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Identificação

Identificação pessoal

Nome completo
Shiva K Tyagarajan

Identificadores de autor

Ciência ID
8F1E-A709-1D51
ORCID iD
0000-0003-0074-1805
Formação
Grau Classificação
2000/04/01 - 2006/05/01
Concluído
 Biochemistry, Microbiology and Molecular Biology (Doctor of Philosophy)
The Pennsylvania State University - University Park Campus, Estados Unidos
1997/04/15 - 1999/05/01
Concluído
 Industrial Microbiology (Postgraduate Certificate)
Loyola College, Índia
1994/04/15 - 1997/05/01
Concluído
 Botany and Biotechnology (Bachelor)
University of Madras, Índia
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/02/01 - 2017/01/31 Investigador principal (carreira) (Investigação) Universität Zürich Institut für Pharmakologie und Toxikologie, Suiça
2006/02/01 - 2012/01/31 Pós-doutorado (Investigação) Universität Zürich Institut für Pharmakologie und Toxikologie, Suiça

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2026/01/01 - Atual Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
(...)
2024/12/01 - 2031/12/01 Professor Associado Convidado (Docente Universitário) Universität Zürich Institut für Pharmakologie und Toxikologie, Suiça
2017/02/01 - 2024/12/31 Professor Auxiliar (Docente Universitário) Universität Zürich Institut für Pharmakologie und Toxikologie, Suiça

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/01/01 - 2023/12/31 Director Interdisciplinary Brain Sciences (IDB) Universität Zürich Institut für Pharmakologie und Toxikologie, Suiça
Eidgenossische Technische Hochschule Zürich Campus Hönggerberg, Suiça
Produções

Publicações

Artigo em revista
  1. Yuan-Chen Tsai; Waleed ElGrawani; Christine Muheim; Andrea Spinnler; Benjamin F. N. Campbell; Denis Lasic; Mohammad Hleihil; Steven A. Brown; Shiva K. Tyagarajan. "Modulation of sleep/wake patterns by gephyrin phosphorylation status". European Journal of Neuroscience (2024): https://doi.org/10.1111/ejn.16464.
    10.1111/ejn.16464
  2. Cramer, T.M.L.; Tyagarajan, S.K.. "Protocol for the culturing of primary hippocampal mouse neurons for functional in vitro studies". STAR Protocols 5 2 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85189920436&partnerID=MN8TOARS.
    10.1016/j.xpro.2024.102991
  3. Campbell, B.F.N.; Cruz-Ochoa, N.; Otomo, K.; Lukacsovich, D.; Espinosa, P.; Abegg, A.; Luo, W.; et al. "Gephyrin phosphorylation facilitates sexually dimorphic development and function of parvalbumin interneurons in the mouse hippocampus". Molecular Psychiatry 29 8 (2024): 2510-2526. http://www.scopus.com/inward/record.url?eid=2-s2.0-85188127447&partnerID=MN8TOARS.
    10.1038/s41380-024-02517-5
  4. Tsai, Y.-C.; Hleihil, M.; Otomo, K.; Abegg, A.; Cavaccini, A.; Panzanelli, P.; Cramer, T.; et al. "The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation". Scientific Reports 14 1 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85185460003&partnerID=MN8TOARS.
    10.1038/s41598-024-54720-7
  5. Cramer, T.M.L.; Abegg, A.; Tyagarajan, S.K.. "Protocol for in vivo analysis of pre- and post-synaptic protein function in mice". STAR Protocols 5 2 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85195275236&partnerID=MN8TOARS.
    10.1016/j.xpro.2024.103117
  6. Cramer, T.M.L.; Pinan-Lucarre, B.; Cavaccini, A.; Damilou, A.; Tsai, Y.-C.; Bhat, M.A.; Panzanelli, P.; et al. "Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function". Cell Reports 42 8 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85167441406&partnerID=MN8TOARS.
