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Carlos Palmeira, is Full Professor in the Department of Life Sciences, University of Coimbra, Portugal and PI at Center for Neurosciences and Cell Biology, from the same University. His research interests are focused on the pathophysiological mechanisms of mitochondrial dysfunction and human health, with particular expertise in the study of the role of mitochondrial dysfunction in the pathogenesis of hepatic diseases and ischemia/reperfusion. He is a member of several national/international societies, and serves as Associate Editor in the journals Toxicology and Applied Pharmacology and Toxicology Mechanisms and Methods, being member of the Editorial Board in several other journals. He is author/co-author of more than 150 papers. He received his Ph.D in Biochemistry at the University of Coimbra, Portugal and postdoctoral training in biochemical toxicology at the University of Minnesota, Duluth, USA.
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Identificação

Identificação pessoal

Nome completo
Carlos Palmeira

Nomes de citação

  • Palmeira, Carlos
  • Palmeira, Carlos M.

Identificadores de autor

Ciência ID
9C17-78E6-DA25
ORCID iD
0000-0002-2639-7697

Telefones

Telefone
  • (+351) 239240700 (Profissional)

Moradas

  • DEPARTAMENTO DE CIÊNCIAS DA VIDA, Universidade de Coimbra, Colégio de S. Bento, Calçada Martim de Freitas, 3000-456, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Medicina Básica - Toxicologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2010/02
Concluído
 Biociências (Título de Agregado)
Especialização em Biologia Celular e Molecular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1995/01/13
Concluído
 Bioquímica (Doutoramento)
Especialização em Toxicologia Bioquímica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Alterações Metabólicas em Células Hepáticas de Rato Induzidas por Herbicidas de Uso Generalizado " (TESE/DISSERTAÇÃO)
1989/09
Concluído
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1997 - Atual Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1995/02/01 - 1997/03/31 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Minnesota, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/09/03 - Atual Professor Catedrático (Docente Universitário) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2006/03/01 - 2012/09/03 Professor Associado (Docente Universitário) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
1997/04/01 - 2006/03/01 Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2010/11 - 2012/11 Diretor do Departamento de Ciências da Vida Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008 - 2009 Diretor do Departamento de Zoologia Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002 - 2004 Diretor do Departamento de Zoologia Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2000 - 2002 Diretor do Departamento de Zoologia Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - 2022 FRUITIFY - Use of blueberry juice as a nutraceutical strategy targeting gut dysbiosis to prevent the progression from prediabetes to diabetes
PTDC/SAU-NUT/31712/2017 | POCI-01-0145-FEDER-031712
 Fundação para a Ciência e a Tecnologia
2011/09 - 2012/08 ABILITY OF A MITOCHONDRIAL IMPROVER, BERBERINE, TO ATTENUATE PARKINSON´S DISEASE
RRIA 2011
 Michael J Fox Foundation for Parkinson's Research

Projeto

Designação Financiadores
2026 - 2030 Comparative effects of viable or inactivated Bacillus coagulans administration in the prevention of diet-induced fatty liver. Implication of extracellular vesicles as effector components
PID2024-159734OA-I00
Investigador
UNIVERSIDAD DEL PAIS VASCO EUSKAL HERRIKO UNIBERTSITATEA, Espanha
Em curso
2018 - 2022 FRUITIFY - Use of blueberry juice as a nutraceutical strategy targeting gut dysbiosis to prevent the progression from prediabetes to diabetes
PTDC/SAU-NUT/31712/2017 | POCI-01-0145-FEDER-031712
Investigador
Universidade de Coimbra Faculdade de Medicina, Portugal
Concluído
2018/06/01 - 2021/05/31 Use of blueberry juice as a nutraceutical strategy aimed at intestinal dysbiosis to prevent the evolution of pre-diabetes to diabetes
PTDC/SAU-NUT/31712/2017
Investigador
Universidade de Coimbra, Portugal

