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Osborne Francisco Xavier Almeida. Works in the area(s) of Medical and Health Sciences, with Neuroscience at the focus of his research. Until recently, his main work (mainly in rodents) concerned the mechanisms responsible for the disruption of neuronal circuits and anxiety. depression and cognition under the modulation of age, gender and environmental factors such as stress. In the last year, his attention has centered on the stigma associated with mental disorders.
Identificação

Identificação pessoal

Nome completo
Osborne Francisco Xavier Almeida

Nomes de citação

  • Almeida, Osborne F. X.

Identificadores de autor

Ciência ID
D21F-C575-E519
ORCID iD
0000-0001-7331-6928

Endereços de correio eletrónico

  • osa@psych.mpg.de (Profissional)
  • OsborneAlmeida@med.uminho.pt (Profissional)

Telefones

Telefone
  • (0049) 89 Ext.: 2722541 (Profissional)
Telemóvel
  • (0049) 176 Ext.: 99700834 (Profissional)

Moradas

  • Max Planck Institute of Psychiatry, Kraepelinstrasse 2-12, 80804, Schwabing, Munich, Alemanha (Profissional)
  • School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Profissional)
  • Petra Kelly Strasse 22, 80797, Munich, Munich, Alemanha (Pessoal)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês (Idioma materno)
Alemão Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1)
Português Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
1993 - 1995
Concluído
 Habilitation (Dottorato di Ricerca)
Ludwig Maximilians Universität München Department Biologie I, Alemanha
"Die Modulation des neuroendocrinen Hypothalamus durch Umwelteinflüsse und ühysiologische Stimuli" (TESE/DISSERTAÇÃO)
1978 - 1982
Concluído
 PhD (Doctor of Philosophy)
The University of Edinburgh, Reino Unido
"Melatonin and the control of seasonal breeding in the Soay ram" (TESE/DISSERTAÇÃO)
1977 - 1979
Concluído
 Zoology (Master)
Cardiff University, Reino Unido
"Thyroid Function in the Japanese Quail (Coturnix coturnix japonica)" (TESE/DISSERTAÇÃO)
1973 - 1976
Concluído
 Comparative Physiology (Bachelor)
Queen Mary University of London, Reino Unido
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1982/11/01 - 1984/04/30 Investigador visitante (Investigação) National Institutes of Health, Estados Unidos
National Institute of Child Health and Human Development, Estados Unidos
1981/09/01 - 1982/09 Pós-doutorado (Investigação) Medical Research Council, Reino Unido
The University of Edinburgh MRC Centre for Reproductive Health, Reino Unido

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/09/01 - Atual Professor (Part-time) Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/04/01 - Atual Guest Scientist Max-Planck-Institut für Psychiatrie, Alemanha
1987/09/01 - 1990/12/31 Lecturer Ludwig-Maximilians-Universitat Munchen, Alemanha
institut für Pharakologie und Toxikologie, Tierärtzliche Fakultat der Universität München, Alemanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
1984/05/01 - 2020/03/31 Professor/Group Leader Max-Planck-Institut für Psychiatrie, Alemanha
2019/04/01 - 2019/05/31 Guest Professor China Medical University (Liaoning), China
2017/09/01 - 2017/11/15 Guest Professor Gakushuin Daigaku, Japão
1996/01/01 - 1996/06/30 Guest Professor Universidade do Porto Faculdade de Medicina Dentária, Portugal
Projetos

Bolsa

Designação Financiadores
2014 - 2018 BM1402 - Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE)
BM-1402
Investigador responsável
2000 - 2004 Steroid regulation of Alzheimer's disease proteins
SPP-TP
Investigador responsável
Max-Planck-Institut für Psychiatrie, Alemanha
 Deutsche Forschungsgemeinschaft
Concluído
1984 - 1992 Adaptive mechanisms in neural systrems - endocrine regulation of opioid neruobiology
SFB 220/TP
Investigador responsável
Max-Planck-Institut für Psychiatrie, Alemanha
 Deutsche Forschungsgemeinschaft

