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Antonio Martínez Ruiz. Concluiu o(a) Doctor em Doctorado en Bioquímica y Biología Molecular em 2000/05/18 pelo(a) Universidad Complutense de Madrid e Licence em Ciencias Químicas - Bioquímica em 1995 pelo(a) Universidad Complutense de Madrid. É Investigador principal (carreira) no(a) Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa e Leitor no(a) Universidad Complutense de Madrid. Publicou 71 artigos em revistas especializadas (unho aceite para publicaçao em Nature). Recebeu 3 prémio(s) e/ou homenagens. Participa e/ou participou como Investigador responsável em 10 projeto(s). Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Bioquímica e Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Métodos de Investigação Bioquímica. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: redox signalling; oxidative post-translational modifications; hypoxia adaptation; cysteine oxidation; proteomics methods; reactive oxygen species; reactive nitrogen species; reactive sulfur species; .
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Identificação

Identificação pessoal

Nome completo
Antonio Martínez Ruiz

Nomes de citação

  • Martínez-Ruiz, Antonio

Identificadores de autor

Ciência ID
C913-692D-C3AA
ORCID iD
0000-0001-5394-9824
Researcher Id
A-5672-2009
Scopus Author Id
6701506815

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Métodos de Investigação Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Espanhol; Castelhano Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B2)
Italiano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador independente (B1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2000/05/18
Concluído
 Doctorado en Bioquímica y Biología Molecular (Doctor)
Universidad Complutense de Madrid, Espanha
"Estudio de las relaciones estructura-función en toxinas proteicas de "Aspergillus" : secreción y actividad ribonucleolítica" (TESE/DISSERTAÇÃO)
 Sobresaliente cum laude
1995
Concluído
 Ciencias Químicas - Bioquímica (Licence)
Universidad Complutense de Madrid, Espanha
"n/a" (TESE/DISSERTAÇÃO)
 Matrícula de Honor - Premio Extraordinario
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2008/02/18 - Atual Investigador principal (carreira) (Investigação) Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
2004/02/17 - 2008/02/17 Investigador principal (carreira) (Investigação) Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Espanha
2000/04/01 - 2004/02/16 Pós-doutorado (Investigação) Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Espanha
2002/09/01 - 2002/10/16 Investigador visitante (Investigação) Karolinska Institutet, Suécia
1997/07 - 1997/10 Investigador visitante (Investigação) The University of British Columbia, Canadá

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/11 - Atual Leitor (Docente Universitário) Universidad Complutense de Madrid, Espanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
1995/07/01 - 2000/03/31 Predoctoral fellow / early stage researcher Universidad Complutense de Madrid, Espanha
Projetos

Projeto

Designação Financiadores
2019/01 - 2021/12 Oxidative damage in reperfusion after stroke: proteomic detection of redox targets and role of the mitochondrial sodium/calcium exchanger NCLX (RedoxStroke)
RTI2018-094203-B-I00
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Gobierno de España Agencia Estatal de Investigación
Em curso
2016/01 - 2018/12 Hypoxia signalling by reactive oxygen species, and redox proteomics: from molecular mechanisms to clinical applications
PI15/00107
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Instituto de Salud Carlos III
Concluído
2013/01 - 2015/12 Oxidative post-translational modifications in molecular pathophysiology
PI12/00875
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Instituto de Salud Carlos III
Concluído
2014 - 2015 Implications of hypoxia and reactive oxygen species in neurodegenerative diseases
sem código
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Fundación Domingo Martínez
Concluído
2011 - 2013 Identification of the S-nitrosylation targets of NO in the stimulation of endogenous neurogenesis
PRI-AIBPT-2011-1015
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Gobierno de España Ministerio de Ciencia e Innovación
Concluído
2011 - 2013 Proteomic identification of S-nitrosylated plant proteins in the response to auxin
PRI-AIBAR-2011-0782
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Gobierno de España Ministerio de Ciencia e Innovación
Concluído
2011 - 2013 Proteomic identification of S-nitrosylated plant proteins in the response to auxin
PRI-AIBAR-2011-0782
 Gobierno de España Ministerio de Ciencia e Innovación
2011 - 2013 Identification of the S-nitrosylation targets of NO in the stimulation of endogenous neurogenesis
PRI-AIBPT-2011-1015
 Gobierno de España Ministerio de Ciencia e Innovación
2010/01 - 2012/12 Role of reactive oxygen and nitrogen species and of protein post-translational modifications in the response to hypoxia in cardiovascular pathophysyology
PS09/00101
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Instituto de Salud Carlos III
Concluído
2007/12 - 2012/12 “Functional role of oxidative and nitrosative stress in biological systems” (ROSAS Network, “Reactive Oxygen Species and Systems”)
CSD2007-00020
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Ministerio de Educación y Ciencia, Gobierno de España
Concluído
2008/02 - 2011/02 Role of post-translational modifications induced by reactive oxygen and nitrogen species in hypoxia signalling in cardiovascular pathophysyology settings
CP07/00143
Investigador responsável
Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, Espanha
 Instituto de Salud Carlos III
Concluído
2008/02 - 2011/02 Role of post-translational modifications induced by reactive oxygen and nitrogen species in hypoxia signalling in cardiovascular pathophysyology settings
CP07/00143
 Instituto de Salud Carlos III
2004/02 - 2007/02 Post-translational modifications induced by oxidative and nitrosative stress in proteins from vascular endothelium: proteomic identification and functional evaluation
CP03/00025
Investigador responsável
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Espanha
 Instituto de Salud Carlos III
Concluído
2004/02 - 2007/02 Post-translational modifications induced by oxidative and nitrosative stress in proteins from vascular endothelium: proteomic identification and functional evaluation
CP03/00025
 Instituto de Salud Carlos III
Produções

Publicações

Artigo em revista
  1. Estefanía Caballano-Infantes; Irene Díaz; Ana Belén Hitos; Gladys Margot Cahuana; Antonio Martínez-Ruiz; Bárbara Soria-Juan; Rosario Rodríguez-Griñolo; et al. "Stemness of Human Pluripotent Cells: Hypoxia-Like Response Induced by Low Nitric Oxide". Antioxidants 10 9 (2021): 1408-1408. https://doi.org/10.3390/antiox10091408.
