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Identificação

Identificação pessoal

Nome completo
Susana Margarida Neto Simões

Identificadores de autor

Ciência ID
C81A-1A9D-C712
Produções

Publicações

Artigo em revista
  1. Mendes, Maria; Sereno, José; Ramos, Maria Luísa; Fortuna, Ana; Oliveira, Rui; Simões, Susana; Ferreira, Lino; et al. "Dual-targeted hyaluronic acid conjugates on lipid nanoparticles improve delivery and efficacy against glioblastoma: The linkage leads the fate". International Journal of Biological Macromolecules 332 (2025): 148404. https://doi.org/10.1016/j.ijbiomac.2025.148404.
    10.1016/j.ijbiomac.2025.148404
  2. Heloísa Gerardo; Tânia Lourenço; Júlio Torres; Manuela Ferreira; Célia Aveleira; Susana Simões; Lino Ferreira; et al. "Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux". European Journal of Clinical Investigation (2025):
    Aceite para publicação
  3. Francesca Tomatis; Susana Rosa; Susana Simões; Marta Barão; Carlos Jesus; João Novo; Emanuel Barth; Manja Marz; Lino Ferreira. "Engineering extracellular vesicles to transiently permeabilize the blood–brain barrier". Journal of Nanobiotechnology (2024): https://doi.org/10.1186/s12951-024-03019-w.
    10.1186/s12951-024-03019-w
  4. Tomatis, Francesca; Susana Rosa; Simões, Susana; Marta Barão; Carlos Jesus; João Novo; Emanuel Barth; Manja Marz; Lino Ferreira. "Engineering extracellular vesicles to transiently permeabilize the blood-brain barrier". Journal of Nanobiotechnology (2024): https://doi.org/10.1186/s12951-024-03019-w.
    Acesso aberto • Aceite para publicação
  5. Ana Rita Sousa; Ana F. Cunha; Ana Santos-Coquillat; Beatriz Hernaez Estrada; Kara L. Spiller; Marta Barão; Artur Filipe Rodrigues; et al. "Shape-Versatile Fixed Cellular Materials for Multiple Target Immunomodulation". Advanced Materials (2024): http://dx.doi.org/10.1002/adma.202405367.
    10.1002/adma.202405367
  6. Simões, Susana; Lino, Miguel; Barrera, Angela; Rebelo, Catarina; Tomatis, Francesca; Vilaça, Andreia; Breunig, Christopher; et al. Autor correspondente: Simões, Susana. "Near-Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR-Cas9 Ribonucleoprotein for Brain Gene Editing". Angewandte Chemie International Edition 63 21 (2024): http://dx.doi.org/10.1002/anie.202401004.
    10.1002/anie.202401004
  7. González, Ricardo D.; Simões, Susana; Ferreira, Lino; Carvalho, Alexandra T. P.. "Designing Cell Delivery Peptides and SARS-CoV-2-Targeting Small Interfering RNAs: A Comprehensive Bioinformatics Study with Generative Adversarial Network-Based Peptide Design and In Vitro Assays". Molecular Pharmaceutics 20 12 (2023): 6079-6089. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00444.
    10.1021/acs.molpharmaceut.3c00444
  8. Artur Filipe Rodrigues; Ana P. M. Tavares; Susana Simões; Rui P. F. F. Silva; Tomás Sobrino; Bruno R. Figueiredo; Goreti Sales; Lino Ferreira. "Engineering graphene-based electrodes for optical neural stimulation". Nanoscale (2023): https://doi.org/10.1039/D2NR05256C.
    10.1039/D2NR05256C
  9. Artur Filipe Rodrigues; Catarina Rebelo; Tiago Reis; Susana Simões; Liliana Bernardino; João Peça; Lino Ferreira. "Engineering optical tools for remotely controlled brain stimulation and regeneration". Biomaterials Science (2023): https://doi.org/10.1039/D2BM02059A.
    10.1039/D2BM02059A
  10. Artur Filipe Rodrigues; Catarina Rebelo; Susana Simões; Cristiana Paulo; Sónia Pinho; Vítor Francisco; Lino Ferreira. "A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts". Advanced Science (2022): https://doi.org/10.1002/advs.202205475.
    10.1002/advs.202205475
  11. Catarina Rebelo; Tiago Reis; Guedes, JR; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al. "Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-31791-6.
