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Esteves AR graduated in Biology by the Faculdade de Ciências e Tecnologia da Universidade de Coimbra in 2006 and completed a PhD degree in Biology, specialization in Cell Biology by the Technology and Science Faculty of the University of Coimbra in 2011. During her PhD Esteves AR set out to depict the role of mitochondrial function and the synergistic pathways that can lead to neurodegeneration in Parkinsons disease (PD) working in close collaboration with Dr. Cristina Januário at Coimbra University Hospital. Moreover she completed her advanced training abroad in the lab of Dr Russell Swerdlow at the Research Institute of Kansas City, USA recognized expert in studying cell energy and mitochondrial metabolism and cell respiration. In 2011 Esteves AR integrated the CIBB (which integrates CNC/UC) as a postdoctoral researcher with a FCT fellowship. Currently she is a PhD Researcher at CIBB where she is studying the role of the microbiome-mitochondria crosstalk in the activation of neuronal innate immunity and its impact in the development of neurodegenerative diseases, namely PD. In fact, she was first author of a breakthrough paper published in Gut (IF: 31.793) where it was elucidated how a bacterial metabolite, that can cross the blood brain barrier, can drive PD neurodegeneration through mitochondrial dysfunction (Esteves et al., 2021, Gut - Q1 Gastroenterology). Overall, despite two interruptions in her scientific career due to 2 maternity leaves (2016 and 2019), Esteves AR published 45 papers in international peer reviewed journals (37 in Q1) with over 1,695 citations and with a h factor of 28 (WoS). From a total of 45, 31 are original papers and 18 were published as first author in top specialty peer-reviewed journals including Gut, The Neuroscientist, Antioxidants & Redox Signaling, J Neuroinflammation, Sci Reports and Redox Biology. Moreover, she was corresponding-author of 2 papers (Esteves et al., 2019, BBA-MBD; Arduino et al., 2011, CPD) and senior-author of 2 papers (Silva et al., 2022, Antioxidants; Guedes et al., 2023, Biomedicines). Proving her scientific leadership, she was co-supervisor of 3 master thesis and supervisor of 1 master student. Currently, she is co-supervisor of 2 master students and supervisor of 1 master student. Moreover, she was laboratory mentor of 4 PhD and 8 Master students, and supervised, during their laboratory internships, 5 PhD students, 14 Master students and 14 undergraduate students. Furthermore, she won 2 travel grants, 1 poster award (2017-International Symposium MitoPorto-Advances in mitochondrial research), 2 oral presentation awards (2013-XIII SPN Meeting; 2021- 55th Annual Scientific Meeting of the ESCI) and 3 FCT fellowships. Recently her work published on Gut was awarded with the Pfizer 2023 Award in Basic Research. She has participated in 14 research projects and was the principal investigator of an FCT project (2018) in collaboration with Dr. Merari from São Paulo University (Amount of funding: 224.839,22€). Currently, she is the principal investigator of an approved FCT project (Amount of funding: 49.981,25€). Moreover, she published 10 book chapters including publishers such as Springer and Elsevier and participated as first author in several scientific events with 42 (17 as first author and 1 as last auhtor) poster communications and with 48 (20 as first author) oral communications in which 10 were by invitation. She was also invited to edit 4 special journal issues in Current Pharmaceutical Design (2017), in Antioxidants (2021), in Frontiers in Aging (2022) and in Life (2023). She is also part of the editorial team of Frontiers in Cellular Neuroscience. Esteves AR expects to continue to advance our understanding of the gut-brain axis generating forefront knowledge in the field of neurodegenerative disorders, specifically PD, with important clinical implications.
Identificação

Identificação pessoal

Nome completo
Ana Esteves

Nomes de citação

  • Esteves, Ana Raquel

Identificadores de autor

Ciência ID
D914-E031-1545
ORCID iD
0000-0001-8403-2015

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2016/01/01 - 2019/08/31
Concluído
The role of NMNAT2 in axon degeneration: relevance to Parkinson’s disease. (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/04/01 - 2015/12/31
Concluído
Mitochondrial dysfunction disrupts autophagy through an axonal transport-dependent mechanism in MitoPark mice: the effects of microtubule stabilizers in the neurodegenerative process. (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011
Concluído
Biologia Celular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mitochondrial dysfunction: the road to alpha-synuclein oligomerization in Parkinson's disease" (TESE/DISSERTAÇÃO)
com distinção e louvor por unanimidade
2010/04/19 - 2010/04/30
Concluído
Course in Laboratory Animal Science training (previous cat. C) (Diploma de especialização)
Especialização em Experimentação Animal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006
Concluído
Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"MPP+ induced cell death characterization: mitochondria role in Parkinson’s disease" (TESE/DISSERTAÇÃO)
15
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2019/09/09 - Atual PhD Researcher (DOI 10.54499/DL57/2016/CP1448/CT0035) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/04/01 - 2019/08/31 Post-doctoral Fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/01 - 2011/01/01 PhD student Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/01/01 - 2009/07/01 Abroad Scientific training during PhD Kansas City University of Medicine and Biosciences, Estados Unidos
2005/09/15 - 2006/07/15 Internship Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projetos

Bolsa

Designação Financiadores
2023/01/09 - Atual GAinPD: Validation of bacterial-derived anti-inflammatory mediators in gut-first PD.
SC01: CP
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Cure Parkinson's
Em curso
2021 - 2024 STOPD - The Gut-Immune-Brain Axis in Parkinson disease
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2023/06/30 O Eixo microbioma-miRNAs na Doença de Parkinson: implicações da resposta inflamatória mediada pela mitocôndria
EXPL/MED-NEU/1515/2021
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - 2022/12/31 O Eixo Intestino-Sistema Imune-Cérebro na Doença de Parkinson
PTDC/MED-NEU/3644/2020
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/15 - 2021/06/15 The role of quality control mechanisms in the loss of proteostasis in age-dependent neurodegenerative disorders.
POCI-01-0145-FEDER-030712
Investigador responsável
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2017 - 2020 The toxinogenic gut microbiome in sporadic Parkinson’s Disease: a quest for new “antiPDbiotics”.
PTCRIS: 57310
Bolseiro de Pós-Doutoramento
Santa Casa da Misericórdia de Lisboa, Portugal
2016/01/01 - 2019/08/31 The role of NMNAT2 in axon degeneration: relevance to Parkinson’s disease.
SFRH/BPD/101878/2014
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018 - 2018 O papel dos metabolitos microbianos na doença de Parkinson
PTCRIS: 83206
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2017 AntiPDbiotics: The impairment of neuronal metabolism by gut microbiome effectors
FMUC-BST-2016-221
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/04/01 - 2015/12/31 Mitochondrial dysfunction disrupts autophagy through an axonal transport-dependent mechanism in MitoPark mice: the effects of microtubule stabilizers in the neurodegenerative process.
SFRH/BPD/75044/2010
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014 - 2014 Validate tau acetylation as an AD biomarker
GAI-FMUC
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2013 “Mitochondrial dependent impairment of intracellular trafficking in Parkinson’s disease”
PTDC/SAU-NEU/102710/2008
Investigador Pós-doutorado
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2011 Mitochondrial dysfunction induces alpha-synuclein oligomerization
SFRH/BD/32470/2006
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2009 O papel da disfunção mitocondrial na alteração do citoesqueleto: relevância para a Doença de Parkinson
GAI 07/08 FMUC
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
2008 - 2009 A associação entre a mitocôndria e o sistema ubiquitina/proteosoma no âmbito da doença de Parkinson.
GAI 15/08 FMUC
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
2005 - 2006 From mitochondrial dysfunction to protein aggregation in Parkinson’s disease.
GAI 03/04 FMUC
Internship
Universidade de Coimbra Faculdade de Medicina, Portugal
Concluído
Produções

