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John Griffith Jones is currently a Senior Researcher in the Center of Neurosciences at the University of Coimbra, Portugal. His longstanding research focus has been the use of stable isotopes and NMR spectroscopy to study metabolic fluxes in different organisms, ranging from yeast to humans. He completed his Ph.D. at the University of Texas at Arlington under the supervision of Dr Edward Bellion, where he applied 13C- and 15N-enriched stable isotope tracers and NMR spectroscopy to study metabolic fluxes in methylotrophic yeast. He then moved to the Lab of Craig Malloy and Dean Sherry at the Department of Radiology at U.T. Southwestern Medical Center in Dallas where he initially studied Krebs cycle fluxes in isolated perfused hearts using the 13C NMR isotopomer analyses and modeling methods that was being developed by this group. He became interested in hepatic Krebs cycle metabolism and contributed to the modeling of futile pyruvate cycling by 13C isotopomer analysis and integrating Krebs cycle flux information with gluconeogenesis by combining the Landau deuterated water measurement of gluconeogenesis with 13C isotopomer analysis After moving to Coimbra, Portugal, he applied this approach for characterizing the nutrient precursors of hepatic glycogen synthesis. Currently, he is developing methods for identifying the nutrient sources of acetyl-CoA for hepatic de novo lipogenesis and fatty acid elongation. Outside of research, he has longstanding passions for fly-fishing, golf and brewing beer.
Identificação

Identificação pessoal

Nome completo
John Griffith Jones

Nomes de citação

  • Jones, John

Identificadores de autor

Ciência ID
B81B-FD5E-E743
ORCID iD
0000-0002-3745-3885

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde - Nutrição e Dietética

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Galês (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador independente (B2) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
1985/09/01 - 1991/05/01
Concluído
Applied Chemistry (Doctor of Philosophy)
University of Texas at Arlington, Estados Unidos
1981/09/15 - 1985/05/31
Concluído
Biology and Chemistry (Bachelor)
University of Stirling, Reino Unido
Percurso profissional

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2002/04/01 - Atual Senior Researcher Universidade de Coimbra, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - 2021/10/31 High-sensitivity 13C NMR isotopomer analysis of triglyceride fatty acid enrichment from [U-13C]fructose
P17827
Investigador responsável
National High Magnetic Field Laboratory, Estados Unidos
Em curso
2019 - 2021/06/30 Coffee protects against NAFLD progression through preservation of intestinal permeability and inhibition of liver fibrosis
ISIC
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
The Institute for Scientific Information on Coffee (ISIC)
Em curso
2018 - 2021/05/31 The Role of Visceral Fructose Metabolism in the Development of Non-alcoholic Fatty Liver Disease
02/SAICT/2017/028147
Investigador responsável
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2017 - 2020/12 Metabolism and the Liver-Gut Axis in Non-Alcoholic Fatty Liver Disease
H2020-MSCA-RISE-2016-734719
European Commission
2017 - 2020 Metabolism and the Liver-Gut Axis in Non-Alcoholic Fatty Liver Disease
H2020-MSCA-ITN-2016-722619
European Commission
2016 - 2019/04 Prognostic and Protective Roles of the Clusterin-PON1 axis Against Obesity Complications
PTDC/BIM-MET/4265/2014
Provided by PTCRIS: 124913
Fundação para a Ciência e a Tecnologia, I.P.
1985 - 2016/07 Southwestern NMR Center for in Vivo Metabolism National Center for Advancing Translational Sciences
2013 - 2016/05 Anticipating diabetes and diabetic wounding for siblings of Type 2 diabetics. Fundação para a Ciência e a Tecnologia, I.P.
2013 - 2015/12 Identification and validation of biomarker genes to improve the production of Sparus aurata by optimizing the use of dietary nutrients
MICINN AGL2012-33305
Ministro de Economia e Competitividad
2013 - 2015/07 The Effect of TCF7L2 on Glucose Metabolism
DK 078646-06
National Institutes of Health Office of the Director
2010 - 2013/09 Optimizing carbohydrate utilization in farmed sea-bass through metabolic profiling Fundação para a Ciência e a Tecnologia, I.P.
2009 - 2012/07 Effect of Transaldolase Enzyme Pathway on Gluconeogenesis in People with Prediabetes
DK29953
National Institutes of Health Office of the Director
2007 - 2010/12 Disruption of hepatic glucose and lipid metabolism by immunosuppressive agents: implications for diagnosis and treatment of posttransplant diabetes Fundação para a Ciência e a Tecnologia, I.P.
2009 - 2009/10 Study of the possible environmental and molecular mechanisms responsible for Insulin Resistance, Type 2 Diabetes and Obesity in Portugal Fundação para a Ciência e a Tecnologia, I.P.
2006 - 2008/12 Noninvasive measurement of hepatic glycogen kinetics in Type 1 diabetics
1-2006-74
Juvenile Diabetes Research Foundation International
2005 - 2008/08 Improvement of insulin oral availability through encapsulation in polyelectrolyte complex nanoparticles Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2008/06 Study of the possible environmental and molecular mechanisms responsible for Insulin Resistance, Type 2 Diabetes and Obesity in Portugal Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2008/06 Study of the possible environmental and molecular mechanisms responsible for Insulin Resistance, Type 2 Diabetes and Obesity in Portugal Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2007/09 Hepatic intermediary metabolism of glucose in children with and without hepatic glucose-6-phosphatase activity
POCTI/QUI/55603/2004
Fundação para a Ciência e a Tecnologia
2005 - 2007/06 Design of new Vanadium compounds: towards their application as anti-diabetic and anti-cancer agents Fundação para a Ciência e a Tecnologia
2004 - 2005/07 Noninvasive assessment of hepatic glycogen metabolism in Type 1 diabetics
5-2004-306
Juvenile Diabetes Research Foundation International
Produções

