???global.info.a_carregar???
Aji Alex Moothedathu Raynold. Completed the Doktor (PhD) in Biomedical Engineering in 2017/09/20 at Indian Institute of Technology Delhi (India), Master in M.Pharm (Pharmaceutics) at Mahatma Gandhi University - Cheruvandoor Campus and Bachelor in B.Pharm at Government Medical College Thiruvananthapuram. Published 17 articles in journals. Has 1 Indian patent(s) registered and 2 US patents provisionally applied. Participated in 14 event(s). Has received 10 awards and/or honors. Participates and/or participated as PhD Student Fellow in 1 grant(s), Project Scientist in 1 grant, Primary Investigator in 3 grant(s) and Researcher in 4 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Biomaterials. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Graft copolymers; Polymer Brushes; Drug Delivery; Formulations; Gene Delivery; Biomaterials; .
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Aji Alex Moothedathu Raynold

Nomes de citação

  • Moothedathu Raynold, Aji Alex

Identificadores de autor

Ciência ID
9010-0779-7E72
ORCID iD
0000-0001-5453-4444

Endereços de correio eletrónico

  • ajialex89@yahoo.com (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Hindi Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Malaiala (Idioma materno)
Formação
Grau Classificação
2011/01/03 - 2017/09/20
Concluído
 Biomedical Engineering (Doktor (PhD))
Especialização em Industrial Biomaterials
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia

All India Institute of Medical Sciences, Índia
"Development of cationic nanosystems based on poly (styrene-alt-maleic anhydride) for combinatorial delivery of drug and nucleic acid in cancer therapy " (TESE/DISSERTAÇÃO)
 Biomaterials
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/11/18 - 2016/02/15 Investigador visitante (Investigação) Bio-Nano Electronics Research Centre (BNERC) Toyo University Japan, Japão
Bio-Nano Electronics Research Centre (BNERC) Toyo University Japan, Japão
2010/03/15 - 2010/12/31 Assistente de Investigação (carreira) (Investigação) DRDO Institute of Nuclear Medicine and Allied Sciences, Índia
DRDO Institute of Nuclear Medicine and Allied Sciences, Índia
2009/03/31 - 2009/12/31 Investigador visitante (Investigação) Sree Chitra Tirunal Institute for Medical Sciences and Technology, Índia
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Índia

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/09/20 - 2018/03/07 Project Scientist (IMPRINT) Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
Projetos

Bolsa

Designação Financiadores
2023/03/01 - 2024/06/30 Polymer brush grafted exosomes for microRNA delivery through blood brain barrier (BBB)
2022.02803.PTDC
Investigador responsável
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/05/01 - 2024/04/30 Design and development of exosomes with brush type architecture as RNA delivery vectors for active targeting of blood brain barrier (BBB)
101019325
Investigador responsável
Universidade de Coimbra, Portugal
 European Commission
Em curso
2018/03/20 - 2020/02/07 Development of cationic polymer brushes for efficient gene delivery applications
INRF-2017-179
Investigador responsável
Queen Mary University of London - Mile End Campus, Reino Unido
 Commonwealth Secretariat
Concluído
2015/05/08 - 2018/05/07 Development of hybrid polymeric nanosystems for combinatorial targeted delivery of siRNA and drug in breast cancer therapy
BT/PR10191/NNT//28/717/2013
Bolseiro de Doutoramento
Indian Institute of Technology Delhi, Índia
 Department of Biotechnology Ministry of Science and Technology
Concluído
2017/09/20 - 2018/03/07 Artificial skin (Bio-inspired bi-layer polymeric hybrid scaffold) for burn injuries and trauma care
F.NO.41-2/2015-T.S.I (PT) (ANN.I SL.24)
Bolseiro de Iniciação Científica
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
 India Ministry of Human Resource Development
Concluído
Produções

