I am a Chemist with a PhD in Computational Chemistry (2003) by the Fac. of Sciences Univ. of Porto supervised by Prof. Ferreira Gomes. In 2004 I was a postdoc in Sweden supervised by Prof. Leif Eriksson and in 2005-6 in Germany, supervised by Prof. Florian Müller-Plathe. In 2007 I returned to Portugal to work as a postdoc at the Faculty of Pharmacy of the Univ. of Lisbon in Prof. Rui Moreira lab. In 2008 I was hired as a FCT researcher (Ciência2007 research program) in the same lab and thereafter at REQUIMTE/ Faculty of Sciences, University of Porto (Ciência2008 and REQUIMTE research programs). Presently I am an Assistant Researcher at CBIOS/Universidade Lusófona de Humanidades e Tecnologia (Lisbon) where I develop an independent research line (soft matter, with medicinal chemistry applications particularly in multidrug resistance). My main scientific contributions are in the field of Multidrug resistance particularly regarding the study of ABC transporters with an ongoing financed FCT project as Co-PI. However, I also develop research on other subject matter through FCT financed ongoing projects as leader of the computational team (one) or Co-PI (two): i) Studying the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7) to rescue F508del-CFTR and other mutants ii) Developing novel strategies to find new therapeutic approaches to the most common mitochondrial fatty acid beta-oxidation disorder (mFAOD), iii) Developing selective pharmacological modulators for Protein Kinase C (PKC) isozymes and use computational approaches to find novel p53-MDM2 interaction inhibitors also for fighting cancer. I participated in 10 projects (4 still ongoing) either as Co-PI (3), leader of the computational team (3), consultant (1) or member of the computational team. I published 57 articles in top peer-reviewed journals, 3 book sections and participated in the organization of 2 national conferences. Most papers were published in Q1 journals mainly in Computational Chemistry, Medicinal Chemistry, and Biochemistry with 7 papers published in journals with IF > 5. My work was presented through 108 posters and 47 oral communications (14 invited). I supervised 4 PhD theses (2 ongoing), 3 MSc theses dissertations, 6 post-docs and 7 scientific initiations. I was a member in 7 academic juries of PhD and master vivas (4 as the main arguer). Presently I am a Vice-President of the Computational Chemistry group of the Portuguese Chemical Society To keep up with the developments the reader is advised to check my professional website http://chemistrybits.com where I publish relevant news about project outputs, conferences, and any other information regarding my research.

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Daniel José Viegas Antunes dos Santos dos Santos

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