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Maria João Mascarenhas Saraiva received a BSc in Biology from the University of Porto, Portugal, in 1976, and an MSc in Biochemistry from the University of London, in 1978. Between 1980 and 1984, she did a PhD in biochemistry at the University of Porto, and qualified as Professor of Biochemistry in the University of Porto in 1991. She worked for different periods as a Visiting Scientist at the College of Physicians and Surgeons at Columbia University, New York. She is Director of the Molecular Neurobiology Group at i3S and IBMC in Porto University. Maria J Saraiva was awarded the Seiva Prize for Services to Science by the City of Porto, in 1996, the Gulbenkian Prize in Science, in 2009 and a National Medal for Merrit in Science in 2019. She has published over 230 articles in peer reviewed journals, several reviews on the subject of molecular biology of misfolding diseases of the central and peripheral nervous system.
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Identificação

Identificação pessoal

Nome completo
Maria João Gameiro de Mascarenhas Saraiva

Nomes de citação

  • Saraiva, Maria

Identificadores de autor

Ciência ID
8A1C-1740-5CD0
ORCID iD
0000-0002-3360-6899
Formação
Grau Classificação
1991
Concluído
 Biomedicas (Título de Agregado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Approved
1984
Concluído
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Presence of an abnormal transthyretin in familial amyloidotic polyneuropathy" (TESE/DISSERTAÇÃO)
 Com Louvor e Distinção
1978
Concluído
 Master of Science (Master)
University College London Department of Pharmaceutical and Biological Chemistry, Reino Unido
1976
Concluído
 Licenciatura pre´Bolonha in Biology (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1997/01/05 - Atual Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
1984/12/17 - 2014/03/01 Professor Catedrático (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1989 - 1993 Professor Associado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1984 - 1989 Professor Auxiliar (Docente Universitário) Universidad de Chile Instituto de Ciencias Biomédicas, Chile
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projetos

Bolsa

Designação Financiadores
2017 - 2020 New Targets in Diastolic heart failure: from coMorbities to personalized medicine
SAICTPAC/00472015
Outra
Em curso
2013/07 - 2015/06 Molecular mechanisms in the clearance of protein aggregates in misfolding disorders
124532
Provided by PTCRIS: 124532
 Fundação para a Ciência e a Tecnologia, I.P.
2009/01 - 2011/03 Therapies in familial amyloidotic polyneuropathy
Provided by PTCRIS: 82824
82824
 Fundação para a Ciência e a Tecnologia, I.P.
2007/11 - 2010/10 Search for the molecular basis of transthyretin involvement in the biology of the nervous system.
64437
Provided by PTCRIS: 64437
 Fundação para a Ciência e a Tecnologia, I.P.
2007/10 - 2010/06 Growth factors in health and disease
Provided by PTCRIS: 64093
64093
 Fundação para a Ciência e a Tecnologia, I.P.
2007/08 - 2009/12 Modulation of A-Beta toxicity by transthyretin in AlZheimer´s disease
Provided by PTCRIS: 111313
111313
 Fundação para a Ciência e a Tecnologia, I.P.
2007/08 - 2009/12 Modulation of A-Beta toxicity by transthyretin in AlZheimer´s disease
Provided by PTCRIS: 64593
64593
 Fundação para a Ciência e a Tecnologia, I.P.
2007/10 - 2008/11 Characterization of toxicity cascades in transthyretin-related amyloidoses
82351
Provided by PTCRIS: 82351
 Fundação para a Ciência e a Tecnologia, I.P.
2005/08 - 2008/01 Role of Transthyretin in A-Beta toxicity
Provided by PTCRIS: 57761
57761
 Fundação para a Ciência e a Tecnologia, I.P.
2005/09 - 2007/10 Molecular pathology of familial amyloid polyneuropathy
56929
Provided by PTCRIS: 56929
 Fundação para a Ciência e a Tecnologia, I.P.
1987/09 - 1990/08 TRANSTHYRETIN AND HEREDITARY AMYLOID NEUROPATHY
5R01NS025190-03
 National Institute of Neurological Disorders and Stroke

Outro

Designação Financiadores
2017 - 2020 Porto Neurosciences and Neurologic Disease Initiative at Institute for Research and Innovation in Health Sciences
POCI-01-0145-FEDER 000008
Outra
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Concluído
2017 - 2020 NEUROTERA- Para a introdução no mercado de novos agentes terapeuticos contra co-morbilidades e cerebrais
POCI-01-0247-FEDER-003431
Outra
Agência Nacional de Inovação SA
Concluído
Produções

