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Ana E Sousa is Investigator Coordinator and Full Professor at the Faculdade de Medicina da Universidade de Lisboa, where she leads the Clinical Immunology Laboratory since 2014, and Group Leader at the Instituto de Medicina Molecular João Lobo Antunes (iMM) since 2003. After completing her formal training as an Internist and a subsequent PhD in the field of HIV/AIDS immunopathogenesis, she has pursued a career as full-time researcher, leading a group dedicated to human immunodeficiencies at the iMM, a reference Institute for science in Portugal. The main research topic is human T cell development and homeostasis. Her research group gathers clinical and basic investigators in such a way to guarantee the scientific training of MD, biomedical and computational researchers with the ultimate goal of identifying new strategies for immunological reconstitution. Between 2009 and 2012, she served as President of Portuguese Society for Immunology. Among her scientific contributions to the HIV/AIDS field, it is worth emphasizing a couple of key papers that helped establish hyper-immune activation as a main determinant of HIV disease progression (Sousa, JI2002; Grossman, NatureMed2002), and that her work represents an international reference source for the study of HIV-2 infection, a naturally-occurring model of attenuated HIV disease. Additionally, her lab integrates a reference centre that performs diagnosis, specialized follow-up and research in primary immunodeficiencies, rare diseases considered natural experiments from which we can learn a great deal about the human immune system. The ultimate goal is that her research on T-cell development in the human thymus and lymphoid tissue preservation, particularly in the context of persistent immune activation, translates into innovative immune-based therapies.
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Identificação

Identificação pessoal

Nome completo
Ana Espada de Sousa

Nomes de citação

  • Sousa, Ana E
  • Ana E Sousa
  • Ana Espada de Sousa

Identificadores de autor

Ciência ID
D015-D3A2-992D
ORCID iD
0000-0002-4618-9799

Endereços de correio eletrónico

  • asousa@medicina.ulisboa.pt (Profissional)
  • anaespadadesousa@gmail.com (Pessoal)

Telefones

Fax
  • 217999527 (Profissional)
Telefone
  • 217999525 (Profissional)
Telemóvel
  • 938335104 (Pessoal)

Moradas

  • Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa. Av Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Medicina Clínica
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Clínica - Alergologia
  • Ciências Médicas e da Saúde - Medicina Clínica - Medicina Geral e Medicina Interna
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1)
Formação
Grau Classificação
2012/10/10
Concluído
 Agregation (Título de Agregado)
Universidade de Lisboa Faculdade de Medicina, Portugal
"N/A" (TESE/DISSERTAÇÃO)
 N/A
2000/11/20
Concluído
 PhD (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"DOIS MODELOS CLÍNICOS DE INVESTIGAÇÃO DA IMUNOPATOGÉNESE DA SIDA: A RECONSTITUIÇÃO IMUNOLÓGICA APÓS TERAPÊUTICA ANTIRETROVIRAL E A INFECÇÃO PELO HIV2 " (TESE/DISSERTAÇÃO)
 20/20
1989 - 1994
Concluído
 Medicina Interna (Título de especialista)
Hospital de Santa Maria, Portugal
 19,8/20
1986
Concluído
 MD (Licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
"N/A" (TESE/DISSERTAÇÃO)
 17,1/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/01/11 - Atual Investigador Coordenador (carreira) (Investigação) Faculdade de Medicina da Universidade de Lisboa, Portugal
Faculdade de Medicina da Universidade de Lisboa, Portugal
(...)
2013/09/01 - 2017/01/10 Investigador principal (carreira) (Investigação) Faculdade de Medicina da Universidade de Lisboa, Portugal
2007/09/01 - 2013/08/31 Investigador Auxiliar (carreira) (Investigação) Faculdade de Medicina da Universidade de Lisboa, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/05/02 - Atual Professor Catedrático Convidado (Docente Universitário) Faculdade de Medicina da Universidade de Lisboa, Portugal
2013 - 2018/05/01 Professor Associado Convidado (Docente Universitário) Faculdade de Medicina da Universidade de Lisboa, Portugal
2005 - 2013 Professor Auxiliar Convidado (Docente Universitário) Faculdade de Medicina da Universidade de Lisboa, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2009/11/01 - 2012/11/26 Presidente Portuguese Society for Immunology, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2014/06/16 - Atual Director of the Clinical Immunology Laboratory Faculdade de Medicina da Universidade de Lisboa, Portugal
2007/11/21 - Atual Co-Coordinator of the Center for Primary Immunodeficiency Centro Académico de Medicina de Lisboa, Portugal
2003/01/01 - Atual Group Leader Instituto de Medicina Molecular, Portugal
2016/03/14 - 2022/09/01 Coordinator of the GAPIC (Department for the promotion of scientific investigation for medical students) Faculdade de Medicina da Universidade de Lisboa, Portugal
2009/06/01 - 2016/03/14 Member of the Directive Board of the GAPIC (Department for the promotion of scientific investigation for medical students) Faculdade de Medicina da Universidade de Lisboa, Portugal
2009/10/01 - 2013/05/14 Member of the Directive Board, Treasurer Sociedade de Ciências Médica de Lisboa, Portugal
2004/01/01 - 2006/09/01 Director of the Flow Cytometry Unit Instituto de Medicina Molecular, Portugal
2004/01/01 - 2005/12/31 Management Committee of the Egas Moniz Building (site of the Instituto de Medicina Molecular) Faculdade de Medicina da Universidade de Lisboa, Portugal
2000/10/01 - 2001/09/30 Specialist in Internal Medicine Hospital de Santa Maria, Portugal
1996/10/01 - 2001/09/30 Honorary Lecturer - Clinical Immunology Faculdade de Medicina da Universidade de Lisboa, Portugal
1996/01/01 - 2000/10/01 PhD Scholarship from Portuguese Science Foundation Fundação para a Ciência e a Tecnologia, Portugal
1992/10/01 - 1996/10/01 Honorary Lecturer - Medicine 2 Faculdade de Medicina da Universidade de Lisboa, Portugal
1986/01/01 - 1995/12/31 General internship / Residency / Specialist in Internal Medicine Hospital de Santa Maria, Portugal
Projetos