Projeto

Designação Financiadores
2011 - 2015 Switchbox: Maintaining health in old age through homeostasis
259772
Investigador responsável
Max-Planck-Institut für Psychiatrie, Alemanha
 European Commission
Concluído
2005 - 2011 Nuclear Receptors in Development and Aging (CRESCENDO)
018652
Investigador responsável
Max-Planck-Institut für Psychiatrie, Alemanha
 European Commission
1999 - 2003 Neurocoregulators - Coactivators and Corepressors of Nuclear Hormone Receptors
QLG3-CT-2000- 00844
Investigador responsável
Max-Planck-Institut für Psychiatrie, Alemanha
 European Commission
Concluído
Produções

Publicações

Artigo em revista
  1. Almeida, Osborne; Sousa, Nuno. Autor correspondente: Almeida, Osborne. "Leveraging Neuroscience to Fight Stigma Around Mental Health". Frontiers in Behavioral Neuroscience 15 (2022): 812184.
    Acesso aberto • No prelo
  2. Susanne Moosecker; Anna Pissioti; Este Leidmaa; Mazen R. Harb; Chrysoula Dioli; Nils C. Gassen; Shuang Yu; et al. "Brain Expression, Physiological Regulation and Role in Motivation and Associative Learning of Peroxisome Proliferator-activated Receptor ¿.". Neuroscience 479 (2021): 91-106. 10.1016/j.neuroscience.2021.10.029.
    Acesso aberto • 10.1016/j.neuroscience.2021.10.029
  3. Monteiro-Fernandes, D.; Sousa, N.; Almeida, O.F.X.; Sotiropoulos, I.. "Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain". Neuroscience 454 (2021): 140-150. 10.1016/j.neuroscience.2020.05.049.
    10.1016/j.neuroscience.2020.05.049
  4. Este Leidmaa; Mary Gazea; Alexandre V. Patchev; Anna Pissioti; Nils Christian Gassen; Mayumi Kimura; Zsolt Liposits; Imre Kallo; Osborne F. X. Almeida. "Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus". Acta Physiologica (2020): https://doi.org/10.1111/apha.13345.
    10.1111/apha.13345
  5. Almeida, Osborne. "The Arctic/Swedish APP mutation alters the impact of chronic stress on cognition in mice.". The European journal of neuroscience (2019): https://doi.org/10.1111/ejn.14500.
    10.1111/ejn.14500
  6. Almeida, Osborne. "Activated PPAR¿ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity.". Frontiers in cellular neuroscience (2019): http://europepmc.org/articles/PMC6584807.
    10.3389/fncel.2019.00239
  7. Almeida, Osborne. "Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes.". European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2018): https://doi.org/10.1016/j.euroneuro.2018.11.1107.
    10.1016/j.euroneuro.2018.11.1107
  8. Almeida, Osborne. "Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory.". Frontiers in neuroscience (2018): http://europepmc.org/articles/PMC5838015.
    10.3389/fnins.2018.00124
  9. Almeida, Osborne. "Restoring Serotonergic Homeostasis in the Lateral Hypothalamus Rescues Sleep Disturbances Induced by Early-Life Obesity.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2017): http://europepmc.org/articles/PMC6596113.
    10.1523/JNEUROSCI.1333-17.2017
  10. Almeida, Osborne. "Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.". EBioMedicine (2017): http://europepmc.org/articles/PMC5478209.
    10.1016/j.ebiom.2017.05.012
  11. Almeida, Osborne. "The nucleus reuniens: a key node in the neurocircuitry of stress and depression.". Molecular psychiatry (2017): http://europepmc.org/articles/PMC5822458.
    10.1038/mp.2017.55
  12. Almeida, Osborne. "Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria.". Cerebral cortex (New York, N.Y. : 1991) (2017): https://doi.org/10.1093/cercor/bhw057.
    10.1093/cercor/bhw057
  13. Almeida, Osborne. "Antidepressant responsiveness in adulthood is permanently impaired after neonatal destruction of the neurogenic pool.". Translational psychiatry (2017): http://europepmc.org/articles/PMC5545723.
    10.1038/tp.2016.255
