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Aji Alex Moothedathu Raynold. Completed the Doktor (PhD) in Biomedical Engineering in 2017/09/20 by Indian Institute of Technology Delhi Center for Biomedical Engineering, Doktor (PhD) in Biomedical Engineering in 2017/09/20 by All India Institute of Medical Sciences, Master in M.Pharm (Pharmaceutics) in 2010/12/31 by Mahatma Gandhi University - Cheruvandoor Campus and Bachelor in B.Pharm in 2007/04/07 by Government Medical College Thiruvananthapuram. Published 17 articles in journals. Has 1 patent(s) registered. Participated in 9 event(s). Has received 5 awards and/or honors. Participates and/or participated as PhD Student Fellow in 1 project(s), Post-doc Fellow in 1 project(s) and Researcher in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Biomaterials. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Graft copolymers; Polymer Brushes; Drug Delivery; Formulations; Gene Delivery; biomaterials; .
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Identificação

Identificação pessoal

Nome completo
Aji Alex Moothedathu Raynold

Nomes de citação

  • Moothedathu Raynold, Aji Alex

Identificadores de autor

Ciência ID
9010-0779-7E72
ORCID iD
0000-0001-5453-4444

Endereços de correio eletrónico

  • ajialex89@yahoo.com (Profissional)
  • ajialex@cnc.uc.pt (Profissional)

Telefones

Telemóvel
  • (+351) 911 Ext.: 161016 (Pessoal)
  • (+351) 911161016 (Pessoal)

Moradas

  • Praca Marques de Marialva 1, Edificio Combatentes 1, Sotao Esq, Cantanhede, Portugal 3060-133, 3060-133, Cantanhede, Cantanhede, Portugal (Pessoal)

Websites

  • https://orcid.org/0000-0001-5453-4444 (Profissional)
  • https://scholar.google.co.in/citations?user=XAhQdKUAAAAJ&hl=en (Académico)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Hindi Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Malaiala (Idioma materno)
Formação
Grau Classificação
2011/01/03 - 2017/09/20
Concluído
 Biomedical Engineering (Doktor (PhD))
Especialização em Industrial Biomaterials
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia

All India Institute of Medical Sciences, Índia
"Development of cationic nanosystems based on poly (styrene-alt-maleic anhydride) for combinatorial delivery of drug and nucleic acid in cancer therapy " (TESE/DISSERTAÇÃO)
 Biomaterials
2007/10/22 - 2010/12/31
Concluído
 M.Pharm (Pharmaceutics) (Master)
Especialização em Pharmaceutics
Mahatma Gandhi University - Cheruvandoor Campus, Índia
"Formulation & evaluation of solid lipid nanoparticles for intestinal lymphatic targeting of antiretroviral drug (lopinavir) " (TESE/DISSERTAÇÃO)
 Postgraduate
2002/09/20 - 2007/04/07
Concluído
 B.Pharm (Bachelor)
Especialização em Pharmacy
Government Medical College Thiruvananthapuram, Índia
 Graduate
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/05/01 - Atual Pós-doutorado (Investigação) EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Bélgica
Centre for Neuroscience and Cell Biology (Centro de Neurociências e Biologia Celular), Portugal
2020/02/10 - 2022/02/09 Pós-doutorado (Investigação) Virginia Commonwealth University, Estados Unidos
Virginia Commonwealth University, Estados Unidos
2018/03/20 - 2020/02/07 Pós-doutorado (Investigação) Commonwealth Secretariat, Reino Unido
Queen Mary University of London, Reino Unido
2010/03/15 - 2010/12/31 Assistente de Investigação (carreira) (Investigação) DRDO Institute of Nuclear Medicine and Allied Sciences, Índia
DRDO Institute of Nuclear Medicine and Allied Sciences, Índia

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/09/11 - 2018/03/07 Project Scientist Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
Projetos

Bolsa

Designação Financiadores
2018 - 2020/02/07 Development of cationic polymer brushes for efficient gene delivery applications
INRF-2017-179
Bolseiro de Pós-Doutoramento
Queen Mary University of London - Mile End Campus, Reino Unido
 Commonwealth Secretariat
Concluído
2017 - 2018/03/07 Artificial skin (Bio-inspired bi-layer polymeric hybrid scaffold) for burn injuries and trauma care
F.NO.41-2/2015-T.S.I (PT) (ANN.I SL.24)
Investigador
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
 India Ministry of Human Resource Development
Em curso
2014 - 2017/03/01 Development of Stimuli Responsive Biocompatible Polymeric Nanoparticles for Targeted Drug Delivery in Breast Cancer
BT/PR14132/NNT/28/855/2015
Bolseiro de Doutoramento
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
 Department of Biotechnology Ministry of Science and Technology
Concluído
Produções