Bolsa

Designação Financiadores
2021/10/06 - 2025/10/05 Mye-InfoBank - Converting molecular profiles of myeloid cells into biomarkers for inflammation and cancer
CA20117
Investigador
Instituto de Medicina Molecular, Portugal
 European Union
Em curso
2021/03/29 - 2024/03/28 Targeting naïve CD4 T cells to avoid human immunodeficiency
PTDC/MED-IMU/0938/2020
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/10/01 - 2021/09/30 Exploring the role of microRNAs in T cell function and anti-HIV defense
PTDC/BIA-CEL/29257/2017
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/08/06 - 2021/08/05 Quantitative Studies of HIV Latency
PTDC/MAT-APL/31602/2017
Investigador
Universidade de Lisboa Faculdade de Medicina, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/01 - 2021/05/31 Investigation of a Human Virus Tumor Gene through a Chimera Virus Mouse Infection Model
PTDC/BIA-VIR/27947/2017
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/06/01 - 2021/05/31 Harnessing Follicular Helper T Cells to Control HIV
PTDC/MED-IMU/30474/2017
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/12/01 - 2021/01/31 Accelerating progress toward the new era of precision medicine (PAC-PRECISE)
PAC – PRECISE - LISBOA-01-0145-FEDER-016394
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/01/01 - 2020/12/31 An Omics Network to Prevent and Control Infectious Diseases and Antimicrobial Resistance (PAC-ONEIDA)
PAC - ONEIDA - LISBOA-01-0145-FEDER-016417
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/06/30 - 2020/12/30 COVID-19 prognosis: innate immune determinants
Projecto nº 803; FCT - RESEARCH4COVID 19
Investigador
Instituto de Medicina Molecular, Portugal
Em curso
2016/12 - 2020/11 Accelerating progress toward the new era of precision medicine (PAC-PRECISE)
PAC PRECISE - LISBOA-01-0145-FEDER-016394
 Fundação para a Ciência e a Tecnologia
2020/05/02 - 2020/07/31 COVID-19 pneumonia outcome: an immunological approach
125_596759906
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2015 - 2018 European Network linking informatics and genomics of helper T cells (ENLIGHT-TEN)
"Enlight-Ten" - MSCA-ITN-2015-ETN
"Enlight-Ten" - MSCA-ITN-2015-ETN
Investigador
Instituto de Medicina Molecular, Portugal
 European Commission
Concluído
2014 - 2018 European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells (Mye-EUNITER)
COST BM1404
Investigador
Instituto de Medicina Molecular, Portugal
 European Commission
Concluído
2015/01/01 - 2017/12/31 Targeting Germinal Centre Dysregulation in Allergy
HMSP-ICT/0034/2013
HMSP-ICT/0034/2013
Investigador
Instituto de Medicina Molecular, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2016 Platform for the Development of Young Physician-Scientists
2013FCG-IMM
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação Calouste Gulbenkian
Concluído
2013/06/01 - 2015/08/31 Bee Venom as a tool to expand the human regulatory T-cell compartment
PTDC/DTP-PIC/0508/2012
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2014/01/01 - 2014/12/31 Achieving gut integrity in HIV/AIDS through IL-22
EXPL/DTP-PIC/0854/2013
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2014 MODULATION OF HIV REPLICATION AND LATENCY IN HUMAN CD4 T CELLS BY REGULATORY SMALL RNAS
#39114
#39114
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Merck Sharp and Dohme Ltd
2010 - 2014 HIV/AIDS: contribute of naïve CD4 T cell homeostasis.
PTDC/SAU-MIC/109786/2009
PTDC/SAU-MIC/109786/2009
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2013/12/31 Cellular and molecular requirements in human Regulatory T cell development
PTDC/SAU-IMU/113541/2009
Investigador
Instituto de Medicina Molecular, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2012 Lymphoid tissues in HIV-2 infected patients
PIC/IC/82712/2007
PIC/IC/82712/2007
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2012 Long-term impact of thymectomy performed in early infancy
PIC/IC/83068/2007
PIC/IC/83068/2007
Investigador
Instituto de Medicina Molecular, Portugal

