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I completed my PhD in June 2015 with distinction from the University of Porto, conducting research in the Cancer Genetics group at IPATIMUP and collaborating with Prof. Achim Leutz’s group at the Max Delbrück Center for Molecular Medicine in Berlin. Alongside, I obtained FELASA (Category C) certification, qualifying me to direct laboratory animal experimentation. I was awarded a postdoctoral fellowship (August 2015) and joined the Genetic Dynamics of Cancer Cells group at i3S under an FCT-funded project (PTDC/BIMMEC/2834/2014). This marked a pivotal transition, allowing me to investigate tumor evasion from immunosurveillance and develop expertise in cancer immunology. In January 2019, I advanced to Junior Researcher in the Intercellular Communication and Cancer group at i3S, contributing to another FCT-funded project (PTDC/MEC-ONC/32018/2017) that explored innovative approaches in cancer biology. In 2021, I became Principal Investigator (PI) of an FCT-funded project (EXPL/MED-ONC/1592/2021), focusing on optimizing immunotherapy by targeting glycosylation-mediated immune evasion. Recently, I secured a second FCT grant as PI (2023.14297.PEX) to develop strategies enhancing immune recognition of tumor-specific neoantigens, supported by advanced mouse models and promising preliminary data. This project also supports my first PhD student. Throughout my career, I have advanced understanding of the interplay between chronic inflammation and gastric cancer risk, uncovering novel transcription factor roles in gastric cancer cell survival. Additionally, I developed innovative mouse models of intestinal tumorigenesis, revealing glycosylation's role in immune evasion. Notably, our findings demonstrated that knocking out a cancer-associated glycosyltransferase, Mgat5, reduces tumor size and incidence by enhancing immune recognition. Published in Cancer Immunology Research and presented at international conferences, these discoveries underscore glycosylation's potential as a therapeutic target. Collaboration has been central to my research. Internationally, I have worked with Prof. Andrés Ruiz-Linares (University College London), Prof. Achim Leutz (Berlin), and recently initiated partnerships with Prof. Bauke Ylstra (Amsterdam) and Prof. Michael MacManus (UCSF). Nationally, I collaborate with Profs. Salomé Pinho, Bruno Sarmento, Elsa Logarinho, Alexandra Moreira and Celso Reis at i3S. These efforts have yielded impactful publications and preliminary data poised for publication in 2025. I have mentored 5 Master’s students and currently supervise one PhD candidate while serving on another's advisory committee. Additionally, I have trained 2 hematologists and 12 undergraduate students. Since 2021, I have lectured in the Oncology Master’s program at ICBAS-IPO, evaluated research projects, and served as an external evaluator for the Liga Portuguesa Contra o Cancro. I also actively disseminate science through outreach programs like Ciência Viva, Universidade Júnior, and Mostra UP. My scientific background, leadership skills, and dedication position me to make meaningful contributions to cancer immunology, bridging research and clinical translation for societal benefit. I am driven to explore innovative solutions in immune recognition and tumor biology, fostering progress in this vital field.
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Identificação

Identificação pessoal

Nome completo
Carlos Resende

Nomes de citação

  • Resende, Carlos

Identificadores de autor

Ciência ID
CE11-E4E5-8056
ORCID iD
0000-0001-7143-7099

Endereços de correio eletrónico

  • cresende@ipatimup.pt (Profissional)

Moradas

  • i3s/ IPATIMUP. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Patologia
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2010 - 2015/06/16
Concluído
 Doctoral Program in Pathology and Molecular Genetics (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"The role of CREB and C/EBP transcription factors in gastric carcinogenesis" (TESE/DISSERTAÇÃO)
 Approved with Distinction
2001/09 - 2005/09
Concluído
 Biologia-Ramo Científico (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Genetic screening of critical effectors of interleukin-6 signalling pathway" (TESE/DISSERTAÇÃO)
 17 (0 to 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/08/01 - 2025/12/31 Investigador Contratado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09/01 - 2023/06/28 Investigador Contratado (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2019/01/01 - 2021/07/31 Investigador (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/09/15 - 2018/12/31 Pós-doutorado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2010/01/01 - 2015/06/16 PhD student developing the work in Cancer Genetics Group Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2008/01/01 - 2009/12/31 Technician at IPATIMUP Diagnostics Unit Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005/09/01 - 2007/12/31 BIC fellow - Initiation research fellowship at Cancer Genetics Group Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005/02/15 - 2005/07/31 Undergraduate student Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projetos