Publicações

Artigo em revista
  1. Esteves, A. Raquel; Silva, Diana F.; Banha, Diogo; Candeias, Emanuel; Guedes, Beatriz; Cardoso, Sandra M.. "LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease". Redox Biology 63 (2023): 102714. http://dx.doi.org/10.1016/j.redox.2023.102714.
    10.1016/j.redox.2023.102714
  2. D. Magalhães, João; Candeias, Emanuel; Melo-Marques, Inês; Silva, Diana F.; Esteves, A. Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais. "Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson’s disease". Cellular and Molecular Life Sciences 80 6 (2023): http://dx.doi.org/10.1007/s00018-023-04819-3.
    10.1007/s00018-023-04819-3
  3. Guedes, Beatriz F. S.; Cardoso, Sandra Morais; Esteves, Ana Raquel. "The Impact of microRNAs on Mitochondrial Function and Immunity: Relevance to Parkinson's Disease". Biomedicines 11 5 (2023): 1349. http://dx.doi.org/10.3390/biomedicines11051349.
    10.3390/biomedicines11051349
  4. Magalhães, João D.; Esteves, Ana Raquel; Candeias, Emanuel; Silva, Diana F.; Empadinhas, Nuno; Cardoso, Sandra Morais. "The Role of Bacteria–Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson’s Disease". International Journal of Molecular Sciences 24 5 (2023): 4339. http://dx.doi.org/10.3390/ijms24054339.
    10.3390/ijms24054339
  5. Silva, Diana Filipa; Empadinhas, Nuno; Cardoso, Sandra Morais; Esteves, Ana Raquel. "Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation". Antioxidants 11 11 (2022): 2141. http://dx.doi.org/10.3390/antiox11112141.
    10.3390/antiox11112141
  6. Costa, Helena Nunes; Esteves, Ana Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais. "Parkinson's Disease: A Multisystem Disorder". Neuroscience Bulletin (2022): http://dx.doi.org/10.1007/s12264-022-00934-6.
    10.1007/s12264-022-00934-6
  7. Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut (2021): gutjnl-2021. http://dx.doi.org/10.1136/gutjnl-2021-326023.
    10.1136/gutjnl-2021-326023
  8. Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M.. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons". Journal of Neuroinflammation 17 1 (2020): http://dx.doi.org/10.1186/s12974-020-02004-y.
    10.1186/s12974-020-02004-y
  9. Esteves, A. R.; Cardoso, S. M.. "Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-70174-z.
    Aceite para publicação • 10.1038/s41598-020-70174-z
  10. Gonçalves, A Mafalda; Pereira-Santos, A Raquel; Esteves, A. Raquel; Cardoso, Sandra Morais; Empadinhas, Nuno. "THE MITORIBOSOME: A WORLD OF OPPORTUNITIES FOR MITOCHONDRIAL DYSFUNCTION TOWARD PARKINSON’S DISEASE". Antioxidants & Redox Signaling (2020): http://dx.doi.org/10.1089/ars.2019.7997.
    Publicado • 10.1089/ars.2019.7997
  11. Esteves, A. Raquel; Filipe, Filipa; Magalhães, João D.; Silva, Diana F.; Cardoso, Sandra M.. "The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease". Molecular Neurobiology 56 8 (2019): 5654-5670. http://dx.doi.org/10.1007/s12035-019-1483-8.
    10.1007/s12035-019-1483-8
  12. Esteves, Ana; Andreia Palma; Rui Gomes; Daniel Santos; Diana Silva; Sandra Morais Cardoso. "Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2019):
    Publicado
  13. Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia. "Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease". European Journal of Medicinal Chemistry 148 (2018): 255-267. http://dx.doi.org/10.1016/j.ejmech.2018.02.023.
    10.1016/j.ejmech.2018.02.023
  14. Hiremathad, Asha; Chand, Karam; Tolayan, Lori; Rajeshwari; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia. "Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy". Journal of Inorganic Biochemistry 179 (2018): 82-96. http://dx.doi.org/10.1016/j.jinorgbio.2017.11.015.
    10.1016/j.jinorgbio.2017.11.015
  15. Esteves, Ana R.; Arduíno, Daniela M.; Silva, Diana F.; Viana, Sofia D.; Pereira, Frederico C.; Cardoso, Sandra M.. "Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson’s Disease". Molecular Neurobiology 55 2 (2017): 1440-1462. http://dx.doi.org/10.1007/s12035-017-0420-y.
    10.1007/s12035-017-0420-y
  16. Esteves, A. Raquel; Cardoso, Sandra M.. "LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking". The Neuroscientist 23 1 (2016): 16-26. http://dx.doi.org/10.1177/1073858415616558.
    10.1177/1073858415616558
  17. Silva, D. F.; Esteves, A. R.; Oliveira, C. R.; Cardoso, S. M.. "Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer’s-Disease Related Pathology". Molecular Neurobiology 54 6 (2016): 4021-4040. http://dx.doi.org/10.1007/s12035-016-9951-x.
    10.1007/s12035-016-9951-x
  18. Ana Raquel Fernandes Esteves. "LRRK2 a pivotal player in mitochondrial dynamics and lysosomal clustering: highlights to sporadic Parkinson’s disease". Therapeutic Targets for Neurological Diseases (2015): http://dx.doi.org/10.14800/ttnd.629.
    Publicado • 10.14800/ttnd.629
  19. Esteves, A. R.; G-Fernandes, M.; Santos, D.; Januário, C.; Cardoso, S. M.. "The Upshot of LRRK2 Inhibition to Parkinson’s Disease Paradigm". Molecular Neurobiology 52 3 (2014): 1804-1820. http://dx.doi.org/10.1007/s12035-014-8980-6.
    10.1007/s12035-014-8980-6
  20. Esteves, A. Raquel; Swerdlow, Russell H.; Cardoso, Sandra M.. "LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis". Experimental Neurology 261 (2014): 206-216. http://dx.doi.org/10.1016/j.expneurol.2014.05.025.
    10.1016/j.expneurol.2014.05.025
  21. Santos, Daniel; Esteves, A. Raquel; Silva, Diana F.; Januário, Cristina; Cardoso, Sandra M.. "The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson’s Disease". Molecular Neurobiology 52 1 (2014): 573-586. http://dx.doi.org/10.1007/s12035-014-8893-4.
    10.1007/s12035-014-8893-4
  22. Esteves, A.R.; Gozes, I.; Cardoso, S.M.. "The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 1 (2014): 7-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS.
    10.1016/j.bbadis.2013.10.003
  23. Silva, D.F.; Santana, I.; Esteves, A.R.; Baldeiras, I.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M.. "Prodromal metabolic phenotype in MCI cybrids: Implications for Alzheimer's disease". Current Alzheimer Research 10 2 (2013): 180-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875000768&partnerID=MN8TOARS.
    10.2174/1567205011310020008
  24. Keri, R.S.; Quintanova, C.; Marques, S.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A.. "Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease". Bioorganic and Medicinal Chemistry 21 15 (2013): 4559-4569. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879689184&partnerID=MN8TOARS.
    10.1016/j.bmc.2013.05.028
  25. Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.. "Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease". Autophagy 9 1 (2013): 112-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195238&partnerID=MN8TOARS.
    10.4161/auto.22443
  26. Cardoso, S.M.; Esteves, A.R.; Arduno, D.M.. "Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease". Neurodegenerative Diseases 10 1-4 (2012): 38-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860223145&partnerID=MN8TOARS.
    10.1159/000332601
  27. Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic". Human Molecular Genetics 21 21 (2012): 4680-4702. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS.
    10.1093/hmg/dds309
  28. Martins-Branco, D.; Esteves, A.R.; Santos, D.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Januario, C.; Cardoso, S.M.. "Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?". Experimental Neurology 238 2 (2012): 89-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866521159&partnerID=MN8TOARS.
    10.1016/j.expneurol.2012.08.008
  29. Silva, D.F.F.; Esteves, A.R.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M.. "Amyloid-ß-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway". Journal of Alzheimer's Disease 26 3 (2011): 565-581. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053559887&partnerID=MN8TOARS.
    10.3233/JAD-2011-110423
  30. Arduino, D.M.; Esteves, A.R.; Silva, D.F.F.; Martins-Branco, D.; Santos, D.; Pimentel, D.F.G.; Cardoso, S.M.. "Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases". Current Pharmaceutical Design 17 31 (2011): 3446-3459. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055080733&partnerID=MN8TOARS.
    10.2174/138161211798072481
  31. Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.. "Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: When mitochondria get nasty". Parkinson's Disease (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953286639&partnerID=MN8TOARS.
    10.4061/2011/767230
  32. Silva, D.F.F.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondria: The common upstream driver of amyloid-ß and tau pathology in Alzheimers disease". Current Alzheimer Research 8 5 (2011): 563-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959926983&partnerID=MN8TOARS.
    10.2174/156720511796391872
  33. Cardoso, S.M.; Esteves, A.R.; Arduíno, D.M.; Silva, D.F.F.; Oliveira, C.R.. "Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD". Parkinson's Disease (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952169319&partnerID=MN8TOARS.
    10.4061/2011/693761
  34. Lu, Jianghua; Wang, Kaixuan; Rodova, Mariana; Esteves, Raquel; Berry, Diana; E, Lezi; Crafter, Adam; et al. "Polymorphic Variation in Cytochrome Oxidase Subunit Genes". Journal of Alzheimer's Disease 21 1 (2010): 141-154. http://dx.doi.org/10.3233/jad-2010-100123.
    10.3233/jad-2010-100123
  35. Esteves, A. Raquel. "Microtubule depolymerization potentiates alpha-synuclein oligomerization". Frontiers in Aging Neuroscience 1 (2010): http://dx.doi.org/10.3389/neuro.24.005.2009.
    10.3389/neuro.24.005.2009
  36. Lu, J.; Wang, K.; Rodova, M.; Esteves, R.; Berry, D.; Lezi, E.L.; Crafter, A.; et al. "Polymorphic variation in cytochrome oxidase subunit genes". Journal of Alzheimer's Disease 21 1 (2010): 141-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954963850&partnerID=MN8TOARS.
