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Isabel Gordo is a principal investigator at the Instituto Gulbenkian de Ciência, Portugal. She graduated in Physics and received a PhD in Evolutionary Genetics from the University of Edinburgh in 2002. Her Postdoctoral research was carried out at the Instituto Gulbenkian de Ciência where she then became leader of the Evolutionary Biology group in 2004. In 2010 she won an ERC Starting Grant, in 2015 a FCT Investigator Consolidator Grant and in 2023 an ERC Advanced Grant . She founded the Portuguese Society for Evolutionary Biology, serves as panel member and meanwhile vice-chair of the ERC grants evaluation since 2014, was elected EMBO member in 2017 and FEMS member in 2020. Her current research combines theoretical and empirical methods aiming at a better understanding of the major forces that shape genomic diversity of bacteria and their levels of resistance to antibiotics, in the context of the gut microbiome. She uses Escherichia coli as a model organism of bacteria and mice as a host model system to understand host-microbiome interactions.
Identificação

Identificação pessoal

Nome completo
Isabel Gordo

Nomes de citação

  • Gordo, Isabel

Identificadores de autor

Ciência ID
D311-B27E-BC34
ORCID iD
0000-0003-1622-5143

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia da Evolução das Espécies

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
1998 - 2002
Concluído
PhD program at the Instituto Gulbenkian de Ciencia (Doutoramento)
Especialização em Biology
University of Edinburgh, Reino Unido
"Accumulation of deleterious mutations by Muller's ratchet" (TESE/DISSERTAÇÃO)
N/A
2002
Concluído
Evolutionary Biology (Doutoramento)
Universidade Nova de Lisboa, Portugal
"The Accumulation of Deleterious Mutations by Muller´s Ratchet" (TESE/DISSERTAÇÃO)
1997
Concluído
Instituto Superior Tecnico (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"N/A" (TESE/DISSERTAÇÃO)
17 (em 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2015 - Atual Investigador Contratado (Investigação) Fundação Calouste Gulbenkian, Portugal
Instituto Gulbenkian de Ciência, Portugal
2004 - Atual Investigador principal (carreira) (Investigação) Instituto Gulbenkian de Ciência, Portugal
2002/10/01 - 2004/02/29 Pós-doutorado (Investigação) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2001/10/01 - 2001/12/31 Assistente de Investigação (carreira) (Investigação) University of Oxford, Reino Unido
Projetos

Bolsa

Designação Financiadores
2023/09/01 - 2028/09/30 Evolution in the Gut in Health and Disease
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
European Research Council
Em curso
2021 - 2025 Evolutionary diversification of E. coli in the mouse gut
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Deutsche Forschungsgemeinschaft
Em curso
2021 - 2024 Evolution of commensal bacteria in the mammalian intestine
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Em curso
2018 - 2021 CRC 1310 “Predictability of E. coli evolution in the mammalian gut”, Project A6
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Deutsche Forschungsgemeinschaft
Em curso
2018 - 2021 From diversity to efficiency
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 ResistEpist
Instituto Gulbenkian de Ciência, Portugal
Concluído
2019 - 2020 In vivo Long Term Evolution of a commensal in the Gut Microbiota
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Nature Research/Yakult
Concluído
2017 - 2020 Predicting the persistence of resistance across environments
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia

Joint Programming Initiative on Antimicrobial Resistance
Concluído
2014 - 2017 Adaptation of E. coli to a complex ecosystem
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Deutsche Forschungsgemeinschaft
Concluído
2013 - 2015 Fitness effects of synonymous mutations
PTDC /BIA-EVF/3247/2012
Outra
Instituto Gulbenkian de Ciência, Portugal
Concluído
2013 - 2015 Host microbe interaction at Instituto Gulbenkian Institution
Outra
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/12/01 - 2015 Microbial adaptation within ecosystems
Investigador responsável
European Research Council, Bélgica
European Commission
Concluído
2012/03/01 - 2014 Adaptation of commensal bacteria to the mammalian gut
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
European Commission
Concluído
2009 - 2014 Epistasis and evolution of antibiotic resistance
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/03/05 - 2010 Diversity and molecular evolution of pathogen populations
PTDC/BIA-BDE/65276/2006
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
European Commission
Concluído
2007 - 2009 Rates of mutations in the protozoa Tetrahymena thermophila
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2003/07/01 - 2007 Population genetics of adaptation in Escherichia coli
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
European Commission
Concluído
Produções