Hospital de Santa Cruz, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/11/01 - 2011/04/30 HIV-2 infection and thymus
PTDC/SAU-MII/66248/2006
PTDC/SAU-MII/66248/2006
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2011 Cellular and Molecular Response of HIV-2 and HIV-1 infection to integration modulation
IISP ID#35271
IISP ID#35271
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Merck Sharp and Dohme Ltd
Concluído
2008 - 2011 Immune Reconstitution after Unrelated and Haplotype-Mismatched Stem Cell Transplantation.
PTDC/SAU-MII/67662/2006
PTDC/SAU-MII/67662/2006
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2011 Programa VIH-SIDA IMM-FCG
2007FCG-IMM
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação Calouste Gulbenkian
Concluído
2005 - 2008 The role of IL- 7 in the regulation of CD4+ T cell populations in humans
POCI/BIA-BCM/61079-2004
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2005/06/01 - 2007/12/31 T cell production in HIV immunodeficiency
POCI/SAU-MMO/60333/2004
POCI/SAU-MMO/60333/2004
Investigador responsável
Instituto de Medicina Molecular, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/06/01 - 2007/06/30 The role of IL-7 in the homeostatic regulation of CD4+ T lymphocyte populations in humans
POCI/BIA-BCM/61079/2004
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2005 - 2007 HIV-2 specific T cells
POCI/SAU-IMI/55368/2004
POCI/SAU-IMI/55368/2004
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2001 - 2004 HIV-2 infection as a model for the investigation of AIDS pathogenesis.
POCTI 36312/CBO2000
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Torres-Valle, Alba; Aragon, Larraitz; Silva, Susana L.; Serrano, Cristina; Marcos, Miguel; Melero, Josefa; Bonroy, Carolien; et al. "In-depth blood immune profiling of Good syndrome patients". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1285088.
    10.3389/fimmu.2023.1285088
  2. Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; et al. "Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity". Cellular & Molecular Immunology (2023): http://dx.doi.org/10.1038/s41423-023-01052-7.
    10.1038/s41423-023-01052-7
  3. Gomes, André M. C.; Farias, Guilherme B.; Trombetta, Amelia C.; Godinho-Santos, Ana; Parreira, Inês; Gonçalves, Hélder Diogo; Simões, Mariana Lessa; et al. "Phenotype of BTK-lacking myeloid cells during prolonged COVID-19 and upon convalescent plasma". European Journal of Haematology 110 2 (2023): 209-212. http://dx.doi.org/10.1111/ejh.13881.
    Publicado • 10.1111/ejh.13881
  4. Cláudia Varandas; Maria Conceição Pereira-Santos; Marta Neto; Ana E. Sousa; Anabela Lopes; Susana L. Silva. "Serum IL-22 binding protein as a marker for atopic dermatitis activity and response to dupilumab treatment". Clinical & Experimental Allergy 52 6 (2022): 820-823. https://doi.org/10.1111/cea.14147.
    10.1111/cea.14147
  5. Motta-Raymundo, Adriana; Rosmaninho, Pedro; Santos, Diana F.; Ferreira, Ruben D.; Silva, Sara P.; Ferreira, Cristina; Sousa, Ana E.; Silva, Susana L.. "Contribution of Helicobacter pylori to the Inflammatory Complications of Common Variable Immunodeficiency". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.834137.
    10.3389/fimmu.2022.834137
  6. Nunes-Cabaço, Helena; Ramalho-dos-Santos, Andreia; Pires, Ana R.; Martins, Leila R.; Barata, João T.; Sousa, Ana E.. "Human CD4 T Cells From Thymus and Cord Blood Are Convertible Into CD8 T Cells by IL-4". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.834033.
    10.3389/fimmu.2022.834033
  7. Passos, Vânia; Pires, Ana R.; Foxall, Russell B.; Nunes-Cabaço, Helena; Sousa, Ana E.. "Expression of Human Endogenous Retroviruses in the Human Thymus Along T Cell Development". Frontiers in Virology 2 (2022): http://dx.doi.org/10.3389/fviro.2022.826393.
    10.3389/fviro.2022.826393
  8. Guilherme B. Farias; Robert Badura; Carolina M Conceição; André Gomes; Ana Godinho-Santos; Joel Laia; Pedro Rosmaninho; et al. "Acute HIV-1 and SARS-CoV-2 Infections Share Slan+ Monocyte Depletion—Evidence from an Hyperacute HIV-1 Case Report". Viruses (2021): https://www.mdpi.com/1999-4915/13/9/1805.
    10.3390/v13091805
  9. Aguiar de Sousa, Diana; Pereira-Santos, Maria Conceição; Serra-Caetano, Ana; Neto, Lia Lucas; Sousa, Ana Luísa; Gabriel, Denis; Correia, Manuel; et al. "Matrix Metalloproteinase-9 Levels are Associated with Brain Lesion and Persistent Venous Occlusion in Patients with Cerebral Venous Thrombosis". Thrombosis and Haemostasis 121 11 (2021): 1476-1482. http://dx.doi.org/10.1055/s-0041-1726094.
    10.1055/s-0041-1726094
