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Ana Maria Sequeira Cardoso concluded her PhD in Biosciences, specialization in Biochemistry, in 2014 from the University of Coimbra (Faculty of Sciences and Technology), her MSc in Biochemistry in 2009 from the University of Coimbra (Faculty of Sciences and Technology) and her BSc in Biochemistry in 2007 from the University of Coimbra (Faculty of Sciences and Technology). She is a researcher in CIBB (former CNC.IBILI), with 31 articles published in specialized journals, and four book chapters, summing 594 citations, which rendered her an h-index of 15 (Scopus). MAIN SCIENTIFIC AREA OF RESEARCH Study of the molecular mechanisms underlying glioblastoma malignancy. Development of RNA-based strategies towards glioblastoma therapy. Study of the role of non-protein coding RNAs in the regulation of energy metabolism in glioblastoma cells. Evaluation of the impact of gene therapy approaches targeting the expression of long non-coding RNAs and microRNAs involved in the metabolic phenotype of cancer cells, which is intimately connected with stem-like features displayed by tumors, in glioblastoma cell invasion ability and their sensitization to chemotherapeutic drugs. Tridimensional in vitro models of glioblastoma cells (spheroids and organoids) to test RNA-mediated therapeutic approaches that more closely resemble the responses of glioblastoma tumors in their physiological environment. Human cerebral organoids to study brain diseases with genetic etiology, such as frontotemporal dementia (FTD), and autism spectrum disorders (ASD). OTHER SCIENTIFIC AREAS OF INTEREST Study of miRNAs involved in the immune response in Alzheimer's Disease (AD) patients, including peripheral blood mononuclear cell isolation, identification, determination of immune activity, chemotaxis and phagocytosis, and correlation with differential expression of immune-related microRNAs. Attention deficit and hyperactivity disorder (ADHD) correlation with immune dysfunction in early childhood; assessment of development of ADHD phenotype in murine asthma models. Development of nucleic acid delivery systems, based on lipids, gemini surfactants, cell-penetrating peptides and thermoresponsive polymers, for gene therapy. Study of the biophysical properties of nucleic acid delivery systems and establishment of correlations between their biological activity, their structural characteristics and their interaction with biological or model membranes. Gene therapy directed towards mitochondria.
Identificação

Identificação pessoal

Nome completo
Ana Maria Sequeira Cardoso

Nomes de citação

  • Cardoso, A.M.

Identificadores de autor

Ciência ID
D113-0602-8986
ORCID iD
0000-0002-1629-4782
Researcher Id
D-6563-2014
Scopus Author Id
47961021900

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biofísica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2014
Concluído
Doutoramento em Biociências, especialização em Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Nucleic Acid Delivery Systems: From Biophysics to Biological Activity" (TESE/DISSERTAÇÃO)
Aprovada com distinção e louvor por unanimidade
2009
Concluído
Mestrado em Bioquímica (2º ciclo de Bolonha) (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Biophysical characterization of Gemini-based lipoplexes with different levels of biological activity" (TESE/DISSERTAÇÃO)
18
2007
Concluído
Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/01/15 - Atual Investigador (Investigação) CNC.IBILI, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2015/01/02 - 2019/01/14 Post-Doc Researcher CNC.IBILI, Portugal
2010/05/01 - 2014/12/23 Ph.D. student CNC.IBILI, Portugal
2009/09/01 - 2010/04/30 Research Technician CNC.IBILI, Portugal
Projetos

Bolsa

Designação Financiadores
2015 - 2019/01/14 Targeting non-coding RNAs involved in the regulation of glycolysis/oxidative phosphorylation of glioblastoma cells towards tumor sensitization to chemotherapy
SFRH/BPD/99613/2014
Bolseiro de Pós-Doutoramento
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2014/04/30 Interaction of Lipoplexes with Cellular Membranes: a Biophysical Approach to Gene Delivery
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/103001/PT
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2009 - 2010/04/30 Development of a novel approach for anti-tumoral therapy based on the S4(13)-PV cell penetrating peptide to improve the intracellular delivery of therapeutic proteins and nucleic acids
PTDC/BIO/65627/2006
Bolseiro de Técnico de Investigação
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia

Outro

Designação Financiadores
2021 - 2023/12/31 Disease modelling of frontotemporal dementia in human brain organoids
PTDC/MEC-NEU/4814/2020
Investigador
Fundação para a Ciência e a Tecnologia
2019 - 2020/12/31 Projecto estratégico UID/NEU/04539/2019
UID/NEU/04539/2019
Investigador
2017 - 2020/12/31 BrainHealth2020 - Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders
CENTRO-01-0145-FEDER-000008
Investigador
2017 - 2019/12/31 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
POCI-01-0145-FEDER-016390
Investigador
2016 - 2018/12/31 A lipidomic and miRNA-based strategy for glioblastoma treatment
A03/2016
Investigador
2013 - 2015/12/31 Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid­based nanosystem for systemic delivery
PTDC/DTP-FTO/0265/2012
Investigador
2013 - 2014/12/31 Projecto estratégico CNC/UC: PEst­C/SAU/LA0001/2013 – LA1
CNC/UC: PEst­C/SAU/LA0001/2013 – LA1
Investigador
2011 - 2012/12/31 Projecto estratégico CNC/UC: PEst­C/SAU/LA0001/2011 - LA1
CNC/UC: PEst­C/SAU/LA0001/2011 - LA1
Investigador
CNC.IBILI, Portugal
Produções