    10.3233/JAD-2010-100123
  37. Arduíno, D.M.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondrial metabolism modulation: A new therapeutic approach for Parkinson's disease". CNS and Neurological Disorders - Drug Targets 9 1 (2010): 105-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949908141&partnerID=MN8TOARS.
  38. Esteves, A.R.; Lu, J.; Rodova, M.; Onyango, I.; Lezi, E.; Dubinsky, R.; Lyons, K.E.; et al. "Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer". Journal of Neurochemistry 113 3 (2010): 674-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950661030&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2010.06631.x
  39. Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology". Neurobiology of Disease 37 3 (2010): 723-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949120541&partnerID=MN8TOARS.
    10.1016/j.nbd.2009.12.011
  40. Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R.. "Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease". Experimental Neurology 223 2 (2010): 294-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS.
    10.1016/j.expneurol.2009.06.008
  41. Branco, Diogo Martins. "Cross-talk between mitochondria and proteasome in Parkinson’s disease pathogenesis". Frontiers in Aging Neuroscience (2010): http://dx.doi.org/10.3389/fnagi.2010.00017.
    10.3389/fnagi.2010.00017
  42. Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Oxidative stress involvement in a-synuclein oligomerization in Parkinson's disease cybrids". Antioxidants and Redox Signaling 11 3 (2009): 439-448. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849086657&partnerID=MN8TOARS.
    10.1089/ars.2008.2247
  43. Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.; Oliveira, C.R.. "Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease". Neurochemistry International 55 5 (2009): 341-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649342203&partnerID=MN8TOARS.
    10.1016/j.neuint.2009.04.004
  44. Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R.. "ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells". BMB Reports 42 11 (2009): 719-724. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS.
  45. Esteves, A. Raquel F.; Domingues, A. Filipa; Ferreira, I. Luísa; Januário, Cristina; Swerdlow, Russell H.; Oliveira, Catarina R.; Cardoso, Sandra M.. "Mitochondrial function in Parkinson’s disease cybrids containing an nt2 neuron-like nuclear background". Mitochondrion 8 3 (2008): 219-228. http://dx.doi.org/10.1016/j.mito.2008.03.004.
    10.1016/j.mito.2008.03.004
  46. Domingues, A.F.; Esteves, A.R.F.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells". Neurotoxicity Research 13 1 (2008): 31-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649157955&partnerID=MN8TOARS.
    10.1007/BF03033365
  47. Domingues, A.F.; Arduíno, D.M.; Esteves, A.R.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease". Free Radical Biology and Medicine 45 6 (2008): 820-825. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949100005&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2008.06.007
Capítulo de livro
  1. Candeias, Emanuel; Nunes-Costa, Daniela; João Duarte Magalhães; Esteves, Ana Raquel; Ana Raquel Pereira-Santos; Inês Melo Marques; Beatriz Guedes; Empadinhas, Nuno; Sandra Morais Cardoso. "Candeias, E, Nunes-Costa D, Magalhães JD, Esteves AR, Pereira-Santos AR, Marques I, Guedes B, Empadinhas N, Cardoso SM. (2022) Neurotoxicity induced by ß-N-methylamino-L-alanine.". In Natural Molecules in Neuroprotection and Neurotoxicity. Elsevier Inc. Publisher., 2022.
    Publicado
  2. Esteves, A. Raquel; Silva, Diana F.; Santos, Daniel; Candeias, Emanuel; Filipe, Filipa; Cardoso, Sandra M.. "Mitochondria at the Base of Neuronal Innate Immunity in Alzheimer’s and Parkinson’s Diseases". In Mitochondrial Diseases. InTech, 2018.
    10.5772/intechopen.72612
  3. Emanuel Candeias; João Magalhães; Daniel Santos; Helena Costa; Diana Silva; Esteves, Ana Raquel; Sandra Morais Cardoso. "The Role of Autophagy in Parkinson’s disease Etiopathogenesis". In The Neuroscience of Parkinson's Disease. Elsevier Inc. Publisher, 2018.
  4. Esteves, Ana Raquel; Silva, Diana Filipa; Gonçalves-Fernandes, Maria; Gomes, Rui; Cardoso, Sandra Morais. "Regulation of Autophagy in Parkinson’s Disease". In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 197-212. Elsevier, 2016.
    10.1016/b978-0-12-802937-4.00011-9
  5. Esteves, Ana Raquel. "Mitochondrial Therapeutic Approaches in Parkinson’s Disease". In Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease, 183-205. Springer International Publishing, 2016.
  6. Arduíno, Daniela M.; Esteves, A. Raquel; Swerdlow, Russell H.; Cardoso, Sandra M.. "A Cybrid Cell Model for the Assessment of the Link Between Mitochondrial Deficits and Sporadic Parkinson’s Disease". In Methods in Molecular Biology, 415-424. Springer New York, 2015.
    10.1007/978-1-4939-2288-8_31
  7. Raquel, A.; R., Catarina; Morais, Sandra. "Autophagy, the “Master” Regulator of Cellular Quality Control: What Happens when Autophagy Fails?". In Autophagy - A Double-Edged Sword - Cell Survival or Death?. InTech, 2013.
    10.5772/55196
  8. Daniela Moniz Arduíno; Esteves, Ana Raquel; Diogo Martins-Branco; Daniel Santos; Diana Silva; Sandra Morais Cardoso. "Therapeutic Intervention at Cellular Clearance Mechanisms: significance to Parkinson’s disease.". In PD, Diagnosis Treatment and Prognosis, 1-34. Nova Science Publishers, 2011.
  9. Esteves, Ana Raquel; Daniela Moniz Arduíno; Diana Silva; Diogo Martins-Branco; Sandra Morais Cardoso. "Mitochondrial Metabolism in Aged-related Neurodegenerative disorders: Alzheimer's and Parkinson's diseases Revisited.". In Mitochondria: Structure, Functions and Dysfunctions, 187-244. Nova Science Publishers, 2010.
    Publicado
  10. Sandra Morais Cardoso; Esteves, Ana Raquel; Daniela Moniz Arduíno; Ana Filipa Domingues; Catarina Resende de Oliveira. "The crucial role of mitochondria in Parkinson’s disease.". In Recent Research Developments in Neuroscience, 43-84. Research Signpost, 2009.
Poster em conferência
  1. Candeias, Emanuel; Inês Melo Marques; Mario Munoz-Pinto; Esteves, Ana Raquel; João Duarte Magalhães; Diogo Reis Carneiro; Empadinhas, Nuno; Sandra Morais Cardoso. ""The gut-immune-brain axis in Parkinson disease".". Trabalho apresentado em AD/PD 2023 International Conference on Alzheimer¿s and Parkinson¿s Diseases and related neurological disorders, 2023.
  2. Beatriz Guedes; Duarte, Sónia; Sandra Morais Cardoso; Esteves, Ana Raquel. "Unmasking miRNA 486-5p role in Parkinson’s disease: inflammation in the spotlight.". Trabalho apresentado em AD/PD™ 2023 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders, 2023.
  3. Ana Raquel Pereira Santos; Candeias, Emanuel; João Duarte Magalhães; Esteves, Ana Raquel; Empadinhas, Nuno; Sandra Morais Cardoso. "Neuronal control of microglia through the mitochondria.". Trabalho apresentado em AD/PD 2023 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders, 2023.
  4. Ana Raquel Pereira Santos; Emanuel Candeias; Esteves, Ana Raquel; João Duarte Magalhães; Daniela Nunes-Costa; Igor Tiago; Madeira, Nuno; Empadinhas, Nuno; Sandra Morais Cardoso. "Unveiling the role of gut dysbiosis in Schizophrenia pathology.". Trabalho apresentado em FENS-Hertie Winter School: “Neuro-immune interactions in health and disease, 2023.
  5. Inês Melo Marques; Mario Munoz-Pinto; Emanuel Candeias; Esteves, Ana Raquel; Sandra Morais Cardoso. "Mitochondria dysfunction triggers ileum innate immunity in a PD mouse model.". Trabalho apresentado em VI meet.Lab, 2022.
  6. João Magalhães; Emanuel Candeias; Esteves, Ana Raquel; Susana Alarico; Ildete Ferreira; Ana Cristina Rego; Igor Tiago; Nuno Empadinhas; Sandra Morais Cardoso. "Intensive antibiotic administration generates motor deficits and neuronal mitochondria impairment.". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019.
  7. Emanuel Candeias; Esteves, Ana Raquel; Diana Silva; João Magalhães; Nuno Empadinhas; Sandra Morais Cardoso. "Pathogen-associated molecular patterns as culprits for mitochondria-related neurodegeneration: motor complications and Parkinson’s disease pathological hallmarks". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019.
    10.5220/0005279201680173
  8. Emanuel Candeias; Esteves, Ana Raquel; João Magalhães; Ildete Ferreira; Ana Cristina Rego; Nuno Empadinhas; Sandra Morais Cardoso. "Chronic antibiotic treatment induces neurodegenerative features through the mitochondria.". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Diseases Congress., 2019.
  9. Esteves, Ana Raquel; Emanuel Candeias; Diana Silva; João Magalhães; Nuno Empadinhas; Sandra Morais Cardoso. "Mitochondria as a probable target of a bacterial neurotoxin: Relevance to Parkinson’s disease etiology.". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Diseases Congress, 2019.
  10. Esteves, Ana Raquel; Sandra Morais Cardoso. "Differential protein expression in diverse brain areas: Are Alzheimer’s and Parkinson’s disease brain specific?". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Diseases Congress, 2019.
  11. Diana Silva; Emanuel Candeias; Esteves, Ana Raquel; João Magalhães; Ildete Ferreira; Ana Cristina Rego; Nuno Empadinhas; Sandra Morais Cardoso. "Cortical neurons exposed to bacteria metabolites develop alzheimer´s disease-related hallmarks.". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Diseases Congress., 2019.
  12. Esteves, Ana Raquel; Emanuel Candeias; Diana Silva; João Magalhães; Nuno Empadinhas; Sandra Morais Cardoso. "A bacterial neurotoxin negatively impacts mitochondrial metabolism: microbial twist for PD etiology.". Trabalho apresentado em International Symposium MitoPorto-Mitochondrial evolution, metabolism and disease, 2018.