  10. del Pino-Molina, Lucía; López-Granados, Eduardo; Lecrevisse, Quentin; Torres Canizales, Juan; Pérez-Andrés, Martín; Blanco, Elena; Wentink, Marjolein; et al. "Dissection of the Pre-Germinal Center B-Cell Maturation Pathway in Common Variable Immunodeficiency Based on Standardized Flow Cytometric EuroFlow Tools". Frontiers in Immunology 11 (2021): http://dx.doi.org/10.3389/fimmu.2020.603972.
    10.3389/fimmu.2020.603972
  11. Ferreira JA; Neves M; Alpalhão M; Pereira P; Cunha D; Ferreira F; Santus R; Sousa AE; Filipe PL. "EDU (5-Ethynyl-2'-Deoxyuridine)-Coupled Fluorescence-Intensity Analysis: Determining Absolute Parameters of the Cell Cycle.". Methods in molecular biology (Clifton, N.J.) (2021): http://europepmc.org/abstract/med/34085222.
    10.1007/978-1-0716-1538-6_12
  12. Giardino, G.; Sharapova, S.O.; Ciznar, P.; Dhalla, F.; Maragliano, L.; Radha Rama Devi, A.; Islamoglu, C.; et al. "Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations". Journal of Clinical Immunology (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85100001252&partnerID=MN8TOARS.
    10.1007/s10875-021-00967-y
  13. Aguiar de Sousa, D.; Pereira-Santos, M.C.; Serra-Caetano, A.; Lucas Neto, L.; Sousa, A.L.; Gabriel, D.; Correia, M.; et al. "Blood biomarkers associated with inflammation predict poor prognosis in cerebral venous thrombosis:: a multicenter prospective observational study". European Journal of Neurology 28 1 (2021): 202-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092163063&partnerID=MN8TOARS.
    10.1111/ene.14526
  14. Lhermitte, Ludovic; Barreau, Sylvain; Morf, Daniela; Fernandez, Paula; Grigore, Georgiana; Barrena, Susana; de Bie, Maaike; et al. "Automated identification of leukocyte subsets improves standardization of database-guided expert-supervised diagnostic orientation in acute leukemia: a EuroFlow study". Modern Pathology 34 1 (2020): 59-69. http://dx.doi.org/10.1038/s41379-020-00677-7.
    10.1038/s41379-020-00677-7
  15. Cassetta, Luca; Bruderek, Kirsten; Skrzeczynska-Moncznik, Joanna; Osiecka, Oktawia; Hu, Xiaoying; Rundgren, Ida Marie; Lin, Ang; et al. "Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation". Journal for ImmunoTherapy of Cancer 8 2 (2020): e001223. http://dx.doi.org/10.1136/jitc-2020-001223.
    10.1136/jitc-2020-001223
  16. Gullo, Irene; Costa, Catarina; Silva, Susana L; Ferreira, Cristina; Motta, Adriana; Silva, Sara P; Ferreira, Rúben Duarte; et al. "The Dysfunctional Immune System in Common Variable Immunodeficiency Increases the Susceptibility to Gastric Cancer". Cells 9 6 (2020): 1498. http://dx.doi.org/10.3390/cells9061498.
    10.3390/cells9061498
  17. Grossman, Zvi; Singh, Nevil J.; Simonetti, Francesco R.; Lederman, Michael M.; Douek, Daniel C.; Deeks, Steven G.; And 8 contibuting authors with full authorship. "‘Rinse and Replace’: Boosting T Cell Turnover To Reduce HIV-1 Reservoirs". Trends in Immunology (2020): http://dx.doi.org/10.1016/j.it.2020.04.003.
    10.1016/j.it.2020.04.003
  18. Godinho-Santos, A.; Foxall, R.B.; Antão, A.V.; Tavares, B.; Ferreira, T.; Serra-Caetano, A.; Matoso, P.; Sousa, A.E.. "Follicular Helper T Cells Are Major Human Immunodeficiency Virus-2 Reservoirs and Support Productive Infection". The Journal of infectious diseases 221 1 (2020): 122-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076502884&partnerID=MN8TOARS.
    10.1093/infdis/jiz431
  19. Badura, R.; Foxall, R.B.; Ligeiro, D.; Rocha, M.; Godinho-Santos, A.; Trombetta, A.C.; Sousa, A.E.. "Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment". Frontiers in Cellular and Infection Microbiology 10 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088815505&partnerID=MN8TOARS.
    10.3389/fcimb.2020.00347
  20. M. C. P. Santos; A. Serra-Caetano; E. Pedro; A. Melo; I. Caramalho; M. P. Barbosa; R. M. M. Victorino; A. E. Sousa. "Expansion of FOXP3+ regulatory CD4 T cells upon exposure to hymenoptera venom during the beekeeping season". Allergy (2019): https://doi.org/10.1111/all.13713.
    10.1111/all.13713
  21. Ana E Sousa. "EuroFlow-Based Flowcytometric Diagnostic Screening and Classification of Primary Immunodeficiencies of the Lymphoid System". Frontiers in Immunology (2019): http://dx.doi.org/10.3389/fimmu.2019.01271.
    10.3389/fimmu.2019.01271
  22. van der Burg M; Kalina T; Perez-Andres M; Vlkova M; Lopez-Granados E; Blanco E; Bonroy C; et al. "The EuroFlow PID Orientation Tube for Flow Cytometric Diagnostic Screening of Primary Immunodeficiencies of the Lymphoid System.". Frontiers in immunology (2019): http://europepmc.org/abstract/med/30886612.
    10.3389/fimmu.2019.00246