Publicações

Artigo em revista
  1. Moreira, J.; Martins, S.; Saraiva, M.; Saraiva, M.J.. "Decreased expression of S100A8/A9 in V30M related ATTRv amyloidosis". Amyloid 30 3 (2023): 327-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-85150889258&partnerID=MN8TOARS.
    10.1080/13506129.2023.2185755
  2. Teixeira, A.C.; Saraiva, M.J.. "Selective recognition of human small transthyretin aggregates by a novel monoclonal antibody". Amyloid 30 1 (2023): 74-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-85138264668&partnerID=MN8TOARS.
    10.1080/13506129.2022.2122034
  3. Moreira, J.; Martins, H.; Saraiva, M.; João Saraiva, M.. "TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines". Clinical Science 137 5 (2023): 355-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-85150001061&partnerID=MN8TOARS.
    10.1042/CS20220656
  4. Teixeira, C.; Martins, H.S.; Saraiva, M.J.. "Cellular environment of TTR deposits in an animal model of ATTR—Cardiomyopathy". Frontiers in Molecular Biosciences 10 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85150717436&partnerID=MN8TOARS.
    10.3389/fmolb.2023.1144049
  5. Buxbaum, J.N.; Dispenzieri, A.; Eisenberg, D.S.; Fändrich, M.; Merlini, G.; Saraiva, M.J.M.; Sekijima, Y.; Westermark, P.. "Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee". Amyloid 29 4 (2022): 213-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142637364&partnerID=MN8TOARS.
    10.1080/13506129.2022.2147636
  6. Salazar, I.L.; Lourenço, A.S.T.; Manadas, B.; Baldeiras, I.; Ferreira, C.; Teixeira, A.C.; Mendes, V.M.; et al. "Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis". Journal of Neuroinflammation 19 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85124466899&partnerID=MN8TOARS.
    10.1186/s12974-022-02404-2
  7. Bezerra, F.; Niemietz, C.; Schmidt, H.H.J.; Zibert, A.; Guo, S.; Monia, B.P.; Gonçalves, P.; Saraiva, M.J.; Almeida, M.R.. "In vitro and in vivo effects of SerpinA1 on the modulation of transthyretin proteolysis". International Journal of Molecular Sciences 22 17 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85114018847&partnerID=MN8TOARS.
    10.3390/ijms22179488
  8. Michalon, A.; Hagenbuch, A.; Huy, C.; Varela, E.; Combaluzier, B.; Damy, T.; Suhr, O.B.; et al. "A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells". Nature Communications 12 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106879802&partnerID=MN8TOARS.
    10.1038/s41467-021-23274-x
  9. Moreira, J.; Costelha, S.; Saraiva, M.; Saraiva, M.J.. "The Expression of Chemokines Is Downregulated in a Pre-Clinical Model of TTR V30M Amyloidosis". Frontiers in Immunology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107221502&partnerID=MN8TOARS.
    10.3389/fimmu.2021.650269
  10. Bezerra, Filipa; Saraiva, Maria João; Almeida, Maria Rosário. "Modulation of the Mechanisms Driving Transthyretin Amyloidosis". Frontiers in Molecular Neuroscience 13 (2020): http://dx.doi.org/10.3389/fnmol.2020.592644.
    Acesso aberto • Aceite para publicação • 10.3389/fnmol.2020.592644
  11. Maia, Luis F.; Maceski, Aleksandra; Conceição, Isabel; Obici, Laura; Magalhães, Rui; Cortese, Andreas; Leppert, David; et al. "Plasma neurofilament light chain: an early biomarker for hereditary ATTR amyloid polyneuropathy". Amyloid 27:2, 97-102 27 2 (2020): 97-102. http://dx.doi.org/10.1080/13506129.2019.1708716.
    Acesso aberto • Publicado • 10.1080/13506129.2019.1708716
  12. Gomes, João R; Lobo, Andrea; Nogueira, Renata; Terceiro, Ana F; Costelha, Susete; Lopes, Igor M; Magalhães, Ana; Summavielle, Teresa; Saraiva, Maria J. "Neuronal megalin mediates synaptic plasticity—a novel mechanism underlying intellectual disabilities in megalin gene pathologies". Brain Communications 2 2 (2020): http://dx.doi.org/10.1093/braincomms/fcaa135.
    Acesso aberto • 10.1093/braincomms/fcaa135
  13. Benson, M.D.; Buxbaum, J.N.; Eisenberg, D.S.; Merlini, G.; Saraiva, M.J.M.; Sekijima, Y.; Sipe, J.D.; Westermark, P.. "Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee". Amyloid 27 4 (2020): 217-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85094144207&partnerID=MN8TOARS.
    10.1080/13506129.2020.1835263
  14. Talhada, D.; Gonçalves, I.; Gomes, J.C.; Saraiva, M.J.; Santos, C.R.; Ruscher, K.. "Erratum : Transthyretin expression in the postischemic brain (PLoS ONE 14:9 Doi: 10.1371/journal.pone.0221555)". PLoS ONE 15 6 June (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087100324&partnerID=MN8TOARS.
    10.1371/journal.pone.0235527
  15. Niemietz, C.; Bezerra, F.; Almeida, M.R.; Guo, S.; Monia, B.P.; Saraiva, M.J.; Schütz, P.; Schmidt, H.H.-J.; Zibert, A.. "SERPINA1 modulates expression of amyloidogenic transthyretin". Experimental Cell Research 395 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85089180606&partnerID=MN8TOARS.
    10.1016/j.yexcr.2020.112217
  16. Gomes, J.R.; Sárkány, Z.; Teixeira, A.; Nogueira, R.; Cabrito, I.; Soares, H.; Wittelsberger, A.; et al. "Anti-TTR Nanobodies Allow the Identification of TTR Neuritogenic Epitope Associated with TTR-Megalin Neurotrophic Activities". ACS Chemical Neuroscience 10 1 (2019): 704-715. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055702609&partnerID=MN8TOARS.
    10.1021/acschemneuro.8b00502
  17. Ferreira, N.; Saraiva, M.J.; Almeida, M.R.. "Uncovering the neuroprotective mechanisms of curcumin on transthyretin amyloidosis". International Journal of Molecular Sciences 20 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85062979338&partnerID=MN8TOARS.
    10.3390/ijms20061287
  18. Bezerra, F.; Simões, C.J.V.; Beirão, J.M.; Saraiva, M.J.; Brito, R.M.M.; Almeida, M.R.. "Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous". Amyloid 26 sup1 (2019): 73-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069628713&partnerID=MN8TOARS.
    10.1080/13506129.2019.1583193
