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Sílvia Cristina da Cruz Marques Socorro, é Professora Catedrática de Biomedicina na Universidade da Beira Interior. É Coordenadora do CICS-UBI, Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior. Publicou dezenas de artigos em revistas especializadas na área da biologia celular e molecular, reprodução e cancro. Possui vários capítulos de livros publicados e a edição de um livro. Os interesses de investigação abrangem a ação das hormonas esteróides sexuais (e desreguladores endócrinos) no controlo da sobrevivência celular, metabolismo energético e homeostasia do cálcio na reprodução masculina e cancro da próstata.
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Identificação

Identificação pessoal

Nome completo
Sílvia Cristina da Cruz Marques Socorro

Nomes de citação

  • Socorro, Sílvia

Identificadores de autor

Ciência ID
AB17-5C25-1F2C
ORCID iD
0000-0001-8181-488X
Google Scholar ID
https://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
Researcher Id
G-2285-2010
Scopus Author Id
23097994600

Endereços de correio eletrónico

  • ssocorro@fcsaude.ubi.pt (Profissional)

Telefones

Telefone
  • 275329053 (Profissional)

Moradas

  • Universidade da Beira Interior, Faculdade de Ciências da Saúde. Av. Infante D. Henrique , 6200-506, Covilhã, Covilhã, Portugal (Profissional)

Websites

  • http://www.cics.ubi.pt/Investigador/629 (Profissional)
  • http://orcid.org/0000-0001-8181-488X (Profissional)
  • https://www.ubi.pt/Pessoa/silvia (Académico)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2013
Concluído
 Biomedicina (Título de Agregado)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2001
Concluído
 Ciências Biológicas (Doutoramento)
Universidade do Algarve, Portugal
"Cloning and characterisation of seabream (Sparus aurata) estrogen receptors." (TESE/DISSERTAÇÃO)
1994
Concluído
 Biologia Marinha (Licenciatura)
Universidade do Algarve, Portugal
"Estimulação por esteróides e gonadotrofina da maturação final in vitro de ovócitos em Halobatrachus didactylus. " (TESE/DISSERTAÇÃO)
 17
Percurso profissional

Ciência

2002 - Atual Investigador (Investigação)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2001 - 2002 Investigador Auxiliar Convidado (carreira) (Investigação)
Universidade do Algarve, Portugal
2001 - 2001 Investigador Auxiliar Convidado (carreira) (Investigação)
Ottawa Health Research Institute, Ottawa Hospita, Canadá
1994 - 2000 Investigador (Investigação)
Universidade do Algarve, Portugal

Docência no Ensino Superior

2019 - Atual Professor Catedrático (Docente Universitário)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2016/10/01 - 2019 Professor Associado (Docente Universitário)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2004 - 2013 Professor Auxiliar (Docente Universitário)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2002 - 2004 Professor Auxiliar Convidado (Docente Universitário)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Projetos

Bolsa

Designação Financiadores
2001 - 2002 Genes and sex change: steroid receptors and novel genes in seabream (Sparus aurata)
BPD/7129/2001
Bolseiro de Pós-Doutoramento
Ministério da Ciência Tecnologia e Ensino Superior
1996 - 2000 Cloning and characterisation of seabream (Sparus aurata) estrogen receptors.
BD/9214/96
Bolseiro de Doutoramento
Ministério da Ciência Tecnologia e Ensino Superior