Universidade Católica Portuguesa, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2016/03 - 2019/12 A INTERAÇÃO ENTRE cAMP E SIRTUÍNAS COMO UM MECANISMO DE CONTROLO MITOCONDRIAL E METABÓLICO
PTDC /BIM-MEC / 6911 / 2014
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Secretaria de Estado de Ciência Tecnologia e Ensino Superior
Concluído
2016 - 2019 EXERCITANDO O FUTURO: Exercício voluntário durante diabetes gestacional com uma estratégia para melhorar a função mitocondrial na descendência.
PTDC /DTP-DES / 1082 / 2014
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2013/03 - 2014/02 Chronic effects of silver nanoparticles (AgNPs) on rat liver, kidney and heart mitochondrial function
FA8655-13-1-3036
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 EOARD
Concluído
2010 - 2013 ALTERAÇÕES NAS VIAS FISIOLÓGICAS E MECANISMOS MOLECULARES REGULADORES DA HOMEOSTASE ENERGÉTICA NA OBESIDADE E SÍNDROME METABÓLICO: IDENTIFICAÇÃO DE NOVAS ESTRATÉGIAS E ALVOS TERAPÊUTICOS
PTDC /SAU-NEU / 102612 / 2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2011/09 - 2012/08 ABILITY OF A MITOCHONDRIAL IMPROVER, BERBERINE, TO ATTENUATE PARKINSON´S DISEASE
RRIA 2011
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Michael J Fox Foundation for Parkinson's Research
Concluído
2010/03 - 2012/08 BENEFÍCIOS DO CONTROLO METABÓLICO PRECOCE: PREVENÇÃO DA FORMAÇÃO DE MEMÓRIA HIPERGLICÉMICA ATRAVÉS DA ESTIMULAÇÃO DA BIOENERGÉTICA.
PTDC /QUI-BIQ / 103514 / 2008
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluído
2010/03 - 2012/08 BENEFÍCIOS DO CONTROLO METABÓLICO PRECOCE: PREVENÇÃO DA FORMAÇÃO DE MEMÓRIA HIPERGLICÉMICA ATRAVÉS DA ESTIMULAÇÃO DA BIOENERGÉTICA.
PTDC /QUI-BIQ / 103514 / 2008
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
2007/09 - 2010/12 ALTERAÇÕES NAS VIAS FISIOLÓGICAS E MECANISMOS MOLECULARES REGULADORES DA HOMEOSTASE ENERGÉTICA NA OBESIDADE E SÍNDROME METABÓLICO: IDENTIFICAÇÃO DE NOVAS ESTRATÉGIAS E ALVOS TERAPÊUTICOS.
PTDC /SAU-OSM / 72443 / 2006
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluído
2007/09 - 2010/12 ALTERAÇÕES NAS VIAS FISIOLÓGICAS E MECANISMOS MOLECULARES REGULADORES DA HOMEOSTASE ENERGÉTICA NA OBESIDADE E SÍNDROME METABÓLICO: IDENTIFICAÇÃO DE NOVAS ESTRATÉGIAS E ALVOS TERAPÊUTICOS.
PTDC /SAU-OSM / 72443 / 2006
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
2008/01 - 2010/01 MODULAÇÃO DAS VIAS METABÓLICAS ENVOLVIDAS NO STRESS OXIDATIVO MITOCONDRIAL EM CONDIÇÕES DE HIPERGLICÉMIA: SUA RELEVÂNCIA NA PREVENÇÃO DA DIABETES
PTDC /QUI / 72826 / 2006
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluído
2008/01 - 2010/01 MODULAÇÃO DAS VIAS METABÓLICAS ENVOLVIDAS NO STRESS OXIDATIVO MITOCONDRIAL EM CONDIÇÕES DE HIPERGLICÉMIA: SUA RELEVÂNCIA NA PREVENÇÃO DA DIABETES
PTDC /QUI / 72826 / 2006
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
2007/06 - 2008/07 IN VITRO ASSESSMENT OF SILVER NANOPARTICLES TOXICITY IN HEPATIC MITOCHONDRIAL FUNCTION
FA8655-07-1-3047
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 EOARD
Concluído
2002/06 - 2005/07 COLESTASE E ESTEATOSE HEPÁTICA: TERAPIA COM ÁCIDOS BILIARES. MECANISMOS CELULARES COM RELEVÂNCIA NA FUNÇÃO MITOCONDRIAL.
POCTI /CBO / 42486 / 2001
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluído
2002/06 - 2005/07 COLESTASE E ESTEATOSE HEPÁTICA: TERAPIA COM ÁCIDOS BILIARES. MECANISMOS CELULARES COM RELEVÂNCIA NA FUNÇÃO MITOCONDRIAL.
POCTI /CBO / 42486 / 2001
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
2004/05 - 2004/11 13C NMR ISOTOPOMER ANALYSIS OF INTERMEDIARY METABOLISM IN A ADRIAMYCIN HEART FAILURE MODEL
1774-602-6050-7901
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 National Heart Lung and Blood Institute
Concluído
2004/05 - 2004/11 13C NMR ISOTOPOMER ANALYSIS OF INTERMEDIARY METABOLISM IN A ADRIAMYCIN HEART FAILURE MODEL
1774-602-6050-7901
 National Heart Lung and Blood Institute
2001 - 2002 FUNÇÃO MITOCONDRIAL NO CÉREBRO E CORAÇÃO DE RATOS MODELO DE DIABETES MELLITUS NÃO DEPENDENTE DE INSULINA (GOTO-KAKIZAKI)
SAPIENS 43642 / 99
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
1998 - 2000 ISQUEMIA MIOCÁRDICA: ACÇÃO DE FÁRMACOS. IMPORTÂNCIA DA FUNÇÃO MITOCONDRIAL
PRAXIS / PSAU / P / SAU / /6/96
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
1997 - 2000 ISQUEMIA E DIABETES: ESTUDO COMPARATIVO DAS ALTERAÇÕES METABÓLICAS EM RATOS GK (UM MODELO GENÉTICO DE DIABETES NÃO DEPENDENTE DE INSULINA E EM RATOS WISTAR (MODELO)
PRAXIS/PSAU/P/SAU/1 /96
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
1996 - 2000 RASTREIO EXPERIMENTAL DA BIOTOXICIDADE: TECNOLOGIAS IN VITRO ALTERNATIVAS AOS TESTES ANIMAIS.
PRAXIS /2 / 2.2/BIO / 1156 / 95
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
1992 - 1995 TOXICOLOGIA APLICADA DE PESTICIDAS: ALTERAÇÕES FUNCIONAIS DE HEPATÓCITOS E SEUS MITOCÔNDRIOS
PBIC /C / BIO / 1159 / 92
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
Produções