Publicações

Artigo em revista
  1. Getachew Debas Belew; John G. Jones. "De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers". European Journal of Clinical Investigation (2022): https://doi.org/10.1111/eci.13733.
    10.1111/eci.13733
  2. Coelho, Margarida; Mahar, Rohit; Belew, Getachew D.; Torres, Alejandra; Barosa, Cristina; Cabral, Fernando; Viegas, Ivan; et al. "Enrichment of hepatic glycogen and plasma glucose from (H2O)-O-18 informs gluconeogenic and indirect pathway fluxes in naturally feeding mice". NMR in Biomedicine (2022): https://publons.com/wos-op/publon/54600422/.
    10.1002/NBM.4837
  3. Patricio, Joao S.; Dias-Pedroso, Daniela; Carvalho, Rui A.; Viera, Helena L. A.; Jones, John G.. "A simple method for quantifying de novo lipogenesis rate and substrate selection in cell cultures by C-13 NMR isotopomer analysis of the crude lipid fraction". NMR in Biomedicine (2022): https://publons.com/wos-op/publon/50808444/.
    10.1002/NBM.4648
  4. Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simoes, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Ines; et al. "Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(4) activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage". Free Radical Biology and Medicine (2022): https://publons.com/wos-op/publon/51770689/.
    10.1016/J.FREERADBIOMED.2021.12.304
  5. Molina-Molina, Emilio; Furtado, Guilherme Eustaquio.; Jones, John G.; Portincasa, Piero; Vieira-Pedrosa, Ana; Teixeira, Ana Maria; Barros, Marcelo Paes; Bachi, Andre Luis Lacerda; Sardao, Vilma A.. "The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women". European Journal of Clinical Investigation (2022): https://publons.com/wos-op/publon/49682785/.
    10.1111/ECI.13731
  6. Amorim, Ricardo; Simoes, Ines C. M.; Teixeira, Jose; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al. "Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems". Redox Biology (2022): https://publons.com/wos-op/publon/53932683/.
    10.1016/J.REDOX.2022.102400
  7. John G. Jones. "Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy". Metabolites 11 11 (2021): 751-751. https://doi.org/10.3390/metabo11110751.
    10.3390/metabo11110751
  8. Cristina Barosa; Rogério T. Ribeiro; Rita Andrade; João F. Raposo; John G. Jones. "Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects". Journal of Clinical Medicine (2021): https://doi.org/10.3390/jcm10040596.
    10.3390/jcm10040596
  9. Dias-Pedroso, Daniela; Ramalho, Jose S.; Sardao, Vilma A.; Jones, John G.; Romao, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L. A.. "Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells". Molecular Neurobiology (2021): https://publons.com/wos-op/publon/50262822/.
    10.1007/S12035-021-02630-4
  10. Borges, Diego O.; Patarrao, Rita S.; Ribeiro, Rogerio T.; de Oliveira, Rita Machado; Duarte, Nadia; Belew, Getachew Debas; Martins, Madalena; et al. "Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits". Metabolism (2021): https://publons.com/wos-op/publon/41702324/.
    10.1016/J.METABOL.2021.154735
  11. Sousa, Luis; Guarda, Mariana; Meneses, Maria Joao; Macedo, M. Paula; Vicente Miranda, Hugo. "Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases". The Journal of Pathology (2021): https://publons.com/wos-op/publon/49707570/.
    10.1002/PATH.5777
  12. Laurenti, Marcello C.; Dalla Man, Chiara; Varghese, Ron T.; Andrews, James C.; Jones, John G.; Barosa, Cristina; Rizza, Robert A.; et al. "Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans". The Journal of Clinical Endocrinology & Metabolism (2021): https://publons.com/wos-op/publon/46827652/.
    10.1210/CLINEM/DGAB100
  13. Torres, Alejandra N.; Tavares, Ludgero; Pereira, Maria J.; Eriksson, Jan W.; Jones, John G.. "Positional and compositional analysis of saturated, monounsaturated, and polyunsaturated fatty acids in human adipose tissue triglyceride by C-13 nuclear magnetic resonance". NMR in Biomedicine (2021): https://publons.com/wos-op/publon/50291978/.
    10.1002/NBM.4632
  14. Jones, John. "Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice". Scientific Reports (2020): http://dx.doi.org/10.1038/s41598-020-69820-3.
    10.1038/s41598-020-69820-3
