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Identificação

Identificação pessoal

Nome completo
Patricia Pitrez

Nomes de citação

  • Pitrez, Patricia R.

Identificadores de autor

Ciência ID
9A16-124B-5A17
ORCID iD
0000-0002-3116-0723

Moradas

  • UC Biotech . Technological Park of Cantanhede Nucleo 4, Lote 8 , 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Português (Idioma materno)
Formação
Grau Classificação
2018/10 - 2023/07
Em curso
 New senotherapeutic platforms for vascular senescent cells. Bioengineering platforms for vascular cells derived from Hutchinson-Gilford progeria syndrome (HGPS) inducible pluripotent stem cells. (Pós-doutoramento)
CNC.IBILI, Portugal
2022/09 - 2022/10
Concluído
 How age and environmental factors affect cardiac cells at the molecular level (Pós-doutoramento)
Leibniz Institute on Aging, Alemanha
2020/11 - 2021/01
Concluído
 Testing the effect of senolytic formulations in a senescent mouse model (Pós-doutoramento)
University of Niigata, Japão
2016/11 - 2018/09
Concluído
 Bioengineering platforms to modulate the activity of smooth muscle cells derived from Progeria induced pluripotent stem cells (Pós-doutoramento)
IBILI - Faculty of Medicine (FMUC). University of Coimbra. Coimbra. Portugal, Portugal
2010 - 2016
Concluído
 MIT Portugal Program - Bioengineering (Doutoramento)
Universidade do Minho Escola de Engenharia, Portugal
"Bioengineering Platforms to Modulate the Activity of Smooth Muscle Cells Derived from Progeria-Induced Pluripotent Stem Cells" (TESE/DISSERTAÇÃO)
 Muito Bom
2009/01 - 2009/09
Concluído
 Study under the scope of the Erasmus Placement program. Novo Nordisk A/S, Copenhagen (Mestrado integrado)
Novo Nordisk A/S, Dinamarca
"Monitoring of Glucose and Lactate Concentrations in Mammalian Cultivations using Mid-IR Spectroscopy" (TESE/DISSERTAÇÃO)
 18
2004/09 - 2009/07
Concluído
 Biological Engineering (Licenciatura)
Universidade do Minho Escola de Engenharia, Portugal
"Integrated Master Program in Biological Engineering" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/11/01 - Atual Posdoctoral Researcher. Research topic/area: New senotherapeutic platforms for vascular senescent cells. Bioengineering platforms for vascular cells derived from Progeria iPSCs UC Biotech - Center for Neuroscience and Cell Biology. Cantanhede. Portugal, Portugal
2022/09 - 2022/10 Posdoctoral Researcher. Research topic/area: how age and environmental factors affect cardiac cells at the molecular level Leibniz Institute on Aging, Alemanha
Leibniz Institute on Aging, Alemanha
2020/11 - 2021/01 Posdoctoral Researcher. Research topic/area: Testing the effect of senolytic formulations in a senescent mouse model University of Niigata, Japão
2016/11/01 - 2018/10/31 Posdoctoral Fellowship. Research topic/area: Bioengineering platforms to modulate the activity of smooth muscle cells derived from Progeria induced pluripotent stem cells. IBILI - Faculty of Medicine (FMUC). University of Coimbra. Coimbra. Portugal, Portugal
2014/11/01 - 2016/10/31 Assistant Researcher (BI - Bolsa de Investigação). Research topic/area: Vascular cells derived from Hutchinson-Gilford progeria syndrome (HGPS) inducible pluripotent stem cells UC Biotech - Center for Neuroscience and Cell Biology. Cantanhede. Portugal, Portugal
2010/09/01 - 2014/09/30 PhD student. MIT-Portugal Doctoral Program Bioengeneering Systems Area. Research topic/area: Vascular cells derived from Hutchinson-Gilford progeria syndrome (HGPS) inducible pluripotent stem cells University of Coimbra, Technical University of Lisbon, New University of Lisbon and University of Minho. , Portugal
2010/01/15 - 2010/08/31 Assistant Researcher (BI - Bolsa de Investigação) - Research on the development of keratin films from poultry feathers and ox hair. Faculty of Engineering of the University of Porto, Department of Chemical Engineering., Portugal
2009/02/01 - 2009/08/31 Work / study under the scope of the Erasmus Placement program - Research on monitoring of glucose and lactate concentrations in mammalian cell cultures using mid-infrared spectroscopy. Novonordisk, Dinamarca
Projetos

Bolsa

Designação Financiadores
2022/01/22 - 2023/07/21 Cardiac ageing through the lens of Hutchinson-Gilford Progeria Syndrome
EXPL/MED-OUT/1205/2021
Investigador responsável
Universidade de Coimbra, Portugal
Em curso

