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Marta Costa is an Assistant Researcher, at the Life and Health Sciences Research Institute (ICVS) - University of Minho (UM), focusing on the development of innovative cancer therapeutics. Marta is also co-founder of the spin-off Karion Therapeutics, where she serves as CEO. With degree in Applied Chemistry (UM, 2006) and a PhD in Sciences - Organic Chemistry (UM, 2011), Marta's journey includes roles as a Medicinal Chemist at the pharmaceutical Bial, postdoctoral positions at the Chemistry Department - UM (2012-2014) and international experience at Leiden University Medical Center (2012). Joining the ICVS in 2015 as a post-doctoral fellow, Marta now displays multidisciplinary expertise as an Assistant Researcher. Her focus centers on pioneering therapies, particularly small molecule-based organic compounds, targeting aggressive cancers like triple negative breast cancer and renal cell carcinoma. Noteworthy contributions comprise international publications, book chapters, and two patents (WO/2020/261242 and WO/2021/191882). She actively involved in the supervision of numerous students across academic levels, supervising research projects, and contributing to teaching and science dissemination activities. Marta has earned recognition with multiple national and international awards. Notably, her work was honored with the Born from Knowledge award (BfK, 2023), Arqus International Innovators Award (2023), Innovation Award Bluepharma (2022), SpinUM award (2022), UI-CAN award (2022), LPCC-NRN research grants (2019, 2022), FEDER project grant (2020). Driven to enhance cancer patient survival and their quality of life, Marta is a medical chemist dedicated to advancing innovative cancer therapeutics.
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Identificação

Identificação pessoal

Nome completo
Marta Sílvia Freitas da Costa
Data de nascimento
1981/06/13
Género
Feminino

Nomes de citação

  • Costa, Marta

Identificadores de autor

Ciência ID
9A13-1430-85B1
ORCID iD
0000-0002-4287-0659
Google Scholar ID
https://scholar.google.pt/citations?user=hBFNCTIAAAAJ&hl=pt-PT
Researcher Id
B-7247-2014
Scopus Author Id
56352738800

Endereços de correio eletrónico

  • martafcosta@med.uminho.pt (Profissional)
  • martasilviacosta@gmail.com (Pessoal)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde
  • Ciências Exatas - Química - Química Orgânica
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1)
Formação
Grau Classificação
2023/12/04 - 2023/12/12
Concluído
 Women InnoVenture: Empowering Women in Healthtech (Outros)
EIT Health, Alemanha
2023/02/01 - 2023/03/01
Concluído
 How to build empathy in research: techniques to generate empathy in qualitative research (Outros)
Universidade do Minho Escola de Medicina, Portugal
2023/01/01 - 2023/02/28
Concluído
 Business Development for Researchers + Lean Startup Principles (Outros)
Universidade do Minho Escola de Medicina, Portugal
2022 - 2022
Concluído
 Business Laboratory (Laboratório de Empresas) (Outros)
TechMinho, Portugal
2021/04 - 2021/07
Concluído
 HiTech (Outros)
HiSeedTech, Portugal
2021 - 2021
Concluído
 Orhpeus Conference (Outros)
Universidade do Minho, Portugal
2020 - 2020
Concluído
 TMex - Translational Medicine explained course (Outros)
European infrastructure for translational medicine (EATRIS), Países Baixos
2019 - 2019
Concluído
 Transversal Skills Workshops series - 2019/2020: Balance of skills and self-knowledge (Outros)
Universidade do Minho Escola de Medicina, Portugal
2019 - 2019
Concluído
 Transversal Skills Workshops series - 2019/2020: Creativity (Outros)
Universidade do Minho Escola de Medicina, Portugal
2014 - 2014
Concluído
 Cell culture and safety course (Outros)
Universidade do Minho Escola de Medicina, Portugal
2012 - 2012
Concluído
 Internship at the Leiden University Medical Center (Outros)
Leiden University Medical Center (LUMC), Países Baixos
2007/05/01 - 2011/04/29
Concluído
 PhD in Sciences - Chemistry (Doutoramento)
Especialização em Organic synthesis
Universidade do Minho, Portugal
"Synthesis of chromene derivatives for the screening as antipsychotic agents" (TESE/DISSERTAÇÃO)
 Approved
2010 - 2010
Concluído
 9th Swiss Course on Medicinal Chemistry (Outros)
Swiss division of Medicinal Chemistry from the Swiss Society of Chemistry, Suiça
2009 - 2009
Concluído
 Fundamentals in Neuroscience (Outros)
Universidade do Minho Escola de Medicina, Portugal
2002/09/01 - 2006/10/31
Concluído
 Degree in Applied Chemistry, Textile Materials Quality (Licenciatura)
Universidade do Minho, Portugal
"Studies on the reactivity of salicylaldehydes with activated methylene compounds" (TESE/DISSERTAÇÃO)
 17
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/20 - Atual Investigador Contratado (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
2015/01/01 - 2019/02/19 Pós-doutorado (Investigação) Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
2012/01/01 - 2014/12/31 Pós-doutorado (Investigação) Universidade do Minho Centro de Química, Portugal
Universidade do Minho, Portugal
(...)
2011/05/01 - 2011/12/31 Investigador Contratado (Investigação) Bial, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/09/01 - 2014/07/31 Professor Auxiliar Convidado (Docente Universitário) Universidade do Minho, Portugal
Universidade do Minho - Escola de Ciências, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/08/16 - Atual Co-Founder and Chief Executive Officer (CEO) Karion Therapeutics, Lda., Portugal
Universidade do Minho Escola de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2022/09/01 - 2026/08/31 Novel KDM4C inhibitors for the treatment of triple negative breast cancer: rational design, synthesis and biological validation
2022.11395.BD
Orientador
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a tecnologia (FCT)
Em curso
2022/09/01 - 2026/08/31 Novel chromene-based compounds as candidates for bladder cancer therapeutics
2022.11018.BD
Orientador
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a tecnologia (FCT)
Em curso
2022/09/01 - 2026/08/31 Exploitation of a novel drug candidate for renal cell carcinoma therapy
2022.10233.BD
Orientador
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a tecnologia (FCT)
Em curso
2021/01/01 - 2025/12/31 New imidazole and chromene-based scaffolds for a multi-targeted approach on breast cancer therapy
2020.07919.BD
Orientador
Fundação para a Ciência e a tecnologia (FCT)
Em curso
2020/11/01 - 2024/10/31 Chromene-based molecules for triple negative breast cancer therapy: synthesis, nanoencapsulation and biological studies
2020.05982.BD
Orientador
Universidade do Minho Centro de Química, Portugal

Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
Fundação para a Ciência e a tecnologia (FCT)
Em curso
2021/06/01 - 2024/05/31 Real-time multi-photon microscopy for optical biopsy of colorectal tissues
PTDC/FIS-OTI/1259/2020
Investigador
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal

Universidade do Minho Centro de Sistemas Microeletromecânicos, Portugal

Universidade do Minho Centro de Física, Portugal
Fundação para a Ciência e a tecnologia (FCT)
Em curso
2022/04/01 - 2023/12/31 Establishment of a patient-derived xenograft CAM model for in vivo validation of the new anticancer drug candidate SM01
2CABraga/CRP/2022
Investigador responsável
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
 Clinical Academic Center of Braga (2CA-Braga)
Em curso
2022/07/01 - 2023/06/30 Novel drug candidate for cancer treatment
Bluepharma_2022
Investigador responsável
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
 Bluepharma
Em curso
2020/03/30 - 2023/05/31 SynCroTher - New chromene derivatives for cancer therapy
NORTE-01-0145-FEDER-046826
Investigador responsável
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
 European Regional Development Fund
Em curso
2022/01/01 - 2022/12/31 Innovative therapy for resistant renal cell carcinoma: molecular target validation
LPCC-NRN/2022
Orientador
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
Em curso
2022/04 - 2022/12 Karion Therapeutics - Unlocking new therapies
SpinUM_2022
Investigador responsável
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
 TecMinho Associação Universidade-Empresa para o Desenvolvimento
Em curso
2017/10/01 - 2022/04/20 Characterization of the anticancer efficacy and safety profiles of novel synthetic compounds
SFRH/BD/128850/2017
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho Escola de Medicina, Portugal
Fundação para a Ciência e a tecnologia (FCT)
Concluído
2019 - 2020 Chromene-based molecules as candidates for triple negative breast cancer treatment
LPCC/EMUM/2019
Orientador
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Norte

