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Luís Martinho do Rosário. Licenciate/licenciatura in Chemistry (int. photochemistry) by the University of Coimbra (UC), Portugal (1977). Ph.D. in Biophysics by the University of East Anglia, Norwich, UK (1983). Currently: Associate Professor in Biochemistry and Cellular Biophysics at the Department of Life Sciences, Faculty of Sciences and Technology, UC. Formerly: Visiting Fellow/Associate at the National Institutes of Health (NIH), Bethesda, MD, USA (1984-1989); Visiting Scientist at the University of Alicante, Spain (1989-1990). Main research areas: Cellular biophysics and signal transduction, with emphasis in stimulus-secretion coupling. Published over 90 peer-reviewed articles and book chapters in international journals, meeting proceedings and books. Main teaching areas: Cellular biohysics, physical biochemistry, and nutritional biochemistry.
Identificação

Identificação pessoal

Nome completo
Luís Martinho do Rosário

Identificadores de autor

Ciência ID
9414-4074-5700
ORCID iD
0000-0001-8329-2333

Endereços de correio eletrónico

  • lrosario@uc.pt (Profissional)

Telefones

Telefone
  • 304502928 (Profissional)
  • 23924070 (Profissional)
  • 23982019 (Profissional)

Moradas

  • University of Coimbra, Faculty of Sciences and Technology, Department of Life Sciences, Calçada Martim de Freitas, 3000-456, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • https://www.uc.pt/fctuc/dcv/pessoas/docentes/copy_of_novo_docentes (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
1980 - 1983
Concluído
Ph.D. in Biophysics (Doutoramento)
University of East Anglia, Reino Unido
"Electrophysiological and ultra-violet irradiation studies on the pancreatic beta-cells from normal and diabetic genetic background mice. A thesis presented for the degree of Doctor of Philosophy (Unpublished). " (TESE/DISSERTAÇÃO)
Honours
1973 - 1977
Concluído
Licenciate/Licenciatura in Chemistry (internship in photochemistry) (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"[Determination of critical micelle concentrations of synthetic surfactants by surfactant-mediated quenching of uranyl ion fluorescence] A dissertation presented for the Licenciate degree in Chemistry at the Dept. of Chemistry, FCT, UC (pp.1-81)." (TESE/DISSERTAÇÃO)
17 em 20 / 17 in 20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
1989/01 - 1990/07 Investigador (Investigação) Universitat d'Alacant, Espanha
1972/01 - 1973/12 Investigador (Investigação) Universidade de Coimbra, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
1999/09 - Atual Professor Associado (Docente Universitário) Universidade de Coimbra, Portugal
1992/09 - 1999/08 Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
1990/08 - 1992/08 Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
1981/01 - 1985/02 Assistente (Docente Universitário) Universidade de Coimbra, Portugal
1978/01 - 1980/12 Assistente Estagiário (Docente Universitário) Universidade de Coimbra, Portugal
1977/09 - 1977/12 Assistente Estagiário (Docente Universitário) Universidade da Beira Interior, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
1987/01 - 1988/12 Visiting Associate (Investigação Científica) National Institutes of Health, Estados Unidos
1984/01 - 1986/12 Visiting Fellow (Investigação Científica) National Institutes of Health, Estados Unidos
1980/09 - 1983/12 Doutorando (Investigação Científica) University of East Anglia, Reino Unido
Produções