    10.3390/antiox10091408
  2. Hernansanz-Agustín, Pablo; Choya-Foces, Carmen; Carregal-Romero, Susana; Ramos, Elena; Oliva, Tamara; Villa-Piña, Tamara; Moreno, Laura; et al. "Na+ controls hypoxic signalling by the mitochondrial respiratory chain". Nature 586 7828 (2020): 287-291. http://dx.doi.org/10.1038/s41586-020-2551-y.
    10.1038/s41586-020-2551-y
  3. Ghashghaeinia, Mehrdad; Koralkova, Pavla; Giustarini, Daniela; Mojzikova, Renata; Fehrenbacher, Birgit; Dreischer, Peter; Schaller, Martin; et al. "The specific PKC-a inhibitor chelerythrine blunts costunolide-induced eryptosis". Apoptosis 25 9-10 (2020): 674-685. http://dx.doi.org/10.1007/s10495-020-01620-6.
    10.1007/s10495-020-01620-6
  4. Martínez-Ruiz, Antonio. "Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer.". Redox biology (2020): https://europepmc.org/articles/PMC7210585.
    10.1016/j.redox.2020.101528
  5. Prieto, Ignacio; Rubio Alarcon, Carmen; Garcia-Gomez, Raquel; Berdun, Rebeca; Urgel, Tamara; Portero, Manuel; Pamplona, Reinald; et al. "Metabolic adaptations in spontaneously immortalized PGC-1 alpha knock-out mouse embryonic fibroblasts increase their oncogenic potential". Redox Biology (2020): https://publons.com/publon/21892791/.
    10.1016/J.REDOX.2019.101396
  6. Ana Isabel Santos; Ana Sofia Lourenço; Sónia Simão; Dorinda Marques da Silva; Daniela Filipa Santos; Ana Paula Onofre de Carvalho; Ana Catarina Pereira; et al. "Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics". Redox Biology 32 (2020): 101457. https://publons.com/publon/30600805/.
    Publicado • 10.1016/J.REDOX.2020.101457
  7. Carlos Lopez-Rodriguez, Juan; Manosalva, Juliana; Daniel Cabrera-Garcia, J.; Escribese, Maria M.; Villalba, Mayte; Barber, Domingo; Martinez-Ruiz, Antonio; Batanero, Eva. "Human glutathione-S-transferase pi potentiates the cysteine-protease activity of the Der p 1 allergen from house dust mite through a cysteine redox mechanism". Redox Biology (2019): https://publons.com/publon/21417775/.
    10.1016/J.REDOX.2019.101256
  8. Francisco Sanchez-Madrid; María Jesús Domínguez-Luis; Estefanía Armas-González; Ada Herrera-García; María Arce-Franco; Manuel Feria; Miguel Vicente-Manzanares; et al. "L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling". European Journal of Immunology (2019): https://publons.com/publon/17308486/.
    10.1002/EJI.201847710
  9. Melendez-Rodriguez, Florinda; Urrutia, Andres A.; Lorendeau, Doriane; Rinaldi, Gianmarco; Roche, Olga; Boeguercue-Seidel, Nuray; Ortega Muelas, Marta; et al. "HIF1 alpha Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis". Cell Reports (2019): https://publons.com/publon/19010135/.
    10.1016/J.CELREP.2019.01.106
  10. Santos, Ana Isabel; Carreira, Bruno Pereira; Izquierdo-Alvarez, Alicia; Ramos, Elena; Lourenco, Ana Sofia; Santos, Daniela Filipa; Morte, Maria Ines; et al. "S-Nitrosylation of Ras Mediates Nitric Oxide-Dependent Post-Injury Neurogenesis in a Seizure Model". Antioxidants & Redox Signaling (2018): https://publons.com/publon/4142085/.
