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Dr. Catarina M. Seabra obtained a PhD in 2017 from the GABBA program at the University of Porto, and built a strong background in human neurogenetics. She acquired international experience during her PhD as she trained at renowned institutions in the USA, such as the Center for Genomic Medicine, Harvard Medical School and Broad Institute of MIT and Harvard. Dr. Seabra's work has advanced knowledge in the autism research field as she used cutting-edge technology to identify disease-associated pathways which may be suitable targets for treatment. Her publication record includes the contribution to 12 journal articles with 592 citations (Google Scholar h-index=8), including in journals such as Nature Genetics and Nature Neuroscience and Molecular Autism. As an educator, Dr. Seabra was invited as Assistant Professor at the University of Coimbra in 2020 to teach experimental classes to Biology degree students. Additionally, Dr. Seabra is the main supervisor of MSc and PhD students and has also taught advanced PhD-level courses. Dr. Seabra has a vast experience in project management, leadership and public engagement, as evidenced by an active role in scientific and academic committees. She has organized scientific events and has created opportunities by co-founding internship programs, such as PAPSummer and Maria de Sousa Research Program, through successful fundraising (30,000 Euros). In 2018, she attracted European funds through an H2020 MSCA Individual Fellowship of 148,000 Euros and has proven her independence through project management and establishment of international collaborations. Dr. Seabra was acknowledged for her scientific excellence with two Merit Awards. In 2021, Dr. Seabra was awarded a CEEC FCT contract to pursue research towards the development of 3D brain organoids to explore the impact of genetic alterations on brain development and wiring, by adopting a multidisciplinary approach, at a leading institute for neuroscience research in Portugal, CNC (CIBB). In the future, she aims to work in a research-intensive tenure-track university position and lead high quality research in an independent research group, while contributing to science outreach.
Identificação

Identificação pessoal

Nome completo
Catarina Morais Seabra

Identificadores de autor

Ciência ID
AB15-E7E3-74D6
ORCID iD
0000-0003-2862-1979

Endereços de correio eletrónico

  • cseabra@cnc.uc.pt (Profissional)

Websites

  • https://www.linkedin.com/in/cmseabra/ (Profissional)
Formação
Grau Classificação
2020/01/17 - 2020/10/31
Concluído
micro-MBA (Outros)
Especialização em Project Management and Leadership
UNAVE - Association for Professional Training and Research at the University of Aveiro, Portugal
9 out of 10 (Excellent)
2013/01/01 - 2017/10/03
Concluído
Graduate Program in Areas of Basic and Applied Biology (GABBA) (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Center for Genomic Medicine, Harvard Medical School, Estados Unidos
"Discovering Pathways Underlying Autism Spectrum Disorder Upon Loss-of-Function of Chromatin-Related Genes" (TESE/DISSERTAÇÃO)
Unanimously Approved
2010 - 2012
Concluído
Molecular Biomedicine (Mestrado)
Universidade de Aveiro, Portugal
"Rare Structural Variants in Spermatogenic Impairment" (TESE/DISSERTAÇÃO)
18 out of 20
2007 - 2010
Concluído
Biomedical Sciences (Licenciatura)
Universidade de Aveiro, Portugal
15 out of 20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2021/08/01 - Atual Investigador Contratado (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/05/07 - 2020/05 Investigador Auxiliar (carreira) (Investigação) CNC.IBILI, Portugal
2017/11/06 - 2018/05/04 Pós-doutorado (Investigação) CNC.IBILI, Portugal
2016/06/01 - 2017/10/01 Investigador visitante (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/01/01 - 2016/06/01 Investigador visitante (Investigação) Center for Genomic Medicine, Harvard Medical School, Estados Unidos
2011/09/01 - 2012/12/29 Estagiário de Investigação (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2020/09/01 - 2021/02/06 Professor Auxiliar Convidado (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2019/01 - Atual Scientific Career Consultant and Business Developer Chaperone, Portugal
Chaperone, Portugal
2020/06/01 - 2021/05/31 Project and Community Manager Open Science Hub - Portugal, Portugal
Open Science Hub - Portugal, Portugal
Projetos