Projeto

Designação Financiadores
2018 - Atual Shaping prostate cell metabolism by extrinsic factors: insights into cancer prevention, diagnosis and treatment
POCI-01-0145-FEDER-029114
Investigador responsável
Fundação para a Ciência e a Tecnologia
2016 - Atual "Tribbles Research and Innovation Network (TRAIN)"
EU project 721532
Investigador responsável
European Commission
2013 - 2015 Hormonal and Inflammatory basis of age-related diseases
CENTRO-07-ST24-FEDER-002015
Investigador
Comissão de Coordenação e Desenvolvimento Regional do Centro, Programa Operacional Regional do Centro 2007-2013 QREN
2012 - 2015 Can Hormonal (De)regulation of Ion Transporters in Human Sertoli Cells be Responsible for Infertility?
121446
Provided by PTCRIS: 121446
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2008/08 Regulation of human and mouse transthyretin levels in liver and choroid plexus by steroid hormones.
55380
Provided by PTCRIS: 55380
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Henrique J. Cardoso; Marília I. Figueira; Cátia V. Vaz; Tiago M. A. Carvalho; Luís A. Brás; Patrícia A. Madureira; Paulo J. Oliveira; Vilma A. Sardão; Sílvia Socorro. "Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5a-dihydrotestosterone regulation". Cellular Oncology (2021): https://doi.org/10.1007/s13402-020-00575-9.
    10.1007/s13402-020-00575-9
  2. Henrique J. Cardoso; Tiago M. A. Carvalho; Lara R. S. Fonseca; Marília I. Figueira; Cátia V. Vaz; Sílvia Socorro. "Revisiting prostate cancer metabolism: From metabolites to disease and therapy". Medicinal Research Reviews (2020): https://doi.org/10.1002/med.21766.
    10.1002/med.21766
  3. Silva, Gonçalo R.; Vaz, Cátia V.; Catalão, Beatriz; Ferreira, Susana; Cardoso, Henrique J.; Duarte, Ana Paula; Socorro, Sílvia. "Sweet Cherry Extract Targets the Hallmarks of Cancer in Prostate Cells: Diminished Viability, Increased Apoptosis and Suppressed Glycolytic Metabolism". Nutrition and Cancer 11 (2019): 1-15. http://dx.doi.org/10.1080/01635581.2019.1661502.
    Publicado • 10.1080/01635581.2019.1661502
  4. Tiago MA. Carvalho; Henrique J. Cardoso; Marília I. Figueira; Cátia V. Vaz; Sílvia Socorro. "The peculiarities of cancer cell metabolism: A route to metastasization and a target for therapy". European Journal of Medicinal Chemistry 171 (2019): 343-363. https://doi.org/10.1016/j.ejmech.2019.03.053.
    10.1016/j.ejmech.2019.03.053
  5. Henrique J. Cardoso; Cátia V. Vaz; Tiago M.A. Carvalho; Marília I. Figueira; Sílvia Socorro. "Tyrosine kinase inhibitor imatinib modulates the viability and apoptosis of castrate-resistant prostate cancer cells dependently on the glycolytic environment". Life Sciences 218 (2019): 274-283. https://doi.org/10.1016/j.lfs.2018.12.055.
    10.1016/j.lfs.2018.12.055
  6. Inês Mateus; Mariana Feijó; Luís M. Espínola; Cátia V. Vaz; Sara Correia; Sílvia Socorro. "Glucose and glutamine handling in the Sertoli cells of transgenic rats overexpressing regucalcin: plasticity towards lactate production". Scientific Reports (2018): https://doi.org/10.1038/s41598-018-28668-4.
    10.1038/s41598-018-28668-4
  7. Henrique J. Cardoso; Marília I. Figueira; Sílvia Socorro. "The stem cell factor (SCF)/c-KIT signalling in testis and prostate cancer". Journal of Cell Communication and Signaling (2017): https://doi.org/10.1007/s12079-017-0399-1.
    10.1007/s12079-017-0399-1
  8. Marília I. Figueira; Henrique J. Cardoso; Sara Correia; Cláudio J. Maia; Sílvia Socorro. "The stem cell factor (SCF)/c-KIT system in carcinogenesis of reproductive tissues: What does the hormonal regulation tell us?". Cancer Letters 405 (2017): 10-21. https://doi.org/10.1016%2Fj.canlet.2017.07.017.
    10.1016/j.canlet.2017.07.017
  9. Correia, S.; Vaz, C.V.; Silva, A.M.S.; Cavaco, J.E.; Socorro, S.. "Regucalcin counteracts tert-butyl hydroperoxide and cadmium-induced oxidative stress in rat testis". Journal of Applied Toxicology 37 2 (2017): 159-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002396873&partnerID=MN8TOARS.
    10.1002/jat.3333