Bolsa

Designação Financiadores
2025/01/02 - 2026/06/30 Unveiling the Role of Neoantigens in Cancer: From Mechanisms to Immunotherapy Strategies
2023.14297.PEX
Investigador responsável
Fundação para a Ciência e a Tecnologia
2022/01/01 - 2023/06/30 Glycosylation and cancer: immunosurveillance’s sweet spot - GlyCan
EXPL/MED-ONC/1592/2021
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2015/03 - 2021/07 Chemotherapy effect on Kinetics of regulatory T cells in Acute Myeloid Leukemia and high risk Myelodysplastic Syndromes
Celgene GRANT-POR- 049
Investigador
Concluído
2017/11 - 2019/11 The role of T lymphocyke differentiation in IBD - Associated colorectal carcinoma
CROHNJCM
Investigador responsável
Grupo de Estudo da Doença Inflamatória Intestinal
Concluído
2016/01 - 2018/12 The yin and yang of somatic mutations in cancer immunosurveillance
PTDC/BIM-MEC/2834/2014
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2012/09 - 2014/08 Identification of genetic markers for prediction of the clinical course and development of complications in Portuguese Crohn's Disease patients
CROHN3
Bolseiro de Investigação
Grupo de Estudo da Doença Inflamatória Intestinal
Concluído
2009/01 - 2012/12 The Role of C/EBPbeta and CREB transcription factors in gastric carcinogenesis
SFRH/BD/46504/2008
Bolseiro de Doutoramento
Concluído

Projeto

Designação Financiadores
2019/01 - 2021/07 Neoantigen signature algorithm to predict immunotherapy response
PTDC/MEC-ONC/32018/2017
Bolseiro de Integração na Investigação
Fundação para a Ciência e a Tecnologia
Em curso
2017/10/16 - 2020/01/16 Tiras de teste para rastreio de biomarcadores de tromboembolismo venoso em oncologia
SAICT-POL/24358/2016
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/09/01 - 2019/09/30 O papel dos Tregs na resposta imune ao cancro
PTDC/MED-PAT/32462/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/02/01 - 2019/07/31 O yin e o yang das mutações somáticas na imunovigilância do cancro
PTDC/BIM-MEC/2834/2014
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2019/01 - 2021/07 Tregs in cancer immune response
PTDC/MED-PAT/32462/2017
Outra
Fundação para a Ciência e a Tecnologia
Em curso
2016/05 - 2019/12 Detection of tumor biomarkers using circulating tumor cell-free nucleid acids/exosomes as a source for biomarkers of intra-tumor heterogenetity
CANCERL5WP1/2
Bolseiro de Investigação
Concluído
2013/03 - 2016/02 Determing the CCAAT/enhancer binding protein ß (C/EBPß) partnership profile in gastric carcinogenesis
JCMP2
Bolseiro de Investigação
Concluído
Produções