  13. Diana Silva; Esteves, Ana Raquel; Emanuel Candeias; Nuno Empadinhas; Sandra Morais Cardoso. "The neurotoxin ß-methylamino-L-alanine (BMAA) acts on mitochondria to recapitulate PD related pathology.". Trabalho apresentado em 8th World Congress on Targeting Mitochondria, 2017.
  14. Esteves, Ana Raquel; Daniela Moniz Arduíno; Diana Silva; Sofia Viana; Frederico Pereira. "NAD+ dependent Sirtuin-2 controls autophagic turnover through microtubule deacetylation in Parkinson’s disease.". Trabalho apresentado em International Symposium MitoPorto - Advances in mitochondrial research, 2017.
  15. Diogo Martins-Branco; Esteves, Ana Raquel; Cristina Januário; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Parkinson disease: why is pathogenesis wandering from mitochondria to ubiquitin-proteasome system? – a case report.". Trabalho apresentado em 24th European Students' Conference, 2013.
  16. Esteves, Ana Raquel; Sandra Morais Cardoso. "Elucidation of LRRK2 role on mitochondrial mediated-microtubule dynamics: possible target for sporadic Parkinson’s disease.". Trabalho apresentado em 11th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD), 2013.
  17. Esteves, Ana Raquel; Sandra Morais Cardoso. "LRRK2 pathogenic function: a possible target for the treatment of sporadic Parkinson’s disease.". Trabalho apresentado em 2º PF2MUC symposium “Changing paradigms of science”, 2012.
  18. Daniel Santos; Daniela Moniz Arduíno; Esteves, Ana Raquel; Sandra Morais Cardoso. "Impaired mitochondrial dynamics in parkinson's disease.". Trabalho apresentado em 42th Annual Meeting of the Society for Neuroscience, 2012.
  19. Esteves, Ana Raquel; Daniela Moniz Arduíno; Sandra Morais Cardoso. "Cross-talk between mitochondria function, microtubules dynamics and mitophagy in Parkinson’s disease.". Trabalho apresentado em 26º Reunião Grupo de Estudos Envelhecimento Cerebral e Demência., 2012.
  20. Esteves, Ana Raquel; Daniela Moniz Arduíno; Catarina Resende de Oliveira; Illana Gozes; Sandra Morais Cardoso. "A microtubule-interacting peptide (NAP) prevents alpha-synuclein oligomerization in Parkinson’s disease.". Trabalho apresentado em 41th Annual Meeting of the Society for Neuroscience, 2011.
  21. Daniela Moniz Arduíno; Esteves, Ana Raquel; Catarina Resende de Oliveira; Sandra Morais Cardoso. "SIRT2 and HDAC6 deacetylases inhibition counterbalances the autophagic pathway deficits in Parkinson’s Disease by promoting tubulin acetylation.". Trabalho apresentado em 41th Annual Meeting of the Society for Neuroscience, 2011.
  22. Esteves, Ana Raquel; Daniela Moniz Arduíno; Illana Gozes; Sandra Morais Cardoso. "Mitochondrial dysfunction and alpha-synuclein oligomerization rescue by a microtubule interacting agent in Parkinson’s disease.". Trabalho apresentado em Targeting Mitochondria, 2011.
  23. Daniel Santos; Daniela Moniz Arduíno; Esteves, Ana Raquel; Sandra Morais Cardoso. "Altered mitochondrial fusion and fission underlie morphological changes in mitochondria in a Parkinson’s disease cell model.". Trabalho apresentado em 5th Annual Meeting on Cell Signaling, SINAL, 2011.
  24. Diana Raposo; Rosa Resende; Diana Silva; Daniela Moniz Arduíno; Esteves, Ana Raquel; Sandra Morais Cardoso. "Microtubule Modulation in an Alzheimer's Disease Cellular Model.". Trabalho apresentado em SINAL, 2011.
  25. Esteves, Ana Raquel; Daniela Moniz Arduíno; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Dysfunctional mitochondria uphold calpain activation in PD cybrids: contribution to Parkinson’s disease pathology.". Trabalho apresentado em 7th FENS Forum of European Neuroscience, 2010.
  26. Esteves, Ana Raquel; Daniela Moniz Arduíno; Russell Swerdlow; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson’s subject mitochondrial transfer.". Trabalho apresentado em ENINET Final Meeting, 2010.
  27. Jill Morris; Russell Swerdlow. "Investigation of insulin signaling in parkinson's disease cytoplasmic hybrid cells". Trabalho apresentado em Experimental Biology National Meeting, Anaheim, CA., 2010.
  28. Daniela Moniz Arduíno; Esteves, Ana Raquel; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Mitochondrial dysfunction mediated-SIRT2 activation impairs microtubule dependent autophagic pathway in Parkinson’s disease.". Trabalho apresentado em 40th Annual Meeting of the Society for Neuroscience, 2010.
  29. Daniela Moniz Arduíno; Esteves, Ana Raquel; Russell Swerdlow; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Mitochondrial dysfunction impairs autophagic lysosomal pathway: implications for parkinson’s disease.". Trabalho apresentado em 39th Annual Meeting of the Society for Neuroscience, 2009.
  30. Esteves, Ana Raquel; Daniela Moniz Arduíno; Russell Swerdlow; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Bioenergetic Failure Triggers Tubulin-Mediated alpha-Synuclein Oligomerization.". Trabalho apresentado em 38th Annual Meeting of the Society for Neuroscience, 2009.
  31. Daniela Moniz Arduíno; Esteves, Ana Raquel; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Mitochondria deficits compromise the protective autophagic-lysosomal pathway: evidences from several models of Parkinson’s disease.". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neurosciences, 2009.
  32. Daniela Moniz Arduíno; Esteves, Ana Raquel; Ana Filipa Domingues; Cláudia Pereira; Catarina Resende de Oliveira. "Mitochondria and endoplasmic reticulum interplay mediates cell death in Parkinson’s disease.". Trabalho apresentado em FENS Meeting, 2008.
  33. Esteves, Ana Raquel; Ana Filipa Domingues; Daniela Moniz Arduíno; Catarina Resende de Oliveira; Sandra Morais Cardoso. "High glucose prevents microtubules alterations and decrease lewy bodies like formation in a parkinson’s disease cybrids model.". Trabalho apresentado em FENS Meeting, 2008.
  34. Ana Filipa Domingues; Daniela Moniz Arduíno; Esteves, Ana Raquel; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Mitochondria and Ubiquitin-proteasome system interplay in Parkinson's disease.". Trabalho apresentado em FENS Meeting, 2008.
  35. Esteves, Ana Raquel; Ana Filipa Domingues; Daniela Moniz Arduíno; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Mitochondrial dysfunction towards protein aggregation in Parkinson’s disease: contribution of microtubule depolymerization.". Trabalho apresentado em 37th Annual Meeting of the Society for Neuroscience, 2007.
  36. Daniela Moniz Arduíno; Esteves, Ana Raquel; Ana Filipa Domingues; Maria Amélia Santos; Sandra Morais Cardoso; Catarina Resende de Oliveira. "Are novel hydroxypyridinone based iron-chelators potential candidates for neuroprotection in parkinson`s and alzheimer`s diseases?". Trabalho apresentado em Reunião da Sociedade Portuguesa de Neurociências, 2007.
  37. Esteves, Ana Raquel; Ana Filipa Domingues; Daniela Moniz Arduíno; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Lewy bodies like formation in parkinson’s disease cybrids.". Trabalho apresentado em Reunião da Sociedade Portuguesa de Neurociências, 2007.
  38. Ana Filipa Domingues; Daniela Moniz Arduíno; Esteves, Ana Raquel; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Cross-talk between mitochondria and ubiquitin-proteasome system in parkinson’s disease.". Trabalho apresentado em Reunião da Sociedade Portuguesa de Neurociências, 2007.
  39. Ana Filipa Domingues; Esteves, Ana Raquel; Catarina Resende de Oliveira; Sandra Morais Cardoso. "MPP+-induced toxicity in mitochondrial DNA depleted cells: Implications in Parkinson's disease.". Trabalho apresentado em XVth National Congress of Biochemistry, 2006.
  40. Esteves, Ana Raquel; Ana Filipa Domingues; Ildete Ferreira; Cristina Januário; Catarina Resende de Oliveira; Sandra Morais Cardoso. "The role of mitochondria in MPP+-induced toxicity in Parkinson disease cybrids.". Trabalho apresentado em XVth National Congress of Biochemistry, 2006.
  41. Ana Filipa Domingues; Esteves, Ana Raquel; Catarina Resende de Oliveira; Sandra Morais Cardoso. "O papel da mitocôndria na Doença de Parkinson.". Trabalho apresentado em V Congresso de Investigação em Medicina: Pedagogia e Ciência, 2006.
  42. Esteves, Ana Raquel; Ana Filipa Domingues; Catarina Resende de Oliveira; Sandra Morais Cardoso. "A vulnerabilidade dos cíbridos de Parkinson à toxicidade do MPP+.". Trabalho apresentado em V Congresso de Investigação em Medicina: Pedagogia e Ciência, 2006.
Resumo em conferência
  1. Sandra Morais Cardoso; Esteves, Ana Raquel; Diana Silva; Emanuel Candeias; Nuno Empadinhas. "The role of Mitochondria in neuronal innate immunity activation: Relevance for Parkinson´s disease.". Trabalho apresentado em Annual Meeting of the European Society of Clinical Investigation (Mitochondrial Workshop), Barcelona, 2018.
    Publicado
  2. Esteves, Ana Raquel; Daniela Moniz Arduíno; Catarina Resende de Oliveira; Illana Gozes; Sandra Morais Cardoso. "A microtubule-interacting peptide (NAP) prevents alpha-synuclein oligomerization in Parkinson’s disease.". Trabalho apresentado em Society for Neuroscience, Washington, 2011.
    Publicado
  3. Esteves, Ana Raquel; Daniela Moniz Arduíno; Russell Swerdlow; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Bioenergetic Failure Triggers Tubulin-Mediated alpha-Synuclein Oligomerization.". Trabalho apresentado em Chicago, USA, Society for Neuroscience, Chicago, 2009.
    Publicado
  4. Esteves, Ana Raquel; Ana Filipa Domingues; Daniela Moniz Arduíno; Catarina Resende de Oliveira; Sandra Morais Cardoso. "Mitochondrial dysfunction towards protein aggregation in Parkinson’s disease: contribution of microtubule depolymerization.". Trabalho apresentado em San Diego, USA, Society for Neuroscience., San Diego, 2007.
    Publicado
Tese / Dissertação
  1. Esteves, Ana Raquel. "Mitochondrial dysfunction induces alpha-synuclein oligomerization in Parkinson's disease". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2011.

