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M. Matilde Marques was born in Santarém, Portugal. She holds B.S. and Ph.D. degrees in chemical engineering and a Habilitation degree (D.Sc.) in chemistry from Instituto Superior Técnico (IST), University of Lisbon, Portugal. She conducted postdoctoral work in chemical carcinogenesis at the FDA National Center for Toxicological Research, USA, and is currently a full professor at the Department of Chemical Engineering of IST, where she teaches organic and medicinal chemistry. She coordinated the M.S. and Ph.D. Chemistry Programs at IST until December 2016 and is currently vice-chair of IST¿s Scientific Council. Her research focuses on the mechanisms of toxicity induced by environmental (e.g., aromatic amines, acrylamide) and therapeutic (e.g., antiestrogens, anti-HIV drugs) xenobiotics, on the development/validation of analytical methodologies for the detection and quantitation of biomarkers of exposure to toxic agents, with emphasis on MS-based methodologies, and on the design, synthesis, and biological evaluation of potential therapeutic agents. She is a Member of the American Association for Cancer Research, the American Chemical Society, and the Royal Society of Chemistry. She has chaired the Division of Medicinal Chemistry of the Portuguese Chemical Society (2016-2020) and has been Council Member of the European Federation for Medicinal Chemistry (EFMC) (2016-2020). She has served (2008-2022) on the Editorial Advisory Board for Chemical Research in Toxicology, currently serves on the editorial board of Pharmaceuticals, and has been a Member of multiple working groups for the International Agency for Research on Cancer.
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Identificação

Identificação pessoal

Nome completo
M Matilde Marques

Nomes de citação

  • Marques, M Matilde

Identificadores de autor

Ciência ID
AB1A-1A93-03C0
ORCID iD
0000-0002-7526-4962
Google Scholar ID
https://scholar.google.pt/citations?user=A4CX5p0AAAAJ&hl=pt-PT
Researcher Id
E-2535-2012
Scopus Author Id
35492817000

Endereços de correio eletrónico

  • matilde.marques@tecnico.ulisboa.pt (Profissional)

Telefones

Telefone
  • 218419200 (Profissional)

Moradas

  • Centro de Química Estrutural, IST, Av. Rovisco Pais, 1, 1049-001, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Exatas - Química

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador independente (B2) Utilizador proficiente (C2) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador elementar (A2) Utilizador proficiente (C1) Utilizador elementar (A2) Utilizador proficiente (C1) Utilizador independente (B1)
Formação
Grau Classificação
2004/10/27
Concluído
 M. Matilde Marques (Título de Agregado)
Especialização em Chemistry
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Unanimity
1987
Concluído
 Engenharia Química (Doutoramento)
Especialização em Sem especialidade
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Reactividade e Aplicações Sintéticas de Hidroxilaminas e Derivados" (TESE/DISSERTAÇÃO)
 Distinção e Louvor
1979
Concluído
 M. Matilde Marques (Licenciatura)
Especialização em Chemical Engineering
Universidade de Lisboa Instituto Superior Técnico, Portugal
 17/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1987 - 1988 Pós-doutorado (Investigação) National Center for Toxicological Research, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2016 - Atual Professor Catedrático (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
1995 - 2015 Professor Associado (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal
1987 - 1995 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Conselho científico (vice-presidente) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2023/12/31 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Lisboa Centro de Química Estrutural, Portugal
2013 - 2016 Conselho pedagógico Universidade de Lisboa Instituto Superior Técnico, Portugal
Projetos

Projeto

Designação Financiadores
2018/10/01 - 2022/09/30 From Drug Design to Chemical Toxicology: shaping predictive tools with Mass Spectrometry
PTDC/QUI-QAN/32242/2017
Investigador responsável
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/09/01 - 2022/08/31 Fighting metastatic cancers: prime time for ruthenium
PTDC/QUI-QIN/28662/2017
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade do Minho, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2017/01/01 - 2021/06/30 PRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
SAICTPAC/0019/2015
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Instituto Politécnico de Leiria, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2013/06/01 - 2016/12/31 From small bioactive molecules to an integrated OMICS approach: Mass Spectrometry tools for mechanistic insights into drug-like and functional properties, toxicity, and stress responses
RECI/QEQ-MED/0330/2012
Investigador responsável
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Hospital Professor Doutor Fernando Fonseca EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/06/01 - 2016/12/31 From drug design to new materials: structural approach in emergent fields
RECI/QEQ-QIN/0189/2012
Investigador
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/03/15 - 2014/09/14 Hepatic toxicity in HIV-infected individuals exposed to nevirapine
PTDC/SAU-TOX/111663/2009
Investigador
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/02/01 - 2014/07/31 Bioactivation routes of the anti-HIV drug Nevirapine: identification of reactive metabolites and mutagenic potential
PTDC/QUI-QUI/113910/2009
Investigador responsável
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/07/31 BIOMARKERS OF DIETARY ACRYLAMIDE EXPOSURE: HUMAN TOXICOLOGICAL RELEVANCE.
PTDC/SAU-OSM/105572/2008
Investigador
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/04/30 Electron Transfer in Organic Mixed-Valence Radical-Ions
PTDC/QUI-QUI/101433/2008
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/02 - 2012/06/30 Novel bioorganometallic SERM analogues - synthesis and evaluation of anti-cancer potential
PTDC/QUI/67522/2006
Investigador responsável
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2009 Genetic Lesion Induced by Acrylamide: What Is the Relevance for Mammary, Thyroid, and Central Nervous System Carcinogenesis?;
nn
Investigador
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação Calouste Gulbenkian
Concluído
2005/10/15 - 2008/06/30 BREAST CANCER: EVALUATION OF THE ROLE OF ENVIRONMENTAL AND FOOD CARCINOGENS IN ITS INITIATION
POCI/QUI/57110/2004
Investigador responsável
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/10/01 - 2008/06/30 Controlling pharmaceuticals behaviour by Crystal Engineering
POCI/QUI/58791/2004
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/09/15 - 2008/06/30 Anti-HIV Drugs: Genotoxic Evaluation and Synthetic Strategies
POCI/QUI/56582/2004
Investigador responsável
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2008 Characterization of Biological Factors and Lifestyles with Impact on the Occurrence and Types of Cancer Identification of Risk Factors for Primary Tumors of the Central Nervous System
nn
Investigador
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação Calouste Gulbenkian
Concluído
2001 - 2005 Evaluation of the Genotoxic and AntiEstrogenic Potential of Triphenyethylene Derivatives and their Metabolites
POCTI/33544/QUI/2000
Investigador responsável
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
1997 - 2000 DNA Interaction with Tamoxifen Metabolites
PRAXIS/PCEX/C/QUI/51/96
Investigador responsável
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
1996 - 1997 DNA adducts of tamoxifen
nn
Bolseiro de Cientista Convidado
National Center for Toxicological Research, Estados Unidos
 Food and Drug Administration Office of Women's Health
Concluído
1996 - 1997 DNA Adduct Structure: Effects on Mutation Induction
CRG960165
Investigador responsável
Universidade de Lisboa Centro de Química Estrutural, Portugal
 NATO
Concluído
1992 - 1995 Chemical Modification of DNA: Characterization and Conformational Analysis of the Products
PBIC/C/CEN/1154/92
Investigador responsável
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
1992 - 1994 Synthesis and Molecular Recognition of Nucleosides Modified with Carcinogenic Agents
STRDA/C/AMB/347/92
Investigador
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
1992 - 1994 O-Acetylation of carcinogenic N-hydroxyarylamines
CRG910561
Investigador responsável
Universidade de Lisboa Centro de Química Estrutural, Portugal
 NATO
Concluído
Produções