    10.1089/ARS.2016.6858
  11. Santofimia-Castano, Patricia; Izquierdo-Alvarez, Alicia; Plaza-Davila, Maria; Martinez-Ruiz, Antonio; Fernandez-Bermejo, Miguel; Mateos-Rodriguez, Jose M.; Salido, Gines M.; Gonzalez, Antonio. "Ebselen impairs cellular oxidative state and induces endoplasmic reticulum stress and activation of crucial mitogen-activated protein kinases in pancreatic tumour AR42J cells". Journal of Cellular Biochemistry (2018): https://publons.com/publon/4142081/.
    10.1002/JCB.26280
  12. Antonio Martínez-Ruiz. "Identification of S-Nitrosylated and Reversibly Oxidized Proteins by Fluorescence Switch and Complementary Techniques.". Methods in molecular biology (Clifton, N.J.) (2018): https://publons.com/publon/19630180/.
    10.1007/978-1-4939-7695-9_7
  13. Antonio Martínez-Ruiz; Hugo M; Korovila I; Köhler M; García-García C; Cabrera-García JD; Marina A; Martínez-Ruiz A; Grune T. "Early cysteine-dependent inactivation of 26S proteasomes does not involve particle disassembly". Redox Biology (2018): https://publons.com/publon/19630181/.
    10.1016/J.REDOX.2018.02.016
  14. Jose Iglesiasa, Maria; Cecilia Terrile, Maria; Correa-Aragunde, Natalia; Lorena Colman, Silvana; Izquierdo-Alvarez, Alicia; Fernando Fiol, Diego; Paris, Ramiro; et al. "Regulation of SCFTIR1/AFBs E3 ligase assembly by S-nitrosylation of Arabidopsis SKP1-like1 impacts on auxin signaling". Redox Biology (2018): https://publons.com/publon/19320065/.
    10.1016/J.REDOX.2018.07.003
  15. Dolores Martin-de-Saavedra, Maria; Navarro, Elisa; Moreno-Ortega, Ana J.; Cunha, Mauricio P.; Buendia, Izaskun; Hernansanz-Agustin, Pablo; Leon, Rafael; et al. "The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation, and mitochondrial abnormalities". Journal of Neurochemistry (2018): https://publons.com/publon/4142083/.
    10.1111/JNC.14293
  16. Mendoza, Pilar; Martinez-Martin, Nuria; Bovolenta, Elena R.; Reyes-Garau, Diana; Hernansanz-Agustin, Pablo; Delgado, Pilar; Diaz-Munoz, Manuel D.; et al. "R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes". Science Signaling (2018): https://publons.com/publon/4142077/.
    10.1126/SCISIGNAL.AAL1506
  17. David Labrousse-Arias; Antonio Martínez-Ruiz; María J. Calzada. "Hypoxia and Redox Signaling on Extracellular Matrix Remodeling: From Mechanisms to Pathological Implications". Antioxidants & Redox Signaling (2017): https://publons.com/publon/4142086/.
    10.1089/ARS.2017.7275
  18. Hernansanz-Agustin, Pablo; Ramos, Elena; Navarro, Elisa; Parada, Esther; Sanchez-Lopez, Nuria; Pelaez-Aguado, Laura; Daniel Cabrera-Garcia, J.; et al. "yy Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia". Redox Biology (2017): https://publons.com/publon/4142048/.
    10.1016/J.REDOX.2017.04.025
  19. Ghashghaeinia, Mehrdad; Wesseling, Mauro Carlos; Ramos, Elena; Petkova-Kirova, Polina; Waibel, Sabrina; Lang, Elisabeth; Bissinger, Rosi; et al. "Trifluoperazine-Induced Suicidal Erythrocyte Death and S-Nitrosylation Inhibition, Reversed by the Nitric Oxide Donor Sodium Nitroprusside". Cellular Physiology and Biochemistry (2017): https://publons.com/publon/4142079/.
    10.1159/000479838
  20. Egea, Javier; Fabregat, Isabel; Frapart, Yves M.; Ghezzi, Pietro; Gorlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; et al. "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)". Redox Biology (2017): https://publons.com/publon/2063147/.
    10.1016/J.REDOX.2017.05.007
  21. García-Ortiz, A.; Martín-Cofreces, N.B.; Ibiza, S.; Ortega, Á.; Izquierdo-Álvarez, A.; Trullo, A.; Victor, V.M.; et al. "eNOS S-nitrosylates ß-actin on Cys374 and regulates PKC-¿ at the immune synapse by impairing actin binding to profilin-1". PLoS Biology 15 4 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019158746&partnerID=MN8TOARS.