Publicações

Artigo em revista
  1. Cardoso, Ana M; Morais, Catarina M; Sousa, Madalena; Rebelo, Olinda; Tão, Hermínio; Barbosa, Marcos; Pedroso de Lima, Maria C; Jurado, Amália S. "MiR-200c-based metabolic modulation in glioblastoma cells as a strategy to overcome tumor chemoresistance". Human Molecular Genetics 30 23 (2021): 2315-2331. http://dx.doi.org/10.1093/hmg/ddab193.
    10.1093/hmg/ddab193
  2. Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512-111512. https://doi.org/10.1016/j.mad.2021.111512.
    10.1016/j.mad.2021.111512
  3. Cardoso, A.M.; Morais, C.M.; Rebelo, O.; Tão, H.; Barbosa, M.; Pedroso de Lima, M.C.; Jurado, A.S.. "Downregulation of long non-protein coding RNA MVIH impairs glioblastoma cell proliferation and invasion through a miR-302a-dependent mechanism". Human Molecular Genetics (2021): http://dx.doi.org/10.1093/hmg/ddab009.
    10.1093/hmg/ddab009
  4. Cardoso, A.M.; Morais, C.M.; Pena, F.; Marante, T.; Cunha, P.P.; Jurado, A.S.; Pedroso de Lima, M.C.. "Differentiation of glioblastoma stem cells promoted by miR-128 or miR-302a overexpression enhances senescence-associated cytotoxicity of axitinib". Human Molecular Genetics (2021): http://dx.doi.org/10.1093/hmg/ddab011.
    10.1093/hmg/ddab011
  5. Faria, Rúben; Albuquerque, Tânia; Neves, Ana R.; Bhatt, Himanshu; Biswas, Swati; Cardoso, Ana M.; Pedroso de Lima, Maria C.; Jurado, Amália S.; Costa, Diana. "Physicochemical characterization and targeting performance of triphenylphosphonium nano-polyplexes". Journal of Molecular Liquids 316 (2020): 113873. http://dx.doi.org/10.1016/j.molliq.2020.113873.
    10.1016/j.molliq.2020.113873
  6. Morais, Catarina M.; Cardoso, Ana M.; Aguiar, Luísa; Vale, Nuno; Nóbrega, Clévio; Zuzarte, Mónica; Gomes, Paula; Pedroso de Lima, Maria C.; Jurado, Amália S.. "Lauroylated Histidine-Enriched S413-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells". Pharmaceutical Research 37 10 (2020): http://dx.doi.org/10.1007/s11095-020-02904-x.
    10.1007/s11095-020-02904-x
  7. Silva, Francisco; Paulo, António; Pallier, Agnès; Même, Sandra; Tóth, Éva; Gano, Lurdes; Marques, Fernanda; et al. "Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics". Materials 13 3 (2020): 513. http://dx.doi.org/10.3390/ma13030513.
    Publicado • 10.3390/ma13030513
  8. Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de Almeida, Luís; et al. "MiRNA-31 improves cognition and abolishes amyloid-ß pathology by targeting APP and BACE1 in an animal model of Alzheimer’s disease". Molecular Therapy - Nucleic Acids (2020): http://dx.doi.org/10.1016/j.omtn.2020.01.010.
    Aceite para publicação • 10.1016/j.omtn.2020.01.010
  9. Catarina M Morais; Pedro P Cunha; Tânia Melo; Ana M Cardoso; Pedro Domingues; M Rosário Domingues; Maria C Pedroso de Lima; Amália S Jurado. "Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma". Human Molecular Genetics (2019): https://doi.org/10.1093/hmg/ddz152.
    10.1093/hmg/ddz152
  10. Ana M S Cardoso; Madalena Sousa; Catarina M Morais; Liliana R Oancea-Castillo; Anne Régnier-Vigouroux; Olinda Rebelo; Hermínio Tão; et al. "MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy". Human Molecular Genetics (2019): https://doi.org/10.1093/hmg/ddz099.
    10.1093/hmg/ddz099
  11. Pinto, Sara M. A.; Calvete, Mário J. F.; Ghica, Mariana E.; Soler, Sérgio; Gallardo, Iluminada; Pallier, Agnès; Laranjo, Mariana B.; et al. "A biocompatible redox MRI probe based on a Mn(ii)/Mn(iii) porphyrin". Dalton Transactions 48 10 (2019): 3249-3262. http://dx.doi.org/10.1039/c8dt04775h.
    10.1039/c8dt04775h
  12. Morais, Catarina M.; Cardoso, Ana M.; Cunha, Pedro P.; Aguiar, Luísa; Vale, Nuno; Lage, Emílio; Pinheiro, Marina; et al. "Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions". Biochimica et Biophysica Acta (BBA) - Biomembranes 1860 12 (2018): 2619-2634. http://dx.doi.org/10.1016/j.bbamem.2018.10.002.
    10.1016/j.bbamem.2018.10.002
  13. Viegas, A.T.B.; Guedes, J.R.; Oliveira, A.R.; Cardoso, A.M.S.; Cardoso, A.L.C.. "miRNAs: New biomarkers and therapeutic targets in dementia". Current Pharmaceutical Design 23 5 (2017): 669-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017530528&partnerID=MN8TOARS.
    10.2174/1381612823666170111094702
  14. Cunha, P.P.; Costa, P.M.; Morais, C.M.; Lopes, I.R.; Cardoso, A.M.; Cardoso, A.L.; Mano, M.; Jurado, A.S.; Pedroso De Lima, M.C.P.. "High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors". Human Molecular Genetics 26 22 (2017): 4375-4387. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034256071&partnerID=MN8TOARS.