Publicações

Artigo em conferência
  1. Marques, M. "Adverse reactions induced by the antiepileptic drug oxcarbazepine may stem from its metabolic biotransformation to carbamazepine". 2018.
    Publicado
  2. Li, L.; Chiarelli, M.P.; Branco, P.S.; Antunes, A.M.; Marques, M.M.; Gonçalves, L.L.; Beland, F.A.. "Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry". 2002.
    Publicado
Artigo em revista
  1. Riboli, Elio; Beland, Frederick A; Lachenmeier, Dirk W; Marques, M Matilde; Phillips, David H; Schernhammer, Eva; Afghan, Abdul; et al. "Carcinogenicity of aspartame, methyleugenol, and isoeugenol". The Lancet Oncology 24 8 (2023): 848-850. http://dx.doi.org/10.1016/s1470-2045(23)00341-8.
    Publicado • 10.1016/s1470-2045(23)00341-8
  2. Marques, Cátia F.; Marques, M. Matilde; Justino, Gonçalo C.. "The mechanisms underlying montelukast's neuropsychiatric effects - new insights from a combined metabolic and multiomics approach". Life Sciences 310 (2022): 121056. http://dx.doi.org/10.1016/j.lfs.2022.121056.
    Publicado • 10.1016/j.lfs.2022.121056
  3. Cátia F. Marques; Maria Matilde Marques; Gonçalo C. Justino. "Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing". Pharmaceuticals (2022): https://doi.org/10.3390/ph15091039.
    10.3390/ph15091039
  4. M. Emília Sousa; M. Matilde Marques; M. Amparo F. Faustino. "1st Spring Virtual Meeting on Medicinal Chemistry". Chemistry Proceedings (2021): https://doi.org/10.3390/chemproc2021004001.
    10.3390/chemproc2021004001
  5. Leitão, Inês; Martins, Luisa L.; Carvalho, Luisa; Oliveira, M. Conceição; Marques, M. Matilde; Mourato, Miguel P.. "Acetaminophen Induces an Antioxidative Response in Lettuce Plants". Plants 10 6 (2021): 1152. http://dx.doi.org/10.3390/plants10061152.
    10.3390/plants10061152
  6. Leitão, Inês; Mourato, Miguel Pedro; Carvalho, Luísa; Oliveira, Maria Conceição; Marques, Maria Matilde; Martins, Luisa Louro. "Antioxidative response of lettuce (Lactuca sativa) to carbamazepine-induced stress". Environmental Science and Pollution Research (2021): http://dx.doi.org/10.1007/s11356-021-13979-3.
    Publicado • 10.1007/s11356-021-13979-3
  7. Harjivan, Shrika G.; Charneira, Catarina; Martins, Inês L.; Pereira, Sofia A.; Espadas, Guadalupe; Sabidó, Eduard; Beland, Frederick A.; Marques, M. Matilde; Antunes, Alexandra M. M.. "Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine". Molecules 26 5 (2021): 1349. http://dx.doi.org/10.3390/molecules26051349.
    Acesso aberto • Publicado • 10.3390/molecules26051349
  8. Ramilo-Gomes, Filipa; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Campos, Débora L.; Pavan, Fernando R.; Gomes, Clara S.B.; et al. "Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc(II) complexes". Journal of Inorganic Biochemistry 216 (2021): 111331. http://dx.doi.org/10.1016/j.jinorgbio.2020.111331.
    Publicado • 10.1016/j.jinorgbio.2020.111331
  9. Marques, M Matilde; Beland, Frederick A; Lachenmeier, Dirk W; Phillips, David H; Chung, Fung-Lung; Dorman, David C; Elmore, Sarah E; et al. "Carcinogenicity of acrolein, crotonaldehyde, and arecoline". The Lancet Oncology 22 1 (2021): 19-20. http://dx.doi.org/10.1016/s1470-2045(20)30727-0.
    10.1016/s1470-2045(20)30727-0
  10. Marinho, Aline T.; Batuca, Joana R.; Miranda, Joana P.; Caixas, Umbelina; Dias, Clara G.; Branco, Teresa; Soto, Karina; et al. "The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies". Pharmacological Research (2021): 105446. http://dx.doi.org/10.1016/j.phrs.2021.105446.
    No prelo • 10.1016/j.phrs.2021.105446
  11. Inês Leitão; Miguel P. Mourato; Joana Sales; Maria Matilde Marques; Maria Conceição Oliveira; Luisa L. Martins. "Effects of Metformin on Antioxidative Response of Lactuca sativa Plants". Biology and Life Sciences Forum (2020): https://doi.org/10.3390/IECPS2020-08771.
    10.3390/IECPS2020-08771
  12. Pinheiro, Pedro F.; Justino, Gonçalo C.; Marques, M. Matilde. "NKp30 - A prospective target for new cancer immunotherapy strategies". British Journal of Pharmacology 177 20 (2020): 4563-4580. http://dx.doi.org/10.1111/bph.15222.
    10.1111/bph.15222
  13. Cipriano, Madalena; Pinheiro, Pedro F; Sequeira, Catarina O; Rodrigues, Joana S; Oliveira, Nuno G; Antunes, Alexandra M M; Castro, Matilde; et al. "Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model". International Journal of Molecular Sciences 21 11 (2020): 3998. http://dx.doi.org/10.3390/ijms21113998.
    Acesso aberto • Publicado • 10.3390/ijms21113998
  14. Mahgoub, Mohamed Y.; Elmaghraby, Awatef M.; Harb, Abd-Elfttah A.; Ferreira da Silva, João L.; Justino, Gonçalo C.; Marques, M. Matilde. "Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors". Molecules 24 12 (2019): 2306. http://dx.doi.org/10.3390/molecules24122306.
    Acesso aberto • Publicado • 10.3390/molecules24122306
  15. Braga, Cláudia; Vaz, Ana R.; Oliveira, M. Conceição; Matilde Marques, M.; Moreira, Rui; Brites, Dora; Perry, Maria J.. "Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability". European Journal of Medicinal Chemistry 172 (2019): 16-25. http://dx.doi.org/10.1016/j.ejmech.2019.03.048.
    Publicado • 10.1016/j.ejmech.2019.03.048
  16. Marques, M Matilde; Berrington de Gonzalez, Amy; Beland, Frederick A.; Browne, Patience; Demers, Paul A; Lachenmeier, Dirk W; Bahadori, Tina; et al. "Advisory Group recommendations on priorities for the IARC Monographs". The Lancet Oncology 20 6 (2019): 763-764. http://dx.doi.org/10.1016/s1470-2045(19)30246-3.
    10.1016/s1470-2045(19)30246-3
  17. Marinho, Aline T.; Miranda, Joana P.; Caixas, Umbelina; Charneira, Catarina; Gonçalves-Dias, Clara; Marques, M. Matilde; Monteiro, Emília C.; Antunes, Alexandra M. M.; Pereira, Sofia A.. "Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity". Drug Metabolism Reviews 51 1 (2019): 76-90. http://dx.doi.org/10.1080/03602532.2019.1577891.
    Publicado • 10.1080/03602532.2019.1577891
  18. Garcia, Sara N.; Guedes, Rita C.; Marques, M. Matilde. "Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics". Current Medicinal Chemistry 26 41 (2019): 7285-7322. http://dx.doi.org/10.2174/0929867326666181213092652.
    10.2174/0929867326666181213092652
  19. Kromhout, Hans; Friesen, Melissa; Marques, M Matilde; Sergi, Consolato Maria; Abdallah, Mohamed; Benke, Geza; Cesta, Mark; et al. "Carcinogenicity of isobutyl nitrite, ß-picoline, and some acrylates". The Lancet Oncology 19 8 (2018): 1020-1022. http://dx.doi.org/10.1016/s1470-2045(18)30491-1.
    Publicado • 10.1016/s1470-2045(18)30491-1
  20. Godinho, Ana L.A.; Martins, Inês L.; Nunes, João; Charneira, Catarina; Grilo, Jorge; Silva, Diogo M.; Pereira, Sofia A.; et al. "High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches". European Journal of Pharmaceutical Sciences 119 (2018): 70-82. http://dx.doi.org/10.1016/j.ejps.2018.03.026.
    10.1016/j.ejps.2018.03.026
  21. Marques, M. "Predicting drug metabolites using bacterial-based models". Abstracts of Papers of the American Chemical Society (2018): https://publons.com/publon/14992590/.
  22. Marques, M. "Inducing the activity of NK cells with NKp30 small organic ligands". Abstracts of Papers of the American Chemical Society (2018): https://publons.com/publon/14992591/.
  23. Martins, IL; Nunes, J; Charneira, C; Morello, J; Telo, JP; MARQUES, MM; Antunes, AMM. "The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals". Free Radical Biology and Medicine 129 (2018): 559-568. https://doi.org/10.1016/j.freeradbiomed.2018.10.408.
    Publicado • 10.1016/J.FREERADBIOMED.2018.10.408
  24. Grilo, Nádia M.; João Correia, M.; Miranda, Joana P.; Cipriano, Madalena; Serpa, Jacinta; Matilde Marques, M.; Monteiro, Emília C.; et al. "Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms". European Journal of Pharmaceutical Sciences 105 (2017): 47-54. http://dx.doi.org/10.1016/j.ejps.2017.05.010.
    10.1016/j.ejps.2017.05.010
  25. Von Tungeln, Linda S.; Walker, Nigel J.; Olson, Greg R.; Mendoza, Maria C.B.; Felton, Robert P.; Thorn, Brett T.; Marques, M. Matilde; et al. "Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study". Food and Chemical Toxicology 99 (2017): 170-181. http://dx.doi.org/10.1016/j.fct.2016.11.015.