Publicações

Artigo em conferência
  1. Raynold, Aji. "Development and in vitro evaluation of an oral floating matrix tablet formulation of calcium di-sodium EDTA using gamma scintigraphy". Trabalho apresentado em SNMICON-2010: 42. annual conference of the Society of Nuclear Medicine (India) on molecular imaging and targeted radionuclide therapy: predicting the future; Chandigarh (India); 11-14 Nov 2010, Chandigarh, 2010.
    Aceite para publicação
  2. Raynold, Aji. "Scintigraphic evaluation of floating, gastroretentive formulation of clarithramycin in healthy human volunteers". Trabalho apresentado em SNMICON-2010: 42. annual conference of the Society of Nuclear Medicine (India) on molecular imaging and targeted radionuclide therapy: predicting the future; Chandigarh (India); 11-14 Nov 2010, Chandigarh, 2010.
    Aceite para publicação
Artigo em revista
  1. "Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-26695-w.
    10.1038/s41467-021-26695-w
  2. "LC-MS/MS method for simultaneous quantification of dexamethasone and tobramycin in rabbit ocular biofluids". Journal of Chromatography B 1170 (2021): 122610-122610. http://dx.doi.org/10.1016/j.jchromb.2021.122610.
    10.1016/j.jchromb.2021.122610
  3. "3D engineering for optic neuropathy treatment". Drug Discovery Today 26 1 (2021): 181-188. http://dx.doi.org/10.1016/j.drudis.2020.09.034.
    10.1016/j.drudis.2020.09.034
  4. Raynold, Aji. "Comparative Assessment of Active Targeted Redox Sensitive Polymersomes Based on pPEGMA-S-S-PLA Diblock Copolymer with Marketed Nanoformulation". Biomacromolecules 19 7 (2018): 2549-2566. https://doi.org/10.1021/acs.biomac.8b00178.
    10.1021/acs.biomac.8b00178
  5. Chetan Nehate; Aji Alex Moothedathu Raynold; Veena Koul. "ATRP fabricated and short chain polyethyleneimine grafted redox sensitive polymeric nanoparticles for co-delivery of anticancer drug and siRNA in cancer therapy". ACS Applied Materials & Interfaces (2017): https://doi.org/10.1021%2Facsami.7b11716.
    10.1021/acsami.7b11716
  6. M.R. Aji Alex; Chetan Nehate; Srivani Veeranarayanan; D. Sakthi Kumar; Ritu Kulshreshtha; Veena Koul. "Self assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapy". Biomaterials 133 (2017): 94-106. https://doi.org/10.1016%2Fj.biomaterials.2017.04.022.
    10.1016/j.biomaterials.2017.04.022
  7. Chetan Nehate; M.R. Aji Alex; Arun Kumar; Veena Koul. "Combinatorial delivery of superparamagnetic iron oxide nanoparticles (¿Fe 2 O 3 ) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cells". Materials Science and Engineering: C 75 (2017): 1128-1143. https://doi.org/10.1016/j.msec.2017.03.024.
    10.1016/j.msec.2017.03.024
  8. Arun Kumar; Shantanu V. Lale; M.R. Aji Alex; Veena Choudhary; Veena Koul. "Folic acid and trastuzumab conjugated redox responsive random multiblock copolymeric nanocarriers for breast cancer therapy: In-vitro and in-vivo studies". Colloids and Surfaces B: Biointerfaces 149 (2017): 369-378. https://doi.org/10.1016%2Fj.colsurfb.2016.10.044.
    10.1016/j.colsurfb.2016.10.044
  9. M. R. Aji Alex; Srivani Veeranarayanan; Aby Cheruvathoor Poulose; Chetan Nehate; D. Sakthi Kumar; Veena Koul. "Click modified amphiphilic graft copolymeric micelles of poly(styrene-alt-maleic anhydride) for combinatorial delivery of doxorubicin and plk-1 siRNA in cancer therapy". J. Mater. Chem. B 4 45 (2016): 7303-7313. https://doi.org/10.1039%2Fc6tb02094a.
    10.1039/c6tb02094a
  10. Pramod, K.; Aji Alex, M.R.; Singh, M.; Dang, S.; Ansari, S.H.; Ali, J.. "Eugenol nanocapsule for enhanced therapeutic activity against periodontal infections". Journal of Drug Targeting 24 1 (2016): 24-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955115014&partnerID=MN8TOARS.
    10.3109/1061186X.2015.1052071
  11. Baby, J.N.; Pramod, K.; John, S.; Aji Alex, M.R.; Suneesh, C.V.; Tahir, M.A.. "Quantification of zinc and lithium in zinc oxide quantum dots by atomic absorption spectroscopy". Research Journal of Pharmaceutical, Biological and Chemical Sciences 6 6 (2015): 973-977. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951729927&partnerID=MN8TOARS.
  12. Baby, J.N.; Pramod, K.; John, S.; Aji Alex, M.R.; Suneesh, C.V.; Kapoor, S.; Tahir, M.A.. "Preparation and evaluation of tunable emission zinc oxide quantum dots for gene delivery". International Journal of Pharmaceutical Sciences Review and Research 35 1 (2015): 191-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949647796&partnerID=MN8TOARS.
  13. Aji Alex, M.R.; Nagpal, N.; Kulshreshtha, R.; Koul, V.. "Synthesis and evaluation of cationically modified poly(styrene-alt-maleic anhydride) nanocarriers for intracellular gene delivery". RSC Advances 5 28 (2015): 21931-21944. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923902351&partnerID=MN8TOARS.
    10.1039/c5ra00409h
  14. Alex, A.; Paul, W.; Chacko, A.J.; Sharma, C.P.. "Enhanced delivery of lopinavir to the CNS using Compritol ®-based solid lipid nanoparticles". Therapeutic Delivery 2 1 (2011): 25-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954567170&partnerID=MN8TOARS.
    10.4155/tde.10.96
  15. Aji Alex, M.R.; Chacko, A.J.; Jose, S.; Souto, E.B.. "Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting". European Journal of Pharmaceutical Sciences 42 1-2 (2011): 11-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650678527&partnerID=MN8TOARS.
    10.1016/j.ejps.2010.10.002
Capítulo de livro
  1. Qu, F.; Raynold, A. M.; Gautrot, J. E.. "Chapter 11. Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications". In Soft Matter for Biomedical Applications, 264-300. Royal Society of Chemistry, 2021.

