Artigo em revista |
- Albuquerque, Hélio M. T.; Nunes da Silva, Raquel; Pereira, Marisa; Maia, André; Guieu, Samuel; Soares, Ana Raquel; Santos,
Clementina M. M.; Vieira, Sandra I.; Silva, Artur M. S.. "Steroid–Quinoline Hybrids for Disruption and Reversion of Protein
Aggregation Processes". ACS Medicinal Chemistry Letters 13 3 (2022): 443-448. http://dx.doi.org/10.1021/acsmedchemlett.1c00604.
10.1021/acsmedchemlett.1c00604
- Santos, Clementina M. M.; Proença, Carina; Freitas, Marisa; Araújo, Alberto N.; Silva, Artur M. S.; Fernandes, Eduarda. "Inhibition
of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by hydroxylated xanthones". Food & Function
13 14 (2022): 7930-7941. http://dx.doi.org/10.1039/d2fo00023g.
10.1039/d2fo00023g
- Santos, Clementina M. M.; Silva, Artur M. S.. "The Antioxidant Activity of Prenylflavonoids". Molecules 25 3 (2020):
696. http://dx.doi.org/10.3390/molecules25030696.
10.3390/molecules25030696
- Rocha, Sónia; Sousa, Adelaide; Ribeiro, Daniela; Correia, Catarina M.; Silva, Vera L. M.; Santos, Clementina M. M.; Silva,
Artur M. S.; et al. "A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the
carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by chalcone derivatives". Food & Function 10 9 (2019):
5510-5520. http://dx.doi.org/10.1039/c9fo01298b.
10.1039/c9fo01298b
- Hélio M. T. Albuquerque; Clementina Santos; Artur M. S. Silva. "Cholesterol-Based Compounds: Recent Advances in Synthesis
and Applications". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/116.
10.3390/molecules24010116
- Clementina M.M. Santos; Marisa Freitas; Eduarda Fernandes. "A comprehensive review on xanthone derivatives as a-glucosidase
inhibitors". European Journal of Medicinal Chemistry 157 (2018): 1460-1479. https://doi.org/10.1016/j.ejmech.2018.07.073.
10.1016/j.ejmech.2018.07.073
- Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. "First intramolecular Diels–Alder
reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones". New Journal
of Chemistry (2018): https://doi.org/10.1039/C7NJ05185A.
10.1039/C7NJ05185A
- Hélio M. T. Albuquerque; Clementina M. M. Santos; Mannix P. Balanay; José A. S. Cavaleiro; Artur M. S. Silva. "1,6-Conjugate
Additions of Carbon Nucleophiles to 2-[(1E ,3E )-4-Arylbuta-1,3-dien-1-yl]-4H -chromen-4-ones". European Journal of Organic
Chemistry 2017 35 (2017): 5293-5305. https://doi.org/10.1002/ejoc.201700944.
10.1002/ejoc.201700944
- Clementina M. M. Santos; Artur M. S. Silva. "An Overview of 2-Styrylchromones: Natural Occurrence, Synthesis, Reactivity and
Biological Properties". European Journal of Organic Chemistry 2017 22 (2017): 3115-3133. https://doi.org/10.1002/ejoc.201700003.
10.1002/ejoc.201700003
- Hélio M. T. Albuquerque; Clementina M. M. Santos; Carlos F. R. A. C. Lima; Luís M. N. B. F. Santos; José A. S. Cavaleiro;
Artur M. S. Silva. "2-[(1E ,3E )-4-Arylbuta-1,3-dien-1-yl]-4H -chromen-4-ones as Dienes in Diels-Alder Reactions - Experimental
and Computational Studies". European Journal of Organic Chemistry 2017 1 (2017): 87-101. https://doi.org/10.1002/ejoc.201601072.
10.1002/ejoc.201601072
- Santos, C.M.M.; Ribeiro, D.; Silva, A.M.S.; Fernandes, E.. "2,3-Diarylxanthones as potential inhibitors of arachidonic acid
metabolic pathways". Inflammation 40 3 (2017): 956-964. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021641003&partnerID=MN8TOARS.
10.1007/s10753-017-0540-6
- Santos, C.M.M.; Silva, V.L.M.; Silva, A.M.S.. "Synthesis of chromone-related pyrazole compounds". Molecules 22 10 (2017):
http://www.scopus.com/inward/record.url?eid=2-s2.0-85032920137&partnerID=MN8TOARS.
10.3390/molecules22101665
- Proença, C.; Albuquerque, H.M.T.; Ribeiro, D.; Freitas, M.; Santos, C.M.M.; Silva, A.M.S.; Fernandes, E.. "Novel chromone
and xanthone derivatives: Synthesis and ROS/RNS scavenging activities". European Journal of Medicinal Chemistry 115
(2016): 381-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961962762&partnerID=MN8TOARS.