Projeto

Designação Financiadores
2022/02/15 - Atual A therapeutic strategy to fight Blood-brain barrier (BBB) ageing
PTDC/BTM-SAL/5174/2020
Investigador
Em curso
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/09/06 - 2022/01/21 BrainEdition: remotely controlling gene edition in neural stem cells
CENTRO-01-0145-FEDER-028060
Investigador
Concluído
2018/11/01 - 2021/07/21 An iPSC-derived vascular model of Progeria to identify mediators for smooth muscle loss
PTDC/BTM-SAL/29229/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016 - 2018 ERA Chair: Enhancing Research in Ageing at the University of Coimbra.
ERA@UC. Ref. 669088 - 2.5 M
ERA@UC. Ref. 669088 - 2.5 M
ERA@UC. Ref. 669088 - 2.5 M¿
Bolseiro de Pós-Doutoramento
N/A
Concluído
2013 - 2015 To unravel the vulnerability of Progeria smooth muscle cells- Smooth_Progeria
EXPL/BIM-MED/2267/2013 - 49.800,00
EXPL/BIM-MED/2267/2013 - 49.800,00
EXPL/BIM-MED/2267/2013 - ¿ 49.800,00
 N/A
Concluído
2012 - 2015 Personalized 3D vascular constructs for toxicity assessment- VASCTOX
PTDC/SAU-TOX/121887/2010 - 141.755,00
PTDC/SAU-TOX/121887/2010 - 141.755,00
PTDC/SAU-TOX/121887/2010 - ¿ 141.755,00
 N/A
Concluído

