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Maria João Ramalho obtained her PhD in Biological and Chemical Engineering from the Faculty of Engineering of University of Porto in 2019. Her thesis focused on the development of efficient nanocarriers to deliver drugs to the brain for the treatment of brain tumours. Her PhD thesis work was distinguished with a 20,000 euros prize (Maratona da Saúde Prizes 2019 - Cancer Research). MJ Ramalho also holds a BsC in Biochemistry (FCUP, 2012) and MsC degree in Biomedical Engineering (FEUP, 2014). MJ Ramalho is currently a Junior Researcher at LEPABE (Laboratory for Process Engineering, Environment, Biotechnology and Energy)/ALICE - Associate Laboratory for Innovation in Chemical Engineering, and a visiting researcher at i3S (Institute for Research and Innovation in Health, University of Porto). In 2021, MJ Ramalho was awarded with a 6-year CEEC contract position atributed by a FCT international jury (4th editition of Individual Call to Scientific Employment Stimulus). Her main areas of expertise are the design, optimization, characterization and in vitro and in vivo evaluation of nanoparticles for the encapsulation of bioactive compounds for several health applications. In last years, M J Ramalho has focused on the drug delivery to the brain for the treatment of brain disorders, such as brain tumours, mainly Glioblastoma Multiforme; and neurodegenerative diseases such as Alzheimer Disease. M J Ramalho also focus in drug-membrane interaction studies using in vitro models, and the role of those interactions on drugs' bioavailability and in vivo behaviour. Her research interests also include the exploitation of the benefic effects of natural compounds, and the enhancement of their properties by nanoencapsulation for food and therapeutic applications. She is successfully co-supervised 3 master students , and at this moment she is currently co-supervising other 6 master students. MJ Ramalho (h-index 14) is the author of 24 papers in international journals, and 2 conference papers and 4 book chapters. Some of MJ Ramalho articles have been published in the Top 10% journals in the Scopus in category "Pharmacology, Toxicology and Pharmaceutics -Pharmaceutical Science". She co-editied two speciel issues for Pharmaceutics ("Alzheimer's Disease: An Update on Novel Therapeutics"; "Functional Polymeric Nanoparticles for Enhanced Cancer Therapy" ) and one for Polymers ("Polymeric Nanoparticles for Biomedical Applications"). MJ Ramalho has presented her work in more than 17 international conferences. MJ Ramalho has been involved in 10 financed research projects, and received 3 research grants from 3 funded projects and 1 FCT doctoral scholarship. MJ Ramalho is currently the co-PI of a FCT project funded in the 2021Call for SR&TD Project Grants in all Scientific Domains (EXPL/NAN-MAT/0209/2021). She is also team member of project funded in the M-ERA.NET Joint Call 2021(M-ERA-NET3/0001/2021). MJ Ramalho is co-founder of a patent (title: Process for preparing lipid nanoparticles based on matrix containing liquid and solid lipids to be used in drug delivery of levodopa and other active molecules to target the brain; Provisional patent application No. 118297). MJ Ramalho is currently member of the Reviewers Board of "Polymers" and "Pharmaceuticals" and a Topic Editor of "Pharmaceutics". MJ Ramalho also reviews articles for several other international journals. MJ Ramalho is member of the organizing committee of the symposium on Alzheimer's disease. MJ Ramalho is also part of the nanotechnology team from FEUP at Junior University of Porto.
Identificação

Identificação pessoal

Nome completo
Maria João Alves Ramalho

Nomes de citação

  • Maria João Ramalho

Identificadores de autor

Ciência ID
D011-9DD8-9D62
ORCID iD
0000-0003-2428-7520
Researcher Id
C-5579-2019
Scopus Author Id
56642479900

Endereços de correio eletrónico

  • mjaramalho@gmail.com (Profissional)

