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Jens Wiltfang is the Director of the Clinic of Psychiatry and Psychotherapy and Full Professor at the University Medical Center Göttingen, and Invited Full Professor at University of Aveiro (Catedra Ilídio Pinho). JW published 584 articles in journals (h-index=76; 21015 citations) and has 7 patents registered. Has received 6 awards and/or honors. JW research group focuses on blood biomarker-guided early and predictive diagnosis of neurodegenerative diseases which will allow to identify high-risk patients and to offer novel preventive therapies. This approach is of high clinical relevance to come up with novel clinical models of sporadic (multi-genetic) neurodegenerative dementias, most importantly Alzheimers Disease (AD), and to develop first disease modifying (preventive) pharmacological therapies. Indeed, the second focus of his research activities is to develop novel treatment options of Alzheimers Dementia. His current research has provided evidence for a novel alternative beta-secretase activity which endoproteolytically cleaves beta-amyloid precursor protein independent of beta-amyloid cleaving enzyme. These findings have become of clinical relevance and may constitute a novel therapeutic target.
Identificação

Identificação pessoal

Nome completo
Jens Wiltfang

Nomes de citação

  • Wiltfang, Jens

Identificadores de autor

Ciência ID
CC14-8DED-2DBF
ORCID iD
0000-0003-1492-5330

Endereços de correio eletrónico

  • jens.wiltfang@med.uni-goettingen.de (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Neurologia Clínica
  • Ciências Médicas e da Saúde - Medicina Clínica - Psiquiatria
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Alemão (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
1999 - 2002
Concluído
Senior resident (Oberarzt) (Título de especialista)
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2002
Concluído
Habilitation, venia legend for Psychiatry & Psychotherapy (Título de Agregado)
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
1988
Concluído
Graduation in medicine (Dr. med., magna cum laude) (Doutoramento)
Medical Academy Hannover, Alemanha
1979 - 1986
Concluído
Study of Medicine (Licenciatura)
Medical Academy Hannover, Alemanha
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2013 - Atual Investigador principal (carreira) (Investigação) Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2007 - 2013 Investigador principal (carreira) (Investigação) LVR-Klinikum Essen Klinik für Psychiatrie und Psychotherapie, Alemanha
2002 - 2007 Investigador principal (carreira) (Investigação) Friedrich-Alexander-Universität Erlangen-Nürnberg, Alemanha
1987 - 1987 Investigador (Investigação) Max-Planck-Institut für experimentelle Medizin, Alemanha
Max-Planck-Institut für experimentelle Medizin, Alemanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2015 - Atual Professor Catedrático Convidado (Docente Universitário) Universidade de Aveiro, Portugal
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2013 - Atual Professor Catedrático (Docente Universitário) Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2007 - 2013 Professor Catedrático (Docente Universitário) Universität Duisburg-Essen, Alemanha
2002 - 2007 Professor Catedrático (Docente Universitário) Friedrich-Alexander-Universität Erlangen-Nürnberg, Alemanha

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2013/10 - Atual Head of clinical research Deutsches Zentrum für Neurodegenerative Erkrankungen, Alemanha
Deutsches Zentrum für Neurodegenerative Erkrankungen, Alemanha
2013 - Atual Chair for clinical psychiatry and psychotherapy Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2013 - Atual Clinical director of the Department of Psychiatry and Psychotherapy Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2013 - Atual Chair of the group for Neuropsychopharmacology and Pharmopsychiatry Association of Neuropsychopharmacology and Pharmacopsychiatry, Alemanha
2007 - 2013 Clinical director of the Department of Psychiatry and Psychotherapy Universität Duisburg-Essen, Alemanha
Projetos

Bolsa

Designação Financiadores
2012 - 2015 PEPMIP Robust affinity materials for applications in proteomics and diagnostics
264699
Investigador
Universität Duisburg-Essen, Alemanha
EU - Seventh Framework Programme; Marie Curie Initial Training Network
Concluído
2004 - 2005 Alternative pre-mRNA-splicing as pathological factors in Alzheimer´s Disease
04.03.12.1
Investigador responsável
ELAN - Study Exchange grant
Concluído
2003 - 2004 Identification of novel dementia biomarkers by SELDI-TOF-MS
02.10.18.1
Investigador responsável
ELAN - Study Exchange grant
Concluído
1998 - 2002 Analysis and Function of 14-3-3 Proteins
BMH4-CT98-6
Investigador
European Commission
Concluído