    10.1016/j.celrep.2023.112947
  7. Andreadou, M.; Ingelfinger, F.; De Feo, D.; Cramer, T.L.M.; Tuzlak, S.; Friebel, E.; Schreiner, B.; et al. "IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice". Nature Neuroscience 26 10 (2023): 1701-1712. http://www.scopus.com/inward/record.url?eid=2-s2.0-85172702206&partnerID=MN8TOARS.
    10.1038/s41593-023-01435-z
  8. Duffet, L.; Kosar, S.; Panniello, M.; Viberti, B.; Bracey, E.; Zych, A.D.; Radoux-Mergault, A.; et al. "A genetically encoded sensor for in vivo imaging of orexin neuropeptides". Nature Methods 19 2 (2022): 231-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124446137&partnerID=MN8TOARS.
    10.1038/s41592-021-01390-2
  9. Cramer, T.; Gill, R.; Thirouin, Z.S.; Vaas, M.; Sampath, S.; Martineau, F.; Noya, S.B.; et al. "Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia". Science Advances 8 9 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85125797047&partnerID=MN8TOARS.
    10.1126/sciadv.abj0112
  10. Campbell, B.F.N.; Dittmann, A.; Dreier, B.; Plückthun, A.; Tyagarajan, S.K.. "A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology". eLife 11 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141511865&partnerID=MN8TOARS.
    10.1101/2022.06.30.498253
  11. Olejniczak, I.; Campbell, B.; Tsai, Y.-C.; Tyagarajan, S.K.; Albrecht, U.; Ripperger, J.A.. "Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice". Frontiers in Physiology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140908566&partnerID=MN8TOARS.
    10.3389/fphys.2022.909795
  12. Thirouin, Z.S.; Figueiredo, M.; Hleihil, M.; Gill, R.; Bosshard, G.; McKinney, R.A.; Tyagarajan, S.K.. "Trophic factor BDNF inhibits GABAergic signaling by facilitating dendritic enrichment of SUMO E3 ligase PIAS3 and altering gephyrin scaffold". Journal of Biological Chemistry 298 5 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85129194970&partnerID=MN8TOARS.
    10.1016/j.jbc.2022.101840
  13. Duffet, L.; Kosar, S.; Panniello, M.; Viberti, B.; Bracey, E.; Zych, A.D.; Radoux-Mergault, A.; et al. "Author Correction: A genetically encoded sensor for in vivo imaging of orexin neuropeptides (Nature Methods, (2022), 19, 2, (231-241), 10.1038/s41592-021-01390-2)". Nature Methods 19 4 (2022): 505-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127421246&partnerID=MN8TOARS.
    10.1038/s41592-022-01449-8
  14. Gomez-Castro, F.; Zappettini, S.; Pressey, J.C.; Silva, C.G.; Russeau, M.; Gervasi, N.; Figueiredo, M.; et al. "Convergence of adenosine and GABA signaling for synapse stabilization during development". Science 374 6568 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118868990&partnerID=MN8TOARS.
    10.1126/science.abk2055
  15. van Oostrum, M.; Campbell, B.; Seng, C.; Müller, M.; Dieck, S.; Hammer, J.; Pedrioli, P.G.A.; et al. "Author Correction: Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity (Nature Communications, (2020), 11, 1, (4990), 10.1038/s41467-020-18494-6)". Nature Communications 11 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85095258614&partnerID=MN8TOARS.
    10.1038/s41467-020-19654-4
  16. van Oostrum, M.; Campbell, B.; Seng, C.; Müller, M.; tom Dieck, S.; Hammer, J.; Pedrioli, P.G.A.; et al. "Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity". Nature Communications 11 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85091988569&partnerID=MN8TOARS.
    10.1038/s41467-020-18494-6
  17. Bach, D.R.; Brown, S.A.; Kleim, B.; Tyagarajan, S.K.. "Extracellular matrix: A new player in memory maintenance and psychiatric disorders". Swiss Medical Weekly 149 21-22 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067100398&partnerID=MN8TOARS.