Propriedade Intelectual

Patente
  1. Raynold, Aji; Veena Koul. 2017. "Stimuli sensitive polymeric nanosystems for co-delivery of drugs and nucleic acids (https://ipindiaservices.gov.in/PatentSearch/PatentSearch/ViewApplicationStatus) Patent number 201711008171". Índia.
    Pendente
Pedido provisório de patente
  1. 2022. "Xu Q, Qin C, Aji Alex M.R., Meng T, Banks M, Townsend E, Novel Nor-LAAM formulations for treating opioid use disorders".
    Protegido
  2. 2021. "Xu Q, O Keffee C, Aji Alex M.R, Sudarjit H, Novel LAAM buccal film compositions and methods of use thereof in treatment of opioid use disorders, VCU, XU-21-034F".
    Protegido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2015/10/01 Oral presentation titled ‘Designing of safe and effective polymeric nanocarriers for delivery of drugs and genes in cancer therapy’ at the ACS on Campus event held at Indian Institute of Technology Delhi, India on 1st October 2015. ACS on Campus event
Indian Institute of Technology Delhi (Delhi, Índia)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2018/03/20 - 2020/02/07 The objective of the project was to synthesize cationic polymer brush grafts over silica nanoparticles and evaluate their gene delivery efficacy. During this time period, I have got hand on experience in polymer brush synthesis, characterization and evaluation of their transfection efficiency in fibroblast cells.
Queen Mary University of London - Mile End Campus, Reino Unido
2019/06/05 - 2019/06/07 Poster presentation titled ‘Polymer brush based vectors for oligonucleotide delivery in 3D hydrogels’ in Advanced Functional Polymers for Medicine (AFPM) 2019 international conference held at Aalto University, Espoo, Finland from 05 th - 07 th June 2019
Simpósio
 Advanced functional polymers for medicine (AFPM) 2019
Aalto-yliopisto, Finlândia
2017/09/11 - 2018/03/07 Research Projects- • Artificial skin (Bio-inspired bi-layer polymeric hybrid scaffold) for burn injuries and trauma care I have formulated and optimized highly porous gelatin-based scaffold and evaluated its physicochemical properties like tensile strength, wettability, porosity etc. and studied it’s in vitro and in vivo biocompatibility. Wound healing efficiency of the scaffold has been evaluated in Wistar rats, by generating second degree burn wounds, as per the CPCSEA guidelines. This project was a part of make in India program (IMPRINT).
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
2017/04/21 - 2017/04/22 Poster presentation titled ‘Development of efficient and stable micelles for co-delivery of drug and siRNA in cancer therapy’ in 13th Annual Open House held at Indian Institute of Technology Delhi, India on 22nd April 2017
Exposição
 13th Annual Open House
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
2016/11/24 - 2016/11/26 Poster presentation titled ‘Click modified amphiphilic graft copolymeric micelles of poly (styrene-alt-maleic anhydride) for combinatorial delivery of doxorubicin and plk 1 siRNA in cancer therapy’ in 1st Annual Conference of Indian Society of Nanomedicine held at All India Institute of Medical Science, New Delhi, India from 24th-26th November 2016 (Received best poster award)
Conferência
 1st Annual Conference of Indian Society of Nanomedicine
All India Institute of Medical Sciences, Índia