Projeto

Designação Financiadores
2021 - 2024 Automatisierter Beta-Amyloid Bluttest zur Frühdiagnostik der Alzheimerdemenz (Abeta-IP) / Automated beta-amyloid blood test for early diagnosis of Alzheimer's dementia (Abeta-IP)
13GW0479B
Investigador responsável
German Federal Ministry for Education and Research (BMBF)
Em curso
2020 - 2024 Principal Investigator at iBiMED
UIDB/04501/2020
UIDP/04501/2020
Investigador responsável
Fundação para a Ciência e a Tecnologia
2019/01 - 2023/10/31 Exosomes as Diagnostic Tools for Alzheimer´s disease - EXO_DIAG_AD
Co-Investigador Responsável (Co-IR)
Universidade de Aveiro Instituto de Biomedicina, Portugal
Alzheimer's Association
Concluído
2015 - 2020 Principal Investigator at iBiMED
PTCRIS: 147343
Investigador responsável
Universidade de Aveiro Instituto de Biomedicina, Portugal
Em curso
2016 - 2019 AD-Blood-Assay, Blood based early and predictive diagnostics of Alzheimers dementia
PTDC/DTP-PIC/5587/2014
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2014 - 2018 Funding for the research unit iBiMED
UID/BIM/04501/2013
Investigador
Universidade de Aveiro Instituto de Biomedicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/01 - 2015/12 Functional analyses of SH2B1 mutations with relevance for body weight regulation
Investigador
Deutsche Forschungsgemeinschaft
Concluído
2012 - 2015 Multidisciplinary Approach of new strategies applied to neuropathologies
MI-PI-43-ARH/2012
Investigador
Quadro de Referência Estratégico Nacional - QREN Centro
Concluído
2012 - 2015 JPND Initiative BIOMARKAPD - Biomarkers for Alzheimer's disease and Parkinson's disease
01ED1203A
Investigador
EU - Joint Programme Neurodegenerative Disease Research
Concluído
2012 - 2015 NeuroAllianz - Projekt D7: Blut-Assay für die prädiktive und Frühdiagnostik der Alzheimerdemenz / NeuroAllianz - Project D7: Blood assay for the predictive and early diagnosis of Alzheimer's dementia
Projekt D7: Blut-Assay für die prädiktive und Frühdiagnostik der Alzheimerdemenz
161A120B/ 031A120B
Investigador
German Federal Ministry for Education and Research (BMBF)
Concluído
2010 - 2015 NADINE - Nanosystems for early Diagnosis of Neurodegenerative Diseases
CP-IP 246513-2 NADINE
Investigador
EU - Seventh Framework Programme
Concluído
2009/01 - 2014/12 The effect of cognitive remediation on parameters of event-related potentials in schizophrenia
Investigador responsável
Deutsche Forschungsgemeinschaft
Concluído
2010 - 2014 IMI-PHARMACOG Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in early clinical development
115009
Investigador
IMI-EU - Seventh Framework Programme
Concluído
2009 - 2014 PURE Protein-research Unit Ruhr within Europe
PURE
Investigador
PURE - Ruhr-Universität Bochum, Alemanha
Nordrhein-Westfalen (federal funding)
Concluído
2011 - 2011 molFDAD - Entwicklung neuer Biomarkertests zur Unterstützung der molekularen Frühdiagnostik der Alzheimerdemenz / molFDAD - Development of new biomarker tests to support early molecular diagnosis of Alzheimer's dementia
005-1006-0052
Investigador
State government of North Rhine-Westphalia
Concluído
2008 - 2010 Clinical trial - Dementia project: Influence of multiple sport activities on daily tasks and cognition in early stages of Alzheimer´s dementia (Sport & Kog) - Leader of consortium
LT-Demenz-44-031
Investigador responsável
Bundesministerium für Gesundheit
Concluído
2008 - 2010 Clinical trial - Diabetes network: DECODIA - Part 1: Comparative study on the effect of intranasal insulin on memory functions in type 2 diabetes and early Alzheimer's dementia (INSULA) - Leader of consortium
01GI0817
Investigador responsável
German Federal Ministry for Education and Research (BMBF)
Concluído
2008 - 2010 Clinical trial - Randomized Controlled Trial of Simvastatin in Amnestic MCI Patients (SI-MaMCI) - Leader of consortium
2008-002226-11
Investigador
German Federal Ministry for Education and Research (BMBF)
Concluído
2007 - 2010 NeuroTAS - Microfluidic Total Analysis System For The Early Diagnostic Of Neurodegenerative Disorders
LSH-2005-1.2.2-2
Investigador
European Commission Sixth Framework Programme
Concluído
2007 - 2010 cNEUPRO - Clinical Neuroproteomics of Neurodegenerative Diseases
LSHM-CT-2007-037950
Investigador responsável
European Commission Sixth Framework Programme
Concluído
2007 - 2008 Establishment of a cell culture model to study the effects of psycopharmacompounds in Taupathies
MAROHN
Investigador
Friedrich-Alexander-Universität Erlangen-Nürnberg, Alemanha
Concluído
2004 - 2008 Clinical analysis of the neuroproteome in dementia: Identification of novel biomarkers for the early diagnosis and preventive therapy
01GR0447
Investigador responsável
German Federal Ministry for Education and Research (BMBF)
Concluído
2004 - 2007 Early and differential diagnosis of dementia; neurochemical dementia diagnostic - 2nd period funding
01GI0102
Investigador responsável
German Federal Ministry for Education and Research (BMBF)
Concluído
2005 - 2006 Molecular Neuroimaging of Dementias
ScheringAG
Investigador responsável
Concluído
2005 - 2006 APOPIS - Abnormal proteins in the pathogenesis of neurodegenerative disorders
503330
Investigador responsável
European Commission Sixth Framework Programme
Concluído
2005 - 2006 Effect of quetiapine on abeta peptide release by cultured chicken telen-cephalic neurons - comparison with haloperidol and clozapine
Astra Zeneca
Investigador responsável
AstraZeneca GmbH
Concluído
2004 - 2006 Establishment of H1-NMR-Spectroscopy for the pre-clinical diagnostic of Alzheimer´s disease mild cognitive impairment
Firma Altenbuchinger (Trust funding)
Investigador responsável
Concluído
2003 - 2006 Research network for improvement of differential and early diagnosis of Creutzfeldt-Jakob disease and the new variant of Creutzfeldt-Jakob disease
01GI0301
Investigador responsável
German Federal Ministry for Education and Research (BMBF)
Concluído
2002 - 2005 Early diagnosis of transmissible spongiform encephalopathies by proteomic analysis
TSE-Diagnostics
Investigador
German Federal Ministry for Education and Research (BMBF)
Concluído
2003 - 2004 Proteomic analysis in neurodegenerative disorders
CMPB
Investigador
DFG Research Center Molecular Physiology of the Brain
Concluído
2002 - 2004 Early and differential diagnosis of dementia; neurochemical dementia diagnostic
01GI0102
Investigador responsável
German Federal Ministry for Education and Research (BMBF)

Dementia Competence Network
Concluído
2001 - 2004 DIADEM - Early Diagnosis of Alzheimer´s disease and Related Dementias
QLK3-CT-2001-02362
Investigador responsável
European Commission
Concluído
2001 - 2001 Inhibition of enzymatic APP processing by synthetic secretase inhibitors in cultured chicken telencephalic neurons (Wirkstofffindungsprojekt)
ScheringAG.
Investigador responsável
Schering AG
Concluído
1999 - 2001 Evaluation of synthetic gamma-secretase inhibitors
Schering AG
Investigador responsável
Schering AG
1998 - 1999 Pathophysiological based clinical-chemical diagnosis of dementia: S100B and Abeta-Peptides during Alzheimer´s disease
UMG
Investigador responsável
Universitätsmedizin Göttingen
Concluído
1998 - 1999 Mechanisms of Flupirtin: Studies in primary hippocampal cultures
ASTA
Investigador responsável
ASTA Medica AG
Concluído
1997 - 1999 Pathophysiological based clinical and chemical differential early-onset diagnosis of dementia
VERUM
Investigador responsável
VERUM - Stiftung für Verhalten und Umwelt
Concluído
1995 - 1997 Effects of Psychopharmaca on Cerebral Endothelial Cell Function
EBEWE
EBEWE Research initiative
Concluído
Produções