  23. Blanco, E.; Pérez-Andrés, M.; Arriba-Méndez, S.; Serrano, C.; Criado, I.; Del Pino-Molina, L.; Silva, S.; et al. "Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies". Journal of Allergy and Clinical Immunology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85063670071&partnerID=MN8TOARS.
    10.1016/j.jaci.2019.02.017
  24. Silva, S.L.; Fonseca, M.; Pereira, M.L.M.; Silva, S.P.; Barbosa, R.R.; Serra-Caetano, A.; Blanco, E.; et al. "Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden". Frontiers in Immunology 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076341519&partnerID=MN8TOARS.
    10.3389/fimmu.2019.02503
  25. Dorhoi A; Glaría E; Garcia-Tellez T; Nieuwenhuizen NE; Zelinskyy G; Favier B; Singh A; et al. "MDSCs in infectious diseases: regulation, roles, and readjustment.". Cancer immunology, immunotherapy : CII (2018): http://europepmc.org/abstract/med/30569204.
    10.1007/s00262-018-2277-y
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  87. Sousa, A.E.; Chaves, A.F.; Loureiro, A.; Victorino, R.M.M.. "Comparison of the frequency of interleukin (IL)-2-, interferon-¿-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes". Journal of Infectious Diseases 184 5 (2001): 552-559. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035450638&partnerID=MN8TOARS.
    10.1086/322804
  88. Sousa, A.E.; Chaves, A.F.; Doroana, M.; Antunes, F.; Victorino, R.M.M.. "Bulk cytokine production versus frequency of cytokine-producing cells in HIV1 infection before and during HAART". Clinical Immunology 97 2 (2000): 162-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033778273&partnerID=MN8TOARS.
    10.1006/clim.2000.4930
  89. Nunes da Silva MJ; Oliveira V; Sousa AE; Lucas M; Victorino RM. "[Headaches, otalgia and peripheral facial palsy as a form of presentation of neurosyphilis]". (2000): http://europepmc.org/abstract/med/11055060.
  90. Cavaleiro, R.; Sousa, A.E.; Loureiro, A.; Victorino, R.M.M.. "Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity". AIDS 14 17 (2000): 2679-2686. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034492881&partnerID=MN8TOARS.
    10.1097/00002030-200012010-00007
  91. Sousa AE; Chaves AF; Doroana M; Antunes F; Victorino RM; Sousa, A.E.; Chaves, A.F.; et al. "Kinetics of the changes of lymphocyte subsets defined by cytokine production at single cell level during highly active antiretroviral therapy for HIV-1 infection.". Journal of immunology (Baltimore, Md. : 1950) 162 6 (1999): 3718-3726. http://europepmc.org/abstract/med/10092835.
  92. Sousa, A.E.; Chaves, A.F.; Doroana, M.; Antunes, F.; Victorino, R.M.M.. "Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: Possible implications for lymphocyte traffic and functional recovery". Clinical and Experimental Immunology 116 2 (1999): 307-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032894849&partnerID=MN8TOARS.
    10.1046/j.1365-2249.1999.00872.x
  93. Lucas, M.; Rebocho, L.; Sousa, A.E.; Palhano, M.J.; Victorino, R.M.M.. "Adenocarcinoma of the lung in HIV2 infection". European Journal of Internal Medicine 9 1 (1998): 49-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031812555&partnerID=MN8TOARS.
  94. Sousa, A.E.; Victorino, R.M.M.. "Single-cell analysis of lymphokine imbalance in asymptomatic HIV-1 infection: Evidence for a major alteration within the cd8+ T cell subset". Clinical and Experimental Immunology 112 2 (1998): 294-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031751013&partnerID=MN8TOARS.
    10.1046/j.1365-2249.1998.00585.x
  95. Sousa AE; Ventura F; Silva AC; Baptista A; Victorino RM; de Moura MC; Sousa, A.E.; et al. "Centrocytic lymphoma presenting as a subphrenic abscess and a solitary liver nodule.". Hepato-gastroenterology 44 15 (1997): 664-666. http://europepmc.org/abstract/med/9222667.
  96. Sousa, A.E.; Lucas, M.; Mayer da Silva, J.; Victorino, R.M.M.. "HIV2 infection and porphyria cutanea tarda". European Journal of Internal Medicine 7 1 (1996): 65-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029955703&partnerID=MN8TOARS.
  97. Maria VA; Pimpão MV; Carvalho ML; Sousa AE; Lucas MM; Victorino RM. "[The use of serological tests for detecting HIV infection in general clinical consultations and hospital consultations]". Acta medica portuguesa (1995): http://europepmc.org/abstract/med/8533615.
  98. Victorino RM; Sousa AE; Ruprecht, RuthM.; Baba, TimothyW.; Greene, MichaelF.; Almond, N.; Cranage, M.; et al. "Attenuated vaccines for AIDS.". Lancet (London, England) 346 8968 (1995): 177-179. http://europepmc.org/abstract/med/7603240.
    10.1016/s0140-6736(95)91235-5