10.1016/j.ejmech.2016.03.043
- Santos, C.M.M.; Pinto, D.C.G.A.; Silva, V.L.M.; Silva, A.M.S.. "Arylxanthones and arylacridones: A synthetic overview". Pure
and Applied Chemistry 88 6 (2016): 579-594. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983343546&partnerID=MN8TOARS.
10.1515/pac-2016-0407
- Silva, E.M.P.; Barros, C.M.R.F.; Santos, C.M.M.; Barros, A.S.; Domingues, M.R.M.; Silva, A.M.S.. "Characterization of 2,3-diarylxanthones
by electrospray mass spectrometry: gas-phase chemistry versus known antioxidant activity properties". Rapid Communications
in Mass Spectrometry (2016): 2228-2236. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987786778&partnerID=MN8TOARS.
10.1002/rcm.7697
- Gomes, A.; Capela, J.P.; Ribeiro, D.; Freitas, M.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; et al. "Inhibition of NF-kB
Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones". Medicinal Chemistry 11 6 (2015): 560-566.
http://www.scopus.com/inward/record.url?eid=2-s2.0-84938564231&partnerID=MN8TOARS.
- Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "(E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as Synthons
for the Synthesis of Xanthone-1,2,3-triazole Dyads". European Journal of Organic Chemistry 2015 21 (2015): 4732-4743.
http://www.scopus.com/inward/record.url?eid=2-s2.0-85027941784&partnerID=MN8TOARS.
10.1002/ejoc.201500448
- Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "Chalcones as versatile synthons for the synthesis
of 5- and 6-membered nitrogen heterocycles". Current Organic Chemistry 18 21 (2014): 2750-2775. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925949986&partnerID=MN8TOARS.
- Tomé, S.M.; Silva, A.M.S.; Santos, C.M.M.. "Synthesis and transformation of halochromones". Current Organic Synthesis
11 3 (2014): 317-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904094471&partnerID=MN8TOARS.
10.2174/15701794113109990063
- Santos, C.M.M.; Silva, A.M.S.. "Six-membered ring systems. With O and/or S atoms.". Progress in Heterocyclic Chemistry
25 (2013): 406-453. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883515756&partnerID=MN8TOARS.
10.1016/B978-0-08-099406-2.00016-9
- Santos, C.M.M.; Garcia, M.B.Q.; Silva, A.M.S.; Santus, R.; Morlière, P.; Fernandes, E.. "Electrochemical characterization
of bioactive hydroxyxanthones by cyclic voltammetry". Tetrahedron Letters 54 1 (2013): 85-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870292315&partnerID=MN8TOARS.
10.1016/j.tetlet.2012.10.103
- Santos, C.M.M.; Silva, A.M.S.. "Six-Membered Ring Systems: With O and/or S Atoms". Progress in Heterocyclic Chemistry
24 (2012): 443-492. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866498013&partnerID=MN8TOARS.
10.1016/B978-0-08-096807-0.00015-4
- Patoilo, D.T.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; Tomé, A.C.; Cavaleiro, J.A.S.. "Tetrahydroquinazoline-substituted
chromones from Diels-Alder reaction of (E)-2-styrylchromones and pyrimidine ortho-quinodimethane". Tetrahedron Letters
53 22 (2012): 2722-2725. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860224943&partnerID=MN8TOARS.
10.1016/j.tetlet.2012.03.081
- Santos, C.M.M.; Silva, A.M.S.; Jeko, J.; Lévai, A.. "Synthesis and structure elucidation of novel pyrazolyl-2-pyrazolines
obtained by the reaction of 3-(3-aryl-3-oxopropenyl)chromen-4-ones with phenylhydrazine". Arkivoc 2012 5 (2012): 265-281.
http://www.scopus.com/inward/record.url?eid=2-s2.0-84867862528&partnerID=MN8TOARS.
10.3998/ark.5550190.0013.522
- Morlière, P.; Patterson, L.K.; Santos, C.M.M.; Silva, A.M.S.; Mazière, J.-C.; Filipe, P.; Gomes, A.; et al. "The dependence
of a-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment". Organic and Biomolecular
Chemistry 10 10 (2012): 2068-2076. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857527197&partnerID=MN8TOARS.
10.1039/c2ob06612b
- Santos, C.M.M.; Silva, A.M.S.; Filipe, P.; Santus, R.; Patterson, L.K.; Mazière, J.-C.; Cavaleiro, J.A.S.; Morlière, P.. "Structure-activity
relationships in hydroxy-2,3-diarylxanthone antioxidants. Fast kinetics spectroscopy as a tool to evaluate the potential for
antioxidant activity in biological systems". Organic and Biomolecular Chemistry 9 10 (2011): 3965-3974. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955369637&partnerID=MN8TOARS.
10.1039/c0ob00841a
- Esteves, C.I.C.; Santos, C.M.M.; Brito, C.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "Synthesis of novel 1-aryl-9 H -xanthen-9-ones".