  14. Almeida, Osborne. "Glucose intolerance after chronic stress is related with downregulated PPAR-¿ in adipose tissue.". Cardiovascular diabetology (2016): http://europepmc.org/articles/PMC4990862.
    10.1186/s12933-016-0433-2
  15. Almeida, Osborne. "Tau protein is essential for stress-induced brain pathology.". Proceedings of the National Academy of Sciences of the United States of America (2016): http://europepmc.org/articles/PMC4932951.
    10.1073/pnas.1600953113
  16. Almeida, Osborne. "Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration.". Neural plasticity (2016): http://europepmc.org/articles/PMC4806285.
    10.1155/2016/6391686
  17. Almeida, Osborne. "Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is an Early Event in the Actions of Soluble Amyloid-ß(1-40) Oligomers on Hippocampal Neurons.". Journal of Alzheimer's disease : JAD (2016): https://doi.org/10.3233/JAD-150942.
    10.3233/jad-150942
  18. Li, Yan; Chang, Lirong; Song, Yizhi; Gao, Xianghong; Roselli, Francesco; Liu, Jinping; Zhou, Wei; et al. "Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-beta(1-40) in Hippocampal Cells". Journal of Alzheimers Disease 54 1 (2016): 135-148. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000383838400014&KeyUID=WOS:000383838400014.
    10.3233/jad-160297
  19. Almeida, Osborne. "Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.". Nature communications (2015): http://europepmc.org/articles/PMC4703892.
    10.1038/ncomms10216
  20. Almeida, Osborne. "Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression.". Translational psychiatry (2015): http://europepmc.org/articles/PMC4490283.
    10.1038/tp.2015.72
  21. Almeida, Osborne. "Neuropsychology of Neuroendocrine Dysregulation after Traumatic Brain Injury.". Journal of clinical medicine (2015): http://europepmc.org/articles/PMC4470216.
    10.3390/jcm4051051
  22. Almeida, Osborne. "Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress.". Epigenetics (2015): http://europepmc.org/articles/PMC4622987.
    10.1080/15592294.2015.1017199
  23. Almeida, Osborne. "Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology.". Journal of Alzheimer's disease : JAD (2015): https://doi.org/10.3233/JAD-140693.
    10.3233/jad-140693
  24. Almeida, Osborne. "Selective inhibitors of the FK506-binding protein 51 by induced fit.". Nature chemical biology (2014): https://doi.org/10.1038/nchembio.1699.
    10.1038/nchembio.1699
  25. Almeida, Osborne. "Altered motivation masks appetitive learning potential of obese mice.". Frontiers in Behavioral Neuroscience (2014): http://europepmc.org/articles/PMC4214228.
    10.3389/fnbeh.2014.00377
  26. Almeida, Osborne; Thomas Fink; Katrin Walther; Nuno Sousa; Osborne F.X. Almeida; Zihl Josef; Antonia Schmid. "Cognitive Reserve in the Healthy Elderly: Cognitive and Psychological Factors". ScienceOpen Research (2014): http://dx.doi.org/10.14293/s2199-1006.1.sor-socsci.a5kkma.v2.
    10.14293/s2199-1006.1.sor-socsci.a5kkma.v2
  27. Almeida, Osborne. "Reward components of feeding behavior are preserved during mouse aging.". Frontiers in aging neuroscience (2014): http://europepmc.org/articles/PMC4165288.
    10.3389/fnagi.2014.00242
  28. Almeida, Osborne. "Androgen receptor-mediated regulation of adrenocortical activity in the sand rat, Psammomys obesus.". Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology (2014): https://doi.org/10.1007/s00360-014-0859-3.
    10.1007/s00360-014-0859-3
  29. Almeida, Osborne. "Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.". Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2014): http://europepmc.org/articles/PMC4443946.
    10.1038/npp.2014.176
  30. Almeida, Osborne. "Pavlovian conditioning and cross-sensitization studies raise challenges to the hypothesis that overeating is an addictive behavior.". Translational psychiatry (2014): http://europepmc.org/articles/PMC4012290.