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial
  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Bioprodutos Biomateriais
  • Ciências da Engenharia e Tecnologias - Engenharia Química
  • Ciências da Engenharia e Tecnologias - Engenharia Médica
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C2)
Alemão Utilizador elementar (A2) Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A2)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2021/09/07 - 2021/12/30
Concluído
HiEngine (Outros)
HiSeedTech - Associação para a Valorização do Conhecimento, Portugal, Portugal
2021/03/10 - 2021/07/18
Concluído
HiTech (Outros)
HiSeedTech - Associação para a Valorização do Conhecimento, Portugal, Portugal
2019/02 - 2019/04
Concluído
Introductory course in Laboratory Animal Science. Species specific in mice and rats. Functions A and D – directive 2010/63/EU. (Outros)
I3S - Institute for Research and Innovation in Health, University of Porto, Portugal
2015/02 - 2019/02/08
Concluído
Doctoral Program in Chemical and Biological Engineering (Doctor)
Faculty of Engineering of University of Porto, Portugal
"Bioengineered nanocarriers for targeted drug delivery in glioblastoma multiforme therapy" (TESE/DISSERTAÇÃO)
2012/09 - 2014/06
Concluído
Master in Biomedical Engineering (Master)
Faculty of Engineering of University of Porto, Portugal
"PLGA Nanoparticles as a platform for Vitamin D -based cancer therapy" (TESE/DISSERTAÇÃO)
18
2007/09 - 2012/02
Concluído
Biochemistry degree (Licenciatura)
FCUP - Faculty of Sciences of the University of Porto, Portugal
"Antioxidant therapy in Alzheimer's Disease" (TESE/DISSERTAÇÃO)
14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2021/06/01 - Atual Investigador Contratado (Investigação) ALICE – Associate Laboratory for Innovation in Chemical Engineering, Portugal
Universidade do Porto Faculdade de Engenharia, Portugal
2021/01 - Atual Investigador Contratado (Investigação) LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Universidade do Porto Faculdade de Engenharia, Portugal
2016/05 - Atual Investigador visitante (Investigação) I3S - Institute for Research and Innovation in Health, University of Porto, Portugal
2019/03 - 2021/01/31 Pós-doutorado (Investigação) LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
2013/02 - 2019/02 Investigador (Investigação) LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
2014/03 - 2015/12 Investigador visitante (Investigação) IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Portugal
2011/02/01 - 2011/03/01 Estagiário de Investigação (Investigação) CIQUP Center for Investigation in Chemistry of University of Porto, Portugal
FCUP - Faculty of Sciences of the University of Porto, Portugal
Projetos

Bolsa

Designação Financiadores
2019/10/01 - 2020/12/31 MB-37-2017_Prémio_Mantero_Belard: “Novel therapeutic strategy and new biomarker for Alzheimers´s Disease based on BDNF receptor cleavage”
FEUP-Bolsa-BDNF
Bolseiro de Pós-Doutoramento
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Santa Casa da Misericórdia de Lisboa
Em curso
2019/04 - 2019/09/30 Project “LEPABE-2-ECO-INNOVATION” – NORTE-01-0145-FEDER-000005, (from NORTE 2020 and ERDF)
LEPABE-2-ECO-basenanotecnologica
Bolseiro de Pós-Doutoramento
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
North Regional Coordination and Development Commission
Concluído
2019/02/01 - 2019/03/31 Project “LEPABE-2-ECO-INNOVATION” – NORTE-01-0145-FEDER-000005, (from NORTE 2020 and ERDF)
LEPABE-NANO-1
Bolseiro de Investigação
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
North Regional Coordination and Development Commission
Concluído
2015/02 - 2019/02 FCT PhD - Scholarship SFRH/PD/BD/105984/2014
SFRH/PD/BD/105984/2014
Bolseiro de Doutoramento
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Foundation for Science and Technology (FCT)
2014/10 - 2015/01 Functionalized liposomes with antibodies for Alzheimer's disease
FEUP-SR-PTDC/QUI-BIQ/118076/2010
Bolseiro de Investigação
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Foundation for Science and Technology (FCT)

Projeto

Designação Financiadores
2022/08/01 - Atual 4th edition of CEEC Call: Nano-Therapy for Glioblastoma Multiforme: engineered nanoparticles to overcome drug resistance mechanisms
2021.01741.CEECIND
Investigador
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Rua Doutor Roberto Frias, University of Porto, Portugal
Foundation for Science and Technology (FCT)
Em curso
2021/08/02 - 2022/07/31 2SMART - engineered Smart materials for Smart citizens
NORTE-01-0145-FEDER-000054
Investigador
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Em curso
2021/02/01 - 2021/07/31 Multi-annual funding of R&D Units LEPABE 2020-2023
UIDB/00511/2020_UIDP/00511/2020
Investigador
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Em curso

Outro

Designação Financiadores
2022/08/01 - Atual M-ERA-NET3/0001/2021 -Engineered nano-based device for glioblastoma multiforme therapy
M-ERA-NET3/0001/2021
Investigador
Faculty of Engineering of University of Porto, Portugal
Em curso
2022/01/01 - Atual Co-Principal Investigator on the project Nanotech-double functionalized particles to transport Nucleic Acid Mimics against Staphylococcus Aureus
EXPL/NAN-MAT/0209/2021
Co-Investigador Responsável (Co-IR)
2021/11 - Atual Bioengineered nanocarriers for targeted drug delivery in glioblastoma multiforme therapy
Investigador
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Associação Maratona da Saúde
Em curso
2019/01/01 - 2019/12/19 UID/EQU/00511/2019 - Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE
UID/EQU/00511/2019
Investigador
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Foundation for Science and Technology (FCT)
2016 - 2018/12/31 UID/EQU/00511/2013 - Laboratory for Process Engineering, Environment, Biotechnology and Energy
UID/EQU/00511/2013
Investigador
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Foundation for Science and Technology (FCT)
Concluído
2015/04/24 - 2017/04 Nanoparticle-Enhanced molecular Fluorescence-Endoscopy for detection of early-stage colorectal adenocarcinomas
Investigador
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Portugal
Foundation for Science and Technology (FCT)
Produções