  10. Figueira, M.I.; Correia, S.; Vaz, C.V.; Cardoso, H.J.; Gomes, I.M.; Marques, R.; Maia, C.J.; Socorro, S.. "Estrogens down-regulate the stem cell factor (SCF)/c-KIT system in prostate cells: Evidence of antiproliferative and proapoptotic effects". Biochemical Pharmacology 99 (2016): 73-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952638603&partnerID=MN8TOARS.
    10.1016/j.bcp.2015.11.016
  11. Vaz, C.V.; Marques, R.; Cardoso, H.J.; Maia, C.J.; Socorro, S.. "Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation". Transgenic Research 25 2 (2016): 139-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946811164&partnerID=MN8TOARS.
    10.1007/s11248-015-9918-0
  12. Silva, A.M.S.; Correia, S.; Socorro, S.; Maia, C.J.. "Endogenous factors in the recovery of reproductive function after testicular injury and cancer". Current Molecular Medicine 16 7 (2016): 631-649. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989247286&partnerID=MN8TOARS.
    10.2174/1566524016666160802150400
  13. Silva, A.M.S.; Correia, S.; Casalta-Lopes, J.E.; Mamede, A.C.; Cavaco, J.E.B.; Botelho, M.F.; Socorro, S.; Maia, C.J.. "The protective effect of regucalcin against radiation-induced damage in testicular cells". Life Sciences 164 (2016): 31-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987923505&partnerID=MN8TOARS.
    10.1016/j.lfs.2016.09.003
  14. Vaz, C.V.; Correia, S.; Cardoso, H.J.; Figueira, M.I.; Marques, R.; Maia, C.J.; Socorro, S.. "The emerging role of regucalcin as a tumor suppressor: Facts and views". Current Molecular Medicine 16 7 (2016): 607-619. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989246357&partnerID=MN8TOARS.
    10.2174/1566524016666160714124550
  15. Cátia V. Vaz; Ricardo Marques; Cláudio J. Maia; Sílvia Socorro. "Aging-associated changes in oxidative stress, cell proliferation, and apoptosis are prevented in the prostate of transgenic rats overexpressing regucalcin". Translational Research 166 6 (2015): 693-705. https://doi.org/10.1016/j.trsl.2015.08.009.
    10.1016/j.trsl.2015.08.009
  16. Marques, R.; Vaz, C.V.; Maia, C.J.; Gomes, M.; Gama, A.; Alves, G.; Santos, C.R.; Schmitt, F.; Socorro, S.. "Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis". Experimental Cell Research 330 2 (2015): 325-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919789386&partnerID=MN8TOARS.
    10.1016/j.yexcr.2014.08.007
  17. Correia, S.; Cardoso, H.J.; Cavaco, J.E.; Socorro, S.. "Oestrogens as apoptosis regulators in mammalian testis: Angels or devils?". Expert Reviews in Molecular Medicine 17 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927716482&partnerID=MN8TOARS.
    10.1017/erm.2014.25
  18. Gonçalves, C.; Bastos, M.; Pignatelli, D.; Borges, T.; Aragüés, J.M.; Fonseca, F.; Pereira, B.D.; Socorro, S.; Lemos, M.C.. "Novel FGFR1 mutations in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism: Evidence for the involvement of an alternatively spliced isoform". Fertility and Sterility (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940748757&partnerID=MN8TOARS.
    10.1016/j.fertnstert.2015.07.1142
  19. Vaz, C.V.; Marques, R.; Alves, M.G.; Oliveira, P.F.; Cavaco, J.E.; Maia, C.J.; Socorro, S.. "Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes". Journal of Cancer Research and Clinical Oncology (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930532325&partnerID=MN8TOARS.
    10.1007/s00432-015-1992-4
  20. Cardoso, H.J.; Vaz, C.V.; Correia, S.; Figueira, M.I.; Marques, R.; Maia, C.J.; Socorro, S.. "Paradoxical and contradictory effects of imatinib in two cell line models of hormone-refractory prostate cancer". Prostate 75 9 (2015): 923-935. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929996402&partnerID=MN8TOARS.
    10.1002/pros.22976
  21. Marques, R.; Peres, C.G.; Vaz, C.V.; Gomes, I.M.; Figueira, M.I.; Cairrão, E.; Verde, I.; Maia, C.J.; Socorro, S.. "5a-Dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth". Medical Oncology 32 9 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84938787084&partnerID=MN8TOARS.
    10.1007/s12032-015-0676-x
  22. Vaz, C.V.; Rodrigues, D.B.; Socorro, S.; Maia, C.J.. "Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells". Biochimica et Biophysica Acta - Molecular Cell Research 1853 10 (2015): 2621-2628. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939454739&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2015.07.006