2015/11/26 - 2015/11/28 Poster presentation titled ‘Development of poly (styrene-alt-maleic anhydride) based nanocarriers for intracellular gene delivery’ in the 13 th International symposium on bioscience and nanotechnology held at Bio-Nano Electronics Research Center, Toyo University, Japan from 26th- 28 th November 2015.
Simpósio
 13 th International symposium on bioscience and nanotechnology
Toyo Daigaku Shakai Gakubu Daigakuin Shakaigaku Kenkyuka Shakai Shinrigaku, Japão
2014/10/27 - 2014/10/30 Poster presentation titled ‘Synthesis and evaluation of poly (styrene-alt-maleic anhydride) based nanocarriers for gene delivery application’ in International Conference on Polymeric Biomaterials, Bioengineering & Biodiagnostics held at New Delhi, India from 27th- 30 th October 2014.
Conferência
 International Conference on Polymeric Biomaterials, Bioengineering & Biodiagnostics
2010/03/15 - 2010/12/31 Research Projects- • Development of chitosan based wound dressing gels and antifreeze intravenous fluid for soldiers in the highaltitude war zone. My responsibilities in this project were to formulate chitosan-based gel for wound healing, evaluation of the wound healing efficiency in vivo, formulation of anti-freeze intravenous fluid, radiolabeling of drugs and their pharmacoscintigraphic evaluations, in vivo, using gamma scintigraphy.
Outro
DRDO Institute of Nuclear Medicine and Allied Sciences, Índia
2010/04/14 - 2010/04/15 Poster presentation titled ‘Design and development of smart polymeric nanoparticles for overcoming chemotherapy in cancer’. 10th Annual Open House, Indian Institute of Technology Delhi, 14th April, 2010. •
Exposição
 10th Annual Open House
Indian Institute of Technology Delhi, Índia

Expedição científica

Descrição da atividade Instituição / Organização
2020/02/10 - 2022/01/28 Participated as a co-inventor in an invention (filed) entitled Xu Q, Qin C, Aji Alex M.R., Meng T, Banks M, Townsend E, Novel Nor-LAAM formulations for treating opioid use disorders, VCU invention disclosure, XU-22-001F, Jan 28, 2022
2020/02/10 - 2021/10/21 Participated as a co-inventor in an invention (filed) entitled “Novel LAAM buccal film compositions and methods of use thereof in treatment of opioid use disorders”, VCU, XU-21-034F

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2020/06/02 - Atual Journal of Drug Delivery Science and Technology Elsevier
Distinções

Prémio

2021 Marie Sklodowska-Curie Individual fellowship
European Union, Bélgica
2018 Commonwealth Rutherford Fellowship in the year 2018
Commonwealth Secretariat, Reino Unido
2011 Indian Institute of Technology Delhi Research Scholar Fellowship (INR 4,32,000 annually) from January 2011 - December 2015
Indian Institute of Technology Delhi, Índia
2007 GATE Research Scholarship (INR 96,000 annually) from All India Council for Technical Education (AICTE), Government of India from October 2007 - December 2009
All India Council for Technical Education, Índia

Outra distinção

2017 Dogra Educational Endowment Gold Medal for the best scientific publication from Centre for Biomedical Engineering, IIT Delhi in the year 2016-2017. •
Indian Institute of Technology Delhi, Índia
2016 Best poster presentation award at Nanobioteck conference conducted at All India Institute of Medical Sciences (AIIMS), New Delhi, India, November 2016. •
All India Institute of Medical Sciences, Índia