Publicações

Artigo em conferência
  1. Maria João Ramalho; Joana A. Loureiro; Jorge Lima; Manuel A.N. Coelho; Maria do Carmo Pereira. "Anti-transferrin receptor antibody conjugated PLGA nanoparticles for temozolomide delivery". Trabalho apresentado em 19th International Union of Pure and Applied Biophysics (IUPAB) and 11th European Biophysical Societies' Association (EBSA) Congress, Edinburgh, 2017.
    Publicado • 10.1007/s00249-017-1222-x
  2. Maria João Ramalho; Joana A Loureiro; Bárbara Gomes; Manuela F Frasco; Manuel A.N. Coelho; Maria do Carmo Pereira. "PLGA nanoparticles for calcitriol delivery". Trabalho apresentado em 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG), Porto, 2015.
    Publicado • 10.1109/enbeng.2015.7088884
Artigo em revista
  1. Stéphanie Andrade; Débora Nunes; Meghna Dabur; Maria João Ramalho; Maria do Carmo Pereira; Joana A. Loureiro. "Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/1/212.
    10.3390/pharmaceutics15010212
  2. Andrade, Stéphanie; Ramalho, Maria J.; Loureiro, Joana A.; Pereira, Maria C.. "Transferrin-functionalized liposomes loaded with vitamin VB12 for Alzheimer's disease therapy". International Journal of Pharmaceutics 626 (2022): 122167. http://dx.doi.org/10.1016/j.ijpharm.2022.122167.
    10.1016/j.ijpharm.2022.122167
  3. Torres, Inês David; Loureiro, Joana Angélica; Coelho, Manuel A N; Carmo Pereira, Maria; Ramalho, Maria João. Autor correspondente: Ramalho, Maria João. "Drug delivery in glioblastoma therapy: a review on nanoparticles targeting MGMT-mediated resistance". Expert Opinion on Drug Delivery 19 11 (2022): 1397-1415. http://dx.doi.org/10.1080/17425247.2022.2124967.
    10.1080/17425247.2022.2124967
  4. Maria João Ramalho; Stéphanie Andrade; Joana A. Loureiro; Maria do Carmo Pereira. Autor correspondente: Maria João Ramalho. "Interaction of Bortezomib with Cell Membranes Regulates Its Toxicity and Resistance to Therapy". Membranes (2022): https://www.mdpi.com/2077-0375/12/9/823.
    10.3390/membranes12090823
  5. Ramalho, Maria João; Bravo, Maria; Loureiro, Joana Angélica; Lima, Jorge; Pereira, Maria Carmo. "Transferrin-modified nanoparticles for targeted delivery of Asiatic acid to glioblastoma cells". Life Sciences 296 (2022): 120435. http://dx.doi.org/10.1016/j.lfs.2022.120435.
    Publicado • 10.1016/j.lfs.2022.120435
  6. Débora Nunes; Andrade, Stephanie; Maria João Ramalho; Joana Angélica Loureiro; Maria do Carmo Pereira. "Polymeric nanoparticles-loaded hydrogels for biomedical applications: A systematic review on in vivo findings". Polymers 14 5 (2022): 1-28. SECOND AUTHOR - S. Andrade and M.J. Ramalho contributed equally to this work https://www.mdpi.com/2073-4360/14/5/1010.
    Publicado
  7. Débora Nunes; Stéphanie Andrade; Maria João Ramalho; Joana A. Loureiro; Maria do Carmo Pereira. "Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings". Polymers (2022): https://www.mdpi.com/2073-4360/14/5/1010.
    10.3390/polym14051010
  8. Maria João Ramalho; Joana Loureiro; Manuel A. N. Coelho; Maria do Carmo Pereira. "Transferrin Receptor-Targeted Nanocarriers: Overcoming Barriers to Treat Glioblastoma". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/2/279.
    10.3390/pharmaceutics14020279
  9. Adriana Pereira; Maria João Ramalho; Renata Silva; Vera Silva; Rita Oliveira; Ana Catarina Silva; Maria do Carmo Pereira; Joana Loureiro. "Vine Cane Compounds to Prevent Skin Cells Aging through Solid Lipid Nanoparticles". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/2/240.
    10.3390/pharmaceutics14020240
  10. Loureiro, Joana A.; Andrade, Stephanie; Ramalho, Maria João; Oliveira, Nuno; Pereira, Maria Carmo. "The interaction of a ß2 adrenoceptor agonist drug with biomimetic cell membrane models: The case of terbutaline sulphate". Life Sciences 285 (2021): 119992. http://dx.doi.org/10.1016/j.lfs.2021.119992.
    10.1016/j.lfs.2021.119992
  11. Catarina Gonçalves; Maria João Ramalho; Renata Silva; Vera Silva; Rita Oliveira; Ana Catarina Silva; Maria do Carmo Pereira; Joana Loureiro. "Lipid Nanoparticles Containing Mixtures of Antioxidants to Improve Skin Care and Cancer Prevention". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/12/2042.
    10.3390/pharmaceutics13122042