Universidade do Minho Escola de Medicina
Concluído
2015/01/31 - 2019/02/19 Chromene-based new drug candidates for cancer treatment: synthesis, structure-activity relationship and study of the molecular pathways for the most promising compounds
SFRH/BPD/79609/2011
Bolseiro de Pós-Doutoramento
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
 Fundação para a Ciência e a tecnologia (FCT)
Concluído
2012/01 - 2014/12 Synthesis of novel chromene-based compounds as antipsychotic agents
SFRH / BPD / 79609 / 2011
Bolseiro de Pós-Doutoramento
Universidade do Minho Centro de Química, Portugal
 Fundação para a Ciência e a tecnologia (FCT)
Concluído
2007/05/01 - 2011/04/29 Synthesis of chromene derivatives for the screening as antipsychotic agents
SFRH / BD / 31531 / 2006
Bolseiro de Doutoramento
Universidade do Minho Departamento de Química, Portugal
 Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2019/02/20 - 2025/02/19 Innovative cancer treatments
DL 57/2016/CP1377/CT0074
10.54499/DL57/2016/CP1377/CT0074
Investigador responsável
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2006/01/01 - 2006/12/31 Synthesis of nitrogen heterocycles with potential antioxidant activity
info:eu-repo/grantAgreement/FCT/POCI/45391/PT
Bolseiro de Iniciação Científica
Universidade do Minho Centro de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Ferreira, Débora; Cátia S. Pereira; Costa, Marta; Afonso, Julieta; Longatto, Adhemar; Baltazar, Fátima; Kalluri, Raghu; Moreira, João N.; Rodrigues, L. R.. "Exosome-mediated MEK1 silencing is a promising approach against triple negative breast cancer regression". 2022.
Artigo em revista
  1. Carvalho, Luísa; de Lima, Fábio Pedroso; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreiro, Sara; et al. "In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer". RSC Medicinal Chemistry (2024): http://dx.doi.org/10.1039/d3md00682d.
    Publicado • 10.1039/d3md00682d
  2. Ferreira, Débora; Santos-Pereira, Cátia; Costa, Marta; Afonso, Julieta; Yang, Sujuan; Hensel, Janine; McAndrews, Kathleen M.; et al. "Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells". Biomaterials Advances 154 (2023): 213643. http://dx.doi.org/10.1016/j.bioadv.2023.213643.
    Publicado • 10.1016/j.bioadv.2023.213643
  3. Bertão, Ana R.; Güney, Orhan; Costa, Marta; Fontão, Patrícia; Martinho, Olga; Costa, Susana P.G.; Fonseca, António M.; et al. "Sustainable fluorescent dye-faujasite zeolite systems as tools for cancer bioimaging". Chemical Engineering Journal 473 (2023): 145109. http://dx.doi.org/10.1016/j.cej.2023.145109.
    Publicado • 10.1016/j.cej.2023.145109
  4. Ana Silva; Mónica Costa Cerqueira; Beatriz Rosa; Catarina Sobral; Filipa Pinto-Ribeiro; Marta Freitas Costa; Fátima Baltazar; Julieta Afonso. "Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24065141.
    10.3390/ijms24065141
  5. Julieta Afonso; Céline Gonçalves; Marta Costa; Débora Ferreira; Lúcio Santos; Adhemar Longatto-Filho; Fátima Baltazar. "Glucose Metabolism Reprogramming in Bladder Cancer: Hexokinase 2 (HK2) as Prognostic Biomarker and Target for Bladder Cancer Therapy". Cancers (2023): https://doi.org/10.3390/cancers15030982.
    10.3390/cancers15030982
  6. Scialla, Stefania; Hanafy, Mahmoud S.; Wang, Jie-Liang; Genicio, Nuria; Silva, Milene; Costa, Marta; Oliveira-Pinto, Sofia; et al. "Targeted Treatment of Triple-Negative-Breast Cancer Through pH-Triggered Tumour Associated Macrophages Using Smart Theranostic Nanoformulations". International Journal of Pharmaceutics (2023): 122575. http://dx.doi.org/10.1016/j.ijpharm.2022.122575.
    10.1016/j.ijpharm.2022.122575
  7. Sousa, Ana; Pontes, Olívia; Andrade, Juliana; Baltazar, Fátima; Costa, Marta; Proença, Fernanda. "Imidazolylpyrrolone-Based Small Molecules as Anticancer Agents for Renal Cell Carcinoma". ChemMedChem (2022): http://dx.doi.org/10.1002/cmdc.202200519.
    10.1002/cmdc.202200519
  8. Freitas, Ana Sofia; Costa, Marta; Pontes, Olívia; Seidel, Veronique; Proença, Fernanda; Cardoso, Susana M.; Oliveira, Rui; Baltazar, Fátima; Almeida-Aguiar, Cristina. "Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells". Molecules 27 13 (2022): 4001. http://dx.doi.org/10.3390/molecules27134001.
    Aceite para publicação • 10.3390/molecules27134001
  9. Pontes, Olívia; Oliveira-Pinto, Sofia; Baltazar, Fátima; Costa, Marta. "Renal cell carcinoma therapy: Current and new drug candidates". Drug Discovery Today 27 1 (2022): 304-314. http://dx.doi.org/10.1016/j.drudis.2021.07.009.
    10.1016/j.drudis.2021.07.009
  10. Vilaça, Natália; Bertão, Ana Raquel; Prasetyanto, Eko Adi; Granja, Sara; Costa, Marta; Fernandes, Rui; Figueiredo, Francisco; et al. "Surface functionalization of zeolite-based drug delivery systems enhances their antitumoral activity in vivo". Materials Science and Engineering: C 120 (2021): 111721. http://dx.doi.org/10.1016/j.msec.2020.111721.
    Publicado • 10.1016/j.msec.2020.111721
  11. Oliveira-Pinto, Sofia; Pontes, Olívia; Baltazar, Fátima; Costa, Marta. "In vivo efficacy studies of chromene-based compounds in triple-negative breast cancer: A systematic review". European Journal of Pharmacology 887 (2020): 173452. http://dx.doi.org/10.1016/j.ejphar.2020.173452.
    10.1016/j.ejphar.2020.173452
  12. Oliveira-Pinto, Sofia; Pontes, Olívia; Lopes, Diogo; Sampaio-Marques, Belém; Costa, Marta D.; Carvalho, Luísa; Gonçalves, Céline S.; et al. "Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment". Bioorganic Chemistry (2020): 103942. http://dx.doi.org/10.1016/j.bioorg.2020.103942.
    Publicado • 10.1016/j.bioorg.2020.103942
  13. Proença, Fernanda; Lopes, Diogo; Costa, Marta; Louçano, João. "A Convenient One-pot Synthesis of Chromenyl Acrylates and Acrylonitriles". Synlett 31 13 (2020): 1298-1302. http://dx.doi.org/10.1055/s-0039-1690880.
    10.1055/s-0039-1690880
  14. Baltazar, Fátima; Afonso, Julieta; Costa, Marta; Granja, Sara. "Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy". Frontiers in Oncology 10 (2020): http://dx.doi.org/10.3389/fonc.2020.00231.
    Acesso aberto • Publicado • 10.3389/fonc.2020.00231
  15. Olívia Pontes; Marta Costa; Filipa Santos; Belém Sampaio-Marques; Tatiana Dias; Paula Ludovico; Fátima Baltazar; Fernanda Proença. "Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment". European Journal of Medicinal Chemistry 157 (2018): 101-114. https://doi.org/10.1016%2Fj.ejmech.2018.07.058.
    10.1016/j.ejmech.2018.07.058
  16. Pedro Figueiredo; Marta Costa; Olívia Pontes; Fátima Baltazar; Fernanda Proença. "Adenine Derivatives: Promising Candidates for Breast Cancer Treatment". European Journal of Organic Chemistry 2018 29 (2018): 3943-3956. https://doi.org/10.1002/ejoc.201800629.
    10.1002/ejoc.201800629
  17. Costa M; Dias TA; Brito A; Proença F. "Biological importance of structurally diversified chromenes.". (2016): http://europepmc.org/abstract/med/27494166.
    10.1016/j.ejmech.2016.07.057
  18. Lima, C.F.; Costa, M.; Proença, M.F.; Pereira-Wilson, C.. "Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells". European Journal of Pharmaceutical Sciences 72 (2015): 34-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924932107&partnerID=MN8TOARS.
    10.1016/j.ejps.2015.02.019
  19. Lima, CF; Costa, M; Dias, TA; Proença, MF; Pereira-Wilson, C. "Novel synthetic molecules bioinspired in natural phenolic compounds for anticancer drug discovery". Planta Medica 80 16 (2014): http://dx.doi.org/10.1055/s-0034-1394530.
    Publicado • 10.1055/s-0034-1394530
  20. Costa, Marta; Rodrigues, Ana I.; Proença, Fernanda. "Synthesis of 3-aminochromenes: the Zincke reaction revisited". Tetrahedron 70 33 (2014): 4869-4875. http://dx.doi.org/10.1016/j.tet.2014.05.074.
    10.1016/j.tet.2014.05.074
  21. Boot, A.; Brito, A.; Van Wezel, T.; Morreau, H.; Costa, M.; Proença, F.. "Anticancer activity of novel pyrido[2,3-b] indolizine derivatives: The relevance of phenolic substituents". Anticancer Research 34 4 (2014): 1673-1678. http://ar.iiarjournals.org/content/34/4/1673.long.
  22. Costa, Marta; Noro, Jennifer; Brito, Alexandra; Proença, Fernanda. "Tandem Cyclization of a Bispyridinium Chloride: Facile Synthesis of Substituted Indolizines". Synlett 24 17 (2013): 2255-2258. http://dx.doi.org/10.1055/s-0033-1339759.
    10.1055/s-0033-1339759
  23. Areias, Filipe; Costa, Marta; Castro, Marián; Brea, José; Gregori-Puigjané, Elisabet; Proença, M. Fernanda; Mestres, Jordi; Loza, María I.. "New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure–activity relationships". European Journal of Medicinal Chemistry 54 (2012): 303-310. http://dx.doi.org/10.1016/j.ejmech.2012.05.009.
    10.1016/j.ejmech.2012.05.009