Publicações

Artigo em revista
  1. Maier, Hannah Benedictine; Stadler, Jan; Deest-Gaubatz, Stephanie; Borlak, Francesca; Türker, Seda Nur; Konen, Franz Felix; Seifert, Johanna; et al. "The significance of cerebrospinal fluid analysis in the differential diagnosis of 564 psychiatric patients: Multiple sclerosis is more common than autoimmune-encephalitis". Psychiatry Research 333 (2024): 115725. http://dx.doi.org/10.1016/j.psychres.2024.115725.
    Publicado • 10.1016/j.psychres.2024.115725
  2. Morgado, Barbara; Klafki, Hans-Wolfgang; Bauer, Chris; Waniek, Katharina; Esselmann, Hermann; Wirths, Oliver; Hansen, Niels; et al. "Assessment of immunoprecipitation with subsequent immunoassays for the blood-based diagnosis of Alzheimers disease". European Archives of Psychiatry and Clinical Neuroscience (2024): http://dx.doi.org/10.1007/s00406-023-01751-2.
    Publicado • 10.1007/s00406-023-01751-2
  3. Soares Martins, Tânia; Pelech, Steven; Ferreira, Maria; Pinho, Beatriz; Leandro, Kevin; de Almeida, Luís Pereira; Breitling, Benedict; et al. "Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimers Disease". International Journal of Molecular Sciences 25 3 (2024): 1584. http://dx.doi.org/10.3390/ijms25031584.
    Publicado • 10.3390/ijms25031584
  4. Hahn, Lisa; Eickhoff, Simon B; Mueller, Karsten; Schilbach, Leonhard; Barthel, Henryk; Fassbender, Klaus; Fliessbach, Klaus; et al. "Resting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems". eLife 13 (2024): http://dx.doi.org/10.7554/elife.86085.
    Publicado • 10.7554/elife.86085
  5. Hayek, Dayana; Ziegler, Gabriel; Kleineidam, Luca; Brosseron, Frederic; Nemali, Aditya; Vockert, Niklas; Ravichandran, Kishore A.; et al. "Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition". Molecular Psychiatry (2024): http://dx.doi.org/10.1038/s41380-023-02387-3.
    Publicado • 10.1038/s41380-023-02387-3
  6. Teipel, Stefan J.; Dyrba, Martin; Kleineidam, Luca; Brosseron, Frederic; Levin, Fedor; Bruno, Davide; Buerger, Katharina; et al. "Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline". Alzheimer's Dementia (Amst): Diagnosis, Assessment, Disease Monitoring 16 1 (2024): http://dx.doi.org/10.1002/dad2.12510.
    Publicado • 10.1002/dad2.12510
  7. Sadlonova, Monika; Hansen, Niels; Esselmann, Hermann; Celano, Christopher M.; Derad, Carlotta; Asendorf, Thomas; Chebbok, Mohammed; et al. "Preoperative Delirium Risk Screening in Patients Undergoing a Cardiac Surgery: Results from the Prospective Observational FINDERI Study". The American Journal of Geriatric Psychiatry (2023): http://dx.doi.org/10.1016/j.jagp.2023.12.017.
    Publicado • 10.1016/j.jagp.2023.12.017
  8. Nemali, A.; Vockert, N.; Berron, D.; Maas, A.; Bernal, J.; Yakupov, R.; Peters, O.; et al. "Gaussian Process-based prediction of memory performance and biomarker status in ageing and Alzheimer's disease - A systematic model evaluation". Medical Image Analysis 90 (2023): 102913. http://dx.doi.org/10.1016/j.media.2023.102913.
    Publicado • 10.1016/j.media.2023.102913
  9. Stark, Melina; Wolfsgruber, Steffen; Kleineidam, Luca; Frommann, Ingo; Altenstein, Slawek; Bartels, Claudia; Brosseron, Frederic; et al. "Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline". Neurology 101 21 (2023): http://dx.doi.org/10.1212/wnl.0000000000207844.
    Publicado • 10.1212/wnl.0000000000207844
  10. Hansen, Niels; Rentzsch, Kristin; Hirschel, Sina; Wiltfang, Jens; Schott, Björn H.; Malchow, Berend; Bartels, Claudia. "Persisting Verbal Memory Encoding and Recall Deficiency after mGluR5 Autoantibody-Mediated Encephalitis". Brain Sciences 13 11 (2023): 1537. http://dx.doi.org/10.3390/brainsci13111537.
    Publicado • 10.3390/brainsci13111537
  11. Greten, Stephan; Wegner, Florian; Jensen, Ida; Krey, Lea; Rogozinski, Sophia; Fehring, Meret; Heine, Johanne; et al. "The comorbidity and co-medication profile of patients with progressive supranuclear palsy". Journal of Neurology 271 2 (2023): 782-793. http://dx.doi.org/10.1007/s00415-023-12006-4.
    Publicado • 10.1007/s00415-023-12006-4
  12. Demmer, Iris; Belz, Michael; Oberbach, Lea; Hummers, Eva; Wiltfang, Jens; Bartels, Claudia. "Evaluation of satisfaction with and relief vs. workload by a general practitioner-centered dementia care project: early information and support in dementia (FIDEM) in Göttingen, Germany". Der Nervenarzt 94 11 (2023): 1034-1042. http://dx.doi.org/10.1007/s00115-023-01557-6.
    Publicado • 10.1007/s00115-023-01557-6
  13. Klafki, Hans-Wolfgang; Wirths, Oliver; Jahn, Olaf; Morgado, Barbara; Esselmann, Hermann; Wiltfang, Jens. "Blood plasma biomarkers for Alzheimer¿s disease: Aß1-42/1-40 vs. AßX-42/X-40". Clinical Chemistry and Laboratory Medicine (CCLM) 62 2 (2023): e56-e57. http://dx.doi.org/10.1515/cclm-2023-0990.
    Publicado • 10.1515/cclm-2023-0990
  14. Waschkies, Konrad F.; Soch, Joram; Darna, Margarita; Richter, Anni; Altenstein, Slawek; Beyle, Aline; Brosseron, Frederic; et al. "Machine learning-based classification of Alzheimer's disease and its at-risk states using personality traits, anxiety, and depression". International Journal of Geriatric Psychiatry 38 10 (2023): http://dx.doi.org/10.1002/gps.6007.
    Publicado • 10.1002/gps.6007
  15. Teipel, Stefan J; Dyrba, Martin; Levin, Fedor; Altenstein, Slawek; Berger, Moritz; Beyle, Aline; Brosseron, Frederic; et al. "Cognitive Trajectories in Preclinical and Prodromal Alzheimer's Disease Related to Amyloid Status and Brain Atrophy: A Bayesian Approach". Journal of Alzheimer's Disease Reports 7 1 (2023): 1055-1076. http://dx.doi.org/10.3233/adr-230027.
    Publicado • 10.3233/adr-230027
  16. Kaurani, Lalit; Besse, Matthias; Methfessel, Isabel; Methi, Aditi; Zhou, Jiayin; Pradhan, Ranjit; Burkhardt, Susanne; et al. "Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression". Translational Psychiatry 13 1 (2023): http://dx.doi.org/10.1038/s41398-023-02582-4.