Publicações

Artigo em conferência
  1. Moothedathu Raynold, Aji Alex. "Development and in vitro evaluation of an oral floating matrix tablet formulation of calcium di-sodium EDTA using gamma scintigraphy". Trabalho apresentado em SNMICON-2010: 42. annual conference of the Society of Nuclear Medicine (India) on molecular imaging and targeted radionuclide therapy: predicting the future; Chandigarh (India); 11-14 Nov 2010, Chandigarh, 2010.
    Publicado
  2. Raynold, Aji. "Scintigraphic evaluation of floating, gastroretentive formulation of clarithramycin in healthy human volunteers". Trabalho apresentado em SNMICON-2010: 42. annual conference of the Society of Nuclear Medicine (India) on molecular imaging and targeted radionuclide therapy: predicting the future; Chandigarh (India); 11-14 Nov 2010, Chandigarh, 2010.
    Publicado
Artigo em revista
  1. Tuo Meng; Jinhua Zheng; Min Chen; Yang Zhao; Hadi Sudarjat; Aji Alex M.R.; Vineet Kulkarni; et al. "Six-month effective treatment of corneal graft rejection". Science Advances 9 12 (2023): http://dx.doi.org/10.1126/sciadv.adf4608.
    10.1126/sciadv.adf4608
  2. Ciofani, Gianni; Campisi, Marco; Mattu, Clara; Kamm, Roger D; Chiono, Valeria; Raynold, Aji Alex Moothedathu; Freitas, João S; et al. "Roadmap on nanomedicine for the central nervous system". Journal of Physics: Materials 6 2 (2023): 022501. http://dx.doi.org/10.1088/2515-7639/acab88.
    10.1088/2515-7639/acab88
  3. Moothedathu Raynold, Aji Alex; Li, Danyang; Chang, Lan; Gautrot, Julien E.. Autor correspondente: Gautrot, Julien E.. "Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-26695-w.
    10.1038/s41467-021-26695-w
  4. "LC-MS/MS method for simultaneous quantification of dexamethasone and tobramycin in rabbit ocular biofluids". Journal of Chromatography B 1170 (2021): 122610-122610. http://dx.doi.org/10.1016/j.jchromb.2021.122610.
    10.1016/j.jchromb.2021.122610
  5. "3D engineering for optic neuropathy treatment". Drug Discovery Today 26 1 (2021): 181-188. http://dx.doi.org/10.1016/j.drudis.2020.09.034.
    10.1016/j.drudis.2020.09.034
  6. Raynold, Aji. "Comparative Assessment of Active Targeted Redox Sensitive Polymersomes Based on pPEGMA-S-S-PLA Diblock Copolymer with Marketed Nanoformulation". Biomacromolecules 19 7 (2018): 2549-2566. https://doi.org/10.1021/acs.biomac.8b00178.
    10.1021/acs.biomac.8b00178
  7. Chetan Nehate; Aji Alex Moothedathu Raynold; Veena Koul. "ATRP fabricated and short chain polyethyleneimine grafted redox sensitive polymeric nanoparticles for co-delivery of anticancer drug and siRNA in cancer therapy". ACS Applied Materials & Interfaces (2017): https://doi.org/10.1021%2Facsami.7b11716.
    10.1021/acsami.7b11716
  8. M.R. Aji Alex; Chetan Nehate; Srivani Veeranarayanan; D. Sakthi Kumar; Ritu Kulshreshtha; Veena Koul. "Self assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapy". Biomaterials 133 (2017): 94-106. https://doi.org/10.1016%2Fj.biomaterials.2017.04.022.
    10.1016/j.biomaterials.2017.04.022
  9. Chetan Nehate; M.R. Aji Alex; Arun Kumar; Veena Koul. "Combinatorial delivery of superparamagnetic iron oxide nanoparticles (¿Fe 2 O 3 ) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cells". Materials Science and Engineering: C 75 (2017): 1128-1143. https://doi.org/10.1016/j.msec.2017.03.024.
    10.1016/j.msec.2017.03.024
  10. Arun Kumar; Shantanu V. Lale; M.R. Aji Alex; Veena Choudhary; Veena Koul. "Folic acid and trastuzumab conjugated redox responsive random multiblock copolymeric nanocarriers for breast cancer therapy: In-vitro and in-vivo studies". Colloids and Surfaces B: Biointerfaces 149 (2017): 369-378. https://doi.org/10.1016%2Fj.colsurfb.2016.10.044.
    10.1016/j.colsurfb.2016.10.044
  11. M. R. Aji Alex; Srivani Veeranarayanan; Aby Cheruvathoor Poulose; Chetan Nehate; D. Sakthi Kumar; Veena Koul. "Click modified amphiphilic graft copolymeric micelles of poly(styrene-alt-maleic anhydride) for combinatorial delivery of doxorubicin and plk-1 siRNA in cancer therapy". J. Mater. Chem. B 4 45 (2016): 7303-7313. https://doi.org/10.1039%2Fc6tb02094a.
    10.1039/c6tb02094a
  12. Pramod, K.; Aji Alex, M.R.; Singh, M.; Dang, S.; Ansari, S.H.; Ali, J.. "Eugenol nanocapsule for enhanced therapeutic activity against periodontal infections". Journal of Drug Targeting 24 1 (2016): 24-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955115014&partnerID=MN8TOARS.
    10.3109/1061186X.2015.1052071
  13. Baby, J.N.; Pramod, K.; John, S.; Aji Alex, M.R.; Suneesh, C.V.; Tahir, M.A.. "Quantification of zinc and lithium in zinc oxide quantum dots by atomic absorption spectroscopy". Research Journal of Pharmaceutical, Biological and Chemical Sciences 6 6 (2015): 973-977. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951729927&partnerID=MN8TOARS.
  14. Baby, J.N.; Pramod, K.; John, S.; Aji Alex, M.R.; Suneesh, C.V.; Kapoor, S.; Tahir, M.A.. "Preparation and evaluation of tunable emission zinc oxide quantum dots for gene delivery". International Journal of Pharmaceutical Sciences Review and Research 35 1 (2015): 191-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949647796&partnerID=MN8TOARS.
  15. Aji Alex, M.R.; Nagpal, N.; Kulshreshtha, R.; Koul, V.. "Synthesis and evaluation of cationically modified poly(styrene-alt-maleic anhydride) nanocarriers for intracellular gene delivery". RSC Advances 5 28 (2015): 21931-21944. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923902351&partnerID=MN8TOARS.
    10.1039/c5ra00409h
  16. Alex, A.; Paul, W.; Chacko, A.J.; Sharma, C.P.. "Enhanced delivery of lopinavir to the CNS using Compritol ®-based solid lipid nanoparticles". Therapeutic Delivery 2 1 (2011): 25-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954567170&partnerID=MN8TOARS.
    10.4155/tde.10.96
  17. Aji Alex, M.R.; Chacko, A.J.; Jose, S.; Souto, E.B.. "Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting". European Journal of Pharmaceutical Sciences 42 1-2 (2011): 11-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650678527&partnerID=MN8TOARS.
    10.1016/j.ejps.2010.10.002
Capítulo de livro
  1. Qu, F.; Raynold, A. M.; Gautrot, J. E.. "Chapter 11. Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications". In Soft Matter for Biomedical Applications, 264-300. Royal Society of Chemistry, 2021.

