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Identificação

Identificação pessoal

Nome completo
Clementina Maria Moreira dos Santos

Nomes de citação

  • Santos, Clementina

Identificadores de autor

Ciência ID
9018-DB9C-C590
ORCID iD
0000-0003-4380-7990
Scopus Author Id
7201458663

Endereços de correio eletrónico

  • clems@ipb.pt (Profissional)

Telefones

Telefone
  • 273303308 (Profissional)

Moradas

  • Instituto Politécnico de Bragança, 5300-253, Bragança, Bragança, Portugal (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês
Formação
Grau Classificação
2007
Concluído
 Química (Doutoramento)
Especialização em Não Aplicável
Universidade de Aveiro, Portugal
1996
Concluído
 Química, ramo Alimentar (Licenciatura)
Especialização em Não Aplicável
Universidade de Aveiro, Portugal
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2000/09 - Atual Professor Adjunto (Docente Ensino Superior Politécnico) Instituto Politécnico de Bragança, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/02 - Atual Membro Comissão Científica Mestrado em Engenharia Biotecnológica Instituto Politécnico de Bragança, Portugal
Instituto Politécnico de Bragança, Portugal
2013 - 2021 Conselho pedagógico Instituto Politécnico de Bragança, Portugal
Projetos

Projeto

Designação Financiadores
2019/12/01 - 2022/11/30 Desenvolvimento de novos inibidores do osteossarcoma invasivo baseados em derivados da fisetina
PTDC/MED-QUI/29243/2017
Universidade de Aveiro, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/16 - 2021/07/15 Novos compostos heterocíclicos de nitrogénio e oxigénio C-glicosilados como potenciais agentes anticancerígenos com ação epigenética imunoestimuladora
PTDC/QUI-QOR/29767/2017
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2005/09/01 - 2008/06/30 Síntese de cromonas e avaliação, in vitro, das suas propriedades antioxidantes e anti-inflamatórias
POCI/QUI/59284/2004
REQUIMTE LAQV Porto, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Albuquerque, Hélio M. T.; Nunes da Silva, Raquel; Pereira, Marisa; Maia, André; Guieu, Samuel; Soares, Ana Raquel; Santos, Clementina M. M.; Vieira, Sandra I.; Silva, Artur M. S.. "Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes". ACS Medicinal Chemistry Letters 13 3 (2022): 443-448. http://dx.doi.org/10.1021/acsmedchemlett.1c00604.
    10.1021/acsmedchemlett.1c00604
  2. Santos, Clementina M. M.; Proença, Carina; Freitas, Marisa; Araújo, Alberto N.; Silva, Artur M. S.; Fernandes, Eduarda. "Inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by hydroxylated xanthones". Food & Function 13 14 (2022): 7930-7941. http://dx.doi.org/10.1039/d2fo00023g.
    10.1039/d2fo00023g
  3. Santos, Clementina M. M.; Silva, Artur M. S.. "The Antioxidant Activity of Prenylflavonoids". Molecules 25 3 (2020): 696. http://dx.doi.org/10.3390/molecules25030696.
    10.3390/molecules25030696
  4. Rocha, Sónia; Sousa, Adelaide; Ribeiro, Daniela; Correia, Catarina M.; Silva, Vera L. M.; Santos, Clementina M. M.; Silva, Artur M. S.; et al. "A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by chalcone derivatives". Food & Function 10 9 (2019): 5510-5520. http://dx.doi.org/10.1039/c9fo01298b.
    10.1039/c9fo01298b
  5. Hélio M. T. Albuquerque; Clementina Santos; Artur M. S. Silva. "Cholesterol-Based Compounds: Recent Advances in Synthesis and Applications". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/116.
    10.3390/molecules24010116
  6. Clementina M.M. Santos; Marisa Freitas; Eduarda Fernandes. "A comprehensive review on xanthone derivatives as a-glucosidase inhibitors". European Journal of Medicinal Chemistry 157 (2018): 1460-1479. https://doi.org/10.1016/j.ejmech.2018.07.073.
    10.1016/j.ejmech.2018.07.073
  7. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. "First intramolecular Diels–Alder reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones". New Journal of Chemistry (2018): https://doi.org/10.1039/C7NJ05185A.
    10.1039/C7NJ05185A
  8. Hélio M. T. Albuquerque; Clementina M. M. Santos; Mannix P. Balanay; José A. S. Cavaleiro; Artur M. S. Silva. "1,6-Conjugate Additions of Carbon Nucleophiles to 2-[(1E ,3E )-4-Arylbuta-1,3-dien-1-yl]-4H -chromen-4-ones". European Journal of Organic Chemistry 2017 35 (2017): 5293-5305. https://doi.org/10.1002/ejoc.201700944.