Outros

Outra produção
  1. Invitation to edit Life Special issue: “Microbiome-miRNAs Axis Role in Human Health and Disease.”. 2023. Esteves, Ana Raquel.
  2. Invitation to edit Frontiers in Aging Research Topic: Autophagy and Metabolism: Drivers of Aging.. 2022.
  3. Invitation to edit special journal issue in Antioxidants Journal: Connecting the Dots between Oxidative Stress, Gut-Brain Axis and Neurodegenerative Diseases.. 2021. Esteves, Ana Raquel; Diana F Silva.
  4. Invitation to edit special journal issue in Current Pharmaceutical Design Journal entitled “Current Therapies and Treatments available to treat Neurodegenerative Diseases.”. 2017. Esteves, Ana Raquel. 10.2174/1381612823999170201153809.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/10/18 The role of microRNAs in Gut-first Parkinson´s disease. Neuroscience and Disease data-club
CNC (Coimbra, Portugal)
2023/06/07 Uncovering a candidate gut miRNA role in mitochondrial dysfunction and inflammation: impact on Parkinson's disease. (Last Author; Presenting Author) 57th Annual Scientific Meeting of the European Society for Clinical Investigation
(Prague, República Checa)
2023/05/19 The role of mitochondria in neuronal innate immunity activation: relevance for Parkinson's disease. (Invited speaker) Master’s in Biomedical Engineering -Neurobiology II classes
University of Coimbra (Coimbra, Portugal)
2023/03/22 Parkinsons disease: from the gut to the brain. DCV talk.
Department of Life Sciences, UC. (Coimbra, Portugal)
2021/11/18 "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria." (Invited speaker) II MAD retreat Science Out of the Box
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2021/10/29 Gut-brain role of microbiome in Parkinsons disease. (Invited speaker) Master in Biomedical Research: Mechanisms of cellular dysfunction in neurodevelopment, mental and neurodegenerative disorders Course.
(Coimbra, Portugal)
2021/06/11 Neuronal Listeria monocytogenes infection triggers mitochondrial dysfunction and alpha-synuclein expression: relevance to Parkinson’s disease. 55th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Online Event)
2021/06/10 The Parkinson Pandemic: a microbial toxin elicits Parkinsons disease-like neurodegeneration. (First Author/Speaker) 55th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Online Event)
2021/06/10 Bacterial endotoxin-mediated innate immunity activation through mitochondrial dysfunction in Parkinson´s disease. 55th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Online Event)
2021/06/10 Parkinson’s disease neurodegeneration is mediated by the gut microbiome. 55th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Online Event)
2019/05/22 The gut hypothesis for Alzheimer´s disease: bacterial metabolites cause bioenergetic failure and activation of innate immunity in cortical neurons. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Coim, Portugal)
2018/12/07 Bacterial neurotoxin targets mitochondria in Parkinson’s disease. (Invited Speaker) 1st Microbiome-Gut-Brain Axis Joint Meeting
Grupo Sinalização Mitocondrial na Neurodegenerescência (mitSiN) (Coimbra, Portugal)
2018/05/31 The role of Mitochondria in neuronal innate immunity activation: Relevance for Parkinson´s disease. Annual Meeting of the European Society of Clinical Investigation (Mitochondrial Workshop)
European Society of Clinical Investigation (Barcelona, Espanha)
2018/05/16 The hidden microbiome in Parkinson’s disease. BIT's 9th Annual World Congress of Neurotalk
BIT Congress Inc. (BIT Group Global Ltd.) ( Bangkok, Tailândia)
2017/12/21 Mitochondrial Metabolism Regulates Microtubule Acetylome: Impact for Parkinson’s Disease. (Invited Speaker) 2nd Meeting on Biomedical Research
CNC (Coimbra, Portugal)
2015/12/17 Parkinson's disease and defective autophagy. (Invited Speaker) Seminar for Medicine students of Medicine faculty at Coimbra University
Medicine Faculty, Coimbra University (Coimbra, Portugal)
2015/11/19 Neurobiologia da doença Bipolar: rumo a novas estratégias terapêuticas e biomarcadores. XI Congresso Nacional de Psiquiatria
Sociedade Portuguesa de Psiquiatria e Saúde Mental (Vila Moura, Portugal)
2015/04/29 LRRK2 regulation of macroautophagy: The good, the bad or the ugly? (Invited Speaker) Neurodegenerative disorders course from Programa Doutoral em Biologia Experimental e Biomedicina do Centro de Neurociências e Biologia Celular
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2014/09/23 Bridging Tau and Amyloid-ß pathologies in sporadic Alzheimer´s disease: Mitochondria under the spotlight. 2nd International Conference on Alzheimer’s Disease and Dementia
(Valencia, Espanha)
2014/06/15 Mitochondrial down-regulation of tubulin acetylation-dependent intracellular trafficking by SIRT2 impairs macroautophagy in Parkinson’s disease. (First Author/Speaker) Euromit, International Meeting on Mitochondrial Pathology
MetabERN (Tampere, Finlândia)
2014/06/15 Mitochondria: the unifying entity from amyloid-ß and Tau pathology to neurodegeneration in sporadic Alzheimer´s disease. Euromit, International Meeting on Mitochondrial Pathology
MetabERN (Tampere, Finlândia)
2013/05/30 LRRK2 as a player on mitochondrial and microtubule dynamics impairment in sporadic Parkinson’s disease. (First Author/Speaker) XIII SPN Meeting
SPN (Luso, Portugal)
2013/03/06 Bridging Alzheimer and Parkinson Diseases: Mitochondria the Common Upstream Driver 11th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD)
AP/PD (Florença, Itália)
2012/06/07 Ubiquitin Proteasome System in Parkinson’s Disease: a keeper or a witness? 19th ISCOMS, University Medical Center
ISCOMS (Groningen, Países Baixos)
2012/03/24 Ubiquitin Proteasome System in Parkinson’s Disease: a keeper or a witness? AIMS Meeting
AIMS (Lisboa, Portugal)
2012 Mitochondrial dysfunction blocks autophagy highways in Parkinson’s disease. PostDoc symposium of Faculty of Medicine
PostDoc (Coimbra, Portugal)
2011/10/20 SIRT2 Deacetylase Activity Controls the Autophagy-Lysosomal System by Modulating the Acetylation Dynamics of Tubulin Cytoskeleton. Targeting Mitochondria
ISANH (Berlim, Alemanha)
2011/09/17 Synergistic roles of the proteasome and mitochondria in alpha-synuclein oligomerization: implications in Parkinson’s Disease. VI YES Meeting
Eng. António de Almeida Foundation (Porto, Portugal)
2011/06 Acetylated Microtubules are required for an efficient autophagy progression: implications for Parkinson’s disease. 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos Envelhecimento Cerebral e Demência (Tomar, Portugal)
2011/06 Synergistic roles of the proteasome and mitochondria in alpha-synuclein oligomerization: implications in Parkinson’s disease. 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos Envelhecimento Cerebral e Demência (Tomar, Portugal)
2011/06 NAM and NAP rescues alpha-synuclein oligomers mediated toxicity in Parkinson’s disease cybrids via a mechanism involving Microtubules stabilization and Sirtuins. (First Author/Speaker) 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos Envelhecimento Cerebral e Demência (Tomar, Portugal)
2011/06 Abnormal mitochondrial morphology and structure by impaired mitochondrial fission/fusion balance in a Parkinson’s disease cell model. 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos Envelhecimento Cerebral e Demência (Tomar, Portugal)
2011/06 Mitochondrial function and oxidative stress markers in Mild Cognitive Impairment cybrids containing an NT2 neuron-like nuclear background. 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos Envelhecimento Cerebral e Demência (Tomar, Portugal)
2011/03/09 Mitochondrial Metabolic Control of Microtubule Dynamics Impairs the Autophagic Pathway in Parkinson’s Disease. 10th International Conference AD/PD
AD/PD (Barcelona, Espanha)
2010/12/15 Mitochondrial dysfunction: the road to alpha-synuclein oligomerization. (Invited Speaker) Lisbon Area Neuroscience Meeting at Instituto de Medicina Molecular
Instituto de Medicina Molecular (Lisboa, Portugal)
2010/11/19 Mitochondrial metabolism in age-related Parkinson’s disease. (Invited Speaker) Biology of Aging course from Programa Doutoral em Biologia Experimental e Biomedicina do Centro de Neurociências e Biologia Celular
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2010/06 Mitochondrial dysfunction-mediated autophagy impairment: relevance to Alzheimer´s disease. 24ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos Envelhecimento Cerebral e Demência (Tomar, Portugal)
2009/12 Mitochondria impairment in Parkinson’s disease induces the formation of alpha-synuclein oligomeric species. (Invited Speaker) VII Center for Neuroscience and Cell Biology Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2009/09 Mitochondrial dysfunction induce proteasomal impairment in ndufa knockdown cells. Yes Meeting
Yes Meeting (Porto, Portugal)
2009/06 Mitochondrial control of the autophagic-lysosomal pathway. 23ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos Envelhecimento Cerebral e Demência (Luso, Portugal)
2008/07/12 Mitochondrial dysfunction and post-translational modifications of alpha-synuclein. FENS Meeting
FENS (Genebra, Suiça)
2008/06 Calcium induces coupling of endoplasmic reticulum stress response with mitochondria to initiate cell death signaling in Parkinson’s disease. 22ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Luso, Portugal)
2008/06 Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids. (First Author/Speaker) 22ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Luso, Portugal)
2007/10 Mitochondrial dysfunction involvement in alpha-synuclein aggregation: contribution to Parkinson’s disease. Reunião das Doenças do Movimento
Sociedade Portuguesa das Doenças do Movimento (Figueira da Foz, Portugal)
2007/07 Association between microtubules depolymerization and mitochondrial dysfunction in Parkinson's disease. (First Author/Speaker) 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência.
Grupo de Estudos de Envelhecimento Cerebral e Demência. (Luso, Portugal)
2007/06 Cross-talk between mitochondrial dysfunction and proteasome failure: relevance of oxidative stress in parkinson’s disease. 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência.
Grupo de Estudos de Envelhecimento Cerebral e Demência. (Luso, Portugal)