Outro

Designação Financiadores
2013 - 2015 StemCell_Biotech
QREN
Concluído
Produções

Publicações

Artigo em boletim informativo
  1. Pitrez, Patricia R.; Maria do Carmo Cachulo. Autor correspondente: Pitrez, Patricia R.. "Perceber o envelhecimento cardíaco através de uma doença rara", Portuguese Foundation of Cardiology, 2023
Artigo em conferência
  1. Pitrez, Patricia R.; Vazão, Helena; Nissan, Xavier; Ferreira, Lino; Rocha, I.. "Vascular cells derived from Hutchinson-Gilford progeria syndrome (HGPS) inducible pluripotent stem cells". 2014.
Artigo em revista
  1. Pitrez, Patricia R.. "Pharmacological clearance of senescent cells with Navitoclax reverses HFpEF hallmarks by decreasing inflammation, endothelial dysfunction and cardiac fibrosis". JCI (2024): https://europepmc.org/article/ppr/ppr366086.
    Em revisão
  2. Patricia R. Pitrez; Luis M. Monteiro; Oliver Borgogno; Xavier Nissan; Jerome Mertens; Lino Ferreira. "Cellular reprogramming as a tool to model human aging in a dish". Nature Communications (2024): https://doi.org/10.1038/s41467-024-46004-5.
    10.1038/s41467-024-46004-5
  3. Pitrez, Patricia R.. "Differentiation of human induced-pluripotent stem cells into smooth muscle cells". Protocol Exchange (2021):
    Publicado
  4. Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al. "Induced pluripotent stem cell-derived vascular networks to screen nano-bio interactions". Nanoscale Horizons 6 3 (2021): 245-259. http://dx.doi.org/10.1039/d0nh00550a.
    Acesso aberto • 10.1039/d0nh00550a
  5. Patricia R. Pitrez; Luís Estronca; Luís Miguel Monteiro; Guillem Colell; Helena Vazão; Deolinda Santinha; Karim Harhouri; et al. "Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13". Nature Communications (2020): https://doi.org/10.1038/s41467-020-17901-2.
    10.1038/s41467-020-17901-2
  6. S. Rosa; C. Praça; P. R. Pitrez; P. José Gouveia; X. L. Aranguren; L. Ricotti; L. Silva Ferreira. "Functional characterization of iPSC-derived arterial- and venous-like endothelial cells". Scientific Reports 9 1 (2019): https://doi.org/10.1038/s41598-019-40417-9.
    10.1038/s41598-019-40417-9
  7. Rosa, Susana; Pitrez, Patrícia; Fernandes, Hugo; Ferreira, Lino. "A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity". Current Protocols in Stem Cell Biology 50 1 (2019): http://dx.doi.org/10.1002/cpsc.93.
    10.1002/cpsc.93
  8. Pitrez, Patricia R.; Estronca, Luís; Vazão, Helena; Egesipe, Anne-Laure; Le Corf, Amélie; Navarro, Claire; Lévy, Nicolas; et al. "Substrate Topography Modulates Cell Aging on a Progeria Cell Model". ACS Biomaterials Science & Engineering (2018): http://dx.doi.org/10.1021/acsbiomaterials.8b00224.
    10.1021/acsbiomaterials.8b00224
  9. Vazão, Helena; Rosa, Susana; Barata, Tânia; Costa, Ricardo; Pitrez, Patrícia R.; Honório, Inês; de Vries, Margreet R.; et al. "High-throughput identification of small molecules that affect human embryonic vascular development". Proceedings of the National Academy of Sciences 114 15 (2017): E3022-E3031. http://dx.doi.org/10.1073/pnas.1617451114.
    10.1073/pnas.1617451114
  10. Ribas, João; Zhang, Yu Shrike; Pitrez, Patrícia R.; Leijten, Jeroen; Miscuglio, Mario; Rouwkema, Jeroen; Dokmeci, Mehmet Remzi; et al. "Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model". Small 13 15 (2017): 1603737. http://dx.doi.org/10.1002/smll.201603737.
    10.1002/smll.201603737
  11. Lo Cicero, Alessandra; Jaskowiak, Anne-Laure; Egesipe, Anne-Laure; Tournois, Johana; Brinon, Benjamin; Pitrez, Patricia R.; Ferreira, Lino; et al. "A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep34798.
    10.1038/srep34798
  12. Pitrez, P.R.; Rosa, S.C.; Praça, C.; Ferreira, L.. "Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome". Biochemical and Biophysical Research Communications 473 3 (2016): 710-718. http://dx.doi.org/10.1016/j.bbrc.2015.10.014.
    10.1016/j.bbrc.2015.10.014
  13. Blondel, S; Egesipe, A-L; Picardi, P; Jaskowiak, A-L; Notarnicola, M; Ragot, J; Tournois, J; et al. "Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation". Cell Death & Disease 7 2 (2016): e2105-e2105. http://dx.doi.org/10.1038/cddis.2015.374.
    10.1038/cddis.2015.374
Capítulo de livro
  1. Pitrez, Patrícia R.; Aires, Helena R.; Tomé, Inês; Ferreira, Rita Sá; Ferreira, Lino. "Physiological and Pathological Vascular Aging". In Biophysical Regulation of Vascular Differentiation and Assembly, 51-72. Springer International Publishing, 2018.
    10.1007/978-3-319-99319-5_3
Poster em conferência
  1. H.R. Aires; Pitrez, Patricia R.; Francisco, Vitor; Ferreira, Lino. "A Nanoparticle-based Innovative Senotherapy". Trabalho apresentado em European Tissue Repair Society (ETRS) and Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC) Joint Meeting, 2023.
  2. Tomé, Inês; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Suana Rosa; Pitrez, Patricia R.; Gracia-Sancho, Jordi; Diana Jurk; Francisco, Vitor; Ferreira, Lino. "Targeting the senescence program in the blood brain barrier with senotherapeutic nanoparticles". Trabalho apresentado em 33rd Annual Conference of the European Society for Biomaterials, 2023.
  3. Aires, Helena R.; Pitrez, Patricia R.; Francisco, Vitor; Ferreira, Lino. Autor correspondente: Ferreira, Lino. "Senolysis as a therapeutic approach for cardiovascular aging". Trabalho apresentado em Ageing With]Out[Borders in Faro, Portugal., 2022.
  4. Luís M. Monteiro; Pitrez, Patricia R.; Correia-Santos, Simão; Ferreira, Lino. Autor correspondente: Ferreira, Lino. "Modeling of ageing in human cardiomyocytes derived from induced pluripotent stem cells.". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2022.
  5. Correia-Santos, Simão; Pitrez, Patricia R.; Ferreira, Lino. Autor correspondente: Ferreira, Lino. "Progerin in the heart - the untold cardiomyocyte history"". Trabalho apresentado em Multidisciplinary Institute of Ageing Spring School, 2022.