Bolsa

Designação Financiadores
2021 - Atual Exploring the Immunogenetics of FTD using advanced human brain organoids
EN119
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Takeda Pharmaceuticals International AG
2021 - Atual Disease modelling of frontotemporal dementia in human brain organoids
PTDC/MEC-NEU/4814/2020
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2019 - Atual Syn2Psy - Synaptic Dysfunction in Neuropsychiatric Disorders
813986
Orientador
CNC.IBILI, Portugal
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2018 - 2020/05/06 ProTeAN - Production and Testing of Human Neurons and Brain Orgnoids
799164
Investigador
CNC.IBILI, Portugal
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2017 - 2018/04 Social Hierarchy and Early Life Stress Adversity: Optogenetic Modulation of Prefrontal Cortical Circuits and Neuroepigenetic Regulation
PTDC/NEU-SCC/3247/2014
Bolseiro de Integração na Investigação
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Sequeira, Diana B.; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo J.; Ramos, Carlos; Figueiredo, Maria H.; Santos, Ana C.; et al. "Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials". Clinical Oral Investigations (2021): http://dx.doi.org/10.1007/s00784-021-03840-9.
    Publicado • 10.1007/s00784-021-03840-9
  2. Seabra, Catarina M.; Aneichyk, Tatsiana; Erdin, Serkan; Tai, Derek J. C.; De Esch, Celine E. F.; Razaz, Parisa; An, Yu; et al. "Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons". Molecular Autism 11 1 (2020): http://dx.doi.org/10.1186/s13229-020-00354-1.
    Acesso aberto • Publicado • 10.1186/s13229-020-00354-1
  3. Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Edfawy, Mohamed; et al. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". (2020):
    Em revisão
  4. Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João. "Effects of a New Bioceramic Material on Human Apical Papilla Cells". Journal of Functional Biomaterials 9 4 (2018): 74. http://dx.doi.org/10.3390/jfb9040074.
    Publicado • 10.3390/jfb9040074
  5. Collins RL; Brand H; Redin CE; Hanscom C; Antolik C; Stone MR; Glessner JT; et al. "Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome.". Genome Biology (2017): http://europepmc.org/abstract/med/28260531.
    Publicado • 10.1186/s13059-017-1158-6
  6. Shaw ND; Brand H; Kupchinsky ZA; Bengani H; Plummer L; Jones TI; Erdin S; et al. "SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.". Nature Genetics (2017): http://europepmc.org/abstract/med/28067909.
    Publicado • 10.1038/ng.3743
  7. Redin C; Brand H; Collins RL; Kammin T; Mitchell E; Hodge JC; Hanscom C; et al. "The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies.". Nature Genetics (2017): http://europepmc.org/abstract/med/27841880.
    Publicado • 10.1038/ng.3720
  8. Seabra, C.M.; Szoko, N.; Erdin, S.; Ragavendran, A.; Stortchevoi, A.; Maciel, P.; Lundberg, K.; et al. "A novel microduplication of ARID1B: Clinical, genetic, and proteomic findings". American Journal of Medical Genetics, Part A 173 9 (2017): 2478-2484. http://www.scopus.com/inward/record.url?eid=2-s2.0-85023177636&partnerID=MN8TOARS.
    Publicado • 10.1002/ajmg.a.38327
  9. Tai DJ; Ragavendran A; Manavalan P; Stortchevoi A; Seabra CM; Erdin S; Collins RL; et al. "Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR.". Nature Neuroscience (2016): http://europepmc.org/abstract/med/26829649.
    Publicado • 10.1038/nn.4235
  10. Seabra CM; Quental S; Lima AC; Carvalho F; Gonçalves J; Fernandes S; Pereira I; et al. "The mutational spectrum of WT1 in male infertility.". The Journal of Urology (2015): http://europepmc.org/abstract/med/25451826.
    Publicado • 10.1016/j.juro.2014.11.004
  11. Seabra CM; Quental S; Neto AP; Carvalho F; Gonçalves J; Oliveira JP; Fernandes S; et al. "A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia.". Reproductive BioMedicine Online (2014): http://europepmc.org/abstract/med/24912414.
    Publicado • 10.1016/j.rbmo.2014.04.017
  12. Lopes AM; Aston KI; Thompson E; Carvalho F; Gonçalves J; Huang N; Matthiesen R; et al. "Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1.". PLoS Genetics (2013): http://europepmc.org/abstract/med/23555275.
    Publicado • 10.1371/journal.pgen.1003349
Poster em conferência
  1. Silva, Ana Manuela; Seabra, Catarina M.; Oliveira, Ana Rafaela; Laranjo, Mariana; Duque, Frederico; Café, Cátia; Peça, João; Oliveira, Guiomar. "Autism Spectrum Disorder seen through brain organoids - a Portuguese cohort characterization.". Trabalho apresentado em In4Med IX, 2020.
  2. Oliveira, Ana R.; Seabra, Catarina M.; Guedes, Joana R.; Ferreira, L.; Peça, João. "Mini-brains on a dish: Characterization of autism susceptibility genes using iPSCs and CRISPR/Cas9 gene engineering.". Trabalho apresentado em 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2019.