  99. Sousa AE; Lucas M; Palhano MJ; de Deus J; Damião J; Victorino RM. "[Cytomegalovirus-induced colitis in HIV infection. Considerations on its diagnosis, treatment and complications]". Acta medica portuguesa (1995): http://europepmc.org/abstract/med/7625221.
  100. Sousa, A.E.; Lucas, M.; Palhano, M.J.; de Deus, J.; Damião, J.; Victorino, R.M.. "Cytomegalovirus-induced colitis in HIV infection. Considerations on its diagnosis, treatment and complications,Colite pelo citomegalovirus na infecção pelo VIH. Considerações sobre o diagnóstico, terapêutica e complicações.". Acta medica portuguesa 8 4 (1995): 247-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029284373&partnerID=MN8TOARS.
  101. Maria, V.A.; Pimpão, M.V.; Carvalho, M.L.; Sousa, A.E.; Lucas, M.M.; Victorino, R.M.. "The use of serological tests for detecting HIV infection in general clinical consultations and hospital consultations,Utilização de testes serológicos para detecção de infecção pelo VIH em consultas de clínica geral e em consultas hospitalares.". Acta médica portuguesa 8 10 (1995): 543-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-18344409680&partnerID=MN8TOARS.
  102. Sousa, A.E.; Lucas, M.; Victorino, R.M.; De Moura, M.C.. "Liver cirrhosis associated with severe haemolytic anaemia interstitial lung disease and autoimmune thyroiditis". European Journal of Gastroenterology and Hepatology 6 11 (1994): 1067-1069. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027997901&partnerID=MN8TOARS.
  103. Sousa, A.E.; Lucas, M.; Esperanca, P.; Victorino, R.M.M.. "Asymmetric paraparesis and hematologic autoimmune phenomena in HIV2 infection". European Journal of Internal Medicine 4 4 (1993): 333-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027882524&partnerID=MN8TOARS.
  104. Sousa, A.E.; Lucas, M.; Tavoral, I.; Victorino, R.M.M.. "Takayasu's disease presenting as a nephrotic syndrome due to amyloidosis". Postgraduate Medical Journal 69 812 (1993): 488-489. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027252603&partnerID=MN8TOARS.
    10.1136/pgmj.69.812.488
Capítulo de livro
  1. Foxall, Russell B.; Tendeiro, Rita; Sousa, Ana E.. "Role of Dendritic Cells in HIV-2 Pathogenesis". In Encyclopedia of AIDS, editado por Editors: Douglas D. Richman, Mario Stevenson and Thomas Hope. Section Editor: Sarah Rowland-Jones., 1-10. Springer New York, 2013.
    10.1007/978-1-4614-9610-6_37-1
  2. Ana Espada de Sousa. "VIH/SIDA: Imunopatogénese e Resposta Imunológica". In Manual sobre Sida. Lisboa, Portugal: Permanyer Portugal, 2011.
  3. Ana Espada de Sousa. "VIH/SIDA: Imunopatogénese e Resposta Imunológica.". In Manual sobre SIDA. Lisboa, Portugal: Permanyer, 2007.
    Publicado
  4. Ana Espada de Sousa. "VIH/SIDA: Imunopatogénese e Resposta Imunológica.". In Manual sobre SIDA. Lisboa, Portugal: Permanyer, 2004.
  5. Ana Espada de Sousa. "Reconstituição Imune com Tratamento Antirretroviral". In Biblioteca da SIDA, 3-39. Lisboa, Portugal: Edição Permanyer, 2001.
    Publicado
  6. Ana Espada de Sousa. "Citocinas e HIV - Revisitação do Tema através da Análise a Nível Celular Individualizado.". In 2º HIV/AIDS Virtual Congress http://www.aidscongress.net/article.php?sid=43.. 2001.
    Publicado
  7. Ana Espada de Sousa. "VIH/SIDA: Imunopatogénese e Resposta Imunológica.". In Manual sobre SIDA. l, Portugal: Permanyer, 2001.
    Publicado
Livro
  1. Ana Espada de Sousa. VIH/SIDA: Imunopatogénese e Resposta Imunológica.. Lisboa, Portugal: Permanyer. 2007.
    Publicado
Pré-impressão
  1. Stuchly, Jan; Novak, David; Brdickova, Nadezda; Hadlova, Petra; Iksi, Ahmad; Kuzilkova, Daniela; Svaton, Michael; et al. "Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus withtviblindi". 2023. http://dx.doi.org/10.1101/2023.07.13.547329.
    10.1101/2023.07.13.547329
  2. Raposo, Alexandre A. S. F.; Rosmaninho, Pedro; Silva, Susana L.; Paço, Susana; Brazão, Maria E.; Godinho-Santos, Ana; Tokunaga, Yumie; et al. "Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells". 2023. http://dx.doi.org/10.1101/2023.12.27.573411.
    10.1101/2023.12.27.573411
  3. Manuel M Vicente; Inês Alves; Ângela Fernandes; Ana M Dias; Elena Pérez-Anton; Alexandra Correia; Afonso R M Almeida; et al. "N-glycans mannosylation controls T-cell development by reprogramming thymocyte commitment, fate and repertoire". 2022. https://doi.org/10.1101/2022.02.04.22270265.
    10.1101/2022.02.04.22270265
Tese / Dissertação
  1. Ana Espada de Sousa. "Two clinical models in the investigation of AIDS pathogenesis: The post-HAART immune reconstitution and the HIV2 infection.". Doutoramento, Faculdade de Medicina da Universidade de Lisboa, 2000.