  24. Rodrigues, L.C.; Silva, M.M.; Veiga, H.I.M.; Esperança, J.M.S.S.; Costa, M.; Smith, M.J.. "Synthesis and electrochemical characterization of aPEO-based polymer electrolytes". Journal of Solid State Electrochemistry 16 4 (2012): 1623-1629. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862644518&partnerID=MN8TOARS.
    10.1007/s10008-011-1569-3
  25. Costa, Marta; Proença, M. Fernanda. "Selective synthesis of some imidazopyridine-fused chromones". Tetrahedron 67 45 (2011): 8622-8627. http://dx.doi.org/10.1016/j.tet.2011.09.054.
    10.1016/j.tet.2011.09.054
  26. Costa, Marta; Proença, Fernanda. "2-Aryl-1,9-dihydrochromeno[3,2-d]imidazoles: a facile synthesis from salicylaldehydes and arylideneaminoacetonitrile". Tetrahedron 67 10 (2011): 1799-1804. http://dx.doi.org/10.1016/j.tet.2011.01.035.
    10.1016/j.tet.2011.01.035
  27. Proença, Fernanda; Costa, Marta. "A one-pot synthesis of substituted pyrido[2,3-b]indolizines". Tetrahedron 67 6 (2011): 1071-1075. http://dx.doi.org/10.1016/j.tet.2010.12.047.
    10.1016/j.tet.2010.12.047
  28. Costa, Marta; Areias, Filipe; Castro, Marian; Brea, Jose; Loza, María I.; Proença, Fernanda. "Synthesis of novel chromene scaffolds for adenosine receptors". Organic & Biomolecular Chemistry 9 11 (2011): 4242. http://dx.doi.org/10.1039/c1ob05305a.
    10.1039/c1ob05305a
  29. Proença, M. Fernanda; Costa, Marta. "One-pot approach to the synthesis of novel 12H-chromeno[2',3':4,5]imidazo[1,2-a]pyridines in aqueous media". Tetrahedron 66 25 (2010): 4542-4550. http://dx.doi.org/10.1016/j.tet.2010.04.059.
    10.1016/j.tet.2010.04.059
  30. Barbosa, Paula; Rodrigues, Luísa C.; Silva, M. Manuela; Smith, Michael; Costa, Marta. "Synthesis and Thermal Behavior of An Amorphous Solid Polymer Electrolyte". ECS Transactions 25 35 (2010): 383-394. http://dx.doi.org/10.1149/1.3414031.
    10.1149/1.3414031
  31. Costa, Marta; Areias, Filipe; Abrunhosa, Luís; Venâncio, Armando; Proença, Fernanda. "The Condensation of Salicylaldehydes and Malononitrile Revisited:¿ Synthesis of New Dimeric Chromene Derivatives". The Journal of Organic Chemistry 73 5 (2008): 1954-1962. http://dx.doi.org/10.1021/jo702552f.
    10.1021/jo702552f
  32. Proença, Fernanda; Costa, Marta. "A simple and eco-friendly approach for the synthesis of 2-imino and 2-oxo-2H-chromene-3-carboxamides". Green Chemistry 10 9 (2008): 995. http://dx.doi.org/10.1039/b807892k.
    10.1039/b807892k
  33. Abrunhosa, L.; Costa, M.; Areias, F.; Venâncio, A.; Proença, F.. "Antifungal activity of a novel chromene dimer". Journal of Industrial Microbiology & Biotechnology 34 12 (2007): 787-792. http://dx.doi.org/10.1007/s10295-007-0255-z.
    10.1007/s10295-007-0255-z
Capítulo de livro
  1. Olívia Pontes; Ana-Raquel Cunha; Sofia Oliveira-Pinto; Fátima Baltazar; Olga Martinho; Costa, Marta. "Angiogenesis and chromene-based antiangiogenic therapeutic agents". In Anti-Angiogenesis Drug Discovery and Development, 151-188. Bentham eBooks - Bentham Science, 2020.
    Publicado
  2. Costa, Marta; M. Fernanda Proença. "4.2. 3.6. A Simple and Ecological Preparation of a Chromene-3-carboxamide Derivative". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 387. Reino Unido: Royal Society of Chemistry, 2017.
    Publicado
Poster em conferência
  1. Beatriz Sousa; Pontes, Olívia; Andrade, Juliana; Baltazar, Fátima; Fernanda Proença; Costa, Marta. "Synthesis of imidazo-pyridines/diazepines and evaluation of their anticancer potential in renal cell carcinoma cell lines". Trabalho apresentado em XXVII Galician-Portuguese chemistry meeting (Encontro Galego-Portugês de química), 2023.
  2. Vilasboas-Campos, Daniela; Lopes, Joana; Bruna Ferreira-Lomba; Jorge Diogo Da Silva; Costa, Marta Daniela; Rodrigues A.I.; Sousa, A; et al. "Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Organism Phenotypic Assay.". Trabalho apresentado em EMBO Workshop: Proteostasis: From translation to degradation., 2023.
  3. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. "Virtual screening of potential KDM4C inhibitors for the treatment of triple negative breast cancer". Trabalho apresentado em XXVII Encontro Luso-Galego de Química, 2023.
  4. Vilasboas-Campos, Daniela; Lopes, Joana; Ferreira-Lomba, Bruna; Da Silva, Jorge D.; Costa, Marta Daniela; Rodrigues, A.I.; Sousa, A.; et al. "Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Animal Organism Phenotypic Assay". Trabalho apresentado em EMBO Workshop: "Proteostasis: From translation to degradation", 2023.
  5. Costa, Marta; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Carvalho, Luísa; Lopes, Diogo; et al. "Chromene-based molecules: privileged scaffold for oncology drug development". Trabalho apresentado em III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  6. Carvalho, Luísa; Pedroso de Lima, Fábio; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreira, Sara; et al. Autor correspondente: Costa, Marta. "Biological characterization of novel chromeno[2,3-d]pyrimidinones as therapeutic approach for the treatment of triple-negative Breast Cancer". Trabalho apresentado em III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  7. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. Autor correspondente: Sousa, Sofia M.. "Development of virtual screening protocols for the design of novel KDM4C inhibitors for the treatment of triple negative breast cancer". Trabalho apresentado em III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  8. Diogo Lopes; Oliveira-Pinto, Sofia; Pontes, Olívia; Belém Sampaio-Marques; Marta D. Costa; Luísa Carvalho; Céline S. Gonçalves; et al. "Synthesis of chromene[2,3-b]pyridines and characterization of their anticancer potential for the treatment of breast cancer". Trabalho apresentado em III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  9. Beatriz Sousa; Pontes, Olívia; Andrade, Juliana; Baltazar, Fátima; Fernanda Proença; Costa, Marta. "New imidazole based scaffolds for the treatment of renal cell carcinoma". Trabalho apresentado em III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  10. Carvalho, Luísa; Pedroso de Lima, Fábio; Cerqueira, Mónica; Silva. Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreiro, Sara; et al. Autor correspondente: Costa, Marta. "In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer". Trabalho apresentado em 5th National Meeting for Young Researchers in Oncology, 2023.
  11. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. "Optimization of specialized virtual screening protocols for the design of new KDM4C inhibitor molecules for the treatment of triple negative breast cancer". Trabalho apresentado em 5th National Meeting for Young Researchers in Oncology, 2023.
  12. Diogo Lopes; Oliveira-Pinto, Sofia; Pontes, Olívia; Bele´m Sampaio-Marques; Marta D. Costa; Luísa Carvalho; Céline Gonçalves; et al. "Synthesis of chromene[2,3-b]pyridines and characterization of their anticancer potential for the treatment of breast cancer". Trabalho apresentado em 5th National Meeting for Young Researchers in Oncology, 2023.
  13. Beatriz Sousa; Pontes, Olívia; Andrade, Juliana; Fátima Baltazar; Fernanda Proença; Costa, Marta. "New imidazole derivatives as anticancer agents for the treatment of renal cell carcinoma". Trabalho apresentado em 5th National Meeting for Young Researchers in Oncology, 2023.
  14. Vilasboas-Campos, Daniela; Andreia Castro; J Lopes; Bruna Ferreira-Lomba; J.D. Silva; Costa, Marta Daniela; Ana Isabel Rodigues; et al. "Identification of novel molecules with proteostasis enhancement activity using a whole-animal based fast-throughput phenotypic assay". Trabalho apresentado em 6th Symposium on Medicinal Chemistry, 2023.
  15. Ana Silva; Cerqueira, Mónica; Beatriz Rosa; Catarina Sobral; Filipa Pinto-Ribeiro; Costa, Marta; Fátima Baltazar; Julieta Afonso. "Prognostic value of monocarboxylate transporter 1 overexpression in cancer: a systematic review". Trabalho apresentado em XXIX PORTO CANCER MEETING - Glycosylation in tumour biology and its clinical implications, 2023.
  16. Cerqueira, Mónica; Efres Belmonte-Reche; Céline Gonçalves; Costa, Marta; Raquel Rainha; Juan Gallo; Manuel Bañobre; Baltazar, Fátima. "Treatment of triple-negative breast cancer through externally triggered target-less drug carriers". Trabalho apresentado em XXIX PORTO CANCER MEETING - Glycosylation in tumour biology and its clinical implications, 2023.
  17. Beatriz Ferreira; Beatriz Sousa; Costa, Marta; Fernanda Proença. "Studies on the acylation reaction of salicylaldehyde". Trabalho apresentado em 5th Symposium on Medicinal Chemistry of University of Minho, 2022.