    10.1371/journal.pbio.2000653
  22. Hernansanz-Agustín, P.; Ramos, E.; Navarro, E.; Parada, E.; Sánchez-López, N.; Peláez-Aguado, L.; Cabrera-García, J.D.; et al. "Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia". Redox Biology 12 (2017): 1040-1051. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019092634&partnerID=MN8TOARS.
    10.1016/j.redox.2017.04.025
  23. Patricia Santofimia-Castaño; Alicia Izquierdo-Alvarez; Irene de la Casa-Resino; Antonio Martinez-Ruiz; Marcos Perez-Lopez; Juan C. Portilla; Gines M. Salido; et al. "Ebselen alters cellular oxidative status and induces endoplasmic reticulum stress in rat hippocampal astrocytes". Toxicology (2016): https://publons.com/publon/1446843/.
    10.1016/j.tox.2016.06.002
  24. Bogdanova, A.; Petrushanko, I.Y.; Hernansanz-Agustín, P.; Martínez-Ruiz, A.; Bogdanova, Anna; Petrushanko, Irina Y.; Hernansanz-Agustin, Pablo; Martinez-Ruiz, Antonio. ""Oxygen sensing" by Na,K-ATPase: These miraculous thiols". Frontiers in Physiology 7 AUG (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988655549&partnerID=MN8TOARS.
    10.3389/fphys.2016.00314
  25. Soro-Arnaiz, Ines; Yang Li, Qilong Oscar; Torres-Capelli, Mar; Melendez-Rodriguez, Florinda; Veiga, Sonia; Veys, Koen; Sebastian, David; et al. "Role of Mitochondrial Complex IV in Age-Dependent Obesity". Cell Reports 16 11 (2016): 2991-3002. https://publons.com/publon/4142042/.
    10.1016/J.CELREP.2016.08.041
  26. Görlach, A.; Dimova, E.Y.; Petry, A.; Martínez-Ruiz, A.; Hernansanz-Agustín, P.; Rolo, A.P.; Palmeira, C.M.; et al. "Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?". Redox Biology 6 (2015): 372-385. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940472278&partnerID=MN8TOARS.
    10.1016/j.redox.2015.08.016
  27. Moreno, M.-L.; Escobar, J.; Finamor, I.; Martínez-Ruiz, A.; Sastre, J.. "Disulfide stress and its targets in acute pancreatitis". Inflammation and Allergy - Drug Targets 13 5 (2014): 312-322. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924101652&partnerID=MN8TOARS.
  28. Moreno, ML; Escobar, J; Izquierdo-Alvarez, A; Gil, A; Perez, S; Pereda, J; Zapico, I; et al. "Disulfide stress: a novel type of oxidative stress in acute pancreatitis". Free Radical Biology and Medicine 70 (2014): 265-277. https://publons.com/publon/2389208/.
    10.1016/j.freeradbiomed.2014.01.009
  29. Santos, A. I.; Martínez-Ruiz, A.; Araújo, I. M.; A I Santos; A Martínez-Ruiz; I M Araújo. "S-nitrosation and neuronal plasticity". Br J Pharmacol (2014): https://publons.com/publon/4142044/.
    10.1111/bph.12827
  30. Hernansanz-Agustin, Pablo; Izquierdo-Alvarez, Alicia; Sanchez-Gomez, Francisco J.; Ramos, Elena; Villa-Pina, Tamara; Lamas, Santiago; Bogdanova, Anna; et al. "Acute hypoxia produces a superoxide burst in cells". Free Radical Biology and Medicine 71 (2014): 146-156. https://publons.com/publon/4142033/.
    10.1016/J.FREERADBIOMED.2014.03.011
  31. Martinez-Ruiz, Antonio; Araujo, Ines M.; Izquierdo-Alvarez, Alicia; Hernansanz-Agustin, Pablo; Lamas, Santiago; Serrador, Juan M.. "Specificity in S-Nitrosylation: A Short-Range Mechanism for NO Signaling?". Antioxidants & Redox Signaling 19 11 (2013): 1220-1235. https://publons.com/publon/42697/.
    10.1089/ARS.2012.5066
  32. Hernansanz-Agustin, P.; Izquierdo-Alvarez, A.; Garcia-Ortiz, A.; Ibiza, S.; Serrador, J. M.; Martinez-Ruiz, A.; Hernansanz-Agustin, Pablo; et al. "Nitrosothiols in the Immune System: Signaling and Protection". Antioxidants & Redox Signaling 18 3 (2013): 288-308. https://publons.com/publon/4142026/.
    10.1089/ars.2012.4765
  33. Martínez-Acedo, P.; Núñez, E.; Sánchez Gómez, F.J.; Moreno, M.; Ramos, E.; Izquierdo-Álvarez, A.; Miró-Casas, E.; et al. "A novel strategy for global analysis of the dynamic thiol redox proteome". Molecular and Cellular Proteomics 11 9 (2012): 800-813. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865803473&partnerID=MN8TOARS.