    Publicado • 10.1038/s41398-023-02582-4
  17. Besse, Matthias; Belz, Michael; Bartels, Claudia; Herzig, Bettina; Wiltfang, Jens; Zilles-Wegner, David. "The myth of brain damage: no change of neurofilament light chain during transient cognitive side-effects of ECT". European Archives of Psychiatry and Clinical Neuroscience (2023): http://dx.doi.org/10.1007/s00406-023-01686-8.
    Publicado • 10.1007/s00406-023-01686-8
  18. Le Guen, Yann; Luo, Guo; Ambati, Aditya; Damotte, Vincent; Jansen, Iris; Yu, Eric; Nicolas, Aude; et al. "Multiancestry analysis of the HLA locus in Alzheimers and Parkinsons diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes". Proceedings of the National Academy of Sciences 120 36 (2023): http://dx.doi.org/10.1073/pnas.2302720120.
    Publicado • 10.1073/pnas.2302720120
  19. Malchow, Berend; Wiltfang, Jens. "Drug repurposing and new drug targets: perspectives for novel treatment options in mental health disorders". Journal of Neural Transmission 130 8 (2023): 987-988. http://dx.doi.org/10.1007/s00702-023-02671-0.
    Publicado • 10.1007/s00702-023-02671-0
  20. Hansen, Niels; Teegen, Bianca; Hirschel, Sina; Wiltfang, Jens; Schott, Björn H.; Bartels, Claudia; Bouter, Caroline. "Case report: Mixed dementia associated with autoantibodies targeting the vesicular glutamate transporter 2". Frontiers in Psychiatry 14 (2023): http://dx.doi.org/10.3389/fpsyt.2023.1227824.
    Publicado • 10.3389/fpsyt.2023.1227824
  21. Amare, Azmeraw T.; Thalamuthu, Anbupalam; Schubert, Klaus Oliver; Fullerton, Janice M.; Ahmed, Muktar; Hartmann, Simon; Papiol, Sergi; et al. "Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder". Molecular Psychiatry (2023): http://dx.doi.org/10.1038/s41380-023-02149-1.
    Publicado • 10.1038/s41380-023-02149-1
  22. Hansen, Niels; Juhl, Aaron Levin; Grenzer, Insa Maria; Teegen, Bianca; Wiltfang, Jens; Fitzner, Dirk. "Cerebrospinal fluid biomarkers in psychiatric autoimmune encephalitis: a retrospective cohort study". Frontiers in Psychiatry 14 (2023): http://dx.doi.org/10.3389/fpsyt.2023.1165153.
    Publicado • 10.3389/fpsyt.2023.1165153
  23. Senner, Fanny; Schneider-Axmann, Thomas; Kaurani, Lalit; Zimmermann, Jörg; Wiltfang, Jens; von Hagen, Martin; Vogl, Thomas; et al. "Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls". Schizophrenia Research: Cognition 32 (2023): 100280. http://dx.doi.org/10.1016/j.scog.2023.100280.
    Publicado • 10.1016/j.scog.2023.100280
  24. Bernal, Jose; Schreiber, Stefanie; Menze, Inga; Ostendorf, Anna; Pfister, Malte; Geisendörfer, Jonas; Nemali, Aditya; et al. "Arterial hypertension and ß-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study". Alzheimer's Research & Therapy 15 1 (2023): http://dx.doi.org/10.1186/s13195-023-01243-4.
    Publicado • 10.1186/s13195-023-01243-4
  25. Luo, Jiao; Thomassen, Jesper Qvist; Bellenguez, Céline; Grenier-Boley, Benjamin; de Rojas, Itziar; Castillo, Atahualpa; Parveen, Kayenat; et al. "Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease". JAMA Network Open 6 5 (2023): e2313734. http://dx.doi.org/10.1001/jamanetworkopen.2023.13734.
    Publicado • 10.1001/jamanetworkopen.2023.13734
  26. Müller, Sebastian Johannes; Wiltfang, Jens; Hansen, Niels. "Onset matters in dementia with Lewy bodies". Aging 15 9 (2023): 3228-3229. http://dx.doi.org/10.18632/aging.204730.
    Publicado • 10.18632/aging.204730
  27. Hansen, Niels; Rentzsch, Kristin; Hirschel, Sina; Bartels, Claudia; Wiltfang, Jens; Malchow, Berend. "Long-Term Course of Neural Autoantibody-Associated Psychiatric Disorders: Retrospective Data from a Specifically Immunopsychiatric Outpatient Clinic". Antibodies 12 2 (2023): 34. http://dx.doi.org/10.3390/antib12020034.
    Publicado • 10.3390/antib12020034
  28. Hansen, Niels; Teegen, Bianca; Hirschel, Sina; Wiltfang, Jens; Schott, Björn H.; Malchow, Berend; Claudia, Bartels. "Case report: Anti-CARPVIII autoantibody-associated mixed dementia". Frontiers in Psychiatry 14 (2023): http://dx.doi.org/10.3389/fpsyt.2023.1133302.
    Publicado • 10.3389/fpsyt.2023.1133302
  29. Ferreira, Maria J. Cardoso; Soares Martins, Tânia; Alves, Steven R.; Rosa, Ilka Martins; Vogelgsang, Jonathan; Hansen, Niels; Wiltfang, Jens; et al. "Bioinformatic analysis of the SPs and NFTs proteomes unravel putative biomarker candidates for Alzheimer's disease". PROTEOMICS 23 15 (2023): http://dx.doi.org/10.1002/pmic.202200515.
    Publicado • 10.1002/pmic.202200515
  30. Jiang, Xueyan; Hu, Xiaochen; Daamen, Marcel; Wang, Xiaoqi; Fan, Chunqiu; Meiberth, Dix; Spottke, Annika; et al. "Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts". Alzheimer's & Dementia 19 11 (2023): 4922-4934. http://dx.doi.org/10.1002/alz.13068.
    Publicado • 10.1002/alz.13068
  31. Hansen, Niels; Müller, Sebastian Johannes; Khadhraoui, Eya; Ernst, Marielle; Riedel, Christian Heiner; Wiltfang, Jens; Lange, Claudia; Bouter, Carolin. "Psychiatric onset of prodromal dementia with Lewy bodies: Current insights into neuroimaging tools". The World Journal of Biological Psychiatry 24 7 (2023): 558-563. http://dx.doi.org/10.1080/15622975.2023.2191008.
    Publicado • 10.1080/15622975.2023.2191008
  32. Ersoezlue, Ersin; Perneczky, Robert; Tato, Maia; Utecht, Julia; Kurz, Carolin; Häckert, Jan; Guersel, Selim; et al. "A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimers Disease Continuum". Journal of Alzheimer's Disease 92 3 (2023): 925-940. http://dx.doi.org/10.3233/jad-220464.
    Publicado • 10.3233/jad-220464
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  543. Smirnov, A.V.; Tumani, H.; Henne, S.; Barchfeld, S.; Olgemöller, U.; Wiltfang, J.; Lange, P.; Mäder, M.; Nau, R.. "Glutamine synthetase in experimental meningitis: Increased ratio of the subunits 3 and 2 may indicate enhanced activity". Clinica Chimica Acta 292 1-2 (2000): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033974419&partnerID=MN8TOARS.