2007/06 Correlation between endoplasmic reticulum stress and mitochondrial dysfunction in Parkinson`s disease. 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência.
Grupo de Estudos de Envelhecimento Cerebral e Demência. (Luso, Portugal)
2006/12/05 MPP+ induction of mitochondrial dependent Apoptosis requires functional mitochondria. XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2006/12/05 Mitochondrial Dysfunction Enhances MPP+ Induced Toxicity In Parkinson Disease Cybrids. (First Author/Speaker) XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
Sociedade Portuguesa de Farmacologia (Porto, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/01/01 - Atual The Role of Gut Immunity in Parkinson´s disease. (Chloe Lattes)
Orientador
Master in Cognitive and Integrated Neurosciences (Mestrado)
IUT Paul Sabatier, França
2023 - Atual Modulating Gut Inflammation with Sodium Butyrate: Validation of a New Anti-Inflammatory Strategy to Arrest Body-First PD. (Emanuel Abreu)
Coorientador
Integrated Medicine Master (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2023 - Atual Impact of Nutrition on Gut Microbiota: Implication to Parkinson's Disease. (Joana Sobral)
Coorientador
Mestrado Integrado em Medicina (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2023 - Atual The role of alpha-synuclein in Parkinsons disease. (Catarina Oliveira)
Coorientador
Master in Molecular and Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/09/01 - 2023/02/15 The role of candidate miRNAs to Parkinsons disease in mitochondrial-mediated innate-immunity activation in vitro. (Beatriz Guedes)
Orientador
Clinical Laboratory Genetics (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2021 Parkinson's disease: a link between systems. (Helena Costa)
Coorientador
Medicina (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2017 The role of the mitoribossome in mitochondrial function: implications for Parkinsons disease. (Ana Mafalda Gonçalves)
Coorientador
Medicina (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012 - 2015 Tau post-translational modifications in microtubule assembly in Parkinsons disease. (Andreia Palma)
Coorientador
Medicina (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/03 - 2014/06 How does autophagy modulate inflamassome activation in aging? Is the ER stress involved? (Inês Brás)
Coorientador
Bioquímica (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2024/02/12 - 2024/02/16 Pathogenic mechanisms in Neuropsychiatric and Neurodegenerative Disorders Advanced Course from PDBEB. (Laboratory Tutor) (2024/02/12 -2024/02/16) (2024/02/12 - 2024/02/16)
Oficina (workshop) (Outra)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/01/30 - 2023/02/02 From Synapses to Circuits and Brain Diseases Advanced Course (Module 3 - Pathogenic Mechanisms in Neuropsychiatric and Neurodegenerative Disorders) from PDBEB. (Laboratory Tutor) (2023/01/30 - 2023/02/02)
Outro (Outra)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/10/28 - 2022/11/18 Well-Being for Scientists (4 sessions event) (2022 - 2022)
Simpósio (Membro da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/12/20 - 2021/12/20 Encontro CIBB 2021 (2021/12/20 - 2021/12/20)
Encontro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/12/10 - 2012/12/14 Biology of Proteolysis in Pathology Advanced Course from the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) organized with Dra. Sandra Morais Cardoso and Dra. Paula Moreira at Center for Neuroscience and Cell Biology. (2012/12/10 - 2012/12/14)
Simpósio (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2022/09/29 - Atual European Investigator Nigth
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/09/22 - Atual European Investigator Nigth
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/03/07 - 2023/03/08 Flow Cytometry and Cell Sorting (From basic concepts to artificial intelligence applied to data analysis) Theoretical and Practical Course.
Outro
Flow Cytometry and Cell Sorting
Universidade de Coimbra Faculdade de Medicina, Portugal
2023/01/10 - 2023/01/10 Escola Básica do 1.º Ciclo do Areeiro, preparation and participation in activities and games correlated with the brain.
Outro
Semana da Ciência e Tecnologia
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/11/18 - 2020/11/19 Moderation of Metabolic Control Session on the Virtual I Scientific Retreat of Metabolism, Aging and Disease Area from CIBB.
Conferência
I Scientific Retreat of Metabolism, Aging and Disease Area
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/03/23 - 2018/03/23 Activities and games correlated with the brain-A Educação transforma.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/03/29 - 2017/03/29 Escola Básica do 1.º Ciclo da Murtosa, preparation and participation in activities and games correlated with the brain. Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/09/28 - 2016/09/28 Cell Culture Day, organized by VWR at BIOCANT.
Oficina (workshop)
Cell Culture Day
VWR International, Reino Unido
2015/03/06 - 2015/03/06 Activities and games correlated with the brain at Fórum Coimbra “Os Cérebros andam aí?”.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/12/02 - 2014/12/03 Cell Observer Spining-disk Training Session, organized by Microscopy Unit team from CNC and Dr. Soren Prag (Carl Zeiss specialist) from Carl Zeiss at CNC.
Oficina (workshop)
Cell Observer Spining-disk Training Session
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Carl Zeiss Jena GmbH, Alemanha
2014/09/24 - 2014/09/24 Live Cell Imaging Hands on Session organized by Microscopy Unit team from CNC and Dr. Monika Marx (Carl Zeiss specialist) from Carl Zeiss at CNC.
Oficina (workshop)
Live Cell Imaging Hands on Session
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Carl Zeiss Mikroskopie GmbH, Alemanha
2014/09/23 - 2014/09/23 Principles of Confocal Microscopy and LSM 710 System Hands on Session, organized by Microscopy Unit team from CNC and Dr. Monika Marx (Carl Zeiss specialist) from Carl Zeiss at CNC.
Oficina (workshop)
Principles of Confocal Microscopy and LSM 710 System Hands on Session
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Carl Zeiss Jena GmbH, Alemanha
2014/03/12 - 2014/03/12 Activities and games correlated with the brain at Parque Verde do Mondego, Coimbra “Os Neurocientistas saem à Rua”.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/02/20 - 2014/02/21 Seahorse Practical Session, organized by Microscopy Unit team from CNC and Dr. Maria Torvinen (Field Application Scientist) from Seahorse Bioscience at CNC.
Oficina (workshop)
Seahorse Practical Session
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014 Ciência Viva: a programme that offers young people the opportunity to get involved in research teams in science and technology institutions.
Outro
2013/03/18 - 2013/03/18 Escola Básica do 1.º Ciclo de Abadias, Figueira da Foz, preparation and participation in activities and games correlated with the brain.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/03/27 - 2012/03/27 3 Escolas Primárias em Milagres, Leiria, preparation and participation in activities and games correlated with the brain.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/03/12 - 2011/03/12 Colégio de Quiaios, presentation untitled “The Brain and neurodegenerative disorders” to 7º grade classes.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/03/25 - 2010/03/25 Colégio Bissaia Barreto, preparation and participation in activities and games correlated with the brain.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/11/24 - 2008/11/28 Biology of Proteolysis from Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) at CNC, organized by Dra. Sandra Cardoso, Dra. Claúdia Pereira and Dr. Paulo Pereira.
Outro
Biology of Proteolysis Course
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/03/05 - 2008/03/05 Escola Básica do 1º Ciclo de S. Martinho do Bispo, preparation and participation in activities and games correlated with the brain.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2008 Ciência Viva: a programme that offers young people the opportunity to get involved in research teams in science and technology institutions.
Outro
2007/03/15 - 2007/03/15 Colégio do Menino Jesus, preparation and participation in activities and games correlated with the brain.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/29 - 2007/02/02 Neurogenesis and Neural Stem Cells from Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) at CNC, organized by Dra. Cristina Rego and Dra. Inês Araújo.
Outro
Neurogenesis and Neural Stem Cells Course
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/22 - 2007/01/26 Neurodegenerative Disorders from Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) at CNC, organized by Dra. Claúdia Pereira, Dra. Paula Agostinho, Dra. Cristina Rego and Dr. Luís Almeida.
Outro
Neurodegenerative Disorders Course
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/15 - 2007/01/19 Cell Death and Survival Signaling from Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) at CNC, organized by Dra. Emília Duarte, Dra. Armanda Santos and Dr. Paulo Santos.
Outro
Cell death and Survival Signaling Course
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/10 - 2007/01/12 Estatística Aplicada Course from Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) at CNC., organized by Dr. Pedro Anastácio.
Outro
Estatística Aplicada
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006 - 2007 Ciência Viva: a programme that offers young people the opportunity to get involved in research teams in science and technology institutions.
Outro
2006/11/27 - 2006/12/01 Molecular Cell Biology Course from Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) at CNC, organized by Dr. Carlos Duarte and Dr. Edgar Gomes .
Outro
Molecular Cell Biology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006/03/04 - 2006/03/04 Jardim de Infância da Universidade de Coimbra, preparation and participation in activities and games correlated with the brain.
Outro
Brain Awareness Week Activities
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - 2006 Ciência Viva: a programme that offers young people the opportunity to get involved in research teams in science and technology institutions.
Outro