  18. Diogo Lopes; Costa, Marta; Oliveira-Pinto, Sofia; Pontes, Olívia; Carvalho, Luísa; Fátima Baltazar; Fernanda Proença. "Chromen[2,3-b]pyridines: synthesis and evaluation of the anticancer potential for breast cancer treatment". Trabalho apresentado em XXVI Galician-Portuguese chemistry meeting (Encontro Galego-Portugês de química), 2022.
  19. Beatriz Sousa; Diogo Costa; Costa, Marta; Fernanda Proença. "Studies on the synthesis of new heterocycles based on the chromene and purine nucleus". Trabalho apresentado em XXVI Galician-Portuguese chemistry meeting (Encontro Galego-Portugês de química), 2022.
  20. Mónica Cerqueira; Efres Belmonte-Reche; Costa, Marta; Fátima Baltazar; Juan Gallo; Manuel Bañobre-López. "In vitro validation of a new magnetic solid lipid nanoformulation against Triple-Negative Breast Cancer". Trabalho apresentado em II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer, 2021.
  21. Mónica Cerqueira; Efres Belmonte-Reche; Costa, Marta; Fátima Baltazar; Juan Gallo; Manuel Bañobre-López. "Validation of a new nanoformulation for the diagnostic and treatment of triple-negative breast cancer". Trabalho apresentado em 3rd National Meeting for Young Researchers in Oncology (ENJIO), 2021.
  22. Costa, Marta; Pontes, Olívia; Oliveira-Pinto, Sofia; Céline Gonçalves; Sara Duarte-Silva; Belém Sampaio-Marques; Carlos Bessa; et al. "A new lead compound for triple negative breast cancer therapy". Trabalho apresentado em XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021), 2021.
  23. Pontes, Olívia; Oliveira-Pinto, Sofia; Belém Sampaio-Marques; Ana Carolina Laus; Luciane S. da Silva; Paula Ludovico; Rui M. Reis; et al. "New chromene derivatives: overcoming renal cell carcinoma drug resistance". Trabalho apresentado em XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021), 2021.
  24. Julieta Afonso; Rita Vale Lima ; Helena Gomes; Joana Moutinho; Céline Gonçalves; Marta Costa; Lúcio Santos; Adhemar Longatto; Fátima Baltazar. "Hexokinase II (HKII) is a prognostic biomarker for bladder cancer patients: Antitumoral activity of the HKII inhibitor 2-deoxy-D-glucose". Trabalho apresentado em EACR 2021, Innovative Cancer Science, 2021.
  25. Pontes, Olívia; Oliveira-Pinto, Sofia; Belém Sampaio-Marques; Luciane S. da Silva ; Ana Carolina Laus; Paula Ludovico; Rui M. Reis ; et al. "Novel therapy for renal cell carcinoma: overcoming drug resistance". Trabalho apresentado em EACR 2021 Virtual Congress: Innovative Cancer Science, 2021.
  26. Costa, Marta; Pontes, Olívia; Céline Gonçalves; Sara Duarte-Silva; Belém Sampaio-Marques; Paula Ludovico; Bruno M. Costa; et al. "A new therapeutic option for triple negative breast cancer". Trabalho apresentado em EACR 2021 Virtual Congress: Innovative Cancer Science, 2021.
  27. Ferreira, Débora; Costa, Marta; Fátima Baltazar; Kalluri, Raghu; João N. Moreira; Rodrigues, Ligia R.. "Engineered exosome-mediated delivery of RNAi therapeutics towards triple negative breast cancer therapy". Trabalho apresentado em EACR 2021 Virtual Congress: Innovative Cancer Science, 2021.
  28. Julieta Afonso; Rita Lima ; Helena Gomes; Joana Moutinho; Céline Gonçalves; Costa, Marta; Lúcio Santos; Adhemar Longatto; Fátima Baltazar. "Upregulation of Hexokinase II (HKII) impacts survival of bladder cancer patients: Effects of HKII inhibition by 2-deoxy-D-glucose". Trabalho apresentado em 27th Porto Cancer Meeting, 2021.
  29. Ana Sofia Freitas; Costa, Marta; Pontes, Olívia; Véronique Seidel; Susana M. Cardoso; Rui Oliveira; Cristina Almeida-Aguiar. "Anti-cancer activity of Portuguese propolis fractions and isolated compounds". Trabalho apresentado em 27th Porto Cancer Meeting, Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  30. Mónica Cerqueira; Efres Belmonte-Reche; Costa, Marta; Fátima Baltazar; Juan Gallo; Manuel Bañobre-López. "In vitro validation of a new theranostic nanoformulation against Triple-Negative Breast Cancer". Trabalho apresentado em 27th Porto Cancer Meeting, Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  31. Mónica Cerqueira; Efres Belmonte-Reche; Costa, Marta; Fátima Baltazar; Juan Gallo; Manuel Bañobre-López. "In vitro validation of a new magnetic formulation against Triple-Negative Breast Cancer". Trabalho apresentado em EuroNanoForum 2021, 2021.
  32. Costa, Marta; Olívia Pontes; Sofia Oliveira-Pinto; Belém Sampaio-Marques; Sara Duarte-Silva; Carlos Bessa; Paula Ludovico; et al. "Unravelling the anticancer potential of novel compounds for breast cancer therapy". Trabalho apresentado em Cancer Biology: From Basic to Translational Research - Webinar, 2020.
  33. Sofia Oliveira-Pinto; Olívia Pontes; Diogo Lopes; Belém Sampaio-Marques; Marta D. Costa; Luísa Carvalho; Céline S. Gonçalves; et al. "Characterization of the biological activity of functionalized chromeno[2,3-b]pyridines for breast cancer treatment". Trabalho apresentado em Cancer Biology: From Basic to Translational Research - Webinar, 2020.
  34. Luísa Carvalho; Sofia Oliveira-Pinto; Olívia Pontes; Fábio Pedroso de Lima; Fernanda Proença; Fátima Baltazar; Costa, Marta. "New substituted 3,5-dihydro-4H-chromeno [2,3-d] pyrimidin-4-one: a promising strategy for breast cancer treatment". Trabalho apresentado em Cancer Biology: From Basic to Translational Research - Webinar, 2020.
  35. Olívia Pontes; Céline S. Gonçalves; Sara Duarte-Silva; Belém Sampaio-Marques; Carlos Bessa; Paula Ludovico; Bruno M. Costa; et al. "New chromene derivatives: unravelling the molecular mechanisms for breast cancer treatment". Trabalho apresentado em 13th Biological and Medicinal Chemistry Postgraduate Symposium, Cambridge (United Kingdom), 2019.
  36. Olívia Pontes; Costa, Marta; Sofia Oliveira-Pinto; M. Fernanda Proença; Fátima Baltazar. "Chromene derivatives: a new strategy to overcome renal cancer resistance". Trabalho apresentado em 9th Annual ISCaM Meeting 2019 – Cancer Metabolic Rewiring: Mapping the Road to Clinical Translation, Braga (Portugal), 2019.
  37. Sofia Oliveira-Pinto; Olívia Pontes; Belém Sampaio-Marques; Paula Ludovico; M. Fernanda Proença; Fátima Baltazar; Marta Costa. "New molecules based on chromene moiety as candidates for renal cell carcinoma therapy". Trabalho apresentado em 1st National Meeting for Young Researchers in Oncology (ENJIO), IPO, Porto (Portugal), 2019.
  38. Luísa Carvalho; Sofia Oliveira-Pinto; Olívia Pontes; Diogo Lopes; Beatriz Ferreira; M. Fernanda Proença; Fátima Baltazar; Costa, Marta. "Synthesis and biological activity of new anticancer agents for breast cancer treatment". Trabalho apresentado em 1st National Meeting for Young Researchers in Oncology (ENJIO), IPO, Porto (Portugal), 2019.
  39. Olívia Pontes; Belém Sampaio-Marques; Sara Duarte-Silva; Carlos Bessa; Paula Ludovico; Patrícia Maciel; M. Fernanda Proença; Costa, Marta. "Exploitation of novel chromene derivatives for breast cancer treatment". Trabalho apresentado em 1st National Meeting for Young Researchers in Oncology (ENJIO), IPO, Porto (Portugal), 2019.
  40. Sofia Oliveira-Pinto; Olívia Pontes; Belém Sampaio-Marques; Paula Ludovico; M. Fernanda Proença; Fátima Baltazar; Costa, Marta. "Chromene-based compounds as candidates for renal cell cancer treatment". Trabalho apresentado em RICT2019: 55th International Conference on Medicinal Chemistry, Nantes (France), 2019.
  41. Olívia Pontes; Belém Sampaio-Marques; Sara Duarte-Silva; Carlos Bessa; Paula Ludovico; Patrícia Maciel; Fátima Baltazar; M. Fernanda Proença; Costa, Marta. "New chromene derivatives: Unraveling the molecular mechanisms for breast cancer therapy". Trabalho apresentado em RICT2019: 55th International Conference on Medicinal Chemistry, Nantes (France), 2019.
  42. Ana Raquel Bertão; Natália Vilaça; Sara Granja; Costa, Marta; Pier Parpot; António M. Fonseca; Manuel Bañobre; Fátima Baltazar; Isabel C. Neves. "In vitro and in vivo efficacy evaluation of drug delivery systems based on zeolites". Trabalho apresentado em NanoMed Europe - NME19, 2019.
  43. Diogo Lopes; Sofia Oliveira-Pinto; João Louçano; Fátima Baltazar; Costa, Marta; M. Fernanda Proença. "Synthesis of functionalized chromeno[2,3-b]pyridines: promising agents for breast cancer treatment". Trabalho apresentado em 4th Symposium on Medicinal Chemistry, University of Minho, Braga (Portugal), 2019.
  44. Sofia Oliveira-Pinto; Olívia Pontes; Belém Sampaio-Marques; Paula Ludovico; M. Fernanda Proença; Fátima Baltazar; Costa, Marta. "Biological activity of novel targeted inhibitors for renal cell cancer therapy". Trabalho apresentado em 26th Porto Cancer Meeting and 5th Joint Meeting Porto-Bordeaux, Porto (Portugal), 2019.