    10.1074/mcp.M111.016469
  34. Izquierdo-Álvarez, A.; Ramos, E.; Villanueva, J.; Hernansanz-Agustín, P.; Fernández-Rodríguez, R.; Tello, D.; Carrascal, M.; et al. "Differential redox proteomics allows identification of proteins reversibly oxidized at cysteine residues in endothelial cells in response to acute hypoxia". Journal of Proteomics 75 17 (2012): 5449-5462. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865540710&partnerID=MN8TOARS.
    10.1016/j.jprot.2012.06.035
  35. Estefanía Núñez; Francisco J. Sánchez Gómez; Margoth Moreno; Elena Ramos; Alicia Izquierdo-Álvarez; Elisabet Miró-Casas; Raquel Mesa; et al. "A Novel Strategy for Global Analysis of the Dynamic Thiol Redox Proteome". Molecular & Cellular Proteomics (2012): https://publons.com/publon/4142036/.
    10.1074/MCP.M111.016469
  36. Martínez-Ruiz, A.; Cadenas, S.; Lamas, S.. "Erratum: Nitric oxide signaling: Classical, less classical, and nonclassical mechanisms (Free Radical Biology and Medicine (2011) 51 (17-29))". Free Radical Biology and Medicine 51 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79960015604&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2011.06.005
  37. Tello, Daniel; Balsa, Eduardo; Acosta-Iborra, Barbara; Fuertes-Yebra, Esther; Elorza, Ainara; Ordonez, Angel; Corral-Escariz, Maria; et al. "Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1 alpha Decreases Oxygen Consumption by Inhibiting Complex I Activity". Cell Metabolism 14 6 (2011): 768-779. https://publons.com/publon/4142023/.
    10.1016/J.CMET.2011.10.008
  38. Martinez-Ruiz, A.; Cadenas, S.; Lamas, S.; Antonio Martínez-Ruiz; Susana Cadenas; Santiago Lamas. "Nitric oxide signaling: Classical, less classical, and nonclassical mechanisms". Free Radical Biology and Medicine 51 1 (2011): 17-29. https://publons.com/publon/4142030/.
    10.1016/j.freeradbiomed.2011.04.010
  39. Leon-Bollotte, L.; Subramaniam, S.; Cauvard, O.; Plenchette-Colas, S.; Paul, C.; Godard, C.; Martinez-Ruiz, A.; et al. "S-Nitrosylation of the Death Receptor Fas Promotes Fas Ligand-Mediated Apoptosis in Cancer Cells". Gastroenterology 140 7 (2011): 2009-U242. https://publons.com/publon/4142027/.
    10.1053/j.gastro.2011.02.053
  40. Alicia Izquierdo-Álvarez; Antonio Martínez-Ruiz; Izquierdo-Alvarez, Alicia; Martinez-Ruiz, Antonio. "Thiol redox proteomics seen with fluorescent eyes: The detection of cysteine oxidative modifications by fluorescence derivatization and 2-DE". Journal of Proteomics 75 2 (2011): 329-338. https://publons.com/publon/4142024/.
    10.1016/J.JPROT.2011.09.013
  41. Gonzalez, Raul; Cruz, Adolfo; Ferrin, Gustavo; Lopez-Cillero, Pedro; Fernandez-Rodriguez, Ruben; Briceno, Javier; Gomez, Miguel A.; et al. "Nitric oxide mimics transcriptional and post-translational regulation during alpha-Tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes". Journal of Hepatology 55 1 (2011): 133-144. https://publons.com/publon/4142031/.
    10.1016/J.JHEP.2010.10.022
  42. Mariano Redondo-Horcajo; Natalia Romero; Pablo Martínez-Acedo; Celia Quijano; Catia F. Lourenço; Nieves Movilla; Jose Antonio Enríquez; et al. "Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide". Cardiovascular Research 87 2 (2010): 356-365. https://publons.com/publon/4142029/.
    10.1093/CVR/CVQ028
  43. Martínez-Ruiz, A.; Lamas, S.. "Two decades of new concepts in nitric oxide signaling: From the discovery of a gas messenger to the mediation of nonenzymatic posttranslational modifications". IUBMB Life 61 2 (2009): 91-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-63449139593&partnerID=MN8TOARS.
    10.1002/iub.144
  44. Tello, Daniel; Tarin, Carlos; Ahicart, Patricia; Breton-Romero, Rosa; Lamas, Santiago; Martinez-Ruiz, Antonio; Daniel Tello; et al. "A "fluorescence switch" technique increases the sensitivity of proteomic detection and identification of S-nitrosylated proteins". Proteomics 9 23 (2009): 5359-5370. https://publons.com/publon/4142028/.
    10.1002/pmic.200900070
  45. Antonio Martínez-Ruiz; Santiago Lamas. "Two Decades of New Concepts in Nitric Oxide Signaling: From the Discovery of a Gas Messenger to the Mediation of Nonenzymatic Posttranslational Modifications". IUBMB Life (2009): https://publons.com/publon/4142037/.