Publicações

Artigo em conferência
  1. Ferreira, Fernanda M.; Peixoto, Francisco P.; Pereira, Olívia R.; Dinis, Lia Tânia; Domingues, M.R.M.; Palmeira, Carlos M.; Cardoso, Susana M.. "Toxicological evaluation and polyphenols characterization of pterospartum tridentatum leaf extracts". 2015.
  2. Ferreira, Fernanda M.; Peixoto, Francisco P.; Pereira, Olívia R.; Dinis, Lia Tânia; Domingues, M.R.M.; Crespí, António; Palmeira, Carlos M.; Cardoso, Susana M.. "Effect of pterospartum tridentatum enriched phenolic extract in mitochondrial bioenergetic functions". 2013.
  3. Rossato, Luciana Grazziotin; Costa, Vera M; Dallegrave, Eliane; Bastos, Maria De Lourdes; Dinis-Oliveira, Ricardo Jorge; Duarte, José A.; Palmeira, Carlos; Remião, Fernando. "Mitoxantrone: A comparative study of early and late toxic effects in rats". Trabalho apresentado em 2012 EUROTOX 48th Congress of the European Societies of Toxicology, Stockholm, 2012.
    Publicado
  4. Rossato, Luciana G.; Costa, Vera M; Firmo, Eduarda; Bastos, Maria Bastos; Palmeira, Carlos; Remião, Fernando. "Therapeutic concentrations of mitoxantrone elicit cytotoxic effects on H9c2 cells". Trabalho apresentado em EUROTOX 2011 - 47th Congress of the European Societies of Toxicology, Paris, 2011.
    Publicado
Artigo em revista
  1. José S. Morgado; Ivo F. Machado; Anabela P. Rolo; Carlos M. Palmeira. "Restoring Mitochondrial Homeostasis: Therapeutic Strategies for Metabolic Dysfunction-Associated Fatty Liver Disease". International Journal of Molecular Sciences (2026): https://doi.org/10.3390/ijms27062599.
    10.3390/ijms27062599
  2. Ghiraldelli Miranda, Raul; Machado, Ivo F.; Rolo, Anabela Pinto; Dorta, Daniel Junqueira; Palmeira, Carlos M.. "Mitochondria under fire: toxicological mechanisms of brominated flame retardants". Toxicology Mechanisms and Methods 36 1 (2025): 65-92. https://doi.org/10.1080/15376516.2025.2568145.
    10.1080/15376516.2025.2568145
  3. Heberth dos Santos Silva; Camila Ortiz; Camila Miranda; Paulo Veiga Bizerra; Carlos Palmeira; Fábio Mingatto. "Ametryn and Clomazone Disrupt Mitochondrial Bioenergetics in Rat Liver: Evidence for Inhibition of Complexes I and II and ATP Synthase". Toxics (2025): https://doi.org/10.3390/toxics13090784.
    10.3390/toxics13090784
  4. Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P.. "Sestrin2 is a central regulator of mitochondrial stress responses in disease and aging". Ageing Research Reviews 109 (2025): 102762. https://doi.org/10.1016/j.arr.2025.102762.
    10.1016/j.arr.2025.102762
  5. Ghiraldelli Miranda, Raul; Machado, Ivo F.; Rolo, Anabela Pinto; Dorta, Daniel Junqueira; Palmeira, Carlos Manuel Marques. "HepG2 spheroids cultured in alginate microcapsules as a model for exploring mitochondrial and glycolytic metabolism using the Seahorse XFe24 Analyzer". Toxicology Mechanisms and Methods 35 4 (2025): 413-421. https://doi.org/10.1080/15376516.2024.2447740.
    10.1080/15376516.2024.2447740
  6. Tiago S. Fonseca; Rui Miguel Martins; Anabela P. Rolo; Carlos M. Palmeira. "SNHG1: Redefining the Landscape of Hepatocellular Carcinoma through Long Noncoding RNAs". Biomedicines (2024): https://doi.org/10.3390/biomedicines12081696.
    10.3390/biomedicines12081696
  7. Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T.; Amorim, João A.; Bonkowski, Michael S.; Apostolides, John K.; Salfati, Elias L.; et al. "Loss of epigenetic information as a cause of mammalian aging". Cell 187 5 (2024): 1312-1313. http://dx.doi.org/10.1016/j.cell.2024.01.049.
    10.1016/j.cell.2024.01.049
  8. Panagiota-Efstathia Nikolaou; George Lambrinidis; Maria Georgiou; Dimitrios Karagiannis; Panagiotis Efentakis; Pavlos Bessis-Lazarou; Konstantina Founta; et al. "Hydrolytic Activity of Mitochondrial F1FO-ATP Synthase as a Target for Myocardial Ischemia–Reperfusion Injury: Discovery and In Vitro and In Vivo Evaluation of Novel Inhibitors". Journal of Medicinal Chemistry (2023): https://doi.org/10.1021/acs.jmedchem.3c01048.
    10.1021/acs.jmedchem.3c01048
  9. Ivo F. Machado; Raul G. Miranda; Daniel J. Dorta; Anabela P. Rolo; Carlos M. Palmeira. "Targeting Oxidative Stress with Polyphenols to Fight Liver Diseases". Antioxidants (2023): https://doi.org/10.3390/antiox12061212.
    10.3390/antiox12061212
  10. Cátia R. Lopes; Joana S. Silva; Joana Santos; Matilde S. Rodrigues; Daniela Madeira; Andreia Oliveira; Ana Moreira-de-Sá; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/8/6968.
    10.3390/ijms24086968
  11. Ivo F. Machado; Carlos M. Palmeira; Anabela P. Rolo. "Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury". Biomedicines (2023): https://doi.org/10.3390/biomedicines11030948.
    10.3390/biomedicines11030948
  12. Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T.; Amorim, João A.; Bonkowski, Michael S.; Apostolides, John K.; Salfati, Elias L.; et al. "Loss of epigenetic information as a cause of mammalian aging". Cell 186 2 (2023): 305-326.e27. http://dx.doi.org/10.1016/j.cell.2022.12.027.
    10.1016/j.cell.2022.12.027
  13. Raquel G. Bardallo; Rui T. Da Silva; Teresa Carbonell; Carlos Palmeira; Emma Folch-Puy; Joan Roselló-Catafau; René Adam; Arnau Panisello-Rosello. "Liver Graft Hypothermic Static and Oxygenated Perfusion (HOPE) Strategies: A Mitochondrial Crossroads". International Journal of Molecular Sciences 23 10 (2022): 5742-5742. https://doi.org/10.3390/ijms23105742.
    10.3390/ijms23105742
  14. "The Use of a Single, Novel Preservation Solution in Split Liver Transplantation and Hypothermic Oxygenated Machine Perfusion". Transplantation 106 3 (2022): e187-e188.
    Publicado