  23. Dias, T.R.; Alves, M.G.; Tomás, G.D.; Socorro, S.; Silva, B.M.; Oliveira, P.F.. "White tea as a promising antioxidant medium additive for sperm storage at room temperature: A comparative study with green tea". Journal of Agricultural and Food Chemistry 62 3 (2014): 608-617. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892999479&partnerID=MN8TOARS.
    10.1021/jf4049462
  24. Cardoso, H.J.; Figueira, M.I.; Correia, S.; Vaz, C.V.; Socorro, S.. "The SCF/c-KIT system in the male: Survival strategies in fertility and cancer". Molecular Reproduction and Development 81 12 (2014): 1064-1079. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920051800&partnerID=MN8TOARS.
    10.1002/mrd.22430
  25. Correia, S.; Alves, M.G.; Oliveira, P.F.; Alves, M.R.; van Pelt, A.M.M.; Cavaco, J.E.; Socorro, S.. "Transgenic overexpression of regucalcin leads to suppression of thapsigargin- and actinomycin D-induced apoptosis in the testis by modulation of apoptotic pathways". Andrology 2 2 (2014): 290-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894308909&partnerID=MN8TOARS.
    10.1111/j.2047-2927.2014.00186.x
  26. Oliveira, P.F.; Alves, M.G.; Martins, A.D.; Correia, S.; Bernardino, R.L.; Silva, J.; Barros, A.; et al. "Expression pattern of G protein-coupled receptor 30 in human seminiferous tubular cells". General and Comparative Endocrinology 201 (2014): 16-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897952706&partnerID=MN8TOARS.
    10.1016/j.ygcen.2014.02.022
  27. Figueira, M.I.; Cardoso, H.J.; Correia, S.; Maia, C.J.; Socorro, S.. "Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?". Progress in histochemistry and cytochemistry 49 1-3 (2014): 1-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919473944&partnerID=MN8TOARS.
    10.1016/j.proghi.2014.09.001
  28. Correia, S.; Alves, M.R.; Cavaco, J.E.; Oliveira, P.F.; Socorro, S.. "Estrogenic regulation of testicular expression of stem cell factor and c-kit: Implications in germ cell survival and male fertility". Fertility and Sterility 102 1 (2014): 299-306. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903381688&partnerID=MN8TOARS.
    10.1016/j.fertnstert.2014.04.009
  29. Vaz, C.V.; Maia, C.J.; Marques, R.; Gomes, I.M.; Correia, S.; Alves, M.G.; Cavaco, J.E.; Oliveira, P.F.; Socorro, S.. "Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways". Prostate 74 12 (2014): 1189-1198. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904658283&partnerID=MN8TOARS.
    10.1002/pros.22835
  30. Marques, R.; Maia, C.J.; Vaz, C.; Correia, S.; Socorro, S.. "The diverse roles of calcium-binding protein regucalcin in cell biology: From tissue expression and signalling to disease". Cellular and Molecular Life Sciences 71 1 (2014): 93-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891882606&partnerID=MN8TOARS.
    10.1007/s00018-013-1323-3
  31. Alves, M.G.; Martins, A.D.; Vaz, C.V.; Correia, S.; Moreira, P.I.; Oliveira, P.F.; Socorro, S.. "Metformin and male reproduction: Effects on Sertoli cell metabolism". British Journal of Pharmacology 171 4 (2014): 1033-1042. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893042451&partnerID=MN8TOARS.
    10.1111/bph.12522
  32. Rato, L.; Duarte, A.I.; Tomás, G.D.; Santos, M.S.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Alves, M.G.; Oliveira, P.F.. "Pre-diabetes alters testicular PGC1-a/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress". Biochimica et Biophysica Acta - Bioenergetics 1837 3 (2014): 335-344. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892411578&partnerID=MN8TOARS.
    10.1016/j.bbabio.2013.12.008
  33. Martins, A.D.; Alves, M.G.; Simões, V.L.; Dias, T.R.; Rato, L.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Oliveira, P.F.. "Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes". Cell and Tissue Research 354 3 (2013): 861-868. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890482473&partnerID=MN8TOARS.
    10.1007/s00441-013-1722-7