Publicações

Artigo em conferência
  1. AR Ribeiro; CM Antunes; L Rosário; MH Gil. "Immobilization of firefly luciferase on glass strips as an alternative strategy for luminescent detection of ATP". Trabalho apresentado em Symposium on Bioluminescence Assays for Industry, Cambridge, UK, 1997.
    Publicado
Artigo em revista
  1. Rosário, Luís. "ROS changes evoked by the natural sweetener Rebaudioside A in a neuronal system". Energy Reports (2019): http://dx.doi.org/10.1016/j.egyr.2019.09.067.
    10.1016/j.egyr.2019.09.067
  2. Rosário, Luís. "Sulfamethoxazole induces zinc changes at hippocampal mossy fiber synapses from pregnant rats.". Gen Physiol Biophys (2018): http://europepmc.org/abstract/med/29593127.
    10.4149/gpb_2017037
  3. Quinta-Ferreira, M. E.; Sampaio dos Aidos, F. D. S.; Matias, C. M.; Mendes, P. J.; Dionísio, J. C.; Santos, R. M.; Rosário, L. M.; Quinta-Ferreira, R. M.. "Modelling zinc changes at the hippocampal mossy fiber synaptic cleft". Journal of Computational Neuroscience 41 3 (2016): 323-337.
    Publicado • 10.1007/s10827-016-0620-x
  4. Rosário, Luís; LM Rosário; RM Barbosa; CM Antunes; IE Baldeiras; AM Silva; AR Tomé; RM Santos. "Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in absence of functional K(ATP) channels.". Endocr J 55 4 (2008): 639-650. http://europepmc.org/abstract/med/18493109.
    Publicado • 10.1507/endocrj.k07e-131
  5. AM Silva; RJ Rodrigues; AR Tomé; RA Cunha; S Misler; LM Rosário; RM Santos. "Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic beta cells [Web of Science Citações jul2014: 11]". PANCREAS 36 3 (2008): 279-283. https://dl.dropboxusercontent.com/u/78717758/DeGois2/Silva%20et%20al.%20(2008).pdf.
    Publicado • 10.1097/MPA.0b013e31815a8473
  6. AR Tomé; E Castro; RM Santos; LM Rosário. "Functional distribution of Ca2+-coupled P2 purinergic receptors among adrenergic and noradrenergic bovine adrenal chromaffin cells". BMC Neuroscience 8 1 (2007): 39-39. http://www.biomedcentral.com/1471-2202/8/39.
    Publicado • 10.1186/1471-2202-8-39
  7. AR Tomé; E Castro; RM Santos; LM Rosário. "Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP". BMC Neuroscience 8 1 (2007): 41-41. http://www.biomedcentral.com/1471-2202/8/41.
    Publicado • 10.1186/1471-2202-8-41
  8. IE Baldeiras; RM Santos; LM Rosário. "Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/insulin release from mouse pancreatic islets [Web of Science Citações jul2014: 2]". BIOLOGICAL RESEARCH 39 3 (2006): 531-539. http://europepmc.org/abstract/med/17106584.
    Publicado • 10.4067/S0716-97602006000300014
  9. Rosário, Luís. "Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/ insulin release from mouse pancreatic islets.". Biol Res (2006): http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300014&lng=en&nrm=iso&tlng=en.
    S0716-97602006000300014
  10. RM Seiça; KI Suzuki; RM Santos; LM Rosário. "[Impaired insulin secretion in isolated islets of Goto-Kakizaki rats, an animal model of non obese type 2 diabetes, is a primary event] [Web of Science Citações jul2014: 16]". Acta Medica Portuguesa 17 1 (2004): 42-48. http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1755/1332.
    Publicado
  11. Rosário, Luís. "[Impaired insulin secretion in isolated islets of Goto-Kakizaki rats, an animal model of non obese type 2 diabetes, is a primary event]". Acta Medica Port (2004): http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1755/1332.
  12. RM Seiça; MJ Martins; PB Pessa; RM Santos; LM Rosário; KI Suzuki; MI Martins. "[Morphological changes of islet of Langerhans in an animal model of type 2 diabetes] [Web of Science Citações jul2014: 11]". Acta Medica Portuguesa 16 6 (2003): 381-388. http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1223/875.
    Publicado
  13. Rosário, Luís. "[Morphological changes of islet of Langerhans in an animal model of type 2 diabetes].". Acta Medica Port (2003): http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1223/875.
  14. AR Tomé; V Izaguirre; LM Rosário; V Ceña; C González-García. "Naloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cells". Brain Research 903 1-2 (2001): 62-65. https://dl.dropboxusercontent.com/u/78717758/DeGois2/Tom%C3%A9%20et%20al.%20(2001).pdf.
    Publicado • 10.1016/S0006-8993(01)02388-5
  15. CM Sena; RM Santos; NB Standen; MR Boarder; LM Rosário. "Isoform-specific inhibition of voltage-sensitive Ca2+ channels by protein kinase C in adrenal chromaffin cells". FEBS LETTERS 492 1-2 (2001): 146-150. http://www.ncbi.nlm.nih.gov/pubmed/11248253.
    Publicado • 10.1016/S0014-5793(01)02252-9
  16. FC Pereira; R Ouedraogo; P Lebrun; RM Barbosa; AP Cunha; RM Santos; LM Rosário. "Insulinotropic action of white lupine seeds (Lupinus albus L.): Effects on ion fluxes and insulin secretion from isolated pancreatic islets [Web of Science Citações jul2014: 6]". BIOMEDICAL RESEARCH-TOKYO 22 2 (2001): 103-109. https://dl.dropboxusercontent.com/u/78717758/DeGois2/Pereira2001_Biomed.Res._Insulinotropic%20action.pdf.
    Publicado