    Publicado • 10.1016/j.fct.2016.11.015
  26. Alexandra Antunes. "Evidence of bioactivation of the anti-HIV drug etravirine to reactive metabolites in vitro and in vivo". Abstracts of Papers of the American Chemical Society (2017): https://publons.com/publon/18184341/.
  27. M. Matilde Marques; J. Paulo Telo; Inês L. Martins; Alexandra M.M. Antunes. "Toxic events induced by the antiepileptic drug carbamazepine: Is bioactivation really involved?". Toxicology Letters (2017): https://publons.com/publon/11121400/.
    10.1016/J.TOXLET.2017.07.669
  28. Pinheiro, Pedro F.; Pereira, Sofia A.; Harjivan, Shrika G.; Martins, Inês L.; Marinho, Aline T.; Cipriano, Madalena; Jacob, Cristina C.; et al. "Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study". Archives of Toxicology 91 3 (2017): 1199-1211. http://dx.doi.org/10.1007/s00204-016-1792-x.
    Publicado • 10.1007/s00204-016-1792-x
  29. Alexandra Antunes. "Reaction of the antiepileptic drug carbamazepine with bionucleophiles: Bioactivation is not required". Abstracts of Papers of the American Chemical Society (2017): https://publons.com/publon/18184342/.
  30. Joana P. Miranda; Sofia A. Pereira; Matilde Castro; Joana S. Rodrigues; M. Matilde Marques; Alexandra M.M. Antunes; Nuno G. Oliveira; et al. "3D in vitro cultures of human hepatocyte-like cells as an alternative competent model for nevirapine biotransformation studies". Toxicology Letters (2017): https://publons.com/publon/11121401/.
    10.1016/J.TOXLET.2017.07.932
  31. Grilo, N.M.; Correia, M.J.; Sequeira, C.; Harjivan, S.G.; Caixas, U.; Diogo, L.N.; Marques, M.M.; et al. "Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients". Toxicology Letters 260 (2016): 28-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987995250&partnerID=MN8TOARS.
    10.1016/j.toxlet.2016.08.009
  32. Marinho, A.T.; Dias, C.G.; Pinheiro, P.F.; Lemos, A.R.; Antunes, A.M.M.; Marques, M.M.; Monteiro, E.C.; et al. "Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach". European Journal of Pharmaceutical Sciences 82 (2016): 147-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949024137&partnerID=MN8TOARS.
    10.1016/j.ejps.2015.11.019
  33. Alexandra Antunes. "Monitoring of 8-hydroxy-efavirenz concentrations for management of mood changes". Journal of the International AIDS Society (2016): https://publons.com/publon/18184287/.
  34. C.C. Jacob; M. Marques; F.A. Beland; A. De Conti; I. Pogribny; C. Charneira; I.L. Martins; J. Nunes; Alexandra Antunes. "Modification of histone H2b in a rat model by a reactive metabolite of the chemical carcinogen and food contaminant furan". Toxicology Letters (2016): https://publons.com/publon/18184288/.
    10.1016/J.TOXLET.2016.06.1405
  35. M. Matilde Marques. "New small organic ligands for the natural cytotoxicity receptor NKp30". Abstracts of Papers of the American Chemical Society (2016): https://publons.com/publon/19002048/.
  36. J. Nunes; R.F. Gomes; M. Matilde Marques. "Synthesis and characterization of biomarkers of exposure to 1-bromopropane". Toxicology Letters (2016): https://publons.com/publon/19002059/.
    10.1016/J.TOXLET.2016.06.1368
  37. Grosse, Yann; Loomis, Dana; Guyton, Kathryn Z.; El Ghissassi, Fatiha; Bouvard, Veronique; Benbrahim-Tallaa, Lamia; Mattock, Heidi; Straif, Kurt; Int Agcy Res Canc. "Carcinogenicity of some industrial chemicals". Lancet Oncology 17 4 (2016): 419-420. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000373497600040&KeyUID=WOS:000373497600040.
    10.1016/S1470-2045(16)00137-6
  38. Alexandra M.M. Antunes; Frederick A. Beland; Aline de Conti; Igor P. Pogribny; Inês L. Martins; João Nunes; Cristina C. Jacob; M. Matilde Marques; Catarina Charneira. "New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan". Toxicology Letters (2016): https://publons.com/publon/4396379/.
    10.1016/J.TOXLET.2016.10.018
  39. Frederick A. Beland; Greg R. Olson; Maria C.B. Mendoza; M. Matilde Marques; Daniel R. Doerge. "Carcinogenicity of glycidamide in B6C3F 1 mice and F344/N rats from a two-year drinking water exposure". Food and Chemical Toxicology 86 (2015): 104-115. https://doi.org/10.1016%2Fj.fct.2015.09.017.
    10.1016/J.FCT.2015.09.017
  40. Godinho, A.; Surratt, G.; Gamboa da Costa, G.; Beland, F. A.; Antunes, A. M. M.; Marques, M. M.. "Metabolic activation of the nevirapine metabolite 12-hydroxy-nevirapine to 12-formylnevirapine - A possible factor in nevirapine toxicity". Toxicology Letters 238 2 (2015): S360-S361. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801860&KeyUID=WOS:000370693801860.
    10.1016/J.TOXLET.2015.08.1027
  41. Harjivan, S. G.; Wanke, R.; Woodling, K.; Gamboa da Costa, G.; Beland, F. A.; Antunes, A. M. M.; Marques, M. M.. "First in vitro evidence for a catechol metabolite from the anti-HIV drug efavirenz - A plausible role in toxicity". Toxicology Letters 238 2 (2015): S360-S360. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801859&KeyUID=WOS:000370693801859.
    10.1016/J.TOXLET.2015.08.1026
  42. Martins, I.; Marques, M. M.; Antunes, A.. "Protein adducts from carbamazepine-10,11-epoxide, the major metabolite of the antiepileptic drug carbamazepine: possible biomarkers of toxicity". Toxicology Letters 238 2 (2015): S359-S359. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801857&KeyUID=WOS:000370693801857.
    10.1016/j.toxlet.2015.08.1024
  43. Mahgoub, M. Y.; Cavaca, L.; Beland, F. A.; Marques, M. M.. "Activation of aloe-emodin to biologically plausible electrophiles - Possible role in the carcinogenicity of aloe vera whole leaf extracts". Toxicology Letters 238 2 (2015): S359-S359. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801856&KeyUID=WOS:000370693801856.
    10.1016/j.toxlet.2015.08.1023
  44. Harjivan, S. G.; Pinheiro, P. F.; Martins, I. L.; Novais, D. A.; Wanke, R.; Santos, P. P.; Pereira, S. A.; et al. "Enzymatic bioactivation of the phenolic nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine to quinoid intermediates: Covalent adduct formation with nitrogen-based amino acids". Toxicology Letters 238 2 (2015): S359-S360. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801858&KeyUID=WOS:000370693801858.
    10.1016/j.toxlet.2015.08.1025
  45. E.C. Monteiro; M.M. Marques; U. Caixas; T. Branco; S. Maia; M. Fonseca; S.G. Harjivan; et al. "Anti-histone antibodies in HIV-infected patients on Nevirapine-containing ANTIRETROVIRAL THERAPY". Clinical Therapeutics (2015): https://publons.com/publon/11121394/.
    10.1016/J.CLINTHERA.2015.05.408
  46. Pinheiro, P.F.; Marinho, A.T.; Antunes, A.M.M.; Marques, M.M.; Pereira, S.A.; Miranda, J.P.. "Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats". Chemico-Biological Interactions 233 (2015): 115-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926657811&partnerID=MN8TOARS.
    10.1016/j.cbi.2015.03.024
  47. Harjivan, S.G.; Pinheiro, P.F.; Martins, I.L.; Godinho, A.L.; Wanke, R.; Santos, P.P.; Pereira, S.A.; et al. "Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: Activation pathway to amino acid adducts". Toxicology Research 4 6 (2015): 1565-1577. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945273743&partnerID=MN8TOARS.
    10.1039/c5tx00176e
  48. M. Matilde Marques; Karina Shimizu; André P. Ferreira; M. Teresa Duarte; Shrika G. Harjivan; J. L. Ferreira da Silva; Ferreira Da Silva, J.L.; et al. "Effect of substituents in the molecular and supramolecular architectures of 1-ferrocenyl-2-(aryl)thioethanones". CrystEngComm 17 16 (2015): 3089-3102. https://publons.com/publon/4501567/.
    10.1039/C5CE00149H
  49. Harjivan, Shrika G.; Charneira, Catarina; Pereira, Sofia A.; Espadas, Guadalupe; Sabido, Eduard; Beland, Frederick A.; Matilde Marques, M.; Antunes, Alexandra M. M.. "Covalent histone modification by nevirapine: Potential association with non-AIDS defining cancers". Abstracts of Papers of the American Chemical Society 248 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349167406286&KeyUID=WOS:000349167406286.