    10.4414/smw.2019.20060
  18. Bach, D.R.; Näf, M.; Deutschmann, M.; Tyagarajan, S.K.; Quednow, B.B.. "Threat memory reminder under matrix metalloproteinase 9 inhibitor doxycycline globally reduces subsequent memory plasticity". Journal of Neuroscience 39 47 (2019): 9424-9434. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075813847&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.1285-19.2019
  19. Brüning, F.; Noya, S.B.; Bange, T.; Koutsouli, S.; Rudolph, J.D.; Tyagarajan, S.K.; Cox, J.; et al. "Sleep-wake cycles drive daily dynamics of synaptic phosphorylation". Science 366 6462 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073116489&partnerID=MN8TOARS.
    10.1126/science.aav3617
  20. Noya, S.B.; Colameo, D.; Brüning, F.; Spinnler, A.; Mircsof, D.; Opitz, L.; Mann, M.; et al. "The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep". Science 366 6462 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073111002&partnerID=MN8TOARS.
    10.1126/science.aav2642
  21. Campbell, B.F.N.; Tyagarajan, S.K.. "Cellular Mechanisms Contributing to the Functional Heterogeneity of GABAergic Synapses". Frontiers in Molecular Neuroscience 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072724437&partnerID=MN8TOARS.
    10.3389/fnmol.2019.00187
  22. Früh, S.; Tyagarajan, S.K.; Campbell, B.; Bosshard, G.; Fritschy, J.-M.. "The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and post-synaptic structures in primary hippocampal cultures". Journal of Neurochemistry 147 4 (2018): 477-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056107767&partnerID=MN8TOARS.
    10.1111/jnc.14572
  23. Virtanen, M.A.; Lacoh, C.M.; Fiumelli, H.; Kosel, M.; Tyagarajan, S.; de Roo, M.; Vutskits, L.. "Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex". Brain Structure and Function 223 4 (2018): 1999-2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040374303&partnerID=MN8TOARS.
    10.1007/s00429-017-1602-0
  24. Battaglia, S.; Renner, M.; Russeau, M.; Côme, E.; Tyagarajan, S.K.; Lévi, S.. "Activity-dependent inhibitory synapse scaling is determined by gephyrin phosphorylation and subsequent regulation of GABAA receptor diffusion". eNeuro 5 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041006623&partnerID=MN8TOARS.
    10.1523/ENEURO.0203-17.2017
  25. Pennacchietti, F.; Vascon, S.; Nieus, T.; Rosillo, C.; Das, S.; Tyagarajan, S.K.; Diaspro, A.; et al. "Nanoscale molecular reorganization of the inhibitory postsynaptic density is a determinant of gabaergic synaptic potentiation". Journal of Neuroscience 37 7 (2017): 1747-1756. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013074751&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.0514-16.2016
  26. Wilkinson, K.A.; Martin, S.; Tyagarajan, S.K.; Arancio, O.; Craig, T.J.; Guo, C.; Fraser, P.E.; Goldstein, S.A.N.; Henley, J.M.. "Commentary: Analysis of SUMO1-conjugation at synapses". Frontiers in Cellular Neuroscience 11 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044562300&partnerID=MN8TOARS.
    10.3389/fncel.2017.00345
  27. Fritschy, J.-M.; Tyagarajan, S.K.. "GABAergic Synaptogenesis: A Case for Cooperation". Neuron 96 4 (2017): 709-711. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033699435&partnerID=MN8TOARS.
    10.1016/j.neuron.2017.11.003
  28. Maffei, A.; Charrier, C.; Caiati, M.D.; Barberis, A.; Mahadevan, V.; Woodin, M.A.; Tyagarajan, S.K.. "Emerging mechanisms underlying dynamics of GABAergic synapses". Journal of Neuroscience 37 45 (2017): 10792-10799. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033576909&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.1824-17.2017
  29. Mukherjee, J.; Cardarelli, R.A.; Cantaut-Belarif, Y.; Deeb, T.Z.; Srivastava, D.P.; Tyagarajan, S.K.; Pangalos, M.N.; et al. "Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses". Proceedings of the National Academy of Sciences of the United States of America 114 44 (2017): 11763-11768. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032741283&partnerID=MN8TOARS.