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  544. Nolte, W.; Ehrenreich, H.; Wiltfang, J.; Pahl, K.; Unterberg, K.; Kamrowski-Kruck, H.; Schindler, C.G.; et al. "Systemic and splanchnic endothelin-1 plasma levels in liver cirrhosis before and after transjugular intrahepatic portosystemic shunt (TIPS)". Liver 20 1 (2000): 60-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033977094&partnerID=MN8TOARS.
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  545. Wiltfang, J.; Esselmann, H.; Smirnov, A.; Maler, M.J.; Bleich, S.; Otto, M.; Bibl, M.; Ruther, E.; Kornhuber, J.. "Basics of molecular biology: Therapeutic approach of Alzheimer's disease | Therapieansatze der Alzheimer-demenz". Notfall Medizin 26 6 (2000): 246-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033914356&partnerID=MN8TOARS.
  546. Bleich, S.; Degner, D.; Wiltfang, J.; Maler, J.M.; Niedmann, P.; Cohrs, S.; Mangholz, A.; et al. "Elevated homocysteine levels in alcohol withdrawal". Alcohol and Alcoholism 35 4 (2000): 351-354. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033865333&partnerID=MN8TOARS.
  547. Rüther, E.; Glaser, A.; Bleich, S.; Degner, D.; Wiltfang, J.. "A prospective PMS study to validate the sensitivity for change of the D- scale in advanced stages of dementia using the NMDA-antagonist memantine". Pharmacopsychiatry 33 3 (2000): 103-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347278758&partnerID=MN8TOARS.
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  548. Kropp, S.; Schlimme, J.; Bleich, S.; Wiltfang, J.; Dietrich, D.E.; Emrich, H.M.. "Diagnostic steps in possible Alzheimer dementia before starting with new therapeutics | Diagnostische schritte bei Alzheimer-demenz vor therapiebeginn mit neuen antidementiva". Fortschritte der Neurologie Psychiatrie 68 6 (2000): 257-261. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033948047&partnerID=MN8TOARS.
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    10.1034/j.1600-0404.2000.9s290A.x
  550. Kornhuber, J.; Bleich, S.; Wiltfang, J.; Maler, M.; Parsons, C.G.. "Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels". Journal of Neural Transmission 106 9-10 (1999): 857-867. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032726988&partnerID=MN8TOARS.
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  551. Kornhuber, J.; Maler, M.; Wiltfang, J.; Bleich, S.; Degner, D.; Rüther, E.. "Opening of neuronal K+ channels by flupirtine | Neuronale kaliumkanaloffnung durch flupirtin". Fortschritte der Neurologie Psychiatrie 67 10 (1999): 466-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032708985&partnerID=MN8TOARS.
  552. Steinhoff, B.J.; Tumani, H.; Otto, M.; Mursch, K.; Wiltfang, J.; Herrendorf, G.; Bittermann, H.-J.; et al. "Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy". Epilepsy Research 36 1 (1999): 75-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032775645&partnerID=MN8TOARS.
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  553. Otto, M.; Wiltfang, J.; Poser, S.; Kornhuber, J.; Burger, K.; Padberg, F.; Moller, H.-J.; Hampel, H.. "Tau protein: A potential biological indicator for early recognition of Alzheimer's disease [1] (multiple letters) | Anmerkung zur Arbeit von K. Buch et al.: Tau protein: Ein potentieller biologischer indikator zur fruherkennung der Alzheimer-Krankheit. Nervenarzt (1998) 69:379-385". Nervenarzt 70 7 (1999): 668-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032812277&partnerID=MN8TOARS.
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  554. Lewczuk, P.; Wiltfang, J.; Lange, M.; Jahn, H.; Reiber, H.; Ehrenreich, H.. "Prothrombin concentration in the cerebrospinal fluid is not altered in Alzheimer's disease". Neurochemical Research 24 12 (1999): 1531-1534. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032727703&partnerID=MN8TOARS.
  555. Beekes, M.; Otto, M.; Wiltfang, J.; Bahn, E.; Poser, S.; Baier, M.. "Late increase of serum S100 ß protein levels in hamsters after oral or intraperitoneal infection with scrapie". Journal of Infectious Diseases 180 2 (1999): 518-520. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033495904&partnerID=MN8TOARS.
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  556. Wiltfang, J.; Nolte, W.; Otto, M.; Wildberg, J.; Bahn, E.; Figulla, H.R.; Pralle, L.; et al. "Elevated serum levels of astroglial S100ß in patients with liver cirrhosis indicate early and subclinical portal-systemic encephalopathy". Metabolic Brain Disease 14 4 (1999): 239-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033506555&partnerID=MN8TOARS.
  557. Wiltfang, J.; Otto, M.; Baxter, H.C.; Bodemer, M.; Steinacker, P.; Bahn, E.; Zerr, I.; et al. "Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease". Journal of Neurochemistry 73 6 (1999): 2485-2490. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032750754&partnerID=MN8TOARS.
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  558. Wiltfang, J.; Klotz, S.; Jordan, W.; Cohrs, S.; Engelbe, W.; Hajak, G.. "First results on daytime submandibular electrostimulation of suprahyoidal muscles to prevent night-time hypopharyngeal collapse in obstructive sleep apnea syndrome". International Journal of Oral and Maxillofacial Surgery 28 1 (1999): 21-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033073087&partnerID=MN8TOARS.
  559. Kornhuber, J.; Wiltfang, J.. "Erratum: The role of glutamate in dementia (Journal of Neural Transmission (Suppl) (1998) 53, (277-287))". Journal of Neural Transmission 106 2 (1999): http://www.scopus.com/inward/record.url?eid=2-s2.0-0032984539&partnerID=MN8TOARS.