  17. LM Rosário. "Insulinotropic action of white lupine seeds (Lupinus albus L.): Effects on ion fluxes and insulin secretion from isolated pancreatic islets". Biomed Res - Tokyo (2001): https://www.jstage.jst.go.jp/article/biomedres/22/2/22_103/_article.
    10.2220/biomedres.22.103
  18. CM Antunes; AP Salgado; LM Rosário; RM Santos. "Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets". DIABETES 49 12 (2000): 2028-2038. http://www.ncbi.nlm.nih.gov/pubmed/11118004.
    Publicado • 10.2337/diabetes.49.12.2028
  19. AP Salgado; RM Santos; AP Fernandes; AR Tomé; PR Flatt; LM Rosário. "Glucose-mediated Ca2+ signalling in single clonal insulin-secreting cells: evidence for a mixed model of cellular activation". International Journal of Biochemistry & Cell Biology 32 5 (2000): 557-569. https://dl.dropboxusercontent.com/u/78717758/DeGois2/Salgado%20et%20al.%20(2000).pdf.
    Publicado • 10.1016/S1357-2725(99)00146-6
  20. AP Salgado; FC Pereira; RM Seiça; AP Fernandes; PR Flatt; RM Santos; LM Rosário; R Ramasamy. "Modulation of glucose-induced insulin secretion by cytosolic redox state in clonal ß-cells". Molecular and Cellular Endocrinology 154 1-2 (1999): 79-88. https://dl.dropboxusercontent.com/u/78717758/DeGois2/Salgado%20et%20al.%20(1999).pdf.
    Publicado • 10.1016/S0303-7207(99)00085-4
  21. CM Sena; RM Santos; MR Boarder; LM Rosário. "Regulation of Ca2+ influx by a protein kinase C activator in chromaffin cells: differential role of P/Q- and L-type Ca2+ channels". European Journal of Pharmacology 366 2-3 (1999): 281-292. https://dl.dropboxusercontent.com/u/78717758/DeGois2/Sena%20et%20al.%20(1999).pdf.
    Publicado • 10.1016/S0014-2999(98)00908-X
  22. RM Barbosa; AM Silva; AR Tomé; JA Stamford; RM Santos; LM Rosário. "Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics". JOURNAL OF PHYSIOLOGY-LONDON 510 1 (1998): 135-143. http://www.ncbi.nlm.nih.gov/pubmed/9625872.
    Publicado • 10.1111/j.1469-7793.1998.135bz.x
  23. MJ Oset-Gasque; S Vicente; MP González; LM Rosário; E Castro. "Segregation of nitric oxide synthase expression and calcium response to nitric oxide in adrenergic and noradrenergic bovine chromaffin cells". Neuroscience 83 1 (1998): 271-280. https://dl.dropboxusercontent.com/u/78717758/DeGois2/Oset-Gasque%20et%20al.%20(1998).pdf.
    Publicado • 10.1016/S0306-4522(97)00377-1
  24. AR Ribeiro; RM Santos; LM Rosário; MH Gil. "Immobilization of luciferase from a firefly lantern extract on glass strips as an alternative strategy for luminescent detection of ATP". LUMINESCENCE 13 6 (1998): 371-378. http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1099-1271(199811/12)13:6%3C371::AID-BIO510%3E3.0.CO;2-%23/pdf.
    Publicado • 10.1002/(SICI)1099-1271(199811/12)13:6<371::AID-BIO510>3.0.CO;2-#
  25. RM Santos; Barbosa RM; CM Antunes; AM Silva; AP Salgado; AJ Abrunhosa; FC Pereira; RM Seiça; LM Rosário. "Bursting electrical activity generated in the presence of K-ATP channel blockers". Advances in Experimental Medicine and Biology 426 II (1997): 33-41. http://europepmc.org/abstract/med/9544253.
    Publicado • 10.1007/978-1-4899-1819-2_5
  26. Barbosa RM; Silva AM; Tomé AR; Stamford JA; Santos RM; Rosário LM. "Real time electrochemical detection of 5-HT/insulin secretion from single pancreatic islets: effect of glucose and K+ depolarization". Biochemical and Biophysical Research Communications 228 1 (1996): 100-104. http://www.sciencedirect.com/science/article/pii/S0006291X96916228.
    Publicado • 10.1006/bbrc.1996.1622
  27. RM Barbosa; LM Rosário; CMA Brett; AMO Brett. "Electrochemical studies of zinc in zinc-insulin solution". Analyst 121 12 (1996): 1789-1793. http://europepmc.org/abstract/MED/9008404.
    Publicado • 10.1039/an9962101789
  28. CM Sena; LM Rosário; PJ Parker; V Patel; MR Boarder. "Differential regulation of histamine- and bradykinin-stimulated phospholipase C in adrenal chromaffin cells: Evidence for involvement of different protein kinase C isoforms". JOURNAL OF NEUROCHEMISTRY 66 3 (1996): 1086-1094. http://www.ncbi.nlm.nih.gov/pubmed/8769870.
    Publicado • 10.1046/j.1471-4159.1996.66031086.x
  29. AP Salgado; AM Silva; RM Santos; LM Rosário. "Multiphasic action of glucose and alpha-ketoisocaproic acid on the cytosolic pH of pancreatic beta-cells - Evidence for an acidification pathway linked to the stimulation of Ca2+ influx". JOURNAL OF BIOLOGICAL CHEMISTRY 271 15 (1996): 8738-8746. http://www.ncbi.nlm.nih.gov/pubmed/8621508.
    Publicado • 10.1074/jbc.271.15.8738
  30. E Castro; JS Mateo; AR Tomé; RM Barbosa; MT Miras-Portugal; LM Rosário. "Cell-specific purinergic receptors coupled to Ca2+ entry and Ca2+ release from internal stores in adrenal chromaffin cells -differential sensitivity to UTP and suramin". JOURNAL OF BIOLOGICAL CHEMISTRY 270 10 (1995): 5098-5106. http://www.ncbi.nlm.nih.gov/pubmed/7890618.
    Publicado • 10.1074/jbc.270.10.5098
  31. MR Boarder; CM Sena; PJ Parker; V Patel; LM Rosário. "REGULATION OF BRADYKININ RESPONSES BY PKC-EPSILON AND HISTAMINE RESPONSES BY PKC-ALPHA IN ADRENAL CHROMAFFIN CELLS". BIOCHEMICAL SOCIETY TRANSACTIONS 23 3 (1995): S424-S424. http://www.ncbi.nlm.nih.gov/pubmed/8566312.