    10.1038/tp.2014.28
  31. Almeida, Osborne. "Day and night: diurnal phase influences the response to chronic mild stress.". Frontiers in Behavioral Neuroscience (2014): http://europepmc.org/articles/PMC3954061.
    10.3389/fnbeh.2014.00082
  32. Almeida, Osborne. "Early-life stress reduces DNA methylation of the Pomc gene in male mice.". Endocrinology (2014): https://doi.org/10.1210/en.2013-1868.
    10.1210/en.2013-1868
  33. Almeida, Osborne. "Neuropathology of stress.". Acta neuropathologica (2013): http://europepmc.org/articles/PMC3889685.
    10.1007/s00401-013-1223-5
  34. Almeida, Osborne. "The future is now: early life events preset adult behaviour.". Acta physiologica (Oxford, England) (2013): https://doi.org/10.1111/apha.12140.
    10.1111/apha.12140
  35. Almeida, Osborne. "Non-receptor-tyrosine kinases integrate fast glucocorticoid signaling in hippocampal neurons.". The Journal of biological chemistry (2013): http://europepmc.org/articles/PMC3745320.
    10.1074/jbc.M113.470146
  36. Almeida, Osborne. "Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens.". Translational psychiatry (2013): http://europepmc.org/articles/PMC3693402.
    10.1038/tp.2013.39
  37. Almeida, Osborne. "Sustained remission from depressive-like behavior depends on hippocampal neurogenesis.". Translational psychiatry (2013): http://europepmc.org/articles/PMC3566721.
    10.1038/tp.2012.141
  38. Almeida, Osborne. "Mood is a key determinant of cognitive performance in community-dwelling older adults: a cross-sectional analysis.". Age (Dordrecht, Netherlands) (2012): http://europepmc.org/articles/PMC3776101.
    10.1007/s11357-012-9482-y
  39. Almeida, Osborne. "Disconnection and reconnection: the morphological basis of (mal)adaptation to stress.". Trends in neurosciences (2012): https://doi.org/10.1016/j.tins.2012.08.006.
    10.1016/j.tins.2012.08.006
  40. Almeida, Osborne. "Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice.". Brain : a journal of neurology (2012): https://doi.org/10.1093/brain/aws195.
    10.1093/brain/aws195
  41. Almeida, Osborne. "Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode.". The European journal of neuroscience (2012): https://doi.org/10.1111/j.1460-9568.2012.08262.x.
    10.1111/j.1460-9568.2012.08262.x
  42. Bettscheider, Marc; Kuczynska, Arleta; Almeida, Osborne; Spengler, Dietmar. "Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain". Journal of Visualized Experiments 65 (2012): http://dx.doi.org/10.3791/3938.
    10.3791/3938
  43. Almeida, Osborne. "Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids.". Molecular psychiatry (2011): https://doi.org/10.1038/mp.2011.126.
    10.1038/mp.2011.126
  44. Almeida, Osborne. "Citalopram-mediated anxiolysis and differing neurobiological responses in both sexes of a genetic model of depression.". Neuroscience (2011): https://doi.org/10.1016/j.neuroscience.2011.07.077.
    10.1016/j.neuroscience.2011.07.077
  45. Almeida, Osborne. "CDK5 is essential for soluble amyloid ß-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.". PloS one (2011): http://europepmc.org/articles/PMC3146526.
    10.1371/journal.pone.0023097
  46. Almeida, Osborne. "Glucocorticoid regulation of astrocytic fate and function.". PloS one (2011): http://europepmc.org/articles/PMC3141054.
    10.1371/journal.pone.0022419
  47. Almeida, Osborne. "Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2011): https://doi.org/10.1523/JNEUROSCI.0730-11.2011.
    10.1523/jneurosci.0730-11.2011
  48. Almeida, Osborne. "Differential regulation and function of 5'-untranslated GR-exon 1 transcripts.". Molecular endocrinology (Baltimore, Md.) (2011): http://europepmc.org/articles/PMC5417247.
    10.1210/me.2010-0436