  45. Olívia Pontes; Belém Sampaio-Marques; Sara Duarte-Silva; Carlos Bessa; Paula Ludovico; Patrícia Maciel; M. Fernanda Proença; Fátima Baltazar; Costa, Marta. "In vitro and in vivo evaluation of new chromene derivatives as potent anticancer agents". Trabalho apresentado em 26th Porto Cancer Meeting and 5th Joint Meeting Porto-Bordeaux, Porto (Portugal), 2019.
  46. Sofia Oliveira-Pinto; Olívia Pontes; M. Fernanda Proença; Fátima Baltazar; Costa, Marta. "Chromene-based molecules as targeted inhibitors for renal cell cancer therapy". Trabalho apresentado em ICVS Open Week, Braga (Portugal), 2019.
  47. Olívia Pontes; Costa, Marta; Tatiana Dias; Filipa Santos; Belém Sampaio-Marques; Fátima Baltazar; M. Fernanda Proença. "New chromene-based molecules as microtubule destabilizers and pro-apoptotic agents in cancer". Trabalho apresentado em Making it Personal: Cancer Precision Medicine, Bergamo (Italy), 2018.
  48. Olívia Pontes; Costa, Marta; Filipa Santos; Belém Sampaio-Marques; Fátima Baltazar; M. Fernanda Proença. "Chemical and biological characterization of chalcones and 4H-chromenes: exploitation as anticancer agents". Trabalho apresentado em 3rd ASPIC International Congress, Lisbon, (Portugal), 2018.
  49. Olívia Pontes; Costa, Marta; Filipa Santos; Belém Sampaio-Marques; Paula Ludovico; M. Fernanda Proença; Fátima Baltazar. "Discovery of chromene-based molecules as apoptosis-inducers by G2/M cell-arrest". Trabalho apresentado em 25th Porto Cancer Meeting, Porto (Portugal), 2018.
  50. Olívia Pontes; Costa, Marta; Filipa Santos; Belém Sampaio-Marques; Paula Ludovico; M. Fernanda Proença; Fátima Baltazar. "Unraveling the anticancer molecular mechanisms of new chromene-based drugs". Trabalho apresentado em ICVS Open Week, Braga (Portugal), 2018.
  51. Olívia Pontes; Costa, Marta; Filipa Santos; Belém Sampaio-Marques; Fátima Baltazar; M. Fernanda Proença. "Chromene-based drug candidates for cancer treatment". Trabalho apresentado em 12nd National Meeting of Organic Chemistry/5th National Meeting of Medicinal Chemistry, Coimbra (Portugal), 2018.
  52. Olívia Pontes; Costa, Marta; Filipa Santos; Sara Granja; Fátima Baltazar; M. Fernanda Proença. "New chromene-based drug candidates for cancer treatment". Trabalho apresentado em I Symposium on Applied Biochemistry, Braga (Portugal), 2017.
  53. Olívia Pontes; Costa, Marta; Filipa Santos; M. Fernanda Proença; Fátima Baltazar. "Chromene derivatives as anticancer agents: synthesis and biological evaluation". Trabalho apresentado em 2nd ASPIC International Congress, Porto (Portugal), 2016.
  54. Costa, Marta; Filipa Santos; Alexandra Brito; Ângela Fernandes; Maria M. Azevedo; Tatiana Lourenço; Paula Ludovico; et al. "Chromene-based new drug candidates for cancer treatment". Trabalho apresentado em 2nd ASPIC International Congress, Porto (Portugal), 2016.
  55. João Louçano; Costa, Marta; M. Fernanda Proença. "Reactivity of 3-pyridinium coumarins with carbon nucleophiles". Trabalho apresentado em 2nd Symposium on Medicinal Chemistry, Braga (Portugal), 2015.
  56. Costa, Marta; Filipa Santos; Alexandra Brito; Ângela Fernandes; Maria M. Azevedo; Tatiana Lourenço; Paula Ludovico; et al. "Anticancer profile of a selection of new chromene-based compounds". Trabalho apresentado em XXIII Porto Cancer Meeting - Stem Cells and Cancer, Porto (Portugal), 2015.
  57. Costa, Marta; Cristóvão F. Lima; M. Fernanda Proença; Cristina Pereira-Wilson. "Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells". Trabalho apresentado em EFMC-ISMC 2014 23nd International Symposium on Medicinal Chemistry, Lisbon (Portugal), 2014.
  58. Tatiana A. Dias; Costa, Marta; M. Fernanda Proença. "Some reactions of active methylene compounds with 2-hydroxychalcones". Trabalho apresentado em 10th National Meeting of Organic Chemistry (ENQO), Lisbon (Portugal), 2013.
  59. Rodrigues A.; Costa, Marta; Proença, F.. "3-aminocoumarins: synthesis and reaction with active carbonyl compounds". Trabalho apresentado em 10th National Meeting of Organic Chemistry (ENQO), Lisbon (Portugal), 2013.
  60. Proença, F.; Costa, Marta; Areias, F.; Castro, M.; Brea, J; Loza, M. "Synthesis of new chromene derivatives and pharmacological evaluation for adenosine receptors". Trabalho apresentado em 10th National Meeting of Organic Chemistry (ENQO), Lisbon (Portugal), 2013.
  61. Costa, Marta; Brito, A.; Proença, F.. "Pyrido[2,3-b]indolizines: a one-pot synthesis in green media". Trabalho apresentado em 10th National Meeting of Organic Chemistry (ENQO), Lisbon (Portugal), 2013.
  62. Ana Gonçalves; Costa, Marta; M. Fernanda Proença. "Synthesis of new chromene derivatives as potencial anticancer agents". Trabalho apresentado em 3rd National Meeting on Medicinal Chemistry, Aveiro (Portugal), 2012.
  63. Ana I. Rodrigues; Costa, Marta; M. Fernanda Proença. "Synthesis of 1-(2-imino-2H-chromen-3-yl)pyridinium chloride derivatives as potential anticancer agents". Trabalho apresentado em 3rd National Meeting on Medicinal Chemistry, Aveiro (Portugal), 2012.
  64. M. Fernanda Proença; Costa, Marta; Olga Pereira; Cristóvão F. Lima; Cristina Pereira-Wilson. "Synthesis and anticancer activity of novel chromeno-imidazo[1,2-a]pyridines". Trabalho apresentado em EFMC-ISMC 2012 22nd International Symposium on Medicinal Chemistry, Berlin (Germany), 2012.
  65. Costa, Marta; Filipe Areias; Marian Castro; Jose Brea; María I. Loza; M. Fernanda Proença. "Synthesis and pharmacological evaluation of new chromene scaffolds for adenosine receptors". Trabalho apresentado em EFMC-ISMC 2012 22nd International Symposium on Medicinal Chemistry, Berlin (Germany), 2012.
  66. E. Marinho; Costa, Marta; M. Fernanda Proença; F. Areias; M. Castro; J. Brea; J. Mestres; M. Loza. "N-Methyl piperazine: an important fragment for interaction with serotonine 5-HT2a receptors". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry, Coimbra (Portugal), 2010.
  67. F. Areias; Costa, Marta; M. Castro; J. Brea; J. Mestres; M. Fernanda Proença; M. Loza. "New scaffold for adenosine receptors". Trabalho apresentado em 2nd European Chemical Biology Symposium, Prague (Czech Republic), 2010.
  68. I. Kuzniarska-Biernacka; Costa, Marta; J. Fonseca; K. Biernacki; A. Magalhães; C. Freire; M. Fernanda Proença. "Characterisation and catalytic activity of copper(II) complexes with chromene derivatives". Trabalho apresentado em 8th Inorganic Chemistry Conference, Cúria (Portugal), 2009.
  69. Costa, Marta; Elina Marinho; M. Fernanda Proença. "Synthesis of aryl piperazine derivatives as potential antipsychotics". Trabalho apresentado em 8th National Meeting of Organic Chemistry (ENQO), Aveiro (Portugal), 2009.
  70. Costa, Marta; M. Fernanda Proença. "Synthesis of 12H-chromeno[2´,3´:4,5]imidazo[1,2-a]pyridine by a base catalysed cascade cyclisation approach". Trabalho apresentado em 10th Tetrahedron Symposium: Challenges in Organic and Bioorganic Chemistry, Paris (France), 2009.
  71. Costa, Marta; F. Areias; J. Brea; M. I. Loza. "Synthesis of 2-imino-2H-chromene-3-carboxamides with affinity for serotonin receptors". Trabalho apresentado em 1st National Meeting on MedicinalChemistry, Porto (Portugal), 2008.
  72. Costa, Marta; M. Fernanda Proença. "A simple and eco-friendly approach for the synthesis of 2-imino-2H-chromene-3-carboxamides". Trabalho apresentado em 23rd European Colloquium on Heterocyclic Chemistry (ECHC XXIII), Antwerp (Belgium), 2008.
  73. M. Fernanda Proença; Costa, Marta. "Synthesis and in vitro antifungal activity of a novel chromene derivative". Trabalho apresentado em 7th National Meeting of Organic Chemistry (ENQO), Lisbon (Portugal), 2007.
  74. M. Fernanda Proença; Costa, Marta. "The Reaction of 2-Oxo-2H-chromene-3-carbonitrile with 2-Methoxyethylamine". Trabalho apresentado em 4th Spanish-Portuguese-Japanese Organic Chemistry Symposium, Santiago de Compostela (Spain), 2006.
  75. M. Fernanda Proença; Costa, Marta. "Some Reactions of (2-amino-3-cyano-4H-chromen-4-yl)malononiytile". Trabalho apresentado em 4th Transmediterranean Colloquium on Heterocyclic Chemistry (TRAMECH), Aveiro (Portugal), 2006.
  76. Filipe Areias; A.P. Bettencourt; F. Fernandes; M. Fernanda Proença; Costa, Marta. "The Condensation of Aromatic Aldehydes and Malononitrile Revisited". Trabalho apresentado em 6th National Meeting of Organic Chemistry (ENQO), Braga (Portugal), 2006.
Resumo em conferência
  1. Cristóvão F. Lima; Costa, Marta; Tatiana Dias; Maria Fernanda R. Paiva Proença; Fátima Baltazar. "Novel synthetic molecules bioinspired in natural phenolic compounds for anticancer drug discovery". Trabalho apresentado em Planta Medica - 62nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research, 2014.
    Publicado