    Publicado • 10.1042/bst023424s
  32. CM Sena; AR Tomé; RM Santos; LM Rosário. "Protein kinase C activator inhibits voltage-sensitive Ca2+ channels and catecholamine secretion in adrenal chromaffin cells". FEBS LETTERS 359 2-3 (1995): 137-141. http://www.sciencedirect.com/science/article/pii/0014579395000266.
    Publicado • 10.1016/0014-5793(95)00026-6
  33. Rosário, Luís. "Background Ca2+ influx mediated by a dihydropyridine- and voltage-insensitive channel in pancreatic beta-cells. Modulation by Ni2+, diphenylamine-2-carboxylate, and glucose metabolism.". J Biol Chem (1994): http://europepmc.org/abstract/med/8006014.
  34. AM Silva; LM Rosário; RM Santos. "BACKGROUND CA2+ INFLUX MEDIATED BY A DIHYDROPYRIDINE-INSENSITIVE AND VOLTAGE-INSENSITIVE CHANNEL IN PANCREATIC BETA-CELLS - MODULATION BY NI2+, DIPHENYLAMINE-2-CARBOXYLATE, AND GLUCOSE-METABOLISM". JOURNAL OF BIOLOGICAL CHEMISTRY 269 25 (1994): 17095-17103. http://europepmc.org/abstract/med/8006014.
    Publicado
  35. E Castro; AR Tomé; MT Miras-Portugal; LM Rosário. "Single-cell fura-2 microfluorometry reveals different purinoceptor subtypes coupled to Ca2+ influx and intracellular Ca2+ release in bovine adrenal chromaffin and endothelial cells". Pflugers Archiv-European Journal of Physiology 426 6 (1994): 524-533. http://link.springer.com/article/10.1007/BF00378530.
    Publicado • 10.1007/BF00378530
  36. RM Barbosa; AP Salgado; RM Santos; LM Rosário. "Differential modulation of pancreatic ß-cell bursting by intracellular pH in the presence and absence of a K-ATP channel blocker". FEBS LETTERS 332 1-2 (1993): 9-13. http://www.sciencedirect.com/science/article/pii/0014579393804716.
    Publicado • 10.1016/0014-5793(93)80471-6
  37. CB Duarte; LM Rosário; CM Sena; AP Carvalho. "A toxin fraction (FTX) from the funnel-web spider poison inhibits dihydropyridine-insensitive Ca2+ channels coupled to catecholamine release in bovine adrenal chromaffin cells". Journal of Neurochemistry 60 3 (1993): 908-913. http://www.ncbi.nlm.nih.gov/pubmed/8382265.
    Publicado • 10.1111/j.1471-4159.1993.tb03236.x
  38. LM Rosário; RM Barbosa; CM Antunes; AM Silva; AJ Abrunhosa; RM Santos. "Bursting electrical activity in pancreatic beta-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels". Pflugers Archiv-European Journal of Physiology 424 5-6 (1993): 439-447. http://www.ncbi.nlm.nih.gov/pubmed/7504808.
    Publicado • 10.1007/BF00374906
  39. CB Duarte; AR Tomé; E Forsberg; CAM Carvalho; AP Carvalho; RM Santos; LM Rosário. "Neomycin blocks dihydropyridine-insensitive Ca2+ influx in bovine adrenal chromaffin cells". EUROPEAN JOURNAL OF PHARMACOLOGY 244 3 (1993): 259-267. http://www.ncbi.nlm.nih.gov/pubmed/8458400.
    Publicado • 10.1016/0922-4106(93)90151-X
  40. RM Santos; RM Barbosa; AM Silva; CM Antunes; LM Rosário. "High external Ca2+ levels trigger membrane potential oscillations in mouse pancreatic ß-cells during blockade of K(ATP) channels". BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 187 2 (1992): 872-879. http://www.ncbi.nlm.nih.gov/pubmed/1530642.
    Publicado • 10.1016/0006-291X(92)91278-X
  41. RM Santos; LM Rosário; A Nadal; J Garcia-Sancho; B Soria; M Valdeolmillos. "Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets". Pflugers Archiv-European Journal of Physiology 418 4 (1991): 417-422. http://www.ncbi.nlm.nih.gov/pubmed/1876486.
    Publicado • 10.1007/BF00550880
  42. A Ramu; N Ramu; LM Rosário. "Circumvention of multidrug-resistance in P388 cells is associated with a rise in the cellular content of phosphatidylcholine". Biochemical Pharmacology 41 10 (1991): 1455-1461. http://www.ncbi.nlm.nih.gov/pubmed/2018553.
    Publicado • 10.1016/0006-2952(91)90561-I
  43. LM Rosário; A Stutzin; EJ Cragoe; HB Pollard. "Modulation of intracellular pH by secretagogues and the Na+/H+ antiporter in cultured bovine chromaffin cells". NEUROSCIENCE 41 1 (1991): 269-276. http://www.ncbi.nlm.nih.gov/pubmed/1647503.
    Publicado • 10.1016/0306-4522(91)90215-A
  44. Rosário, Luís. "Role of intracellular pH in secretion from adrenal medulla chromaffin cells.". J Biol Chem (1989): http://europepmc.org/abstract/med/2910860.
  45. A Ramu; HB Pollard; LM Rosário. "Doxorubicin resistance in P388 leukemia—evidence for reduced drug influx". INTERNATIONAL JOURNAL OF CANCER 44 3 (1989): 539-547. http://www.ncbi.nlm.nih.gov/pubmed/2777417.
    Publicado • 10.1002/ijc.2910440328
  46. GA Kuijpers; LM Rosário; RL Ornberg. "ROLE OF INTRACELLULAR PH IN SECRETION FROM ADRENAL-MEDULLA CHROMAFFIN CELLS". JOURNAL OF BIOLOGICAL CHEMISTRY 264 2 (1989): 698-705. http://europepmc.org/abstract/med/2910860.
    Publicado
  47. M Valdeolmillos; RM Santos; D Contreras; B Soria; LM Rosário. "Glucose-induced oscillations of intracellular Ca2+ concentration resembling bursting electrical activity in single mouse islets of Langerhans". FEBS LETTERS 259 1 (1989): 19-23. http://www.sciencedirect.com/science/article/pii/001457938981484X.