Publicações

Artigo em conferência
  1. Durães C, Canedo P, Resende C, Figueiredo C & Machado JC. "Genetic variation in inflammation-related genes and risk of gastric carcinoma". Trabalho apresentado em Sociedade Portuguesa de Genética Humana, 2007.
    Publicado
  2. Regalo, G; Resende, Carlos; Wen, X; Suriano, G; Oliveira, Maria; Figueiredo, Ceu; Seruca, Raquel; Carneiro, Fatima; Machado, José Carlos. "C/EBPalpha is down-regulated in gastric carcinogenesis and is associated with decreased proliferation of gastric carcinoma cells". Trabalho apresentado em XX International Workshop of the European Helicobacter Study Group, Istanbul, 2007.
    Publicado
Artigo em revista
  1. Oliveira Rocha, Betina; Resende, Carlos; Xavier-Ferreira, Helena; Vilarinho, Ana; Cavadas, Bruno; Gullo, Irene. "Msh2 and Apc mutated mouse models closely mimic the differences between Hereditary Nonpolyposis Colorectal Cancer and Familial Adenomatous Polyposis". Microbiota in Health and Disease 5 e:826 (2023):
    Publicado
  2. Almeida, Andreia; Castro, Flávia; Resende, Carlos; Lúcio, Marlene; Schwartz, Simó; Sarmento, Bruno. "Oral delivery of camptothecin-loaded multifunctional chitosan-based micelles is effective in reduce colorectal cancer". Journal of Controlled Release 349 (2022): 731-743. http://dx.doi.org/10.1016/j.jconrel.2022.07.029.
    Acesso aberto • Publicado • 10.1016/j.jconrel.2022.07.029
  3. Freitas, João Augusto; Gullo, Irene; Garcia, Diogo; Miranda, Sara; Spaans, Louisa; Pinho, Lídia; Reis, Joana; et al. "The Adaptive Immune Landscape of the Colorectal Adenoma-Carcinoma Sequence". International Journal of Molecular Sciences 22 18 (2021): 9791. http://dx.doi.org/10.3390/ijms22189791.
    Publicado • 10.3390/ijms22189791
  4. Resende, Carlos; Gomes, CP; Machado, JC. "Gastric cancer: Basic aspects.". Helicobacter (2020):
    Publicado
  5. Silva, Mariana C.; Fernandes, Ângela; Oliveira, Maria; Resende, Carlos; Correia, Alexandra; de-Freitas-Junior, Julio C.; Lavelle, Aonghus; et al. "Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression". Cancer Immunology Research 8 11 (2020): 1407-1425. http://dx.doi.org/10.1158/2326-6066.cir-20-0264.
    Publicado • 10.1158/2326-6066.cir-20-0264
  6. Chacón-Duque, J.-C.; Adhikari, K.; Fuentes-Guajardo, M.; Mendoza-Revilla, J.; Acuña-Alonzo, V.; Barquera, R.; Quinto-Sánchez, M.; et al. "Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance". Nature Communications 9 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85058883000&partnerID=MN8TOARS.
    10.1038/s41467-018-07748-z
  7. Regalo G, Förster S, Resende C, Bauer B, Fleige B, Kemmner W, Schlag PM, Meyer TF, Machado JC, Leutz A. "C/EBPß regulates homeostatic and oncogenic gastric cell proliferation". Journal of Molecular Medicine (Berlin) (2016):
    10.1007/s00109-016-1447-7
  8. Resende, C.; Regalo, G.; Durães, C.; Pinto, M.T.; Wen, X.; Figueiredo, C.; Carneiro, F.; Machado, J.C.. "Interleukin-1B signalling leads to increased survival of gastric carcinoma cells through a CREB-C/EBPß-associated mechanism". Gastric Cancer 19 1 (2016): 74-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951569926&partnerID=MN8TOARS.
    10.1007/s10120-014-0448-x
  9. Pereira C, Veiga N, Resende C, Amaral MO, Pereira J. "Prevalence and determinants of oral microflora among portuguese adolescents". Atention Primaria 48 (2016): 234-239.
    Publicado
  10. Veiga, N.; Pereira, C.; Resende, C.; Amaral, O.; Ferreira, M.; Nelas, P.; Chaves, C.; et al. "Oral and gastric helicobacter pylori: Effects and associations". PLoS ONE 10 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84959278408&partnerID=MN8TOARS.
    10.1371/journal.pone.0126923
  11. Albergaria, A.; Resende, C.; Nobre, A.R.; Ribeiro, A.S.; Sousa, B.; Machado, J.C.; Seruca, R.; Paredes, J.; Schmitt, F.. "CCAAT/Enhancer Binding Protein ß (C/EBPß) Isoforms as Transcriptional Regulators of the Pro-Invasive CDH3/P-Cadherin Gene in Human Breast Cancer Cells". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873547668&partnerID=MN8TOARS.
    10.1371/journal.pone.0055749
  12. Resende, C.; Thiel, A.; Machado, J.C.; Ristimäki, A.. "Gastric Cancer: Basic Aspects". Helicobacter 16 SUPPL. 1 (2011): 38-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052554359&partnerID=MN8TOARS.
    10.1111/j.1523-5378.2011.00879.x