Propriedade Intelectual

Patente
  1. Costa, Marta; Fátima Balazar; Maria Fernanda Rego Paiva Proença; Pedro Ferreira; Maria Isabel Veiga; Carla Calçada. 2021. "ANTIMALARIAL AGENT, METHODS AND USES THEREO - Internacional Patent".
    Pendente
  2. Costa, Marta; Maria Fernanda R. Paiva Proença; Fátima Baltazar; Patrícia Maciel; Olívia Pontes. 2020. "CHROMENE-BASED COMPOUNDS, METHODS AND USES THEREOF - International Patent".
    Pendente
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/12/18 Design of novel KDM4C inhibitors for the treatment of triple negative breast cancer 3D-BioInfo-PT
(Coimbra, Portugal)
2023/11/23 Synthesis of chromene[2,3-b]pyridines: reactivity studies and anticancer potential for the treatment of breast cancer XXVII Galician-Portuguese chemistry meeting (Encontro Galego-Portugês de química)
(Porto, Portugal)
2023/11/23 A new method for the synthesis of 2-cyanomethyl benzimidazole derivatives XXVII Galician-Portuguese chemistry meeting (Encontro Galego-Portugês de química)
(Porto, Portugal)
2023/09/22 In vitro and in vivo evaluation of new chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer 5th National Meeting for Young Researchers in Oncology (ENJIO)
Portuguese League Against Cancer (LPCC-NRN) (Porto, Portugal)
2023/06/15 o-Diamines as precursors for the synthesis of active methylene compounds 6th Symposium on Medicinal Chemistry
University of Minho (Braga, Portugal)
2023/05/23 Innovative treatment for aggressive cancers (Tratamento inovador para cancros agressivos) Pinto of Science, 6th edition
Pinto of Science (Braga)
2022/10/24 Exploitation of novel synthetic compounds as agents for breast cancer therapy Molecular Foundations of Cancer Course of the Medical Degree (2nd year), University of Minho
University of Minho, School of Medicine (Braga, Portugal)
2022/10/20 Unlocking new therapies for cancer StageTwo
RWTH Aachen University & HHL Leipzig Graduate School of Management (Berlin, Alemanha)
2022/09/24 Treatment of triple-negative breast cancer using externally activated solid-lipid nanoparticles 4th National Meeting of Young Researcher in Oncology
Portuguese League Against Cancer (LPCC-NRN)
2022/06/02 Karion Therapeutics - Unlocking new therapies IU-CAN: Universities as an Interface for Entrepreneurship
Universidade da Beira Interior (UBI)
2022/05/26 Karion Therapeutics - Unlocking new therapies Laboratório de Empresas (Business Laboratory)
TecMinho, University of Minho
2022/04/22 Karion Therapeutics - Unlocking new therapies SpinUM
TecMinho, University of Minho
2022/01/26 Exosome-mediated MEK1 silencing is a promising approach against triple negative breast cancer regression XIV Spanish-Portuguese Conference on Controlled Drug Delivery
2021/10/25 Exploitation of novel synthetic compounds as agents for breast cancer therapy Molecular Foundations of Cancer Course of the Medical Degree (2nd year), University of Minho
School of Medicine, University of Minho (Braga)
2021/07/14 MOON Therapeutics - Molecules for Oncology HiTech 2021 Closing Session
HiSeedTech (Portugal)
2021/04/29 3H-Chromeno[2,3-d]Pyrimidin-4(5H)-ones - Synthesis and biological evaluation as anticancer agents 13th Young Medicinal chemist Virtual symposium
(Florence, Itália)
2021/01/29 Characterization of the activity of novel chromene derivatives for cancer therapy II Symposium on Biochemistry
University of Minho - School of Science (Chemistry Department) (Braga, Portugal)
2020/10 A new therapeutic strategy for triple negative breast cancer TMex - Translational Medicine explained course
European infrastructure for translational medicine (EATRIS)
2020/09/24 Caracterização da atividade biológica de cromeno[2,3-b]piridinas funcionalizadas para o tratamento do cancro da mama 2nd National Meeting of Young Researcher in Oncology
Portuguese League Against Cancer (Liga Portuguesa contra o Cancro) (Porto, Portugal)
2020/09/16 Novel chromene-based compounds for triple-negative breast cancer therapy Ciência Falada (Science Forum)
School of Medicine, University of Minho
2019/12/13 New chromene derivatives: unravelling the molecular mechanisms for breast cancer treatment 13th Biological and Medicinal Chemistry Postgraduate Symposium
Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry (Cambridge, Reino Unido)
2019/11/20 Synthesis of imidazole derivatives and evaluation of the anticancer potential on renal cell carcinoma XXVI Galician-Portuguese chemistry meeting (Encontro Galego-Portugês de química)
SPQ and Colégio Oficial de Químicos da Galiza (COLQUIGA) (Santiago de Compostela, Espanha)
2019/10/14 Breast Cancer - awareness / prevention Awareness-raising action - Breast Cancer
Portuguese League Against Cancer and Escola Profissional Amar Terra Verde (Vila Verde, Portugal)
2019/05/24 Synthesis of imidazo-pyridine derivatives for mTOR inhibition 4th Symposium on Medicinal Chemistry
Chemistry Department from the University of Minho (Braga, Portugal)
2015/12/01 1-(2-Oxo-2H-chromen-3-yl)pyridinium Chloride: Subtleties in the Reaction with Nucleophiles 11º National Meeting of Organic Chemistry/4º National Meeting of Medicinal Chemistry
Organic and Medicinal Chemistry divisions of the Portuguese Chemical Society (SPQ) (Porto, Portugal)
2014/08/31 Novel synthetic molecules bioinspired in natural phenolic compounds for anticancer drug discovery 62nd International Congress and Annual Meeting of Society for Medicinal Plant and Natural Product Research – GA2014
Society for Medicinal Plant and Natural Product Research (GA) (Guimarães, Portugal)
2013/09/04 Chromeno-imidazo[1,2-a]pyridines: synthesis and anticancer activity 10th National Meeting of Organic Chemistry (ENQO), Lisbon (Portugal)
Organic Chemical Division of the Portuguese Chemical Society (Lisbon, Portugal)
2012/05/09 New chromene scaffolds for adenosine receptors: synthesis and pharmacology 3rd Portuguese Young Chemists Meeting (3PYChem)
Portuguese Young Chemist divisions of the Portuguese Chemical Society (SPQ) (Porto, Portugal)
2010/04/21 One-pot condensation-cyclization approach for the synthesis of 12H-chromeno[2´,3´:4,5]imidazo[1,2-a]pyridine 2nd Portuguese Young Chemists Meeting (2PYChem)
Grupo de Químicos Jovens (GQJ) da Sociedade Portuguesa de Química (SPQ) (Aveiro, Portugal)
2010 Synthesis of novel chromene-based scaffolds for adenosine receptors 2nd National Meeting on Medicinal Chemistry
Medicinal Chemistry divisions of the Portuguese Chemical Society (SPQ) (Coimbra, Portugal)
2007/10/29 Aldehyde activation by simple nucleophilic reagents: two different approaches 2nd ERA-Chemistry Flash Conference - Catalysis without metals
(Évora, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/09/01 - 2026/08/31 Novel KDM4C inhibitors for the treatment of triple negative breast cancer: rational design, synthesis and biological validation
Orientador de Sofia Sousa
 PhD In Health Sciences (Doutoramento)
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
2022/09/01 - 2026/08/31 Novel chromene-based compounds as candidates for bladder cancer therapeutics
Coorientador de Ana Isabel Silva
 PhD in Health Sciences (Doutoramento)
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
2022/09/01 - 2026/08/31 Exploitation of a novel drug candidate for renal cell carcinoma therapy
Orientador de Mónica Cerqueira
 PhD in Health Sciences (Doutoramento)
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
2021/01/01 - 2025/12/31 New imidazole and chromene-based scaffolds for a multi-target approach on breast cancer therapy
Coorientador de Ana Beatriz Pereira de Sousa
 Doctoral Degree Program in Chemistry (Doutoramento)
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal

Universidade do Minho Departamento de Química, Portugal
2020/11/01 - 2024/10/31 Chromene-based molecules for triple negative breast cancer therapy: synthesis, nanoencapsulation and biological studies
Coorientador de Diogo Alexandre Vilaça Lopes
 Doctoral Degree Program in Chemistry (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho Departamento de Química, Portugal
2022/05/01 - 2023/10/31 Exploiting novel options for triple-negative breast cancer treatment: combination studies of classical therapeutics with the new drug candidate SMT01
Orientador de Maria Dolores Mendes Borges
Master's degrees Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
2021/09/01 - 2022/10/31 Studies for the large-scale production of chromene-based tricyclic molecules
Orientador de Beatriz Ferreira
 Master's degrees in Medicinal Chemistry (Mestrado)
Universidade do Minho Departamento de Química, Portugal
2017/10/01 - 2022/04/26 Characterization of the anticancer efficacy and safety profiles of novel synthetic compounds
Orientador de Olívia Alexandra Elias Pontes
 PhD in Health Sciences (PhDCS) (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/09/01 - 2021/07/29 New chromene derivatives: synthesis and anticancer activity
Orientador de Diogo Costa
 Master's degrees in Medicinal Chemistry (Mestrado)
Universidade do Minho Departamento de Química, Portugal

Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
2021/03/01 - 2021/06/09 Anticancer activity study of new heterocyclic compounds for the treatment of renal cell carcinoma
Orientador de Rita Fernandes Alves
 Medical Degree (Iniciação científica)
Universidade do Minho Escola de Medicina, Portugal
2021/03 - 2021/06 Characterization of the anticancer activity of new compounds for the treatment of renal cell carcinoma
Orientador de Ana Catarina Machado Pereira
 Degree in Biochemistry (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/03 - 2021/06 Exploitation of chromene-based compounds as PLD1 modulators for the treatment of triple negative breast cancer
Orientador de Ana Carolina Ferreira Martins
 Degree in Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/09/01 - 2021/03/31 Exploitation of new chromene-based compounds as promising agents for cancer treatment
Orientador de Ana Luísa Carvalho
 Master's degrees in Applied Biochemistry (Mestrado)
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
2020/05/01 - 2020/12/31 Biological activity of novel targeted inhibitors for renal cell cancer therapy
Orientador de Joana Isabel Neto Gomes
 Integrated Master in Medicine (final master project) (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
2019/03/01 - 2019/07/31 Imagiological techniques for tumor volume estimation in the CAM model: comparative studies
Orientador de Sara Alexandra Carvalho Lopes de Freitas
 Degree in Physics (Licenciatura/Bacharelato)
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal

Universidade do Minho Departamento de Física, Portugal
2019/03/01 - 2019/06/30 Exploitation of new chromenes as promising agents for the treatment of cancer
Orientador de Beatriz Rocha Ferreira
 Degree in Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal

Universidade do Minho Departamento de Biologia, Portugal
2018/10/01 - 2019/02/28 Exploitation of chromenes as promising anticancer agents
Orientador de Ana Isabel Oliveira
 Degree in Biochemistry (Licenciatura/Bacharelato)
Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal
2018/09/01 - 2019 Synthesis of aromatic heterocycles with potential biological activity
Orientador de Ana Beatriz Pereira de Sousa
 Master's degrees in Medicinal Chemistry (Mestrado)
Universidade do Minho Departamento de Química, Portugal
2018/09/01 - 2019 Characterization of the activity of novel chromene derivatives for cancer therapy
Orientador de Sofia Oliveira-Pinto
 Master's degrees in Applied Biochemistry - Biomedicine (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho Departamento de Biologia, Portugal
2017/09/01 - 2018/11/30 The reaction of salicylaldehyde with activated methylene compounds: product characterization and reactivity studies
Orientador de Diogo Alexandre Vilaça Lopes
 Master's degrees in Medicinal Chemistry (Mestrado)
Universidade do Minho Departamento de Química, Portugal
2018/03/01 - 2018/06/30 New targeted KIT oncogene inhibitors for the treatment of Gastrointestinal Stromal Tumors
Orientador de Patrícia Fernandes Fontão
 Degree in Biochemistry (Licenciatura/Bacharelato)
Universidade do Minho Departamento de Biologia, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/05/01 - 2017/07/31 Design and Synthesis of Donor-Acceptor Adducts
Orientador
 ERASMUS program (international mobilization internships from France) (Curso de aperfeiçoamento / especialização)
Universidade do Minho Departamento de Química, Portugal
2017/03/01 - 2017/06/30 Exploitation of the biological activity of novel compounds for the treatment of cancer
Orientador de Sofia Olíveira-Pinto
 Degree in Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Departamento de Biologia, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/09/01 - 2016/11/29 New Chromene-based drug candidates for cancer treatment
Orientador de Olívia Pontes
 Master's degrees in Medicinal Chemistry (Mestrado)
Universidade do Minho Departamento de Química, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/09/01 - 2015/11/30 Reactivity studies on chromene derivatives
Orientador de João Gomes
 Master's degrees in Medicinal Chemistry (Mestrado)
Universidade do Minho Departamento de Química, Portugal
2015/03/01 - 2015/07/31 Synthesis of novel chromene derivatives and anticancer evaluation
Orientador de Madalena Nunes Monteiro
 Degree in Biochemistry (Licenciatura/Bacharelato)
Universidade do Minho Departamento de Biologia, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/09/01 - 2013/11/30 Synthesis of chromene derivatives as potential anticancer agents
Orientador de Ana Alexandra Gonçalves
 Master's degrees in Medicinal Chemistry (Mestrado)
Universidade do Minho Departamento de Química, Portugal
2012/09/01 - 2013/11/30 Synthesis of novobiocin analogues as potential anticancer agents
Orientador de Ana Isabel Rodrigues
 Master's degrees in Medicinal Chemistry (Mestrado)
Universidade do Minho Departamento de Química, Portugal
2013/02/01 - 2013/07/31 Establish a relationship between the structure of the compounds and the activity in the colorectal cancer cell lines and also to study the pathways that the compounds are affecting
Orientador
 ERASMUS+ program (Curso de aperfeiçoamento / especialização)
Universidade do Minho, Portugal

Leids Universitair Medisch Centrum, Países Baixos
2013/03/01 - 2013/06/30 Synthesis and reactivity studies of piridinium salts
Orientador de Jennifer Martins Noro
Degree in Chemistry (Licenciatura/Bacharelato)
Universidade do Minho Departamento de Química, Portugal
2013/02/01 - 2013/06/30 Evaluate the effect of the new compound derivatives on different thyroid and colorectal cancer cell lines
Orientador de Ana Alexandra Brito
 Leonardo da Vinci Program for recent graduated MSc students (Outra)
Universidade do Minho Departamento de Química, Portugal

Leids Universitair Medisch Centrum, Países Baixos

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/10/17 - 2019/10/19 ISCaM2019 - 6th Annual meeting (2019/10/17 - 2019/10/17)
Congresso (Membro da Comissão Organizadora)
 Universidade do Minho - Instituto de Ciências da Vida e da Saúde (ICVS), Portugal
2005/06/19 - 2005/06/21 6th National Meeting of Organic Chemistry (ENQO) (2005/06/19)
Congresso (Outra)
 Universidade do Minho Departamento de Química, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023/12/13 - Atual Human Book - researcher in cancer: online round table discussion with high school students about cancer (awareness, risk factors and prevention)
Mesa-redonda
 Human Library - Cancer
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2023/12/12 - Atual Human Book - researcher in cancer: round table discussion with high school students about cancer (awareness, risk factors and prevention)
Mesa-redonda
 Human Library - Cancer
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2023/11/09 - Atual Female Founder Office Hours Edition 10
Oficina (workshop)
 Female Founder Office Hours
Playfair Capital, Reino Unido
2023/12/05 - 2023/12/06 EACR - AstraZeneca Conference on Cancer Epigenetics
Seminário
 Cancer Epigenetics
European Association For Cancer Research, Reino Unido
2023/11/13 - 2023/11/16 Web Summit 2023
Exposição
 Web Summit
Web Summit, Portugal
2023/10/26 - 2023/10/27 Human Book - researcher in cancer: online event about cancer awareness, risk factors and prevention, for the employees of a private company (Balanças Marques) located in Braga - Portugal
Outro
 Human Library - Cancer
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2023/10/11 - 2023/10/12 Lead Today. Shape Tomorrow. is the event where startups, investors & innovation opinion leaders get together to create an inclusive future of entrepreneurship.
Conferência
 Lead Today Shape Tomorrow 2023 (LTST2023)
Female Founders, Áustria
2023/03/30 - 2023/03/30 Human Book - researcher in cancer: round table discussion with high school students about cancer (awareness, risk factors and prevention)
Mesa-redonda
 Human Library - Cancer
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021/04/22 - 2021/04/24 ORPHEUS CONFERENCE 2021: interactive teaching methodologies and valuable tools in postgraduate education (assessment, feedback, entrepreneurship, type of supervision, conflict management).
Conferência
 ORPHEUS CONFERENCE 2021
Universidade do Minho Escola de Medicina, Portugal
2021/02/22 - 2021/02/22 Human Book - researcher in cancer: online round table discussion with high school students about cancer (awareness, risk factors and prevention)
Mesa-redonda
 Human Library - cancer
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2020/10/26 - 2020/10/30 EATRIS: Translational Medicine Explained (TMex) digital course
Oficina (workshop)
 TMex Winter School 2020
European infrastructure for translational medicine, Países Baixos
2020/06/18 - 2020/06/19 EACR 2020 Virtual Congress
Congresso
 EACR 2020 Virtual Congress
European Association For Cancer Research, Reino Unido
2019/03/15 - 2019/03/15 Human Book - researcher in cancer: round table discussion with high school students about cancer (awareness, risk factors and prevention)
Mesa-redonda
 Human Library - Cancer
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2008/02/25 - 2008/02/25 "Let´s do Chemistry" (Vamos Kimikar) - participation on the science outreach activity for 30 high school students of were several laboratory experiments were carried out
Outro
 "Let´s do Chemistry" (Vamos Kimikar)
Universidade do Minho Escola de Ciências, Portugal
2007/06/23 - 2007/06/27 "Live Science in the Laboratory" (Ciência Viva no Laboratório) - supervision of two high-school students during a summer internship in the laboratory, promoting routine lab activities (science outreach activity)
Outro
 "Live Science in the Laboratory" (Ciência Viva no Laboratório)
Universidade do Minho Escola de Ciências, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/07/20 Evaluation of the antiangiogenic effect of polymeric nanoparticles with bevacizumab for colorectal cancer treatment
Arguente principal
 Aline Franciane Leão (Mestrado)
Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Farmacêuticas, Brasil
2022/07/28 Assessing the in vitro Antimicrobial and Antitumor Activity of Portuguese Propolis
Arguente principal
 Rafaela Dias Oliveira (Mestrado)
Universidade do Minho, Portugal