    Publicado • 10.1016/0014-5793(89)81484-X
  48. LM Rosário; B Soria; G Feuerstein; HB Pollard. "Voltage-sensitive calcium flux into bovine chromaffin cells occurs through dihydropyridine-sensitive and dihydropyridine- and omega-conotoxin-insensitive pathways". NEUROSCIENCE 29 3 (1989): 735-747. http://www.ncbi.nlm.nih.gov/pubmed/2739907.
    Publicado • 10.1016/0306-4522(89)90145-0
  49. Rosário, Luís. "Potassium channel selectivity in mouse pancreatic B cells.". Am J Physiol Cell Physiol (1986): http://europepmc.org/abstract/med/2417495.
    10.1152/ajpcell.1986.250.1.C90
  50. LM Rosário; E Rojas. "POTASSIUM CHANNEL SELECTIVITY IN MOUSE PANCREATIC B-CELLS". AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 250 1 (1986): C90-C94. http://europepmc.org/abstract/med/2417495.
    Publicado
  51. LM Rosário. "Electrophysiological measurements show marked differences in the properties of the pancreatic beta-cell K-channels from albino mice and a strain of ob/ob (obese) mice". Advances in Experimental Medicine and Biology 211 - (1986): 95-107. http://europepmc.org/abstract/med/2440255.
    Publicado • 10.1007/978-1-4684-5314-0_9
  52. LM Rosário; E Rojas. "Modulation of K+ conductance by intracellular pH in pancreatic ß-cells". FEBS LETTERS 200 1 (1986): 203-209. http://www.sciencedirect.com/science/article/pii/0014579386805397.
    Publicado • 10.1016/0014-5793(86)80539-7
  53. LM Rosário; I Atwater; AM Scott. "Pulsatile insulin release and electrical activity from single ob/ob mouse islets of Langerhans". Advances in Experimental Medicine and Biology 211 - (1986): 413-425. http://europepmc.org/abstract/med/3300197.
    Publicado • 10.1007/978-1-4684-5314-0_40
  54. Rosário, Luís. "Membrane potential measurements in islets of Langerhans from ob/ob obese mice suggest an alteration in [Ca2+]i-activated K+ permeability.". Exp Physiol (1985): http://europepmc.org/abstract/med/3925492.
    10.1113/expphysiol.1985.sp002885
  55. LM Rosário. "Differential effects of the K+ channel blockers apamin and quinine on glucose-induced electrical activity in pancreatic ß-cells from a strain of ob/ob (obese) mice". FEBS LETTERS 188 2 (1985): 302-306. http://www.sciencedirect.com/science/article/pii/0014579385803914.
    Publicado • 10.1016/0014-5793(85)80391-4
  56. LM Rosário; I Atwater; E Rojas. "MEMBRANE-POTENTIAL MEASUREMENTS IN ISLETS OF LANGERHANS FROM OB/OB OBESE MICE SUGGEST AN ALTERATION IN [CA2+]I-ACTIVATED K+ PERMEABILITY". EXPERIMENTAL PHYSIOLOGY 70 1 (1985): 137-150. http://ep.physoc.org/content/70/1/137.long.
    Publicado
  57. P Lebrun; I Atwater; LM Rosário; A Herchuelz; WJ Malaisse. "Dissociation by methylamine of insulin release from glucose-induced electrical activity in isolated mouse islets of Langerhans". METABOLISM-CLINICAL AND EXPERIMENTAL 34 12 (1985): 1122-1127. http://www.ncbi.nlm.nih.gov/pubmed/3906352.
    Publicado • 10.1016/0026-0495(85)90157-X
  58. I Atwater; LM Rosário; E Rojas. "Properties of the Ca-activated K+ channel in pancreatic beta-cells". CELL CALCIUM 4 5-6 (1983): 451-461. http://europepmc.org/abstract/MED/6323007.
    Publicado • 10.1016/0143-4160(83)90021-0
  59. SJ Formosinho; LM Rosário. "Determinação de concentrações micelares críticas por supressão da luminescência do ião uranilo excitado". Revista Portuguesa de Química 20 1 (1978): 88-95.
    Publicado
Artigo em revista (magazine)
  1. LM Rosário. "A fábrica celular de insulina", Colóquio / Ciências, 2014, https://dl.dropboxusercontent.com/u/78717758/DeGois/Rosario1994_ColCi%C3%AAn_A%20f%C3%A1brica.pdf.
Capítulo de livro
  1. AP Salgado; RM Santos; FC Pereira; AP Fernandes; AR Tomé; PR Flatt; R Ramasamy; LM Rosário. "Glucose signalling in clonal insulin-secreting BRIN-BD11 cells: Role of cytosolic Ca2+ and redox state". In Molecular mechanisms of transcellular signaling: From membrane receptors to transcription factors, 212-220. The Netherlands: IOS Press, 1999.
    Publicado
  2. RM Santos; RM Barbosa; AM Silva; CM Antunes; LM Rosário. "[Ca2+]i-sensitive conductance in the regulation of pancreatic beta-cell bursting". In Insulin secretion and pancreatic B-cell research, 181-186. USA, Portugal: Smith-Gordon, 1994.
    Publicado
Resumo em conferência
  1. JI Real; HA Figueiredo; AM Silva; RM Barbosa; RM Santos; LM Rosário. "Actions of the BK channel blocker charybdotoxin on glucose-induced electrical activity in whole mouse islets". Trabalho apresentado em 46th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon, PORTUGAL, 2011.
    Publicado • 10.1007/s00125-011-2276-4
  2. AM Silva; LM Rosário; RM Santos. "Modulation of glucose-induced 5-HT/insulin release by metabotropic purinergic receptors". Trabalho apresentado em XVIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society, Coimbra, PORTUGAL, 2005.
    Publicado
  3. LM Rosário; RM Barbosa; CM Antunes; IE Baldeiras; AM Silva; RM Santos. "Metabolic regulation of oscillatory electrical activity and 5-HT/insulin release from single pancreatic islets in the absence of functional K-ATP channels". Trabalho apresentado em XVIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society, Coimbra, PORTUGAL, 2005.