  49. Sotiropoulos, Ioannis; Catania, Caterina; Pinto, Lucilia G.; Silva, Rui; Pollerberg, G. Elizabeth; Takashima, Akihiko; Sousa, Nuno; Almeida, Osborne F. X.. "Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits". Journal of Neuroscience 31 21 (2011): 7840-7847. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000290956400026&KeyUID=WOS:000290956400026.
    10.1523/JNEUROSCI.0730-11.2011
  50. Almeida, Osborne. "Potential programming of dopaminergic circuits by early life stress.". Psychopharmacology (2010): https://doi.org/10.1007/s00213-010-2085-3.
    10.1007/s00213-010-2085-3
  51. Almeida, Osborne. "Corticosteroids: way upstream.". Molecular brain (2010): http://europepmc.org/articles/PMC2841592.
    10.1186/1756-6606-3-2
  52. Almeida, Osborne. "Stress and the neuroendocrinology of anxiety disorders.". Current topics in behavioral neurosciences (2010):
  53. Almeida, Osborne. "Amyloid-ß induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors.". Journal of Alzheimer's disease : JAD (2010): https://doi.org/10.3233/JAD-2010-100948.
    10.3233/jad-2010-100948
  54. Almeida, Osborne. "Depletion of the neural precursor cell pool by glucocorticoids.". Annals of neurology (2010): https://doi.org/10.1002/ana.21812.
    10.1002/ana.21812
  55. Liu, Jinping; Chang, Lirong; Roselli, Francesco; Almeida, Osborne F. X.; Gao, Xiulai; Wang, Xiaomin; Yew, David T.; Wu, Yan. "Amyloid-beta Induces Caspase-Dependent Loss of PSD-95 and Synaptophysin Through NMDA Receptors". Journal of Alzheimers Disease 22 2 (2010): 541-556. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000284309200015&KeyUID=WOS:000284309200015.
    10.3233/JAD-2010-100948
  56. Almeida, Osborne. "Dynamic DNA methylation programs persistent adverse effects of early-life stress.". Nature neuroscience (2009): https://doi.org/10.1038/nn.2436.
    10.1038/nn.2436
  57. Almeida, Osborne. "Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.". PloS one (2009): http://europepmc.org/articles/PMC2695780.
    10.1371/journal.pone.0006011
  58. Almeida, Osborne. "A trans-dimensional approach to the behavioral aspects of depression.". Frontiers in Behavioral Neuroscience (2009): http://europepmc.org/articles/PMC2634526.
    10.3389/neuro.08.001.2009
  59. Almeida, Osborne. "Glucocorticoids and neuro- and behavioural development.". Seminars in fetal & neonatal medicine (2008): https://doi.org/10.1016/j.siny.2008.11.002.
    10.1016/j.siny.2008.11.002
  60. Almeida, Osborne. "The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling.". Molecular psychiatry (2008): https://doi.org/10.1038/mp.2008.119.
    10.1038/mp.2008.119
  61. Almeida, Osborne. "Stress and glucocorticoid footprints in the brain-the path from depression to Alzheimer's disease.". Neuroscience and biobehavioral reviews (2008): https://doi.org/10.1016/j.neubiorev.2008.05.007.
    10.1016/j.neubiorev.2008.05.007
  62. Almeida, Osborne. "Dissociation of the morphological correlates of stress-induced anxiety and fear.". The European journal of neuroscience (2008): https://doi.org/10.1111/j.1460-9568.2008.06112.x.
    10.1111/j.1460-9568.2008.06112.x
  63. Almeida, Osborne. "The stressed prefrontal cortex. Left? Right!". Brain, behavior, and immunity (2008): https://doi.org/10.1016/j.bbi.2008.01.005.
    10.1016/j.bbi.2008.01.005
  64. Almeida, Osborne. "Effects of altered corticosteroid milieu on rat hippocampal neurochemistry and structure--an in vivo magnetic resonance spectroscopy and imaging study.". Journal of psychiatric research (2008): https://doi.org/10.1016/j.jpsychires.2007.10.003.
    10.1016/j.jpsychires.2007.10.003
  65. SOTIROPOULOS, I; CATANIA, C; RIEDEMANN, T; FRY, JP; BREEN, KC; MICHAELIDIS, TM; ALMEIDA, OFX. "Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau". Journal of Neurochemistry 107 2 (2008): 385-397. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000259949900008&KeyUID=WOS:000259949900008.