  560. Kornhuber, J.; Jellinger, K.; Wiltfang, J.; Leblhuber, F.; Riederer, P.. "The N-methyl-D-aspartate receptor channel blocker amantadine does not cause histopathological alterations in human brain tissue". Acta Neuropathologica 98 1 (1999): 85-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033057806&partnerID=MN8TOARS.
    10.1007/s004010051054
  561. Tumani, H.; Otto, M.; Gefeller, O.; Wiltfang, J.; Herrendorf, G.; Mogge, S.; Steinhoff, B.J.. "Kinetics of serum neuron-specific enolase and prolactin in patients after single epileptic seizures". Epilepsia 40 6 (1999): 713-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032976527&partnerID=MN8TOARS.
    10.1111/j.1528-1157.1999.tb00768.x
  562. Kornhuber, J.; Schultz, A.; Wiltfang, J.; Meineke, I.; Gleiter, C.H.; Zöchling, R.; Boissl, K.-W.; Leblhuber, F.; Riederer, P.. "Persistence of haloperidol in human brain tissue". American Journal of Psychiatry 156 6 (1999): 885-890. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033009682&partnerID=MN8TOARS.
    10.1176/ajp.156.6.885
  563. Hulstaert, F.; Blennow, K.; Ivanoiu, A.; Schoonderwaldt, H.C.; Riemenschneider, M.; De Deyn, P.P.; Bancher, C.; et al. "Improved discrimination of AD patients using ß-amyloid((1-42)) and tau levels in CSF". Neurology 52 8 (1999): 1555-1562. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033549069&partnerID=MN8TOARS.
  564. Wiltfang, J.; Nolte, W.; Weißenborn, K.; Kornhuber, J.; Rüther, E.. "Psychiatric aspects of portal-systemic encephalopathy". Metabolic Brain Disease 13 4 (1998): 379-389. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032408193&partnerID=MN8TOARS.
    10.1023/A:1020697127718
  565. Otto, M.; Beekes, M.; Wiltfang, J.; Bahn, E.; Poser, S.; Diringer, H.. "Elevated levels of serum S100 beta protein in scrapie hamsters [1]". Journal of NeuroVirology 4 5 (1998): 572-573. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031740191&partnerID=MN8TOARS.
  566. Otto, M.; Wiltfang, J.; Schütz, E.; Zerr, I.; Otto, A.; Pfahlberg, A.; Gefeller, O.; et al. "Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: Prospective case-control study". British Medical Journal 316 7131 (1998): 577-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-6844255891&partnerID=MN8TOARS.
  567. Otto, M.; Bahn, E.; Wiltfang, J.; Boekhoff, I.; Beuche, W.. "Decrease of S100 beta protein in serum of patients with amyotrophic lateral sclerosis". Neuroscience Letters 240 3 (1998): 171-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032535979&partnerID=MN8TOARS.
    10.1016/S0304-3940(97)00947-6
  568. Zerr, I.; Bodemer, M.; Gefeller, O.; Otto, M.; Poser, S.; Wiltfang, J.; Windl, O.; Kretzschmar, H.A.; Weber, T.. "Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease". Annals of Neurology 43 1 (1998): 32-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031914675&partnerID=MN8TOARS.
    10.1002/ana.410430109
  569. Nolte, W.; Wiltfang, J.; Schindler, C.; Münke, H.; Unterberg, K.; Zumhasch, U.; Figulla, H.R.; et al. "Portosystemic hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis: Clinical, laboratory, psychometric, and electroencephalographic investigations". Hepatology 28 5 (1998): 1215-1225. http://www.scopus.com/inward/record.url?eid=2-s2.0-17344366697&partnerID=MN8TOARS.
    10.1002/hep.510280508
  570. Nolte, W.; Wiltfang, J.; Schindler, C.G.; Unterberg, K.; Finkenstaedt, M.; Niedmann, P.D.; Hartmann, H.; Ramadori, G.. "Bright basal ganglia in T1-weighted magnetic resonance images are frequent in patients with portal vein thrombosis without liver cirrhosis and not suggestive of hepatic encephalopathy". Journal of Hepatology 29 3 (1998): 443-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032171540&partnerID=MN8TOARS.
    10.1016/S0168-8278(98)80063-9
  571. Kornbuber, J.; Wiltfang, J.. "The role of glutamate in dementia". Journal of Neural Transmission, Supplement 53 (1998): 277-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031596274&partnerID=MN8TOARS.
  572. Huether, G.; Zhou, D.; Schmidt, S.; Wiltfang, J.; Rüther, E.. "Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex". Biological Psychiatry 41 12 (1997): 1174-1180. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030927582&partnerID=MN8TOARS.
    10.1016/S0006-3223(96)00265-X
  573. Otto, M.; Wiltfang, J.; Tumani, H.; Zerr, I.; Lantsch, M.; Kornhuber, J.; Weber, T.; Kretzschmar, H.A.; Poser, S.. "Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease". Neuroscience Letters 225 3 (1997): 210-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030934518&partnerID=MN8TOARS.
    10.1016/S0304-3940(97)00215-2
  574. Nolte, W.; Figulla, H.R.; Ringe, B.; Wiltfang, J.; Münke, H.; Hartmann, H.; Ramadori, G.. "Transjugular intrahepatic portosystemic stent shunt (TIPSS) in Budd-Chiari syndrome with portal vein thrombosis | TIPSS bei Budd-Chiari-Syndrom mit Portalvenenthrombose". Deutsche Medizinische Wochenschrift 122 5 (1997): 116-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031050112&partnerID=MN8TOARS.
  575. Wiltfang, J.; Smirnov, A.; Schnierstein, B.; Kelemen, G.; Matthies, U.; Klafki, H.-W.; Staufenbiel, M.; et al. "Improved electrophoretic separation and immunoblotting of beta-amyloid (Aß) peptides 1-40, 1-42, and 1-43". Electrophoresis 18 3-4 (1997): 527-532. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030951595&partnerID=MN8TOARS.
    10.1002/elps.1150180332
  576. Zhou, D.; Huether, G.; Wiltfang, J.; Hajak, G.; Rüther, E.. "Serotonin transporters in the rat frontal cortex: Lack of circadian rhythmicity but down-regulation by food restriction". Journal of Neurochemistry 67 2 (1996): 656-661. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030036983&partnerID=MN8TOARS.
  577. Klafki, H.-W.; Wiltfang, J.; Staufenbiel, M.. "Electrophoretic separation of ßA4 peptides (1-40) and (1-42)". Analytical Biochemistry 237 1 (1996): 24-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029665851&partnerID=MN8TOARS.