    10.1093/hmg/ddx323
  15. Cruz, R.Q.; Morais, C.M.; Cardoso, A.M.; Silva, S.G.; Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes". European Journal of Pharmaceutics and Biopharmaceutics 104 (2016): 7-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964330230&partnerID=MN8TOARS.
    10.1016/j.ejpb.2016.04.014
  16. Pinto, S.M.A.; Tomé, V.A.; Calvete, M.J.F.; Pereira, M.M.; Burrows, H.D.; Cardoso, A.M.S.; Pallier, A.; et al. "The quest for biocompatible phthalocyanines for molecular imaging: Photophysics, relaxometry and cytotoxicity studies". Journal of Inorganic Biochemistry 154 (2016): 50-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946887800&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2015.10.013
  17. Guedes, J.R.; Santana, I.; Cunha, C.; Duro, D.; Almeida, M.R.; Cardoso, A.M.; de Lima, M.C.P.; Cardoso, A.L.. "MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease". Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 3 (2016): 7-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956620147&partnerID=MN8TOARS.
    10.1016/j.dadm.2015.11.004
  18. Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; De Lima, M.C.P.; Jurado, A.S.. "New serine-derived gemini surfactants as gene delivery systems". European Journal of Pharmaceutics and Biopharmaceutics 89 (2015): 347-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920830778&partnerID=MN8TOARS.
    10.1016/j.ejpb.2014.12.013
  19. Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression". Molecular Pharmaceutics 12 3 (2015): 716-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924023696&partnerID=MN8TOARS.
    10.1021/mp5005349
  20. Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.; Cruz, R.; Zhu, K.; Pedroso De Lima, M.C.; Jurado, A.S.; Nyström, B.. "Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery". Molecular Pharmaceutics 11 3 (2014): 819-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901742907&partnerID=MN8TOARS.
    10.1021/mp400510a
  21. Kjøniksen, A.-L.; Calejo, M.T.; Zhu, K.; Cardoso, A.M.S.; De Lima, M.C.P.; Jurado, A.S.; Nyström, B.; Sande, S.A.. "Sustained release of naltrexone from Poly(N-Isopropylacrylamide) microgels". Journal of Pharmaceutical Sciences 103 1 (2014): 227-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890551451&partnerID=MN8TOARS.
    10.1002/jps.23780
  22. Cardoso, A.M.; Morais, C.M.; Silva, S.G.; Marques, E.F.; De Lima, M.C.P.; Jurado, M.A.S.. "Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane interactions". International Journal of Pharmaceutics 474 1-2 (2014): 57-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906267891&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2014.08.011
  23. Calejo, M.T.; Cardoso, A.M.S.; Kjøniksen, A.-L.; Zhu, K.; Morais, C.M.; Sande, S.A.; Cardoso, A.L.; et al. "Temperature-responsive cationic block copolymers as nanocarriers for gene delivery". International Journal of Pharmaceutics 448 1 (2013): 105-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875930565&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2013.03.028
  24. Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de Lima, M.C.. "Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications". Current Pharmaceutical Design 19 16 (2013): 2895-2923. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878655380&partnerID=MN8TOARS.
    10.2174/1381612811319160006
  25. Calejo, M.T.; Cardoso, A.M.S.; Marques, E.F.; Araújo, M.J.; Kjøniksen, A.-L.; Sande, S.A.; de Lima, M.C.P.; Jurado, A.S.; Nyström, B.. "In vitro cytotoxicity of a thermoresponsive gel system combining ethyl(hydroxyethyl) cellulose and lysine-based surfactants". Colloids and Surfaces B: Biointerfaces 102 (2013): 682-686. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867835593&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2012.09.033
  26. Silva, S.G.; Alves, C.; Cardoso, A.M.S.; Jurado, A.S.; Pedroso De Lima, M.C.; Vale, M.L.C.; Marques, E.F.. "Synthesis of gemini surfactants and evaluation of their interfacial and cytotoxic properties: Exploring the multifunctionality of serine as headgroup". European Journal of Organic Chemistry 9 (2013): 1758-1769. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875008251&partnerID=MN8TOARS.
    10.1002/ejoc.201201396