  50. Grilo, Nadia M.; Batalha, Vania L.; Lopes, Luisa V.; Matilde Marques, M.; Monteiro, Emilia C.; Antunes, Alexandra M. M.; Pereira, Sofia A.. "An animal model to explore efavirenz toxicokinetics and its relation to neurological phenotype". Toxicology Letters 229 (2014): S244-S244. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000341134000762&KeyUID=WOS:000341134000762.
    10.1016/J.TOXLET.2014.06.813
  51. Bandarra, S.; Fernandes, A.S.; Magro, I.; Guerreiro, P.S.; Pingarilho, M.; Churchwell, M.I.; Gil, O.M.; et al. "Erratum: Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells (Mutagenesis (2013) 28:6 (721-729))". Mutagenesis 29 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891367154&partnerID=MN8TOARS.
    10.1093/mutage/get059
  52. Marinho, A.T.; Godinho, A.L.A.; Novais, D.A.; Antunes, A.M.M.; Marques, M.M.; Ramos, T.; Dias, C.G.; et al. "Development and validation of an HPLC-UV method for quantifying nevirapine and its main phase i metabolites in human blood". Analytical Methods 6 5 (2014): 1575-1580. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894120111&partnerID=MN8TOARS.
    10.1039/c3ay41911h
  53. Sofia Pereira; Emília Monteiro; Matilde Marques; Teresa Branco; Umbelina Caixas; Clara Dias; Aline Marinho; Alexandra Antunes. "Sex differences in apolipoprotein A1 and nevirapine-induced toxicity". Journal of the International AIDS Society (2014): https://publons.com/publon/18184289/.
    10.7448/IAS.17.4.19575
  54. Grilo, N.M.; Charneira, C.; Pereira, S.A.; Monteiro, E.C.; Marques, M.M.; Antunes, A.M.M.; Sofia A. Pereira; et al. "Bioactivation to an aldehyde metabolite-Possible role in the onset of toxicity induced by the anti-HIV drug abacavir". Toxicology Letters 224 3 (2014): 416-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890154590&partnerID=MN8TOARS.
    10.1016/j.toxlet.2013.10.036
  55. Sofia A. Pereira; Emília C. Monteiro; M. Matilde Marques; Alexandra M.M. Antunes; Inês Faustino; Umbelina Caixas; Aline T. Marinho; Clara G. Dias. "Thiol status in HIV-infected patients: The effect of nevirapine metabolism". Toxicology Letters (2014): https://publons.com/publon/11121375/.
    10.1016/J.TOXLET.2014.06.352
  56. E. C. Monteiro; S. G. Harjivan; A. M. M. Antunes; A. T. Marinho; S. A. Pereira; M. M. Marques; T. Branco; et al. "Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions". Journal of Antimicrobial Chemotherapy 69 2 (2014): 476-482. https://publons.com/publon/4396368/.
    10.1093/JAC/DKT359
  57. Alexandra M.M. Antunes; M. Matilde Marques; João L. Ferreira da Silva; Riccardo Wanke; Shrika G. Harjivan; Harjivan, S.G.; Wanke, R.; et al. "The phenolic metabolites of the anti-HIV drug efavirenz: Evidence for distinct reactivities upon oxidation with Frémy's salt". European Journal of Medicinal Chemistry 74 (2014): 7-11. https://publons.com/publon/4396381/.
    10.1016/J.EJMECH.2013.12.022
  58. Sofia A. Pereira; Joana P. Miranda; M. Matilde Marques; Emília C. Monteiro; Alexandra M.M. Antunes; Pedro F. Pinheiro; Clara G. Dias; Aline T. Marinho. "PON-1 activity as a protective player in nevirapine hepatotoxicity: Data comparison in 2D and 3D cell cultures". Toxicology Letters (2014): https://publons.com/publon/5063325/.
    10.1016/J.TOXLET.2014.06.476
  59. Matilde F. Castro; Aline T. Marinho; Joana P. Miranda; Sofia A. Pereira; M. Matilde Marques; Alexandra M.M. Antunes; Pedro F. Pinheiro. "Sex differences in hepatic and intestinal contributions for nevirapine biotransformation". Toxicology Letters (2014): https://publons.com/publon/5063382/.
    10.1016/J.TOXLET.2014.06.803
  60. Bandarra, S.; Fernandes, A.S.; Magro, I.; Guerreiro, P.S.; Pingarilho, M.; Churchwell, M.I.; Gil, O.M.; et al. "Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells". Mutagenesis 28 6 (2013): 721-729. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888626357&partnerID=MN8TOARS.
    10.1093/mutage/get052
  61. Beland, F.A.; Mellick, P.W.; Olson, G.R.; Mendoza, M.C.B.; Marques, M.M.; Doerge, D.R.. "Carcinogenicity of acrylamide in B6C3F1 mice and F344/N rats from a 2-year drinking water exposure". Food and Chemical Toxicology 51 1 (2013): 149-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867416800&partnerID=MN8TOARS.
    10.1016/j.fct.2012.09.017
  62. Marques, M. "Estrogen-induced systemic lupus erythematosus: Understanding the role of protein adducts in autoimmunity". Abstracts of Papers of the American Chemical Society (2013): https://publons.com/publon/11121338/.
  63. Alexandra M.M. Antunes; M. Matilde Marques; Sofia A. Pereira; Shrika G. Harjivan; Riccardo Wanke; Wanke, R.; Harjivan, S.G.; et al. "The role of competitive binding to human serum albumin on efavirenz–warfarin interaction: a nuclear magnetic resonance study". International Journal of Antimicrobial Agents 42 5 (2013): 443-446. https://publons.com/publon/4396362/.
    10.1016/J.IJANTIMICAG.2013.06.023
  64. M. Marques; Frederick Beland; M. Oliveira; Benjamin Wolf; Alexandra Antunes; Antunes, A.M.M.; Wolf, B.; et al. "2'-Deoxythymidine Adducts from the Anti-HIV Drug Nevirapine". Molecules 18 5 (2013): 4955-4971. https://publons.com/publon/4396363/.
    10.3390/MOLECULES18054955
  65. Grosse, Yann; Loomis, Dana; Lauby-Secretan, Beatrice; El Ghissassi, Fatiha; Bouvard, Veronique; Benbrahim-Tallaa, Lamia; Guha, Neela; et al. "Carcinogenicity of some drugs and herbal products". Lancet Oncology 14 9 (2013): 807-808.
    10.1016/S1470-2045(13)70329-2
  66. Miranda, J. P.; Pinheiro, P. F.; Marinho, A. T.; Harjivan, S. G.; Castro, M.; Pereira, S. A.; Antunes, A. M. M.; et al. "3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity". Toxicology Letters 221 (2013): S174-S174. https://publons.com/publon/5063334/.
    10.1016/j.toxlet.2013.05.384
  67. Grilo, N.M.; Antunes, A.M.M.; Caixas, U.; Marinho, A.T.; Charneira, C.; Conceição Oliveira, M.; Monteiro, E.C.; et al. "Monitoring abacavir bioactivation in humans: Screening for an aldehyde metabolite". Toxicology Letters 219 1 (2013): 59-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875885900&partnerID=MN8TOARS.
    10.1016/j.toxlet.2013.02.021
  68. Maria de F.C. Matos; M. Matilde Marques; Alexandra M.M. Antunes; Renata T. Perdomo; Danielle Bogo; Camila Santos Suniga Tozatti; James C. Burnett; et al. "Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity". Bioorganic & Medicinal Chemistry Letters 23 16 (2013): 4669-4673. https://publons.com/publon/1458128/.
    10.1016/J.BMCL.2013.06.009
  69. Frederick A. Beland; Igor P. Pogribny; M. Matilde Marques; Linda S. Von Tungeln; Igor Koturbash; William M. Witt; Gonçalo Gamboa da Costa; et al. "Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay". International Journal of Cancer 131 9 (2012): 2008-2015. https://publons.com/publon/11121300/.
    10.1002/IJC.27493
  70. Marques, M. "Binding of the anti-HIV drug Efavirenz to human serum albumin: A F-19-NMR study". Abstracts of Papers of the American Chemical Society (2012): https://publons.com/publon/11121303/.
  71. Marques, M. "Oxidation of phenolic nevirapine metabolites to a reactive quinone - a plausible pathway to toxicity". Abstracts of Papers of the American Chemical Society (2012): https://publons.com/publon/11121312/.
  72. Marques, M. "Hemoglobin adducts from the antiretroviral abacavir in HIV-infected patients as evidence of bioactivation". Abstracts of Papers of the American Chemical Society (2012): https://publons.com/publon/11121320/.
  73. Antunes, A.M.M.; Sidarus, M.; Novais, D.A.; Harjivan, S.G.; Santos, P.P.; Ferreira Da Silva, J.L.; Beland, F.A.; et al. "Oxidation of 2-hydroxynevirapine, a phenolic metabolite of the anti-HIV drug nevirapine: Evidence for an unusual pyridine ring contraction". Molecules 17 3 (2012): 2616-2627. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858980839&partnerID=MN8TOARS.
    10.3390/molecules17032616