  15. Getachew D. Belew; Giada Di Nunzio; Ludgero Tavares; Joao G. Silva; Alejandra N. Torres; John G. Jones. "Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C-isotopomers derived from [U- 13 C]fructose and [U- 13 C]glucose". Magnetic Resonance in Medicine 84 5 (2020): 2765-2771. https://doi.org/10.1002/mrm.28286.
    10.1002/mrm.28286
  16. Jones, John. "Metabolic incorporation of H 2 18 O into specific glucose-6-phosphate oxygens by red-blood-cell lysates as observed by 13 C isotope-shifted NMR signals". NMR in Biomedicine (2020): http://dx.doi.org/10.1002/nbm.4395.
    10.1002/nbm.4395
  17. Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas. "The Potential of Metabolomics in the Diagnosis of Thyroid Cancer". International Journal of Molecular Sciences 21 15 (2020): 5272-5272. https://doi.org/10.3390/ijms21155272.
    10.3390/ijms21155272
  18. Jones, John. "Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance". JCI Insight (2020): http://dx.doi.org/10.1172/jci.insight.134520.
    10.1172/jci.insight.134520
  19. Jones, John. "Limitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics". Frontiers in Physiology (2020): http://dx.doi.org/10.3389/fphys.2020.00205.
    10.3389/fphys.2020.00205
  20. Barosa, Cristina; Shanmugam, Harshitha; Cabral, Fernando; Jones, John G.. "p-Aminobenzoic acid as an alternative chemical biopsy agent for human hepatic UDP-glucose". Analytical Biochemistry 590 (2020): 113511. http://dx.doi.org/10.1016/j.ab.2019.113511.
    10.1016/j.ab.2019.113511
  21. Getachew Debas Belew; Joao Silva; Joao Rito; Ludgero Tavares; Ivan Viegas; Jose Teixeira; Paulo J. Oliveira; Maria Paula Macedo; John G. Jones. "Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis". Journal of Lipid Research 60 12 (2019): 2050-2056. https://doi.org/10.1194/jlr.RA119000354.
    10.1194/jlr.RA119000354
  22. Silva, João C.P.; Marques, Cátia; Martins, Fátima O.; Viegas, Ivan; Tavares, Ludgero; Macedo, Maria Paula; Jones, John G.. "Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue". Metabolic Engineering 56 (2019): 69-76. http://dx.doi.org/10.1016/j.ymben.2019.08.018.
    10.1016/j.ymben.2019.08.018
  23. Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís F. Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira. "A Mitochondrial Approach to Cardiovascular Risk and Disease". Current Pharmaceutical Design 25 29 (2019): 3175-3194. https://doi.org/10.2174/1389203720666190830163735.
    10.2174/1389203720666190830163735
  24. Jones, John. "27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019". Cardiovascular Endocrinology & Metabolism (2019): http://dx.doi.org/10.1097/xce.0000000000000179.
    10.1097/xce.0000000000000179
  25. Jonás I. Silva-Marrero; Juliana Villasante; Ania Rashidpour; Mariana Palma; Anna Fàbregas; María Pilar Almajano; Ivan Viegas; et al. "The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata". Biomolecules 9 8 (2019): 297-297. https://doi.org/10.3390/biom9080297.
    10.3390/biom9080297
  26. Araújo, Pedro M.; Viegas, Ivan; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Mendonça, Liliana; Ramos, Jaime A.; Masero, José A.; Alves, José A.. "Understanding how birds rebuild fat stores during migration: insights from an experimental study". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-46487-z.
    10.1038/s41598-019-46487-z
  27. Viegas, Ivan; Trenkner, Lauren H.; Rito, João; Palma, Mariana; Tavares, Ludgero C.; Jones, John G.; Glencross, Brett D.; Wade, Nicholas M.. "Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer)". Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 231 (2019): 170-176. http://dx.doi.org/10.1016/j.cbpa.2019.02.025.
    10.1016/j.cbpa.2019.02.025
  28. Rito, João; Viegas, Ivan; Pardal, Miguel Â.; Metón, Isidoro; Baanante, Isabel V.; Jones, John G.. "Utilization of glycerol for endogenous glucose and glycogen synthesis in seabass (Dicentrarchus labrax): A potential mechanism for sparing amino acid catabolism in carnivorous fish". Aquaculture 498 (2019): 488-495. http://dx.doi.org/10.1016/j.aquaculture.2018.08.066.
    10.1016/j.aquaculture.2018.08.066
  29. Jarak, Ivana; Barosa, Cristina; Martins, Fatima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, Joao; et al. "Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate". Magnetic Resonance in Medicine 81 1 (2018): 639-644. http://dx.doi.org/10.1002/mrm.27378.
    10.1002/mrm.27378