  6. Monteiro, Luís; Pitrez, Patricia R.; Correia-Santos, Simão; Nicola Dark; Deolinda Santinha; Xavier, Nissan; Sardão, Vilma; et al. Autor correspondente: Monteiro, Luís. "Disease modeling and drug screening on cardiomyocytes derived from Hutchinson-Gilford Progeria Syndrome- induced pluripotent stem cells". Trabalho apresentado em The Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2022.
  7. Sá Ferreira, Rita; Pitrez, Patricia R.; Rebelo, Catarina; Aires, Helena R.; Alessandro Ori; Passos, Joao; Ferreira, Lino. Autor correspondente: Ferreira, Lino. "Extracellular matrix as a trigger for cellular senescence". Trabalho apresentado em ResetAgeing Conference, Newcastle, UK., 2022.
  8. Sá Ferreira, Rita; Pitrez, Patricia R.; Ferreira, Lino. Autor correspondente: Ferreira, Lino. "Extracellular matrix of senescent cells: what should we expect?". Trabalho apresentado em 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society, 2021.
  9. Santos, Simão; Pitrez, Patricia R.; Ferreira, Lino. "Progerin heart expression in progeroid animals". Trabalho apresentado em Annual Scientific Meeting of the European Society for Clinical Investigation at Coimbra, Portugal., 2021.
  10. Helena R. Aires; Pitrez, Patricia R.; Lino Ferreira. "Senolytics: a therapeutic solution for vascular aging?". Trabalho apresentado em 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies. Faculty of Pharmacy of University of Lisbon, Lisboa, Portugal., 2019.
  11. Pitrez, Patricia R.; Luis Estronca; Helena Vazão; Anna-Laure Egesipe; Xavier Nissan; Lino Ferreira. "Micropatterned substrates to accelerate pathological smooth muscle cells aging". Trabalho apresentado em Ageing: models, mechanisms and therapies. Coimbra, Portugal., 2019.
  12. Helena R. Aires; Pitrez, Patricia R.; Lino Ferreira. "Senolitycs: a therapeutic solution for vascular aging?". Trabalho apresentado em 1st Conference on "Ageing: Models, mechanisms and therapies”, promoted under the project EraChair@UC, Faculty of Medicine, University of Coimbra. Coimbra. Portugal, 2019.
  13. Ana Cunha; Pitrez, Patricia R.; Ferreira, Lino. "An in vitro screening platform to identify compounds against vascular ageing". Trabalho apresentado em 1st Conference on "Ageing: Models, mechanisms and therapies, promoted under the project EraChair@UC, Faculty of Medicine, University of Coimbra. Coimbra. Portugal, 2019.
  14. Helena R. Aires; Pitrez, Patricia R.; Lino Ferreira. "Senolitycs: a therapeutic solution for vascular aging?". Trabalho apresentado em Annual Scientific Meeting of the European Society for Clinical Investigation at Coimbra, Portugal., 2019.
  15. Inês Tomé; Pitrez, Patricia R.; Glória Conceição; Francisco Nóvoa; Henrique Girão; Inês Fralcão-Pires; Diana Nascimento; Perpétua Pinto-do-Ó; Adelino Leite-Moreira. "Endothelial Dysfunction in the context of HFpEF". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation at Coimbra, Portugal., 2019.
  16. Inês Tomé; Pitrez, Patricia R.; Ferreira, Lino. "Endothelial Dysfunction in the context of HFpEF". Trabalho apresentado em 11th International Meeting ofthe Portuguese Society for Stem Cells and Cell Therapies. Faculty of Pharmacyof University of Lisbon, Lisboa, Portugal., 2019.
  17. Inês Tomé; Pitrez, Patricia R.; Ferreira, Lino. "Endothelial Dysfunction in the context of HFpEF". Trabalho apresentado em Ageing: models, mechanismsand therapies. Coimbra, Portugal., 2019.
  18. Pitrez, Patricia R.; Helena Vazão; Luis Estronca; Anne-Laure Egesipe; Claire Navarro; Annachiara De Sandre-Giovannoli; Xavier Nissan; Lino Ferreira. "The susceptibility of progeria-smooth muscle cells to arterial flow is mediated by an enzyme". Trabalho apresentado em IUBMB Focused Meeting on Molecular aspects of aging and longevity. Athens, Greece, 2017.
  19. Pitrez, Patricia R.; Helena Vazão; Luis Estronca; Anne-Laure Egesipe; Claire Navarro; Annachiara De Sandre-Giovannoli; Xavier Nissan; Lino Ferreira. "An ageing disease model from progeria induced pluripotent stem cells identify an anti-ageing compound". Trabalho apresentado em TERMIS. Davos, Switzerland, 2017.
  20. Pitrez, Patricia R.; Luis Estronca; Helena Vazão; Anna-Laure Egesipe; Xavier Nissan; Lino Ferreira. "Micropatterned substrates to accelerate pathological smooth muscle cells aging". Trabalho apresentado em MIT Portugal Annual Conference. Braga. Portugal, 2016.
  21. Pitrez, Patricia R.; Luis Estronca; Helena Vazão; Anna-Laure Egesipe; Xavier Nissan; Lino Ferreira. "Micropatterned substrates to accelerate pathological smooth muscle cells aging". Trabalho apresentado em The Progeria Research Foundation 8th International Scientific Workshop. Cambridge, MA USA., 2016.
  22. Helena Vazão; Tânia Barata; Susana Rosa; S. Pontes-Quero; Inês Honório; Pitrez, Patricia R.; N. Mercander; et al. "High-throughput identification of small molecules that affect human embryonic vascular development". Trabalho apresentado em 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies. Oeiras, Portugal, 2015.
Resumo em conferência
  1. Luis Monteiro; Pitrez, Patricia R.; N Dark; Deolinda Santinha; Xavier, Nissan; Sardão, Vilma; Francisco, Vitor; et al. "Modeling and drug screening on human cardiomyocytes derived from hutchinson-gilford progeria syndrome induced pluripotent stem cells". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Bari, 2022.
    Publicado
Tese / Dissertação
  1. Pereira, Patrícia Raquel Pinheiro Pitrez; Ferreira, Lino Augusto; Rocha, Isabel Cristina Santos. "Bioengineering Platforms to Modulate the Activity of Smooth Muscle Cells Derived from Progeria-Induced Pluripotent Stem Cells". Doutoramento, 2016.
  2. Pitrez, Patricia R.. "Monitoring of Glucose and Lactate Concentrations in Mammalian Cultivations using Mid-IR Spectroscopy". Mestrado, Universidade do Minho, 2009.