  15. João S. Teodoro; Rui T. Da Silva; Ivo F. Machado; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira. "Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria". Cells 11 4 (2022): 688-688. https://doi.org/10.3390/cells11040688.
    10.3390/cells11040688
  16. Amorim, João A.; Coppotelli, Giuseppe; Rolo, Anabela P.; Palmeira, Carlos M.; Ross, Jaime M.; Sinclair, David A.. "Mitochondrial and metabolic dysfunction in ageing and age-related diseases". Nature Reviews Endocrinology (2022): http://dx.doi.org/10.1038/s41574-021-00626-7.
    10.1038/s41574-021-00626-7
  17. Rui Teixeira da Silva; Ivo F. Machado; João S. Teodoro; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira. "PEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury". International Journal of Molecular Sciences 23 3 (2022): 1156-1156. https://doi.org/10.3390/ijms23031156.
    10.3390/ijms23031156
  18. Rui Teixeira Da Silva; Raquel G. Bardallo; Emma Folch-Puy; Teresa Carbonell; Carlos M. Palmeira; Constantino Fondevila; René Adam; Joan Roselló-Catafau; Arnau Panisello-Roselló. "IGL-2 as a Unique Solution for Cold Static Preservation and Machine Perfusion in Liver and Mitochondrial Protection". Transplantation Proceedings 54 1 (2022): 73-76. https://doi.org/10.1016/j.transproceed.2021.10.008.
    10.1016/j.transproceed.2021.10.008
  19. Sara Nunes; Sofia D. Viana; Inês Preguiça; André Alves; R. Fernandes; Teodoro, J.S.; Patrícia Matos; et al. "Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics". Nutrients (2021): https://www.mdpi.com/2072-6643/13/12/4192.
    10.3390/nu13124192
  20. Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Amorim, João A.; Jarak, Ivana; Carvalho, Rui A.; Palmeira, Carlos M.; Rolo, Anabela P.. "Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown". International Journal of Molecular Sciences 22 21 (2021): 11738. http://dx.doi.org/10.3390/ijms222111738.
    10.3390/ijms222111738
  21. Piochi, Luiz F.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P.. "Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation". Ageing Research Reviews 67 (2021): 101309. http://dx.doi.org/10.1016/j.arr.2021.101309.
    10.1016/j.arr.2021.101309
  22. Oliveira, Raúl P.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P.. "The potential role of sestrin 2 in liver regeneration". Free Radical Biology and Medicine 163 (2021): 255-267. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.027.
    10.1016/j.freeradbiomed.2020.12.027
  23. Machado, Ivo F.; Teodoro, João S.; Castela, Ana C.; Palmeira, Carlos M.; Rolo, Anabela P.. "miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia". International Journal of Molecular Sciences 22 2 (2021): 541. http://dx.doi.org/10.3390/ijms22020541.
    10.3390/ijms22020541
  24. Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; et al. "Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats". Pharmaceutics 12 11 (2020): 1094. http://dx.doi.org/10.3390/pharmaceutics12111094.
    10.3390/pharmaceutics12111094
  25. João S. Teodoro; Rui Silva; António Aguiar; Abílio J. F. N. Sobral; Anabela P. Rolo; Carlos M. Palmeira. "Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product cis-2-butene-1,4-dial on human and rat hepatocytes". Toxicology Mechanisms and Methods 30 7 (2020): 536-545. https://doi.org/10.1080/15376516.2020.1780361.
    10.1080/15376516.2020.1780361
  26. Teodoro, João S.; Amorim, João A.; Machado, Ivo F.; Castela, Ana C.; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabela P.; Palmeira, Carlos M.. "The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function". International Journal of Molecular Sciences 21 14 (2020): 4896. http://dx.doi.org/10.3390/ijms21144896.
    10.3390/ijms21144896
  27. Makrecka-Kuka, M.; Liepinsh, E.; Murray, A.J.; Lemieux, H.; Dambrova, M.; Tepp, K.; Puurand, M.; et al. "Altered mitochondrial metabolism in the insulin-resistant heart". Acta Physiologica 228 3 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077842678&partnerID=MN8TOARS.
    10.1111/apha.13430
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  97. Varela AT; Simões AM; Teodoro JS; Duarte FV; Gomes AP; Palmeira CM; Rolo AP. "Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3beta and mitochondrial permeability transition.". (2010): http://europepmc.org/abstract/med/20433952.
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  98. Carvalho RA; Sousa RP; Cadete VJ; Lopaschuk GD; Palmeira CM; Bjork JA; Wallace KB. "Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy.". (2010): http://europepmc.org/abstract/med/20132857.
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  99. Simões AM; Duarte FV; Teodoro JS; Rolo AP; Palmeira CM. "Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and tetraethyl lead affects lung mitochondria bioenergetics.". (2010): http://europepmc.org/abstract/med/20158383.
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  102. Rolo AP; Palmeira CM; Cortopassi GA. "Biosensor plates detect mitochondrial physiological regulators and mutations in vivo.". (2009): http://europepmc.org/abstract/med/18950600.
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  103. Teodoro JS; Rolo AP; Duarte FV; Simões AM; Palmeira CM. "Differential alterations in mitochondrial function induced by a choline-deficient diet: understanding fatty liver disease progression.". (2008): http://europepmc.org/abstract/med/18765303.
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  105. Alves TC; Nunes PM; Palmeira CM; Jones JG; Carvalho RA. "Estimating gluconeogenesis by NMR isotopomer distribution analysis of [13C]bicarbonate and [1-13C]lactate.". (2008): http://europepmc.org/abstract/med/17683055.