  3. Seabra, Catarina M.; Oliveira, Ana Rafaela; Guedes, Joana R.; Sequeira, Diana B.; Palma, Paulo J.; Santos, João M.; Duque, Frederico; et al. "Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neurosciences (SPN), 2019.
  4. Seabra, Catarina M.; Sequeira, Diana; Palma, Paulo; Oliveira, Guiomar; Duque, Frederico; Santos, João; Feng, Guoping; Cardoso, Ana; Peça, João. "Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders". Trabalho apresentado em FENS-SfN Summer School 2018, 2018.
  5. Seabra, Catarina M.; Manavalan P; Tai DJ; Talkowski ME; Gusella JF. "Comparison of CRISPR-based methods for modeling loss-of-function in iPS cells". Trabalho apresentado em European Society for Human Genetics Meeting, 2016.
  6. Seabra, Catarina M.; Manavalan P; Tai DJ; De Esch C; Ragavendran A; Erdin S; Maciel, P.; Talkowski ME; Gusella JF. "Modeling the functional genomic impact of mutations in chromatin regulators on neurodevelopment". Trabalho apresentado em MGH Scientific Advisory Committee Meeting, 2016.
Resumo em conferência
  1. Seabra, Catarina M.; Oliveira, Ana Rafaela; Guedes, Joana Ribeiro; Cardoso, Ana Luísa; Sequeira, Diana; Palma, Paulo J.; Santos, João Miguel; et al. "The neurogenetics of neurodevelopmental disorders - Hints from brain organoids". Trabalho apresentado em Annual Meeting of the Portuguese Society for Human Genetics, 2020.
    Publicado • doi: 10.1097/MD.0000000000019291
Tese / Dissertação
  1. Catarina Morais Seabra. "Discovering pathways underlying autism spectrum disorder upon loss-of-function of chromatin-related genes". Doutoramento, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2017. http://hdl.handle.net/10216/107262.
  2. Seabra, Catarina M.; Seabra, Catarina Morais. "Rare structural variants in severe spermatogenic impairment". Mestrado, Universidade do Porto Instituto de Patologia e Imunologia Molecular, 2012. http://hdl.handle.net/10773/9537.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/11/23 Brain Organoids to model Autism Spectrum Disorder - Challenges and Advances Organoids without Borders
i3S - Instituto de Investigação e Inovação em Saúde da Universidade do Porto (Porto, Portugal)
2020/06/08 Brain Organoids: Advanced Models to Study Autism Spectrum Disorder StemCell Tech Virtual Seminar
StemCell Technologies
2020/04/11 Science and Research in Autism Online Conferences
Association PARA (Portugal)
2019/04 Using Mini-Brains to Study Autism XII National Meeting for Biochemistry Students
(Aveiro, Portugal)
2019/03 From Biomedical Sciences to the Study of Autism X National Conference on Biomedical Sciences
(Aveiro, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021/09/01 - Atual The role of primary cilia in Autism Spectrum Disorder
Orientador
Universidade de Aveiro, Portugal
2019/01 - Atual Using brain organoids to model autism spectrum disorder - environmental and genetic perspectives
Coorientador de Giuseppe Cammarata
Universidade de Coimbra, Portugal
2019/01 - 2020/06 Application of Brain Organoids to study Autism Spectrum Disorder in a Portuguese Cohort
Coorientador de Ana Manuela Silva
Universidade de Coimbra, Portugal
2019/02 - 2019/07 Use of Dental Stem Cells to Study Autism
Orientador de Sara Cruz
Biology (Licenciatura/Bacharelato)
Universidade de Coimbra, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2021/03/10 - 2021/03/31 Brain Awareness Week Symposia: Brain Gain - Discovering Neurosciences (2021/03/10 - 2021/03/31)
Simpósio
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Sociedade Portuguesa de Neurociências, Portugal
2020/03/31 - 2020/03/31 Mini-Symposium: Brain Organoids and Biobanking (2020/03/31 - 2020/03/31)
Simpósio (Membro da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/01/01 - 2019/12 Maria de Sousa Summer Research Program (2017/01/01)
Outro (Coorganizador)
All Time GABBA (ATG), Portugal
2019/09/01 - 2019/09/01 Functional Neurosciences Workshop (2019/11/01 - 2019/11/01)
Oficina (workshop) (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2018 - Atual European Researchers Night
Festival
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/01/26 - 2020/01/31 Stanford Human Brain Organoids Workshop
Oficina (workshop)
Stanford University Center for Interdisciplinary Brain Sciences Research, Estados Unidos
2019/11 - 2019/11 Bioethics Debate: Designer Babies: How far can we go to create a perfect human being?
Conferência
Universidade de Aveiro, Portugal
2018/06 - 2018/06 FENS SfN Summer School - Neural Stem Cells, Brain Organoids and Brain Repair
Oficina (workshop)
Federation of European Neuroscience Societies, Bélgica