Propriedade Intelectual

Pedido provisório de patente
  1. 2023. "Genomic Mutations".
    Protegido
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017 - Atual Gene therapy for HIV cure using RNA replicons
Coorientador
 Microbiology (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - Atual Bioengineered approaches for the manufacture of an artificial human thymus mimicking device
Coorientador
 Bioengineering
MIT Portugal Program, Portugal
2021/03/01 - 2025/02/28 Deciphering complex inborn errors of immunity through the integration of clinical data, high-dimensional immune profile and whole-genome sequencing
Coorientador de Adriana Motta Raymundo
 CAML PhD (Doutoramento)
Instituto de Medicina Molecular, Portugal
2020/09/01 - 2024/08/31 Revealing lung repair after ARDS through the IL-22 path
Coorientador de André Miguel Carapinha Gomes
 CAML PhD (Doutoramento)
Instituto de Medicina Molecular, Portugal
2017 - 2018 Human regulatory vs conventional T cells: a transcriptomic analysis
Coorientador
 Biologia Molecular e Celular (Mestrado)
Universidade de Coimbra, Portugal
2012 - 2016 Living without thymus: lessons from adults thymectomized in early infancy.
Orientador
 Clinical Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2011 - 2015 HIV Infection and Gut-Associated Lymphoid Tissue.
Orientador
 Clinical Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2008 - 2012 B cells at the crossroad of immune responses: insights from primary B-cell immunodeficiencies
Orientador
 Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2007 - 2012 HIV-2 immunopathology: how the immune system deals with long-lasting infection.
Orientador
 Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2006 - 2011 Papel da carga viral celular na imunodeficiência HIV/SIDA: contributo do estudo da infecção pelo HIV-2.
Orientador
 Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2006 - 2010 Development of regulatory T cells in the human thymus: one step beyond.
Orientador
 Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2006 - 2010 Strategies for T-cell reconstitution: insights from human clinical models.
Orientador
 Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2005 - 2009 HIV-specific responses, T-cell activation and regulatory T-cells in AIDS pathogenesis: lessons from the HIV-2 model.
Orientador
 Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2005 - 2009 Modulação de Células Dendríticas e Monócitos pelo Vírus da Imunodeficiência Humana Tipo 2.
Orientador
 Immunolgy (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2004 - 2009 Title: Studies on a human model and a murine model of immunodeficiency: HIV-2 infection and TACI deficiency.
Orientador
 Immunology (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/06/11 - 2019/06/12 HIV Pathogenesis: Lessons from HIV-2. ANRS AC41 International Workshop, Paris, France, June 11-12, 2019. (2019/06/11 - 2019/06/12)
Conferência (Membro da Comissão Organizadora)
 Agence Nationale de Recherches sur le SIDA et les Hépatites Virales, França
2019 - 2019 26th International HIV Dynamics & Evolution, Cascais, Portugal, March 24-27, 2019. (2019/03/24 - 2019/03/27)
Conferência (Membro da Comissão Organizadora)
 UC San Diego School of Medicine Continuing Medical Education, Estados Unidos

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2018 - Atual Member of the referee panel for evaluation of research projects in Medicine, Health Sciences and Biology Research Council of Norway (RCN), Norway
Avaliador
 Research Council of Norway (RCN), Noruega Research Council of Norway (RCN)
2010 - Atual Peer-Review of Grants/ Positions, namely for FCT, Welcome Trust UK, NIH, Multiple Sclerosis Research Australia, British HIV Association, Israel Science Foundation
Avaliador
2005 - Atual Peer-Review Activity for several journals including: Journal of Clinical Investigation; Blood; Journal of Immunology; Clinical Immunology; Clinical and Experimental Immunology; Retrovirology; Viral Immunology; AIDS; JAIDS; AIDS Research and Human Retrovirology; Expert Review of Anti-infective Therapy; Clinical and Experimental Allergy; Journal of Immunology Methods; Journal of Infectious Diseases
Avaliador
2014 - 2017 Coordinator of the FCT Board of Evaluators of the Final Project Reports of the area of Diagnosis, Therapeuthic and Public Health.
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2015 - 2015 Member of the evaluation committee of the research unit Centre International de recherche en infectiologie (CIRI), at Lyon – CIRI to be coordinated by HCERES – Haute conseil de l’evaluation de la recherche et de l’enseignement supérieur
Avaliador
 HCERES – Haute conseil de l’evaluation de la recherche et de l’enseignement supérieur, França HCERES – Haute conseil de l’evaluation de la recherche et de l’enseignement supérieur
2007 - 2012 Member of the FCT board of evaluation of PhD and Post-Doc scholarship applications
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018 - Atual Master-course Clinical Microbiology and Emerging Infectious Diseases Clinical Immunology (Mestrado) Faculdade de Medicina da Universidade de Lisboa, Portugal
2015 - Atual Clinical Immunology / Medicina 2 - 5th year of the Medical Course - Faculdade de Medicina da Universidade de Lisboa Estudos Básicos de Medicina Faculdade de Medicina da Universidade de Lisboa, Portugal
2014 - Atual Immunology course for the PhD program LisbonBioMed and PhD program of the Lisbon Academic Medical Course Immunology (Curso de doutoramento (conclusão de unidades curriculares)) Faculdade de Medicina da Universidade de Lisboa, Portugal