    10.1002/IUB.144
  46. Ibiza, S.; Pérez-Rodríguez, A.; Ortega, Á.; Martínez-Ruiz, A.; Barreiro, O.; García-Domínguez, C.A.; Víctor, V.M.; et al. "Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells". Proceedings of the National Academy of Sciences of the United States of America 105 30 (2008): 10507-10512. http://www.scopus.com/inward/record.url?eid=2-s2.0-48749099188&partnerID=MN8TOARS.
    10.1073/pnas.0711062105
  47. Rodríguez-Pascual, F.; Redondo-Horcajo, M.; Magán-Marchal, N.; Lagares, D.; Martínez-Ruiz, A.; Kleinert, H.; Lamas, S.. "Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability". Molecular and Cellular Biology 28 23 (2008): 7139-7155. http://www.scopus.com/inward/record.url?eid=2-s2.0-57349120623&partnerID=MN8TOARS.
    10.1128/MCB.01145-08
  48. Genís, L.; Gonzalo, P.; Tutor, A.S.; Gálvez, B.G.; Martínez-Ruiz, A.; Zaragoza, C.; Lamas, S.; et al. "Functional interplay between endothelial nitric oxide synthase and membrane type 1-matrix metalloproteinase in migrating endothelial cells". Blood 110 8 (2007): 2916-2923. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548935247&partnerID=MN8TOARS.
    10.1182/blood-2007-01-068080
  49. Martínez-Ruiz, A.; Lamas, S.; A MARTINEZRUIZ; S LAMAS. "Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: Convergences and divergences". Cardiovascular Research 75 2 (2007): 220-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250738347&partnerID=MN8TOARS.
    10.1016/j.cardiores.2007.03.016
  50. Martínez-Moreno, M.; Martínez-Ruiz, A.; Álvarez-Barrientos, A.; Gavilanes, F.; Lamas, S.; Rodríguez-Crespo, I.. "Nitric oxide down-regulates caveolin-3 levels through the interaction with myogenin, its transcription factor". Journal of Biological Chemistry 282 32 (2007): 23044-23054. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548157991&partnerID=MN8TOARS.
    10.1074/jbc.M610751200
  51. Mónica Martínez-Moreno; Alberto Álvarez-Barrientos; Francisco Gavilanes; Santiago Lamas; Ignacio Rodríguez-Crespo. "Nitric Oxide Down-regulates Caveolin-3 Levels through the Interaction with Myogenin, Its Transcription Factor". Journal of Biological Chemistry (2007): https://publons.com/publon/3804475/.
    10.1074/JBC.M610751200
  52. Inmaculada Jorge; Elisabet Miró Casas; Margarita Villar; Inmaculada Ortega-Pérez; Daniel López-Ferrer; Mónica Carrera; Anabel Marina; et al. "High-sensitivity analysis of specific peptides in complex samples by selected MS/MS ion monitoring and linear ion trap mass spectrometry: Application to biological studies". Journal of Mass Spectrometry 42 11 (2007): 1391-1403. https://publons.com/publon/4142034/.
    10.1002/JMS.1314
  53. Zaragoza, Carlos; Lopez-Rivera, Esther; Garcia-Rama, Concepcion; Saura, Marta; Martinez-Ruiz, Antonio; Lizarbe, Tania R.; Martin-de-Lara, Fernando; et al. "Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts". Journal of Cell Science 119 9 (2006): 1896-1902. https://publons.com/publon/4142046/.
    10.1242/JCS.02895
  54. Martínez-Ruiz, A.; Villanueva, L.; De Orduña, C.G.; López-Ferrer, D.; Ángeles Higueras, M.; Tarín, C.; Rodríguez-Crespo, I.; et al. "S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities". Proceedings of the National Academy of Sciences of the United States of America 102 24 (2005): 8525-8530. http://www.scopus.com/inward/record.url?eid=2-s2.0-20844444338&partnerID=MN8TOARS.
    10.1073/pnas.0407294102
  55. Martínez-Ruiz, A.; Lamas, S.. "Nitrosylation of thiols in vascular homeostasis and disease". Current Atherosclerosis Reports 7 3 (2005): 213-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444365814&partnerID=MN8TOARS.
  56. Lucía García-Ortega; Vivian De los Ríos; Antonio Martínez-Ruiz; Mercedes Oñaderra; Javier Lacadena; Álvaro Martínez del Pozo; José G. Gavilanes; et al. "Anomalous electrophoretic behavior of a very acidic protein: Ribonuclease U2". Electrophoresis 26 18 (2005): 3407-3413. https://publons.com/publon/4142047/.
    10.1002/ELPS.200500261
  57. Antonio Marti´nez-Ruiz; Santiago Lamas; Martínez-Ruiz, A.; Lamas, S.. "Detection and proteomic identification of S-nitrosylated proteins in endothelial cells". Archives of Biochemistry and Biophysics 423 1 (2004): 192-199. https://publons.com/publon/4142054/.