Propriedade Intelectual

Patente
  1. Raynold, Aji; Veena Koul. 2018. "Stimuli sensitive polymeric nanosystems for co-delivery of drugs and nucleic acids (https://ipindiaservices.gov.in/PatentSearch/PatentSearch/ViewApplicationStatus) Patent number 201711008171". Índia.
    Permitida
Pedido provisório de patente
  1. 2022. "Xu Q, Qin C, Aji Alex M.R., Meng T, Banks M, Townsend E, Novel Nor-LAAM formulations for treating opioid use disorders".
    Protegido
  2. 2021. "Xu Q, O Keffee C, Aji Alex M.R, Sudarjit H, Novel LAAM buccal film compositions and methods of use thereof in treatment of opioid use disorders, VCU, XU-21-034F".
    Protegido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2015/10/01 Oral presentation titled ‘Designing of safe and effective polymeric nanocarriers for delivery of drugs and genes in cancer therapy’ at the ACS on Campus event held at Indian Institute of Technology Delhi, India on 1st October 2015. ACS on Campus event
Indian Institute of Technology Delhi (Delhi, Índia)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2017/09/23 - 2017/09/23 Participated and presented poster titled ' Polymeric nanoparticles for co-delivery of siRNA and anticancer drugs' during Industry day conducted at IIT Delhi (India)
Oficina (workshop)
 Industry Day
Indian Institute of Technology Delhi, Índia
2017/04/21 - 2017/04/22 Poster presentation titled ‘Development of efficient and stable micelles for co-delivery of drug and siRNA in cancer therapy’ in 13th Annual Open House held at Indian Institute of Technology Delhi, India on 22nd April 2017
Exposição
 13th Annual Open House
Indian Institute of Technology Delhi Center for Biomedical Engineering, Índia
2016/11/24 - 2016/11/26 Poster presentation titled ‘Click modified amphiphilic graft copolymeric micelles of poly (styrene-alt-maleic anhydride) for combinatorial delivery of doxorubicin and plk 1 siRNA in cancer therapy’ in 1st Annual Conference of Indian Society of Nanomedicine held at All India Institute of Medical Science, New Delhi, India from 24th-26th November 2016 (Received best poster award)
Conferência
 1st Annual Conference of Indian Society of Nanomedicine
All India Institute of Medical Sciences, Índia
2015/11/26 - 2015/11/28 Poster presentation titled ‘Development of poly (styrene-alt-maleic anhydride) based nanocarriers for intracellular gene delivery’ in the 13 th International symposium on bioscience and nanotechnology held at Bio-Nano Electronics Research Center, Toyo University, Japan from 26th- 28 th November 2015.
Simpósio
 13 th International symposium on bioscience and nanotechnology
Toyo Daigaku Shakai Gakubu Daigakuin Shakaigaku Kenkyuka Shakai Shinrigaku, Japão
2015/11/04 - 2015/11/04 Participated in Indo-Japan Symposium - PIKNIKH Series VII (https://web.iitd.ac.in/~sundar/meeting/piknikh2015-2/participants.html) INDIAN INSTITUTE OF TECHNOLOGY DELHI NOVEMBER 04, 2015
Conferência
 Indo-Japan Symposium - PIKNIKH Series VII INDIAN INSTITUTE OF TECHNOLOGY DELHI NOVEMBER 04, 2015
Indian Institute of Technology Delhi, Índia
2014/10/27 - 2014/10/30 Poster presentation titled ‘Synthesis and evaluation of poly (styrene-alt-maleic anhydride) based nanocarriers for gene delivery application’ in International Conference on Polymeric Biomaterials, Bioengineering & Biodiagnostics held at New Delhi, India from 27th- 30 th October 2014.
Conferência
 International Conference on Polymeric Biomaterials, Bioengineering & Biodiagnostics
2014/04/14 - 2014/04/15 Poster presentation titled ‘Design and development of smart polymeric nanoparticles for overcoming chemotherapy in cancer’. 10th Annual Open House, Indian Institute of Technology Delhi, 14th April, 2010. •
Exposição
 10th Annual Open House
Indian Institute of Technology Delhi, Índia
2010/11/11 - 2010/11/14 Participated in the nuclear medicine conference conducted by The Society of Nuclear Medicine-India (SNMI) at the at the Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India and presented posters detailing pharmacoscintigraphic studies of pharmaceutical formulations (https://humanhealth.iaea.org/HHW/NuclearMedicine/Nuclear_Medicine_Events/Archive2010/SNMICON2010/index.htm)(https://www.osti.gov/etdeweb/biblio/21414523 ; https://www.osti.gov/etdeweb/biblio/21414518)
Conferência
 SNMICON2010 (https://humanhealth.iaea.org/HHW/NuclearMedicine/Nuclear_Medicine_Events/Archive2010/SNMICON2010/index.html)
Post Graduate Institute of Medical Education and Research, Índia