  74. Charneira, C.; Grilo, N.M.; Pereira, S.A.; Godinho, A.L.A.; Monteiro, E.C.; Marques, M.M.; Antunes, A.M.M.. "N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo". British Journal of Pharmacology 167 6 (2012): 1353-1361. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867773600&partnerID=MN8TOARS.
    10.1111/j.1476-5381.2012.02079.x
  75. Pereira, S.A.; Wanke, R.; Marques, M.M.; Monteiro, E.C.; Antunes, A.M.M.. "Insights into the role of bioactivation mechanisms in the toxic events elicited by non-nucleoside reverse transcriptase inhibitors". Advances in Molecular Toxicology 6 (2012): 1-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865355478&partnerID=MN8TOARS.
    10.1016/B978-0-444-59389-4.00001-X
  76. Caixas, U.; Antunes, A.M.M.; Marinho, A.T.; Godinho, A.L.A.; Grilo, N.M.; Marques, M.M.; Oliveira, M.C.; et al. "Evidence for nevirapine bioactivation in man: Searching for the first step in the mechanism of nevirapine toxicity". Toxicology 301 1-3 (2012): 33-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864807069&partnerID=MN8TOARS.
    10.1016/j.tox.2012.06.013
  77. Paula S. Branco; M. Matilde Marques; Alice S. Pereira; Filipa Siopa; Luísa Maria Ferreira; Siopa, F.; Pereira, A.S.; et al. "Synthesis of catecholamine conjugates with nitrogen-centered bionucleophiles". Bioorganic Chemistry 44 (2012): 19-24. https://publons.com/publon/10983496/.
    10.1016/J.BIOORG.2012.05.002
  78. Shrika G. Harjivan; Alexandra M. M. Antunes; M. Matilde Marques; David A. Novais; Riccardo Wanke; Wanke, R.; Novais, D.A.; et al. "Biomimetic oxidation of aromatic xenobiotics: synthesis of the phenolic metabolites from the anti-HIV drug efavirenz". Organic & Biomolecular Chemistry 10 23 (2012): 4554-4561. https://publons.com/publon/4396393/.
    10.1039/C2OB25212K
  79. M. Teresa Duarte; André P. Ferreira; J. L. Ferreira da Silva; M. Fátima M. da Piedade; Shrika G. Harjivan; M. Matilde Marques; Ferreira Da Silva, J.L.; et al. "Effect of C–H…X interactions (X = O, S, p) in the supramolecular arrangements of 3-ferrocenyl-methoxybenzo[b]thiophene isomers". CrystEngComm 13 5 (2011): 1638-1645. https://publons.com/publon/11121356/.
    10.1039/C0CE00434K
  80. Charneira, C.; Godinho, A.L.A.; Oliveira, M.C.; Pereira, S.A.; Monteiro, E.C.; Marques, M.M.; Antunes, A.M.M.. "Reactive aldehyde metabolites from the anti-HIV drug abacavir: Amino acid adducts as possible factors in abacavir toxicity". Chemical Research in Toxicology 24 12 (2011): 2129-2141. http://www.scopus.com/inward/record.url?eid=2-s2.0-84055218870&partnerID=MN8TOARS.
    10.1021/tx200337b
  81. Antunes, Alexandra M. M.; Novais, David A.; Ferreira da Silva, J. L.; Santos, Pedro P.; Conceição Oliveira, M.; Beland, Frederick A.; Matilde Marques, M.. "Synthesis and oxidation of 2-hydroxynevirapine, a metabolite of the HIV reverse transcriptase inhibitor nevirapine". Organic & Biomolecular Chemistry 9 22 (2011): 7822. http://dx.doi.org/10.1039/c1ob06052j.
    Publicado • 10.1039/c1ob06052j
  82. Fu, Peter P.; Chou, Ming W.; Churchwell, Mona; Wang, Yuping; Zhao, Yuewei; Xia, Qingsu; Gamboa da Costa, Gonc¸alo; et al. "High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adductsin Vitroandin Vivo". Chemical Research in Toxicology 23 3 (2010): 637-652. http://dx.doi.org/10.1021/tx900402x.
    10.1021/tx900402x
  83. André, V.; Marques, M.M.; Da Piedade, M.F.M.; Duarte, M.T.; M. Matilde Marques; M. Teresa Duarte; M.F. Minas da Piedade; Vânia André. "An ester derivative of the drug gabapentin: PH dependent crystal stability". Journal of Molecular Structure 973 1-3 (2010): 173-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954216808&partnerID=MN8TOARS.
    10.1016/j.molstruc.2010.03.067
  84. Antunes, A.M.M.; Godinho, A.L.A.; Martins, I.L.; Oliveira, M.C.; Gomes, R.A.; Coelho, A.V.; Beland, F.A.; Marques, M.M.. "Protein adducts as prospective biomarkers of nevirapine toxicity". Chemical Research in Toxicology 23 11 (2010): 1714-1725. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649281814&partnerID=MN8TOARS.
    10.1021/tx100186t
  85. Antunes, A.M.M.; Godinho, A.L.A.; Martins, I.L.; Justino, G.C.; Beland, F.A.; Marques, M.M.. "Amino acid adduct formation by the nevirapine metabolite, 12-Hydroxynevirapine- A Possible Factor in Nevirapine Toxicity". Chemical Research in Toxicology 23 5 (2010): 888-899. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952359731&partnerID=MN8TOARS.
    10.1021/tx900443z
  86. Von Tungeln, L.S.; Churchwell, M.I.; Doerge, D.R.; Shaddock, J.G.; McGarrity, L.J.; Heflich, R.H.; Da Costa, G.G.; et al. "DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide". International Journal of Cancer 124 9 (2009): 2006-2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-63449122295&partnerID=MN8TOARS.
    10.1002/ijc.24165
  87. Ferreira, A.P.; Ferreira Da Silva, J.L.; Duarte, M.T.; Fátima Minas Da Piedade, M.; Paula Robalo, M.; Harjivan, S.G.; Marzano, C.; Gandin, V.; Matilde Marques, M.. "Synthesis and characterization of new organometallic benzo[b]thiophene derivatives with potential antitumor properties". Organometallics 28 18 (2009): 5412-5423. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349326103&partnerID=MN8TOARS.
    10.1021/om9003835
  88. José A. L. da Silva; M. Matilde Marques; Ana F. Amaral; Amaral, A.F.; Marques, M.M.; Da Silva, J.A.L.; Fraústo Da Silva, J.J.R.. "Interactions of d-ribose with polyatomic anions, and alkaline and alkaline-earth cations: possible clues to environmental synthesis conditions in the pre-RNA world". New Journal of Chemistry 32 11 (2008): 2043-2049. https://publons.com/publon/11121295/.
    10.1039/B809636H
  89. Antunes, A.M.M.; Duarte, M.P.; Santos, P.P.; Da Costa, G.G.; Heinze, T.M.; Beland, F.A.; Marques, M.M.. "Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine". Chemical Research in Toxicology 21 7 (2008): 1443-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-49049089966&partnerID=MN8TOARS.
    10.1021/tx8000972
  90. J. F. Gaspar; J. Rueff; D. R. Doerge; M. I. Churchwell; F. A. Beland; M. M. Marques; G. Gamboa da Costa; et al. "Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: Correlation with specific glycidamide-DNA adducts". Toxicological Sciences 95 2 (2007): 383-390. https://publons.com/publon/8733556/.
    10.1093/TOXSCI/KFL155
  91. Gamboa da Costa, G.; Marques, M.M.; Fu, X.; Churchwell, M.I.; Wang, Y.-P.; Doerge, D.R.; Beland, F.A.; et al. "Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and a-hydroxytamoxifen". Cancer Letters 257 2 (2007): 191-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-35048822885&partnerID=MN8TOARS.
    10.1016/j.canlet.2007.07.014
  92. Da Costa, G.G.; Pereira, P.C.; Churchwell, M.I.; Beland, F.A.; Marques, M.M.. "DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or a-hydroxytoremifene". Chemical Research in Toxicology 20 2 (2007): 300-310. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947160165&partnerID=MN8TOARS.
    10.1021/tx600275d
  93. David H. Phillips; Gonçalo Gamboa da Costa; M. Matilde Marques; Frederick A. Beland. "Tamoxifen-DNA Adduct Formation in Human Endometrium". Chemical Research in Toxicology (2005): https://publons.com/publon/11121333/.
    10.1021/TX050255W
  94. Vidal, S.T.M.; Correia, M.J.N.; Marques, M.M.; Ismael, M.R.; Reis, M.T.A.. "Studies on the use of ionic liquids as potential extractants of phenolic compounds and metal ions". Separation Science and Technology 39 9 (2004): 2155-2169. http://www.scopus.com/inward/record.url?eid=2-s2.0-3843099317&partnerID=MN8TOARS.
    10.1081/SS-120039311
  95. Alan Hewer; Mona I Churchwell; Frederick A Beland; Gonçalo Gamboa da Costa; M Matilde Marques; David H Phillips; Beland, F.A.; et al. "Analysis of tamoxifen–DNA adducts in endometrial explants by MS and 32 P-postlabeling". Biochemical and Biophysical Research Communications 320 2 (2004): 297-302. https://publons.com/publon/11121272/.
    10.1016/J.BBRC.2004.05.168