Publicações

Artigo em revista
  1. Frazão, Nelson; Gordo, Isabel. "Shared Evolutionary Path in Social Microbiomes". Molecular Biology and Evolution 40 7 (2023): http://dx.doi.org/10.1093/molbev/msad153.
    10.1093/molbev/msad153
  2. Frazão, Nelson; Gordo, Isabel. "Ecotype formation and prophage domestication during gut bacterial evolution". BioEssays 45 8 (2023): http://dx.doi.org/10.1002/bies.202300063.
    10.1002/bies.202300063
  3. Barreto, Hugo C.; Gordo, Isabel. "Intrahost evolution of the gut microbiota". Nature Reviews Microbiology 21 9 (2023): 590-603. http://dx.doi.org/10.1038/s41579-023-00890-6.
    10.1038/s41579-023-00890-6
  4. Ghenu, Ana-Hermina; Amado, André; Gordo, Isabel; Bank, Claudia. "Epistasis decreases with increasing antibiotic pressure but not temperature". Philosophical Transactions of the Royal Society B: Biological Sciences 378 1877 (2023): http://dx.doi.org/10.1098/rstb.2022.0058.
    10.1098/rstb.2022.0058
  5. Moura de Sousa, Jorge; Lourenço, Marta; Gordo, Isabel. "Horizontal gene transfer among host-associated microbes". Cell Host & Microbe 31 4 (2023): 513-527. http://dx.doi.org/10.1016/j.chom.2023.03.017.
    10.1016/j.chom.2023.03.017
  6. Frazão, N.; Konrad, A.; Amicone, M.; Seixas, E.; Güleresi, D.; Lässig, M.; Gordo, I.. "Two modes of evolution shape bacterial strain diversity in the mammalian gut for thousands of generations". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-33412-8.
    10.1038/s41467-022-33412-8
  7. Barreto, Hugo C.; Abreu, Beatriz; Gordo, Isabel. "Fluctuating selection on bacterial iron regulation in the mammalian gut". Current Biology 32 15 (2022): 3261-3275.e4. http://dx.doi.org/10.1016/j.cub.2022.06.017.
    10.1016/j.cub.2022.06.017
  8. Mukherjee, Debanjan; Chora, Ângelo Ferreira; Lone, Jean-Christophe; Ramiro, Ricardo S.; Blankenhaus, Birte; Serre, Karine; Ramirez, Mário; et al. "Host lung microbiota promotes malaria-associated acute respiratory distress syndrome". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-31301-8.
    10.1038/s41467-022-31301-8
  9. Stajic, Dragan; Bank, Claudia; Gordo, Isabel. "Adaptive Potential of Epigenetic Switching During Adaptation to Fluctuating Environments". Genome Biology and Evolution 14 5 (2022): http://dx.doi.org/10.1093/gbe/evac065.
    10.1093/gbe/evac065
  10. Isabel Gordo. "Population size matters for mutations". Nature Ecology & Evolution (2022): https://doi.org/10.1038/s41559-022-01670-w.
    10.1038/s41559-022-01670-w
  11. Dapa, Tanja; Ramiro, Ricardo Serotte; Pedro, Miguel Filipe; Gordo, Isabel; Xavier, Karina Bivar. "Diet leaves a genetic signature in a keystone member of the gut microbiota". Cell Host & Microbe 30 2 (2022): 183-199.e10. http://dx.doi.org/10.1016/j.chom.2022.01.002.
    Acesso aberto • Publicado • 10.1016/j.chom.2022.01.002
  12. Borges, Vítor; Isidro, Joana; Trovão, Nídia Sequeira; Duarte, Sílvia; Cortes-Martins, Helena; Martiniano, Hugo; Gordo, Isabel; et al. "SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal". Communications Medicine 2 1 (2022): http://dx.doi.org/10.1038/s43856-022-00072-0.
    10.1038/s43856-022-00072-0
  13. Amicone, Massimo; Borges, Vítor; Alves, Maria João; Isidro, Joana; Zé-Zé, Líbia; Duarte, Sílvia; Vieira, Luís; et al. "Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution". Evolution, Medicine, and Public Health 10 1 (2022): 142-155. http://dx.doi.org/10.1093/emph/eoac010.
    10.1093/emph/eoac010
  14. Durão, Paulo; Amicone, Massimo; Perfeito, Lília; Gordo, Isabel. "Competition dynamics in long-term propagations of Schizosaccharomyces pombe strain communities". Ecology and Evolution 11 21 (2021): 15085-15097. http://dx.doi.org/10.1002/ece3.8191.
    Acesso aberto • Publicado • 10.1002/ece3.8191
  15. Amicone, Massimo; Gordo, Isabel. "Molecular signatures of resource competition: Clonal interference favors ecological diversification and can lead to incipient speciation*". Evolution 75 11 (2021): 2641-2657. http://dx.doi.org/10.1111/evo.14315.
    Acesso aberto • Publicado • 10.1111/evo.14315
  16. Pinto, Catarina; Melo-Miranda, Rita; Gordo, Isabel; Sousa, Ana. "The Selective Advantage of the lac Operon for Escherichia coli Is Conditional on Diet and Microbiota Composition". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.709259.
    10.3389/fmicb.2021.709259