  19. Moreira, J.; Saraiva, M.; Saraiva, M.J.. "Downregulated Cathepsin E expression in bone marrow-derived macrophages from the pre-clinical familial amyloid polyneuropathy model". Amyloid 26 sup1 (2019): 63-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069677766&partnerID=MN8TOARS.
    10.1080/13506129.2019.1585342
  20. Simões, C.J.V.; Almeida, Z.L.; Cardoso, A.L.; Bezerra, F.; Almeida, M.R.; Beirão, J.; Pinho e Melo, T.M.V.D.; Saraiva, M.J.; Brito, R.M.M.. "Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS". Amyloid 26 sup1 (2019): 77-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069666459&partnerID=MN8TOARS.
    10.1080/13506129.2019.1583195
  21. Benson, M.D.; Buxbaum, J.N.; Eisenberg, D.S.; Merlini, G.; Saraiva, M.J.M.; Sekijima, Y.; Sipe, J.D.; Westermark, P.. "Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee". Amyloid 25 4 (2018): 215-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059621827&partnerID=MN8TOARS.
    10.1080/13506129.2018.1549825
  22. Gomes, J.R.; Cabrito, I.; Soares, H.R.; Costelha, S.; Teixeira, A.; Wittelsberger, A.; Stortelers, C.; Vanlandschoot, P.; Saraiva, M.J.. "Delivery of an anti-transthyretin Nanobody to the brain through intranasal administration reveals transthyretin expression and secretion by motor neurons". Journal of Neurochemistry 145 5 (2018): 393-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046672101&partnerID=MN8TOARS.
    10.1111/jnc.14332
  23. Lopes, C.D.F.; Gonçalves, N.P.; Gomes, C.P.; Saraiva, M.J.; Pêgo, A.P.. "BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury". Biomaterials 121 (2017): 83-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008958194&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2016.12.025
  24. Sant'Anna, R.; Almeida, M.R.; Varejao, N.; Gallego, P.; Esperante, S.; Ferreira, P.; Pereira-Henriques, A.; et al. "Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85016162023&partnerID=MN8TOARS.
    10.1038/srep44709
  25. Pires, R.H.; Saraiva, M.J.; Damas, A.M.; Kellermayer, M.S.Z.. "Force spectroscopy reveals the presence of structurally modified dimers in transthyretin amyloid annular oligomers". Journal of Molecular Recognition 30 3 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-84996636689&partnerID=MN8TOARS.
    10.1002/jmr.2587
  26. Martins, D.; Moreira, J.; Gonçalves, N.P.; Saraiva, M.J.. "MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy". DMM Disease Models and Mechanisms 10 10 (2017): 1253-1260. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031771832&partnerID=MN8TOARS.
    10.1242/dmm.028571
  27. Panayiotou, E.; Fella, E.; Papacharalambous, R.; Malas, S.; Saraiva, M.J.; Kyriakides, T.. "C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy". PLoS ONE 12 4 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85017528439&partnerID=MN8TOARS.
    10.1371/journal.pone.0175767
  28. Gonçalves, N.P.; Martins, D.; Saraiva, M.J.. "The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers". Amyloid 24 (2017): 83-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018728032&partnerID=MN8TOARS.
    10.1080/13506129.2016.1278362
  29. Gonçalves, N.P.; Moreira, J.; Martins, D.; Vieira, P.; Obici, L.; Merlini, G.; Saraiva, M.; Saraiva, M.J.. "Differential expression of Cathepsin E in transthyretin amyloidosis: From neuropathology to the immune system". Journal of Neuroinflammation 14 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020206626&partnerID=MN8TOARS.
    10.1186/s12974-017-0891-9
  30. Teixeira, C.; Costelha, S.; Martins, H.S.; Teixeira, A.; Saraiva, M.J.. "Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model". Amyloid 24 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018742465&partnerID=MN8TOARS.
    10.1080/13506129.2016.1277695
  31. Gonçalves, P.; Martins, H.; Costelha, S.; Saraiva, M.J.. "Efficiency of siRNA for removal of transthyretin V30M in a TTR leptomeningeal animal model". Amyloid 24 (2017): 38-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018761744&partnerID=MN8TOARS.
    10.1080/13506129.2016.1272452
  32. Pansieri, J.; Plissonneau, M.; Stransky-Heilkron, N.; Dumoulin, M.; Heinrich-Balard, L.; Rivory, P.; Morfin, J.-F.; et al. "Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting". Nanomedicine 12 14 (2017): 1675-1687. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022183682&partnerID=MN8TOARS.
    10.2217/nnm-2017-0079
  33. Gonçalves, N.P.; Martins, D.; Saraiva, M.J.. "Overexpression of Protocadherin-10 in Transthyretin-Related Familial Amyloidotic Polyneuropathy". American Journal of Pathology 186 7 (2016): 1913-1924. http://www.scopus.com/inward/record.url?eid=2-s2.0-84997207695&partnerID=MN8TOARS.
    10.1016/j.ajpath.2016.02.020
  34. Gomes, J.R.; Nogueira, R.S.; Vieira, M.; Santos, S.D.; Ferraz-Nogueira, J.P.; Relvas, J.B.; Saraiva, M.J.. "Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia". Cell Death and Differentiation 23 11 (2016): 1749-1764. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982105742&partnerID=MN8TOARS.
    10.1038/cdd.2016.64
  35. Plissonneau, M.; Pansieri, J.; Heinrich-Balard, L.; Morfin, J.-F.; Stransky-Heilkron, N.; Rivory, P.; Mowat, P.; et al. "Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting". Journal of Nanobiotechnology 14 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84979272576&partnerID=MN8TOARS.
    10.1186/s12951-016-0212-y
  36. Gonçalves, N.P.; Gonçalves, P.; Magalhães, J.; Ventosa, M.; Coelho, A.V.; Saraiva, M.J.. "Tissue remodeling after interference RNA mediated knockdown of transthyretin in a familial amyloidotic polyneuropathy mouse model". Neurobiology of Aging 47 (2016): 91-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983775600&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2016.07.020
  37. Ferreira, N.; Gonçalves, N.P.; Saraiva, M.J.; Almeida, M.R.. "Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin amyloidosis". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84969921377&partnerID=MN8TOARS.
    10.1038/srep26623