  96. Beland, F.A.; Churchwell, M.I.; Doerge, D.R.; Parkin, D.R.; Malejka-Giganti, D.; Hewer, A.; Phillips, D.H.; et al. "Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans". Journal of the National Cancer Institute 96 14 (2004): 1099-1104. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444274918&partnerID=MN8TOARS.
  97. Fonseca, T.; Gigante, B.; Marques, M.M.; Gilchrist, T.L.; De Clercq, E.; Erik De Clercq; Thomas L. Gilchrist; et al. "Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid". Bioorganic and Medicinal Chemistry 12 1 (2004): 103-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346671323&partnerID=MN8TOARS.
    10.1016/j.bmc.2003.10.013
  98. Roberts, D.W.; Doerge, D.R.; Churchwell, M.I.; Da Costa, G.G.; Marques, M.M.; Tolleson, W.H.. "Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover)". Journal of Agricultural and Food Chemistry 52 21 (2004): 6623-6632. http://www.scopus.com/inward/record.url?eid=2-s2.0-6344277277&partnerID=MN8TOARS.
    10.1021/jf049418x
  99. Da Costa, G.G.; Churchwell, M.I.; Hamilton, L.P.; Von Tungeln, L.S.; Beland, F.A.; Marques, M.M.; Doerge, D.R.; et al. "DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice". Chemical Research in Toxicology 16 10 (2003): 1328-1337. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142200904&partnerID=MN8TOARS.
    10.1021/tx034108e
  100. Da Costa, G.G.; Marques, M.M.; Beland, F.A.; Freeman, J.P.; Churchwell, M.I.; Doerge, D.R.. "Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry". Chemical Research in Toxicology 16 3 (2003): 357-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037350190&partnerID=MN8TOARS.
    10.1021/tx020090g
  101. Gamboa da Costa, G.; Marques, M.M.; Freeman, J.P.; Beland, F.A.. "Synthesis and investigation of a-hydroxy-N,N-didesmethyltamoxifen as a proximate carcinogen in the metabolic activation of tamoxifen". Chemical Research in Toxicology 16 9 (2003): 1090-1098. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141625019&partnerID=MN8TOARS.
    10.1021/tx030010o
  102. Schild, L.J.; Divi, R.L.; Beland, F.A.; Churchwell, M.I.; Doerge, D.R.; Da Costa, G.G.; Marques, M.M.; Poirier, M.C.. "Formation of tamoxifen-DNA adducts in multiple organs of adult female cynomolgus monkeys dosed with tamoxifen for 30 days". Cancer Research 63 18 (2003): 5999-6003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141507957&partnerID=MN8TOARS.
  103. Linge Li; Frederick A. Beland; Luísa L. Gonçalves; M. Matilde Marques; Alexandra M. Antunes; Paula S. Branco; M. Paul Chiarelli; et al. "Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadrupole ion trap mass spectrometry". Journal of the American Society for Mass Spectrometry 14 12 (2003): 1488-1492. https://publons.com/publon/4396394/.
    10.1016/J.JASMS.2003.08.009
  104. Chen, T.; Da Costa, G.G.; Marques, M.M.; Shelton, S.D.; Beland, F.A.; Manjanatha, M.G.. "Mutations induced by a-hydroxytamoxifen in the lacI and cII genes of big blue transgenic rats". Carcinogenesis 23 10 (2002): 1751-1757. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036798839&partnerID=MN8TOARS.
  105. Matilde Marques, M.; Gamboa Da Costa, G.; Blankenship, L.R.; Culp, S.J.; Beland, F.A.. "The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 506-507 (2002): 41-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037201540&partnerID=MN8TOARS.
    10.1016/S0027-5107(02)00150-1
  106. Howard, P.C.; Couch, L.H.; Patton, R.E.; Eppley, R.M.; Doerge, D.R.; Churchwell, M.I.; Marques, M.M.; Okerberg, C.V.. "Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F1 mice". Toxicology and Applied Pharmacology 185 3 (2002): 153-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036935316&partnerID=MN8TOARS.
    10.1006/taap.2002.9529
  107. Fang, J.-L.; Beland, F.A.; Doerge, D.R.; Wiener, D.; Guillemette, C.; Marques, M.M.; Lazarus, P.. "Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes". Cancer Research 62 7 (2002): 1978-1986. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036532140&partnerID=MN8TOARS.
  108. Dean W. Roberts; Daniel R. Doerge; M. Matilde Marques; Mona I. Churchwell; William H. Tolleson; Tolleson, W.H.; Doerge, D.R.; et al. "Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro". Journal of Agricultural and Food Chemistry 50 17 (2002): 4783-4790. https://publons.com/publon/11121275/.
    10.1021/JF025549R
  109. Gamboa da Costa, G.; Manjanatha, M.G.; Matilde Marques, M.; Beland, F.A.. "Induction of lacI mutations in Big Blue rats treated with tamoxifen and a-hydroxytamoxifen". Cancer Letters 176 1 (2002): 37-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037039714&partnerID=MN8TOARS.
    10.1016/S0304-3835(01)00741-8
  110. Ritter, C.L.; Culp, S.J.; Freeman, J.P.; Marques, M.M.; Beland, F.A.; Malejka-Giganti, D.; Frederick A. Beland; et al. "DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol". Chemical Research in Toxicology 15 4 (2002): 536-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036223760&partnerID=MN8TOARS.
    10.1021/tx010172p
  111. Gonçalves, L.L.; Beland, F.A.; Marques, M.M.. "Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts". Chemical Research in Toxicology 14 2 (2001): 165-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035101458&partnerID=MN8TOARS.
    10.1021/tx0002031
  112. Gamboa Da Costa, G.; McDaniel-Hamilton, L.P.; Heflich, R.H.; Marques, M.M.; Beland, F.A.. "DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives". Carcinogenesis 22 8 (2001): 1307-1315. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034903983&partnerID=MN8TOARS.
  113. Gamboa Da Costa, G.; Hamilton, L.P.; Beland, F.A.; Marques, M.M.. "Characterization of the major DNA adduct formed by a-hydroxy-N- desmethyltamoxifen in vitro and in vivo". Chemical Research in Toxicology 13 3 (2000): 200-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034122954&partnerID=MN8TOARS.
    10.1021/tx990187b
  114. Santos, M.A.; Afonso, A.; Marques, M.M.; Wilcox, C.. "Molecular Recognition of Acetylaminofluorene- and Aminofluorene-modified Guanosine". Supramolecular Chemistry 11 3 (2000): 201-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034395984&partnerID=MN8TOARS.
  115. Doerge, D.R.; Churchwell, M.I.; Marques, M.M.; Beland, F.A.; Beland FA; Marques MM; Churchwell MI; D. R. Doerge. "Quantitative analysis of 4-aminobiphenyl-C8-deoxyguanosyl DNA adducts produced in vitro and in vivo using HPLC-ES-MS". Carcinogenesis 20 6 (1999): 1055-1061. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032984919&partnerID=MN8TOARS.
    10.1093/carcin/20.6.1055
  116. Beland, F.A.; Doerge, D.R.; Churchwell, M.I.; Poirier, M.C.; Schoket, B.; Marques, M.M.; Mona I. Churchwell; et al. "Synthesis, characterization, and quantitation of a 4-aminobiphenyl-DNA adduct standard". Chemical Research in Toxicology 12 1 (1999): 68-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032943363&partnerID=MN8TOARS.
    10.1021/tx980172y
  117. M. Matilde Marques; Paula S. Branco; Sundaresan Prabhakar; Ana M. Lobo; M. Paul Chiarelli; Alexandra M. M. Antunes; Branco, P.S.; et al. "New syntheses of DNA adducts from methylated anilines present in tobacco smoke". Chemical Research in Toxicology 12 12 (1999): 1223-1233. https://publons.com/publon/4396395/.
    10.1021/TX9901229
  118. Beland, F.A.; McDaniel, L.P.; Marques, M.M.. "Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo". Carcinogenesis 20 3 (1999): 471-477. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033065364&partnerID=MN8TOARS.
  119. Mourato, L.L.G.; Beland, F.A.; Marques, M.M.. "32P-postlabeling of N-(deoxyguanosin-8-yl)arylamine adducts: A comparative study of labeling efficiencies". Chemical Research in Toxicology 12 7 (1999): 661-669. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032588184&partnerID=MN8TOARS.
    10.1021/tx990038t
  120. Howard, P.C.; Churchwell, M.I.; Couch, L.H.; Marques, M.M.; Doerge, D.R.. "Formation of N-(Carboxymethyl)fumonisin B1, Following the Reaction of Fumonisin B1 with Reducing Sugars". Journal of Agricultural and Food Chemistry 46 9 (1998): 3546-3557. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001360367&partnerID=MN8TOARS.