Propriedade Intelectual

Patente
  1. Pitrez, Patricia R.; Helena Vazão; Ferreira, Lino. 2016. "Treatment of Hutchinson-Gilford Progeria Syndrome and diseases related to vascular ageing".

Outros

Outra produção
  1. Differentiation of human induced-pluripotent stem cells into smooth muscle cells. 2021. Patricia R. Pitrez; Lino Ferreira. https://doi.org/10.21203/rs.3.pex-964/v1.
    10.21203/rs.3.pex-964/v1
  2. Organ-On-A-Chip: Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. Back Cover - Small 15/2017. 2017. João Ribas; Yu Shrike Zhang; Pitrez, Patricia R.; Jeroen Leijten; Mario Miscuglio; Jeroen Rouwkema; Mehmet Remzi Dokmeci; et al.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/12 Extracellular matrix as a trigger for a cellular senescence program Ageing With]Out[Borders
(Faro, Portugal)
2022/12 A model of aged cardiomyocytes derived from induced pluripotent stem cells Ageing With]Out[Borders in Faro, Portugal.
(Faro, Portugal)
2022/09 ABT263 - alleviating the Hutchinson Gilford Progeria Syndrome senescent phenotype ResetAgeing Conference, Newcastle, UK.
(Newcastle, Reino Unido)
2022/06 Subacute ABT263 treatment as a possible therapeutic for HGPS. 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Bari, Itália)
2022/03 Modeling Progeria Syndrome On Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies
2022/03 Induced pluripotent stem cell-derived vascular networks to screen nano-bio interactions 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies
2022 A cellular senescence program induced by extracellular matrix 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Bari, Itália)
2021/11/16 Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13 TERMIS - 6th World Congress 2021 - Online Event
TERMIS
2021/11/16 Induced pluripotent stem cell-derived vascular networks to screen nano-bio interactions 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society
TERMIS
2021/09/06 Engineered formulations for gene editing 31st conference of the European Society of Biomaterials, satellite event: NANOSTEM, Nanoparticles for modulation of gene expression.
European Society of Biomaterials
2021/06/11 The vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13 55th Annual Scientific Meeting - ESCI Virtual 2021
European Society for Clinical Investigation
2021/06/10 Extracellular matrix of senescent cells: what should we expect? 55th Annual Scientific Meeting
European Society for Clinical Investigation
2021 Development of Cell Platforms derived from induced pluripotent stem cells for screening toxicity of nanomaterials 55th Annual Scientific Meeting - ESCI Virtual 2021
ESCI
2019/11 Endothelial Dysfunction in the context of HFpEF SPCCTV - Surgery without borders
Sociedade Portuguesa de Cirurgia Cardiotorácica e Vascular (Albufeira, Portugal)
2019/10 Generation and characterization of cardiomyocytes derived from a human pluripotent stem cell model of Hutchinson-Gilford progeria syndrome 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies. Faculty of Pharmacy of University of Lisbon, Lisboa, Portugal.
Portuguese Society for Stem Cells and Cell Therapies
2019/09 Vulnerability of Progeroid Smooth Muscle Cells to biomechanical forces is mediated by an enzyme 9th UK Nuclear Envelope and Chromatin Organization Meeting and 3rd International Meeting on Laminopathies.
(London, Reino Unido)
2017/10 An aging disease model from a monoculture of progeroid smooth muscle cells generated from iPSCs identify an anti-aging compound 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies.
University of Covilhã (Covilhã, Portugal)
2016/12 The vulnerability of smooth muscle cells derived from Hutchinson-Gilford Progeria Syndrome (HGPS) iPSCs to arterial flow shear stress is mediated by metalloproteases. XIII CNC Annual Meeting
Universty of Coimbra (Coimbra, Portugal)
2016/09 The susceptibility of progeria-smooth muscle cells to arterial flow is mediated by an enzyme 1st Symposium on Aging Research @CNC
University of Coimbra (Coimbra, Portugal)
2016/07 Bioengineering Platforms to Modulate the Activity of Smooth Muscle Cells Derived from Progeria-Induced Pluripotent Stem Cells German-Portuguese Student Workshop within the DAAD-Programme “Dialogue with Institutions of Higher Education in Southern Europe”
Biomaterials and Stem Cell Research (Cantanhede, Portugal)
2016/06 Micropatterned substrates to accelerate pathological smooth muscle cells aging 5th International Iberian Biophysics Congress
University of Porto (Porto, Portugal)
2015/12 The vulnerability of smooth muscle cells derived from Hutchinson-Gilford Progeria Syndrome (HGPS) iPSCs to arterial flow shear stress is mediated by metalloproteases XIII Annual Center for Neurosciences and Cell Biology Annual Meeting
University of Coimbra (Coimbra, Portugal)
2015/10 The vulnerability of smooth muscle cells derived from Hutchinson-Gilford Progeria Syndrome (HGPS) iPSCs to arterial flow shear stress is mediated by metalloproteases. 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies.
(Oeiras, Portugal)
2015/01 Dissecting the vulnerability of HGPS-SMCs to arterial flow First French-Italian meeting on laminopathies and other nuclear envelope-related diseases
(Marseille, França)
2014/06 Assessment of embryonic vascular toxicity by pluripotent stem cell-derived arterial endothelial cells on a microfluidic system
Tissue Engineering International & Regenerative Medicine Society (Genova, Itália)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023 - Atual High-throughput screening of microRNA-based senotherapeutics
Orientador
Universidade de Coimbra, Portugal