  13. Resende, C.; Ristimäki, A.; Machado, J.C.. "Genetic and Epigenetic Alteration in Gastric Carcinogenesis". Helicobacter 15 SUPPL. 1 (2010): 34-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-78249282604&partnerID=MN8TOARS.
    10.1111/j.1523-5378.2010.00782.x
  14. Regalo, G.; Resende, C.; Wen, X.; Gomes, B.; Dures, C.; Seruca, R.; Carneiro, F.; MacHado, J.C.. "C/EBPa expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis". Laboratory Investigation 90 8 (2010): 1132-1139. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955147186&partnerID=MN8TOARS.
    10.1038/labinvest.2010.79
  15. Resende, Carlos; Regalo, Gonçalo; Durães, Cecília; Carneiro, Fátima; Machado, José C.. "Genetic Changes of CEBPA in Cancer: Mutations or Polymorphisms?". Journal of Clinical Oncology 25 17 (2007): 2493-2494. http://dx.doi.org/10.1200/jco.2007.10.7227.
    Publicado • 10.1200/jco.2007.10.7227
  16. Resende, C.; Regalo, G.; Durães, C.; Carneiro, F.; Machado, J.C.. "Genetic changes of CEBPA in cancer: Mutations or polymorphisms? [6]". Journal of Clinical Oncology 25 17 (2007): 2493-2494. http://www.scopus.com/inward/record.url?eid=2-s2.0-34347253936&partnerID=MN8TOARS.
    10.1200/JCO.2007.10.7227
  17. Regalo, G.; Canedo, P.; Suriano, G.; Resende, C.; Campos, M.L.; Oliveira, M.J.; Figueiredo, C.; et al. "C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression". Journal of Pathology 210 4 (2006): 398-404. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751521001&partnerID=MN8TOARS.
    10.1002/path.2063
Poster em conferência
  1. Fernandes, Ângela; C Silva, Mariana; Resende, Carlos; Correia, Alexandra; Henrique, Rui M; Dinis-Ribeiro, Mário; Marcos-Pinto, Ricardo; Machado, José Carlos; Pinho, Salomé S. "The glyco-code in colorectal cancer immunoediting: glycans as novel immune checkpoints". Trabalho apresentado em XXIX Porto Cancer Meeting, 2023.
  2. Resende, Carlos; Xavier-Ferreira, Helena; Vilarinho, Ana; Gomes, Joana; Rodrigues, Joana; Cavadas, Bruno; Reis, Celso; Machado, José Carlos. "New evidences linking immunity, tumor development and tumor-associated glycosylation in a preclinical model of intestinal tumorigenesis". Trabalho apresentado em XXIX Porto Cancer Meeting, 2023.
  3. Vilarinho, Ana; Resende, Carlos; Xavier-Ferreira, Helena; Cavadas, Bruno; Machado, José Carlos. "THE INTERPLAY BETWEEN SOMATIC MUTATIONS AND CANCER IMMUNOSURVEILLANCE: A MOUSE STORY". Trabalho apresentado em 4th SPLC-CRS Young Scientists Meeting, 2023.
  4. Pereira-Castro, Isabel; de Mendonça, FL; Ferreira, A; Ferreira, PG; Resende, Carlos; Machado, JC; Moreira, A. "The function of the immune system in colorectal cancer alternative polyadenylation". Trabalho apresentado em EMBL Symposium The complex life of RNA, Heidelberg, 2022.
  5. Machado, AL; Martins, F; Mendonça, S; Ribeiro, A; Dias Carvalho, P; Araújo, J; Fonseca, E; et al. "Mutant KRAS elicits an intestinal-spleen immunoregulatory crosstalk during intestinal tumorigenesis". Trabalho apresentado em 4th Symposium on Immunomodulation in Cancer & Regeneration, 2022.
  6. Silva, Mariana C.; Fernandes, Ângela; Oliveira, Maria; Resende, Carlos; Correia, Alexandra; de-Freitas-Junior, Julio C.; Xavier-Ferreira, Helena; et al. "Glycans as immune checkpoints: removal of branched N-glycans enhances anti-tumor immune response". Trabalho apresentado em 27th Porto Cancer Meeting ¿ Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  7. Resende, Carlos; Gomes, Joana; Rodrigues, Joana; Costa, José Luís; Reis, Celso; Machado, José Carlos. "Immunity and tumor development: new evidences from preclinical models". Trabalho apresentado em EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment in Lisbon, Portugal from 02 to 04 March 2020, 2020.
  8. Silva, Mariana C.; Fernandes, Ângela; Oliveira, Maria; Resende, Carlos; Correia, Alexandra; Pereira, Carina; Marcos-Pinto, Ricardo; et al. "The Glyco-code in colorectal cancer immunoediting: mechanisms and immunotherapeutic applications.". Trabalho apresentado em EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment, 2020.
  9. .A. Freitas, H. Xavier-Ferreira, C. Resende, J. Pereira Reis, J.L. Costa, C. Pereira Gomes, J.C. Machado. "The origin of tumour-infiltrating regulatory T cells". Trabalho apresentado em 8th i3S Annual Meeting, 2019.