    10.1016/J.ABB.2003.12.006
  58. A Martínez-Ruiz; Martínez-Ruiz, A.; Lamas, S.. "S-nitrosylation: a potential new paradigm in signal transduction". Cardiovascular Research 62 1 (2004): 43-52. https://publons.com/publon/4142055/.
    10.1016/J.CARDIORES.2004.01.013
  59. Masip, M.; Lacadena, J.; Mancheño, J.M.; Oñaderra, M.; Martínez-Ruiz, A.; Del Pozo, A.M.; Gavilanes, J.G.; et al. "Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin". European Journal of Biochemistry 268 23 (2001): 6190-6196. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035207101&partnerID=MN8TOARS.
    10.1046/j.0014-2956.2001.02566.x
  60. Garcia-Ortega, L; Lacadena, J; Lacadena, V; Masip, M; de Antonio, C; Martinez-Ruiz, A; del Pozo, AM; et al. "The solubility of the ribotoxin alpha-sarcin, produced as a recombinant protein in Escherichia coli, is increased in the presence of thioredoxin". Letters in Applied Microbiology 30 4 (2000): 298-302. https://publons.com/publon/4142057/.
    10.1046/J.1472-765X.2000.00714.X
  61. de Antonio C; Martínez del Pozo A; Mancheño JM; Oñaderra M; Lacadena J; Pérez-Cañadillas JM; Bruix M; et al. "Assignment of the contribution of the tryptophan residues to the spectroscopic and functional properties of the ribotoxin alpha-sarcin". Proteins: Structure, Function, and Bioinformatics 41 3 (2000): 350-361. https://publons.com/publon/4142050/.
    10.1002/1097-0134(20001115)41:3<350::AID-PROT70>3.0.CO;2-V
  62. De Los Ríos, V.; Oñaderra, M.; Martínez-Ruiz, A.; Lacadena, J.; Mancheño, J.M.; Martínez Del Pozo, A.; Gavilanes, J.G.; et al. "Overproduction in Escherichia coli and purification of the hemolytic protein sticholysin II from the sea anemone Stichodactyla helianthus". Protein Expression and Purification 18 1 (2000): 71-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343340082&partnerID=MN8TOARS.
    10.1006/prep.1999.1174
  63. Martínez-Ruiz, A.; García-Ortega, L.; Kao, R.; Oñaderra, M.; Mancheño, J.M.; Davies, J.; Martínez Del Pozo, A.; Gavilanes, J.G.. "Ribonuclease U2: Cloning, production in Pichia pastoris and affinity chromatography purification of the active recombinant protein". FEMS Microbiology Letters 189 2 (2000): 165-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343953000&partnerID=MN8TOARS.
    10.1016/S0378-1097(00)00272-X
  64. Martínez-Ruiz, A.; Martínez Del Pozo, A.; Lacadena, J.; Oñaderra, M.; Gavilanes, J.G.; Antonio Martínez-Ruiz; Álvaro Martínez del Pozo; et al. "Hirsutellin A Displays Significant Homology to Microbial Extracellular Ribonucleases". Journal of Invertebrate Pathology 74 1 (1999): 96-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033161236&partnerID=MN8TOARS.
    10.1006/jipa.1999.4859
  65. Martínez-Ruiz, A.; Kao, R.; Davies, J.; Martínez del Pozo, A.. "Ribotoxins are a more widespread group of proteins within the filamentous fungi than previously believed". Toxicon 37 11 (1999): 1549-1563. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033231653&partnerID=MN8TOARS.
    10.1016/S0041-0101(99)00103-8
  66. Huecas, S.; Villalba, M.; González, E.; Martínez-Ruiz, A.; Rodríguez, R.; Sonia Huecas; Mayte Villalba; et al. "Production and detailed characterization of biologically active olive pollen allergen Ole e 1 secreted by the yeast Pichia pastoris". European Journal of Biochemistry 261 2 (1999): 539-545. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033561258&partnerID=MN8TOARS.
    10.1046/j.1432-1327.1999.00307.x
  67. Lacadena J; Martínez-Ruiz A; Pérez-Cañadillas JM; Bruix M; Mancheño JM; Oñaderra M; Gavilanes JG; et al. "Role of histidine-50, glutamic acid-96, and histidine-137 in the ribonucleolytic mechanism of the ribotoxin alpha-sarcin". Proteins: Structure, Function, and Bioinformatics 37 3 (1999): 474-484. https://publons.com/publon/4142065/.