  17. Balbontín, Roberto; Frazão, Nelson; Gordo, Isabel. "DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria". Molecular Biology and Evolution 38 8 (2021): 3220-3234. http://dx.doi.org/10.1093/molbev/msab093.
    10.1093/molbev/msab093
  18. Barreto, Hugo C.; Cordeiro, Tiago N.; Henriques, Adriano O.; Gordo, Isabel. "Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-76017-1.
    10.1038/s41598-020-76017-1
  19. Barreto, Hugo C.; Cordeiro, Tiago N.; Henriques, Adriano O.; Gordo, Isabel. "Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-76017-1.
    10.1038/s41598-020-76017-1
  20. Luís Leónidas Cardoso; Paulo Durão; Massimo Amicone; Isabel Gordo. "Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut". Nature Ecology & Evolution (2020): https://doi.org/10.1038/s41559-020-1235-1.
    10.1038/s41559-020-1235-1
  21. Durão, Paulo; Ramiro, Ricardo S.; Pereira, Cátia; Juric, Jernej; Pereira, Delfina; Gordo, Isabel. "Radial Expansion Facilitates the Maintenance of Double Antibiotic Resistances". Antimicrobial Agents and Chemotherapy 64 9 (2020): http://dx.doi.org/10.1128/aac.00668-20.
    10.1128/aac.00668-20
  22. Ramiro, Ricardo S.; Durão, Paulo; Bank, Claudia; Gordo, Isabel. "Low mutational load and high mutation rate variation in gut commensal bacteria". PLOS Biology 18 3 (2020): e3000617. http://dx.doi.org/10.1371/journal.pbio.3000617.
    10.1371/journal.pbio.3000617
  23. Barreto, Hugo C.; Sousa, Ana; Gordo, Isabel. "The Landscape of Adaptive Evolution of a Gut Commensal Bacteria in Aging Mice". Current Biology 30 6 (2020): 1102-1109.e5. http://dx.doi.org/10.1016/j.cub.2020.01.037.
    10.1016/j.cub.2020.01.037
  24. Hugo C. Barreto; Nelson Frazão; Ana Sousa; Anke Konrad; Isabel Gordo. "Mutation accumulation and horizontal gene transfer in Escherichia coli colonizing the gut of old mice". Communicative & Integrative Biology (2020): https://doi.org/10.1080/19420889.2020.1783059.
    10.1080/19420889.2020.1783059
  25. Vítor Borges; Joana Isidro; Helena Cortes-Martins; Sílvia Duarte; Luís Vieira; Ricardo Leite; Isabel Gordo; et al. "Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal". Emerging Microbes & Infections (2020): 1-58. https://doi.org/10.1080/22221751.2020.1844552.
    10.1080/22221751.2020.1844552
  26. Frazão, Nelson; Sousa, Ana; Lässig, Michael; Gordo, Isabel. "Horizontal gene transfer overrides mutation in Escherichia coli colonizing the mammalian gut". Proceedings of the National Academy of Sciences 116 36 (2019): 17906-17915. http://dx.doi.org/10.1073/pnas.1906958116.
    10.1073/pnas.1906958116
  27. Gordo, Isabel. "Low Mutational Load Allows for High Mutation Rate Variation in Gut Commensal Bacteria". [] (2019): http://dx.doi.org/10.1101/568709.
    10.1101/568709
  28. Pedro, Miguel; Batista-Barroso, João; Pinto, Catarina; Dias, Joana; Gordo, Isabel; Xavier, Karina. "Understanding metabolic processes shaping adaptation of E. coli to the gut". Access Microbiology 1 1A (2019): http://dx.doi.org/10.1099/acmi.ac2019.po0215.
    10.1099/acmi.ac2019.po0215
  29. Isabel Gordo. "Evolutionary change in the human gut microbiome: From a static to a dynamic view". PLOS Biology (2019): https://doi.org/10.1371/journal.pbio.3000126.
    10.1371/journal.pbio.3000126
  30. Barroso-Batista, João; Pedro, Miguel Filipe; Sales-Dias, Joana; Pinto, Catarina Jesus Garcia; Pereira, Helena; Demengeot, Jocelyne; Gordo, Isabel; Xavier, Karina. "Specific Eco-Evolutionary Contexts in the Mouse Gut Reveal Escherichia coli Metabolic Versatility". SSRN Electronic Journal (2019): http://dx.doi.org/10.2139/ssrn.3433809.
    10.2139/ssrn.3433809
  31. Durão, Paulo; Balbontín, Roberto; Gordo, Isabel. "Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance". Trends in Microbiology 26 8 (2018): 677-691. http://dx.doi.org/10.1016/j.tim.2018.01.005.
    10.1016/j.tim.2018.01.005
  32. Özkaya, Özhan; Balbontín, Roberto; Gordo, Isabel; Xavier, Karina B.. "Cheating on Cheaters Stabilizes Cooperation in Pseudomonas aeruginosa". Current Biology 28 13 (2018): 2070-2080.e6. http://dx.doi.org/10.1016/j.cub.2018.04.093.
    10.1016/j.cub.2018.04.093
  33. Sousa, Ana; Ramiro, Ricardo S.; Barroso-Batista, João; Güleresi, Daniela; Lourenço, Marta; Gordo, Isabel. "Recurrent Reverse Evolution Maintains Polymorphism after Strong Bottlenecks in Commensal Gut Bacteria". Molecular Biology and Evolution 34 11 (2017): 2879-2892. http://dx.doi.org/10.1093/molbev/msx221.
    10.1093/molbev/msx221