  10. M.C. Silva, Â. Fernandes, A. Correia, C. Resende, J.C.M. de-Freitas-Junior, H. Ferreira, N. Mendes, C. Pereira; R. Henrique, M. Leander, M. Lima, R. Marcos-Pinto, J.C. Machado, M. Vilanova, S.S. Pinho. "Glycosylation in Gastrointestinal Cancer Immunosurveillance". Trabalho apresentado em 8th i3S Annual Meeting, 2019.
  11. Brandão S, Resende C, Miranda S, Xavier-Ferreira H, Freitas J, Carneiro F, Magro F, Machado JC. "T cell polarization influences the development of IBD-associated neoplasia". Trabalho apresentado em 12th IJUP, 2019.
  12. Xavier-Ferreira H, Resende C , De Miranda NF, Machado JC. "Role of Intratumor Heterogeneity in Cancer Immunosurveillance". Trabalho apresentado em 7th i3S Annual Meeting, 2018.
  13. Miranda S, Spaans L, Garcia D, Xavier-Ferreira H, Freitas JA, Resende C, Brandão A, Carneiro F, Machado JC. "The genetic and immune context in colorectal adenoma development". Trabalho apresentado em 7th i3S Annual Meeting, 2018.
  14. Fernandes Â, Silva MC, Correia A, Resende C, de-Freitas-Junior JCM, Xavier-Ferreira H, Mendes N; Pereira C, Henrique R, Leander M, Lima M, Marcos-Pinto R, Machado JC, Vilanova M, Pinho SS. "Glycosylation in Intestinal Cancer Immunosurveillance". Trabalho apresentado em 7th i3S Annual Meeting, 2018.
  15. Brandão S, Resende C, Carneiro F, Miranda S, Ferreira H, Machado JC. "T cell polarization influences the development of IBD-associated neoplasia". Trabalho apresentado em 7th i3S Annual Meeting, 2018.
  16. da Silva S, Ruivo CF, Adem B, Bastos N, Melo CA, Resende C, Zeisberg M, Wu P, Sugimoto H, Bayon GF, Fernandez AF; Machado JC, Kalluri R, Melo SA. "Cancer Exosomes Modify the Methylation Landscape of Tumor Associated Fibroblasts through HiC2". Trabalho apresentado em 6th i3S Annual Meeting, 2017.
  17. Resende C, Ferreira H, Resende A, Durães C, Costa JL, Machado JC. "Preclinical findings on cancer immunosurveillance and somatic mutation load in intestinal tumorigenesis". Trabalho apresentado em XXIV Porto Cancer Meeting, 2016.
  18. Ferreira H, Resende C, de Miranda NF, Machado JC. "Role of genetic heterogeneity in cancer immunosurveillance". Trabalho apresentado em XXIV Porto Cancer Meeting, 2016.
  19. Resende C, Ferreira H, Durães C, Costa JL, Machado JC. "Somatic mutations and immunosurveillance: a mouse story". Trabalho apresentado em i3S Annual Meeting, 2015.
  20. Silva, Miguel; Resende, Carlos; Barranha, Rui; Justino, Ana; Meireles, Sara; Carneiro, Fatima; Machado, José Carlos; Costa, José Luís. "Colorectal intratumoral genetic heterogeneity: a pilot study". Trabalho apresentado em XXIII Porto Cancer Meeting - Stem Cells and Cancer, 2015.
  21. Durães C, Canedo P, Resende C, Figueiredo C, Machado JC. "Genetic variation in inflammation-related genes and risk of gastric carcinoma". Trabalho apresentado em Sociedade Portuguesa de Genética Humana, 2007.
Resumo em conferência
  1. Silva, Mariana C.; Fernandes, Ângela; Oliveira, Maria; Resende, Carlos; Correia, Alexandra; de-Freitas-Junior, Julio C.; Xavier-Ferreira, Helena; et al. "Glycans as immune checkpoints: removal of branched N-glycans enhances immune recognition preventing cancer progression". Trabalho apresentado em 2020 Annual Meeting of the Society for Glycobiology, published in Glycobiology, 2020.
    Publicado • 10.1093/glycob/cwaa094
  2. Silva, Miguel; Resende, Carlos; Barranha, Rui; Meireles, Sara; Carneiro, Fatima; Costa, Jose L.; Machado, Jose C.. "Colorectal primary tumors and metastases are highly homogeneous regarding driver mutations". 2016.
    10.1158/1538-7445.AM2016-2398
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/11/17 The immune system shapes the tumor genetic landscape skewing against putative immunogenic mutations. 10th i3S Annual Meeting
(Póvoa do Varzim, Portugal)
2023/05/12 New evidences linking immunity, tumor development and tumor-associated glycosylation in a preclinical model of intestinal tumorigenesis. XXIX Porto Cancer Meeting
i3S (Porto, Portugal)
2018/04/19 Assessing clonal composition and evolution underlying relapse in acute myeloid leukemia: a patient derived xenograft mouse model story Spring Meeting of the EORTC LEUKEMIA GROUP
(Porto, Portugal)
2017/11/09 Interplay between tumor genetics and immunosurveillance 6th i3S Annual Meeting
i3S (Vila de Conde, Portugal)
2017/11/09 Role of intra-tumor heterogeneity in cancer immunosurveillance. 6th i3S Annual Meeting