    10.1038/s41467-022-31791-6
  12. Miguel M. Lino; Simões, Susana; Francesca Tomatis; Inês Albino; Angela Barrera; Denis Vivien; Tomás Sobrino; Lino Ferreira. "Engineered extracellular vesicles as brain therapeutics". Journal of Controlled Release 338 (2021): 472-485. http://dx.doi.org/10.1016/j.jconrel.2021.08.037.
    10.1016/j.jconrel.2021.08.037
  13. Sara Bernardo-Castro; Inês Albino; Angela Barrera; Francesca Tomatis; Sousa, João André; Emanuel Martins; Simões, Susana; et al. "Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke". Life 11 6 (2021): 482-482. http://dx.doi.org/10.3390/life11060482.
    10.3390/life11060482
  14. João Conniot; Sepehr Talebian; Susana Simões; Lino Ferreira; João Conde. "Revisiting gene delivery to the brain: silencing and editing". Biomaterials Science 9 4 (2021): 1065-1087. https://doi.org/10.1039/D0BM01278E.
    10.1039/D0BM01278E
  15. Josephine Blersch; Vitor Francisco; Catarina Rebelo; Adrian Jiménez-Balsa; Helena Antunes; Sandra Pinto; Susana Simões; Akhilesh Rai; Lino Ferreira. "A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1a (HIF-1a)". Nanoscale (2020): https://doi.org/10.1039/C9NR10503D.
    10.1039/C9NR10503D
  16. Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Gonzato, Carlo; Pinto, Sandra; et al. "A Light-Triggerable Nanoparticle Library for the Controlled Release of Non-Coding RNAs". Angewandte Chemie International Edition 59 5 (2019): 1985-1991. http://dx.doi.org/10.1002/anie.201911398.
    10.1002/anie.201911398
  17. Lino, Miguel M.; Simões, Susana; Vilaça, Andreia; Antunes, Helena; Zonari, Alessandra; Ferreira, Lino. "Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers". ACS Nano 12 6 (2018): 5207-5220. http://dx.doi.org/10.1021/acsnano.7b07538.
    10.1021/acsnano.7b07538
  18. Lopes M; Aniceto D; Abrantes M; Simões S; Branco F; Vitória I; Botelho MF; et al. "In vivo biodistribution of antihyperglycemic biopolymer-based nanoparticles for the treatment of type 1 and type 2 diabetes.". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V (2017): http://europepmc.org/abstract/med/28007370.
    10.1016/j.ejpb.2016.11.037
  19. Miguel M. Lino; Susana Simões; Sónia Pinho; Lino Ferreira. "Intracellular delivery of more than one protein with spatio-temporal control". Nanoscale 9 47 (2017): 18668-18680. http://dx.doi.org/10.1039/c7nr02414b.
    10.1039/c7nr02414b
  20. del Rosario, C.; Rodríguez-Évora, M.; Reyes, R.; Simões, S.; Concheiro, A.; Évora, C.; Alvarez-Lorenzo, C.; Delgado, A.. "Bone critical defect repair with poloxamine–cyclodextrin supramolecular gels". International Journal of Pharmaceutics 495 1 (2015): 463-473. http://dx.doi.org/10.1016/j.ijpharm.2015.09.003.
    10.1016/j.ijpharm.2015.09.003
  21. Lopes, Marlene; Simões, Susana; Veiga, Francisco; Seiça, Raquel; Ribeiro, António. "Why most oral insulin formulations do not reach clinical trials.". Therapeutic Delivery 6 8 (2015): 973-987. http://europepmc.org/abstract/med/26272222.
    10.4155/TDE.15.47
  22. Figueiras, Ana; Nunes, Sandra C. C.; Simões, Susana; Pais, Alberto A. C. C.; Veiga, Francisco. "Molecular interaction governing solubility and release profiles in supramolecular systems containing fenbufen, pluronics and cyclodextrins". Journal of Inclusion Phenomena and Macrocyclic Chemistry 81 3-4 (2015): 395-407. http://dx.doi.org/10.1007/s10847-014-0466-7.
    10.1007/s10847-014-0466-7
  23. Simões, Susana M. N.; Rey-Rico, Ana; Concheiro, Angel; Alvarez-Lorenzo, Carmen. "Supramolecular cyclodextrin-based drug nanocarriers". Chemical Communications 51 29 (2015): 6275-6289. http://dx.doi.org/10.1039/c4cc10388b.