Synlett 10 (2011): 1403-1406. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958159886&partnerID=MN8TOARS.
10.1055/s-0030-1260567
- Santos, C.M.M.; Freitas, M.; Ribeiro, D.; Gomes, A.; Silva, A.M.S.; Cavaleiro, J.A.S.; Fernandes, E.. "2,3-Diarylxanthones
as strong scavengers of reactive oxygen and nitrogen species: A structure-activity relationship study". Bioorganic and
Medicinal Chemistry 18 18 (2010): 6776-6784. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956342859&partnerID=MN8TOARS.
10.1016/j.bmc.2010.07.044
- Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "Efficient syntheses of new polyhydroxylated 2,3-diaryl-9H-xanthen-9-ones".
European Journal of Organic Chemistry 16 (2009): 2642-2660. http://www.scopus.com/inward/record.url?eid=2-s2.0-66249089826&partnerID=MN8TOARS.
10.1002/ejoc.200900026
- Lvai, A.; Silva, A.M.S.; Santos, C.M.M.; Cavaleiro, J.A.S.; Jek, J.. "Dimethyldioxirane oxidation of exocyclic (E,E)-cinnamylideneketones".
Australian Journal of Chemistry 62 1 (2009): 82-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-59049091454&partnerID=MN8TOARS.
10.1071/CH08216
- Gomes, A.; Fernandes, E.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; Cavaleiro, J.A.S.; Lima, J.L.F.C.. "Anti-inflammatory
potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways". Biochemical Pharmacology
78 2 (2009): 171-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349237764&partnerID=MN8TOARS.
10.1016/j.bcp.2009.03.028
- Gomes, A.; Fernandes, E.; Garcia, M.B.Q.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; Cavaleiro, J.A.S.; Lima, J.L.F.C..
"Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity". Bioorganic and Medicinal
Chemistry 16 17 (2008): 7939-7943. http://www.scopus.com/inward/record.url?eid=2-s2.0-50349102813&partnerID=MN8TOARS.
10.1016/j.bmc.2008.07.072
- Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "A novel and efficient route for the synthesis of hydroxylated 2,3-diarylxanthones".
Synlett 20 (2007): 3113-3116. http://www.scopus.com/inward/record.url?eid=2-s2.0-37749014302&partnerID=MN8TOARS.
10.1055/s-2007-990900
- Gomes, A.; Fernandes, E.; Silva, A.M.S.; Santos, C.M.M.; Pinto, D.C.G.A.; Cavaleiro, J.A.S.; Lima, J.L.F.C.. "2-Styrylchromones:
Novel strong scavengers of reactive oxygen and nitrogen species". Bioorganic and Medicinal Chemistry 15 18 (2007):
6027-6036. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447648382&partnerID=MN8TOARS.
10.1016/j.bmc.2007.06.046
- Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.; Lévai, A.; Patonay, T.. "Epoxidation of (E,E)-cinnamylideneacetophenones
with hydrogen peroxide and iodosylbenzene with salen-MnIII as the catalyst". European Journal of Organic Chemistry
17 (2007): 2877-2887. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250795648&partnerID=MN8TOARS.
10.1002/ejoc.200700123
- Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.; Patonay, T.; Lévai, A.. "Epoxidation studies of 2-styrylchromones using
Jacobsen's catalyst and hydrogen peroxide and iodosylbenzene as oxidants". Journal of Heterocyclic Chemistry 43 5 (2006):
1319-1326. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750959213&partnerID=MN8TOARS.
10.1002/jhet.5570430526
- Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "New synthesis of 2,3-diarylxanthones". Synlett 20 (2005): 3095-3098.
http://www.scopus.com/inward/record.url?eid=2-s2.0-29744458203&partnerID=MN8TOARS.
10.1055/s-2005-921928
- Santos, C.M.M.; Silva, A.M.S.; Cavaleiro, J.A.S.. "Synthesis of New Hydroxy-2-styrylchromones". European Journal of Organic
Chemistry 23 (2003): 4575-4585. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345168773&partnerID=MN8TOARS.
- Fernandes, E.; Carvalho, M.; Carvalho, F.; Silva, A.M.S.; Santos, C.M.M.; Pinto, D.C.G.A.; Cavaleiro, J.A.S.; Maria, D.L.B..
"Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly
isolated rat hepatocytes". Archives of Toxicology 77 9 (2003): 500-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141889904&partnerID=MN8TOARS.
10.1007/s00204-003-0480-9
- Fernandes, E.; Carvalho, F.; Silva, A.M.S.; Santos, C.M.M.; Pinto, D.C.G.A.; Cavaleiro, J.A.S.; Bastos, M.D.L.. "2-Styrylchromones
as novel inhibitors of xanthine oxidase. A structure-activity study". Journal of Enzyme Inhibition and Medicinal Chemistry
17 1 (2002): 45-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036336276&partnerID=MN8TOARS.
10.1080/14756360290019944
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