    10.1111/j.1471-4159.2008.05613.x
  66. Almeida, Osborne. "Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: the role of glycogen-synthase-kinase-3beta.". Neuroscience (2007): https://doi.org/10.1016/j.neuroscience.2007.12.026.
    10.1016/j.neuroscience.2007.12.026
  67. Almeida, Osborne. "Lithium prevents stress-induced reduction of vascular endothelium growth factor levels.". Neuroscience letters (2007): https://doi.org/10.1016/j.neulet.2007.09.062.
    10.1016/j.neulet.2007.09.062
  68. Almeida, Osborne. "The amyloidogenic potential and behavioral correlates of stress.". Molecular psychiatry (2007): https://doi.org/10.1038/sj.mp.4002101.
    10.1038/sj.mp.4002101
  69. Almeida, Osborne. "Neuronal actions of glucocorticoids: focus on depression.". The Journal of steroid biochemistry and molecular biology (2007): https://doi.org/10.1016/j.jsbmb.2007.09.014.
    10.1016/j.jsbmb.2007.09.014
  70. Almeida, Osborne. "Corticosteroid receptors and neuroplasticity.". Brain research reviews (2007): https://doi.org/10.1016/j.brainresrev.2007.06.007.
    10.1016/j.brainresrev.2007.06.007
  71. Almeida, Osborne. "Neurodevelopment milestone abnormalities in rats exposed to stress in early life.". Neuroscience (2007): https://doi.org/10.1016/j.neuroscience.2007.04.007.
    10.1016/j.neuroscience.2007.04.007
  72. Almeida, Osborne. "Hormones and adult neurogenesis in mammals.". Expert review of endocrinology & metabolism (2007): https://doi.org/10.1586/17446651.2.2.261.
    10.1586/17446651.2.2.261
  73. Almeida, Osborne. "Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor.". Molecular and cellular endocrinology (2007): https://doi.org/10.1016/j.mce.2007.01.010.
    10.1016/j.mce.2007.01.010
  74. Almeida, Osborne. "Programming effects of antenatal dexamethasone in the developing mesolimbic pathways.". Synapse (New York, N.Y.) (2007): https://doi.org/10.1002/syn.20341.
    10.1002/syn.20341
  75. CERQUEIRA, JJ; MAILLIET, F; ALMEIDA, OFX; JAY, TM; SOUSA, N; Almeida, Osborne. "The prefrontal cortex as a key target of the maladaptive response to stress". Journal of Neuroscience 27 11 (2007): 2781-2787. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000245103600006&KeyUID=WOS:000245103600006.
    10.1523/JNEUROSCI.4372-06.2007
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Capítulo de livro
  1. Sotiropoulos, Ioannis; Silva, Joana M.; Gomes, Patricia; Sousa, Nuno; Almeida, Osborne F. X.. "Stress and the Etiopathogenesis of Alzheimer’s Disease and Depression". In Advances in Experimental Medicine and Biology, 241-257. Springer Singapore, 2019.
    10.1007/978-981-32-9358-8_20
  2. Almeida, Osborne. "INTRAHYPOTHALAMIC NEUROENDOCRINE ACTIONS OF CORTICOTROPIN-RELEASING FACTOR". 151-172. 1993.
  3. Almeida, Osborne. "GENERATION OF MELATONIN RHYTHMS". 129-148. 1985.
  4. Almeida, Osborne. "MELATONIN AND MALIGNANT DISEASE". 284-299. 1985.
Livro
  1. Patchev, V. K.; Almeida, Osborne F. X.. Steroid-Hormone-Dependent Organization of Neuroendocrine Functions. Austin, TX, Estados Unidos: R.G. Landes Bioscience. 1999.
    Publicado
  2. Neurobiology of Opioids. Springer. 1991.
    Publicado • Editor
Relatório
  1. Almeida, Osborne. 1999. European Neuroendocrine Association--ninth meeting. 3-7 September 1999, Odense, Denmark..
  2. Almeida, Osborne. 1999. Steroid action in neural and neuroendrocine systems..
  3. Almeida, Osborne. 1987. Corticotropin releasing hormone effects on peptidergic neurons of the hypothalamus..
  4. Almeida, Osborne. 1986. Inhibition of LH release by CRF may be partially mediated through hypothalamic beta-endorphin release..
  5. Almeida, Osborne. 1986. Regulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (CRF)..