  30. Silva, João C. P.; Mota, Marta; Martins, Fátima O.; Nogueira, Célia; Gonçalves, Teresa; Carneiro, Tatiana; Pinto, Joana; et al. "Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets". Journal of Proteome Research 17 8 (2018): 2880-2891. http://dx.doi.org/10.1021/acs.jproteome.8b00354.
    10.1021/acs.jproteome.8b00354
  31. Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Meton, Isidoro; Baanante, Isabel V.; Jones, John G.. "Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream". Scientific Reports 8 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419941000005&KeyUID=WOS:000419941000005.
    10.1038/s41598-017-19087-y
  32. Huang, Hu; Lee, Seung-Hwan; Sousa-Lima, Ines; Kim, Sang Soo; Hwang, Won Min; Dagon, Yossi; Yang, Won-Mo; et al. "Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition". Journal of Clinical Investigation 128 12 (2018): 5335-5350. https://publons.com/wos-op/publon/19310035/.
    10.1172/JCI63562
  33. Viegas, Ivan; Araujo, Pedro M.; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Ramos, Jaime A.; Masero, Jose A.; Alves, Jose A.. "Metabolic plasticity for subcutaneous fat accumulation in a longdistance migratory bird traced by (H2O)-H-2". Journal of Experimental Biology 220 6 (2017): 1072-1078. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000397614200019&KeyUID=WOS:000397614200019.
    10.1242/jeb.150490
  34. Flachs, P.; Adamcova, K.; Zouhar, P.; Marques, C.; Janovska, P.; Viegas, I.; Jones, Jg; et al. "Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype". International Journal of Obesity 41 3 (2017): 372-380. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000395816000003&KeyUID=WOS:000395816000003.
    10.1038/ijo.2016.228
  35. Hernandez, Elisa Alvarez; Kahl, Sabine; Seelig, Anett; Begovatz, Paul; Irmler, Martin; Kupriyanova, Yuliya; Nowotny, Bettina; et al. "Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance". Journal of Clinical Investigation 127 2 (2017): 695-708. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000394164100029&KeyUID=WOS:000394164100029.
    10.1172/JCI89444
  36. Jones, John G; Silva, Joao C P. "Improving Metabolic Control Through Functional Foods.". Current medicinal chemistry (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:28545368&KeyUID=MEDLINE:28545368.
    10.2174/0929867324666170523130123
  37. Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Jones, John G.. "Evidence of extensive plasma glucose recycling following a glucose load in seabass". Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology 211 (2017): 41-48. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406565900006&KeyUID=WOS:000406565900006.
    10.1016/j.cbpa.2017.05.009
  38. Varghese, Ron T.; Man, Chiara Dalla; Sharma, Anu; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; et al. "Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans". Journal of Clinical Endocrinology & Metabolism 101 12 (2016): 4816-4824. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000390951000035&KeyUID=WOS:000390951000035.
    10.1210/jc.2016-1998
  39. Gonzalez, Juan D.; Silva-Marrero, Jonas I.; Meton, Isidoro; Caballero-Solares, Albert; Viegas, Ivan; Fernandez, Felipe; Minarro, Montserrat; et al. "Chitosan-Mediated shRNA Knockdown of Cytosolic Alanine Aminotransferase Improves Hepatic Carbohydrate Metabolism". Marine Biotechnology 18 1 (2016): 85-97. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000378136600007&KeyUID=WOS:000378136600007.
    10.1007/s10126-015-9670-8
  40. Marques, Catia; Viegas, Filipa; Rito, Joao; Jones, John; Viegas, Ivan. "Determination of muscle protein synthesis rates in fish using (H2O)-H-2 and H-2 NMR analysis of alanine". Analytical Biochemistry 509 (2016): 111-114. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000380866800018&KeyUID=WOS:000380866800018.
    10.1016/j.ab.2016.07.011
  41. Coelho, Margarida; Valente-Silva, Paula; Tylki-Szymanska, Anna; Henriques, Tiago; Barosa, Cristina; Carvalho, Filipa; Jones, John G.. "Demonstration of Glucose-6-Phosphate Hydrogen 5 Enrichment from Deuterated Water by TransaldolaseMediated Exchange Alone". Magnetic Resonance in Medicine 75 4 (2016): 1781-1786. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372910900040&KeyUID=CCC:000372910900040.
  42. Jones, John G.; Jones, John G. "Hepatic glucose and lipid metabolism". Diabetologia 59 6 (2016): 1098-1103. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000378048500004&KeyUID=CCC:000378048500004.