  12. Andrade, Stéphanie; Ramalho, Maria J.; Loureiro, Joana A.; Pereira, Maria C.. "Liposomes as Biomembrane Models: Biophysical techniques for Drug-Membrane Interaction Studies". Journal of Molecular Liquids (2021): 116141. FIRST AUTHOR - S. Andrade and M.J. Ramalho contributed equally to this work. http://dx.doi.org/10.1016/j.molliq.2021.116141.
    Publicado • 10.1016/j.molliq.2021.116141
  13. Ramalho, Maria João; Loureiro, Joana Angélica; Pereira, Maria Carmo. "Poly(lactic-co-glycolic acid) Nanoparticles for the Encapsulation and Gastrointestinal Release of Vitamin B9 and Vitamin B12". ACS Applied Nano Materials 4 7 (2021): 6881-6892. http://dx.doi.org/10.1021/acsanm.1c00954.
    Publicado • 10.1021/acsanm.1c00954
  14. Stéphanie Andrade; Maria João Ramalho; Joana Angélica Loureiro; Maria do Carmo Pereira. "The biophysical interaction of ferulic acid with liposomes as biological membrane model: The effect of the lipid bilayer composition". Journal of Molecular Liquids (2020): 114689. http://dx.doi.org/10.1016/j.molliq.2020.114689.
    Publicado • 10.1016/j.molliq.2020.114689
  15. Maria João Ramalho; Stéphanie Andrade; Manuel A.N. Coelho; Joana A. Loureiro; Maria do Carmo Pereira. "Molecular interactions between Vitamin B12 and membrane models: A biophysical study for new insights into the bioavailability of Vitamin". Colloids and Surfaces B: Biointerfaces 194 (2020): 111187. http://dx.doi.org/10.1016/j.colsurfb.2020.111187.
    Publicado • 10.1016/j.colsurfb.2020.111187
  16. Joana A Loureiro; Maria João Ramalho; Maria do Carmo Pereira. "Immuno-nanocarriers for brain delivery: limitations from in vitro to preclinical and clinical studies". Nanomedicine (2020): http://dx.doi.org/10.2217/nnm-2019-0402 - FIRST AUTHOR - J. Loureiro and M.J. Ramalho contributed equally to this work.
    Publicado • 10.2217/nnm-2019-0402
  17. Maria João Ramalho; Stephanie Andrade; Joana Angélica Loureiro; Maria do Carmo Pereira. "Nanotechnology to improve the Alzheimer's disease therapy with natural compounds". Drug Delivery and Translational Research (2019): 1-23. http://dx.doi.org/10.1007/s13346-019-00694-3.
    Publicado • 10.1007/s13346-019-00694-3
  18. Maria João Ramalho; Joana Angélica Loureiro; Manuel A.N. Coelho; Maria do Carmo Pereira. "Factorial Design as a Tool for the Optimization of PLGA Nanoparticles for the Co-Delivery of Temozolomide and O6-Benzylguanine.". Pharmaceutics 11 8 (2019): 401. https://www.mdpi.com/1999-4923/11/8/401.
    Publicado • 10.3390/pharmaceutics11080401
  19. Stephanie Andrade; Maria João Ramalho; Joana Angélica Loureiro; Maria do Carmo Pereira. "Natural Compounds for Alzheimer's Disease Therapy: A Systematic Review of Preclinical and Clinical Studies". International Journal of Molecular Sciences 20 9 (2019): 2313. https://www.mdpi.com/1422-0067/20/9/2313.
    Publicado • 10.3390/ijms20092313
  20. Stéphanie Andrade; Maria João Ramalho; Joana Angélica Loureiro; Maria do Carmo Pereira. "Interaction of natural compounds with biomembrane models: A biophysical approach for the Alzheimer's disease therapy.". Colloids and surfaces. B, Biointerfaces (2019): https://www.sciencedirect.com/science/article/abs/pii/S0927776519302425?via%3Dihub.
    Publicado • 10.1016/j.colsurfb.2019.04.019
  21. Maria João Ramalho; Stéphanie Andrade; Manuel Álvaro Neto Coelho; Joana Angélica Loureiro; Maria do Carmo Pereira. "Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug-membrane interaction for Glioblastoma Multiforme therapy". European Journal of Pharmaceutics and Biopharmaceutics 136 (2019): 156-163. https://doi.org/10.1016/j.ejpb.2019.01.015.
    Publicado • 10.1016/j.ejpb.2019.01.015
  22. Stephanie Andrade; Maria João Ramalho; Maria do Carmo Pereira; Joana A. Loureiro. "Resveratrol brain delivery for neurological disorders prevention and treatment". Frontiers in Pharmacology 9 1261 (2018): FIRST AUTHOR - S. Andrade and M.J. Ramalho contributed equally to this work - https://doi.org/10.3389/fphar.2018.01261.
    Acesso aberto • Publicado • 10.3389/fphar.2018.01261
  23. Maria João Ramalho,; Emmanuel Sevin; Fabian Gosselet; Jorge Lima; Manuel A.N. Coelho; Joana Angélica Loureiro; Maria do Carmo Pereira. "Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment". International Journal of Pharmaceutics 545 1-2 (2018): 84-92. https://doi.org/10.1016/j.ijpharm.2018.04.062.
    Publicado • 10.1016/j.ijpharm.2018.04.062