  121. Marques, M.M.; Mourato, L.L.G.; Amorim, M.T.; Santos, M.A.; Melchior Jr., W.B.; Beland, F.A.. "Effect of substitution site upon the oxidation potentials of alkylanilines, the mutagenicities of N-hydroxyalkylanilines, and the conformations of alkylaniline-DNA adducts". Chemical Research in Toxicology 10 11 (1997): 1266-1274. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030819637&partnerID=MN8TOARS.
    10.1021/tx970104w
  122. Beland, F.A.; Melchior Jr., W.B.; Mourato, L.L.G.; Santos, M.A.; Marques, M.M.. "Arylamine-DNA adduct conformation in relation to mutagenesis". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 376 1-2 (1997): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030949281&partnerID=MN8TOARS.
    10.1016/S0027-5107(97)00020-1
  123. Beland FA; M. Marques; Marques, M.M.; Beland, F.A.. "Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide". Carcinogenesis 18 10 (1997): 1949-1954. https://publons.com/publon/11121288/.
    10.1093/CARCIN/18.10.1949
  124. Marques, M.M.; Mourato, L.L.G.; Santos, M.A.; Beland, F.A.. "Synthesis, characterization, and conformational analysis of DNA adducts from methylated anilines present in tobacco smoke". Chemical Research in Toxicology 9 1 (1996): 99-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030034422&partnerID=MN8TOARS.
    10.1021/tx950044z
  125. BELAND, FA; DREW, MG; ESTEVES, MA; FERREIRA, T; MARQUES, MM; SANTOS, MA. "MOLECULAR RECOGNITION OF GUANOSINE AND 2-ACETYLAMINOFLUORENE-MODIFIED GUANOSINE - A COMPARATIVE-STUDY". Supramolecular Chemistry 5 4 (1995): 243-253.
    10.1080/10610279508233951
  126. Dias, A.R.; Duarte, M.T.; Galvão, A.M.; Garcia, M.H.; Marques, M.M.; Salema, M.S.; Masi, D.; Mealli, C.. "Uracil and thiouracil complexes of dicyclopentadienyl molybdenum and tungsten: Preparation and electrochemistry. The structures of [M(¿5-C5H5)2(2-SN 2OC4H3)][PF6], [M(¿5-C5H5)2{2-S(CH 3)N2OC4H2}][PF6],...". Polyhedron 14 5 (1995): 675-685. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038580753&partnerID=MN8TOARS.
    10.1016/0277-5387(94)00288-P
  127. Melchior Jr., W.B.; Marques, M.M.; Beland, F.A.. "Mutations induced by aromatic amine DNA adducts in pBR322". Carcinogenesis 15 5 (1994): 889-899. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027975141&partnerID=MN8TOARS.
    10.1093/carcin/15.5.889
  128. Cho, B.P.; Beland, F.A.; Matilde Marques, M.. "NMR structural studies of a 15-mer DNA duplex from a ras protooncogene modified with the carcinogen 2-aminofluorene: conformational heterogeneity". Biochemistry 33 6 (1994): 1373-1384. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028323638&partnerID=MN8TOARS.
  129. BELAND, FA; CHO, BP; MARQUES, MM. "ONE-DIMENSIONAL MULTIPLE-QUANTUM FILTRATION H-1-NMR SPECTRA OF A 15-MER DNA DUPLEX MODIFIED BY THE CARCINOGEN 4-AMINOBIPHENYL". Magnetic Resonance in Chemistry 31 11 (1993): 1008-1010.
    Publicado • 10.1002/mrc.1260311110
  130. Cho, B.P.; Beland, F.A.; Marques, M.M.. "NMR structural studies of a 15-mer DNA sequence from a ras protooncogene, modified at the first base of codon 61 with the carcinogen 4-aminobiphenyl". Biochemistry 31 40 (1992): 9587-9602. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026795019&partnerID=MN8TOARS.
  131. Marques, M.M.; Beland, F.A.. "Synthesis, characterization, and solution properties of ras sequences modified by arylamine carcinogens at the first base of codon". Chemical Research in Toxicology 3 6 (1990): 559-565. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025253880&partnerID=MN8TOARS.
  132. Poirier MC; Smith BA; Melchior WB Jr; Beland FA; Fullerton NF; M. Matilde Marques. "DNA ADDUCT FORMATION IN RELATION TO TUMORIGENESIS IN MICE CONTINUOUSLY ADMINISTERED 4-AMINOBIPHENYL". Mutation and the Environment, Part A (1990): https://publons.com/publon/19002049/.
  133. Lobo, A.M.; Marques, M.M.; Prabhakar, S.; Rzepa, H.S.. "Tetrahedral intermediates formed by nitrogen and oxygen attack of aromatic hydroxylamines on acetyl cyanide". Journal of Organic Chemistry 52 13 (1987): 2925-2927. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000195484&partnerID=MN8TOARS.
    Publicado
  134. Rzepa, H.S.; Lobo, A.M.; Matilde Marques, M.; Prabhakar, S.. "Characterizing a tetrahedral intermediate in an acyl transfer reaction: An undergraduate 1 H NMR demonstration". Journrl of Chemical Education 64 8 (1987): 725-726. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845281927&partnerID=MN8TOARS.
    Publicado
  135. PRABHAKAR, S.; LOBO, A. M.; MARQUES, M. M.. "A New Synthesis of the Amaryllidaceae Alkaloid Hippadine". Journal of Chemical Research (1987): 167-167. http://dx.doi.org/10.1002/chin.198740351.
    Publicado • 10.1002/chin.198740351
  136. PRABHAKAR, S.; LOBO, A. M.; MARQUES, M. M.; TAVARES, M. R.. "A Synthesis of the Alkaloid Ismine". Chemischer Informationsdienst 17 15 (1986): http://dx.doi.org/10.1002/chin.198615355.
    10.1002/chin.198615355
  137. Lobo, A.M.; Marques, M.M.; Prabhakar, S.; Rzepa, H.S.. "Tetrahedral intermediates formed during acyl transfer. Reactions of acetyl cyanide". Journal of the Chemical Society, Chemical Communications 16 (1985): 1113-1115. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049105414&partnerID=MN8TOARS.
    Publicado
  138. LOBO, AM; MARQUES, MM; PRABHAKAR, S. "REACTIONS BETWEEN HYDROXYLAMINES AND AROYL CYANIDES". Tetrahedron Letters 23 13 (1982): 1391-1394.
    Publicado • 10.1016/S0040-4039(00)87114-2
Capítulo de livro
  1. Beland, F. A.; Camacho L; Marques, M Matilde. "Polycyclic Aromatic Hydrocarbons, Methylated Polycyclic Aromatic Hydrocarbons, and Polycyclic Azaaromatic Compounds". In Patty's Toxicology, editado por Paustenbach DJ; Farland DH; Klaunig J; Levy L. New York, Estados Unidos: John Wiley & Sons, Inc, 2024.
    No prelo
  2. Cátia F. Marques; Marques, M Matilde. "Pharmacometabolomics in Drug Discovery and Development". In Systems Medicine: Integrative, Qualitative and Computational Approaches. Elsevier, 2020.
    No prelo
  3. Marques, M Matilde; Beland, F.A.. "Aromatic amines and aristolochic acids Tumour Site Concordance and Mechanisms of Carcinogenesis". In Tumour Site Concordance and Mechanisms of Carcinogenesis - IARC Scientific Publication, editado por Baan, R. A.; Stewart, B. W.; Straif, K., 23-30. Lyon, França: International Agency for Research on Cancer, 2019.
    Publicado
  4. Beland, F.A.; Marques, M.M.. "DNA adducts of nitropolycyclic aromatic hydrocarbons.". In IARC scientific publications, 229-244. 1994.
  5. Marques, M.M.; Beland, F.A.. "DNA adducts of aromatic amines present in tobacco smoke.". In IARC scientific publications, 453-456. 1994.
Livro
  1. Allen, N.; Anderson, L.M.; Beland, F.A.; Bénichou, J.; Beral, V.; Bloomfield, K.; Brooks, P.J.; et al. Alcohol consumption and ethyl carbamate. 2010.
Resumo em conferência
  1. M. Matilde Marques; ALA Godinho; MC Oliveira; SA Pereira; EC Monteiro; FA Beland; AMM Antunes. "Mass spectrometric detection of hemoglobin adducts from the anti-HIV drug nevirapine and its metabolite 12-hydroxy-nevirapine in rats". Trabalho apresentado em ACS National Meeting, Boston, 2010.
    Publicado
  2. M.M. Marques; C. Charneira; A.M. Antunes. "Protein adduct formation: A possible factor in hypersensitivity reactions induced by the anti HIV drug abacavir". Trabalho apresentado em IUTOX2010, Barcelona, 2010.
    Publicado • 10.1016/J.TOXLET.2010.03.390
  3. M. Matilde Marques; Alexandra M.M. Antunes; Muna C. Sidarus; Frederick A. Beland. "Chemical and enzymatic oxidation of 2-hydroxynevirapine, a metabolite of the HIV-1 reverse transcriptase inhibitor nevirapine". Trabalho apresentado em Eurotox2009, Dresden, 2009.
    Publicado • 10.1016/J.TOXLET.2009.06.333
  4. Alexandra M.M. Antunes; Ana Godinho; M. Matilde Marques; Inês Martins; Frederick A. Beland. "Protein adduct formation by the nevirapine metabolite, 12-hydroxynevirapine—A possible factor in nevirapine toxicity". Trabalho apresentado em Eurotox2009, Dresden, 2009.
    Publicado • 10.1016/J.TOXLET.2009.06.334