    10.1007/s00125-016-3940-5
  43. Coelho, Margarida; Valente-Silva, Paula; Tylki-Szymanska, Anna; Henriques, Tiago; Barosa, Cristina; Carvalho, Filipa; Jones, John G. "Demonstration of glucose-6-phosphate hydrogen 5 enrichment from deuterated water by transaldolase-mediated exchange alone.". Magnetic resonance in medicine 75 4 (2016): 1781-6. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:25995077&KeyUID=MEDLINE:25995077.
    10.1002/mrm.25749
  44. Varghese, Ron T.; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; Rizza, Robert A.; Jones, John G.; Venal, Adrian. "Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance". Diabetes 65 4 (2016): 887-892. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372859200008&KeyUID=CCC:000372859200008.
    10.2337/DB15-1593
  45. Coelho, Margarida; Mendes, Vera M.; Lima, Ines S.; Martins, Fatima O.; Fernandes, Ana B.; Paula Macedo, M.; Jones, John G.; Manadas, Bruno. "Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS". Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 1022 (2016): 242-248. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000376545800032&KeyUID=WOS:000376545800032.
    10.1016/j.jchromb.2016.04.027
  46. Viegas, Ivan; Jarak, Ivana; Rito, Joao; Carvalho, Rui A; Meton, Isidoro; Pardal, Miguel A; Baanante, Isabel V; Jones, John G. "Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.).". Journal of lipid research 57 7 (2016): 1264-72. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:27247346&KeyUID=MEDLINE:27247346.
    10.1194/jlr.M067850
  47. Martins, Fatima O.; Delgado, Teresa C.; Viegas, Joana; Gaspar, Joana M.; Scott, Donald K.; O'Doherty, Robert M.; Macedo, M. Paula; Jones, John G.. "Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia". British Journal of Pharmacology 173 2 (2016): 267-278. https://publons.com/wos-op/publon/2029575/.
    10.1111/BPH.13362
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  104. JONES, JG; SHERRY, AD; JEFFREY, FMH; STOREY, CJ; MALLOY, CR. "SOURCES OF ACETYL-COA ENTERING THE TRICARBOXYLIC-ACID CYCLE AS DETERMINED BY ANALYSIS OF SUCCINATE C-13 ISOTOPOMERS". Biochemistry 32 45 (1993): 12240-12244. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1993MG89300037&KeyUID=WOS:A1993MG89300037.
    10.1021/bi00096a037
  105. Jones, J.G.; Sherry, A.D.; Jeffrey, F.M.H.; Storey, C.J.; Malloy, C.R.. "Sources of acetyl-CoA entering the tricarboxylic acid cycle as determined by analysis of succinate 13C isotopomers". Biochemistry 32 45 (1993): 12240-12244. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027359228&partnerID=MN8TOARS.
  106. JONES, JG; BELLION, E. "METHYLAMINE METABOLISM IN HANSENULA-POLYMORPHA - AN INVIVO C-13 AND P-31 NUCLEAR-MAGNETIC-RESONANCE STUDY". JOURNAL OF BACTERIOLOGY 173 16 (1991): 4959-4969. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GB01400007&KeyUID=WOS:A1991GB01400007.
    10.1128/JB.173.16.4959-4969.1991
  107. JONES, JG; BELLION, E. "METHANOL OXIDATION AND ASSIMILATION IN HANSENULA-POLYMORPHA - AN ANALYSIS BY C-13 NMR INVIVO". BIOCHEMICAL JOURNAL 280 (1991): 475-481. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GU90100031&KeyUID=WOS:A1991GU90100031.
    10.1042/BJ2800475
  108. JONES, JG; BELLION, E. "INVIVO C-13 AND N-15 NMR-STUDIES OF METHYLAMINE METABOLISM IN PSEUDOMONAS SPECIES MA". JOURNAL OF BIOLOGICAL CHEMISTRY 266 18 (1991): 11705-11713. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991FT76200046&KeyUID=WOS:A1991FT76200046.
Capítulo de livro
  1. Viegas, Ivan; Albuquerque Carvalho, Rui de; ngelo, Miguel; Griffith, John. "Advances and Applications of Tracer Measurements of Carbohydrate Metabolism in Fish". In New Advances and Contributions to Fish Biology. InTech, 2012.
    10.5772/54053
  2. Barosa, C.; Jones, J. G.. "Recent Developments in the use of Stable Isotope Carbohydrate Tracers for the Study of Human Health". editado por Rauter, A. P.; Lindhorst, T. K., 208-226. 2011.
    10.1039/9781849732765-00208
Livro
  1. Jones, John. Dietary Sugars. Royal Society of Chemistry. 2012.
    10.1039/9781849734929
  2. Jones, John. Carbohydrate Chemistry. Royal Society of Chemistry. 2011.
    10.1039/9781849732765
  3. Jones, J.G.. Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O. 2007.
    10.1002/9780470513095.ch8