    10.1073/pnas.1705075114
  30. Ghosh, Himanish; Auguadri, Luca; Battaglia, Sereina; Simone Thirouin, Zahra; Zemoura, Khaled; Messner, Simon; Acuña, Mario A.; et al. "Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission". Nature Communications 7 1 (2016): https://doi.org/10.1038/ncomms13365.
    10.1038/ncomms13365
  31. Früh, Simon; Romanos, Jennifer; Panzanelli, Patrizia; Bürgisser, Daniela; Tyagarajan, Shiva K.; Campbell, Kevin P.; Santello, Mirko; Fritschy, Jean-Marc. "Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells". The Journal of Neuroscience 36 40 (2016): 10296-10313. https://doi.org/10.1523/jneurosci.1823-16.2016.
    10.1523/jneurosci.1823-16.2016
  32. Deprez, F.; Vogt, F.; Floriou-Servou, A.; Lafourcade, C.; Rudolph, U.; Tyagarajan, S.K.; Fritschy, J.-M.. "Partial inactivation of GABAA receptors containing the a5 subunit affects the development of adult-born dentate gyrus granule cells". European Journal of Neuroscience 44 5 (2016): 2258-2271. http://www.scopus.com/inward/record.url?eid=2-s2.0-84985963127&partnerID=MN8TOARS.
    10.1111/ejn.13329
  33. "Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.". PNAS (2015): http://www.ncbi.nlm.nih.gov/pubmed/25535349.
  34. Flores, C.E.; Nikonenko, I.; Mendez, P.; Fritschy, J.-M.; Tyagarajan, S.K.; Muller, D.. "Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation". Proceedings of the National Academy of Sciences of the United States of America 112 1 (2015): E65-E72. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920426339&partnerID=MN8TOARS.
    10.1073/pnas.1411170112
  35. Mircsof, D.; Langouët, M.; Rio, M.; Moutton, S.; Siquier-Pernet, K.; Bole-Feysot, C.; Cagnard, N.; et al. "Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects". Nature Neuroscience 18 12 (2015): 1731-1736. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949132230&partnerID=MN8TOARS.
    10.1038/nn.4169
  36. Deprez, F.; Pallotto, M.; Vogt, F.; Grabiec, M.; Virtanen, M.A.; Tyagarajan, S.K.; Panzanelli, P.; Fritschy, J.-M.. "Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb". Journal of Comparative Neurology 523 13 (2015): 1998-2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937231976&partnerID=MN8TOARS.
    10.1002/cne.23776
  37. Tyagarajan, S.K.; Fritschy, J.-M.. "Gephyrin: A master regulator of neuronal function?". Nature Reviews Neuroscience 15 3 (2014): 141-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897874869&partnerID=MN8TOARS.
    10.1038/nrn3670
  38. Accardi, M.V.; Daniels, B.A.; Brown, P.M.G.E.; Fritschy, J.-M.; Tyagarajan, S.K.; Bowie, D.. "Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84892690009&partnerID=MN8TOARS.
    10.1038/ncomms4168
  39. Lueke, K.; Kaiser, T.; Svetlitchny, A.; Welzel, O.; Wenzel, E.M.; Tyagarajan, S.; Kornhuber, J.; Groemer, T.W.. "Basic presynaptic functions in hippocampal neurons are not affected by acute or chronic lithium treatment". Journal of Neural Transmission 121 2 (2014): 211-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893798095&partnerID=MN8TOARS.