  38. Gonçalves, P.; Martins, H.; Costelha, S.; Maia, L.F.; Saraiva, M.J.. "Efficiency of silencing RNA for removal of transthyretin V30M in a TTR leptomeningeal animal model". Amyloid 23 4 (2016): 249-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-84997124349&partnerID=MN8TOARS.
    10.1080/13506129.2016.1256282
  39. Simões, C.J.V.; Almeida, Z.L.; Costa, D.; Jesus, C.S.H.; Cardoso, A.L.; Almeida, M.R.; Saraiva, M.J.; Pinho e Melo, T.M.V.D.; Brito, R.M.M.. "A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition". European Journal of Medicinal Chemistry 121 (2016): 823-840. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961839171&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.02.074
  40. Sipe, J.D.; Benson, M.D.; Buxbaum, J.N.; Ikeda, S.-I.; Merlini, G.; Saraiva, M.J.M.; Westermark, P.. "Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines". Amyloid 23 4 (2016): 209-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84997221695&partnerID=MN8TOARS.
    10.1080/13506129.2016.1257986
  41. Teixeira, C.A.; Almeida, M.d.R.; Saraiva, M.J.. "Impairment of autophagy by TTR V30M aggregates: In vivo reversal by TUDCA and curcumin". Clinical Science 130 18 (2016): 1665-1675. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014362637&partnerID=MN8TOARS.
    10.1042/CS20160075
  42. Butler, J.S.; Chan, A.; Costelha, S.; Fishman, S.; Willoughby, J.L.S.; Borland, T.D.; Milstein, S.; et al. "Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis". Amyloid 23 2 (2016): 109-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962124696&partnerID=MN8TOARS.
    10.3109/13506129.2016.1160882
  43. Vieira, M.; Leal, S.S.; Gomes, C.M.; Saraiva, M.J.. "Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor". Biochimica et Biophysica Acta - Molecular Basis of Disease 1862 4 (2016): 797-804. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958526939&partnerID=MN8TOARS.
    10.1016/j.bbadis.2016.01.008
  44. Alemi, M.; Gaiteiro, C.; Ribeiro, C.A.; Santos, L.M.; Gomes, J.R.; Oliveira, S.M.; Couraud, P.-O.; et al. "Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84957818760&partnerID=MN8TOARS.
    10.1038/srep20164
  45. Conejos-Sánchez, I.; Cardoso, I.; Oteo-Vives, M.; Romero-Sanz, E.; Paul, A.; Sauri, A.R.; Morcillo, M.A.; Saraiva, M.J.; Vicent, M.J.. "Polymer-doxycycline conjugates as fibril disrupters: An approach towards the treatment of a rare amyloidotic disease". Journal of Controlled Release 198 (2015): 80-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-84917690965&partnerID=MN8TOARS.
    10.1016/j.jconrel.2014.12.003
  46. Gonçalves, N.P.; Teixeira-Coelho, M.; Saraiva, M.J.. "Protective role of anakinra against transthyretin-mediated axonal loss and cell death in a mouse model of familial amyloidotic polyneuropathy". Journal of Neuropathology and Experimental Neurology 74 3 (2015): 203-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923701097&partnerID=MN8TOARS.
    10.1097/NEN.0000000000000164
  47. Vieira, M.; Gomes, J.R.; Saraiva, M.J.. "Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the Hippocampus". Molecular Neurobiology 51 3 (2015): 1468-1479. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939882016&partnerID=MN8TOARS.
    10.1007/s12035-014-8824-4
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  228. de Fatima Torres, M.; do Rosário Almeida, M.; Saraiva, M.J.. "TTR exon scanning in peripheral neuropathies". Neuromuscular Disorders 5 3 (1995): 187-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029020077&partnerID=MN8TOARS.
  229. Jacobson, D.R.; Alves, I.L.; Saraiva, M.J.; Thibodeau, S.N.; Buxbaum, J.N.. "Transthyretin Ser 6 gene frequency in individuals without amyloidosis". Human Genetics 95 3 (1995): 308-312. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028910933&partnerID=MN8TOARS.
    10.1007/BF00225199
  230. Saraiva, M.J.M.. "Transthyretin mutations in health and disease". Human Mutation 5 3 (1995): 191-196. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028969996&partnerID=MN8TOARS.
    10.1002/humu.1380050302
  231. Damas, A.; Sebastiato, M.P.; Domingues, F.S.; Costae, P.P.; Saraiva, M.J.. "Structural studies on FAP fibrils: Removal of contaminants is essential for the interpretation of x-ray data". Amyloid 2 3 (1995): 173-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001747637&partnerID=MN8TOARS.
    10.3109/13506129509036922
  232. Almeida, M.R.; Saraiva, M.J.. "TTR leu 64 in an FAP kindred identified by PCR-RFLP analysis". Amyloid 1 3 (1994): 184-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028082978&partnerID=MN8TOARS.
    10.3109/13506129409148450
  233. Palha, J.A.; Episkopou, V.; Maeda, S.; Shimada, K.; Gottesman, M.E.; Saraiva, M.J.M.. "Thyroid hormone metabolism in a transthyretin-null mouse strain". Journal of Biological Chemistry 269 52 (1994): 33135-33139. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028596483&partnerID=MN8TOARS.
  234. Holmgren, G.; Costa, P.M.P.; Andersson, C.; Asplund, K.; Steen, L.; Beckman, L.; Nylander, P.-O.; et al. "Geographical distribution of TTR met30 carriers in northern Sweden: Discrepancy between carrier frequency and prevalence rate". Journal of Medical Genetics 31 5 (1994): 351-354. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028200952&partnerID=MN8TOARS.
    10.1136/jmg.31.5.351
  235. Almeida, M.D.R.; Lopez-Andreu, F.; Munar-Qués, M.; Costa, P.P.; Saraiva, M.J.. "Transthyretin ALA 71: A new transthyretin variant in a Spanish family with familial amyloidotic polyneuropathy". Human Mutation 2 5 (1993): 420-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027495964&partnerID=MN8TOARS.
  236. Alves, I.L.; Divino, C.M.; Schussler, G.C.; Altland, K.; Almeida, M.R.; Palha, J.A.; Coelho, T.; Costa, P.P.; Saraiva, M.J.M.. "Thyroxine binding in a TTR Met 119 kindred". Journal of Clinical Endocrinology and Metabolism 77 2 (1993): 484-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027240115&partnerID=MN8TOARS.
