LUÍS MIGUEL BEICINHA BRANCO ESTRONCA (B914-E58A-F196)

Curriculum Vitae

LUÍS MIGUEL BEICINHA BRANCO ESTRONCA

Luís Estronca is a researcher with a robust background at the interface of Biological Chemistry and Biomedical Engineering. His research focuses on the molecular mechanisms of aging and the development of high-fidelity in vitro platforms to study cardiovascular and neurodegenerative diseases. Dr. Estronca possesses advanced experience using microfluidic devices to mimetically recreate the vascular microenvironment. Through his work at the Advanced Therapies Group (CIBB/CNC-UC), he has specialized in the differentiation of induced Pluripotent Stem Cells (iPSCs) into different types of vascular cells which enables the creation of patient-specific vascular cell models, essential for investigating how genetic predisposition and cellular senescence influence blood-brain barrier (BBB) integrity and the inflammatory response following an ischemic event. With extensive experience in aging-focused european projects (e.g., RESETageing, CHAngeing), his work focuses on the molecular characterization of cellular senescence markers and the inflammatory profile of the SASP.

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Identificação

Identificação pessoal

Nome completo: LUÍS MIGUEL BEICINHA BRANCO ESTRONCA

Nomes de citação

Estronca, Luís
Estronca, LMBB
Estronca, LM

Identificadores de autor

Ciência ID: B914-E58A-F196
ORCID iD: 0000-0001-8417-8313

Moradas

Biocant Park, Edificio UC-Biotech, Núcleo 4, Lote 8 , 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

https://colab4ageing.pt/ (Profissional)

Domínios de atuação

Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
Ciências Naturais - Ciências Biológicas - Biologia Celular
Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Projetos

Projeto

	Designação	Financiadores
2024/05 - Atual	CHANGEING – Excellence Hubs - Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function Grant Agreement: 101087071 Investigador Universidade de Coimbra, Portugal	Em curso
2024/03 - Atual	REGENERAR - Improving the effectiveness and safety of epigenetic regeneration Grant Agreement no. 101129812 Outra Universidade de Coimbra, Portugal	Em curso
2023/03/01 - 2026/02/28	Targeted anti-senescence formulations 2022.07615.PTDC Investigador Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/03/01 - 2024/08/31	A therapeutic strategy to fight blood-brain-barrier (BBB) ageing PTDC/BTM-SAL/5174/2020 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/05/20 - 2024/05	RESEarch for healThy AGEING - RESETageing Grant agreement ID: 952266 Investigador Universidade de Coimbra, Portugal	EU Framework Programme for Research and Innovation Euratom Em curso
2021/11/01 - 2023/11/30	Preservation of natural and cultural heritage and scientific validation of practices with medicinal plants from Côa Valley COA/BRB/0019/2019 Investigador Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020/11 - 2022/10	COVIRNA - A diagnostic test to improve surveillance and care of COVID-19 patients Grant agreement ID: 101016072 Investigador	EU Framework Programme for Research and Innovation Science with and for Society Em curso
2018/07/26 - 2022/05/25	An iPSC-derived vascular model of Progeria to identify mediators for smooth muscle loss PTDC/BTM-SAL/29229/2017 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07/06 - 2022/05/05	A light-activatable nanoparticle library for the delivery of RNA-based therapies PTDC/EQU-EQU/29414/2017 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2016/11/17 - 2021/03/31	Era@UC - Enhancing Research in Ageing at The University of Coimbra GA 669088 ERAatUC Investigador Universidade de Coimbra, Portugal	EU Framework Programme for Research and Innovation Euratom Concluído
2012/05/01 - 2015/09/30	Personalized 3D vascular constructs for toxicity assessment- VASCTOX PTDC/SAU-TOX/121887/2010 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2013/12/31	A sistematic functional analysis for Rab proteins in phagocytosis and phagosomal maturation of Mycobacterium tuberculosis PTDC/BIA-BCM/112138/2009 Investigador	Concluído
2008/06/01 - 2010/08/31	ROLE AND MOLECULAR MECHANISMS UNDERLYING CD36-MEDIATED PHAGOCYTOSIS OF APOPTOTIC CELLS: IMPLICATIONS FOR ATHEROSCLEROSIS PTDC/SAU-MII/66285/2006 Investigador	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista

Santinha, Deolinda; Vilaça, Andreia; Estronca, Luís; Schüler, Svenja C.; Bartoli, Catherine; De Sandre-Giovannoli, Annachiara; Figueiredo, Arnaldo; et al. "Remodelling of the cardiac extracellular matrix proteome during chronological and pathological ageing". Molecular & Cellular Proteomics (2023): 100706. http://dx.doi.org/10.1016/j.mcpro.2023.100706.
Publicado • 10.1016/j.mcpro.2023.100706
Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al. "Induced pluripotent stem cell-derived vascular networks to screen nano-bio interactions". Nanoscale Horizons (2021): http://dx.doi.org/10.1039/d0nh00550a.
10.1039/d0nh00550a
Pitrez, Patricia R.; Estronca, Luís; Monteiro, Luís Miguel; Colell, Guillem; Vazão, Helena; Santinha, Deolinda; Harhouri, Karim; et al. "Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-17901-2.
10.1038/s41467-020-17901-2
Pitrez, Patricia R.; Estronca, Luís; Vazão, Helena; Egesipe, Anne-Laure; Le Corf, Amélie; Navarro, Claire; Lévy, Nicolas; et al. "Substrate Topography Modulates Cell Aging on a Progeria Cell Model". ACS Biomaterials Science & Engineering 4 5 (2018): 1498-1504. http://dx.doi.org/10.1021/acsbiomaterials.8b00224.
10.1021/acsbiomaterials.8b00224
Domingues, N.; Estronca, L.M.B.B.; Silva, J.; Encarnação, M.R.; Mateus, R.; Silva, D.; Santarino, I.B.; et al. "Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1862 2 (2017): 210-220. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999089924&partnerID=MN8TOARS.
10.1016/j.bbalip.2016.10.009
Inácio, Â.S.; Domingues, N.S.; Nunes, A.; Martins, P.T.; Moreno, M.J.; Estronca, L.M.; Fernandes, R.; et al. "Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: Mechanisms of action and clinical implications in antibacterial prophylaxis". Journal of Antimicrobial Chemotherapy 71 3 (2016): 641-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960839711&partnerID=MN8TOARS.
10.1093/jac/dkv405
Estronca, L.M.B.B.; Filipe, H.A.L.; Salvador, A.; Moreno, M.J.; Vaz, W.L.C.. "Homeostasis of free cholesterol in the blood: A preliminary evaluation and modeling of its passive transport". Journal of Lipid Research 55 6 (2014): 1033-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660412&partnerID=MN8TOARS.
10.1194/jlr.M043067
Viegas, M.S.; Estronca, L.M.B.B.; Vieira, O.V.. "Comparison of the Kinetics of Maturation of Phagosomes Containing Apoptotic Cells and IgG-Opsonized Particles". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84868316815&partnerID=MN8TOARS.
10.1371/journal.pone.0048391
Estronca, L.M.B.B.; Silva, J.C.P.; Sampaio, J.L.; Shevchenko, A.; Verkade, P.; Vaz, A.D.N.; Vaz, W.L.C.; Vieira, O.V.. "Molecular etiology of atherogenesis - in vitro induction of lipidosis in macrophages with a new LDL model". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859710740&partnerID=MN8TOARS.
10.1371/journal.pone.0034822
Estronca, Luís M.B.B.; Moreno, Maria João; Vaz, Winchil L.C.. "Kinetics and Thermodynamics of the Association of Dehydroergosterol with Lipid Bilayer Membranes". Biophysical Journal 93 12 (2007): 4244-4253. http://dx.doi.org/10.1529/biophysj.107.112847.
10.1529/biophysj.107.112847
Moreno, M.J.; Estronca, L.M.B.B.; Vaz, W.L.C.. "Translocation of phospholipids and dithionite permeability in liquid-ordered and liquid-disordered membranes". Biophysical Journal 91 3 (2006): 873-881. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746714404&partnerID=MN8TOARS.
10.1529/biophysj.106.082115
Estronca, L.M.B.B.; Moreno, M.J.; Laranjinha, J.A.N.; Almeida, L.M.; Vaz, W.L.C.. "Kinetics and thermodynamics of lipid amphiphile exchange between lipoproteins and albumin in serum". Biophysical Journal 88 1 (2005): 557-565. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244253621&partnerID=MN8TOARS.
10.1529/biophysj.104.047050
Abreu, M.S.C.; Estronca, L.M.B.B.; Moreno, M.J.; Vaz, W.L.C.. "Binding of a fluorescent lipid amphiphile to albumin and its transfer to lipid bilayer membranes". Biophysical Journal 84 1 (2003): 386-399. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037216785&partnerID=MN8TOARS.
Estronca, L.M.B.B.; João Moreno, M.; Abreu, M.S.C.; Melo, E.; Vaz, W.L.C.. "Solubility of amphiphiles in membranes: Influence of phase properties and amphiphile head group". Biochemical and Biophysical Research Communications 296 3 (2002): 596-603. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036384222&partnerID=MN8TOARS.
10.1016/S0006-291X(02)00905-1

Capítulo de livro

Estronca, L.; Ferreira, L.. "Stem Cells for the Regeneration of Chronic Wounds: A Translational Perspective". 2016.
10.1016/B978-0-444-63265-4.00013-3