  34. Sousa, Ana; Frazão, Nelson; Ramiro, Ricardo S; Gordo, Isabel. "Evolution of commensal bacteria in the intestinal tract of mice". Current Opinion in Microbiology 38 (2017): 114-121. http://dx.doi.org/10.1016/j.mib.2017.05.007.
    10.1016/j.mib.2017.05.007
  35. Proença, João T.; Barral, Duarte C.; Gordo, Isabel. "Commensal-to-pathogen transition: One-single transposon insertion results in two pathoadaptive traits in Escherichia coli -macrophage interaction". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/s41598-017-04081-1.
    10.1038/s41598-017-04081-1
  36. Moura de Sousa, Jorge; Balbontín, Roberto; Durão, Paulo; Gordo, Isabel. "Multidrug-resistant bacteria compensate for the epistasis between resistances". PLOS Biology 15 4 (2017): e2001741. http://dx.doi.org/10.1371/journal.pbio.2001741.
    10.1371/journal.pbio.2001741
  37. Lourenço, Marta; Ramiro, Ricardo S.; Güleresi, Daniela; Barroso-Batista, João; Xavier, Karina B.; Gordo, Isabel; Sousa, Ana. "A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut". PLOS Genetics 12 11 (2016): e1006420. http://dx.doi.org/10.1371/journal.pgen.1006420.
    10.1371/journal.pgen.1006420
  38. Ramiro, Ricardo S.; Costa, Henrique; Gordo, Isabel. "Macrophage adaptation leads to parallel evolution of genetically diverseEscherichia colismall-colony variants with increased fitness in vivo and antibiotic collateral sensitivity". Evolutionary Applications 9 8 (2016): 994-1004. http://dx.doi.org/10.1111/eva.12397.
    10.1111/eva.12397
  39. Azevedo, M.; Sousa, A.; De Sousa, J.M.; Thompson, J.A.; Proença, J.T.; Gordo, I.. "Trade-offs of Escherichia coli adaptation to an intracellular lifestyle in macrophages". PLoS ONE 11 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84954553298&partnerID=MN8TOARS.
    10.1371/journal.pone.0146123
  40. de Sousa, J.A.M.; Alpedrinha, J.; Campos, P.R.A.; Gordo, I.; Moura de Sousa, Jorge A.; Alpedrinha, João; Campos, Paulo R.A.; Gordo, Isabel. "Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model". PeerJ 2016 2 (2016): e2256. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992146396&partnerID=MN8TOARS.
    10.7717/PEERJ.2256
  41. Durão, P.; Güleresi, D.; Proença, J.; Gordo, I.. "Enhanced survival of rifampin- and streptomycin-resistant Escherichia coli inside macrophages". Antimicrobial Agents and Chemotherapy 60 7 (2016): 4324-4332. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976877620&partnerID=MN8TOARS.
    10.1128/AAC.00624-16
  42. Barroso-Batista, João; Demengeot, Jocelyne; Gordo, Isabel. "Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria". Nature Communications 6 1 (2015): http://dx.doi.org/10.1038/ncomms9945.
    10.1038/ncomms9945
  43. Moura de Sousa, Jorge; Sousa, Ana; Bourgard, Catarina; Gordo, Isabel. "Potential for adaptation overrides cost of resistance". Future Microbiology 10 9 (2015): 1415-1431. http://dx.doi.org/10.2217/fmb.15.61.
    10.2217/fmb.15.61
  44. Durão, Paulo; Trindade, Sandra; Sousa, Ana; Gordo, Isabel. "Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance". Molecular Biology and Evolution 32 10 (2015): 2675-2680. http://dx.doi.org/10.1093/molbev/msv143.
    10.1093/molbev/msv143
  45. Gordo, Isabel; Demengeot, Jocelyne; Xavier, Karina. "Escherichia coli adaptation to the gut environment: a constant fight for survival". Future Microbiology 9 11 (2014): 1235-1238. http://dx.doi.org/10.2217/fmb.14.86.
    10.2217/fmb.14.86
  46. Barroso-Batista, João; Sousa, Ana; Lourenço, Marta; Bergman, Marie-Louise; Sobral, Daniel; Demengeot, Jocelyne; Xavier, Karina B.; et al. "The First Steps of Adaptation of Escherichia coli to the Gut Are Dominated by Soft Sweeps". PLoS Genetics 10 3 (2014): e1004182. http://dx.doi.org/10.1371/journal.pgen.1004182.
    10.1371/journal.pgen.1004182
  47. Miskinyte, Migla; Gordo, Isabel. "Fitness Measurements of Evolved Esherichia coli". BIO-PROTOCOL 4 17 (2014): http://dx.doi.org/10.21769/bioprotoc.1228.
    10.21769/bioprotoc.1228
  48. Perfeito, L.; Sousa, A.; Bataillon, T.; Gordo, I.. "Rates of fitness decline and rebound suggest pervasive epistasis". Evolution 68 1 (2014): 150-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890874862&partnerID=MN8TOARS.
    10.1111/evo.12234
  49. Miskinyte, Migla; Sousa, Ana; Ramiro, Ricardo S.; de Sousa, Jorge A. Moura; Kotlinowski, Jerzy; Caramalho, Iris; Magalhães, Sara; Soares, Miguel P.; Gordo, Isabel. "The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages". PLoS Pathogens 9 12 (2013): e1003802. http://dx.doi.org/10.1371/journal.ppat.1003802.