    10.1002/ejoc.201700944
  9. Clementina M. M. Santos; Artur M. S. Silva. "An Overview of 2-Styrylchromones: Natural Occurrence, Synthesis, Reactivity and Biological Properties". European Journal of Organic Chemistry 2017 22 (2017): 3115-3133. https://doi.org/10.1002/ejoc.201700003.
    10.1002/ejoc.201700003
  10. Hélio M. T. Albuquerque; Clementina M. M. Santos; Carlos F. R. A. C. Lima; Luís M. N. B. F. Santos; José A. S. Cavaleiro; Artur M. S. Silva. "2-[(1E ,3E )-4-Arylbuta-1,3-dien-1-yl]-4H -chromen-4-ones as Dienes in Diels-Alder Reactions - Experimental and Computational Studies". European Journal of Organic Chemistry 2017 1 (2017): 87-101. https://doi.org/10.1002/ejoc.201601072.
    10.1002/ejoc.201601072
  11. Santos, C.M.M.; Ribeiro, D.; Silva, A.M.S.; Fernandes, E.. "2,3-Diarylxanthones as potential inhibitors of arachidonic acid metabolic pathways". Inflammation 40 3 (2017): 956-964. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021641003&partnerID=MN8TOARS.
    10.1007/s10753-017-0540-6
  12. Santos, C.M.M.; Silva, V.L.M.; Silva, A.M.S.. "Synthesis of chromone-related pyrazole compounds". Molecules 22 10 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85032920137&partnerID=MN8TOARS.
    10.3390/molecules22101665
  13. Proença, C.; Albuquerque, H.M.T.; Ribeiro, D.; Freitas, M.; Santos, C.M.M.; Silva, A.M.S.; Fernandes, E.. "Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities". European Journal of Medicinal Chemistry 115 (2016): 381-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961962762&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.03.043
  14. Santos, C.M.M.; Pinto, D.C.G.A.; Silva, V.L.M.; Silva, A.M.S.. "Arylxanthones and arylacridones: A synthetic overview". Pure and Applied Chemistry 88 6 (2016): 579-594. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983343546&partnerID=MN8TOARS.
    10.1515/pac-2016-0407
  15. Silva, E.M.P.; Barros, C.M.R.F.; Santos, C.M.M.; Barros, A.S.; Domingues, M.R.M.; Silva, A.M.S.. "Characterization of 2,3-diarylxanthones by electrospray mass spectrometry: gas-phase chemistry versus known antioxidant activity properties". Rapid Communications in Mass Spectrometry (2016): 2228-2236. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987786778&partnerID=MN8TOARS.
    10.1002/rcm.7697
  16. Gomes, A.; Capela, J.P.; Ribeiro, D.; Freitas, M.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; et al. "Inhibition of NF-kB Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones". Medicinal Chemistry 11 6 (2015): 560-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938564231&partnerID=MN8TOARS.
  17. Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "(E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as Synthons for the Synthesis of Xanthone-1,2,3-triazole Dyads". European Journal of Organic Chemistry 2015 21 (2015): 4732-4743. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027941784&partnerID=MN8TOARS.
    10.1002/ejoc.201500448
  18. Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocycles". Current Organic Chemistry 18 21 (2014): 2750-2775. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925949986&partnerID=MN8TOARS.
  19. Tomé, S.M.; Silva, A.M.S.; Santos, C.M.M.. "Synthesis and transformation of halochromones". Current Organic Synthesis 11 3 (2014): 317-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904094471&partnerID=MN8TOARS.
    10.2174/15701794113109990063
  20. Santos, C.M.M.; Silva, A.M.S.. "Six-membered ring systems. With O and/or S atoms.". Progress in Heterocyclic Chemistry 25 (2013): 406-453. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883515756&partnerID=MN8TOARS.
    10.1016/B978-0-08-099406-2.00016-9
  21. Santos, C.M.M.; Garcia, M.B.Q.; Silva, A.M.S.; Santus, R.; Morlière, P.; Fernandes, E.. "Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry". Tetrahedron Letters 54 1 (2013): 85-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870292315&partnerID=MN8TOARS.
    10.1016/j.tetlet.2012.10.103
  22. Santos, C.M.M.; Silva, A.M.S.. "Six-Membered Ring Systems: With O and/or S Atoms". Progress in Heterocyclic Chemistry 24 (2012): 443-492. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866498013&partnerID=MN8TOARS.
    10.1016/B978-0-08-096807-0.00015-4