  237. Terry, C.J.; Damas, A.M.; Oliveira, P.; Saraiva, M.J.M.; Alves, I.L.; Costa, P.P.; Matias, P.M.; Sakaki, Y.; Blake, C.C.F.. "Structure of Met30 variant of transthyretin and its amyloidogenic implications". EMBO Journal 12 2 (1993): 735-741. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027518443&partnerID=MN8TOARS.
  238. Bonifácio, M.J.; Ezzeddine, D.; Sakaki, Y.; Breakfield, X.O.; Saraiva, M.J.. "Retrovirus-mediated gene transfer of transthyretin and transthyretin-methionine 30: A potential tool for the study of amyloidogenesis". Neuromuscular Disorders 3 4 (1993): 275-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027362792&partnerID=MN8TOARS.
  239. Costa, P.M.P.; Teixeira, A.; Saraiva, M.J.M.; Costa, P.P.. "Immunoassay for transthyretin variants associated with amyloid neuropathy". Scandinavian Journal of Immunology 38 2 (1993): 177-182. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027244022&partnerID=MN8TOARS.
    10.1111/j.1365-3083.1993.tb01710.x
  240. Hesse, A.; Altland, K.; Linke, R.P.; Almeida, M.R.; Saraiva, M.J.M.; Steinmetz, A.; Maisch, B.. "Cardiac amyloidosis: A review and report of a new transthyretin (prealbumin) variant". British Heart Journal 70 2 (1993): 111-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027170502&partnerID=MN8TOARS.
  241. Alves, I.L.; Almeida, M.R.; Skare, J.; Skinner, M.; Kurose, K.; Sakaki, Y.; Costa, P.P.; Saraiva, M.J.M.. "Amyloidogenic and non-amyloidogenic transthyretin Asn 90 variants". Clinical Genetics 42 1 (1992): 27-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026691223&partnerID=MN8TOARS.
    10.1111/j.1399-0004.1992.tb03131.x
  242. Saraiva, M.J.M.; Almeida, M.D.R.; Sherman, W.; Gawinowicz, M.; Costa, P.; Costa, P.P.; Goodman, D.S.. "A new transthyretin mutation associated with amyloid cardiomyopathy". American Journal of Human Genetics 50 5 (1992): 1027-1030. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026724677&partnerID=MN8TOARS.
  243. Ranløv, I.; Alves, I.L.; Ranløv, P.J.; Husby, G.; Costa, P.P.; Saraiva, M.J.M.. "A Danish kindred with familial amyloid cardiomyopathy revisited: Identification of a mutant transthyretin-methionine111 variant in serum from patients and carriers". American Journal of Medicine 93 1 (1992): 3-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026753618&partnerID=MN8TOARS.
    10.1016/0002-9343(92)90672-X
  244. Do Rosário Almeida, M.; Ferlini, A.; Forabosco, A.; Gawinowicz, M.; Costa, P.P.; Salvi, F.; Plasmati, R.; et al. "Two transthyretin variants (TTR ala-49 and TTR gin-89) in two sicilian kindreds with hereditary amyloidosis". Human Mutation 1 3 (1992): 211-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027023491&partnerID=MN8TOARS.
    10.1002/humu.1380010306
  245. Regnault, V.; Costa, P.M.P.; Teixeira, A.; Rivat, C.; Stoltz, J.F.; Saraiva, M.J.M.; Costa, P.P.. "Specific removal of transthyretin from plasma of patients with familial amyloidotic polyneuropathy: Optimization of an immunoadsorption procedure". International Journal of Artificial Organs 15 4 (1992): 249-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026596514&partnerID=MN8TOARS.
  246. Almeida, M.R.; Hesse, A.; Steinmetz, A.; Maisch, B.; Altland, K.; Linker, R.P.; Gawinowicz, M.A.; Saraiva, M.J.M.. "Transthyretin Leu 68 in a form of cardiac amyloidosis". Basic Research in Cardiology 86 6 (1991): 567-571. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026331577&partnerID=MN8TOARS.
    10.1007/BF02190707
  247. Blaner, W.S.; Bonifácio, M.J.; Feldman, H.D.; Piantedosi, R.; Saraiva, M.J.M.. "Studies on the synthesis and secretion of transthyretin by the human hepatoma cell line Hep G2". FEBS Letters 287 1-2 (1991): 193-196. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025744832&partnerID=MN8TOARS.
  248. Saraiva, M.J.M.. "Recent advances in the molecular pathology of familial amyloid polyneuropathy". Neuromuscular Disorders 1 1 (1991): 3-6. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026042980&partnerID=MN8TOARS.
  249. Guilherme Monteiro, J.; Martins, A.F.F.; Figueira, A.; Saraiva, M.J.M.; Pinho Costa, P.. "Ocular changes in familial amyloidotic polyneuropathy with dense vitreous opacities". Eye 5 1 (1991): 99-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025884709&partnerID=MN8TOARS.
  250. Saraiva, M.J.M.; Almeida, M.D.R.; Alves, I.L.; Moreira, P.; Gawinowicz, M.; Costa, P.P.; Rauh, S.; Banhzoff, A.; Altland, K.. "Molecular analyses of an acidic transthyretin Asn 90 variant". American Journal of Human Genetics 48 5 (1991): 1004-1008. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025853733&partnerID=MN8TOARS.
  251. do Rosário Almeda, M.; Altland, K.; Rauh, S.; Gawinowicz, M.; Moreira, P.; Pinho Costa, P.; João Saraiva, M.. "Characterization of a basic transthyretin variant - TTR Arg 102 - in the German population". BBA - Molecular Basis of Disease 1097 3 (1991): 224-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025939510&partnerID=MN8TOARS.
  252. Monteiro, J.G.; Martins, A.F.F.; Figueira, A.; Saraiva, M.J.M.; Costa, P.P.. "Ocular changes in familial amyloidotic polyneuropathy with dense vitreous opacities". Eye (Basingstoke) 5 1 (1991): 99-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966163164&partnerID=MN8TOARS.
    10.1038/eye.1991.19
  253. Saraiva, M.M.; Saraiva, A.M.. "Anal tonometry: A quick method of anal manometry". Diseases of the Colon & Rectum 34 5 (1991): 396-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025890004&partnerID=MN8TOARS.
    10.1007/BF02053690
  254. Furuya, H.; Saraiva, M.J.M.; Alves, I.L.; Gawinowicz, M.A.; Costa, P.P.; Sasaki, H.; Goto, I.; Sakaki, Y.. "Production of Recombinant Human Transthyretin with Biological Activities toward the Understanding of the Molecular Basis of Familial Amyloidotic Polyneuropathy (FAP)". Biochemistry 30 9 (1991): 2415-2421. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025825160&partnerID=MN8TOARS.
    10.1021/bi00223a017