    10.1371/journal.ppat.1003802
  50. Chelo, Ivo M.; Nédli, Judit; Gordo, Isabel; Teotónio, Henrique. "An experimental test on the probability of extinction of new genetic variants". Nature Communications 4 1 (2013): http://dx.doi.org/10.1038/ncomms3417.
    10.1038/ncomms3417
  51. Sousa A; Bourgard C; Wahl LM; Gordo I. "Rates of transposition in Escherichia coli.". (2013): http://europepmc.org/abstract/med/24307531.
    10.1098/rsbl.2013.0838
  52. Moura de Sousa, J.A.; Campos, P.R.; Gordo, I.. "An ABC method for estimating the rate and distribution of effects of beneficial mutations.". Genome biology and evolution 5 5 (2013): 794-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891475093&partnerID=MN8TOARS.
    10.1093/gbe/evt045
  53. Miskinyte, M.; Gordo, I.. "Increased survival of antibiotic-resistant Escherichia coli inside macrophages". Antimicrobial Agents and Chemotherapy 57 1 (2013): 189-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872035293&partnerID=MN8TOARS.
    10.1128/AAC.01632-12
  54. Teresa Avelar, A.; Perfeito, L.; Gordo, I.; Godinho Ferreira, M.; Teresa Avelar, Ana; Perfeito, Lília; Gordo, Isabel; Godinho Ferreira, Miguel. "Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy". Nature Communications 4 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883299936&partnerID=MN8TOARS.
    10.1038/ncomms3235
  55. Gordo, I.; Campos, P.R.A.. "Evolution of clonal populations approaching a fitness peak". Biology Letters 9 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872045759&partnerID=MN8TOARS.
    10.1098/rsbl.2012.0239
  56. Brito, P.H.; Rocha, E.P.C.; Xavier, K.B.; Gordo, I.. "Natural genome diversity of AI-2 quorum sensing in Escherichia coli: Conserved signal production but labile signal reception". Genome Biology and Evolution 5 1 (2013): 16-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876583216&partnerID=MN8TOARS.
    10.1093/gbe/evs122
  57. Brito, Patrícia H.; Rocha, Eduardo P.C.; Xavier, Karina B.; Gordo, Isabel. "Natural Genome Diversity of AI-2 Quorum Sensing in Escherichia coli: Conserved Signal Production but Labile Signal Reception". Genome Biology and Evolution 5 1 (2012): 16-30. http://dx.doi.org/10.1093/gbe/evs122.
    10.1093/gbe/evs122
  58. Trindade, S.; Sousa, A.; Gordo, I.. "Antibiotic resistance and stress in the light of Fisher's model". Evolution 66 12 (2012): 3815-3824. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870520677&partnerID=MN8TOARS.
    10.1111/j.1558-5646.2012.01722.x
  59. Sousa, A.; Magalhaes, S.; Gordo, I.. "Cost of antibiotic resistance and the geometry of adaptation". Molecular Biology and Evolution 29 5 (2012): 1417-1428. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862840054&partnerID=MN8TOARS.
    10.1093/molbev/msr302
  60. Gordo, I.; Perfeito, L.; Sousa, A.. "Fitness effects of mutations in bacteria". Journal of Molecular Microbiology and Biotechnology 21 1-2 (2012): 20-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856059615&partnerID=MN8TOARS.
    10.1159/000332747
  61. Silva, R.F.; MendonçaSí, S.C.M.; CarvalhoLuí, L.M.; Reis, A.M.; Gordo, I.; Trindade, S.; Dionisio, F.. "Pervasive sign epistasis between conjugative plasmids and Drug-Resistance chromosomal mutations". PLoS Genetics 7 7 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79960959549&partnerID=MN8TOARS.
    10.1371/journal.pgen.1002181
  62. Gordo, Isabel; Perfeito, Lília; Sousa, Ana. "Fitness effects of mutations in bacteria". Molecular Microbiology and Biotechnology 21 (2011): 20-35.
    Acesso aberto • Publicado
  63. Trindade, S.; Perfeito, L.; Gordo, I.. "Rate and effects of spontaneous mutations that affect fitness in mutator escherichia coli". Philosophical Transactions of the Royal Society B: Biological Sciences 365 1544 (2010): 1177-1186. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951595254&partnerID=MN8TOARS.
    10.1098/rstb.2009.0287
  64. Viana, D.S.; Gordo, I.; Sucena, É.; Moita, M.A.P.. "Cognitive and motivational requirements for the emergence of cooperation in a rat social game". PLoS ONE 5 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77649241170&partnerID=MN8TOARS.
    10.1371/journal.pone.0008483