(Póvoa do Varzim, Portugal)
2014/09/11 IL1B signaling leads to increased cell survival of gastric carcinoma cells XXVII International Workshop on Helicobacter & Microbiota in Inflammation & Cancer.
(Rome, Itália)
2010/09/16 Determining the CCAAT/enhancer binding protein B (C/EBPB) partnership profile in gastric carcinogenesis XXIII International Worshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer
(Roterdão, Países Baixos)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/01/01 - 2027/12/31 Cancer immunoevasion: mechanistic basis and therapeutic strategies
Coorientador
Universidade do Porto Faculdade de Medicina, Portugal
2024/02/01 - 2024/06/30 The role of immunosurveillance in colorectal cancer
Orientador
Universitat de Barcelona Facultat de Biologia, Espanha
2019/10/01 - 2023/11/23 Assessing the cellular and molecular dynamics underlying disease progression in acute myeloid leukemia
Coorientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/11/03 - 2023/06/30 Is FoxM1 a friend or foe in murine intestinal tumorigenesis?
Orientador
 Laboratory internship included in the Biology Course (Iniciação científica)
Universidade do Porto Faculdade de Ciências, Portugal
2022/11/02 - 2023/06/30 The role of immunosurveillance in colon cancer
Coorientador
 Laboratory internship included in the Biology Course (Iniciação científica)
Universidade do Porto Faculdade de Ciências, Portugal
2023/02/17 - 2023/06/15 New genetic evidences of cancer immunosurveillance in a murine model of MSI intestinal tumorigenesis
Coorientador
 Laboratory internship included in the Bioengineering Course (Iniciação científica)
Universidade do Porto Faculdade de Engenharia, Portugal
2020/09/01 - 2022/12/31 The role of tumor infiltrating lymphocytes and escape to cancer immunosurveillance
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2022/09/01 - 2022/12/20 Effect of immunosurveillance on tumor growth
Coorientador
2021/09/01 - 2022/12/06 THE INTERPLAY BETWEEN SOMATIC MUTATIONS AND CANCER IMMUNOSURVEILLANCE: A MOUSE STORY
Coorientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - 2020 Castration-resistant prostate cancer development: the potential role of alternative signaling pathways
Coorientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2019 T cell polarization influences the development of IBD-associated neoplasia
Coorientador
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2025/07/23 Identification of biomarkers of glycosylation in gastrointestinal cancer
Arguente
 Rúben Bento da Silva (Outro)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/11/25 Thyroid Microenvironment Deconvolution – A Comparative Analysis with SingleCell Reference Input in Cancer
Arguente principal
 Guilherme Vale Puga (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2023/12/11 MicroRNA profile associated with enzalutamide resistance in Prostate Cancer: an opportunity for biomarker and therapeutic target identification.
Arguente principal
 Inês Maria Amorim Tavares (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/07/11 Intercellular communication and Resistance to Targeted Therapy in Cancer
Arguente principal
 Carolina de Almeida Peixoto (Outro)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/05/18 Particularities of the Hedgehog pathway in acute myeloid leukemia and the role of primary cilia in sensitivity to SMO inhibitors
Arguente principal
 Inês Silva Moreira (Mestrado)
2020/07/29 Intratumor heterogeneity and its impact on immunotherapy
Arguente principal
 Ana Isabel Vilarinho da Costa e Silva (Outro)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/12 Impact of the aberrant expression of branched N-glycans in Colorectal Cancer Immunoediting
Arguente principal
 Maria Adelaide Marçal Oliveira (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/11/21 - 2023/11/21 Módulo de Modelos de Cancerização Experimental, integrado no Mestrado em Oncologia (IPO/ICBAS) (Curso de mestrado (conclusão do curso de especialização)) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/11/24 - 2022/11/24 Módulo de Modelos de Cancerização Experimental, integrado no Mestrado em Oncologia (IPO/ICBAS) (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/01/07 - 2021/01/07 Formação avançada pós-universitária em Oncologia, Liga Portuguesa Contra o Cancro - NRN (Pós-Graduação)