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2023 “Análise da expressão génica do HIF-1a e genes-alvo e de citocinas pró-inflamatórias na periodontite e diabetes mellitus tipo 2.”
Arguente
Laura Mariana Paulo Gouveia (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/29 "Alpha-synuclein acetylation and deacetylation-Impact on mitochondrial dynamics in Parkinsons disease"
Arguente principal
Beatriz Milhomens de Ferreira Mendes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/07/23 "Role of TFEB in autophagy in cell models of Huntington's disease"
Arguente principal
Luís Duarte (Mestrado)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - Atual Frontiers in Cellular Neuroscience
2020 - Atual Frontiers in Cell and Developmental Biology

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2023/10/30 - 2023/10/30 Call "Research South Tyrol/Alto Adige 2022" of the Autonomous Province of Bolzano-Alto Adige (Italy).
Avaliador
Provincia autonoma di Bolzano - Alto Adige, Itália Provincia autonoma di Bolzano - Alto Adige
2014/12/15 - 2014/12/16 Participation in the Poster Evaluation Panels at XII CNC Annual Meeting at Coimbra, 15th and 16th December 2014. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2011 - Atual Biologia do Envelhecimento Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2009 - 2010 Neurobiologia II Engenharia Biomédica (Mestrado) Universidade de Coimbra, Portugal

Expedição científica

Descrição da atividade Instituição / Organização
2021 - 2023 PostDoc Representative team. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023/10 - Atual Jury member of an employment contract at the Coimbra University with the following reference P048-23-12754.
2023/12/20 - 2023/12/20 Invited Chair of Research at CIBB Session I Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023 - 2023 Jury member of an employment contract at the Coimbra University with the following reference IT137-23-181.
2022/06/02 - 2022/06/02 Jury member of a employment contract at the Center for Neuroscience and Cell Biology with the following reference IT057-22-11571. Universidade de Coimbra, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023 - Atual Molecular Psychiatry
2023 - Atual npj Biofilms and Microbiomes
2023 - Atual Frontiers in Neuroscience
2022/04 - Atual Behavioural Brain Research
2021 - Atual Life
2020 - Atual Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2020 - Atual Scientific Reports
2020 - Atual Future Drug Discovery
2020 - Atual Molecular Neurobiology
2020 - Atual Expert Opinion on Therapeutic Targets
2018 - Atual Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2017 - Atual Journal of Alzheimer s Disease (1875-8908) IOS Press
2016 - Atual BioMed Research International (2314-6141) Hindawi Limited
2016 - Atual British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
2015 - Atual Neurochemical Research (1573-6903) Springer-Verlag
2013 - Atual Neurodegenerative Diseases (1660-2862) S. Karger AG
2012 - Atual PLoS ONE (1932-6203) Public Library of Science
2011 - Atual Current Pharmaceutical Design (1381-6128) Bentham Science
2011 - Atual Parkinson s Disease (2042-0080) Hindawi Limited