  34. Gärtner, A.; Pereira, T.; Alves, M.G.; Armada-da-Silva, P.A.S.; Amorim, I.; Gomes, R.; Ribeiro, J.; et al. "Corrigendum to Use of poly(DL-lactide-e-caprolactone) membranes and mesenchymal stem cells from the Wharton's jelly of the umbilical cord for promoting nerve regeneration in axonotmesis: In vitro and in vivo analysis [Differentiation 84 (2012) 355-365]". Differentiation 85 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84878909587&partnerID=MN8TOARS.
    10.1016/j.diff.2013.03.001
  35. Dias, T.R.; Martins, A.D.; Reis, V.P.; Socorro, S.; Silva, B.M.; Alves, M.G.; Oliveira, P.F.. "Glucose transport and metabolism in sertoli cell: Relevance for male fertility". Current Chemical Biology 7 3 (2013): 282-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901288156&partnerID=MN8TOARS.
  36. Bernardino, R.L.; Martins, A.D.; Socorro, S.; Alves, M.G.; Oliveira, P.F.. "Effect of prediabetes on membrane bicarbonate transporters in testis and epididymis". Journal of Membrane Biology 246 12 (2013): 877-883. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888216253&partnerID=MN8TOARS.
    10.1007/s00232-013-9601-4
  37. Alves, M.G.; Neuhaus-Oliveira, A.; Moreira, P.I.; Socorro, S.; Oliveira, P.F.. "Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells". Reproductive Toxicology 38 (2013): 81-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876339594&partnerID=MN8TOARS.
    10.1016/j.reprotox.2013.03.005
  38. Laurentino, S.S.; Pinto, P.I.S.; Tomás, J.; Cavaco, J.E.; Sousa, M.; Barros, A.; Power, D.M.; Canário, A.V.M.; Socorro, S.. "Identification of androgen receptor variants in testis from humans and other vertebrates". Andrologia 45 3 (2013): 187-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876814362&partnerID=MN8TOARS.
    10.1111/j.1439-0272.2012.01333.x
  39. Rato, L.; Alves, M.G.; Dias, T.R.; Lopes, G.; Cavaco, J.E.; Socorro, S.; Oliveira, P.F.. "High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters.". Andrology 1 3 (2013): 495-504. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885600016&partnerID=MN8TOARS.
  40. Alves, M.G.; Rato, L.; Carvalho, R.A.; Moreira, P.I.; Socorro, S.; Oliveira, P.F.. "Hormonal control of Sertoli cell metabolism regulates spermatogenesis". Cellular and Molecular Life Sciences 70 5 (2013): 777-793. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873719667&partnerID=MN8TOARS.
    10.1007/s00018-012-1079-1
  41. Simões, V.L.; Alves, M.G.; Martins, A.D.; Dias, T.R.; Rato, L.; Socorro, S.; Oliveira, P.F.. "Regulation of apoptotic signaling pathways by 5a-dihydrotestosterone and 17ß-estradiol in immature rat Sertoli cells". Journal of Steroid Biochemistry and Molecular Biology 135 1 (2013): 15-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874408605&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2012.11.019
  42. Gomes, I.M.; Santos, C.R.; Socorro, S.; Maia, C.J.. "Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells". Prostate 73 6 (2013): 605-613. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875803548&partnerID=MN8TOARS.
    10.1002/pros.22601
  43. Bernardino, R.L.; Jesus, T.T.; Martins, A.D.; Sousa, M.; Barros, A.; Cavaco, J.E.; Socorro, S.; Alves, M.G.; Oliveira, P.F.. "Molecular basis of bicarbonate membrane transport in the male reproductive tract". Current Medicinal Chemistry 20 32 (2013): 4037-4049. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887961875&partnerID=MN8TOARS.
    10.2174/15672050113109990200
  44. Alves, M.G.; Martins, A.D.; Rato, L.; Moreira, P.I.; Socorro, S.; Oliveira, P.F.. "Molecular mechanisms beyond glucose transport in diabetes-related male infertility". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 5 (2013): 626-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874414576&partnerID=MN8TOARS.
    10.1016/j.bbadis.2013.01.011
  45. Correia, S.; Oliveira, P.F.; Guerreiro, P.M.; Lopes, G.; Alves, M.G.; Canário, A.V.M.; Cavaco, J.E.; Socorro, S.. "Sperm parameters and epididymis function in transgenic rats overexpressing the Ca2+-binding protein regucalcin: A hidden role for Ca2+ in sperm maturation?". Molecular Human Reproduction 19 9 (2013): 581-589. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883162067&partnerID=MN8TOARS.
    10.1093/molehr/gat030