  65. Brito, P.H.; Guilherme, E.; Soares, H.; Gordo, I.; Brito, Patricia H; Guilherme, Elsa; Soares, Helena; Gordo, Isabel. "Mutation accumulation in Tetrahymena". BMC Evolutionary Biology 10 1 (2010): 354. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149437221&partnerID=MN8TOARS.
    10.1186/1471-2148-10-354
  66. Marais, G.A.B.; Campos, P.R.A.; Gordo, I.. "Can intra-Y gene conversion oppose the degeneration of the human Y chromosome? A simulation study". Genome Biology and Evolution 2 1 (2010): 347-357. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958479780&partnerID=MN8TOARS.
    10.1093/gbe/evq026
  67. Trindade, S.; Sousa, A.; Xavier, K.B.; Dionisio, F.; Ferreira, M.G.; Gordo, I.. "Positive epistasis drives the acquisition of multidrug resistance". PLoS Genetics 5 7 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-68249108837&partnerID=MN8TOARS.
    10.1371/journal.pgen.1000578
  68. Gordo, I.; Gomes, M.G.M.; Reis, D.G.; Campos, P.R.A.. "Genetic diversity in the SIR model of pathogen evolution". PLoS ONE 4 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-62949215034&partnerID=MN8TOARS.
    10.1371/journal.pone.0004876
  69. Campos, P.R.A.; Neto, P.S.C.A.; De Oliveira, V.M.; Gordo, I.. "Environmental heterogeneity enhances clonal interference". Evolution 62 6 (2008): 1390-1399. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449112781&partnerID=MN8TOARS.
    10.1111/j.1558-5646.2008.00380.x
  70. Gordo, I.; Campos, P.R.A.. "Sex and deleterious mutations". Genetics 179 1 (2008): 621-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-51849148202&partnerID=MN8TOARS.
    10.1534/genetics.108.086637
  71. Perfeito, L.; Pereira, M.I.; Campos, P.R.A.; Gordo, I.. "The effect of spatial structure on adaptation in Escherichia coli". Biology Letters 4 1 (2008): 57-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949151137&partnerID=MN8TOARS.
    10.1098/rsbl.2007.0481
  72. Dionisio, F.; Gordo, I.. "Controlling excludability in the evolution of cooperation". Evolutionary Ecology Research 9 2 (2007): 365-373. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947631404&partnerID=MN8TOARS.
  73. Gökaydin, D.; Oliveira-Martins, J.B.; Gordo, I.; Gomes, M.G.M.. "The reinfection threshold regulates pathogen diversity: The case of influenza". Journal of the Royal Society Interface 4 12 (2007): 136-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846855361&partnerID=MN8TOARS.
    10.1098/rsif.2006.0159
  74. Combadão, J.; Campos, P.R.A.; Dionisio, F.; Gordo, I.. "Small-world networks decrease the speed of Muller's ratchet". Genetical Research 89 1 (2007): 7-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249711384&partnerID=MN8TOARS.
    10.1017/S0016672307008658
  75. Gordo, I.; Campos, P.R.A.. "Patterns of genetic variation in populations of infectious agents". BMC Evolutionary Biology 7 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34547925652&partnerID=MN8TOARS.
    10.1186/1471-2148-7-116
  76. Perfeito, L.; Fernandes, L.; Mota, C.; Gordo, I.. "Adaptive mutations in bacteria: High rate and small effects". Science 317 5839 (2007): 813-815. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547924819&partnerID=MN8TOARS.
    10.1126/science.1142284
  77. Campos, P.R.A.; Gordo, I.. "Pathogen genetic variation in small-world host contact structures". Journal of Statistical Mechanics: Theory and Experiment 12 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-37649029254&partnerID=MN8TOARS.
    10.1088/1742-5468/2006/12/L12003
  78. Perfeito, L.; Gordo, I.; Campos, P.R.A.. "The effect of spatial structure in adaptive evolution". European Physical Journal B 51 2 (2006): 301-306. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745051396&partnerID=MN8TOARS.
    10.1140/epjb/e2006-00222-x
  79. Faro, J.; Combadao, J.; Gordo, I.. "Did germinal centers evolve under differential effects of Diversity vs Affinity?". Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 4163 LNCS (2006): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750980693&partnerID=MN8TOARS.
  80. Gordo, I.; Campos, P.R.A.. "Adaptive evolution in a spatially structured asexual population". Genetica 127 1-3 (2006): 217-229. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746140082&partnerID=MN8TOARS.
    10.1007/s10709-005-4012-9
  81. Dionisio, F.; Gordo, I.. "The tragedy of the commons, the public goods dilemma, and the meaning of rivalry and excludability in evolutionary biology". Evolutionary Ecology Research 8 2 (2006): 321-332. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645865566&partnerID=MN8TOARS.