  24. Maria João Ramalho; Maria do Carmo Pereira. "Preparation and Characterization of Polymeric Nanoparticles: An Interdisciplinary Experiment". Journal of Chemical Education 93 8 (2016): 1446-1451. https://doi.org/10.1021/acs.jchemed.5b00837.
    Publicado • 10.1021/acs.jchemed.5b00837
  25. Maria João Ramalho; Joana Angélica Loureiro; Bárbara Gomes; Manuela F Frasco; M.A.N. Coelho; Maria do Carmo Pereira. "PLGA nanoparticles as a platform for vitamin D-based cancer therapy". Beilstein Journal of Nanotechnology 6 1 (2015): 1306-1318. https://www.beilstein-journals.org/bjnano/articles/6/135.
    Acesso aberto • Publicado • 10.3762/bjnano.6.135
Capítulo de livro
  1. Maria João Ramalho; Andrade, Stephanie; Dabur, Meghna; Joana Angélica Loureiro; Carmo Pereira, Maria. "Current vs Emerging Natural Compounds-Based Treatments for Alzheimers Disease". In Alzheimer's Disease and Treatment, 26-30. MedDocs Publishers, 2021.
    Publicado
  2. Stéphanie Andrade; Maria João Ramalho; Joana Angélica Loureiro; Maria do Carmo Pereira. "Techniques to produce liposomes for the emerging market of nano-based formulations". In Importance & Applications of Nanotechnology. Reno, Estados Unidos: MedDocs Publishers, 2020.
    Publicado
  3. Maria João Ramalho; Manuel A.N Coelho; Maria do Carmo Pereira. "Nanocarriers for the delivery of temozolomide in the treatment of gliobastoma: a review". In Design and Development of New Nanocarriers, editado por Alexandru Mihai Grumezescu, 687-722. Elsevier, 2018.
    Publicado • 10.1016/B978-0-12-813627-0.00018-1
  4. Maria João Ramalho; Manuel A.N Coelho; Maria do Carmo Pereira. "Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities". In A Critical Evaluation of Vitamin D - Clinical Overview, editado por Sivakumar Gowder, 231-249. InTech, 2017.
    Publicado • 10.5772/64516
Edição de número de revista
  1. Maria do Carmo Pereira; Joana Angélica Loureiro; Maria João Ramalho; Andrade, Stéphanie. "Alzheimer's Disease: An Update on Novel Therapeutics". Pharmaceutics (2023): https://www.mdpi.com/journal/pharmaceutics/special_issues/1X08D0Z9Q0.
    No prelo • Editor
  2. Andrade, Stephanie; Joana Angélica Loureiro; Maria João Ramalho. "Polymeric Nanoparticles for Biomedical Applications". Polymers (2022):
    No prelo
  3. Maria João Ramalho; Maria do Carmo Pereira. "Functional Nanoparticles for Enhanced Cancer Therapy". Pharmaceutics (2022): https://www.mdpi.com/journal/pharmaceutics/special_issues/Polymeric_Cancer_Therapy.
    No prelo
Poster em conferência
  1. Andrade, Stephanie; Maria João Ramalho; Álvaro Neto Coelho, Manuel; Joana Angélica Loureiro; Carmo Pereira, Maria do. "Targeting alzheimer’s disease with natural compounds-based nanomedicine". Trabalho apresentado em AD/PD 2023: 17th International Conference on Alzheimer’s and Parkinson’s Diseases, 2023.
  2. Maria João Ramalho; Stephanie Andrade; Joana A. Loureiro; Álvaro Neto Coelho, Manuel; Maria do Carmo Pereira. "Nanoparticles for biomedical applications: Nanocarriers and biomembranes for cancer and neurodegeneration.". Trabalho apresentado em 17th annual event of European Technology Platform on Nanomedicine (ETPN), 2022.
  3. Joana Loureiro; Stephanie Andrade; Maria João Ramalho; Maria do Carmo Pereira. "Biomembranes as cell models for drug screening based on the drug partitions coefficients". Trabalho apresentado em 11th International Colloids Conference, 2022.
  4. Inês Torres; Joana A. Loureiro; Maria João Ramalho; Maria do Carmo Pereira. "Resistance-targeting nanoparticles for glioblastoma therapy". Trabalho apresentado em 11th International Colloids Conference, 2022.
  5. Maria João Ramalho; Joana Angélica Loureiro; Manuel A.N. Coelho; Maria do Carmo Pereira. "The use of nanomaterials for cancer and neurodegeneration: nanocarriers, biomembranes and immunosensors". Trabalho apresentado em NanoMed Europe, 2019.
  6. Maria João Ramalho; Stephanie Andrade; Jorge Lima; Manuel A.N. Coelho; Joana A. Loureiro; Maria do Carmo Pereira. "Solid Lipid Nanoparticles for Glioblastoma Multiforme therapy". Trabalho apresentado em 3rd ASPIC International Congress, 2018.
  7. Maria João Ramalho; Joana A. Loureiro; Jorge Lima; Manuel A.N. Coelho; Maria do Carmo Pereira. "Anti-transferrin receptor antibody conjugated PLGA nanoparticles for temozolomide delivery". Trabalho apresentado em 19th International Union of Pure and Applied Biophysics (IUPAB) and 11th European Biophysical Societies' Association (EBSA) Congress, 2017.

Propriedade Intelectual

Pedido provisório de patente
  1. 2022. "Process for preparing lipid nanoparticles based on matrix containing liquid and solid lipids to be used in drug delivery of levodopa and other active molecules to target the brain".
    Divulgado

Outros

Técnica de investigação
  1. I developed an experimental protocol to be applied in practical classes of a nanotechnology course for graduate students of Faculty of Engineering of University of Porto. The protocal was successfully conducted by 24 graduate students. The protocol, as the student's obtained resuls and pedagogical assessment were published.. Investigador. Ramalho, Maria João.
    https://doi.org/10.1021/acs.jchemed.5b00837 • Investigador
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/05/04 Tumor-Targeting Functional Nanoparticles for Cancer Therapy 15th Encontro de Investigação Jovem (IJUP)
University of Porto (porto, Portugal)
2022/03/15 The anti-amyloidogenic activity of caffeic acid in a neuronal membrane-like environment: relevance for the alzheimer's disease AD/PD™ Barcelona, 2022: Alzheimer's & Parkinson's Diseases Congress
(Barcelona, Espanha)
2022/03/15 The anti-amyloidogenic activity of caffeic acid in a neuronal membrane-like environment: Relevance for Alzheimer’s disease AD/PD 2022: 16th International Conference on Alzheimer’s and Parkinson’s Diseases
(Barcelone, Espanha)
2021/09/23 Engineered nanoparticles for targeted brain delivery LEPABE TALK - 37º editon
LEPABE (Porto, Portugal)
2021/05/05 Nanoparticles for targeted drug delivery in glioblastoma multiforme therapy IJUP 2021
2021/05/05 The use of SLN and NLC to improve the efficacy of antioxidant molecules in the skin care IJUP 2021
(Portugal)
2021/05/05 Using nanotechnology to prevent skin aging IJUP 2021
(Portugal)
2019/03 Liposomes based nanocarriers to transport drugs in AD/PD treatment AD/PD™ Lisbon, 2019: Alzheimer's & Parkinson's Diseases Congress
(Lisbon, Portugal)
2018/10 Conjugation with anti-transferrin receptor antibody increases PLGA nanoparticles uptake in Glioblastoma cells NanoMedicine International Conference 2018
(Venice, Itália)
2017/08 Nitric Oxide Reductase Based-Biosensor Modified with Liposomes and Gold Nanoparticles for Nitric Oxide Detection 68th Annual Meeting of the International Society of Electrochemistry
(Estados Unidos)
2017/07 Anti-transferrin receptor antibody conjugated PLGA nanoparticles for temozolomide delivery 19th International Union of Pure and Applied Biophysics (IUPAB) and 11th European Biophysical Societies' Association (EBSA) Congress
(Edimburgo, Reino Unido)
2017/06 Liposomes for temozolomide delivery 2nd Doctoral Congress of Engineering (DCE17)
(Porto, Portugal)
2015/07 PLGA nanoparticles for Vitamin D3 deliver to human cancer cells 6th Iberian Meeting on Colloids and Interfaces (RICI6)
(Guimarães, Portugal)
2015/02 PLGA nanoparticles for calcitriol delivery 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG)
IEEE (Porto, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/02 - Atual Nanoparticles for the treatment of glioblastoma multiforme
Coorientador de Mariana Gomes
Master in Chemical Engineering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2023/02 - Atual Nanoparticles for glioblastoma therapy: an approach to increase therapeutic efficacy
Coorientador de Carina Nóbrega
Master in Biomedical Engineering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2023/02 - Atual Engineered nanoparticles for brain tumor therapy
Coorientador de Maria Manuel Teixeira
Master in Bioengineering (Iniciação científica)
Universidade do Porto Faculdade de Engenharia, Portugal
2022/03/02 - Atual Smart nanoparticles: an approach to fight brain cancer
Coorientador de Érica Serra
Master in Biomedical Engineering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2022/03/02 - Atual Tumor-targeting engineered nanoparticles for antioxidant therapy
Coorientador de Bruna Alves
Master in Biomedical Engineering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2021/02 - 2022/07 Tumor-targeting functional nanoparticles for cancer therapy
Coorientador de Inês Torres
Master in Biomedical Engineering (Mestrado)
Faculty of Engineering of University of Porto, Portugal
2021/02/01 - 2021/07/31 Biodegradable nanoparticles: a strategy to fight cancer
Coorientador de Margarida Costa
Integrade master in Chemical Engineering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2020/09 - 2021/07/30 Bioengineered nanoparticles for ligand-based dual targeted delivery in glioblastoma multiforme therapy
Coorientador de Maria Bravo
Integrated Master in Bioengineering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2020/09 - 2021/01 Nanoparticles for targeted drug delivery in glioblastoma multiforme therapy
Coorientador de Maria Bravo
Intergrated Master in Bioengineering (Iniciação científica)
Faculty of Engineering of University of Porto, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2017 - Atual Junior University of University of Porto. Member of the nanotechnology team. Among my responsabilities are: developing experimental protocols, teaching and supervising different laboratory activities to high school students (2017 - 2027)
Outro (Outra)
Faculty of Engineering of University of Porto, Portugal
2023/02/11 - 2023/02/11 Workshop "Nanoparticle Production and Characterization for Biomedical Applications https://www.adconferences.com/ (2023/02/10 - 2023/02/11)
Oficina (workshop) (Coorganizador)
Faculty of Engineering of University of Porto, Portugal
2023/02/10 - 2023/02/11 2nd symposium on Alzheimer Disease: an update on pathology and therapeutics". (please see website: https://www.adconferences.com/) (2023/02/10 - 2023/02/11)
Conferência (Coorganizador)
Faculty of Engineering of University of Porto, Portugal
2021/02/16 - 2021/02/17 1st symposium on Alzheimer Disease: an update on pathology and therapeutics". (please see website: https://ad1stminisymposium.wixsite.com/2021 ) (2021/02/16 - 2021/02/17)
Simpósio (Coorganizador)
Faculty of Engineering of University of Porto, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2022/04 - 2022/04 Representative of LEPABE/ALICE exhibition stand
Exposição
UP Annual Fair (Mostra U.Porto) (Science, Teaching and Innovation Display at the University of Porto)
2019/11/15 - 2019/11/15 Representative of the "Supramolecular assemblies" group at the LEPABE exhibition stand
Conferência
XV Jornadas de Engenharia Química - Chemical engineering around the world
Faculty of Engineering of University of Porto, Portugal
2019 - 2019 I attended the summer School on"In vivo gene delivery"
Outro
Summer Scholl on "In vivo gene delivery"
Universiteit Gent, Bélgica
2016 - 2019 Lectures and demonstration of experimental prodecures about nanotech to gradute students
Outro
Research That Matters - 2016 and 2019 Editions
Faculty of Engineering of University of Porto, Portugal
2015 - 2018 Presentation of the laboratory and brief lecture about nanotechnology to high school students
Outro
Engineer Profession Week - 2015 and 2018 editions
Faculty of Engineering of University of Porto, Portugal
2015/03/12 - 2015/03/15 Supervisor of the Bioengeneering course exhibition stand
Exposição
UP Annual Fair (Mostra U.Porto) (Science, Teaching and Innovation Display at the University of Porto)
University of Porto, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2023/02/10 - 2023/02/11 Co-organizer of the 2nd symposium on Alzheimer Disease: an update on pathology and therapeutics. please see website: https://www.adconferences.com/ Faculty of Engineering of UPorto
2021/02/16 - 2021/02/17 Co-organizer and Chair of the 1st symposium on Alzheimer Disease: an update on pathology and therapeutics. please see website: https://ad1stminisymposium.wixsite.com/2021 Faculty of Engineering of UPorto