  255. SAraiva, M.J.M.; Sherman, W.; Marboe, C.; Figueira, A.; Costa, P.; De Freitas, A.F.; Gawinowicz, M.A.. "Cardiac amyloidosis: Report of a patient heterozygous for the transthyretin isoleucine 122 variant". Scandinavian Journal of Immunology 32 4 (1990): 341-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025169627&partnerID=MN8TOARS.
    10.1111/j.1365-3083.1990.tb02928.x
  256. Furuya, H.; Nakazato, M.; Saraiva, M.J.M.; Costa, P.P.; Sasaki, H.; Matsuo, H.; Goto, I.; Sakaki, Y.. "Tetramer formation of a variant type human transthyretin (prealbumin) produced by Escherichia coli expression system". Biochemical and Biophysical Research Communications 163 2 (1989): 851-859. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024455085&partnerID=MN8TOARS.
  257. Mascarenhas Saraiva, M.J.; Longo Alves, I.; Costa, P.P.. "Simplified method for screening populations at risk for transthyretin Met30-associated familial amyloidotic polyneuropathy". Clinical Chemistry 35 6 (1989): 1033-1035. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024392663&partnerID=MN8TOARS.
    10.1093/clinchem/35.6.1033
  258. Yoshioka, K.; Furuya, H.; Sasaki, H.; Saraiva, M.J.M.; Costa, P.P.; Sakaki, Y.. "Haplotype analysis of familial amyloidotic polyneuropathy - Evidence for multiple origins of the Val¿Met mutation most common to the disease". Human Genetics 82 1 (1989): 9-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024538761&partnerID=MN8TOARS.
    10.1007/BF00288262
  259. Sasaki, H.; Nakazato, M.; Saraiva, M.J.M.; Matsuo, H.; Sakaki, Y.. "Activity of a metallothionein-transthyretin fusion gene in transgenic mice. Possible effect of plasmid sequences on tissue-specific expression". Molecular Biology and Medicine 6 4 (1989): 345-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024957551&partnerID=MN8TOARS.
  260. Skare, J.C.; Saraiva, M.J.M.; Alves, I.L.; Skare, I.B.; Milunsky, A.; Cohen, A.S.; Skinner, M.. "A new mutation causing familial amyloidotic polyneuropathy". Biochemical and Biophysical Research Communications 164 3 (1989): 1240-1246. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024437903&partnerID=MN8TOARS.
  261. Goodman, D.S.; Saraiva, M.J.. "Reply from the authors". Neurology 38 3 (1988): http://www.scopus.com/inward/record.url?eid=2-s2.0-84947644291&partnerID=MN8TOARS.
  262. Saraiva, M.J.M.; Costa, P.P.; Almeida, M.d.R.; Banzhoff, A.; Altland, K.; Ferlini, A.; Rubboli, G.; et al. "Familial amyloidotic polyneuropathy: transthyretin (prealbumin) variants in kindreds of Italian origin". Human Genetics 80 4 (1988): 341-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024232963&partnerID=MN8TOARS.
    10.1007/BF00273648
  263. Ferlini, A.; Romeo, G.; Tassinari, C.A.; Saraiva, M.J.; Costa, P.P.; Salvi, F.. "Discrimination of peripheral polyneuropathies caused by TTR variant or diabetes in the same pedigree through protein studies.". Advances in neurology 48 (1988): 201-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023704327&partnerID=MN8TOARS.
  264. Saraiva, M.J.; Costa, P.P.; Goodman, D.S.. "Transthyretin (prealbumin) in familial amyloidotic polyneuropathy: genetic and functional aspects.". Advances in neurology 48 (1988): 189-200. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023742109&partnerID=MN8TOARS.
  265. Makover, A.; Moriwaki, H.; Ramakrishnan, R.; Saraiva, M.J.M.; Blaner, W.S.; Goodman DeWitt, S.. "Plasma transthyretin. Tissue sites of degradation and turnover in the rat". Journal of Biological Chemistry 263 18 (1988): 8598-8603. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023928530&partnerID=MN8TOARS.
  266. Munar-Qués, M.; Costa, P.P.; Saraiva, M.J.; Viader-Farré, C.; Munar-Bernat, C.. "Familial type I (Portuguese form) amyloidotic polyneuropathy in Majorca. Study using the TTR (Met30) genetic marker | Polineuropatía amiloidótica familiar tipo I forma portuguesa en Mallorca. Estudio por medio del marcador genético TTR (Met30).". Medicina clinica 91 12 (1988): 441-444. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024289015&partnerID=MN8TOARS.
  267. Sequeiros, J.; Mascarenhas Saraiva, M.J.. "Onset in the seventh decade and lack of symptoms in heterozygotes for the TTR(Met30) mutation in hereditary amyloid neuropathy - Type I (Portuguese, Andrade)". American Journal of Medical Genetics 27 2 (1987): 345-357. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023254244&partnerID=MN8TOARS.
  268. Saraiva, M.J.M.; Sherman, W.; Goodman, D.S.. "Presence of a plasma transthyretin (prealbumin) variant in familial amyloidotic polyneuropathy in a kindred of Greek origin". The Journal of Laboratory and Clinical Medicine 108 1 (1986): 11-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-46149133710&partnerID=MN8TOARS.
  269. Saraiva, M.J.M.; Sherman, W.; Goodman, D.S.. "Presence of a plasma transthyretin (prealbumin) variant in familial amyloidotic polyneuropathy in a kindred of Greek origin". Journal of Laboratory and Clinical Medicine 108 1 (1986): 17-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022536160&partnerID=MN8TOARS.
  270. Mascarenhas Saraiva, M.J.; Costa, P.P.; Goodman, D.S.. "Genetic expression of a transthyretin mutation in typical and late-onset Portuguese families with familial amyloidotic polyneuropathy". Neurology 36 11 (1986): 1413-1417. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023002761&partnerID=MN8TOARS.
    10.1212/wnl.36.11.1413
  271. Saraiva, M.J.M.; Costa, P.P.; Goodman, D.S.. "Biochemical marker in familial amyloidotic polyneuropathy, Portuguese type. Family studies on the transthyretin (prealbumin)-methionine-30 variant". Journal of Clinical Investigation 76 6 (1985): 2171-2177. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022338373&partnerID=MN8TOARS.
  272. Joao Mascarenhas Saraiva, M.; Birken, S.; Costa, P.P.; Goodman, D.S.. "Family studies of the genetic abnormality in transthyretin (prealbumin) in Portuguese patients with familial amyloidotic polyneuropathy". Annals of the New York Academy of Sciences VOL. 435 (1984): 86-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021667431&partnerID=MN8TOARS.