Outros

Outra produção
  1. Bitumens and bitumen emissions, and some heterocyclic polycyclic aromatic hydrocarbons. 2011. Lauby-Secretan, B; Baan, R; Grosse, Y; El Ghissassi, F; Bouvard, V; Benbrahim-Talla, L; Guha, N; et al.
    10.1016/S1470-2045(11)70359-X
  2. A review of human carcinogens—Part A: pharmaceuticals. 2009. Grosse, Y; Baan, R; Straif, K; Secretan, B; El Ghissassi, F.; Bouvard, V; Benbrahim-Tallaa, L; et al.
    10.1016/S1470-2045(08)70286-9
  3. Carcinogenicity of alcoholic beverages. 2007. Baan, R; Straif, K; Grosse, Y; Secretan, B; El Ghissassi, F; Bouvard, V; Altieri, A; Cogliano, V; the WHO International Agency for Research on Cancer Monograph Working Group.
    10.1016/S1470-2045(07)70099-2
  4. Carcinogenicity of Polycyclic Aromatic Hydrocarbons. 2005. Straif, K; Baan, R; Grosse, Y; Secretan, B; El Ghissassi, F; Cogliano, V; the WHO International Agency for Research on Cancer Monograph Working Group. http://dx.doi.org/10.1016/S1470-2045(05)70458-7.
    10.1016/S1470-2045(05)70458-7
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - 2025 Overcoming ß-lactam antibiotics resistance in methicillinresistant Staphylococcus aureus – Targeting penicillin-binding protein 2a
Coorientador
 Chemistry (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023 - 2023 Synthesis and biological evaluation of new molecular entities with the potential to overcome ß-lactam antibiotics resistance in methicillin-resistant Staphyloccocus aureus (MRSA)
Coorientador
 Ciência e Engenharia Moleculares (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2022/12 Toxicological and mechanistic evaluation behind Montelukast repurposing: metabolomic and proteomic approaches
Orientador
 Química (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022 - 2022 Targeting the “undruggable”: a combinatorial platform for the discovery of peptidomimetic covalent inhibitors of protein-protein interactions
Coorientador
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/02/01 - 2021/10/31 The natural killer cell activation compound 815A: solubility, stability, and injectable formulations, Engenharia Farmacêutica, IST (concluído 2021
Coorientador
 Pharmaceutical Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2020 An epigenetic approach to anticancer therapy: Design, synthesis and biological evaluation of novel EZH2 inhibitors
Orientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2020 Targeting glucose metabolism for cancer treatment: dual inhibition of hexokinase II
Orientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2020 Triggering a specific immune response against cancer – a strategy for primary and metastatic tumor treatment
Orientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018 Chemical Proteomics: mass spectrometry-based label-free quantitative approach in cell systems
Coorientador
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018 Development of a bacterial model for the production of functional human drug metabolizing enzymes
Coorientador
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018 Síntese e caracterização de biomarcadores da etil vinil cetona
Orientador
 Biotecnologia (Licenciatura/Bacharelato)
Instituto Politécnico de Setúbal Escola Superior de Tecnologia do Barreiro, Portugal
2016 - 2018 Synthesis and assessment of novel thiazolopyrimidine derivatives with prospective biological activity
Coorientador
 Chemistry (Doutoramento)
South Valley University Faculty of Science, Egipto
2011 - 2018 Desenvolvimento de novos biomarcadores de toxicidade dos fármacos carbamazepina e oxcarbazepina
Coorientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Development of separation methods for Botulinum neurotoxins, using a statistical modelling-based approach
Coorientador
 Engenharia Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Síntese e caracterização de biomarcadores da metil vinil cetona
Orientador
 Biotecnologia (Licenciatura/Bacharelato)
Instituto Politécnico de Setúbal Escola Superior de Tecnologia do Barreiro, Portugal
2012 - 2017 CHEMICAL MODIFICATION OF BIONUCLEOPHILES BY NNRTI METABOLITES: A MOLECULAR BASIS FOR NON-AIDS DEFINING CANCERS AND OTHER TOXIC EFFECTS?
Orientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2017 Estratégias in vitro e in vivo para o estudo da bioativação do fármaco anti-HIV etravirina
Coorientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Estudos de Reactividade de Metabolitos do Fármaco Antiplaquetário Clopidogrel
Coorientador
 Engenharia Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015 Proteção de fármacos oxidáveis: formulação e processo
Coorientador
 Engenharia Farmacêutica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015 Garantia e Controlo da Qualidade na Validação de Processo de fabrico de Pó para Suspensão Oral Extemporânea
Coorientador
 Engenharia Farmacêutica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015 Estudos de Estabilidade de Formas Farmacêuticas HPLC e controlo microbiológico
Coorientador
 Engenharia Farmacêutica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015 Development of a method of extraction and quantification of polycyclic aromatic hydrocarbons from a bituminous matrix
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015 Activação de aloe emodina a espécies electrófilas. Potencial relação com a carcinogenicidade de Aloe barbadensis Miller
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2012 Síntese estereoselectiva de hidroxi ciclopentenaminas e ciclohexenaminas a partir das respectivas cicloenonas
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2012 A first total synthesis of (L)-erythro-ceramide C6 from natural (L)-serine
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2012 New approach for synthesis of biologically active chiral 5-substituted tetrazoles
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2011 Estudo do sistema catalítico de oxidação com ácido p-toluenosulfónico/peróxido de hidrogénio aplicado ao ciclohexadieno e ao dibenzotiofeno
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2011 Extracção selectiva do ácido labdanólico de extracto natural utilizando polímeros molecularmente impressos
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2011 Modificação de proteínas e DNA por quinonas derivadas de catecolaminas
Coorientador
 Química (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2011 Síntese e avaliação biológica de análogos da combrestatina A-4 com os átomos de enxofre e selénio como grupos espaçadores
Coorientador
 Química (Doutoramento)
Universidade Federal de Mato Grosso do Sul, Brasil
2010 - 2010 Synthesis of chemically modified oligonucleotides: An approach to orthogonal modification
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009 - 2009 Synthesis and characterization of deoxythymidine adducts from the HIV reverse transcriptase inhibitor nevirapine
Coorientador
 Química (Iniciação científica)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2009 Análise de adutos de aminoácidos com o fármaco nevirapina por LC-ESI-MS
Coorientador
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2008 Síntese de um peptidoglicano bacteriano reconhecido pelo sistema imunitário
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2008 Synthesis of organometallic compounds with potencial therapeutic properties
Orientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2008 Design, synthesis and testing of new Ras inhibitors: nucleotide exchange inhibition as a novel approach
Coorientador
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2008 Os ácidos hidrocinâmicos como precursores de fenóis voláteis em vinhos tintos
Coorientador
 Engenharia Química - Química Aplicada (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2007 New studies on ionic liquids
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2007 Validação de métodos de detecção de drogas de abuso por GC/MS. Avaliação de Robustez
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2007 Boro: um elemento fundamental nos primórdios da vida na terra?
Coorientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2007 Estudos de oxidação da 2-hidroxi-nevirapina, metabolito do fármaco anti-HIV nevirapina
Orientador
 Química (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2005 - 2005 Desenvolvimento e validação de um método de quantificação de opiáceos em urina humana por HPLC-UV/DAD
Coorientador
 Química (Licenciatura/Bacharelato)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2004 - 2004 Separação e identificação de polissacáridos presentes em aglutinantes e encolagens por HPLC-PDA
Coorientador
 Engenharia Química (Outra)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2004 - 2004 Estudos sobre o HES no âmbito do controlo antidopagem
Coorientador
 Química (Outra)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2001 - 2002 Síntese de líquidos iónicos e avaliação do seu potencial em processos de extracção líquido-líquido
Coorientador
Universidade de Lisboa Instituto Superior Técnico, Portugal
1998 - 2002 Interacção do ADN com Metabolitos do Tamoxifen - Síntese, Quantificação e Avaliação Mutagénica de Adutos Covalentes
Orientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2000 - 2001 Síntese de compostos do tipo ß-halo- a-hidroxitamoxifen
Orientador
Universidade de Lisboa Instituto Superior Técnico, Portugal
1998 - 2001 Synthesis of Heterocycles Derived from Dehydroabietic Acid
Coorientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1995 - 2000 Adutos ADN-monoarilamina: Síntese, Caracterização e Estudos de Pós-marcação com Fósforo-32
Orientador
 Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1997 - 1998 Síntese e reactividade de metabolitos do tamoxifen
Orientador
 Química Orgânica e Tecnológica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1992 - 1994 Estudos de modificação química da 2'-desoxiguanosina com aminas aromáticas
Orientador
 Engenharia Química - Química Aplicada (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1991 - 1992 Síntese de uracilos metilados
Coorientador
 Engenharia Química (Outra)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - Atual Pharmaceuticals MDPI
2008 - 2022 Chemical Research in Toxicology American Chemical Society
2011 - 2014 ISRN Toxicology (2090-6196) Hindawi (International Scholarly Research Network)
2001 - 2003 Chemical Research in Toxicology American Chemical Society

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2021/01 - 2021 Grant Application Reviewer, New York University Abu Dhabi
Avaliador
 New York University - Abu Dhabi Campus, Emiratos Árabes Unidos

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2008 - Atual Technical Arbitrary Court Assistant in multiple Intellectual Property Litigations on Pharmaceutical Products

Membro de associação

Nome da associação Tipo de participação
2016 - Atual Royal Society of Chemistry
2011 - Atual Sociedade Portuguesa de Química
1998 - Atual American Chemical Society
1990 - Atual American Association for Cancer Research

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021/01 - Atual Executive Committee, Division of Chemical Toxicology, American Chemical Society (Elected)
2020 - Atual IUPAC Subcommittee on Toxicology and Risk Assessment
Membro
 International Union of Pure and Applied Chemistry, Estados Unidos
2019 - Atual ESF College of Expert Reviewers European Science Foundation, França
2023/06/06 - 2023/06/13 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 134: Aspartame, Methyleugenol, and Isoeugenol Chair, Mechanisms subgroup
Membro
 International Agency for Research on Cancer Group IARC Monographs, França
2020/10/29 - 2020/11/13 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 128: Acrolein, Crotonaldehyde, and Arecoline (Chair)
Outro
 International Agency for Research on Cancer, França
2017 - 2020 Division of Medicinal Chemistry SPQ
Presidente / Vice-presidente
 Sociedade Portuguesa de Química, Portugal
2017 - 2020 Council member, EFMC
Membro
 European Federation for Medicinal Chemistry, Bélgica
2019 - 2019 Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024 (Chair)
Coordenador
 International Agency for Research on Cancer, França
2018 - 2018 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 122 Chair, Mechanisms subgroup)
Membro
 International Agency for Research on Cancer, França
2015 - 2017 Alternative Councilor (elected), Division of Chemical Toxicology
Outro
 American Chemical Society, Estados Unidos
2016 - 2016 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 115
Membro
 International Agency for Research on Cancer, França
2013 - 2013 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 108 (Chair, Mechanisms Subgroup)
Membro
 International Agency for Research on Cancer, França
2011 - 2011 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 103
Membro
 International Agency for Research on Cancer, França
2008 - 2008 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 100A (co-chair, Mechanisms subgroup)
Membro
 International Agency for Research on Cancer, França
2008 - 2008 Working Group, Acrylamide carcinogenicity new evidence in relation to dietary exposure
Membro
 European Food Safety Authority, Itália
2007 - 2007 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 96
Membro
 International Agency for Research on Cancer, França
2005 - 2005 Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 92
Membro
 International Agency for Research on Cancer, França

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2021 - Atual Young Investigator Award, Chemical Research in Toxicology
1988 - Atual Reviewer for > 50 scientific journals listed in the Web of Knowledge database
2023/09 - 2023/10 Grant application reviewer, National Science Centre Poland, OPUS-25 Narodowe Centrum Nauki, Polónia
2023/05 - 2023/05 Post-doctoral grant applications, Genopole-ApogeeBio-2023 Genopole, França
2022 - 2022 Grant Application Remote Reviewer, ERC Advanced Grant 2021 European Research Council, Bélgica
2022 - 2022 Postdoctoral Grant Application Reviewer, FWO, Belgium Fonds Wetenschappelijk Onderzoek Vlaanderen, Bélgica
2017 - 2017 Young Investigator Award Committee EFMC European Federation for Medicinal Chemistry, Bélgica
2016 - 2016 Grant application reviewer, generic call, Agence Nationale de la Recherche Agence nationale de la recherche, França
2014 - 2016 Application reviewer, Pfizer/ Sociedade de Ciências Médicas de Lisboa Award in Basic Research Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal
2014 - 2015 Young Investigator Award Committee, Division of Chemical Toxicology American Chemical Society, Estados Unidos
2013 - 2013 Grant reviewer, ERC Advanced Grant European Research Council, Bélgica
2011 - 2012 TOXI Awards Committee (Founders Award and ACS Fellows Program), Division of Chemical Toxicology American Chemical Society, Estados Unidos
2007 - 2007 Grant reviewer, Post-doctoral fellowship applications, FCT Fundação para a Ciência e a Tecnologia, Portugal
2004 - 2004 PhD fellowship appplication, Fundação Oriente Fundação Oriente, Portugal
2001 - 2001 Grant reviewer, Programa Gulbenkian de Estímulo à Investigação, Chemical Synthesis Fundação Calouste Gulbenkian, Portugal