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  106. La-Salete R; Oliveira MM; Palmeira CA; Almeida J; Peixoto FP. "Mitochondria a key role in microcystin-LR kidney intoxication.". (2008): http://europepmc.org/abstract/med/17461434.
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  107. Peixoto, F.; Martins, F.; Amaral, C.; Gomes-Laranjo, J.; Almeida, J.; Palmeira, C.M.. "Evaluation of olive oil mill wastewater toxicity on the mitochondrial bioenergetics after treatment with Candida oleophila". Ecotoxicology and Environmental Safety 70 2 (2008): 266-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049108014&partnerID=MN8TOARS.
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  108. Palmeira CM; Rolo AP; Berthiaume J; Bjork JA; Wallace KB. "Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis.". (2007): http://europepmc.org/abstract/med/17761203.
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  110. Teodoro J; Rolo AP; Oliveira PJ; Palmeira CM. "Decreased ANT content in Zucker fatty rats: relevance for altered hepatic mitochondrial bioenergetics in steatosis.". (2006): http://europepmc.org/abstract/med/16554051.
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  167. Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C.. "Effects of paraquat, dinoseb and 2,4-D on intracellular calcium and on vasopressin-induced calcium mobilization in isolated hepatocytes". Archives of Toxicology 69 7 (1995): 460-466. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029054234&partnerID=MN8TOARS.
    10.1007/s002040050199
  168. Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C.. "Metabolic alterations in hepatocytes promoted by the herbicides paraquat, dinoseb and 2,4-D". Archives of Toxicology 68 1 (1994): 24-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028009773&partnerID=MN8TOARS.
    10.1007/s002040050025
  169. Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C.. "Interactions of herbicides 2,4-D and dinoseb with liver mitochondrial bioenergetics". Toxicology and Applied Pharmacology 127 1 (1994): 50-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028146853&partnerID=MN8TOARS.
    10.1006/taap.1994.1138
  170. Palmeira, C.M.; Santos, M.S.; Carvalho, A.P.; Oliveira, C.R.; Palmeira CM; Santos MS; Carvalho AP; Oliveira CR. "Membrane lipid peroxidation induces changes in ¿-[3H]aminobutyric acid transport and calcium uptake by synaptosomes". Brain Research 609 1-2 (1993): 117-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027309463&partnerID=MN8TOARS.
    10.1016/0006-8993(93)90863-I
  171. Palmeira, C.M.; Oliveira, C.R.. "Partitioning and membrane disordering effects of dopamine antagonists: Influence of lipid peroxidation, temperature, and drug concentration". Archives of Biochemistry and Biophysics 295 1 (1992): 161-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026729101&partnerID=MN8TOARS.
    10.1016/0003-9861(92)90502-N
Capítulo de livro
  1. Duarte, Ana I.; Sadowska-Bartosz, Izabela; Karkucinska-Wieckowska, Agnieszka; Lebiedzinska-Arciszewska, Magdalena; Palmeira, Carlos M.; Rolo, Anabela P.; Kabiri, Yaschar; et al. "A metabolic and mitochondrial angle on aging". In Aging, editado por Oliveira PJ; Malva JO, 175-256. Elsevier, 2023.
    Publicado • 10.1016/b978-0-12-823761-8.00024-0
  2. Teodoro, João Soeiro; Rolo, Anabela Pinto; Palmeira, Carlos Manuel Marques. "Mitochondrial Bioenergetic Assays as a Standard Protocol for Toxicological and Metabolic Assessment". In Methods in Molecular Biology, 231-241. Springer US, 2021.
    10.1007/978-1-0716-1091-6_16
  3. Machado, Ivo F.; Teodoro, João S.; Castela, Ana C.; Palmeira, Carlos M.; Rolo, Anabela P.. "Mitohormesis". In Mitochondrial Physiology and Vegetal Molecules, 729-746. Elsevier, 2021.
    Publicado • 10.1016/b978-0-12-821562-3.00035-6
  4. Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Rolo, Anabela P.; Palmeira, Carlos M.. "The Evaluation of Mitochondrial Membrane Potential Using Fluorescent Dyes or a Membrane-Permeable Cation (TPP+) Electrode in Isolated Mitochondria and Intact Cells". In Methods in Molecular Biology, 197-213. Springer US, 2020.
    10.1007/978-1-0716-0802-9_14
  5. Alexandrino, H.; Rolo, A.; Tralhão, J.G.; Castro e Sousa, F.; Palmeira, C.; Alexandrino, Henrique; Rolo, Anabela; et al. "Mitochondria in liver regeneration: Energy metabolism and posthepatectomy liver dysfunction". In Mitochondrial Biology and Experimental Therapeutics, 127-152. Springer International Publishing, 2018.
  6. Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P.; Palmeira CM; Rolo AP. "Mitochondrial membrane potential (¿¿) fluctuations associated with the metabolic states of mitochondria". 109-119. 2018.
    10.1007/978-1-4939-7831-1_6
  7. Teodoro, João Soeiro; Palmeira, Carlos Marques; Rolo, Anabela Pinto. "Mitochondrial Membrane Potential (¿¿) Fluctuations Associated with the Metabolic States of Mitochondria". In Methods in Molecular Biology, 109-119. Springer New York, 2018.
    10.1007/978-1-4939-7831-1_6
  8. Amorim, Joao Alves; Teodoro, Joao Soeiro; Palmeira, Carlos Marques; Rolo, Anabela Pinto. "Sirtuins and Bile Acids: Potential Anti-obesity Strategies Targeting Mitochondria". In Anti-Obesity Drug Discovery and Development: Volume 4, 57-97. BENTHAM SCIENCE PUBLISHERS, 2018.
    10.2174/9781681085586118040005
  9. Palmeira, C.M.; Ramalho-Santos, J.. "Mitochondrial dysfunction in reproductive and developmental toxicity". 1023-1035. 2017.
    10.1016/B978-0-12-382032-7.10061-X
  10. Teodoro, João S.; Duarte, Filipe V.; Rolo, Anabela P.; Palmeira, Carlos M.. "Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals". In Nutraceuticals, 387-400. Elsevier, 2016.