Tutoria

Tópico Nome do aluno
2021/01/01 - Atual Doctoral thesis laboratory co-supervision (Programa Doutoral em Biologia Experimental e Biomedicina (PDBEB). Project entitled: "Unveiling the role of gut dysbiosis in Schizophrenia pathology." Ana Raquel Santos
2021 - Atual Scientific and Laboratory Skills training of Biology BSc student from Faculty of Medicine, University of Coimbra. Inês Marques
2019/03/01 - Atual Doctoral thesis laboratory co-supervision (Programa Doutoral em Biologia Experimental e Biomedicina (PDBEB). Project entitled: "PDbiome triggers alpha-synuclein pathogenesis." João Duarte Magalhães
2011 - Atual Doctoral thesis laboratory co-supervision (PhD Biosciences, Faculty of Science and Technology, University of Coimbra). Project entitled: "Unraveling Sirtuin 3 & 4 role in Parkinson’s disease." Daniel Santos
2022/09 - 2023/09 Master thesis laboratory co-supervision (Master in Biochemistry, Science and Technology Faculty, Coimbra University). Project entitled: "Innate Immunity activation in macrophages by non-tuberculosis mycobacteria". Sara Freitas
2023/07/17 - 2023/07/21 Ciência Viva Summer Internships 2023 Rodrigo Castro
2023/07/17 - 2023/07/21 Ciência Viva Summer Internships 2023 Bárbara Revez
2022/10/01 - 2023/06/30 Scientific and Laboratory Skills training of Medicine BSc student from Faculty of Medicine, University of Coimbra João Almeida
2023/02/01 - 2023/02/28 Scientific and Laboratory Skills training of Master student in Molecular and Cellular Biology from Faculty of Sciences and Technology, University of Coimbra Catarina Oliveira
2023 - 2023 Scientific and Laboratory Skills training of Master student in Health Biology - Integrative Biology and Physiopathology-University of Clermont Auvergne, Clermont-Ferrand. Eva Raynaud
2020/09/01 - 2022/12/31 Scientific and Laboratory Skills training of Medicine BSc student from Faculty of Medicine, University of Coimbra. Emanuel Abreu
2021 - 2022 Scientific and Laboratory Skills training of Medicine BSc student from Faculty of Medicine, University of Coimbra. Catarina Empadinhas
2021/07/19 - 2021/07/23 Ciência Viva Summer Internships 2021 Margarida Marques
2019 - 2019 Scientific and Laboratory Skills training of Medicine BSc student from Faculty of Medicine, University of Coimbra. Joana Sobral.
2018 - 2018 Scientific and Laboratory Skills training of a Master student in Molecular and Cellular Biology from Faculty of Sciences and Technology, University of Coimbra. Marlene Domingues.
2018 - 2018 Scientific and Laboratory Skills training of a Master student in Biochemistry from Faculty of Sciences and Technology, University of Coimbra. Diogo Cardetas Banha.
2016 - 2018 Master thesis laboratory co-supervision (Biopharmaceutical Sciences, Pharmacy Faculty, Lisbon University). Project entitled: "The role of Beclin-1 deacetylation on autophagic flux in Alzheimers disease." Filipa Filipe
2016 - 2018 Scientific and Laboratory Skills training of Medicine BSc student from Faculty of Medicine, University of Coimbra. Franscisco Xavier Mano.
2016 - 2018 Scientific and Laboratory Skills training of Medicine BSc student from Faculty of Medicine, University of Coimbra. Helena Costa.
2015 - 2015 Scientific and Laboratory Skills training of Master student in Biomedical Research, IBILI - Institute of Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra. João Afonso A. Pereira da Silva.
2015 - 2015 Scientific and Laboratory Skills training of a Master student in Biomedical Research, IBILI - Institute of Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra. Sofia Morais.
2015 - 2015 Scientific and Laboratory Skills training of Medicine BSc student from Faculty of Medicine, University of Coimbra. Lara Mendes.
2014 - 2015 Master thesis laboratory co-supervision (Master in Cellular and Molecular Biology, Science and Technology Faculty, Coimbra University). Project entitled: "Post-translational modifications of tau protein in Alzheimer's disease." Rui Gomes
2014 - 2015 Scientific and Laboratory Skills training of a Master student in Biological Engineering from Instituto Superior Técnico, Lisbon. Maria Fernandes.
2011 - 2015 Doctoral thesis laboratory co-supervision (PhD Biosciences, Faculty of Science and Technology, University of Coimbra). Project entitled: "Mitochondrial signaling pathway in Alzheimer´s disease: disclosure of new therapeutic targets." Diana Silva
2014 - 2014 Scientific and Laboratory Skills training of a Master student in Biochemistry from Faculty of Sciences and Technology, University of Coimbra. Ana Dias.
2014 - 2014 Scientific and Laboratory Skills training of a Master student in Biochemistry from Faculty of Sciences and Technology, University of Coimbra. Nuno Mendes.
2014 - 2014 Scientific and Laboratory Skills training of a Master student in Molecular and Cellular Biology from Faculty of Sciences and Technology, University of Lisbon. Alberto Soares.
2014 - 2014 Scientific and Laboratory Skills training of a Master student in Molecular and Cellular Biology from Faculty of Sciences and Technology, University of Lisbon. Júlia Reis.
2014 - 2014 Scientific and Laboratory Skills training of Medicine BSc student from Faculty of Medicine, University of Coimbra. Hugo Cordeiro.
2013/10/01 - 2013/10/31 Scientific and Laboratory Skills training of a Master student in Experimental Physiopathology from Bioscience Institute, São Paulo University: Carolliny Moura da Silva.
2013 - 2013 Scientific and Laboratory Skills training of a Biology BSc student from Faculty of Sciences and Technology, University of Coimbra. Ana Rita Afonso.
2009 - 2012 Master thesis laboratory co-supervision (Master in Medicine, Medicine Faculty, Coimbra University). Project entitled: "Ubiquitin proteasomal system impairment potentiates alpha-synuclein oligomerization. " Diogo Martins-Branco
2010 - 2011 Master thesis laboratory co-supervision (Master in Cellular and Molecular Biology, Science and Technology Faculty, Coimbra University). Project entitled: "Regulation of mitochondrial fusion/fission in Parkinson¿s disease." Daniel Santos
2009 - 2010 Master thesis laboratory co-supervision (Master in Cellular and Molecular Biology, Science and Technology Faculty, Coimbra University). Project entitled: "Mitochondria: the common upstream driver of Aß and Tau pathology in Alzheimer’s disease." Diana Silva
2008 - 2010 Master thesis laboratory co-supervision (Master from University Degli Studi del Sannio, Italy). Project entitled: "Role of Mitochondrial Dysfunction on Tau Hyperphosphorylation." Alessandro De Stefano
2009 - 2009 Scientific and Laboratory Skills training of a Master student in Biomedical Research from Faculty of Medicine, University of Coimbra. Mónica Abreu.
2009 - 2009 Scientific and Laboratory Skills training of a Biology BSc student from Faculty of Sciences and Technology, University of Coimbra. Pedro Carreiras.
2008 - 2008 Scientific and Laboratory Skills training of a Biology BSc student from Faculty of Sciences and Technology, University of Coimbra. José Abrantes.
2007 - 2008 Scientific and Laboratory Skills training of a Medicine BSc student from Faculty of Medicine, University of Coimbra. Daniela Cardoso.
2007 - 2008 Scientific and Laboratory Skills training of a Medicine BSc student from Faculty of Medicine, University of Coimbra. Diogo Branco.
Distinções

Prémio

2023 Pfizer Award 2023 in Basic Research.
Pfizer Portugal, Portugal
2021 Best flash-talk oral communication Award, Session Basic Research (55th Annual Scientific Meeting of the ESCI)
European Society for Clinical Investigation, Países Baixos
2017 Best poster Award, Category Neuroscience and Cancer (MitoPorto Meeting)
MitoPorto Meeting 2017/Biochemical Journal, Portugal
2014 Janssen Neuroscience Award-winning research project (Esteves AR was a Co-author).
2014 Winning Oral Communication at 2th International Conference on Alzheimer disease & Dementia (Esteves AR was a co-author)
2013 Best fire-talk presentation of Fire Session III: Neurodegeneration and Neuroprotection III in the XIII SPN Meeting in Luso, Portugal.
Sociedade Portuguesa de Neurociências, Portugal
2012 Winning oral communication in the PostDoc symposium of Faculty of Medicine (Esteves AR was a co-author)
Universidade de Coimbra, Portugal
2011 Scientific Award for best oral communication in 2nd World Congress on Targeting Mitochondria in Berlin, Germany (Esteves AR was a co-author)
2011 Best paper in basic science of Faculty of Medicine
Universidade de Coimbra, Portugal
2010 Winning oral communication in 6th edition of Youth European Scientific Meeting (Esteves AR was a co-author)

Outra distinção

2010 Federation of European Neuroscience Societies (FENS) Travel Grant
2008 Federation of European Neuroscience Societies (FENS) Travel Grant
Health Canada Strategic Policy Branch, Canadá