  27. Cardoso, A.M.; Trabulo, S.; Cardoso, A.L.; Maia, S.; Gomes, P.; Jurado, A.S.; Pedroso De Lima, M.C.. "Comparison of the efficiency of complexes based on S413-PV cell-penetrating peptides in plasmid DNA and siRNA delivery". Molecular Pharmaceutics 10 7 (2013): 2653-2666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879735661&partnerID=MN8TOARS.
    10.1021/mp400078h
  28. Cardoso, A.M.S.; Trabulo, S.; Cardoso, A.L.; Lorents, A.; Morais, C.M.; Gomes, P.; Nunes, C.; et al. "S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization". Biochimica et Biophysica Acta - Biomembranes 1818 3 (2012): 877-888. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856059612&partnerID=MN8TOARS.
    10.1016/j.bbamem.2011.12.022
  29. Calejo, M.T.; Kjoniksen, A.-L.; Pinazo, A.; Pérez, L.; Cardoso, A.M.S.; Pedroso De Lima, M.C.; Jurado, A.S.; Sande, S.A.; Nyström, B.. "Thermoresponsive hydrogels with low toxicity from mixtures of ethyl(hydroxyethyl) cellulose and arginine-based surfactants". International Journal of Pharmaceutics 436 1-2 (2012): 454-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865288628&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2012.07.018
  30. Cardoso, A.M.S.; Faneca, H.; Almeida, J.A.S.; Pais, A.A.C.C.; Marques, E.F.; De Lima, M.C.P.; Jurado, A.S.. "Gemini surfactant dimethylene-1,2-bis(tetradecyldimethylammonium bromide)-based gene vectors: A biophysical approach to transfection efficiency". Biochimica et Biophysica Acta - Biomembranes 1808 1 (2011): 341-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649777308&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.09.026
  31. Trabulo, S.; Cardoso, A.M.; Santos-Ferreira, T.; Cardoso, A.L.; Simões, S.; Pedroso De Lima, M.C.. "Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents". Molecular Pharmaceutics 8 4 (2011): 1120-1131. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961082146&partnerID=MN8TOARS.
    10.1021/mp100426e
Capítulo de livro
  1. Cardoso, Ana M.; Cardoso, Ana L; Pedroso de Lima, Maria C; Jurado, Amália S. "Non-viral therapeutic approaches for modulation of gene expression: nanotechnological strategies to overcome biological challenges". In Nanoparticles in the Life Sciences and Biomedicine, 409-432. Pan Stanford Publishing, 2018.
  2. Cardoso, Ana. "Gene delivery mediated by gemini surfactants: structure-activity relationships". In Engineering of Nanobiomaterials, 227-256. Elsevier, 2016.
    Publicado • 10.1016/B978-0-323-41532-3.00007-5
  3. Cardoso, Ana. "Recent trends in nanotechnology towards CNS diseases: Lipid-based nanoparticles and exosomes for targeted therapeutic delivery". 2016.
    10.1016/bs.irn.2016.05.002
  4. Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Düzgünes, N.; Jurado, A.S.; De Lima, M.C.P.. "Cell-penetrating peptide-based systems for nucleic acid delivery: A biological and biophysical approach". In Methods in Enzymology, 277-300. 2012.
    10.1016/B978-0-12-391858-1.00014-9
Poster em conferência
  1. Guedes, Joana; Ferreira, Pedro; Laranjo, Mariana; Reis, Tiago; Cardoso, A.M.; et al. "Abnormal microgia-mediated prunning in the cerebellum induces circuitry and behavioral disfunction in mice". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  2. Morais, Catarina; Cardoso, A.M.; at al.. "Silencing of key-enzymes of lipid metabolism combined with multitargeted receptor tyrosine kinase inhibitors as a new therapeutic strategy for glioblastoma". Trabalho apresentado em FEBS 2019 Advanced Course: Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019.
  3. Cardoso, A.M.; Sousa, Madalena G.; Morais, Catarina. "Combined therapeutic approach to tackle glioblastoma: modulation of miRNAs involved in bioenergetic metabolism for cell sensitization to chemotherapy". Trabalho apresentado em MitoPorto – Advances in Mitochondrial Research, 2017.
  4. Morais, Catarina; Cunha, Pedro; Cardoso, A.M.; et al. "Membrane perturbations induced by acylated S4(13)-PV analogs: relevance to nucleic acid delivery". Trabalho apresentado em 34th European Peptide Symposium, 2016.
  5. Cunha, Pedro; Costa, Raquel; Costa, Pedro; Cardoso, A.M.; et al. "A promising targeted strategy to overcome drug-resistance in glioblastoma". Trabalho apresentado em EMBO workshop: Modern DNA concepts and tools for safe gene transfer and modification, 2015.
  6. Cunha, Pedro; Costa, Pedro; Costa, Raquel; Custódia, Carlos; Branco, Ruben; Morais, Catarina; Cardoso, A.M.; et al. "MicroRNA modulation renders glioblastoma cells sensitive to chemotherapy". Trabalho apresentado em 49th Annual Scientific Meeting of the European Society for Clinical Investigation, 2015.