    10.1016/b978-0-12-802147-7.00028-0
  11. Duarte, Filipe V.; Palmeira, Carlos M.; Rolo, Anabela P.; Duarte FV; Palmeira CM; Rolo AP. "The Emerging Role of MitomiRs in the Pathophysiology of Human Disease". In Advances in Experimental Medicine and Biology, 123-154. Springer International Publishing, 2015.
    10.1007/978-3-319-22671-2_8
  12. Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P.; Teodoro JS; Palmeira CM; Rolo AP; Teodoro, João S.; Palmeira, Carlos M.; Rolo, Anabela P.. "Determination of oxidative phosphorylation complexes activities". In Methods in Molecular Biology, 71-84. Springer New York, 2014.
    10.1007/978-1-4939-1875-1_7
  13. Palmeira, Carlos M.; Duarte, Filipe V.; Teodoro, João S.; Varela, Ana T.; Rolo, Anabela P.; Palmeira, C.M.; Duarte, F.V.; et al. "Biomarkers of mitochondrial dysfunction and toxicity". In Biomarkers in Toxicology, 847-861. Elsevier, 2014.
    10.1016/b978-0-12-404630-6.00051-8
  14. Palmeira, Carlos M.; Rolo, Anabela P.. "Mitochondrial Membrane Potential (¿¿) Fluctuations Associated with the Metabolic States of Mitochondria". In Methods in Molecular Biology, 89-101. Humana Press, 2011.
    10.1007/978-1-61779-382-0_6
  15. Costa, Sonia; Martinho, Filipe; Palmeira, Carlos; Pardal, Miguel A. "Overfishing, aquaculture and the problem of food quality – a case study for portuguese students". In Science and Environmental Education, 269-282. Peter Lang GmbH, 2008.
    Publicado
Edição de livro
  1. Palmeira, Carlos M., ed. Mitochondrial Bioenergetics. Springer New York. 2018.
    10.1007/978-1-4939-7831-1
  2. Palmeira, Carlos M., ed. Mitochondrial Regulation. Springer New York. 2015.
    10.1007/978-1-4939-1875-1
  3. Palmeira, Carlos M., ed. Mitochondrial Bioenergetics. Humana Press. 2012.
    10.1007/978-1-61779-382-0
Edição de número de revista
  1. Palmeira, Carlos M.. "Metabolic Diseases: Drugs and Mitochondrial Targets". Current Medicinal Chemistry 22 20 (2015): http://www.eurekaselect.com/node/602/current-medicinal-chemistry/issue/22/1553/20/6495.
    Publicado • Editor
Livro
  1. Palmeira, C.M.; Moreno, A.J.. Preface. 2018.
  2. Teodoro, J.S.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M.. Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals. 2016.
    10.1016/B978-0-12-802147-7.00028-0
  3. Palmeira, C.M.; Rolo, A.P.. Preface. 2014.
  4. Palmeira, C.M.; Rolo, A.P.. Mitochondrial Regulation: Methods and Protocols. 2014.
    10.1007/978-1-4939-1875-1
Poster em conferência
  1. Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Jarak, Ivana; Carvalho, Rui A.; et al. "Blueberry juice prevents prediabetes progression in a hypercaloric diet-induced rat model through the modulation of hepatic mitochondrial bioenergetics and metabolic pathways.". Trabalho apresentado em 1º Congresso da Rede de Instituições do Ensino Superior para a Salvaguarda da Dieta Mediterrânica, 2021.
  2. Nunes, Sara; Sofia D. Viana; Preguiça, Inês; Alves, André; Rolo, Anabela P.; Palmeira, Carlos M.; Cavadas, Claudia; Maria Manuela Estevez Pintado; Flávio Reis. "O sumo de mirtilo previne a esteatose hepática pré-diabética em ratos alimentados com dieta hipercalórica.". Trabalho apresentado em VI Colóquio nacional da produção de pequenos frutos, 2021.
  3. Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Jarak, Ivana; Carvalho, Rui A.; et al. "Hepatoprotective effects of blueberry juice in a prediabetic rat model induced by a hypercaloric diet - a molecular aproach.". Trabalho apresentado em 17º Congresso Português de Diabetes, Vilamoura 11-17 Março 2021, 2021.
  4. Nunes, Sara; Viana, Sofia D.; Alves, André; Preguiça, Inês; Fernandes, Rosa; Rolo, Anabela Pinto; Palmeira, Carlos; et al. "Impacto de uma estratégia não-farmacológica na disfunção hepática pré-diabética - estudo do sumo de mirtilos em ratos alimentados com dieta hipercalórica.". Trabalho apresentado em 16.º Congresso Português de Diabetes, Vilamoura, Portugal, 2020.
  5. Machado, Ivo F.; Teodoro, João S.; Palmeira, Carlos M.; Rolo, Anabela P.. "Modulation of complex I and oxidative capacity in cells under metabolic stress". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
    10.1111/eci.13109
  6. Amorim, João; Thakur, Sachin; Bonkowski, Michael S; Rolo, Anabela P.; Palmeira, Carlos M.; Sinclair, David A.. "An activation-defective mouse mutant as a model to unravel the mechanisms of SIRT1 activators". Trabalho apresentado em Mechanisms of Aging | CSHL - Cold Spring Harbor Laboratory, 2018.
  7. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A.; Palmeira, Carlos M.. "Modification of mitochondria in glutamatergic nerve terminals in early Alzheimer's disease". Trabalho apresentado em Mitochondrial DNA and neurodegeneration, 2015.
  8. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A; Palmeira, Carlos M.. "Altered mitochondria membrane potential in glutamatergic terminals associated with synaptic loss in an in vitro animal model of early Alzheimer's disease". Trabalho apresentado em 25th Biennial Meeting of the International Society for Neurochemistry, 2015.
  9. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A.; Palmeira, Carlos M.. "Predominant susceptibility of mitochondrial membrane potential from glutamatergic nerve terminals in an in vitro model of early Alzheimer’s disease". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neurosciences, 2015.
  10. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A.; Palmeira, Carlos M.. "Glutamatergic nerve terminals display altered mitochondria in an animal model of early Alzheimer's disease". Trabalho apresentado em Portuguese Society of Biochemistry, 2014.