2022/02 - Atual Initialization to cell culture
Orientador
 Biologia (Iniciação científica)
Universidade de Coimbra, Portugal
2022 - Atual Novel molecular targets and therapeutic strategies for Hutchinson-Gilford Progeria Syndrome's cardiovascular system
Orientador
Universidade de Coimbra, Portugal
2021/10 - Atual Nanoformulations to fight vascular aging
Orientador
 Engenharia Biomédica (Mestrado)
Universidade de Coimbra, Portugal
2021 - Atual Initialization to cell culture
Orientador
 Engenharia Biomédica (Iniciação científica)
Universidade de Coimbra, Portugal
2020/01/01 - Atual Nanoparticles to target senescent vascular cells
Orientador
Universidade de Coimbra, Portugal
2018/01/01 - Atual Tissue Engineering-based novel therapies and in vitro models for heart disease.
Orientador
Universidade de Coimbra, Portugal
2017/01 - 2022 Vascular cell senescence: triggers and therapeutic strategies
Coorientador
 MIT Portugal Program - Bioengineering Systems (Doutoramento)
Universidade Nova de Lisboa, Portugal
2020/02 - 2020/03 Identification and characterization of vascular senescent cells
Orientador
Universidade de Coimbra, Portugal
2018/05 - 2019/09 Targeting Senescent Endothelial Cells
Orientador
 Engenharia Biomédica (Mestrado)
Universidade de Coimbra, Portugal
2017/05 - 2018/10 High-throughput Identification of Polymeric Compounds That Affect Human Vascular Cell Senescence
Orientador
 Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2017/05 - 2017/06 Initialization to cell culture
Orientador
Universidade de Coimbra, Portugal
2017/04 - 2017/05 Initialization to vascular cell senescence
Orientador
Universidade de Coimbra, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/09 - Atual Co-chair of a ESB2023 Symposium entitled Extracellular Vesicles Bioengineering for Cardiovascular Repair. As one of the prime biomaterials events of the year, the 33rd Annual Conference of the European Society for Biomaterials, ESB2023, goal is to promote interactions and collaborations between researchers, educators, clinicians and industry representatives who are interested in biomaterials. (2023/09)
Simpósio
 European Society for Biomaterials, Suiça
2021/06/11 - 2021/06/11 Chair and Co-organizer of the 1st RESETageing Conference, Online, June 11th 2021. The conference had the attendance of more than 200 indiduals from academia and research institutions. The conference was divided in several sessions including: Cell Senescnece; Omics of Ageing; Cardiovascular Ageing. (2021/06/11 - 2021/06/11)
Conferência (Coorganizador)
 Universidade de Coimbra, Portugal
2019/06/28 - 2019/06/29 Chair and Co-organizer of the International conference on Ageing: models, mechanisms and therapies, Faculty of Medicine, University of Coimbra, Polo III, June 28th-29th 2019. The conference had the attendance of 223 indiduals from academia and research institutions. The conference was divided in several sessions including: Ageing and extracellular matrix, Anti-ageing therapies, Ageing mechanisms, Cardiovascular ageing and Acelerated ageing: models, mechanisms and therapies. (2019/06/28 - 2019/06/29)
Conferência (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal
2018/06/27 - 2018/06/27 Workshop on Ageing: models and therapies, Faculty of Medicine, University of Coimbra, Polo III, June 27th, 2018. The meeting had the contribution of Alessandro Ori (Leibniz Institute of Ageing, Germany), Thomas von Zglinicki (University of Newcastle, UK), Bruno Jesus (IMM and University of Aveiro), Manuel Santos (University of Aveiro), Claudia Cavadas (University of Coimbra), Rodrigo Cunha (University of Coimbra) and João Malva (University of Coimbra). Approximately 75 individuals from academia and research institutions attended this meeting. (2018/06/27 - 2018/06/27)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal
2016/07/07 - 2016/07/08 German-Portuguese student Workshop on “Translation in Biomaterials and Stem Cell Research”, Biocant, Cantanhede, Portugal, July 7-8 2016. The event was organized in collaboration with Dr. Tilo Pompe from the University of Leipzig, Germany, and funded by the DAAD program “Dialogue with Institutions of Higher Education in Southern Europe”. The Workshop had the contribution of Dror Seliktar (Technion University, Israel). (2016/07/07 - 2016/07/08)
Oficina (workshop) (Membro da Comissão Organizadora)
 Biocant Associação de Transferência de Tecnologia, Portugal
2016/06/27 - 2016/06/27 Stem cell workshop: from basic research to clinical applications, Centro Hospitalar da Universidade de Coimbra, Portugal, June 27th 2016. The event was organized by Lino Ferreira and Artur Paiva. Approximately 75 individuals from academia, hospital and research institutions attended this meeting. (2016/06/27 - 2016/06/27)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal
2014/03/24 - 2014/03/24 Workshop on Stem cells: from basic research to therapeutic applications, Centro do Sangue e Transplantação de Coimbra, Coimbra, Portugal, March 24th, 2014. The event was organized by Lino Ferreira and Artur Paiva. The workshop had the contribution of Francisco Santos (Cell2B), Natália António (MD, Centro Hospitalar da Universidade de Coimbra), Claudia Torres (Hospital Geral de Santo António), Henrique Veiga Fernandes (IMM, Lisboa), Claudia Lobato (Instituto Superior Técnico, Lisboa), Salomé Maia (Instituto Portugues do Sangue e da Transplantação)... (2014/03/24 - 2014/03/24)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal
2013/12 - 2013/12 German-Portuguese student Workshop on “Matrix Engineering meets Stem Cell Therapy”, Biocant, Cantanhede, Portugal, December 2013. The event was organized in collaboration with Dr. Tilo Pompe from the University of Leipzig, Germany, and funded by the DAAD program “Dialogue with Institutions of Higher Education in Southern Europe”. The Workshop had the contribution of Andreia Bernardo, University of Cambridge, UK, and Andras Dinnyes, Biotalentum, Hungary. (2013/12 - 2013/12)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal
2013/07/19 - 2013/07/19 First International Conference on Stem Cells for Drug Screening and Regenerative Medicine, Biocant, Cantanhede, Portugal, July 19th, 2013. The meeting covered aspects regarding: (i) stem cell bioengineering, (ii) translation of stem cell-based technologies, and (iii) induced pluripotent stem cells- opportunities for disease modeling and drug discovery. Approximately 150 individuals from academia, hospitals and research institutions attended this meeting. (2013/07/19 - 2013/07/19)
Conferência (Membro da Comissão Organizadora)
 Biocant Associação de Transferência de Tecnologia, Portugal
2011/04/28 - 2011/04/29 6th Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies, Cantanhede, Portugal, April 28-29, 2011. The meeting congress was divided in 6 sessions covering aspects related to cancer stem cells, pluripotent stem cells, neural stem cells, neural tissue engineering, stem cell bioengineering and regenerative medicine. Approximately 180 individuals from academia, hospitals and research institutions attended this meeting. (2011)
Encontro (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/12 - Atual Ageing With]Out[Borders
2022/09 - Atual ResetAgeing Conference
Conferência
2022/06 - Atual 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) at Bari, Italy.
Encontro
2022 - Atual Participation in European Researcher´s Night. Coimbra. Portugal
Outro
2021/11 - Atual 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS). Virtual
2021 - Atual Participation in European Researcher´s Night. Coimbra. Portugal
Outro
2019 - Atual 11th International Meeting ofthe Portuguese Society for Stem Cells and Cell Therapies. Faculty of Pharmacyof University of Lisbon, Lisboa, Portugal., 2019.
Encontro
2019 - Atual 1st Conference on "Ageing: models, mechanisms and therapies". Coimbra, Portugal., 2019.
Conferência
2019 - Atual “Identificação de novos fármacos”. Diálogos com Cientistas. Instituto de Educação e Cidadania (Mamarrosa, Portugal).
Outro
2018 - Atual “Células Estaminais: O que são? Onde Estão no Nosso Corpo?” Escola Secundária Adolfo Portela (Águeda, Portugal).
Outro
2018 - Atual “Células estaminais como modelo de envelhecimento vascular”. IX Jornadas de Ciências da Saúde. Instituto Universitário Egas Moniz. (Monte da Caparica, Portugal).
Outro
2017 - Atual TERMIS. Davos, Switzerland, 2017
Conferência
2017 - Atual 10th International Meeting of the Portuguese Society for Stem Cells andCell Therapies.University of Covilhã, Portugal. 2017
Encontro
2017 - Atual The III Semana da BioengenhariaInstituto Superior Técnico (SBE IST). Lisbon, Portugal. 2017
Encontro
2017 - Atual “Identificação de novos fármacos”. Diálogos de Verão com Cientistas. Instituto de Educação e Cidadania (Mamarrosa, Portugal).
Outro
2017 - Atual Organization and Participation in “Festival de Ciência de Oliveira do Bairro” FeCiOB. Oliveira do Bairro. Portugal
Outro
2017 - Atual Organization and Participation Participated in European Researcher´s Night. Coimbra. Portugal
Outro
2016 - Atual MIT Portugal AnnualConference. Braga. Portugal, 2016.
Conferência
2016 - Atual The Progeria ResearchFoundation 8th International Scientific Workshop. Cambridge, MA USA., 2016
Oficina (workshop)
2016 - Atual XIII CNC Annual Meeting. Universty of Coimbra, Portugal. 2016
Encontro
2016 - Atual 1st Symposium on Aging Research@CNC University of Coimbra, Portugal. 2016
Simpósio
2016 - Atual German-Portuguese Student Workshop within the DAAD-Programme “Dialogue with institutions of Higher Education in southern Europe” Biomaterials and Stem Cell Research, Cantanhede, Portugal. 2016
Oficina (workshop)
2016 - Atual 5th International Iberian Biophysics Congress University of Porto, Porto, Portugal. 2016
Congresso
2015 - Atual 9th International Meeting of the Portuguese Society for StemCells and Cell Therapies. Oeiras, Portugal, 2015
Encontro
2015 - Atual XIII Annual Center for Neurosciences and Cell Biology Annual Meeting University of Coimbra, Coimbra, Portugal. 2015
Encontro
2015 - Atual First French-Italian meeting on laminopathies and other nuclear envelope-related diseases, Marseille, France. 2015
Encontro
2021/06/07 - 2021/06/10 RESETageing Training School. Gene and proteomic analyses.
Oficina (workshop)
 RESETageing Training School
Universidade de Coimbra, Portugal
2021/06/07 - 2021/06/10 RESETageing Training School - Gene and Proteomic Analyses
Oficina (workshop)
 RESETageing Training School
Universidade de Coimbra, Portugal
2021/06/09 - 2021/06/09 55th Annual Scientific Meeting - ESCI Virtual 2021
Encontro
 55th Annual Scientific Meeting - ESCI Virtual 2021
2019/09/02 - 2019/09/05 9th UK Nuclear Envelope and Chromatin Organization Meeting 3rd International Meeting on Laminopathies. 2nd – 5th September 2019, London, UK
Conferência
2017/10/19 - 2017/10/20 IUBMB Focused Meeting on "Molecular aspects of aging and longevity". Athens. Greece. 2017
Encontro
2017/01/17 - 2017/01/19 MouseAGE training school Grant: Introduction to Mathematical and Computational Modelling: from mouse to computer and back. 2017
Oficina (workshop)
Technische Universiteit Eindhoven Faculteit Biomedische Technologie, Países Baixos