    Publicado
  4. LM Rosário. "Oscillatory islet activity in the absence of functional K-ATP channels: A new paradigm for assessment of amplification mechanisms". Trabalho apresentado em Research Symposium on Islet Biology, Falmouth, MA, USA, 2002.
    Publicado
  5. LM Rosário; RM Barbosa; CM Antunes; IE Baldeiras; AM Silva; AMP Silva; RM Santos. "Metabolic regulation of oscillatory islet activity in the absence of functional K-ATP channels: A possible approach to correction of beta-cell dysfunction in PHHI?". Trabalho apresentado em EASD Islet Study Group Meeting, Glasgow, UK, 2001.
    Publicado
  6. CM Sena; RM Santos; NB Standen; MR Boarder; LM Rosário. "Specific inhibition of voltage-sensitive Ca2+ channels by protein kinase C epsilom isoform in bovine adrenal chromaffin cells". Trabalho apresentado em 3rd European Biophysics Congress, Munchen, GERMANY, 2000.
    Publicado
  7. IE Baldeiras; RM Barbosa; RM Santos; LM Rosário. "Involvement of protein kinase C in cholinergic potentiation of glucose-induced 5-HT/insulin secretion". Trabalho apresentado em 17th International Diabetes Federation Congress, Mexico City, MEXICO, 2000.
    Publicado
  8. IE Baldeiras; RM Barbosa; AR Tomé; RM Santos; LM Rosário. "Modulation of glucose-induced 5-HT/insulin oscillations by phorbol ester and cholinergic activation of protein kinase C in single pancreatic islets". Trabalho apresentado em IV Congreso Iberoamericano de Biofísica, Sociedad de Biofísicos Latinoamericanos (SOBLA), Alicante, SPAIN, 2000.
    Publicado
  9. CM Antunes; AP Salgado; RM Santos; LM Rosário. "Evidence for reduced sensitivity to glucose of electrical activity from diabetic GK islets". Trabalho apresentado em V Congreso Iberoamericano de Biofísica, Sociedad de Biofísicos Latinoamericanos (SOBLA), Alicante, SPAIN, 2000.
    Publicado
  10. IE Baldeiras; RM Barbosa; RM Santos; LM Rosário. "Modulation of glucose-induced 5-HT/insulin secretion by protein kinase C activation in single mouse pancreatic islets". Trabalho apresentado em Islet Research European Network (IREN) Workshop, Geneva, SWITZERLAND, 2000.
    Publicado
  11. IE Baldeiras; RM Barbosa; RM Santos; LM Rosário. "Evidence that PKC activation enhances pre-exocytotic steps in gucose-induced HT/insulin secretion from single mouse pancreatic islets". Trabalho apresentado em 39th Annual Meeting of the American Societry for Cell Biology, Washington, DC, USA, 1999.
    Publicado
  12. CM Sena; RM Barbosa; RM Santos; NB Slanden; MR Boarder; LM Rosário. "Modulation of voltage-sensitive Ca2+ channels and catecholamine release by PKC in adrenal chromaffin cells". Trabalho apresentado em 43rd Annual Meeting of the Biophysical Society, Baltimore, MD, USA, 1999.
    Publicado
  13. AR Tomé; E Castro; MT Miras-Portugal; LM Rosário. "Functional distribution of P2 purinoceptor subtypes in adrenal medulla chromaffin cells". Trabalho apresentado em 43rd Annual Meeting of the Biophysical Society, Baltimore, MD, USA, 1999.
    Publicado
  14. CM Antunes; AP Salgado; LM Rosário; RM Santos. "Differential pattern of glucose-induced electrical activity and intracellular calcium rises in rat and mouse islets". Trabalho apresentado em 34th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, SPAIN, 1998.
    Publicado
  15. IE Baldeiras; RM Barbosa; RM Santos; JA Stamford; AMO Brett; CMA Brett; LM Rosário. "Electrochemical detection of 5-HT/insulin secretion from single pancreatic islets". Trabalho apresentado em 7th European Conference on ElectroAnalysis (ESEAC'98) of the European Society for ElectroAnalytical Chemistry, Coimbra, PORTUGAL, 1998.
    Publicado
  16. LM Rosário; AM Silva; CM Antunes; AR Tomé; RM Santos; RM Barbosa. "Glucose- and sulphonylurea-evoked pulsatile insulin release from single islets as detected by 5-HT microamperometry". Trabalho apresentado em 16th Congress of the International Diabetes Federation (IDF), Helsinki, FINLAND, 1997.
    Publicado
  17. RM Santos; RM Seiça; AP Salgado; FC Pereira; CM Antunes; KI Suzuki; LM Rosário. "Dissociation between cytosolic Ca2+ and insulin responses in glucose-stimulated islets from diabetic GK rats". Trabalho apresentado em 16th Congress of the International Diabetes Federation (IDF), Helsinki, FiINLAND, 1997.
    Publicado
  18. AP Salgado; AP Fernandes; FC Pereira; RM Seiça; PR Flatt; RM Santos; LM Rosário; R Ramasamy. "Modulation of glucose-induced insulin-secretion by cytosolic redox state in BRIN-BD11 cells". Trabalho apresentado em 16th Congress of the International Diabetes Federation (IDF), Helsinki, FINLAND, 1997.
    Publicado
  19. AP Salgado; AP Fernandes; FC Pereira; AR Tomé; MC Catalão; PR Flatt; RM Santos; LM Rosário; R Ramasamy. "Stimulus-secretion coupling in a glucose-sensitive insulinoma: role of cytosolic Ca2+ and redox state". Trabalho apresentado em Sixth Workshop of the Islet Research European Network (IREN): Function and Dysfunction of Pancreatic Islet Cells and Insulin Secretory Cell Lines, Coleraine,Northern Ireland, UK, 1997.