  11. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A.; Palmeira, Carlos M.. "Mitochondria in glutamatergic nerve terminals are selectively affected by exposure to Aß1-42 modeling early Alzheimer's disease". Trabalho apresentado em MITOBRAIN: Mitochondrial Functions and Dysfunctions in the CNS, 2014.
  12. Oliveira, Paulo; Rolo, Anabela P.; Coxito, Pedro; Santos, Dario L.; Sardão, Vilma; Seiça, Raquel; Monteiro, Pedro; et al. "Mitochondria From Diabetic Rats Cardiomyocytes are more resistent to the Induction of Permeability Transition Pore". Trabalho apresentado em 2nd European Meeting on Vascular Biology and Medicine, ULM, German, 2001.
  13. Oliveira, Paulo; Rolo, Anabela P.; Seiça, Raquel; Sardão, Vilma; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; et al. "Heart Mitochondria From Diabetic Rats Are More Resistant to the Induction of the Mitochondrial Permeability Transition". Trabalho apresentado em XXII Congresso Português de Cardiologia, Vilamoura, Portugal, 2001.
Resumo em conferência
  1. Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Jarak, Ivana; Carvalho, Rui A.; et al. "Unraveling the hepatoprotective effects of blueberries in a hypercaloric diet-induced rat model of prediabetes by metabolomic and transcriptomic approaches.". Trabalho apresentado em Annual Meeting 2021 Coimbra Heath School - Global Health: New Trends, published in European Journal of Public Health, Volume 31, Issue Supplement 2, Coimbra, 2021.
    Publicado • 10.1093/eurpub/ckab120.106
  2. Machado, Ivo F.; Teodoro, João S.; Palmeira, Carlos M.; Rolo, Anabela P.. "Interplay between metformin and miR-378a-3p in cells under hyperglycaemia". Trabalho apresentado em 12th MiP/MitoEAGLE Training School, 2019.
    10.26124/mitofit:ea19.mipschool.0008
  3. Teodoro, João S.; Rolo, Anabela P.; Da Silva, Rui T.; Machado, Ivo F.; Rosello-Catafau, Joan; Steegborn, Clemens; Palmeira, Carlos M.. "Novel avenues of ischemia/reperfusion injury prevention: lessons from a soluble adenylyl cyclase inhibitor and a SirT3 activator". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
    10.1111/eci.13108
  4. Nunes, Sara; S.D. Viana; Rolo, Anabela Pinto; Palmeira, Carlos M.; André, MA; Cavadas, Claudia; Pintado, Maria Manuela; Reis, Flávio. "Blueberry juice as a nutraceutical approach to prevent prediabetes progression in an animal model - Focus on hepatic steatosis.". Trabalho apresentado em Annual meeting 2019. “Primary health care: Challenges and Oportunities; Abstract published in European Journal of Public Health, Vol. 29, Supplement 1, 2019., Coimbra, 2019.
    Publicado • 10.1093/eurpub/ckz034.011
  5. Nunes, Sara; Viana SD; Rolo, Anabela Pinto; Palmeira, Carlos; André, MA; Cavadas, Claudia; Pintado, Maria Manuela; Reis, Flávio. "Effects of blueberry juice intake on liver injury progression in a hypercaloric diet-induced prediabetic rat model". Trabalho apresentado em 12th MiP/MitoEAGLE Training School, Coimbra, 2019.
  6. Nunes, Sara; Viana SD; Castela, Ana; Rolo, Anabela Pinto; Palmeira, Carlos; André, MA; Cavadas, Claudia; Pintado, MM; Reis, Flávio. "Blueberry juice attenuates liver injury progression in a rat model of diet-induced prediabetes". Trabalho apresentado em 1st Meeting in Translational Pharmacology (38th Spanish Society of Pharmacology meeting/9th Spanish Society of Pharmacogenetics and Pharmacogenomics meeting), Santiago de Compostela, 2018.
    Publicado • https://doi.org/10.1111/bcpt.13084
  7. Alexandrino, Henrique Miguel Marques Bom Borges; Varela, Ana T.; Ferreira, Luís; Martins, R.; Filipe V. Duarte; Teodoro, João Soeiro; Serôdio, M.; et al. "Disfunção Bioenergética em Cirurgia Hepática: Factor Determinante na Função Hepatocelular após Hepatectomia?". Trabalho apresentado em XXXV Congresso Nacional de Cirurgia, Figueira da Foz, 2015.
    Publicado
  8. Alexandrino, Henrique Miguel Marques Bom Borges; Varela, Ana T.; Oliveira, R.C.; João Cardoso; Filipe V. Duarte; Teodoro, João Soeiro; Rolo, Anabela P.; et al. "Hepatotoxicidade da Quimioterapia: Validação de um Modelo Animal". Trabalho apresentado em XXXV Congresso Nacional de Cirurgia, Figueira da Foz, 2015.
    Publicado
  9. Alexandrino, Henrique Miguel Marques Bom Borges; Varela, Ana T.; Cipriano, Maria Augusta; Filipe V. Duarte; Teodoro, João Soeiro; Ferreira, Luís; Rolo, Anabela P.; et al. "Avaliação da Função Mitocondrial em Modelo Animal de Hepatectomia Major com Clampagem do Pedículo Hepático". Trabalho apresentado em XXXIV Congresso Nacional de Cirurgia, Albufeira, 2014.
    Publicado
  10. Remiao, Fernando; Rossato, Luciana Grazziotin; Dallegrave, Eliane; Arbo, Marcelo; Silva, Renata; Ferreira, Rita; Amado, Francisco; et al. "Mitochondrial impairment after mitoxantrone multi-administration to male Wistar rats". 2013.
    10.1016/j.toxlet.2013.05.373
  11. Francisco Peixoto; Santos, Dario J.S.L.; Barao, Ana; Palmeira, Carlos M.; Rocha, Silvia M.; Coimbra, Manuel A.. "Nerolidol disturbs mitochondrial bioenergetics but delays the permeability transition pore due a membrane antioxidant protective effect". 2011.
    Publicado • 10.1016/j.bbabio.2008.05.252
Tese / Dissertação
  1. Pereira, Cláudia Maria Fragão; Palmeira, Carlos. "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors". Doutoramento, 2011. http://hdl.handle.net/10316/18243.
  2. Palmeira, Carlos M.. "Alterações metabólicas em células hepáticas de rato induzidas por herbicidas de uso generalizado". Doutoramento, Universidade de Coimbra, 1995. https://estudogeral.sib.uc.pt/handle/10316/2126?mode=full.