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2022/09/24 - 2022/09/24 Jury of oral communications in the 4º Encontro Nacional de Jovens Investigadores em Oncologia at Liga Portuguesa Contra o Cancro Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal

Tutoria

Tópico Nome do aluno
2022/07/15 - 2022/10/28 Supervised Laboratory Animal Science Training - as part of the Introductory Course in Laboratory Animal Science (function A + D) ANA ISABEL VILARINHO DA COSTA E SILVA
2021/05/01 - 2021/05/31 Laboratory and animal science internship integrated in Biomedical Doctoral Program from FMUP Patrícia Vieira
2019/01 - 2019/06 Training and supervising in vivo experiments in mice João Augusto Freire
2018/10 - 2019/01 Laboratory training incorporated in the internship in Hematology Pedro Medeiros
2018/01 - 2018/06 Training and supervising in vivo experiments in mice Ana Sofia Brandão
2017/10 - 2018/01 Laboratory training incorporated in the internship in Hematology Gil Brás
2017/05 - 2017/10 Laboratory internship integrated in Medical Master's degree from Maastricht University Louisa Spaans
Distinções

Outra distinção

2016 Best scientific article CI&DETS
2014 Best Oral Presentation
2005 Award Engº António de Almeida
2004 Award Doctor Manuel Ferreira