Instituto de Medicina Molecular, Portugal
1996 - Atual Clinical Immunology - optative discipline of the Medical Course - Faculdade de Medicina da Universidade de Lisboa Clinical Immunology (Mestrado integrado) Faculdade de Medicina da Universidade de Lisboa, Portugal

Membro de associação

Nome da associação Tipo de participação
2018 - Atual EFIS-Immunology Letters (IL) Study Group titled “T_CELL_CONNECT_EUROPE”, European Federation of Immunology Societies (EFIS). https://www.efis.org/efis-support/efis-il-study-groups/index.html member
2015 - Atual Euroflow Consortium https://euroflow.org/ Member and currently part of the Euroflow Board
2014 - Atual International AIDS Society (IAS) member
2006 - Atual European Society for Immunodeficiency (ESID) Member
1996 - Atual The American Association of Immunologists (AAI) member
1990 - Atual Portuguese Society for Immunology Member and Presidente from 2009-12
1990 - Atual Sociedade de Ciências Médica de Lisboa, Portugal Member and Member of the Directive Board, Treasurer 2009-2013
1990 - Atual Sociedade Portuguesa de Medicina Interna member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2018 - Atual Member of the Conselho Consultivo do GAT - Grupo de Ativistas em Tratamentos (www.gatportugal.org), a NGO with main participation of people living with HIV.
Consultor
 Grupo de Ativistas em Tratamentos, Portugal
2017 - Atual Member of the Exceutive Board of the National Ethics Committee for Clinical Research, Portugal
Membro
 National Ethics Committee for Clinical Research, Portugal
2016 - Atual Member of the "Comissão de Avaliação de Tecnologias de Saúde (CATS)" INFARMED, Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
Membro
 Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2015 - Atual Member of the Biosciences Scientific Board Santa Casa da Misericórdia de Lisboa, Portugal
Membro
 Santa Casa da Misericórdia de Lisboa, Portugal
2014 - Atual Member of the National Ethics Committee for Clinical Research, Portugal
Membro
 National Ethics Committee for Clinical Research, Portugal
2014 - Atual Member of the Board of the LisbonBioMed - FCT PhD Program Instituto de Medicina Molecular, Portugal
Membro
 Instituto de Medicina Molecular, Portugal
2010 - Atual Member of the Scientific Board of the Lisbon Medical Academic Center (AMC) Doctoral Programme
Membro
 Faculdade de Medicina da Universidade de Lisboa, Portugal
2009 - Atual Member of the Scientific Council (Management of the Scientific Area of the Medical School) Faculdade de Medicina da Universidade de Lisboa, Portugal
Membro
 Faculdade de Medicina da Universidade de Lisboa, Portugal
2012 - 2014 Board of Education & Advanced Training
Coordenador
 Instituto de Medicina Molecular, Portugal

Tutoria

Tópico Nome do aluno
2014 - Atual Master thesis of medical students Several medical students
2010 - Atual Research initiation for medical students through annual projects funded by GAPIC Several MD Students
2004 - Atual Laboratory and research training, as part as of the residency in the medical speciality of Immunolallergology, Several MDs form different hospitals
2002 - Atual Post- doctoral and career development Several PhDs
1996 - Atual Training in Clinical Immunology of physicians during their general internship training or residency in Internal Medicine Several MDs
Distinções

Prémio

2019 Prémio de Investigação em Autoimunidade NEDAI 2018
Sociedade Portuguesa de Medicina Interna, Portugal
2015 Prémio NEDAI de Investigação Básica em Autoimunidade
Sociedade Portuguesa de Medicina Interna, Portugal
2012 Prémio NEDAI de Investigação Básica em AutoImunidade 2012
Sociedade Portuguesa de Medicina Interna, Portugal
2008 Prémio Pfizer de Investigação Clínica
Sociedade de Ciências Médica de Lisboa, Portugal
2005 Prémio de Investigação Bristol-Myers Squibb em Infecção por Virus da Imunodeficiência Humana
Associação Portuguesa para o Estudo Clínico da SIDA (APECS), Portugal
2004 AMI – Saúde / Doenças Infecciosas e Parasitárias – Menção Honrosa
AMI - Associação Médica Internacional, Portugal
2004 Estudos VIH - Glaxo-Smith Kline
Sociedade Portuguesa de Medicina Interna, Portugal
2003 Prémio LabMed Saúde - 1ª Menção Honrosa
Laboratório LabMed, Portugal
2002 Prémio Dr. José Luís Champalimaud - Investigação aplicada
Direcção-Geral da Saúde, Portugal
2002 Prémio Dr. José Luís Champalimaud - Investigação Básica (Menção Honrosa).
Direcção-Geral da Saúde, Portugal
1998 Prémio Pfizer (Menção Honrosa)
Sociedade de Ciências Médica de Lisboa, Portugal

Outra distinção

2005 Projecto de Investigação Astra-Zeneca
Fundação Astra-Zeneca, Portugal