  7. Cruz, Rita; Morais, Catarina; Cardoso, A.M.; et al. "Gene silencing mediated by gemini-based formulations". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014.
  8. Guedes, Joana; Santana, Isabel; Cunha, Catarina; Almeida, Rosário; Cardoso, A.M.; et al. "Molecular and phenotypic alterations in the mononuclear phagocyte system from Alzheimer’s disease patients". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014.
  9. Cunha, Pedro; Costa, Pedro; Costa, Raquel; Branco, Ruben; Morais, Catarina; Cardoso, A.M.; et al. "MicroRNA-21 and micro RNA-128 modulation sensitizes glioblastoma cells to sunitinib treatement". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014.
  10. Calvete, Mario; Pinto, Sara; Cardoso, A.M.; et al. "A biocompatible manganese (III) phthalocyanine for development of MRI contrast agents". Trabalho apresentado em COST Action TD1004, 2014.
  11. Morais, Catarina; Cardoso, A.M.; et al. "Nuclear and mitochondrial gene transfection mediated by cationic pentacyclic triterpenoid derivatives". Trabalho apresentado em GEM/GERLI Lipidomics Meeting: From Membranes to Pathologies, 2013.
  12. Cardoso, A.M.; et al. "The structural architecture of Bis-quat gemini surfactants is crucial for their DNA delivery ability". Trabalho apresentado em 9th EBSA – European Biophysics Congress, 2013.
  13. Silva, Sandra; Alves, Claudia; Cardoso, A.M.; et al. "Rational design of cleavable cationic gemini surfactants: exploring the multifunctionality of serine as headgroup". Trabalho apresentado em RICI5 – 5th Iberian Meeting on Colloids and Interfaces, 2013.
  14. Cardoso, A.M.; et al. "Gemini Surfactant-Based Gene Delivery Systems: Transfection Efficiency And Cytotoxicity Depend On Hydrocarbon Chain Length And Helper Lipids". Trabalho apresentado em III Congress of the Portuguese Society of Pharmaceutical Sciences/IX Spanish-Portuguese Conference on Controlled Drug Delivery - New Trends in Pharmacological Sciences, 2011.
  15. Cardoso, A.M.; Morais, Catarina; et al. "Transfection efficiency of Gemini surfactant-based gene delivery systems as affected by helper lipids". Trabalho apresentado em RICI4 - 4th Iberian Meeting on Colloids and Interfaces, 2011.
  16. Cardoso, A.M.; et al. "A biophysical study on the interaction of S4(13)-PV cell penetrating peptide with model lipid membranes". Trabalho apresentado em Meeting of Peptide Vectors and Delivery of Therapeutics, 2011.
  17. Cardoso, A.M.; et al. "A biophysical study on the interaction of S413-PV cell penetrating peptide with model lipid membranes". Trabalho apresentado em XVII Congresso Nacional de Bioquímica, 2010.
  18. Trabulo, Sara; Cardoso, A.M.; et al. "Silencing of survivin enhances the sensitivity of cancer cells to chemotherapeutic agents". Trabalho apresentado em 21st Meeting of the European Association for Cancer Research, 2010.
  19. Cardoso, A.M.; et al. "Biophysical properties and transfection ability of ethanediyl-alfa,omega-bis(-N-tetradecyl,N,N’,dimethylammonium bromide)-based vectors". Trabalho apresentado em International Courses on Toxicology, 2010.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021 Multiparametric MRI characterization of the G144 GBM model 38th Annual Scientific Meeting of the European Society for Magnetic resonance in Medicine and Biology (ESMRMB)
(Barcelona, Espanha)
2019 Long Non-Protein Coding RNA MVIH Silencing as a Therapeutic Approach for Glioblastoma 3rd International Symposium on Frontiers in Molecular Science - RNA Regulatory Networks
(Lisboa, Portugal)
2019 Silencing of key-enzymes of lipid metabolism combined with multitargeted receptor tyrosine kinase inhibitors as a new therapeutic strategy for glioblastoma II FEBS Advanced Lecture Course on Oncometabolism-From Conceptual Knowledge to Clinical Applications
(Luso, Portugal)
2019 Upgrading S413-PV peptide to mediate gene silencing in cancer cells through peptide lauroylation and histidine-enrichment III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
(Covilhã, Portugal)
2018 Gold Nanoparticles as Multimodal Imaging Agents XIX Brazilian Meeting on Inorganic Chemistry, VI Latin American Meeting on Biological Inorganic Chemistry, VIII Brazilian Meeting on Rare Earths
(Fortaleza, Brasil)
2017 Membrane lipids: protein partners for good and for evil. A case study in glioblastoma 6th Workshop in Lipidomics
(Aveiro, Portugal)
2016 Interaction of acylated S413-PV analogs with lipid membranes 15th Iberian Peptide Meeting