    10.1039/c4cc10388b
  24. Simões, Susana MN; Figueiras, Ana R; Veiga, Francisco; Concheiro, Angel; Alvarez-Lorenzo, Carmen. "Polymeric micelles for oral drug administration enabling locoregional and systemic treatments". Expert Opinion on Drug Delivery 12 2 (2014): 297-318. http://dx.doi.org/10.1517/17425247.2015.960841.
    10.1517/17425247.2015.960841
  25. Simões SM; Veiga F; Ribeiro AC; Figueiras AR; Taboada P; Concheiro A; Alvarez-Lorenzo C; et al. "Supramolecular gels of poly-a-cyclodextrin and PEO-based copolymers for controlled drug release.". (2014): http://europepmc.org/abstract/med/24769064.
    10.1016/j.ejpb.2014.04.006
  26. Simões SM; Veiga F; Torres-Labandeira JJ; Ribeiro AC; Concheiro A; Alvarez-Lorenzo C. "Syringeable self-assembled cyclodextrin gels for drug delivery.". (2014): http://europepmc.org/abstract/med/24354670.
    10.2174/1568026613666131219124308
  27. Simões SM; Veiga F; Torres-Labandeira JJ; Ribeiro AC; Concheiro A; Alvarez-Lorenzo C. "Poloxamine-cyclodextrin-simvastatin supramolecular systems promote osteoblast differentiation of mesenchymal stem cells.". (2013): http://europepmc.org/abstract/med/23610048.
    10.1002/mabi.201300017
  28. Simões, Susana. "Modular hydrogels for drug delivery". Journal of Biomaterials and Nanobiotechnology (2012): http://www.scirp.org/journal/PaperInformation.aspx?PaperID=18938#.VCm8O2ddWE0.
    10.4236/jbnb.2012.32025
  29. Simões SM; Veiga F; Torres-Labandeira JJ; Ribeiro AC; Sandez-Macho MI; Concheiro A; Alvarez-Lorenzo C. "Syringeable Pluronic-a-cyclodextrin supramolecular gels for sustained delivery of vancomycin.". (2012): http://europepmc.org/abstract/med/22005155.
    10.1016/j.ejpb.2011.09.017
  30. Figueiras, A.; Vieira, A.; Simões, S.; Veiga, F.. "Mucoadhesive buccal systems as a novel strategy for anti-inflammatory drugs administration". Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry 10 3 (2011): 190-202. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960610965&partnerID=MN8TOARS.
  31. Ribeiro, A.C.F.; Sobral, A.J.F.N.; Simões, S.M.N.; Barros, M.C.F.; Lobo, V.M.M.; Cabral, A.M.T.D.P.V.; Veiga, F.J.B.; Santos, C.I.A.V.; Esteso, M.A.. "Transport properties of aqueous solutions of sodium alginate at 298.15K". Food Chemistry 125 4 (2011): 1213-1218. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649326117&partnerID=MN8TOARS.
    10.1016/j.foodchem.2010.10.036
  32. Ribeiro, A.C.F.; Valente, A.J.M.; Costa, D.O.; Simões, S.M.N.; Pereira, R.F.P.; Lobo, V.M.M.; Esteso, M.A.. "Interactions of cobalt chloride with saccharose in aqueous solutions at 298.15 K". Electrochimica Acta 55 15 (2010): 4483-4487. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950866087&partnerID=MN8TOARS.
    10.1016/j.electacta.2010.02.090
  33. Fernandes, D.M.; Simões, S.M.N.; Carapuça, H.M.; Brett, C.M.A.; Cavaleiro, A.M.V.. "Novel poly(hexylmethacrylate) composite carbon electrodes modified with Keggin-type tungstophosphate-tetrabutylammonium salts". Journal of Electroanalytical Chemistry 639 1-2 (2010): 83-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249095252&partnerID=MN8TOARS.
    10.1016/j.jelechem.2009.11.020
  34. Ribeiro, A.C.F.; Simões, S.M.N.; Lobo, V.M.M.; Valente, A.J.M.; Esteso, M.A.. "Interaction between copper chloride and caffeine as seen by diffusion at 25 °C and 37 °C". Food Chemistry 118 3 (2010): 847-850. http://www.scopus.com/inward/record.url?eid=2-s2.0-69349095354&partnerID=MN8TOARS.