  23. Patoilo, D.T.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; Tomé, A.C.; Cavaleiro, J.A.S.. "Tetrahydroquinazoline-substituted chromones from Diels-Alder reaction of (E)-2-styrylchromones and pyrimidine ortho-quinodimethane". Tetrahedron Letters 53 22 (2012): 2722-2725. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860224943&partnerID=MN8TOARS.
    10.1016/j.tetlet.2012.03.081
  24. Santos, C.M.M.; Silva, A.M.S.; Jeko, J.; Lévai, A.. "Synthesis and structure elucidation of novel pyrazolyl-2-pyrazolines obtained by the reaction of 3-(3-aryl-3-oxopropenyl)chromen-4-ones with phenylhydrazine". Arkivoc 2012 5 (2012): 265-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867862528&partnerID=MN8TOARS.
    10.3998/ark.5550190.0013.522
  25. Morlière, P.; Patterson, L.K.; Santos, C.M.M.; Silva, A.M.S.; Mazière, J.-C.; Filipe, P.; Gomes, A.; et al. "The dependence of a-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment". Organic and Biomolecular Chemistry 10 10 (2012): 2068-2076. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857527197&partnerID=MN8TOARS.
    10.1039/c2ob06612b
  26. Santos, C.M.M.; Silva, A.M.S.; Filipe, P.; Santus, R.; Patterson, L.K.; Mazière, J.-C.; Cavaleiro, J.A.S.; Morlière, P.. "Structure-activity relationships in hydroxy-2,3-diarylxanthone antioxidants. Fast kinetics spectroscopy as a tool to evaluate the potential for antioxidant activity in biological systems". Organic and Biomolecular Chemistry 9 10 (2011): 3965-3974. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955369637&partnerID=MN8TOARS.
    10.1039/c0ob00841a
  27. Esteves, C.I.C.; Santos, C.M.M.; Brito, C.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "Synthesis of novel 1-aryl-9 H -xanthen-9-ones". Synlett 10 (2011): 1403-1406. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958159886&partnerID=MN8TOARS.
    10.1055/s-0030-1260567
  28. Santos, C.M.M.; Freitas, M.; Ribeiro, D.; Gomes, A.; Silva, A.M.S.; Cavaleiro, J.A.S.; Fernandes, E.. "2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure-activity relationship study". Bioorganic and Medicinal Chemistry 18 18 (2010): 6776-6784. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956342859&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.07.044
  29. Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "Efficient syntheses of new polyhydroxylated 2,3-diaryl-9H-xanthen-9-ones". European Journal of Organic Chemistry 16 (2009): 2642-2660. http://www.scopus.com/inward/record.url?eid=2-s2.0-66249089826&partnerID=MN8TOARS.
    10.1002/ejoc.200900026
  30. Lvai, A.; Silva, A.M.S.; Santos, C.M.M.; Cavaleiro, J.A.S.; Jek, J.. "Dimethyldioxirane oxidation of exocyclic (E,E)-cinnamylideneketones". Australian Journal of Chemistry 62 1 (2009): 82-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-59049091454&partnerID=MN8TOARS.
    10.1071/CH08216
  31. Gomes, A.; Fernandes, E.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; Cavaleiro, J.A.S.; Lima, J.L.F.C.. "Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways". Biochemical Pharmacology 78 2 (2009): 171-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349237764&partnerID=MN8TOARS.
    10.1016/j.bcp.2009.03.028
  32. Gomes, A.; Fernandes, E.; Garcia, M.B.Q.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; Cavaleiro, J.A.S.; Lima, J.L.F.C.. "Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity". Bioorganic and Medicinal Chemistry 16 17 (2008): 7939-7943. http://www.scopus.com/inward/record.url?eid=2-s2.0-50349102813&partnerID=MN8TOARS.
    10.1016/j.bmc.2008.07.072
  33. Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "A novel and efficient route for the synthesis of hydroxylated 2,3-diarylxanthones". Synlett 20 (2007): 3113-3116. http://www.scopus.com/inward/record.url?eid=2-s2.0-37749014302&partnerID=MN8TOARS.
    10.1055/s-2007-990900
  34. Gomes, A.; Fernandes, E.; Silva, A.M.S.; Santos, C.M.M.; Pinto, D.C.G.A.; Cavaleiro, J.A.S.; Lima, J.L.F.C.. "2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species". Bioorganic and Medicinal Chemistry 15 18 (2007): 6027-6036. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447648382&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.06.046