    Publicado
  20. AP Salgado; AM Silva; RM Santos; LM Rosário. "Multiphasic action of glucose and alpha-ketoisocaproic acid on the cytosolic pH of pancreatic beta-cells: Evidence for an acidification pathway linked to the stimulation of Ca2+ influx". Trabalho apresentado em 40th Annual Meeting of the Biophysical Society, Baltimore, MD, USA, 1996.
    Publicado
  21. AP Salgado; RM Santos; AR Tomé; AP Fernandes; PR Flatt; LM Rosário. "Glucose-mediated Ca2+ signalling in the novel insulin secreting cell line BRIN-D11". Trabalho apresentado em 32nd Annual Meeting of the European Association of the Study of Diabetes (EASD), Vienna, AUSTRIA, 1996.
    Publicado
  22. RM Barbosa; AM Silva; JA Stamford; RM Santos; LM Rosário. "Real-time simultaneous monitoring of insulin (5-HT) secretion and cytosolic Ca2+ from single islets of Langerhans". Trabalho apresentado em 32nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Vienna, AUSTRIA, 1996.
    Publicado
  23. RM Santos; CM Antunes; AM Silva; LM Rosário; RM Barbosa. "Bursting electrical activity of pancreatic beta-cells in the absence of functional K-ATP channels: Modulation by glucose metabolism". Trabalho apresentado em 40th Annual Meeting of the Biophysical Society, Baltimore, MD, USA, 1996.
    Publicado
  24. LM Rosário; E Castro; MT Miras-Portugal; RM Barbosa; JA Stamford; AR Tomé; J Mateo. "Purinergic receptor expression and function in adrenal chromaffin cells: a single cell approach". Trabalho apresentado em 40th Annual Meeting of the Biophysical Society, Baltimore, MD, USA, 1996.
    Publicado
  25. CM Sena; LM Rosário; PJ Parker; V Patel; MR Boarder. "Histamine and bradykinin stimulations of calcium transients are controlled by different protein kinase C isoforms". Trabalho apresentado em Meeting of the British Pharmacological Society, Kent, UK, 1995.
    Publicado
  26. FC Pereira; R Ouedraogo; RM Seiça; AM Silva; RM Barbosa; AP Cunha; RM Santos; P Lebrun; LM Rosário. "Insulinotropic and Ca2+ mobilizing actions of a lupine seed extract on isolated rodent islets". Trabalho apresentado em 31st Annual Meeting of the European Association for the Study of Diabetes (EASD), Stockholm, SWEDEN, 1995.
    Publicado
  27. MJ Oset-Gasque; E Castro; MP González; LM Rosário. "Differential functional response of adrenergic and noradrenergic bovine cromaffin cells to GABA and nitric oxide". Trabalho apresentado em 15th Biennial Meeting of the International Society for Neurochemistry, Kyoto, JAPAN, 1995.
    Publicado
  28. E Castro; AR Tomé; J Mateo; RM Barbosa; LM Rosário; MT Miras-Portugal. "Differential expression of P-2-purinoceptor subtypes in adrenomedullary cells". Trabalho apresentado em N/A, N/A, 1995.
    Publicado
  29. AP Salgado; RM Santos; LM Rosário. "Modulation of cytosolic pH by fuel secretagogues in pancreatic beta-cells". Trabalho apresentado em 1st Portuguese-Spanish Biophysics Congress, Lisbon, PORTUGAL, 1995.
    Publicado
  30. RM Barbosa; CM Antunes; AM Silva; RM Santos; LM Rosário. "Metabolic enhancement of pancreatic beta-cell bursting electrical activity in the absence of functional ATP-sensitive K+ channels". Trabalho apresentado em 1st Portuguese-Spanish Biophysics Congress, Lisbon, PORTUGAL, 1995.
    Publicado
  31. RM Santos; C Vozzi; AP Salgado; A Charollais; AG Carmo; LM Rosário; P Meda. "Enhanced responsiveness to glyceraldehyde of RIN cells transfected with the connexin-43 gene". Trabalho apresentado em 30th Annual Meeting of the European Association for the Study of Diabetes (EASD), Dusseldorf, GERMANY, 1994.
    Publicado
  32. AM Silva; RM Barbosa; RM Santos; LM Rosário. "Background Ca2+ influx mediated by a Ni2+- and DPC-sensitive channel in pancreatic beta-cells". Trabalho apresentado em 30th Annual Meeting of the European Association for the Study of Diabetes (EASD), Dusseldorf, GERMANY, 1994.
    Publicado
  33. AP Salgado; RM Santos; LM Rosário. "Multiphasic action of glucose on the cytosolic pH of beta-cells: evidence for two opposing mechanisms". Trabalho apresentado em 30th Annual Meeting of the European Association for the Study of Diabetes (EASD), Dusseldorf, GERMANY, 1994.
    Publicado
  34. E Castro; AR Tomé; J Mateo; MT Miras-Portugal; LM Rosário. "Purinoceptor-mediated Ca2+ entry mechanisms into adrenomedullary cells". Trabalho apresentado em 5th International Symposium on Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, Philadelphia, PA, USA, 1994.
    Publicado
  35. AM Silva; LM Rosário; RM Santos. "[Ca2+]i measurements from single islets: Evidence for a novel Ca2+ influx pathway". Trabalho apresentado em 29th Annual Meeting of the European Association for the Study of Diabetes (EASD), Istanbul, TURKEY, 1993.
    Publicado
  36. LM Rosário; RM Barbosa; CM Antunes; AM Silva; RM Santos. "[Ca2+]i-sensitive conductance in the regulation of pancreatic beta-cell bursting". Trabalho apresentado em 29th Annual Meeting of the European Association for the Study of Diabetes (EASD), Istanbul, TURKEY, 1993.