    10.1007/s00702-013-1087-9
  40. Tyagarajan, S.K.; Ghosh, H.; Yévenes, G.E.; Imanishi, S.Y.; Zeilhofer, H.U.; Gerrits, B.; Fritschy, J.-M.. "Extracellular signal-regulated kinase and glycogen synthase kinase 3ß regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism". Journal of Biological Chemistry 288 14 (2013): 9634-9647. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876006492&partnerID=MN8TOARS.
    10.1074/jbc.M112.442616
  41. Fritschy, J.-M.; Panzanelli, P.; Tyagarajan, S.K.. "Molecular and functional heterogeneity of GABAergic synapses". Cellular and Molecular Life Sciences 69 15 (2012): 2485-2499. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864353034&partnerID=MN8TOARS.
    10.1007/s00018-012-0926-4
  42. Farinelli, M.; Heitz, F.D.; Grewe, B.F.; Tyagarajan, S.K.; Helmchen, F.; Mansuy, I.M.. "Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859138345&partnerID=MN8TOARS.
    10.1371/journal.pone.0034047
  43. Tyagarajan, S.K.; Ghosh, H.; Yévenes, G.E.; Nikonenko, I.; Ebeling, C.; Schwerdel, C.; Sidler, C.; et al. "Regulation of GABAergic synapse formation and plasticity by GSK3ß-dependent phosphorylation of gephyrin". Proceedings of the National Academy of Sciences of the United States of America 108 1 (2011): 379-384. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651103907&partnerID=MN8TOARS.
    10.1073/pnas.1011824108
  44. Panzanelli, P.; Gunn, B.G.; Schlatter, M.C.; Benke, D.; Tyagarajan, S.K.; Scheiffele, P.; Belelli, D.; et al. "Distinct mechanisms regulate GABA A receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells". Journal of Physiology 589 20 (2011): 4959-4980. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054099531&partnerID=MN8TOARS.
    10.1113/jphysiol.2011.216028
  45. Tyagarajan, S.K.; Ghosh, H.; Harvey, K.; Fritschy, J.-M.. "Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses". Journal of Cell Science 124 16 (2011): 2786-2796. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961132249&partnerID=MN8TOARS.
    10.1242/jcs.086199
  46. Tyagarajan, S.K.; Fritschy, J.-M.. "GABAA receptors, gephyrin and homeostatic synaptic plasticity". Journal of Physiology 588 1 (2010): 101-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549114248&partnerID=MN8TOARS.
    10.1113/jphysiol.2009.178517
  47. Bollag, B.; Kilpatrick, L.H.; Tyagarajan, S.K.; Tevethia, M.J.; Frisque, R.J.. "JC virus T'135, T'136 and T'165 proteins interact with cellular p107 and p130 in vivo and influence viral transformation potential". Journal of NeuroVirology 12 6 (2006): 428-442. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845489472&partnerID=MN8TOARS.
    10.1080/13550280601009553
  48. Frisque RJ; Hofstetter C; Tyagarajan SK. "Transforming activities of JC virus early proteins.". (2006): http://europepmc.org/abstract/med/16626044.
  49. Tyagarajan, S.K.; Frisque, R.J.. "Stability and function of JC viras large T antigen and T' proteins are altered by mutation of their phosphorylated threonine 125 residues". Journal of Virology 80 5 (2006): 2083-2091. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144483491&partnerID=MN8TOARS.
    10.1128/JVI.80.5.2083-2091.2006
  50. Tyagarajan, Shiva K.; Frisque, Richard J.. "The stability and function of JC virus tumor proteins are influenced by mutations to amino acid residue threonine 125". Journal of Neurovirology 14 (2005): 43-43. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000205415200026&KeyUID=WOS:000205415200026.
  51. Frisque, Richard J.; Bam, Rujuta; Tyagarajan, Shiva K.; Tevethia, M. Judith. "T antigen isoforms of the human polyomaviruses". Journal of Neurovirology 14 (2005): 65-65. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000205415200048&KeyUID=WOS:000205415200048.