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/01 Empowering the therapeutical potential of clinically expired platelet concentrates: a new source of extracellular vesicles
Arguente principal
 Ana Eduarda Lopes Meliciano (Mestrado)
Universidade Nova de Lisboa Departamento de Química, Portugal
2021/12 Targeting the endocrine system to slow down aging in Hutchinson-Gilford Progeria Syndrome
Arguente principal
 Ana Carolina Martins Real (Mestrado)
Universidade de Coimbra, Portugal
2021/11 The impact of the diet in adult C57BI/6J mice pancreas function with age
Arguente principal
 Ana Teresa Maduro (Mestrado)
Universidade de Coimbra, Portugal
2019/12 Enginheering Extracellular Matrix-derived Constructs for Human Cardiac Tissue Models
Arguente principal
 Miguel Tenreiro (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2022/08 - 2023/02 Scientific Reports

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022 - Atual Lecturer - Ph.D. Advanced course in Experimental Biology and Biomedicine. Advanced Therapies Module - Disease modeling with human pluripotent stem cells. University of Coimbra. Portugal (Doutoramento)
2022 - Atual Lecturer - Ph.D. Program in Pharmacy - Course on Stem Cell Technologies - Modeling diseases using Stem Cells. - Faculty of Pharmacy at the University of Lisbon, and Champalimaud Foundation - Lisbon. Portugal (Doutoramento)
2019/03 - Atual Lecturer - Diálogos com Cientistas - Instituto de Educação e Cidadania, Identificação de novos fármacos, Mamarrosa, Portugal (Ensino secundário)
2018/12 - Atual Lecturer - Escola Secundária Adolfo Portela - Células Estaminais: O que são? Onde Estão no Nosso Corpo? - Águeda, Portugal (Ensino secundário)
2018/04 - Atual Lecturer - IX Jornadas de Ciências da Saúde - Instituto Universitário Egas Moniz. - Células estaminais como modelo de envelhecimento vascular. Monte da Caparica, Portugal (Mestrado)
2018/03 - Atual Lecturer - Ph.D. BEB Advanced Course. Ageing: from cellular processes to the organism. - Pathological vascular aging: modeling and therapies - University of Coimbra; Coimbra, Portugal (Doutoramento)
2017/07 - Atual Lecturer - Diálogos de Verão com Cientistas - Instituto de Educação e Cidadania - Identificação de novos fármacos. - Mamarrosa, Portugal (Ensino secundário)
2017/03 - Atual Lecturer - The III Semana da Bioengenharia - Instituto Superior Técnico - An ageing disease model from Progeria induced pluripotent stem cells identify an anti-ageing compound. - SBE IST, Lisbon, Portugal (Mestrado)
2016/06 - Atual Lecturer - Ph.D. in Experimental Biology and Biomedicine. Advanced Therapies Module - Dissecting the vulnerability of Progeria-SMCs to arterial flow - Coimbra. Portugal (Doutoramento)
2022 - 2022 Invited professor in the Master's program of Biomedical Engineering - Course Regenerative Medicine. University of Coimbra. Portugal Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2021 - 2021 Invited professor in the Master's program of Biomedical Engineering - Course Regenerative Medicine. University of Coimbra. Portugal Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2020 - 2020 Invited professor in the Master's program of Biomedical Engineering - Course Regenerative Medicine. University of Coimbra. Portugal Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09/01 - 2019/11/30 Invited professor in the Master's program of Biomedical Engineering - Course Regenerative Medicine. University of Coimbra. Portugal Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09/01 - 2018/11/30 Invited professor in the Master's program of Biomedical Engineering - Course Regenerative Medicine. University of Coimbra. Portugal Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2020/08/19 More than 45 newspaper publish and interview regarding the work published in Nat Comms Público, RTP, Porto Canal, Sapo, Observador, TVI24,...

Entrevista / Programa (rádio / tv)

Programa Tema
2020/08/19 - Atual Rádio Obervador - E=MC2
2020/08/17 - Atual National TV - TVI24 Noite 24
2017/03/15 - Atual 90 Segundos de Ciência PROGERIA COMO MODELO PARA DESCOBRIR NOVAS TERAPIAS CONTRA DOENÇAS CARDIOVASCULARES

Tutoria

Tópico Nome do aluno
2020/09/01 - Atual MSc Thesis - Heart and ageing - lessons from progeria syndrome Simão Correia Santos
2020/01/01 - Atual Ph.D. Thesis - A senolytic delivery system able to cross the blood brain barrier Inês Tomé
2019/01/01 - Atual Ph.D. Thesis - Gene editing strategies for aged cells Angela Barrera
2021/01 - 2021 MSc Fellow - Caracterization of endothelial senescence miRNA João Novo
2019/12 - 2020/07 MSc Fellow - The role of the ECM on senescence induction in vascular cells André Barbosa
2019/02 - 2020 MSc fellow - Identification of endothelial senescence miRNA Marta Barão
2017/05 - 2018/09 MSc Thesis - Breaking the barriers of HFpEF: a new “blood vessel on a chip model" Inês Tomé
2016/10/10 - 2017/01/15 MSc Fellow - Evaluate the vascular toxicity of nanoparticles in vascular cells Alexandrina Amorim
Distinções

Prémio

2022 Poster Prize at ResetAgeing Conference
2022 Crioestaminal & SPCE-TC Regenerative Medicine Research Award.
Crioestaminal, Portugal
2021 Poster Prize at ESCI 55TH Virtual ASM
European Society for Clinical Investigation, Países Baixos
2019 2020 Research Fellowship from the CEU-Canon Foundation in Europe for staying 6 months in Japan - May-October 2020
Canon Foundation in Europe, Países Baixos
2010 PhD Scholarship. FCT (Fundação para a Ciência e Tecnologia) (2010) SFRH/BD/71042/2010.
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2019 COST ITC grant for Early Career Investigators to participate in 9th UK Nuclear Envelope and Chromatin Organization Meeting 3rd International Meeting on Laminopathies.
2017 MouseAGE training school Grant: Introduction to Mathematical and Computational Modelling: from mouse to computer and back. 17th - 19th January 2017. Eindhoven University of Technology, Eindhoven, the Netherlands
2017 MouseAGE Grant for IUBMB Focused Meeting on «Molecular aspects of aging and longevity» 19th – 20th October 2017, Athens, Greece