Universidade do Minho Departamento de Biologia, Portugal
2022/01/07 Validation of a novel delivery system towards breast cancer therapy
Arguente principal
 Renata Ferreira da Silva (Mestrado)
Universidade do Minho Departamento de Engenharia Biológica, Portugal
2021/07/29 New chromene derivatives: synthesis and anticancer activity
Orientador
 Diogo Costa (Mestrado)
Universidade do Minho Departamento de Química, Portugal
2021/06/30 Characterization of the anticancer activity of novel compounds for the treatment of renal cell carcinoma
Orientador
 Ana Catarina Machado Pereira (Outro)
Universidade do Minho Departamento de Biologia, Portugal
2021/06/29 Exploitation of chromene-based compounds as PLD1 modulators for TNBC therapy
Orientador
 Ana Carolina Ferreira Martins (Outro)
Universidade do Minho Departamento de Biologia, Portugal
2021/03/31 Exploitation of new chromene-based compounds as promising agents for cancer treatment
Orientador
 Ana Luísa Carvalho (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/01/12 Immunoexpression profile of hypoxia-inducible factor (HIF) targets in premalignant and malignant oral lesions: A pilot study
Arguente principal
 Shakiba Gholami (Mestrado)
Universidade do Minho Departamento de Biologia, Portugal
2019/12/17 Exploring the anticancer effect of new rutheniumbiotinylated conjugates in colorectal cancer
Arguente principal
 Pedro José Pereira Fernandes (Mestrado)
Universidade do Minho Departamento de Biologia, Portugal
2019/11/20 Characterization of the activity of novel chromene derivatives for cancer therapy
Orientador
 Sofia Oliveira-Pinto (Mestrado)
Universidade do Minho, Portugal
2019/07/31 Imagiological techniques for tumor volume estimation in the CAM model: comparative studies
Orientador
 Sara Alexandra Carvalho Lopes de Freitas (Outro)
Universidade do Minho Departamento de Física, Portugal
2019/06/30 Exploitation of new chromenes as promising agents for the treatment of cancer
Orientador
 Beatriz Rocha Ferreira (Outro)
Universidade do Minho Departamento de Biologia, Portugal
2019/03/31 Exploitation of chromenes as promising agents for cancer treatment
Orientador
 Ana Isabel Oliveira (Outro)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2018/11/30 The reaction of salicylaldehyde with activated methylene compounds: product characterization and reactivity studies
Orientador
 Diogo Alexandre Vilaça Lopes (Mestrado)
Universidade do Minho, Portugal
2017/06/30 Exploitation of the biological activity of novel compounds for the treatmento of cancer
Orientador
 Sofia Oliveira-Pinto (Outro)
Universidade do Minho Departamento de Biologia, Portugal
2015/11/30 Reactivity studies on chromene derivatives
Orientador
 João Gomes (Mestrado)
Universidade do Minho, Portugal
2015/07/31 Synthesis of novel chromene derivatives and anticancer evaluation
Orientador
 Madalena Nunes Monteiro (Outro)
Universidade do Minho Departamento de Biologia, Portugal
2013/11/30 Synthesis of chromene derivatives as potential anticancer agents
Orientador
 Ana Alexandra Gonçalves (Mestrado)
Universidade do Minho, Portugal
2013/11/30 Synthesis of novobiocin analogues as potential anticancer agents
Orientador
 Ana Isabel Rodrigues (Mestrado)
Universidade do Minho, Portugal
2013/06/30 Synthesis and reactivity studies of piridinium salts
Orientador
 Jennifer Martins Noro (Outro)
Universidade do Minho Departamento de Química, Portugal
2012/12/18 Synthesis of epigallocatechin-3-gallate derivatives
Arguente principal
 Tatiana Alexandra de Freitas Perdigão Dias (Mestrado)
Universidade do Minho Departamento de Química, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2023/09/22 - Atual 5th National Meeting for Young Researchers in Oncology (ENJIO) Portuguese League Against Cancer (LPCC-NRN)
2022/09/24 - 2022/09/24 4th National Meeting for Young Researchers in Oncology (ENJIO) Portuguese League Against Cancer (LPCC-NRN)
2019/10/17 - 2019/10/19 ISCaM2019 - 6th Annual meeting Braga, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022/10 - 2022/10 Laboratory class "Experimental approaches in Oncobiology: Lab II - Immunohistochemistry method"; part of the "Fundamentals in Genetics, Development and Neoplasia" post-graduation course Master's degrees Health Sciences (School of Medicine) (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2022/10 - 2022/10 Laboratory III: Chick Chorioallantoic Membrane (CAM) assay; part of the "Fundamentals in Genetics, Development and Neoplasia" post-graduation course Master's degrees Health Sciences (School of Medicine) (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2022/10 - 2022/10 The Chick Chorioallantoic Membrane (CAM) assay: principles and applications; part of the "Fundamentals in Genetics, Development and Neoplasia" post-graduation course Master's degrees Health Sciences (School of Medicine) (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2021/10 - 2021/10 Laboratory class "Experimental approaches in Oncobiology: Lab II - Immunohistochemistry method"; part of the "Fundamentals in Genetics, Development and Neoplasia" post-graduation course Master's degrees Health Sciences (School of Medicine) (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2020/10 - 2020/10 Laboratory class "Experimental approaches in Oncobiology: Lab II - Immunohistochemistry method"; part of the "Fundamentals in Genetics, Development and Neoplasia" post-graduation course Master's degrees Health Sciences (School of Medicine) (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2019/10 - 2019/10 Laboratory class "Experimental approaches in Oncobiology: Lab II - Immunohistochemistry method"; part of the "Fundamentals in Genetics, Development and Neoplasia" post-graduation course Master's degrees Health Sciences (School of Medicine) (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2015/02/01 - 2015/07/31 Fundamentals in organic Chemistry, laboratory course for the students of the Degree in Environmental Sciences (1st year) Fundamentals in organic Chemistry (Licence) Universidade do Minho Departamento de Química, Portugal
2014/09/01 - 2015/01/31 Integrated Chemistry Laboratories, laboratory course for the students of the Degree in Biology Engineering (1st year) Integrated Chemistry Laboratories (Licence) Universidade do Minho Departamento de Química, Portugal
2013/09/01 - 2014/01/31 Fundamentals in Organic Chemistry, tutorial course for the students of the Degree in Applied Biology (1st year) Fundamentals in Organic Chemistry (Licence) Universidade do Minho Departamento de Química, Portugal
2013/02/01 - 2013/07/31 Fundamentals in Organic Chemistry, laboratory course for the students of the Degree in Applied Biology (1st year) Fundamentals in Organic Chemistry (Licence) Universidade do Minho Departamento de Química, Portugal
2012/09/01 - 2013/01/31 Fundamentals in Organic Chemistry, laboratory course for the students of the Degree in Biology and Geology (1st year) Fundamentals in Organic Chemistry (Licence) Universidade do Minho Departamento de Química, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2023/12/06 Interview - Bfk Award Sábado (Magazine)
2023/11/21 AIIA award finalist - Interview Sábado (Magazine)
2023/08/03 The scientific development of chromene-based compounds Jornal Expresso

Entrevista / Programa (rádio / tv)

Programa Tema
2024/01/06 - Atual Falar Global New cancer treatment - Bfk award
2023/11/26 - Atual Regional News: Start-up from Braga develops innovative treatment for aggressive cancers
2023/11/15 - Atual Radio Pitch by RFM
2023/11/15 - Atual Innovative startups from the north of Portugal at Web Summit
2023/07/13 - Atual UMinho I&D - Radio interview Karion Therapeutics and the development of a new drug candidate for aggressive cancers
2023/07/08 - Atual Ciência no Feminino (Women in Science) - Radio interview/Podcast Women in science
2023/04/01 - 2023/05/02 Podcast: Science in the Feminine (Ciência no Feminino) Women in science
2021/01/26 - 2021/01/26 Mentes que brilham (Minds that shine) - TV show Novel therapeutic approach for triple negative breast cancer
2020/09/10 - 2020/09/10 UM I&D - Radio interview Ongoing research projects in the University of Minho
2020/08/18 - 2020/08/18 Portugal Em Directo (Portugal Live) - TV show Breast Cancer - novel therapy for triple negative breast cancer subtype

Membro de associação

Nome da associação Tipo de participação
2019/09/01 - Atual Portuguese League Against Cancer - Liga Portuguesa Contra o Cancro Member
2016/02/25 - Atual European Association for Cancer Research (EARC) Member
2016/01 - Atual Portuguese Association for Cancer Research - ASPIC Member
2019 - 2020 International Society of Cancer Metabolism (ISCaM)
2006 - 2011 Organic Chemistry Division of the Portuguese Chemical Society (SPQ)

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2009/10/01 - 2011/04/30 Delegate of the PhD course in Sciences of the School of Sciences, representing PhD students from the Chemistry, Biology, Mathematics, Physics and Geology departments
Outro
 Universidade do Minho Escola de Ciências, Portugal
2010/02/01 - 2010/12/31 Member of the Pedagogical Council of the School of Science of the University of Minho
Membro
 Universidade do Minho - Escola de Ciências, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023/02/13 - 2023/05/01 Graduate Women in Science (GWIS) - National Fellowship Program Reviewer Graduate Women in Science, Estados Unidos
2023/02/01 - 2023/05/01 Admission to the New Path of the Integrated Master in Medicine: member of the evaluation panel Universidade do Minho Escola de Medicina, Portugal
2022/02/01 - 2022/05/03 Graduate Women in Science (GWIS) - National Fellowship Program Reviewer Graduate Women in Science, Estados Unidos
2022/02 - 2022/05 Admission to the New Path of the Integrated Master in Medicine: member of the evaluation panel Universidade do Minho Escola de Medicina, Portugal
2021/02/01 - 2021/05/31 Graduate Women in Science (GWIS) - National Fellowship Program Reviewer Graduate Women in Science, Estados Unidos
2021/02 - 2021/05 Admission to the New Path of the Integrated Master in Medicine: member of the evaluation panel Universidade do Minho Escola de Medicina, Portugal
2020/03/01 - 2020/07/21 Graduate Women in Science (GWIS) - National Fellowship Program Reviewer Graduate Women in Science, Estados Unidos
2020/02 - 2020/05 Admission to the New Path of the Integrated Master in Medicine: member of the evaluation panel Universidade do Minho Escola de Medicina, Portugal
Distinções

Prémio

2023 Arqus International Innovators Award
Arqus European University Alliance, Espanha
2023 BfK Award - Born From Knowledge
Agência Nacional de Inovação SA, Portugal
2022 Innovation Award Bluepharma | University of Coimbra
Bluepharma, Portugal
2022 SpinUM
TecMinho Associação Universidade-Empresa para o Desenvolvimento, Portugal
2022 UI-CAN
UI-CAN - Universities as an Interface for Entrepreneurship, Portugal
2021 V Research Pitches Contest of the Compostela Group of Universities
Compostela Group of Universities (CGU) , Espanha
2019 EACR Poster Prize: 1st place in the 6th Annual ISCaM Meeting, Braga Portugal
European Association For Cancer Research, Reino Unido
2018 EACR-Worldwide Cancer Research Meeting Bursary to attend the 3rd edition of Making it Personal: Cancer Precision Medicine in Centro Congressi Giovanni XXIII, Bergamo, Italy.
European Association For Cancer Research, Reino Unido
2018 Best Poster Communication Award in the ICVS Open Week, School of Medicine, University of Minho, Braga, Portugal.
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 Poster Communication Award (2nd Place) in the 1st Applied Biochemistry Symposium, School of Sciences, University of Minho, Braga, Portugal.
2010 Winter School Bursary - 9th Swiss Course on Medicinal Chemistry
Swiss Chemical Society, Suiça
2006 Merit award of the University of Minho
Universidade do Minho, Portugal
2005 Merit award of the University of Minho
Universidade do Minho, Portugal
2004 Merit award of the University of Minho
Universidade do Minho, Portugal