    10.1002/(SICI)1097-0134(19991115)37:3<474::AID-PROT14>3.0.CO;2-N
  68. Martínez-Ruiz, A.; Del Pozo, A.M.; Lacadena, J.; Mancheño, J.M.; Oñaderra, M.; López-Otín, C.; Gavilanes, J.G.; et al. "Secretion of recombinant pro- and mature fungal a-sarcin ribotoxin by the methylotrophic yeast Pichia pastoris: The Lys-Arg motif is required for maturation". Protein Expression and Purification 12 3 (1998): 315-322. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032053012&partnerID=MN8TOARS.
    10.1006/prep.1997.0846
  69. Lacadena, J.; Martínez Del Pozo, A.; Lacadena, V.; Martínez-Ruiz, A.; Mancheño, J.M.; Oñaderra, M.; Gavilanes, J.G.. "The cytotoxin a-sarcin behaves as a cyclizing ribonuclease". FEBS Letters 424 1-2 (1998): 46-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032489354&partnerID=MN8TOARS.
    10.1016/S0014-5793(98)00137-9
  70. Jérémie Wirth; Alvaro Marti´nez del Pozo; José M. Mancheño; Antonio Marti´nez-Ruiz; Javier Lacadena; Mercedes Oñaderra; José G. Gavilanes; et al. "Sequence determination and molecular characterization of gigantin, a cytotoxic protein produced by the mould Aspergillus giganteus IFO 5818". Archives of Biochemistry and Biophysics 343 2 (1997): 188-193. https://publons.com/publon/4142061/.
    10.1006/ABBI.1997.0175
  71. Martínez-Ruiz, A.; Martínez Del Pozo, A.; Lacadena, J.; Mancheño, J.M.; Oñaderra, M.; Gavilanes, J.G.. "Characterization of a natural larger form of the antifungal protein (AFP) from Aspergillus giganteus". Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology 1340 1 (1997): 81-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343052593&partnerID=MN8TOARS.
    10.1016/S0167-4838(97)00038-1
  72. Lacadena, J; delPozo, AM; Gasset, M; Patino, B; CamposOlivas, R; Vazquez, C; MartinezRuiz, A; et al. "Characterization of the antifungal protein secreted by the mould Aspergillus giganteus". Archives of Biochemistry and Biophysics 324 2 (1995): 273-281. https://publons.com/publon/4142025/.
    10.1006/ABBI.1995.0040
  73. LACADENA, J; MANCHENO, JM; MARTINEZRUIZ, A; DELPOZO, AM; GASSET, M; ONADERRA, M; GAVILANES, JG. "SUBSTITUTION OF HISTIDINE-137 BY GLUTAMINE ABOLISHES THE CATALYTIC ACTIVITY OF THE RIBOSOME-INACTIVATING PROTEIN ALPHA-SARCIN". Biochemical Journal (1995): https://publons.com/publon/4142058/.
    10.1042/BJ3090581
  74. Lacadena, J.; Mancheno, J.M.; Martinez-Ruiz, A.; Martinez del Pozo, A.; Gasset, M.; Onaderra, M.; Gavilanes, J.G.. "Substitution of histidine-137 by glutamine abolishes the catalytic activity of the ribosome-inactivating protein a-sarcin". Biochemical Journal 309 2 (1995): 581-586. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029006339&partnerID=MN8TOARS.
Capítulo de livro
  1. Hernansanz-Agustín, Pablo; Choya-Foces, Carmen; Martínez-Ruiz, Antonio. "Measurement of Superoxide Production in Acute Hypoxia by Fixed-Cell Microscopy". In Methods in Molecular Biology, 43-50. Springer US, 2020.
    Publicado • 10.1007/978-1-0716-0896-8_3
Livro
  1. Martínez-Ruiz, A.; Lamas, S.. Proteomic identification of 5-nitrosylated proteins in endothelial cells. 2007.
    10.1385/1-59745-214-9:215
  2. Martínez-Ruiz, A.; Lamas, S.. Detection and identification of S-nitrosylated proteins in endothelial cells. 2005.
    10.1016/S0076-6879(05)96013-8
  3. Martínez-Ruiz, A.; García-Ortega, L.; Kao, R.; Lacadena, J.; Oñaderra, M.; Mancheño, J.M.; Davies, J.; Martínez del Pozo, A.; Gavilanes, J.G.. RNase U2 and a-sarcin: A study of relationships. 2001.
    10.1016/S0076-6879(01)41162-1
  4. Kao, R.; Martínez-Ruiz, A.; Del Pozo, A.M.; Crameri, R.; Davies, J.. Mitogillin and related fungal ribotoxins. 2001.
    10.1016/S0076-6879(01)41161-X
Distinções

Prémio

2015 Catherine Pasquier Award to the research career
Society for Free Radical Research - Europe (SFRR-E), Reino Unido
1996 Primer Premio Nacional de terminación de estudios en Química / 1st National Prize of Bachelor Degree in Chemistry
Ministerio de Educación y Ciencia, Gobierno de España, Espanha
1995 Premio Extraordinario de Licenciatura / Extraordinary Award of Bachelor Degree in Chemistry
Universidad Complutense de Madrid, Espanha