  46. Gärtner A; Pereira T; Alves MG; Armada-da-Silva PA; Amorim I; Gomes R; Ribeiro J; et al. "Use of poly(DL-lactide-e-caprolactone) membranes and mesenchymal stem cells from the Wharton's jelly of the umbilical cord for promoting nerve regeneration in axonotmesis: in vitro and in vivo analysis.". (2012): http://europepmc.org/abstract/med/23142731.
    10.1016/j.diff.2012.10.001
  47. Oliveira, P.F.; Alves, M.G.; Rato, L.; Laurentino, S.; Silva, J.; Sá, R.; Barros, A.; et al. "Effect of insulin deprivation on metabolism and metabolism-associated gene transcript levels of in vitro cultured human Sertoli cells". Biochimica et Biophysica Acta - General Subjects 1820 2 (2012): 84-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455235851&partnerID=MN8TOARS.
    10.1016/j.bbagen.2011.11.006
  48. Vaz, C.V.; Alves, M.G.; Marques, R.; Moreira, P.I.; Oliveira, P.F.; Maia, C.J.; Socorro, S.. "Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile". International Journal of Biochemistry and Cell Biology 44 11 (2012): 2077-2084. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865554409&partnerID=MN8TOARS.
    10.1016/j.biocel.2012.08.013
  49. Rato, L.; Alves, M.G.; Socorro, S.; Carvalho, R.A.; Cavaco, J.E.; Oliveira, P.F.. "Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells cultured in vitro". Bioscience Reports 32 1 (2012): 61-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855896846&partnerID=MN8TOARS.
    10.1042/BSR20110030
  50. Rato, L.; Alves, M.G.; Socorro, S.; Duarte, A.I.; Cavaco, J.E.; Oliveira, P.F.. "Metabolic regulation is important for spermatogenesis". Nature Reviews Urology 9 6 (2012): 330-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862208844&partnerID=MN8TOARS.
    10.1038/nrurol.2012.77
  51. Alves, M.G.; Oliveira, P.F.; Socorro, S.; Moreira, P.I.. "Impact of diabetes in blood-testis and blood-brain barriers: Resemblances and differences". Current Diabetes Reviews 8 6 (2012): 401-412. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870183874&partnerID=MN8TOARS.
    10.2174/157339912803529896
  52. Alves, M.G.; Socorro, S.; Silva, J.; Barros, A.; Sousa, M.; Cavaco, J.E.; Oliveira, P.F.. "In vitro cultured human Sertoli cells secrete high amounts of acetate that is stimulated by 17ß-estradiol and suppressed by insulin deprivation". Biochimica et Biophysica Acta - Molecular Cell Research 1823 8 (2012): 1389-1394. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862625700&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2012.06.002
  53. Laurentino, S.S.; Correia, S.; Cavaco, J.E.; Oliveira, P.F.; de Sousa, M.D.; Barros, A.; Socorro, S.. "Regucalcin, a calcium-binding protein with a role in male reproduction?". Molecular Human Reproduction 18 4 (2012): 161-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858685367&partnerID=MN8TOARS.
    10.1093/molehr/gar075
  54. Pinto, P.I.S.; Teodósio, R.; Socorro, S.; Power, D.M.; Canário, A.V.M.. "Structure, tissue distribution and estrogen regulation of splice variants of the sea bream estrogen receptor a gene". Gene 503 1 (2012): 18-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861783170&partnerID=MN8TOARS.
    10.1016/j.gene.2012.04.081
  55. Laurentino, S.S.; Correia, S.; Cavaco, J.E.; Oliveira, P.F.; Rato, L.; Sousa, M.; Barros, A.; Socorro, S.. "Regucalcin is broadly expressed in male reproductive tissues and is a new androgen-target gene in mammalian testis". Reproduction 142 3 (2011): 447-456. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051992405&partnerID=MN8TOARS.
    10.1530/REP-11-0085
  56. Laurentino, S.; Gonalves, J.; Cavaco, J.E.; Oliveira, P.F.; Alves, M.G.; De Sousa, M.; Barros, A.; Socorro, S.. "Apoptosis-inhibitor Aven is downregulated in defective spermatogenesis and a novel estrogen target gene in mammalian testis". Fertility and Sterility 96 3 (2011): 745-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052262541&partnerID=MN8TOARS.
    10.1016/j.fertnstert.2011.06.009
  57. Oliveira, P.F.; Alves, M.G.; Rato, L.; Silva, J.; Sá, R.; Barros, A.; Sousa, M.; et al. "Influence of 5a-dihydrotestosterone and 17ß-estradiol on human Sertoli cells metabolism". International Journal of Andrology 34 6 PART 2 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-81455158931&partnerID=MN8TOARS.