    10.1111/j.1749-6632.1984.tb13742.x
  273. Mascarenhas Saraiva, M.J.; Birken, S.; Costa, P.P.; Goodman, D.S.. "Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin)". Journal of Clinical Investigation 74 1 (1984): 104-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021266985&partnerID=MN8TOARS.
  274. Saraiva, M.J.M.; Costa, P.P.; Goodman, D.S.. "Studies on plasma transthyretin (prealbumin) in familial amyloidotic polyneuropathy, Portuguese type". The Journal of Laboratory and Clinical Medicine 102 4 (1983): 590-603. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020524650&partnerID=MN8TOARS.
  275. Saraiva, M.J.; Costa, P.P.; Birken, S.; Goodman, D.S.. "Presence of an abnormal transthyretin (prealbumin) in Portuguese patients with familial amyloidotic polyneuropathy.". Transactions of the Association of American Physicians 96 (1983): 261-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020924805&partnerID=MN8TOARS.
Capítulo de livro
  1. Sousa, M.M.; Amaral, J.B.; Guimarães, A.; Saraiva, M.J.. "Upregulation of the extracellular matrix remodeling genes, biglycan, neutrophil gelatinase-associated lipocalin and matrix metalloproteinase-9 in familial amyloid polyneuropathy". 320-322. 2004.
  2. Neto-Da-Silva, R.; Pereira, P.J.B.; Saraiva, M.J.M.; Damas, A.M.. "The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe". 326-328. 2004.
  3. Morais-De-Sá, E.; Pereira, P.J.B.; Saraiva, M.J.; Damas, A.M.. "The binding of diethylstilbestrol to transthyretin – a crystallographic model". 303-305. 2004.
  4. Almeida, M.R.; Macedo, B.; Cardoso, I.; Valencia, G.; Arsequell, G.; Planas, A.; Saraiva, M.J.. "Effects of a new diflunisal derivative on transthyretin binding and stabilization in serum from FAP patients". 497-499. 2004.
  5. Saraiva, M.J.. "Molecular and cellular aspects in transthyretin amyloidosis". 297-299. 2004.
  6. Mairal, T.; Arsequell, G.; Valencia, G.; Dolado, I.; Nieto, J.; Planas, A.; Barluenga, J.; et al. "Identification of new diflunisal derivatives as potent in vitro transthyretin fibril inhibitors". 505-507. 2004.
  7. Palladini, G.; Saraiva, M.J.; Perlini, S.; Obici, L.; Vezzoli, M.; Coelho, T.; Reis, H.; et al. "Amyloid-induced myocardial dysfunction depends on biochemical characteristics of the amyloidogenic protein". 70-72. 2004.
  8. Sousa, M.M.; Ferrão, J.; Fernandes, R.; Guimarães, A.; Geraldes, J.B.; Perdigoto, R.; Tomé, L.; et al. "Deposition and passage of transthyretin through the blood-nerve barrier in recipients of familial amyloid polyneuropathy livers". 357-359. 2004.
  9. Saraiva, Maria. "A TTR ACIDIC VARIANT DNA ANALYSIS OF HOMOZYGOUS AND HETEROZYGOUS INDIVIDUALS". 1991.
Livro
  1. Jesus, C.S.H.; Vaz, D.C.; Saraiva, M.J.M.; Brito, R.M.M.. The V30M amyloidogenic mutation decreases the rate of refolding kinetics of the tetrameric protein transthyretin. 2013.
    10.3233/978-1-61499-184-7-267
  2. Saraiva, M.J.; Cardoso, I.S.. Transthyretin aggregation and toxicity. 2012.
    10.1007/978-94-007-2774-8_13
  3. Saraiva, M.J.. Molecular pathogenesis associated with familial amyloidotic polyneuropathy. 2009.
    10.1007/978-3-642-00646-3_12
  4. Damas, A.M.; Saraiva, M.J.. Transthyretin. 2008.
    10.1002/9783527619344.ch21
  5. Saraiva, M.J.. Inflammation and apoptotic pathways in the peripheral nervous system related to protein misfolding. 2007.
    10.1007/978-0-387-70830-0_12
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
1991 - 2021 PhD supervisor João Pedro Moreira 2017 2021 Cristina Teixeira 2016 2020 Nádia Pereira Gonçalves 2011 2015 Ana Rita Batista 2010 2013 Marta Vieira 2009 2013 Joana Teixeira Magalhães 2008 2011 Bárbara Macedo 2003 2007 Filipe Almeida Monteiro 2003 2006 Sofia Duque Santos 2002 2005 Clara Redondo 1999 2002 Isabel Santos Cardoso 1998 2002 Mónica Mendes de Sousa 1997 2000 Maria João Bonifácio 1994 1997 Isabel Alves 1993 1997 Joana Almeida Pacheco Palha 1992 1994 Maria do Rosário Almeida 1991 1994
Orientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
1995 - 2014 Teaching at PhD, Master and Undergraduates Co-organizer and Faculty - PhD programme in Biology Molecular Neurogenetics 1995 2004 Gulbenkian Foundation Organizer and Lecturer of Master Biochemistry students - Structure and function of proteins 1995 2014 ICBAS UP Organizer and lecturer - 2nd Year Biochemistry students - Structural Biochemistry 1984 1994 - ICBAS UP PORTUGAL (1995) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
1992 - 2018 Plenary Lecture in 2018 on Therapies for FAP at the European Academy of Neurology, Lisbon Plenary Lecture in 2017 at the European Neuropathology International Symposium, in Bordeaux, France Invited Lectures at International Symposia on Amyloidoses in Japan,Uppsala , Groningen, Rome, Oslo Invited Lecture in the International Peripheral Nerve Society in 2013, S. Malô, France Invited Lectures at the Benzon Simposium, Monod conferences, EMBO symposium, FEBS conferences
Congresso
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2009 - 2018 Grants Evaluation 2017 ARN, Paris Grants Evaluation 2015 - 2018 Grant Evaluator, Brussels, each year. Joint Program in Translational Disease Scientific Advisory Board 2014 - 2017 Juri of the Neuroscience Prize from Santa Casa da Misericordia, Portugal Scientific Advisory Board 2009 2013 Member of the Scientific Council for Life Sciences, National Research Council, FCT Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1999 - 2017 Post-doctoral supervision João Carlos Gomes 2012 2017 Yohei Misumi from Kumamoto Univ, Japan 2011 2012 Dânia Teixeira 2010 2012 Nelson Ferreira (co-supervision) 2010 2015 Sandra Marisa Oliveira 2007 2013 Fátima Ferreirinha 2007 2009 Elsa Leitão (co-supervision) 2006 2009 Sofia Duque Santos 2005 2008 Isabel Cardoso 2003 2005 Hisa Terazaki (from Kumamoto Univ, Japan) 2003 2005 Mónica Sousa 2000 2002 Isabel Alves 1996 1999 Joana Almeida Palha (co-supervision) 1995 1999 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Consultoria / Parecer