    Publicado
  37. LM Rosário; RM Barbosa; AM Silva; CM Antunes; RM Santos. "Enhanced Ca2+ influx hyperpolarizes the beta-cell membrane by inactivating a Ca2+ conductance". Trabalho apresentado em 28th Annual Meeting of the European Association for the Study of Diabetes (EASD), Prague, CZECHOSLOVAKIA, 1992.
    Publicado
  38. LM Rosário; E Forsberg; CAM Carvalho; CB Duarte. "The aminoglycoside antibiotic neomycin blocks dihydropyridine-insensitive Ca2+ channels in bovine adrenal medulla chromaffin cells". Trabalho apresentado em Joint Meeting of the American Society for Biochemistry and Molecular Biology and the Biophysical Society, Houston, TX, USA, 1992.
    Publicado
  39. LM Rosário; RM Santos; D Contreras; B Soria; M Valdeolmillos. "Glucose-induced oscillations of intracellular Ca2+ and membrane potential in single mouse islets of langerhans". Trabalho apresentado em 34th Annual Meeting of the Biophysical Society, Baltimore, MD, USA, 1990.
    Publicado
  40. RM Santos; LM Rosário; D Contreras; A Nadal; J Garcia-Sancho; B Soria; M Valdeolmillos. "Synchronous intracellular calcium oscillations due to bursting electrical activity in single islets of Langerhans". Trabalho apresentado em 26th Annual Meeting of the European Association for the Study of Diabetes (EASD), Copenhagen, DENMARK, 1990.
    Publicado
  41. Rosário, Luís M.. "Modulation of intracellular free calcium levels by the sulfonylurea tolbutamide in single islets of Langerhans". Trabalho apresentado em 26th Annual Meeting of the European Association for the Study of Diabetes (EASD), Copenhagen, DENMARK, 1990.
    Publicado
  42. CB Duarte; LM Rosário. "Does K+ depolarization induce Ca2+ mobilization from internal stores in chromaffin cells?". Trabalho apresentado em 12th Meeting of the International Society for Neurochemistry, Algarve, PORTUGAL, 1989.
    Publicado
  43. LM Rosário; B Soria; HB Pollard. "Evidence that calcium ions enter chromaffin cells through a voltage-dependent pathway which is insensitive to dihydropyridines and omega-conotoxin". Trabalho apresentado em 32nd Annual Meeting of the Biophysical Society, Phoenix, AZ, USA, 1988.
    Publicado
  44. GAJ Kuijpers; LM Rosário; RL Ornberg. "Effect of NH4Cl on intracellular pH and catecholamine secretion by adrenal chromaffin cells". Trabalho apresentado em 27th Annual Meeting of the American Society for Cell Biology, St. Louis, MO, USA, 1987.
    Publicado
  45. LM Rosário; I Atwater; E Rojas. "Ammonium chloride increases cytoplasmic pH, activates K+ permeability, and inhibits glucose-induced electrical activity and insulin release in single mouse islets of Langerhans". Trabalho apresentado em 30th Annual Meeting of the Biophysical Society, San Francisco, CA, USA, 1986.
    Publicado
  46. E Rojas; I Atwater; LM Rosário. "Effects of cytosolic pH changes on glucose-induced electrical activity in mouse pancreatic beta-cells". Trabalho apresentado em 12th Congress of the International Diabetes Federation, Madrid, SPAIN, 1985.
    Publicado
  47. LM Rosário; I Atwater; E Rojas. "Electrophysiological measurements show marked differences in the properties of the K+ channels from ob/ob and albino mouse pancreatic beta-cells". Trabalho apresentado em 12th Congress of the International Diabetes Federation, Madrid, SPAIN, 1985.
    Publicado
  48. Rosário, Luís. "1997 | Modulation of glucose-induced insulin-secretion by cytosolic redox state in BRIN-BD11 cells". 1913.
    doi.org/10.1007/BF03162081
  49. Rosário, Luís. "2000 | Involvement of protein kinase C in cholinergic potentiation of glucose-induced 5-HT/insulin secretion". 1913.
    10.1016/S0168-8227(00)81965-8
  50. Rosário, Luís. "1996 | Bursting electrical activity of pancreatic beta-cells in the absence of functional K-ATP channels: Modulation by glucose metabolism". 1913.
    10.1016/S0006-3495(96)79667-4
  51. Rosário, Luís. "1988 | Evidence that calcium ions enter chromaffin cells through a voltage-dependent pathway which is insensitive to dihydropyridines and omega-conotoxin". 1913.

Outros

Outra produção
  1. Electrophysiological and ultra-violet irradiation studies on the pancreatic beta-cells from normal and diabetic genetic background mice. 1983. LM Rosário.
  2. Determinação de concentrações micelares críticas por supressão da luminescência do ião uranilo excitado por surfactantes. Tese de licenciatura na área de Fotoquímica, sob a orientação do Prof. S.J. Formosinho. 1977. LM Rosário.
  3. Apontamentos de Química Inorgânica. Apoio ao estudo de Química Inorgânica, leccionada pelo Prof. V. Gil. 1972. LM Rosário.
Distinções

Prémio

1984 Postdoctoral Visiting Fellow award for collaborative biomedical research at the NIH, 1984-1986
1980 Doctoral fellowship for study and research at the University of East Anglia
Fundação Calouste Gulbenkian, Portugal

Outra distinção

1987 Appointment as Visiting Associate for collaborative biomedical research at the NIH, 1987-1989
National Institutes of Health, Estados Unidos
1971 Prémio D. Dinis
Sociedade Central de Cervejas, Portugal