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2013/01/01 - 2014/06/30 2013-2014 Industrial Biomedical Technology (Master) Indian Institute of Technology Delhi, Índia

Expedição científica

Descrição da atividade Instituição / Organização
2015/11/18 - 2016/02/15 I have done research on co-delivery of PLK-1 siRNA and Doxorubicin using core shell polymeric nanoparticles. Bio-Nano Electronics Research Centre (BNERC) Toyo University Japan, Japão
2009/03/31 - 2009/12/31 I have done research on the targeting of solid lipid nanoparticles loaded with anti retroviral drug to central nervous system (CNS). Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Índia

Membro de associação

Nome da associação Tipo de participação
2017/11/04 - Atual Member of IIT Delhi Alumini association Member of alumini association of Indian Institute of Technology, Delhi (India)
2009/07/12 - Atual Member and licensed pharmacist of Kerala state pharmacy council (Kerala, India) Member of state pharmacy council which is an association of licensed pharmacists from the state of Kerala, India

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2015/06/01 - 2015/12/31 Elected representative of Nalanda hostel Indian Institute of Delhi (India) Campus during the year 2015
Coordenador
 Indian Institute of Technology Delhi, Índia
2014/04/19 - 2014/04/19 Student Coordinator from Centre for Biomedical Engineering, IIT, Delhi during the Annual Open House Workshop 2014-2015 conducted at IIT Delhi.
Coordenador
 Indian Institute of Technology Delhi, Índia
Distinções

Prémio

2021 Marie Sklodowska-Curie Individual fellowship
European Union, Bélgica
2019 Seal of excellence award
European Union, Bélgica
2018 Commonwealth Rutherford Fellowship in the year 2018
Commonwealth Secretariat, Reino Unido
2017 Dogra Educational Endowment Gold Medal for the best scientific publication from Centre for Biomedical Engineering, IIT Delhi in the year 2016-2017. •
Indian Institute of Technology Delhi, Índia
2016 Best poster presentation award at Nanobioteck conference conducted at All India Institute of Medical Sciences (AIIMS), New Delhi, India, November 2016. •
All India Institute of Medical Sciences, Índia
2011 Indian Institute of Technology Delhi Research Scholar Fellowship (INR 4,32,000 annually) from January 2011 - December 2015
Indian Institute of Technology Delhi, Índia
2007 GATE Research Scholarship (INR 96,000 annually) from All India Council for Technical Education (AICTE), Government of India from October 2007 - December 2009
All India Council for Technical Education, Índia

Outra distinção

2022 Highly commended research article (https://cscuk.fcdo.gov.uk/meet-the-2022-csc-research-impact-award-winners/
Commonwealth Scholarship Commission, Reino Unido