    10.1016/j.foodchem.2009.05.026
  35. Ribeiro, A.C.F.; Simões, S.M.N.; Lobo, V.M.M.; Cabral, A.M.T.D.P.V.; Veiga, F.J.B.; Esteso, M.A.. "Diffusion coefficients of (copper chloride + theophylline + water) at temperatures of (298 and 310) K". Journal of Chemical and Engineering Data 55 6 (2010): 2192-2194. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953505060&partnerID=MN8TOARS.
    10.1021/je900762k
  36. Fernandes, D.M.; Simöes, S.M.N.; Carapuça, H.M.; Cavaleiro, A.M.V.. "Functionalisation of glassy carbon electrodes with deposited tetrabutylammonium microcrystalline salts of lacunary and metal-substituted a-Keggin-polyoxosilicotungstates". Electrochimica Acta 53 22 (2008): 6580-6588. http://www.scopus.com/inward/record.url?eid=2-s2.0-54249164527&partnerID=MN8TOARS.
    10.1016/j.electacta.2008.04.071
  37. Ribeiro, A.C.F.; Esteso, M.A.; Lobo, V.M.M.; Valente, A.J.M.; Simões, S.M.N.; Sobral, A.J.F.N.; Burrows, H.D.. "Interactions of copper (II) chloride with sucrose, glucose, and fructose in aqueous solutions". Journal of Molecular Structure 826 2-3 (2007): 113-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846161972&partnerID=MN8TOARS.
    10.1016/j.molstruc.2006.04.035
  38. Ribeiro, A.C.F.; Lobo, V.M.M.; Valente, A.J.M.; Simões, S.M.N.; Sobral, A.J.F.N.; Ramos, M.L.; Burrows, H.D.. "Association between ammonium monovanadate and ß-cyclodextrin as seen by NMR and transport techniques". Polyhedron 25 18 (2006): 3581-3587. http://www.scopus.com/inward/record.url?eid=2-s2.0-37849187864&partnerID=MN8TOARS.
    10.1016/j.poly.2006.07.006
  39. Ribeiro, A.C.F.; Ortona, O.; Simões, S.M.N.; Santos, C.I.A.V.; Prazeres, P.M.R.A.; Valente, A.J.M.; Lobo, V.M.M.; Burrows, H.D.. "Binary mutual diffusion coefficients of aqueous solutions of sucrose, lactose, glucose, and fructose in the temperature range from (298.15 to 328.15) K". Journal of Chemical and Engineering Data 51 5 (2006): 1836-1840. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749999993&partnerID=MN8TOARS.
    10.1021/je0602061
  40. Ribeiro, A.; Esteso, M.; Lobo, V.; Valente, A.; Simões, S.; Sobral, A.; Ramos, L.; et al. "Interactions of copper (II) chloride with ß-cyclodextrin in aqueous solutions". Journal of Carbohydrate Chemistry 25 2-3 (2006): 173-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745116225&partnerID=MN8TOARS.
    10.1080/07328300600732469
  41. Ribeiro, A.C.F.; Esteso, M.A.; Lobo, V.M.M.; Valente, A.J.M.; Simoes, S.M.N.; Sobral, A.J.F.N.; Burrows, H.D.. "Diffusion coefficients of copper chloride in aqueous solutions at 298.15 K and 310.15 K". Journal of Chemical and Engineering Data 50 6 (2005): 1986-1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-28644437148&partnerID=MN8TOARS.
    10.1021/je050220y
Artigo em revista (magazine)
  1. Simões, Susana; Fernandes, Hugo; Ferreira, Lino. Autor correspondente: Simões, Susana. "Recent advances on nonviral CRISPR nanoformulations for brain delivery and clinicalapproaches", ARRIGE (Association for Responsible Research and Innovation in Genome Editing), 2021, https://www.arrige.org/wp-content/uploads/2021/11/ARRIGE_newsletter4.pdf.
Capítulo de livro
  1. Simões, Susana. "In situ Administration: Simvastatin in Bone Regeneration". 2015.
Poster em conferência
  1. Tomatis, Francesca; Simões, Susana; Rosa, Susana; Emanuel Barth; Marz, Manja; Ferreira, Lino. "Engineering extracellular vesicles to cross the blood-brain barrier". Trabalho apresentado em FENS Regional Meeting, 2023.