Propriedade Intelectual

Patente
  1. Jones, John. 2011. "Methods of Distinguishing Between Glutamine Formed by Cataplerosis or Proteolysis". Estados Unidos.
  2. Jones, John. 2007. "Measurements of gluconeogenesis and intermediary metabolism using stable isotopes".
  3. Jones, John. 2001. "Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling". Estados Unidos.
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2010/10/01 - 2014/12/02 Brain-liver Nitric oxide – A Major Player in Insulin Clearance and Actions
2008/10/01 - 2012/11/12 Sources of Blood Glucose and Liver Glycogen in the Seabass: Implications for Carbohydrate Metabolism in Fish
2007/10/01 - 2012/01/20 Noninvasive Measurements of Human Hepatic Metabolism Using Deuterated Water
2007/01/01 - 2011/06/15 Profiling the control of hepatic glucose and lipid metabolism for evaluating novel strategies of insulin delivery
2005/10 - 2009/03 Insulin Resistance & Diabetes: Insights from Magnetic Resonance Studies of Hepatic Glucose & Lipid Metabolism

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019/05/09 - 2019/05/10 EASD-EGIR meeting in Lisbon (2019/05/09 - 2019/05/10)
Conferência (Coorganizador)
2019/05/08 - 2019/05/09 EASD-NAFLD meeting in Lisbon (2019/05/08 - 2019/05/09)
Conferência (Coorganizador)

Membro de associação

Nome da associação Tipo de participação
2005/03/01 - Atual Portuguese Society of Diabetology Head of the Group for Fundamental and Translational Investigation (GIFT) since 2018
2005/01/01 - Atual European Association for the Study of Diabetes
Distinções

Prémio

2008 GSK IdeaSpring Prize, Most Promising Innovative Technology
2005 Portuguese Society of Diabetes-JABA Industry Hargreaves Prize, Best Research Study on Diabetes in Portugal in 2004