  52. Frisque, R. J.; Kilpatrick, L. H.; Tyagarajan, S. T.. "JC virus early proteins: Contributions to virus-host interactions". Journal of Neurovirology 14 (2004): 21-21. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000205415100014&KeyUID=WOS:000205415100014.
    10.1080/13550280490469653
  53. Frisque, RJ; Bollag, B; Tyagarajan, SK; Kilpatrick, LH. "T ' proteins influence JC virus biology". Journal of Neurovirology 9 (2003): 15-20. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000182795700004&KeyUID=WOS:000182795700004.
    10.1080/713831425
  54. Frisque RJ; Bollag B; Tyagarajan SK; Kilpatrick LH. "T' proteins influence JC virus biology.". (2003): http://europepmc.org/abstract/med/12709866.
  55. Frisque, R.J.; Bollag, B.; Tyagarajan, S.K.; Kilpatrick, L.H.. "T' proteins influence JC virus biology". Journal of NeuroVirology 9 SUPPL. 1 (2003): 15-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-18144441436&partnerID=MN8TOARS.
Capítulo de livro
  1. Frisque, RJ; Hofstetter, C; Tyagarajan, SK. "Transforming activities of JC virus early proteins". 288-309. 2006.
    10.1007/0-387-32957-9_21
Pré-impressão
  1. Diego Ortiz-López; Tamsanqa T. Hove; Christiane Huhn; Pia M. van gen Hassend; Bodo Sander; Benjamin F.N. Campbell; Shiva K. Tyagarajan; et al. "Cryo-EM Structures of Higher Order Gephyrin Oligomers Reveal Principles of Inhibitory Postsynaptic Scaffold Organization". 2025. https://doi.org/10.1101/2025.09.01.673457.
    10.1101/2025.09.01.673457

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  1. Neuroprotective tissue adaptation induced by IL-12 attenuates CNS inflammation. 2022. Andreadou, M.; Ingelfinger, F.; De Feo, D.; Friebel, E.; Tuzlak, S.; Cramer, T.M.L.; Schreiner, B.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85140358023&partnerID=MN8TOARS.
    10.1101/2022.09.14.506749
  2. Differential Impact of GABA A Receptors on Inhibitory Connectivity for Superficial Pyramidal Neuron Responsiveness In Vivo. 2020. Tsai, Y.-C.; Hleihil, M.; Cramer, T.; Ferrari, K.D.; Barrett, M.J.P.; Bosshard, G.; Weber, B.; Stobart, J.L.; Tyagarajan, S.K.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110200301&partnerID=MN8TOARS.
    10.2139/ssrn.3737104
  3. Differential impact of GABAA receptors and gephyrin post-translational modifications on layer 2/3 pyramidal neuron responsiveness in vivo. 2020. Tsai, Y.-C.; Hleihil, M.; Otomo, K.; Abegg, A.; Cavaccini, A.; Panzanelli, P.; Cramer, T.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85143916585&partnerID=MN8TOARS.
    10.1101/2020.11.25.397877
  4. Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia. 2020. Cramer, T.; Gill, R.; Thirouin, Z.S.; Vaas, M.; Sampath, S.; Noya, S.B.; Chang, P.K.-Y.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098910658&partnerID=MN8TOARS.
    10.1101/2020.04.22.055087
  5. Surfaceome dynamics during neuronal development and synaptic plasticity reveal system-wide surfaceome reorganization independent of global proteostasis. 2019. van Oostrum, M.; Campbell, B.; Müller, M.; Pedrioli, P.G.A.; Tyagarajan, S.K.; Wollscheid, B.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095497433&partnerID=MN8TOARS.
    10.1101/731083
  6. RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of a2 GABAA receptors. 2017. deGroot, C.; Floriou-Servou, A.; Tsai, Y.-C.; Früh, S.; Kohler, M.; Parkin, G.; Schwerdel, C.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095627330&partnerID=MN8TOARS.
    10.1101/197905