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2022/02/01 - Atual Colloids and Interfaces (2504-5377) MDPI AG
2021/11 - Atual Polymers- I am a Topic Editor of this journal (2073-4360) MDPI
2021/09 - Atual Pharmaceutics - I am a member of the Topical Advisory Panel of this journal (1999-4923) MDPI
2020/12 - Atual Polymers (member of the Reviewers Board) (2073-4360) MDPI
2020/11 - Atual Pharmaceutics - I am a Topic Editor of this journal (1999-4923) MDPI
2020 - Atual Molecules (1420-3049) MDPI AG
2020 - Atual International Journal of Molecular Sciences (1422-0067) MDPI AG
2019 - Atual Brazilian Journal of Pharmaceutical Sciences (1984-8250) SciELO
2019 - Atual MOJ Drug Design Development & Therapy (2575-9094) MedCrave Group
2019 - Atual International Journal of Nanomedicine (1178-2013) Dove Medical Press
2019 - Atual Pharmaceuticals (member of the Reviewers Board) (1424-8247) MDPI AG

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022 - Atual Support in the characterization of nanomaterials produced within the Curricular Unit “Introduction to Nanotechnology” Master Degree in Chemical Engineering (Mestrado) Faculty of Engineering of University of Porto, Portugal
2021/10 - Atual Invited lecturer in the session ¿PLGA nanoparticles for brain tumour therapy¿, included in the Curricular Unit ¿Introduction to Nanotechnology¿ Integrated Master Degree in Chemical Engineering (Mestrado integrado) Faculty of Engineering of University of Porto, Portugal
2021/02 - Atual Student supervisor in the the Curricular Unit “Project and Laboratory Techniques” Master in Biomedical Engineering (Mestrado) Faculty of Engineering of University of Porto, Portugal
2020/09 - Atual Student supervisor in the the Curricular Unit “Seminars and Research Project” Integrated Master in Bioengineering (Mestrado integrado)
2020/11 - 2020/11 Invited lecturer in the session “PLGA nanoparticles for brain tumour therapy”, included in the Curricular Unit “Nano Materials/Systems/Manufacturing” Integrated Master in Chemical Engineering (Mestrado integrado) Faculty of Engineering of University of Porto, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2021/08/06 Article in Expresso Journal about Nevada project Expresso
2020/06/01 Acknowledgment in Maratona da Saúde Association website about my PhD supervisor being awarded with a 20,000 € prize for my PhD work Maratona da Saúde website
2018/06/13 Article in the ASPIC website: LEPABE (UPorto) researchers developed a nanosystem for glioblastoma multiforme therapy ASPIC website: https://www.aspic.pt/en/noticias/lepabe-uporto-researchers-developed-nanosystem-glioblastoma-multiform-therapy
2015/10/30 Article in ASPIC website with title: UPorto researchers developed an anti-tumor therapy nanossytem ASPIC website: https://www.aspic.pt/en/noticias/uporto-researchers-developed-anti-tumor-therapy-nanossytem

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2022/07 - 2022/07 Selection Jury for a Postdoctoral Research Fellowship under the research project Nanotechnology-based device for glioblastoma therapy Faculty of Engineering of University of Porto, Portugal
2022/05 - 2022/05 Selection Jury for Trainee Researcher contract under the research project EXPL/NAN-MAT/0209/2021 – NanoSAURUS - Nanotech-double functionalized particles to transport Nucleic Acid Mimics against Staphylococcus Aureus Faculty of Engineering of University of Porto, Portugal
Distinções

Prémio

2020 Maratona da Saúde Prize - Cancer Research - 2019 edition (https://www.fct.pt/apoios/premios/maratonadasaude/)
Associação Maratona da Saúde, Portugal