  82. Campos, P.R.; Combadão, J.; Dionisio, F.; Gordo, I.; Campos, P.R.A.. "Muller's ratchet in random graphs and scale-free networks.". Physical review. E, Statistical, nonlinear, and soft matter physics 74 4 Pt 1 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-35148876208&partnerID=MN8TOARS.
    10.1103/PhysRevE.74.042901
  83. Rosas, A.; Gordo, I.; Campos, P.R.A.. "Scaling, genetic drift, and clonal interference in the extinction pattern of asexual population". Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 72 1 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-27244449149&partnerID=MN8TOARS.
    10.1103/PhysRevE.72.012901
  84. Dionisio, F.; Conceição, I.C.; Marques, A.C.R.; Fernandes, L.; Gordo, I.. "The evolution of a conjugative plasmid and its ability to increase bacterial fitness". Biology Letters 1 2 (2005): 250-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-25444496227&partnerID=MN8TOARS.
    10.1098/rsbl.2004.0275
  85. Gordo, I.; Dionisio, F.. "Nonequilibrium model for estimating parameters of deleterious mutations". Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 71 3 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-37649029925&partnerID=MN8TOARS.
    10.1103/PhysRevE.71.031907
  86. Bachtrog, D.; Gordo, I.. "Adaptive evolution of asexual populations under Muller's ratchet". Evolution 58 7 (2004): 1403-1413. http://www.scopus.com/inward/record.url?eid=2-s2.0-3543125439&partnerID=MN8TOARS.
  87. Gordo, I.; Navarro, A.; Charlesworth, B.. "Muller's ratchet and the pattern of variation at a neutral locus". Genetics 161 2 (2002): 835-848. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035989428&partnerID=MN8TOARS.
  88. Gordo, I.; Charlesworth, B.. "Genetic linkage and molecular evolution". Current Biology 11 17 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0035806958&partnerID=MN8TOARS.
    10.1016/S0960-9822(01)00408-0
  89. Gordo, I.; Charlesworth, B.. "The speed of Muller's ratchet with background selection, and the degeneration of Y chromosomes". Genetical Research 78 2 (2001): 149-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034760459&partnerID=MN8TOARS.
  90. Gordo, I.; Charlesworth, B.. "The degeneration of asexual haploid populations and the speed of Muller's ratchet". Genetics 154 3 (2000): 1379-1387. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034090232&partnerID=MN8TOARS.
  91. Gordo, I.; Charlesworth, B.. "On the speed of Muller's ratchet". Genetics 156 4 (2000): 2137-2140. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034533786&partnerID=MN8TOARS.
Livro
  1. Charlesworth, B.; Betancourt, A.J.; Kaiser, V.B.; Gordo, I.. Genetic recombination and molecular evolution. 2009.
    10.1101/sqb.2009.74.015
Tese / Dissertação
  1. "Cardoso, Luís Leónidas . "The role of the gut microbiota in the subsistence of antibiotic resistance"". Doutoramento, 2020. http://hdl.handle.net/10362/98835.
  2. Sousa, Jorge André Pedro de Moura Borges de. "The role of clonal interference across genetic backgrounds and environments". Doutoramento, 2016. http://hdl.handle.net/10362/43664.
  3. Batista, João Miguel Barroso. "Adaptation of Escherichia coli to the mouse gut". Doutoramento, 2016. http://hdl.handle.net/10362/56396.
  4. "Lourenço, Marta Mansos. "Evolution of Escherichia coli in the mouse gut"". Mestrado, 2014. https://repositorio.ul.pt/bitstream/10451/15760/1/ulfc107487_tm_marta_lourenco.pdf.
  5. Miskinyte, Migla. "Role of biotic interactions in generating and maintaining biodiversity". Doutoramento, 2013. http://hdl.handle.net/10362/10881.
  6. "Alvelar, Ana Teresa. "Chromosomal Structure: a selectable trait for evolution"". Doutoramento, 2012. https://run.unl.pt/handle/10362/8576?locale=en.
  7. Trindade, Sandra Isabel Gonçalves, 1982-. "The impact of genetic interactions in antibiotic resistance". Doutoramento, 2011. http://hdl.handle.net/10451/5896.
  8. Batista, João Miguel Barroso. "Estudo do processo adaptativo em populações de Escherichia coli". Mestrado, 2009. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000571826.
  9. "Perfeito, Lília de Fátima Gomes. "Dynamics of adaptation in populations of E.coli"". Doutoramento, 2008.
  10. "Combadão, Jaime Manuel Pinto. "Models of natural selection in structured populations and in populations that fluctuate in size"". Doutoramento, 2008.