    10.1111/j.1365-2605.2011.01205.x
  58. Gomes I; Santos CR; Socorro S; Lopes C; Maia CJ. "STEAP1 expression in prostate cancer and its regulation by androgens.". (2010): http://europepmc.org/abstract/PMC/PMC3255063.
  59. Maia CJ; Vaz CV; Peres CG; Santos CR; Socorro S. "Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?". (2010): http://europepmc.org/abstract/PMC/PMC3255008.
  60. Rato, L.; Socorro, S.; Cavaco, J.E.B.; Oliveira, P.F.. "Tubular fluid secretion in the seminiferous epithelium: Ion transporters and aquaporins in sertoli cells". Journal of Membrane Biology 236 2 (2010): 215-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650212931&partnerID=MN8TOARS.
    10.1007/s00232-010-9294-x
  61. Cavaco, J.E.B.; Laurentino, S.S.; Barros, A.; Sousa, M.; Socorro, S.. "Estrogen receptors a and ß in human testis: Both isoforms are expressed". Systems Biology in Reproductive Medicine 55 4 (2009): 137-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-72949111982&partnerID=MN8TOARS.
    10.3109/19396360902855733
  62. Pinto, P.I.S.; Estêvão, M.D.; Redruello, B.; Socorro, S.M.; Canário, A.V.M.; Power, D.M.. "Immunohistochemical detection of estrogen receptors in fish scales". General and Comparative Endocrinology 160 1 (2009): 19-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649221909&partnerID=MN8TOARS.
    10.1016/j.ygcen.2008.10.011
  63. Alves, C.H.; Gonçalves, I.; Socorro, S.; Baltazar, G.; Quintela, T.; Santos, C.R.A.. "Androgen receptor is expressed in murine choroid plexus and downregulated by 5a-Dihydrotestosterone in male and female mice". Journal of Molecular Neuroscience 38 1 (2009): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949213641&partnerID=MN8TOARS.
    10.1007/s12031-008-9157-4
  64. Maia, C.; Santos, C.; Schmitt, F.; Socorro, S.. "Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones". Journal of Cellular Biochemistry 107 4 (2009): 667-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650087642&partnerID=MN8TOARS.
    10.1002/jcb.22158
  65. Maia, C.J.B.; Santos, C.R.; Schmitt, F.; Socorro, S.. "Regucalcin is expressed in rat mammary gland and prostate and down-regulated by 17ß-estradiol". Molecular and Cellular Biochemistry 311 1-2 (2008): 81-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-41349096904&partnerID=MN8TOARS.
    10.1007/s11010-007-9697-x
  66. Maia, C.J.B.; Socorro, S.; Schmitt, F.; Santos, C.R.A.. "STEAP1 is over-expressed in breast cancer and down-regulated by 17ß-estradiol in MCF-7 cells and in the rat mammary gland". Endocrine 34 1-3 (2008): 108-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-65449116921&partnerID=MN8TOARS.
    10.1007/s12020-008-9113-7
  67. Maia, C.J.B.; Socorro, S.; Schmitt, F.; Santos, C.R.A.. "Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: Effects of 17ß-estradiol on the regulation of OAS1g in both tissues". Molecular and Cellular Biochemistry 314 1-2 (2008): 113-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449097052&partnerID=MN8TOARS.
    10.1007/s11010-008-9771-z
  68. Gonçalves, I.; Alves, C.H.; Quintela, T.; Baltazar, G.; Socorro, S.; Saraiva, M.J.; Abreu, R.; Santos, C.R.A.. "Transthyretin is up-regulated by sex hormones in mice liver". Molecular and Cellular Biochemistry 317 1-2 (2008): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149110036&partnerID=MN8TOARS.
    10.1007/s11010-008-9841-2
  69. Socorro, S.; Martins, R.S.; Deloffre, L.; Mylonas, C.C.; Canario, A.V.M.. "A cDNA for European sea bass (Dicentrachus labrax) 11ß-hydroxylase: Gene expression during the thermosensitive period and gonadogenesis". General and Comparative Endocrinology 150 1 (2007): 164-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845192413&partnerID=MN8TOARS.
    10.1016/j.ygcen.2006.07.018
  70. Moutou, K.A.; Socorro, S.; Power, D.M.; Mamuris, Z.; Canario, A.V.M.. "Molecular cloning and sequence of gilthead sea bream (Sparus aurata) a-skeletal actin: Tissue and developmental expression". Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology 130 1 (2001): 13-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034935045&partnerID=MN8TOARS.