Outros

Outra produção
  1. Bile acids are toxic for isolated cardiac mitochondria. Abstract Cholestasis and other liver diseases may affect the heart through the toxic effects of the retained bile acids on cardiac mitochondria, which could explain the origin of hepatic-derived cardiomyopathies. The objective of this work was to test the hypothesis that bile acids are toxic to heart mitochondria for concentrations that are relevant for cholestasis. Heart mitochondria were isolate. 2005. Ferreira, Manuela; Coxito, Pedro; Sardão, Vilma; Palmeira, Carlos; Oliveira, Paulo. http://hdl.handle.net/10316/7824.
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - Atual PhD - Genes codificantes e RNAs longos não codificantes na rejeição mediada por células T de fígado transplantado em idade pediátrica.
Coorientador
 Ciências da Saúde (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - Atual PhD - Predictive factors for non-anastomotic biliary strictures after liver ransplantation: prospective analysis of histological lesion and mitochondrial function of the bile duct in response to ischemia / re-perfusion. identification of new criteria for classification of marginality of the liver graft
Coorientador
 Ciências da Saúde (Doutoramento)
Universidade de Coimbra, Portugal
2020 - 2025 PhD - Understanding the Mechanisms of Ageing and Age Reversal
Coorientador
 Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2018 - 2024 PhD - Effects of drugs on epicardial tissue - impact on cardiac function
Coorientador
 Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2024 PhD - The physiology and health condition of urban dweller gulls in increasingly urbanized areas
Coorientador
 Biociências (Doutoramento)
Universidade de Coimbra, Portugal
2016 - 2019 PhD - Understanding the underlying mechanisms regulating aging and longevity
Coorientador
 Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra, Portugal
2015 - 2018 PhD - Liver transplantation: new prognostic factors of the regulation of mitochondrial function in ischemia/reperfusion
Coorientador
 Ciências da Saúde (Doutoramento)
Universidade de Coimbra, Portugal
2014 - 2018 PhD - Energy for Liver Regeneration: Mitochondrial Bioenergetics and the Pathogenesis of Posthepatectomy Liver Dyfunction
Coorientador
 Ciências da Saúde (Doutoramento)
Universidade de Coimbra, Portugal
2013 - 2016 PostDoc - Joao Soeiro Terra Teodoro (SFRH/BPD/94036/2013)
Coorientador
 SFRH/BPD/94036/2013 (Outra)
2013 - 2016 PostDoc - Filipe Valente Duarte (SFRH/BPD/94898/2013)
Coorientador
 SFRH/BPD/94898/2013 (Outra)
2013 - 2016 PostDoc - Ana Teresa Inácio Ferreira Varela (SFRH/BPD/94886/2013)
Coorientador
 SFRH/BPD/94886/2013 (Outra)
2011 - 2014 PhD - The cardiotoxicity of mitoxantrone: a mechanistic approach using in vitro and in vivo models.
Coorientador
 Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2009 - 2013 PhD - Unravelling new roles for SIRT1 in mitochondrial biology
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra, Portugal
2009 - 2012 PostDoc - Joana Luísa Lourenço Estevinho Pereira (SFRH/BPD/44733/2008)
Coorientador
 SFRH/BPD/44733/2008 (Outra)
2009 - 2012 PhD - Physiologic pathways and molecular mechanisms regulating energy homeostasis in diabetes
Coorientador
 Biociências (Doutoramento)
Universidade de Coimbra, Portugal
2009 - 2012 PhD - Regulation of mitochondrial function in ischemia/reperfusion: looking for therapeutic strategies in fatty livers
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra, Portugal
2009 - 2012 PhD - Effects of exposition to dioxins and environmental pollutants: identification of biomarkers in chronic pulmonary diseases
Coorientador
 Biociências (Doutoramento)
Universidade de Coimbra, Portugal
2008 - 2011 PhD - Impacto da diabetes e sua terapêutica na função cardiomiocitária na isquémia-reperfusão: estudo em modelos animais e em doentes com insuficiência cardíaca avançada
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra, Portugal
2008 - 2011 PhD - The Effects of Environmental Conditions and Mercury on Common Estuarine Species. An Integrated Ecological and Toxicological Approach
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra, Portugal
2007 - 2011 PhD - NMR studies on the regulation of glucose and fatty acid oxidation in liver, heart and skeletal muscle in awake rats
Coorientador
 Bioquímica (Doutoramento)
Universidade de Coimbra, Portugal
2007 - 2011 PhD - Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra, Portugal
2007 - 2010 PostDoc - Pedro Emanuel Pato Martins (SFRH/BPD/35068/2007)
Coorientador
 SFRH/BPD/35068/2007 (Outra)
2008 - 2009 PostDoc - João Gonçalo Leal de Oliveira e Silva Frade (SFRH/BPD/66253/2009)
Orientador de João Gonçalo Leal de Oliveira e Silva Frade
SFRH/BPD/66253/2009 (Outra)
Universidade de Coimbra, Portugal
2003 - 2009 PostDoc - Anabela Pinto Rolo (SFRH/BPD/14615/2003 and SFRH/BPD/26514/2006)
Orientador de Anabela Pinto Rolo
 SFRH/BPD/14615/2003 and SFRH/BPD/26514/2006 (Outra)
2002 - 2006 PhD - Avaliação do efeito de extractos de plantas a nível da bioenergética mitocondrial em ratos diabéticos
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra, Portugal
2000 - 2003 PhD - Cholestasis and hepatic ischemia: bile acids therapy. Cellular mechanisms with relevance to mitochondrial function
Orientador de Anabela Pinto Rolo
 Biologia (Doutoramento)
Universidade de Coimbra, Portugal
2000 - 2003 PhD - Cardiac mitochondrial function:studies on the impact of disease conditions and on the protection afforded by carvedilol
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2016 - Atual Perito A3ES
Avaliador
 A3ES, Portugal
2025 - 2025 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2025 (FCT) Painel de avaliação: Biologia Experimental e Bioquímica
Avaliador
2024 - 2024 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2024 (FCT) Painel de avaliação: Biologia Experimental e Bioquímica
Avaliador
2023 - 2023 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2023 (FCT) Painel de avaliação: Biologia Experimental e Bioquímica
Avaliador
2015 - 2015 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2015 (FCT) Painel de avaliação: Ciências do Ambiente (Co-coordenador)
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2014 - 2014 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2014 (FCT) Painel de avaliação: Ciências Ambientais e outras ciências naturais
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2013 - 2013 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2013 (FCT) Painel de avaliação: Biomedicina
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal

Membro de associação

Nome da associação Tipo de participação
2015 - Atual Mitochondrial Physiology Society Membro
2000 - Atual Sociedade Portuguesa de Bioquímica Membro
2000 - Atual Society of Tozixology Membro

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2015 - Atual Membro do Comité Executivo da Mitochondrial Physiology Society (desde 2015)
Vogal
 Mitochondrial Physiology Society , Áustria