Descrição da atividade Instituição / Organização
1990 - 2011 Editorial Board 2006 2011 J Biological Chemistry Editorial Board 1996 2002 - J Peripheral Nervous System Editorial Board 1993 2010 Journal - Amyloid Editorial Board 1990 1996 Neuromuscular Disorders Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2005 - 2005 - Member of Faculty in Peripheral Neuropathies- Inherited amyloidosis - International Master in Peripheral Nervous disorders - University of Milan Italy, 2019 - Organizer and Faculty in the GABBA PhD programme - Neurodegenerative Disorders 2012 2018 - Novel experimental therapies for diseases of the nervous system” –Harvard/Portugal PhD programme, Lisbon, 2010 - Faculty (MSc and PhD programmes) in Neurosciences) Neurodegeneration, Faculty of Medicine,Porto 2008-2022; Faculty of the FENS Summer School ; Faculty of the FENS Summer School- Ofir Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
1992 - 2018 10th Meeting of the Portuguese Society for Neuroscience 2007 Organizer Ofir, Portugal Peripheral Nerve: from biology to disease FENS-IBRO summer school 2003 Organizer and Faculty Ofir, Portugal 2nd, 4th , 5th , 6th, 8th-16th International Meetings on Familial Amyloid Polyneuropathy International meetings 1st and 3rd symposium on Familial Amyloidotic Polyneuropathy and transthyretin related disorders 1989 Co-organizer I
Membro
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010 - 2014 Vice-Director of IBMC, Institute for Molecular and Celular Biology , Universidade do Porto
Presidente / Vice-presidente
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007 - 2014 Director of the Bologna Master program in Biochemistry, at Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto
Diretor
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 - 2009 Coordinator of the Basic and Clinical Neurobiology Division, Institute for Molecular and Celular Biology - IBMC, Universidade do Porto
Diretor
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1994 - 1995 Chairman of the Department of Molecular Biology, Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Distinções

Prémio

2023 Giampolo Merlini Prize

Outra distinção

2019 Government Medal attributed for Merrit in Science
Ministery of Science, Portugal
2009 Gulbenkian Prize on Science
1996 Seiva Prize on Services on Science by the City of Porto