    10.1016/S1096-4959(01)00381-5
  71. Socorro, S.; Power, D.M.; Olsson, P.-E.; Canario, A.V.M.. "Two estrogen receptors expressed in the teleost fish, sparus aurata: cDNA cloning, characterization and tissue distribution". Journal of Endocrinology 166 2 (2000): 293-306. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033838723&partnerID=MN8TOARS.
Capítulo de livro
  1. Sara Correia; Pillai, H; Silva. AMS; Santos, VM; Socorro, Sílvia. "The horizons of regucalcin in male reproduction.". In Regucalcin: Metabolic Regulation and Disease. Nova Science Publishers, Inc,, 2019.
    Publicado
  2. Figueira, Marília I.; Cardoso, Henrique J.; Socorro, Sílvia. "The Role of GPER Signaling in Carcinogenesis: A Focus on Prostate Cancer". In Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs, 59-117. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-71553-7_5
  3. Cavaco, J.E.; Laurentino, S.; Correia, S.; Pinto, P.; Socorro, S.. "Naturally occurring androgen receptor splice variants: Impact on androgen signaling pathways". 2014.
  4. Pinto, P.; Estêvão, M.D.; Socorro, S.. "Androgen receptors in non-mammalian vertebrates: Structure and function". In Androgen Receptor: Structural Biology, Genetics and Molecular Defects. 2014.
  5. Vaz, C.V.; Alves, M.G.; Marques, R.; Oliveira, P.F.; Maia, C.J.; Socorro, S.. "Glucose uptake and androgen responsiveness of prostate cancer cells". 2013.
  6. Dias, T.R.; Alves, M.G.; Neuhaus-Oliveira, A.; Socorro, S.; Silva, B.M.; Oliveira, P.F.. "Implications of diabetes on sperm glucose uptake and metabolism". 2013.
  7. Gomes, IM; Vaz, C.V.; Rodrigues, D; Rocha, SM; Socorro, Sílvia; Santos, CR; Maia CJ. "Estrogens and prostate cancer". In Estradiol: synthesis, Health Effects and Drug Interactions. New York, Estados Unidos: Nova Science Publishers, Inc, 2013.
    Publicado
  8. Rato, L.; Alves, M.G.; Socorro, S.; Cavaco, J.E.; Oliveira, P.F.. "Blood testis barrier: How does the seminiferous epithelium feeds the developing germ cells?". 2012.
Edição de livro
  1. Socorro, S.. Androgen receptor: Structural biology, genetics and molecular defects. 2014.
    Publicado
Livro
  1. Socorro, S.. Preface. 2014.
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018 - Atual Unrevealing the effect of STEAP1 knokdown in prostate cancer cells; from protein expression profile to clinical applications
Coorientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2016 - Atual TRIB1/3 modulation of androgen actions in prostate cancer
Orientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2015 - Atual Estrogens and the G protein-coupled estrogen receptor in prostate cancer: angels or demons?
Orientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2015 - 2019 Prostate cancer cells metabolism on the interplay of androgenic regulation and metabolic environment
Orientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2018 - 2018 Fatores psicossociais relacionados com a infertilidade feminina em Cabinda (Angola)
Coorientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2012 - 2016 Genética molecular do hipogonadismo hipogonadotrófico idiopático
Coorientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2012 - 2016 Biological evidence of the protective role of regucalcin in beast cancer
Orientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2011 - 2015 Androgens and calcium-binding protein regucalcin in the control of prostate cells metabolism and survival: implicatons in carcinogenesis
Orientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2011 - 2014 Estrogens and Regucalcin in Testicular Apoptosis and Sperm Function: a Mather of Life and Death
Orientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2008 - 2011 Sexual Steroid Regulation of Spermatogensis: New Actors Enter the Stage
Orientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2005 - 2008 Novel genes differentially expressed in breast and prostate cancer: effects of sex steroid hormones
Orientador
 Biomedicina (Doutoramento)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Distinções

Prémio

2021 Prémio Carreira Alumni da Universidade do Algarve
Universidade do Algarve, Portugal