Propriedade Intelectual

Patente
  1. 1999. "D-arginine for the treatment of neorodegenerative diseases". Alemanha.
    Permitida

Outros

Outra produção
  1. Early and specific detection of Alzheimer’s disease – more than a (virtual) reality?. 2024. Osborne Almeida. https://doi.org/10.1093/braincomms/fcae014.
    10.1093/braincomms/fcae014
Atividades

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
1995 PhD Juries: Munich (Ludwig Maximilian and Technical Universities), Minho, Paris, Strasbourg, Tartu, Cracow, Singapore, Algiers, Assiut, Stockholm (Karolinska Institute), Heidelberg, Berlin (Charite), Kings College London, Open University (UK), Bristol Multiple (Doutoramento)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - Atual Aging Brain - Editor-in-Chief (2589-9589) Elsevier
2007 - 2022 Frontiers in Behavioral Neuroscience (1662453X, 16624548)
1991 - 1999 Neuroendocrinology (0028-3835) Karger
1989 - 1994 Journal of Neuroendocrinology (1365-2826) WIley

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2012 - Atual Hong Kong Research Grants Council - neuroscience, neurology and psychiatry project proposal evaluation
Avaliador
2009 - Atual European Union Project Proposals in FP6, FP7, including Assessor of 2 Large-Scale Project Mid-Term and Final Reports
Avaliador
2005 - Atual Fundação para a Ciência e a Tecnologia (FCT) Evaluation Committees (Portuguese University Research Units, Associated Laboratories and Graduate Schools)
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal
2005 - Atual Italian Ministry for University & Industrial Research - grant proposals in neuroscience, neurology, psychiatry and reproductive sciences
Avaliador
2011 - 2019 Agence national de la rechércé (ANR), France: Member of Advisory Panels on Basic Neuroscience, Translational Medicine (covering PIs, Young Researchers, International Collaborations, Industrial Collaborations)
Membro
2010 - 2018 European Union FP6, FP7 - Marie Curie Programs
Especialista
2012 - 2013 French HCERES - High Council for Evaluation of Research and Higher Education, Scientific Advisory Board Member
Membro
 HCERES - High Council for Evaluation of Research and Higher Education, França

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2019 - 2021 United Kingdom Research & Innovation Council - Neuroscience & Behavior Working Group
2015 - 2017 Servier Research Laboratories, Paris - Advisor for Neuropharmacology Institut Servier SAS, França
2003 - 2013 Open University, UK - Affiliated Research Center at Max Planck Institute of Psychiatry, Munich Max-Planck-Institut für Psychiatrie, Alemanha

The Open University, Reino Unido
2007 - 2009 Max Planck Institute of Psychiatry Ombudsperson Max-Planck-Institut für Psychiatrie, Alemanha

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/10 - 2021/11 The Challenge of Stigma in Mental Health (Outros) School of Medicine, University of Minho, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2022/03/01 - Atual la Caixa¿ Foundation - Neuroscience Panel
2022 - Atual Agence national de la rechércé (ANR), France: Translational Medicine Advisory Panel Member (covering PIs, Young Researchers, International Collaborations, Industrial Collaborations)
Membro
2020 - Atual National Research Center, Poland, Advisory Panel Member, Life Science and Humanities, Social Sciences and Art Domain
Consultor
 National Science Center, Polónia
2016 - Atual BIAL Foundation, Scientific Council
Membro
2014 - 2018 COST BM1402 - European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE)
Membro
 European Cooperation in Science and Technology, Bélgica
2003 - 2009 Max Planck Society Scientific Council (Biomedical Sciences Section)
Membro
 Max-Planck-Gesellschaft zur Förderung der Wissenschaften, Alemanha
2004 - 2004 Fundação para a Ciência e a Tecnologia (FCT; Portuguese Science and Technology Foundation) (Cellular & Molecular Biology)
1999 - 2003 European Union Project Neurocoregulators, in FP5
Coordenador
 European Commission, Bélgica
Distinções

Prémio

2019 Visiting Professor
China Medical University, China
2019 Gakushuin University Presidential Research Fellow
Gakushuin Daigaku Rigakubu Butsuri Gakka Daigakuin Shizen Kagaku Kenkyuka Butsurigaku Senko, Japão
1996 MIFEK-KIRSCHNER FELLOW at Porto Medical School
Max-Planck-Institut für Psychiatrie, Alemanha
1982 Fulbright Senior Research Fellow
Fulbright Association, Estados Unidos
1982 Fogarty International Fellow
John E Fogarty International Center, Estados Unidos
1978 UK Medical Research Council Fellowship
Medical Research Council, Reino Unido
1977 Sir Richard Stapley Bursar
Sir Richard Stapley Educational Trust, Emiratos Árabes Unidos

Título

2007 Guest professor
Universidade do Minho Escola de Medicina, Portugal
1999 Guest Professor - Centre national de la recherché scientifique (CNRS), MNHN, Paris, FR
Centre National de la Recherche Scientifique, França
1995 Scientific Consultant
Japanese society for the Promotion of Science, Japão

Outra distinção

2018 Foreign Member
Colombian society of Biological Psychiatry, Colômbia