(Porto, Portugal)
2014 The interaction of gene delivery systems with membranes as a modulator of transfection efficiency 3rd Workshop in Lipidomics
(Aveiro, Portugal)
2014 Improving the ability of S4(13)PV cell-penetrating peptide to mediate siRNA delivery through peptide acylation SFNano In vitro/in vivo correlation workshop – Relevant tools and models for the translation of advanced drug delivery systems
(Porto, Portugal)
2014 Gemini surfactants as gene delivery systems: disclosing the properties leading to transfection activity 20th International Symposium on Surfactants in Solution
(Coimbra, Portugal)
2013 Gene Transfer Mediated by Bis-Quaternary Gemini Surfactants Depends on Complex Architecture RICI5 – 5th Iberian Meeting on Colloids and Interfaces
(San Sebastian, Espanha)
2013 Efficient siRNA delivery mediated by S4(13)-PV cell penetrating peptide-based systems: a comparative study 13th Naples Workshop on Bioactive Peptides – Conformation and Activity in Peptides: Relationships and Interactions
(Nápoles, Itália)
2012 Towards a biocompatible thermo-responsive hydrogel for pharmaceutical applications – The combined system of ethyl(hydroxyethyl) cellulose and lysine-based surfactants CRS Nordic Chapter - Drug Delivery and Targeting
(Reykjavik, Islândia)
2011 Membrane lipid interactions with cell-penetrating peptides: lessons on the role of lipids in membrane functioning RICI4 - 4th Iberian Meeting on Colloids and Interfaces
(Porto, Portugal)
2011 Membrane lipid interactions with cell-penetrating peptides: lessons on the role of lipids in membrane functioning RICI4 - 4th Iberian Meeting on Colloids and Interfaces
(Porto, Portugal)
2011 Transfection efficiency of Gemini surfactant-based gene delivery systems as affected by nature of formulation and method of preparation XXXVI Jornadas Portuguesas de Genética
(Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2015/09/01 - 2016/09/10 MiRNA-based metabolic modulation in glioblastoma cells: a strategy to surpass tumor chemoresistance
Orientador
CNC.IBILI, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2017/10 - 2017/11 Nature Masterclasses Online Course: Focus on Peer Review
Outro
Focus on Peer Review
Springer Nature, Luxemburgo
2017/01 - 2017/02 Coursera Online Course: Design and Interpretation of Clinical Trials
Outro
Design and Interpretation of Clinical Trials
Johns Hopkins University Center for Global Health, Estados Unidos
2016/10 - 2016/11 Coursera Online Course: Basics of Extracellular Vesicles
Outro
Basics of Extracellular Vesicles
University of California Irvine Cancer Research Institute, Estados Unidos
2016/03 - 2016/05 Coursera Online Course: Epigenetic Control of Gene Expression
Outro
Epigenetic Control of Gene Expression
The University of Melbourne, Austrália
2015/06 - 2015/06 Course: MiRNAs and non-coding RNAs in cell biology and human disease
Outro
MiRNAs and non-coding RNAs in cell biology and human disease
Instituto de Medicina Molecular, Portugal
2013/09 - 2013/09 Course in Laboratorial Animal Science, category C of FELASA
Outro
Course in Laboratorial Animal Science
Universidade de Coimbra, Portugal
2012/06 - 2012/06 Course of Science Communication for Researchers
Outro
Course of Science Communication for Researchers
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2016/07/07 Avaliação do efeito da mutação c.900-901dupGT do gene GRN na resposta imune e autofagia: um estudo em portadores heterozigóticos e homozigóticos
Arguente principal
Catarina Isabel Carvalhas de Almeida (Outro)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021 - 2021 Electrophysiology of plasma membranes: Patch clamp VIII CELL CULTURE AND TISSUE TRAINING COURSE (Outros) Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2019 LabTalks Exploring the role of circulating miRNAs in Delirium and Dementia (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018 - 2019 LabTalks Targeted gene/drug therapies for brain tumors: from the immune microenvironment to the stem cell niche (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016 - 2019 Lnc-RNAs for cancer therapy Advanced Therapies (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2014 Lipidómica Funcional MSc in Biochemistry (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011 - 2014 Toxicologia Bioquímica e Biofísica Bioquímica (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011 - 2012 Biomembranas MSc in Biochemistry (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Tutoria