    10.1006/abio.1996.0195
  578. Michel, U.; Schneider, O.; Kirchhof, C.; Meisel, S.; Smirnov, A.; Wiltfang, J.; Rieckmann, P.. "Production of follistatin in porcine endothelial cells: Differential regulation by bacterial compounds and the synthetic glucocorticoid RU 28362". Endocrinology 137 11 (1996): 4925-4934. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029851397&partnerID=MN8TOARS.
    10.1210/en.137.11.4925
  579. Nolte, W.; Wiltfang, J.-G.; Kunert, H.-J.; Thiel, A.; Geese, K.; Peters, K.; Figulla, H.R.; Hartmann, H.; Ramadori, G.. "First clinical experience with TIPS (transjugular intrahepatic portosystemic stent-shunt) | ERSTE KLINISCHE ERFAHRUNGEN MIT TIPS (TRANSJUGULARER INTRAHEPATISCHER PORTOSYSTEMISCHER STENT-SHUNT)". Leber Magen Darm 25 6 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029591382&partnerID=MN8TOARS.
  580. Rieckmann, P.; Nunke, K.; Burchhardt, M.; Albrecht, M.; Wiltfang, J.; Ulrich, M.; Felgenhauer, K.. "Soluble intercellular adhesion molecule-1 in cerebrospinal fluid: An indicator for the inflammatory impairment of the blood-cerebrospinal fluid barrier". Journal of Neuroimmunology 47 2 (1993): 133-140. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027361834&partnerID=MN8TOARS.
    10.1016/0165-5728(93)90023-R
  581. Müller-Spahn, F.; Hüther, G.; Schinschke, S.; Stoppe, G.; Wiltfang, J.. "Serum melatonin, 5-HT and tryptophan levels in blood and CSF in the diagnosis of early dementia and depressive pseudodementia". European Neuropsychopharmacology 1 3 (1991): http://www.scopus.com/inward/record.url?eid=2-s2.0-44949279323&partnerID=MN8TOARS.
  582. Wiltfang, J.; Arold, N.; Neuhoff, V.. "A new multiphasic buffer system for sodium dodecyl sulfate-polyacrylamide gel electrophoresis of proteins and peptides with molecular masses 100000 - 1000, and their detection with picomolar sensitivity". Electrophoresis 12 5 (1991): 352-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025782516&partnerID=MN8TOARS.
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  584. Kratzin, H.D.; Wiltfang, J.; Karas, M.; Neuhoff, V.; Hilschmann, N.. "Gas-phase sequencing after electroblotting on polyvinylidene difluoride membranes assigns correct molecular weights to myoglobin molecular weight markers". Analytical Biochemistry 183 1 (1989): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024341206&partnerID=MN8TOARS.
    10.1016/0003-2697(89)90161-9
Capítulo de livro
  1. Vogelgsang, J.; Wiltfang, J.; Klafki, H.W.. "Validation of a chemiluminescence immunoassay for measuring amyloid-ß in human blood plasma". 111-124. 2018.
    10.1007/978-1-4939-7704-8_7
  2. Wiltfang, Jens; Lewczuk, P.. "Clinical Neuroproteomics of Human Body Fluids: CSF and Blood Assays for Early and Differential Diagnosis of Dementia". In Proteomics in Drug Research, 259-278. Wiley, 2006.
    Publicado • 10.1002/3527608230
Livro
  1. Wedekind, D.; Spitzer, C.; Wiltfang, Jens; Koller, M.; Rüther, E.; Hauth, I.; Häfner, H.; et al. 150 Years of Psychiatry at Göttingen University: Lectures given at the Anniversary Symposium. V&R Unipress. 2019.
    Publicado
Poster em conferência
  1. Soares Martins, T.; Pelech, S.; Ferreira, M.J.; Breitling, B.; Hansen, N.; Esselmann, H.; Wiltfang, Jens; Da Cruz E Silva, O.A.B.; Henriques, A.G.. "Blood-derived extracellular vesicles proteome and phosphoproteome profiling in Alzheimers disease through microarray analysis". Trabalho apresentado em AD/PD 2024, 2024.
  2. Soares Martins, T.; Magalhães, S.; Rosa, I.M.; Vogelgsang, J.; Wiltfang, Jens; Delgadillo, I.; Catita, J.; et al. "Fourier Transformed Infrared Spectroscopy of Extracellular Vesicles as a Diagnostic Tool for Alzheimers Disease". Trabalho apresentado em GEIVEX, 2019.
  3. Soares Martins, T.; Magalhães, S.; Rosa, I.M.; Vogelgsang, J.; Wiltfang, Jens; Da Cruz E Silva, O.A.B.; Nunes, A.; Henriques, A.G.. "FTIR spectral analysis of serum samples from Alzheimer´s disease cases: a pilot study". Trabalho apresentado em V iBiMED Post-Graduation Symposium, 2019.
  4. Wirths, O.; Ogorek, I.; Klafki, H.; Otto, C.; Stadelmann, C.; Weggen, S.; Wiltfang, Jens; Hüttenrauch, M.. "Glycoprotein NMB: A novel Alzheimer's disease associated marker expressed in a subset of activated microglia". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Disease, 2019.
  5. Shahpasand-Kroner, H.; Klafki, H.; Bauer, C.; Schuchhardt, J.; Hüttenrauch, M.; Stazi, M.; Bouter, C.; et al. "Magnetic bead immunoprecipitation facilitates the measurement of Ab-rations in blood plasma as peripheral alzheimer's disease biomarkers". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Disease, 2019.
  6. Vogelgsang, J.; Santos, J.; Bauer, C.; Schuchhardt, J.; Da Cruz E Silva, O.A.B.; Waniek, K.; Lachmann, I.; Wiltfang, Jens. "P231 Tau CSF assay validation and its potential use in the differential diagnosis of dementia". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Disease, 2019.
  7. Stazi, M.; Klafki, H.; Wiltfang, Jens; Wirths, O.. "Beneficial effect of caffeine and memantine in the TG4-42 mouse model of Alzheimer's Disease". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Disease, 2019.
  8. Zampar, S.; Hornung, K.; Klafki, H.; Bayer, T.A.; Wiltfang, Jens; Jahn, O.; Wirths, O.. "N-terminal truncated Abeta4-42 is a substrate for neprilysin degradation in vitro and in vivo". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Disease, 2019.
  9. Steinacker, P.; Anderl-Straub, S.; Diehl-Schmid, J.; Semler, E.; Uttner, I.; von Arnim, C.A.F.; Barthel, H.; et al. "Serum neurofilament light chain and regional brain atrophy in beahavioral variant frontotemporal dementia and Alzheimer's disease". Trabalho apresentado em The 14th International Conference on Alzheimer's & Parkinson's Disease, 2019.