Outros

Outra produção
  1. Mutation, Selection and Genetic Interactions in Bacteria. 2010. Gordo, Isabel; Sousa, Ana.
    10.1002/9780470015902.a0022175
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021 Two modes of evolution shape diversity of a common gut commensal PopGen Vienna
Institute of Microbiology at ETH Zurich (Suiça)
2021 Two modes of evolution shape diversity of a common gut commensal EEB seminar
UCLA
2021 Two modes of evolution shape diversity of a common gut commensal Predicting Evolution
EMBO
2021 Evolution in E. coli Bilateral Workshop Instituto Gulbenkian de Ciência - Institut Pasteur
2021 Evolution in the mammalian gut SYMBNET seminar
2021 Evolution of commensal Escherichia coli strains in the mouse gut The Mobile Genome
EMBO
2021 Two modes of evolution shape diversity of a common gut commensal seminar series New voices in Infection Biology
Max Planck Institute for Infection Biology (MPIIB)
2020 Evolution in the gut Microbial Ecology and Evolution Virtual Conference
2020 Intra-species co-evolution in the mammalian intestine XVI ENBE
2019 Evolution of antibiotic resistance in the intestinal tract of mice seminar
CEDOC (Lisbon, Portugal)
2019 Evolutionary Mechanisms shaping the maintenance of Antibiotic Resistance in the gut microbiota Gordon Research Conference on Multidrug Efflux Systems
GRC (Lucca, Itália)
2019 Following the co-evolutionary dynamics of gut bacteria in real time GenomePT
(Vila do Conde)
2019 Eco-Evolutionary Dynamics of Bacteria Colonising the Gut Gordon Research Conference on Molecular Mechanisms in Evolution
GRC (Easton, Estados Unidos)
2019 Eco-evolutionary dynamics during Escherichia coli colonization of the mouse gut Joint 12th EBSA, 10th ICBP-IUPAP Biophysics Congress
(Madrid, Espanha)
2019 Eco-evolutionary dynamics during Escherichia coli colonization of the mouse gut Simpósio PDBMA
(Braga, Portugal)
2019 Eco-evolutionary dynamics during Escherichia coli colonization of the mouse gut seminar
University of Cologne (Alemanha)
2019 Eco-evolutionary dynamics during Escherichia coli colonization of the mouse gut Microbiotec
(Coimbra)
2018 Evolution of commensal bacteria in the gut, EMBO meeting Heidelberg, Germany
EMBO (Heidelberg, Alemanha)
2018 “Real time evolution of commensal bacteria in the mammalian gut.” 'Dynamics of biological systems: Modelling genetic, signalling and microbial networks
Solvay (Brussels, Bélgica)
2018 The role of epistasis on the fate of single and multiple resistances across environments.” Antibiotic Resistance Symposium
Biophysical Society (Stockholm, Suécia)
2018 Eco-evolutionary dynamics in the microbiota of the mammalian intestine Annual Meeting
Portuguese Society of Genetics (Porto, Portugal)
2018 Evolution in real time of gut commensal bacteria seminar
University of Bern (Bern, Suiça)
2018 Causes and Consequences of Antibiotic Resistance 7o Encontro MEFT – A Desafiar os Limites em Ciência e Tecnologia
IST (Lisbon, Portugal)
2018 Epistasis and the Fate Resistant Bacteria Across Environments cE3C meeting
FCUL (Lisbon, Portugal)
2018 Epistasis in antibiotic resistance NDPIA/IBA course on Antibiotics and Antimicrobial Resistance
Hjortviken Konferens (Gothenburg, Suécia)
2018 The role of epistasis on the fate of single and multiple resistances across environments Antibiotic Drug Targets and Resistance
Biozentrum Basel (Basel, Suiça)
2017 "Evolution of commensal bacteria in the gut" SMBE meeting, Kaziranga, India.
SMBE (Índia)
2017 “Evolution in the microbiota". 27th Solvay Conference on Physics - The Physics of Living Matter: Space, Time and Information in Biology, Brussels, Belgium. 27th Solvay Conference on Physics - The Physics of Living Matter: Space, Time and Information in Biology
(Brussels)
2017 Evolution of bacteria colonizing the intestinal tract: mutation versus horizontal gene transfer events as drivers of adaptation
FEMS (Valencia, Espanha)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2016 - 2020 The role of the gut microbiota in the subsistence of antibiotic resistance
Orientador
Biology (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 - 2016 The role of clonal interferences across genetic backgrounds and environments
Orientador
Biology (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 - 2016 Adaptation of Escherichia coli to the mouse gut
Orientador
Biology (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2007 - 2013 Role of biotic interactions in generating and maintaining biodiversity in Host- microbe interactions
Orientador
Biology (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008 - 2012 Chromosomal Structure: a selectable trait for evolution
Coorientador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2007 - 2012 The Impact of Genetic Interactions in Antibiotic Resistance
Orientador
Biology (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005 - 2008 Models of natural selection in structured populations and in populations that fluctuate in size
Orientador
Biology (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2004 - 2008 Dynamics of adaptation in populations of E.coli
Orientador
Biology (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2022 - Atual ESTN network meeting (2022/05/30 - 2022/06/01)
Mesa-redonda (Membro da Comissão Organizadora)
Bath College, Reino Unido
2022 - Atual ISEMPH 2022 Lisbon; Seventh Annual Meeting of the International Society for Evolution, Medicine, and Public Health (2022/07/05 - 2022/07/08)
Conferência (Coorganizador)
2015 - 2015 Forecasting Evolution, International Conference (2015 - 2015)
Conferência (Coorganizador)
Fundação Calouste Gulbenkian, Portugal
2006 - 2006 Mathematics in Biology II, summer school (2006 - 2006)
Oficina (workshop) (Presidente da Comissão Organizadora)
Instituto Gulbenkian de Ciência, Portugal
2006 - 2006 Coalescent Theory and its perspectives in Human Genetics (2006 - 2006)
Oficina (workshop)
Instituto Gulbenkian de Ciência, Portugal
2004 - 2004 Mathematics in Biology (2004 - 2004)
Oficina (workshop) (Presidente da Comissão Organizadora)
Instituto Gulbenkian de Ciência, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2024/10/22 - 2024/10/25 Evolving Microbes and Global Health Symposium Instituto Gulbenkian de Ciência

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2019 - Atual Postdoctoral Program Biology by Numbers
Diretor
Instituto Gulbenkian de Ciência, Portugal
2005 - 2009 PhD Program in Computational Biology
Membro
Instituto Gulbenkian de Ciência, Portugal
Distinções

Prémio

2020 Elected Member of the European Academy of Microbiology
Federation Of European Microbiological Societies, Países Baixos
2017 Elected EMBO Member
European Molecular Biology Laboratory, Alemanha
2015 Gilbert S. Omenn Prize
2014 PLoS Genetics Research Prize

Título

2020 Vice-Chair of ERC Panel LS8
European Commission Seventh Framework Programme for Research and Technological Development IDEAS The European Research Council, Bélgica
2019 Director of the Postdoctoral Programme "Biology by Numbers"
Instituto Gulbenkian de Ciência, Portugal
2018 Vice-director for Science
Fundação Calouste Gulbenkian, Portugal
2016 Non-North American Vice-President of the Society for the Study of Evolution

Outra distinção

2023 Elected Member of Appointment Committee "MPI for Evolutionary Biology"
Max-Planck-Institut für Evolutionsbiologie, Alemanha
2023 Member of Scientific Advisory Board of Max Planck Institute for Terrestrial Microbiology
Max-Planck-Institut für terrestrische Mikrobiologie, Alemanha
2021 Council Member of the European Society for Evolutionary Biology (ESEB)
2017 Council Member of the International Society for the Study of Evolution
2016 Panel Member Of ERC grant evaluation LS8
2014 Founder and President of the Portuguese Society for Evolutionary Biology
2014 Panel Member Of ERC grant evaluation LS8