Tópico Nome do aluno
2019 - 2021 Extracellular vesicles and their role in the tumor microenvironment of glioblastoma multiforme Guilherme Faria
2019 - 2020 Isolation and characterization of extracellular vesicles produced from glioblastoma cells and assessment of the impact of temozolomide in glioblastoma spheroid invasion Inês Oliveira
2019 - 2020 Modelos celulares in vitro para o estudo de terapias para glioblastoma: Vantagens e desvantagens Susana Gomes
2018 - 2019 Isolamento e caracterização de exossomas de células de glioblastoma Francisco Tiago
2018 - 2019 Validação de um protocolo de fracionamento celular para quantificação de proteína em diferentes compartimentos celulares Inês Oliveira
2014 - 2015 Modulação dos níveis de miRNAs envolvidos em alterações metabólicas em linhas celulares de glioblastoma (U87 e DBTRG) como abordagem terapêutica Catarina Luz
2014 - 2015 Estratégia terapêutica para glioblastoma baseada no silenciamento de um gene do metabolismo lipídico combinado com a utilização de um fármaco quimioterapêutico Márcia Teixeira
2012 - 2013 Surfactantes Gemini Catiónicos no Transporte de Material Genético: Abordagem Biológica e Biofísica Ana Rita Cruz
Distinções

Outra distinção

2015 Bolsa Individual de Pos-Doutoramento
Fundação para a Ciência e a Tecnologia, Portugal
2010 Bolsa Individual de Doutoramento
Fundação para a Ciência e a Tecnologia, Portugal