/14 Regulación del ensamblaje de la miosina II-C por fosforilación del segmento C-terminal
Orientador
 biochemistry (Licenciatura/Bacharelato)
Universidad Autónoma de Madrid, Espanha
2015/09/01 - 2016/05/19 Expresión de reguladores de la contractilidad en los linfocitos T
Orientador
 Pharmacy (Licenciatura/Bacharelato)
Universidad Europea de Madrid SLU, Espanha
2014/09/01 - 2015/07/14 Efectos de la contractilidad y el entrecruzamiento de actina en la migracion celular
Orientador
 Biology (Licenciatura/Bacharelato)
Universidad Complutense de Madrid, Espanha
2014/09/01 - 2015/07/05 Sinergia y antagonismo entre multiples residuos fosforilables en la regulacion de la miosina no muscular de clase II durante la polarizacion y migracion linfoide
Orientador
 Biology (Mestrado)
Universidad Complutense de Madrid, Espanha
2013/09/01 - 2014/07/05 Alternative regulation of non-muscle myosin II function by phosphorylation of novel regulatory sites
Orientador
 Biology (Licenciatura/Bacharelato)
Universidad Complutense de Madrid, Espanha
2013/09/01 - 2014/07/05 Sinergia y antagonismo entre multiples residuos fosforilables en la regulacion de la miosina no muscular de clase II durante la polarizacion y migracion mesenquimal
Orientador
 biology (Licenciatura/Bacharelato)
Universidad Complutense de Madrid, Espanha
2013/09/01 - 2014/05/05 Expression of non-muscle myosin II isoforms and their upstream kinases during T cell activation
Orientador
 Biochemistry (Licenciatura/Bacharelato)
Universidad Autónoma de Madrid, Espanha
2012/09/01 - 2013/07/02 Mechanics of antigen presentation and dendritic cell migration
Orientador
 Molecular biology (Mestrado)
Universidad Autónoma de Madrid, Espanha
2012/09/01 - 2013/07/02 Role of NMII-B in the formation of the immune synapse
Orientador
 Molecular biology (Mestrado)
Universidad Autónoma de Madrid, Espanha
2011/10/01 - 2012/07/02 Novel phosphorylations of the myosin II-B isoform control cell adhesion, migration and polarity
Orientador de Rocio Aguilar Cuenca
 Molecular biology (Mestrado)
Universidad Autónoma de Madrid, Espanha
2011/09/01 - 2012/06/06 Identificacion funcional de nuevos sitios de fosforilacion que regulan la funcion celular de la miosina no muscular de clase II
Orientador de Irene Rios Guillen
 Biology (Licenciatura/Bacharelato)
Universidad Autónoma de Madrid, Espanha

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/11/01 - 2019/11/13 Actin mechanosensation in health and disease (2019/11/11 - 2019/11/13)
Oficina (workshop) (Coorganizador)
 Universidad Internacional de Andalucía, Espanha

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019/06/01 - Atual Cells (2073-4409) MDPI
2013/01/01 - Atual BMC Immunology (1471-2172) Springer (Biomed Central Ltd.)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2012/01/01 - Atual ANEP evaluation member
Avaliador
 Agencia Nacional de Evaluacion y Prospectiva, Espanha MINECO

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/01/25 - 2020/02/24 Immunotherapy: From basic biology to clinical application Cancer (Master) Universidad de Salamanca, Espanha
2019/01/25 - 2019/02/24 Immunotherapy: From basic biology to clinical application immunology (Master) Universidad de Salamanca, Espanha
2018/12/10 - 2019/01/20 Cell adhesion and migration in cancer cancer (Master) Universidad de Salamanca, Espanha
2017/12/10 - 2018/01/20 Cell adhesion and migration in cancer cancer (Master) Universidad de Salamanca, Espanha

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/01/01 - Atual Infrastructure committee of the Centro de Investigación del Cáncer, Salamanca, Spain
Diretor
 Instituto de Biología Molecular y Celular del Cáncer, Espanha