  35. Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.; Lévai, A.; Patonay, T.. "Epoxidation of (E,E)-cinnamylideneacetophenones with hydrogen peroxide and iodosylbenzene with salen-MnIII as the catalyst". European Journal of Organic Chemistry 17 (2007): 2877-2887. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250795648&partnerID=MN8TOARS.
    10.1002/ejoc.200700123
  36. Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.; Patonay, T.; Lévai, A.. "Epoxidation studies of 2-styrylchromones using Jacobsen's catalyst and hydrogen peroxide and iodosylbenzene as oxidants". Journal of Heterocyclic Chemistry 43 5 (2006): 1319-1326. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750959213&partnerID=MN8TOARS.
    10.1002/jhet.5570430526
  37. Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "New synthesis of 2,3-diarylxanthones". Synlett 20 (2005): 3095-3098. http://www.scopus.com/inward/record.url?eid=2-s2.0-29744458203&partnerID=MN8TOARS.
    10.1055/s-2005-921928
  38. Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "Synthesis of New Hydroxy-2-styrylchromones". European Journal of Organic Chemistry 23 (2003): 4575-4585. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345168773&partnerID=MN8TOARS.
  39. Fernandes, E.; Carvalho, M.; Carvalho, F.; Silva, A.M.S.; Santos, C.M.M.; Pinto, D.C.G.A.; Cavaleiro, J.A.S.; Maria, D.L.B.. "Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes". Archives of Toxicology 77 9 (2003): 500-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141889904&partnerID=MN8TOARS.
    10.1007/s00204-003-0480-9
  40. Fernandes, E.; Carvalho, F.; Silva, A.M.S.; Santos, C.M.M.; Pinto, D.C.G.A.; Cavaleiro, J.A.S.; Bastos, M.D.L.. "2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study". Journal of Enzyme Inhibition and Medicinal Chemistry 17 1 (2002): 45-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036336276&partnerID=MN8TOARS.
    10.1080/14756360290019944
Capítulo de livro
  1. Santos, Clementina M.M.; Silva, Artur M.S.. "Eight-Membered Rings With One Oxygen Atom". In Comprehensive Heterocyclic Chemistry IV, 44-84. Elsevier, 2022.
    10.1016/b978-0-12-409547-2.14816-4
  2. Albuquerque, Hélio M.T.; Santos, Clementina M.M.; Silva, Artur M.S.. "Cholesterol chemistry and laboratory synthesis". In Cholesterol, 3-24. Elsevier, 2022.
    10.1016/b978-0-323-85857-1.00007-9
  3. Santos, Clementina M.M.; Silva, Artur M.S.. "Recent advances in the synthesis of 4H-chromen-4-ones (2012 - 2021)". In Advances in Heterocyclic Chemistry, 159-241. Elsevier, 2022.
    10.1016/bs.aihch.2022.02.001
  4. Silva, V. L. M.; Pinto, D. C. G. A.; dos Santos, C. M. M.; Rocha, D. H. A.. "15.4.5 Quinolinones and Related Systems (Update 2022)". In Knowledge Updates 2022/3. Georg Thieme Verlag KG, 2022.
    10.1055/sos-sd-115-01218
  5. Santos, Clementina M.M.; Silva, Artur M.S.. "Six-membered ring systems: with O and/or S atoms". In Progress in Heterocyclic Chemistry, 501-563. Elsevier, 2021.
    10.1016/b978-0-323-89812-6.00015-8
  6. Santos, Clementina M.M.; Silva, Artur M.S.. "Six-membered ring systems: with O and/or S atoms". In Progress in Heterocyclic Chemistry, 473-532. Elsevier, 2021.
    10.1016/b978-0-323-98410-2.00015-1
Livro
  1. Santos, C.M.M.; Silva, A.M.S.. Six-Membered Ring Systems: With O and/or S Atoms. 2016.
    10.1016/B978-0-08-100755-6.00015-6
  2. Santos, C.M.M.; Silva, A.M.S.. Six-Membered Ring Systems: With O and/or S Atoms. 2015.
    10.1016/B978-0-08-100024-3.00015-5
  3. Santos, C.M.M.; Silva, A.M.S.. Nuclear magnetic resonance spectroscopy for structural characterization of bioactive compounds. 2014.
    10.1016/B978-0-444-63359-0.00007-0
  4. Santos, C.M.M.; Silva, A.M.S.. Six-membered ring systems: With O and/or S atoms. 2014.
    10.1016/B978-0-08-100017-5.00015-7
Tese / Dissertação
  1. Albuquerque, Hélio Miguel Teixeira. "Reações de cicloadição e adição conjugada de cromonas substituídas em C.2 com sistemas insaturados". Doutoramento, 2017. http://hdl.handle.net/10773/22220.
  2. Santos, Clementina Maria Moreira dos. "Transformações de cetonas a,ß- e a,ß,¿s- insaturadas : novas rotas de síntese de 2,3- diarilxantonas". Doutoramento, 2007. http://hdl.handle.net/10773/3180.
  3. Santos, Clementina Maria Moreira dos. "Síntese e avaliação da actividade antioxidante de 2-estirilcromonas". Mestrado, 2000. http://hdl.handle.net/10773/26090.