  2. Francisco, Vitor; Rodrigues, Artur Filipe; Rebelo, Catarina; Paulo, Cristiana; Rita Pereira; Simões, Susana; Pinho, Sonia L. C:; Ferreira, Lino. Autor correspondente: Francisco, Vitor. "A nano formulation for targeted mRNA delivery to tackle fibrotic diseases". Trabalho apresentado em Ageing Without Borders, 2022.
  3. Tomatis, Francesca; Simões, Susana; Susana Rosa; Emanuel Barth; Marz, Manja; Ferreira, Lino. "Engineering extracellular vesicles with microRNAs to cross the blood-brain barrier". Trabalho apresentado em 2nd RESETageing conference, 2022.
  4. Simões, Susana; Angela Barrera Sandoval; Lino, Miguel; Rebelo, Catarina; Tomatis, Francesca; Andrea Neuner; Stefan Stricker; Ferreira, Lino. "Non-viral gene editing system for brain delivery with spatio control". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  5. Simões, Susana; Miguel M. Lino; Francesca Tomatis; Christopher Breunig; Stefan Stricker; Lino Ferreira. "A light-activatable formulation for the controlled release of CRISPR-Cas9 system". Trabalho apresentado em Controlled Release Society Annual Meeting & Exposition, 2019.
  6. Simões, Susana; Miguel M. Lino; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira. "Near-infrared triggered release of miRNAs for modulation of cell activity". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  7. Simões, Susana; Miguel M. Lino; Sonia Pinho; Lino Ferreira. "Light-triggered intracellular delivery of proteins with spatio-temporal control". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017.
  8. Simões, Susana; Lino, Miguel; Pinho, Sonia; Ferreira, Lino. "Light-controlled release of proteins from gold nanorods". Trabalho apresentado em 3rd Symposium in Nanoscience and Biomedical Nanotechnology, 2016.
  9. Simões, Susana; Francisco Veiga; Carmen Alvarez-Lorenzo; Angel Concheiro. "Supramolecular alpha-cyclodextrin/PEO-copolymers for osteomyelitis and bone regeneration". Trabalho apresentado em 17th International Cyclodextrin Symposium, 2014.
  10. Simões, Susana; Francisco Veiga; Carmen Alvarez-Lorenzo; Angel Concheiro; Ana Figueiras. "Micelles supramolecular assemblies of Pluronic® and methyl-ß-cyclodextrin for drug release". Trabalho apresentado em 17th International Cyclodextrin Symposium, 2014.
  11. Simões, Susana; Ana Miranda; Maria João Garcia; Francisco Veiga; Ana Figueiras. "Synergistic encapsulation of fenbufen using Pluronic®-cyclodextrin micellar systems". Trabalho apresentado em 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014.
  12. Simões, Susana; Francisco Veiga; Ana Ribeiro; Juan Torres-Labandeira; Carmen Alvarez-Lorenzo. "Syringeable implantes of pluronic-a-cyclodextrin gels for controlled relase of antimicrobial agents". Trabalho apresentado em 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2012.
  13. Simões, Susana; Francisco Veiga; Juan Torres-Labandeira; Angel Concheiro; Carmen Alvarez-Lorenzo. "Supramolecular hydrogels of Pluronic-a-cyclodextrin for controlled release of Vancomycin". Trabalho apresentado em AAPS Annual Meeting, Washington DC, 2011.
    10.19146/pibic-2016-51248
Pré-impressão
  1. Maria Mendes; José Sereno; Maria Luísa Ramos; Ana Fortuna; Rui Caetano; Susana Simões; Lino Ferreira; et al. "Surface Matters: How to Incorporate Conjugates in Lipid Nanoparticles Fighting Glioblastoma". 2025. http://dx.doi.org/10.2139/ssrn.5128610.
    10.2139/ssrn.5128610

Propriedade Intelectual

Patente
  1. Simões, Susana; Lino Ferreira. 2024. "Polynucleotide construct comprising the CRISPR-Cas9 ribonucleoprotein complex". Portugal.
  2. Simões, Susana. 2014. "Poloxamine hydrogels and the use thereof for bone regeneration or repair".
    Expirada