Propriedade Intelectual

Patente
  1. Gerwert, K.; Wiltfang, Jens; Ollesch, J.; Naber, A.; Schartner, J.; Kötting, C.. 2017. "Biosensor for Conformation and Secondary Structure Analysis".
  2. Wiltfang, Jens. 2013. "NEW FORMULATIONS FOR DIAGNOSIS OF ALZHEIMER'S DISEASE Publication number: 20130045542".
  3. Lueking, A.; Müllner, S.; Teunissen, C.; Wiltfang, Jens. 2013. "BIOMARKERS FOR ALZHEIMER'S DISEASE".
  4. Wiltfang, Jens. 2009. "Method of Differentially Diagnosing Dementias".
  5. Wiltfang, Jens; Lweczuk, P.; Kornhuber, J.. 2006. "Diagnosis of Alzheimer's disease".
  6. Wiltfang, Jens; Dyrks, T.; Mönning, U.. 2005. "Monoclonal antibody".
  7. Wiltfang, Jens; Dyrks, T.; Mönning, U.. 2003. "Monoclonal antibody".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/03/30 Subjecting blood-derived extracelular vesicles to FTIR spectroscopy towards AD diagnosis AD/PD 2023
(Gothenburg, Suécia)
2023 Blood-derived extracellular vesicles metabolic signatures in Alzheimer´s disease VI Symposium iBiMED
2022/03/02 New methodologies for diagnosing Alzheimer's disease from blood Emerging Technologies to Diagnose Alzheimer's Disease
Universidade de Aveiro (Aveiro, Portugal)
2020/09/25 Alzheimers disease cases discrimination by FTIR spectroscopy of exosomes
2019/11/27 Blutbasierte Prädiktionsmarker zur Frühdiagnostik der Alzheimer-Demenz DGPPN
(Berlin, Alemanha)
2019/11/06 Fourier Transformed Infrared Spectroscopy of Extracellular Vesicles as a Diagnostic Tool for Alzheimer’s Disease 5th GEIVEX Symposium
(Granada, Espanha)
2019/10/21 Blood based diagnosis of preclinical Alzheimer's Dementia: a novel recruitment tool for prevention studies? EADC Meeting
(Amsterdam, Países Baixos)
2019/09/13 Blood based diagnosis of preclinical Alzheimers Dementia: perspective for new clinical models Hansesymposium
(Rostock, Alemanha)
2019/03/27 The secreted metalloprotease ADAMS4 generates N-truncated Abeta4-X peptides and is exclusively expressed in oligodendrocytes The 14th International Conference on Alzheimer's & Parkinson's Disease
(Lisbon, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2020/01/24 - Atual Longitudinale Evaluation des Gedächtniskonsolidierungsdefizits sowie der Hippocampus-Konnektivität bei depressiven Patienten im Rahmen der Behandlung mit Antidepressiva
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2020/01/06 - Atual Psychopathologie bei Hörminderung
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2019/10/04 - Atual Auswirkungen der Depressionsbehandlung auf die Selbsteinschätzung des frühen Traumas
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2019/07/17 - Atual Understanding the functional role of lipid transmitters in the regulation of appetite in obesity in humans
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2019/06/24 - Atual Aß-Signatur für den Subphänotyp schnell progredienter Patienten mit sporadischer Alzheimer Demenz
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2019/06/17 - Atual Kombination einer blutbasierten und PET-Diagnostik zur Frühdiagnose der Alzheimer-Demenz
Orientador
2019/06/17 - Atual Machbarkeitsstudie zur ersten Überprüfung einer computerbasierten, therapeutengestützten Intervention für Menschen mit einem selbstberichteten sexuellen Interesse an Kindern und Jugendlichen
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2019/01/09 - Atual Transsexualität – Welche Rolle spielt Geschlechteridentität im beruflichen Alltag von Hausärzt/innen
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2018/12/14 - Atual Automatische Klassifikation pathologischer selbstreferenzieller kognitiver Prozesse bei depressiven Erkrankungen auf der Basis physiologischer und motorischer Daten
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2018/10 - Atual Blood-derived exosomes for biomarker discovery in AD - BMKDisc-AD
Coorientador de Tânia Cristina Soares Martins
Biomedicine (Doutoramento)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2017/01/31 - Atual Authentizität von Stimulationspatienten in Lehrvideos
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2016/02/22 - Atual Effekte von speziell konzipierten Konzerten für Menschen mit Demenz und ihre Angehörigen im Rahmen der Konzertreihe „Auf Flügeln der Musik“
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2018/04/08 - 2022/07/19 Einfluss von prä-analytischen Entnahme- und Lagerungs-bedingungen auf die Stabilität und Konzentration von Amyloid-beta-Proteinen
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2019/01/19 - 2022/01/14 Untersuchungen zu Amyloid-ß Peptiden im humanen Blutplasma als Biomarkerkandidaten der Alzheimerkrnakheit
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2018/03/15 - 2021/06/10 Neurofilament light chain als Prädiktor bei Mild Cognitive Impairment
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2015/10/07 - 2020/08/31 Deskriptive Studie zur zahnärztlichen Betreuung und Versorgung demenzkranker Patienten im Raum Göttingen
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2017 - 2020 Bacterial infections among patients with psychiatric disorders: Relation with hospital stay, age, and psychiatric diagnoses
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2015 - 2018/08/13 The Quality of Inpatient Treatment of People with Dementia - An Analysis based on a German Indicator Project in Psychiatric Hospitals (VIPP project)
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2016 - 2017/12/13 TAU Thr231 phosphorylation as a potential Alzheimer's disease biomarker
Orientador de Joana Rita Faneca Santos
Molecular Biomedicine (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2013 - 2016/11/09 How to handle individual pathologic findings in biobank-research
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
2005 - 2008 Neurochemische Diagnostik der Alzheimer-Demenz: Differenzialdiagnostische Wertigkeit der biochemischen Marker Abeta 1-42, Abeta 1-42/1-40 und Gesamt-Tau einzeln und in Kombination zueinander bezüglich der Unterscheidung der AD von nAD bzw.
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
1999 - 2002 Regulation der Freisetzung des neuroprotektiven/neurotoxischen Zytokins S100B sowie von NGF nach Stimulation von Rattenastrozytenkulturen mit Interleukin-1ß und LPS
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
1997 - 2000 Neurochemische Diagnostik der Alzheimer-Demenz: Attomolar-sensitiver Nachweis von Aß-Peptiden im lumbalen Liquor mittels Aß-SDS-PAGE/Immunoblot
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
1997 - 2000 Metabolisch bedingte elektroenzephalographische Veränderungen bei Patienten mit portosystemischer Enzephalopathie nach Implantation eines transjugulären intrahepatischen portosystemischen Stent-Shunt (TIPS)
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
1997 - 2000 Portosystemische Enzephalopathie bei Patienten mit portaler Hypertension und transjugulärem intrahepatischen portosystemischen Stent-Shunt (TIPS)
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
1997 - 2000 Die portosystemische Enzephalopathie: Eine Verlaufsbeobachtung über drei Jahre bei Patienten mit transjugulärem intrahepatischen portosystemischen Stent-Shunt (TIPS)
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha
1994 - 1997 Metabolisch-bedingte Schlafstörungen: Untersuchungen bei Patienten mit portosystemischer Enzephalopathie (PSE) am Modell des transjugulären intrahepatischen portosystemichen Stent-Shunt (TIPS)
Orientador
Universitätsmedizin Göttingen Klinik für Psychiatrie und Psychotherapie, Alemanha

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019/11/27 - 2019/11/30 Organisation and Chair of Symposium at DGPPN des Referat für Prädiktive Psychiatrie: Title: Prädiktionsmarker für psychiatrische Erkrankungen – State of the Art (2019/11/27 - 2019/11/30)
Simpósio (Membro da Comissão Organizadora)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2019/10/21 - 2019/10/22 EADC Meeting
Congresso
EADC Meeting
2019/09/13 - 2019/09/14 Hansesymposium
Simpósio
Hansesymposium
2019/09/06 - 2019/09/08 ECNP Congress
Conferência
ECNP Congress

Membro de associação

Nome da associação Tipo de participação
2016 - Atual Society for CSF analysis and clinical neurochemistry
2013/10 - Atual Ethics Committee of the University Medical Center Goettingen
2013 - Atual Member European Alzheimer Disease Consortium
2008 - Atual National Comission for Diagnostic & Therapeutic Dementia Guidelines
2002 - Atual German Society for CSF Diagnostics and Clinical Neurochemistry
2000 - Atual Neuropsychopharmakologie und Pharmakotherapie
2004 - 2013 Human Brain Proteome Project
2008 - 2010 Council of the Medical Faculty

Tutoria

Tópico Nome do aluno
2018/01/14 - 2018/04/14 Erasmus fellowship Joana Rita Faneca Santos
2015/02/09 - 2015/06/26 Erasmus fellowship Sérgio Paulo
Distinções

Prémio

2015 ZukunftErfinden NRW
North-Rhine Westphalia University Competition 2011, Alemanha
2013 Neuroallianz Publication Award 2013 in Bronze
German Federal Ministry for Education and Research (BMBF), Alemanha
2012 Scientific Award “ZukunftErfinden NRW”
North-Rhine Westphalia University Competition 2011, Alemanha
2012 Neuroallianz Publication Award 2012 in Gold
German Federal Ministry for Education and Research (BMBF), Alemanha
2005 Poster award
8th World Congress of Biological Psychiatry, Áustria
2005 Young scientist award
8th World Congress of Biological Psychiatry, Áustria
2005 Young scientist award
AG für Neuropsychopharma¬kologie und Pharmakotherapie , Alemanha
2003 Award for brain research
Center for geriatric research, University of Witten-Herdecke, Germany, Alemanha
2002 Organon-Science Award
2000 Organon Research Award
Deutschen Gesellschaft für Biologische Psychiatrie, Alemanha
1999 Science Award
International Gastroenterology Foundation, Alemanha
1995 Poster award
AG für Neuropsychopharma¬kologie und Pharmakotherapie , Alemanha
1991 Founder Award