Society for Neuroscience, Estados Unidos
2018 - 2018 PubhD Coimbra
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2019/10/08 Establishment and Characterization of Human Pluripotent Stem Cells Derived Brain Organoids
Arguente principal
João Brás (Mestrado)
Universidade de Coimbra, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/09/01 - 2021/02/06 Cellular Physiology Cellular Physiology (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/11/01 - 2019/11/01 Stem cells and 3D cellular models (Licenciatura) Universidade de Coimbra, Portugal
2019/09/01 - 2019/09/01 Culture of cells, tissues and organs (Doutoramento) Universidade de Coimbra, Portugal
2019/03/01 - 2019/03/01 Advanced models in neuropsychiatry research (Doutoramento) Universidade de Coimbra, Portugal
2019 - 2019 Ciência Viva School - Scientific Activities for 4th grade students (Ensino básico 1º ciclo) CNC.IBILI, Portugal

Ciência Viva, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2020/01/02 - Atual Admirable New World (National TV Channel SIC) Brain Organoids as Promising Models for Neurological Disorders
2018/05/28 - 2018/05/28 Saúde em Dia (Saúde + Channel) Neurodevelopmental disorders
2018/05/14 - 2018/05/14 Há Ciência (Antena 2 Radio Station) The jobs and the days of scientists
2018/05/01 - 2018/05/01 Mentes que Brilham (Porto Canal Channel) Program on science and research that gives voice to the most varied topics of the present time.

Membro de associação

Nome da associação Tipo de participação
2019 - Atual Marie Curie Alumni Association Member

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2019/04/01 - Atual All Time GABBA (ATG) - Treasurer
Membro
All Time GABBA (ATG), Portugal

Tutoria

Tópico Nome do aluno
2019/08/01 - 2019/12/20 Erasmus Internship - University of Cordoba Pilar Rodríguez
2019/07 - 2019/07 Mentorship of an Undergraduate Student - Maria de Sousa Summer Research Program Iria Freitas
2019/07 - 2019/07 Mentorship of BSc Student - Biomedical Sciences, University of Aveiro Mariana Martins
2019/07 - 2019/07 Mentorship of BSc Student - Biology, University of Coimbra João Videira
Distinções

Prémio

2020 Best Poster in Translational Research - In4Med IX Medical Congress
In4Med, Portugal
2019 Honorable Mention in Basic Research - SPGH 23rd Annual Meeting
Portuguese Society for Human Genetics (SPGH), Portugal
2018 Municipal Merit Award for Scientific Excellence
Município de Gouveia, Portugal
2018 Merit Award for Scientific Excellence
Junta de Freguesia de Vila Nova de Tazem, Portugal
2016 Conference Fellowship - ESHG 12th Meeting
European Society for Human Genetics, Áustria

Título

2021 Junior Researcher (CEEC 3rd Edition)
Fundação para a Ciência e a Tecnologia, Portugal
2018 Marie Sklodowska-Curie Fellow (Reintegration Panel)
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Bélgica
2012 Doctoral Fellow - GABBA PhD Program
Fundação para a Ciência e a Tecnologia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal