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Nélio Gonçalves is currently a Senior R&D Project Manager in the Pharmaceutical Industry taking advantage of a broad-based experience in Medical Sciences and Biotechnology from TRL-1 to TRL-9, now extended to the commercial phase. Track record of success in the field of Brain Development, where the goal was to tackle key stages of the early CNS development by molecular, immune and pharmacological tools (Cerebral Cortex 2021, 31:5652) ensuring the comprehension and therapeutic modulation of abnormal brain circuitries resulting in neurodevelopmental disorders showing multiple intellectual disabilities, and with unmet medical needs; in the field of Oncology tackling the TME by NP-based DDS (Nano Today 2021, 37:101095; IF 16.9) and NK cells' gene-editing against breast and lung cancers (Cancers 2022, 14:2217); and in the field of Neurology mostly focused on the modulation of the adenosinergic and quality control systems in multiple disorders of the CNS aiming to prevent or alleviate disease progression by either administering drugs (Ann Neurol 2013, 73:655; 2017, 81:407; IF 11.2) or through viral-mediated delivery of classical (Brain 2012, 135:2428; IF:10.9; Neuropsychopharmacol 2016, 41:2862; IF:6.4; Nat Comm 2016, 7:11915; IF:11.5; Hum Mol Genet 2018, 27:3528; IF:7.7) and emerging light-inducible (optogenetic) nucleic acids (Mol Psychiatry 2015, 20:1339; IF:15.2) in diverse genetically modified animal models of disease. Throughout this period, Nélio has had management responsibilities over 5 animal colonies. Nélio has a h-index of 16, resulting from 32+ co-authored publications mostly in high impact peer-reviewed journals (Q1 and IF>4.0) on both basic and translational science, cited over 1.196 times (Web of Science source). He has also authored/co-authored 105+ communications in national and international scientific meetings, involving 10+ collaborations and 100+ collaborators. Together, his work was distinguished by the National Ataxia Foundation, US, best lecture and Portuguese Soc of Neurosciences (best papers, 2). Was also awarded with Best National Talent under 35 years old in the Category of Science at PrémiosNovos2014, by 'Cego, Surdo e Mudo' productions. Additionally, he also actively participated in 25 national and international R&D projects funded by FCT, Santa Casa da Misericórdia (PT), DARPA, NARSAD, NAF, Alzheimer's Assoc. (USA), and by FEDER - QREN (EU), and is the recipient of up to 8 research fellowships and 1 research contract. Within this period, Nélio has lectured in postgraduate PhD (PDBEB-CNC, and Health Sciences, UC) and Master courses (FPharmacy, UC), co-supervised 11 under-graduated' and Master' students, and guided 22+ PhD and MSc research fellows and lab technicians. He has also regularly participated in the Brain Awareness and Science and Technology weeks, and in the Open Day Lab (2014-2020), thus actively promoting scientific practices and culture. Culture wise, Nélio has coordinated and instructed in 2 Music Schools and prepared 6 Music Summer Intensive Courses, managing human resources and logistics.
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Identificação

Identificação pessoal

Nome completo
Nélio da Mota Gonçalves

Nomes de citação

  • Gonçalves, Nélio
  • Gonçalves, N.
  • Gonçalves, Nelio

Identificadores de autor

Ciência ID
8211-6A03-ADFA
ORCID iD
0000-0002-0295-7143
Google Scholar ID
https://scholar.google.pt/citations?user=EW7FUIMAAAAJ&hl=en
Researcher Id
E-6146-2014
Scopus Author Id
55573902700

Endereços de correio eletrónico

  • nelio.goncalves@cnc.uc.pt (Profissional)

Telefones

Telefone
  • 239820190 (Profissional)

Moradas

  • Center for Neuroscience and Cell Biology (CNC). University of Coimbra, Rua Larga, FMUC Polo I, 1st floor, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2019/06/01 - 2021/11/07
Concluído
 Purinergic Modulation in Neurodevelopmental Disorders (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/01/01 - 2019/05/31
Concluído
 Molecular and Cellular Therapeutics based on Purinergic Modulation against the Tumor Microenvironment (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/11/30 - 2016/12/31
Concluído
 Purinergic Modulation in Neurologic Disorders (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
2013/11/29
Concluído
 Pharmaceutical Sciences (Doutoramento)
Especialização em Specialty field of Pharmaceutical Biotechnology
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Gene transfer approaches to study the role of adenosine A2A receptors in Machado-Joseph disease." (TESE/DISSERTAÇÃO)
 Unanimous Distinction and Honors
2008
Concluído
 Advanced courses at the international PhD Programme in Experimental Biology and Biomedicine (PDBEB) (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 n/a
2007/07/24
Concluído
 Pharmaceutical Sciences (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 15 (out of 20)
2006/07
Concluído
 Complementary Degree in Flute (Curso médio)
Especialização em Baroque and Classical Flute Performer
Conservatório de Música de Coimbra, Portugal
 19 (out of 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/06/01 - 2021/07/05 Investigador Contratado (Investigação) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2015/01/01 - 2019/05/31 Pós-doutorado (Investigação) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2013/11/30 - 2014/12/31 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/10/01 - 2013/11/29 Estagiário de Investigação (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/04/02 - 2007/06/28 Estagiário de Investigação (Investigação) ERASMUS Scientific Research Internship, Bélgica
Université catholique de Louvain Louvain Drug Research Institute, Bélgica
2006/12/11 - 2007/01/05 Estagiário de Investigação (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/11/08 - Atual R&D Pharmaceutical Project Manager Bluepharma, Portugal
Bluepharma, Portugal
2015/01/01 - 2017/04/01 Director Associação Filarmónica Artística Pombalense, Portugal
Associação Filarmónica Artística Pombalense, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/01/15 - 2007/03/15 Extra-curricular Academic Internship Coimbra Hospital and University Centre - Pediatric Hospital - Pharmaceutical Services, Portugal
2006/09/04 - 2006/12/09 Extra-curricular Academic Internship Community pharmacy: Farmácia Luciano & Matos, Portugal
2005/11/23 - 2006/04/13 Extra-curricular Academic Internship Universidade de Coimbra Faculdade de Farmácia Laboratório de Análises Clínicas, Portugal
Projetos

Bolsa

Designação Financiadores
2014 - 2016 Role of adenosine A2A receptors in the accumbens and amygdala in the control of chronic stress neuropathology.
-
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Brain and Behavior Research Foundation
Concluído
2013 - 2016 Caffeine alleviation of MJD/SCA3
2013 41(1)
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 National Ataxia Foundation (NAF)
Concluído
2014/09 - 2015 The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer’s disease.
MB-98-2014
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Santa Casa da Misericórdia de Lisboa
Concluído
2011/04/01 - 2014/08/30 Cell to cell transport of alpha-synuclein in Parkinson´s Disease. The progression factor?
PTDC/SAU-NMC/109955/2009
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2018/07 - Atual A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis.
PTDC/MED-NEU/28160/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/01/01 - 2019/05/31 CANCEL-STEM: Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
POCI-01-0145-FEDER-016390
SAICTPAC/0022/2015
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/01 - 2019/05 Towards a single therapy against triple negative breast cancer and neuroblastoma by nucleolin-mediated multicellular targeting with a synergistic drug combination.
ENMed/0005/2015
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/05 - 2019/04 Role of astrocytes in the control of memory-focus on adenosine A2A receptors
Provided by PTCRIS: 142785
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/05 - 2018/10 Hybrid ionotropic receptors: a new concept of receptor
Provided by PTCRIS: 142196
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2015/11 - 2018/10 P2Y1 receptor-CRMP2 control synaptic loss and memory impairment in early Alzheimer’s Disease
NIRG-15-361884
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Alzheimer's Association
Concluído
2013/12 - 2015 New Treatments for Stress-induced Dysregulation of Circuits Regulating Reward, Fear, and Habit Learning
09-68-ESR-FP-010
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Defense Advanced Research Projects Agency
Concluído
2012/04 - 2014/09 Role of accumbens and amygdala in the control of chronic stress neuropathology
Provided by PTCRIS: 122254
122254
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/10 - 2013/11 New Treatments for Stress-induced Dysregulation of Circuits Regulating Reward, Fear, and Habit Learning
DARPA-09-68-ESR-FP-010
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Defense Advanced Research Projects Agency
Concluído
2010/02 - 2013/04 The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors
99307
Provided by PTCRIS: 99307
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2013 Aging, Stress and Chronic Diseases: From Mechanisms to Therapeutics
CENTRO-07-ST24-FEDER-002006
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Instituto de Investigação Interdisciplinar
Concluído
2010/03 - 2012/02 Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage
108668
Provided by PTCRIS: 108668
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/04/02 - 2007/06/28 Tumoral microenvironment study after the electroporation of a plasmid coding for an antiangiogenic factor.
LSHB-CT-2005-512127
Outra
Université catholique de Louvain Louvain Drug Research Institute, Bélgica
 European Commission Sixth Framework Programme
Concluído
Produções

Publicações

Artigo em revista
  1. Liliana Dias; Daniela Pochmann; Cristina Lemos; Henrique B. Silva; Joana I. Real; Francisco Q. Gonçalves; Daniel Rial; et al. "Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress". ACS Chemical Neuroscience (2023): http://dx.doi.org/10.1021/acschemneuro.2c00810.
    10.1021/acschemneuro.2c00810
  2. Francisco Q. Gonçalves; Filipe C. Matheus; Henrique B. Silva; Joana I. Real; Daniel Rial; Ricardo J. Rodrigues; Jean-Pierre Oses; et al. "Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease". Molecular Neurobiology (2023): http://dx.doi.org/10.1007/s12035-022-03162-1.
    10.1007/s12035-022-03162-1
  3. Xinli Xu; Rui O. Beleza; Francisco Q. Gonçalves; Sergio Valbuena; Sofia Alçada-Morais; Nélio Gonçalves; Joana Magalhães; et al. "Adenosine A2A receptors control synaptic remodeling in the adult brain". Scientific Reports (2022): http://dx.doi.org/10.1038/s41598-022-18884-4.
    10.1038/s41598-022-18884-4
  4. Ângela Valério-Fernandes; Nuno A. Fonseca; Nélio Gonçalves; Ana F. Cruz; Marta I. Pereira; Ana C. Gregório; Vera Moura; et al. "Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer". Cancers (2022): https://doi.org/10.3390/cancers14092217.
    10.3390/cancers14092217
  5. Elisabete Augusto; Francisco Q. Gonçalves; Joana E. Real; Henrique B. Silva; Daniela Pochmann; Tiago S. Silva; Marco Matos; et al. "Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction". Neurobiology of Disease (2021): http://dx.doi.org/10.1016/j.nbd.2021.105441.
    10.1016/j.nbd.2021.105441
  6. Ana F. Cruz; Mariana B. Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al. "The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway". Cancers 13 12 (2021): 3052-3052. https://doi.org/10.3390/cancers13123052.
    10.3390/cancers13123052
  7. Nuno A. Fonseca; Ana C. Gregório; Vera M. Mendes; Rui Lopes; Teresa Abreu; Nélio Gonçalves; Bruno Manadas; et al. "GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure". Nano Today (2021): https://doi.org/10.1016/j.nantod.2021.101095.
    10.1016/j.nantod.2021.101095
  8. Laura Sofia Carvalho; Nélio Gonçalves; Nuno André Fonseca; João Nuno Moreira. "Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis". Pharmaceuticals 14 1 (2021): 60-60. https://doi.org/10.3390/ph14010060.
    10.3390/ph14010060
  9. Abreu, Teresa; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno. "Current challenges and emerging opportunities of CAR-T cell therapies". Journal of Controlled Release 319 (2020): 246-261. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077491524&partnerID=MN8TOARS.
    Publicado • 10.1016/j.jconrel.2019.12.047
  10. Gonçalves, Francisco Queiroz (9913-5AC8-052C); Lopes, João; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al. "Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine". Neurobiology of Disease 132 (2019): 104570. http://dx.doi.org/10.1016/j.nbd.2019.104570.
    Publicado • 10.1016/j.nbd.2019.104570
  11. Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Lisiane O. Porciúncula; Simões, Ana; Augusto, Elisabete; Henrique B. Silva; Machado, Nuno J.; Gonçalves, Nélio; et al. "Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions". eneuro (2018): ENEURO.0385-18.2018. https://doi.org/10.1523/ENEURO.0385-18.2018.
    Publicado • 10.1523/ENEURO.0385-18.2018
  12. Leffa, D.T.; Pandolfo, P.; Gonçalves, Nélio; Machado, Nuno J.; de Souza, Caroline M.; Real, Joana; Silva, António Carvalho; et al. "Adenosine A2A receptors in the rat prelimbic medial prefrontal cortex control delay-based cost-benefit decision making". Frontiers in Molecular Neuroscience 11 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85059003991&partnerID=MN8TOARS.
    Publicado • 10.3389/fnmol.2018.00475
  13. Morató, Xavier; Luján, R.; Gonçalves, Nélio; Watanabe, M.; Altafaj, X.; Carvalho, Ana Luisa; Fernández-Dueñas, V.; Cunha, Rodrigo A.; Ciruela, Francisco. "Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation". Human molecular genetics 27 20 (2018): 3528-3541. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS.
    Publicado • 10.1093/hmg/ddy264
  14. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Prediger, Rui D.; Hirai, H.; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia". Annals of Neurology 81 3 (2017): 407-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013441188&partnerID=MN8TOARS.
    Publicado • 10.1002/ana.24867
  15. Viana da Silva, Silvia; Haberl, Matthias Georg; Zhang, Pei; Bethge, Philipp; Lemos, Cristina; Gonçalves, Nélio; Gorlewicz, Adam; et al. "Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors". Nature Communications 7 1 (2016): http://dx.doi.org/10.1038/ncomms11915.
    Publicado • 10.1038/ncomms11915
  16. Rial, Daniel; Lemos, C.; Pinheiro, H.; Duarte, J.M.; Gonçalves, Francisco Queiroz (9913-5AC8-052C); Real, Joana; Prediger, R.D.; et al. "Depression as a glial-based synaptic dysfunction". Frontiers in Cellular Neuroscience 9 JAN2016 (2016): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957876863&partnerID=MN8TOARS.
    Publicado • 10.3389/fncel.2015.00521
  17. Simões, Ana; Gonçalves, Nélio; Kaster, Manuella; Simões, Ana Teresa Antunes (E715-7062-B946); Nunes, A.; Pereira de Almeida, Luis Fernando Morgado; Goosens, K.A.; Rial, Daniel; Cunha, Rodrigo A.. "Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory". Neuropsychopharmacology 41 12 (2016): 2862-2871. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978777019&partnerID=MN8TOARS.
    Publicado • 10.1038/npp.2016.98
  18. Li, P.; Rial, Daniel; Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al. "Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory". Molecular Psychiatry 20 11 (2015): 1339-1349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946498281&partnerID=MN8TOARS.
    Publicado • 10.1038/mp.2014.182
  19. Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa Antunes (E715-7062-B946); den Dunnen, W.F.A.; Hirai, H.; Kügler, Sebastian; Cavadas, Claudia; Pereira de Almeida, Luis Fernando Morgado. "Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease". Human Molecular Genetics 24 19 (2015): 5451-5463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943793236&partnerID=MN8TOARS.
    Publicado • 10.1093/hmg/ddv271
  20. Li, P.; Rial, Daniel; Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al. "Erratum: Optogenetic activation of intracellular adenosine A2A Receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory (Molecular Psychiatry (2015) 20, 1339-1349 DOI:10.1038/mp.2014.182)". Molecular Psychiatry 20 11 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946495951&partnerID=MN8TOARS.
    Publicado • 10.1038/mp.2015.43
  21. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of machado-Joseph disease". Human Molecular Genetics 23 18 (2014): 4932-4944. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906821927&partnerID=MN8TOARS.
    Publicado • 10.1093/hmg/ddu209
  22. Gomes, Catarina; Ferreira, Raquel; George, Jimmy; Sanches, Rui; Rodrigues, Diana I; Gonçalves, Nélio; Cunha, Rodrigo A.. "Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia". Journal of Neuroinflammation 10 1 (2013): http://dx.doi.org/10.1186/1742-2094-10-16.
    Publicado • 10.1186/1742-2094-10-16
  23. Crokart, Nathalie; Danhier, Fabienne; Daugimont, Liévin; Gonçalves, Nélio; Jordan, B.F.; Grégoire, V.; Feron, Olivier; et al. "Potentiation of radiotherapy by a localized antiangiogenic gene therapy". Radiotherapy and Oncology 107 2 (2013): 252-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879019526&partnerID=MN8TOARS.
    Publicado • 10.1016/j.radonc.2013.03.018
  24. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease". Annals of Neurology 73 5 (2013): 655-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878306815&partnerID=MN8TOARS.
    Publicado • 10.1002/ana.23866
  25. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Koeppen, Arnulf; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease". Brain 135 8 (2012): 2428-2439. http://dx.doi.org/10.1093/brain/aws177.
    Publicado • 10.1093/brain/aws177
Artigo em revista (magazine)
  1. Gonçalves, Nélio. "Investigação em Neurociências, perto de nós", Pombal Jornal, 2015
  2. Gonçalves, Nélio. "Ciência, uma constante da vida", CX a revista da Caixa, 2014
  3. Gonçalves, Nélio. "Qual a ligação da doença de Machado-Joseph a Portugal", Jornal I, 2014
Capítulo de livro
  1. Abreu, Teresa Raquel Tremoço Dias; Biscaia, Mariana; Gonçalves, Nélio; Fonseca, Nuno A.; Moreira, João Nuno. "In Vitro and In Vivo Tumor Models for the Evaluation of Anticancer Nanoparticles". In Advances in Experimental Medicine and Biology, editado por Santos, Hélder A.; Fontana, F., 271-299. Springer International Publishing, 2021.
    Publicado • 10.1007/978-3-030-58174-9_12
Poster em conferência
  1. Gonçalves, Nélio; Laura Sofia dos Santos Carvalho. "Nucleolin downregulation in triple negative breast cancer cells: a key protein for phenotypic aggressiveness?". Trabalho apresentado em BEBDAY 2019, 2019.
  2. Biscaia-Caleiras, Mariana; Fonseca, Nuno A.; Cruz, Ana; Gonçalves, Nélio; Moreira, João Nuno. "Targeted delivery of doxorubicin and C6-ceramide combinations to non-small cell lung cancer cells - Key factors for C6-ceramide's cytotoxocity.". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  3. Rial, Daniel; Gonçalves, Nélio. "Role of astrocytic adenosine A2A receptors in the facilitation of synaptic plasticity in cortico-striatal synapses.". Trabalho apresentado em 1st European Purine Meeting by the Spanish Purine Club, 2019.
  4. Cruz, Ana; Gonçalves, Nélio. "Differential effect of liposomal C6-ceramide/doxorubicin targeted to nucleolin and conventional combinations against triple negative breast cancer stem cells.". Trabalho apresentado em Annual Meeting of the American Association for Cancer Research 2019., 2019.
  5. Gonçalves, Nélio; Fonseca, Nuno A.; Moreira, João Nuno. "Cell surface/cytoplasmic relative levels of nucleolin: a key feature for successful anticancer nanotherapies targeting nucleolin.". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  6. Gonçalves, Nélio; Henriques, Vanessa Jorge. "Astrocytic A2A receptors: novel targets to manage brain disorders.". Trabalho apresentado em 12th Young European Scientist Meeting, 2017.
  7. Rodrigues, Ricardo J.; Gonçalves, Nélio. "Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation.". Trabalho apresentado em ISN-ESN Meeting, 2017.
  8. Alçada-Morais, Sofia; Gonçalves, Nélio. "Cortical neuronal migration entails A2A receptor-driven neuronal polarization and axon formation.". Trabalho apresentado em XV Annual Meeting of the Portuguese Society for Neuroscience, 2017.
  9. Lopes, João; Gonçalves, Nélio. "The blockade of neuronal A2A adenosine receptors prevents impairment by ß-amyloid peptides of hippocampal synaptic plasticity.". Trabalho apresentado em XV Annual Meeting of the Portuguese Society for Neuroscience, 2017.
  10. Alçada-Morais, Sofia; Gonçalves, Nélio. "Adenosine A2A receptor controls cortical neuronal migration.". Trabalho apresentado em Brain With]Out[ Borders, 2016.
  11. Canas, Paula M.; Gonçalves, Nélio. "Adenosine A2A receptors up-regulation in glutamate synapses is critical for synaptotoxicity pre-dating the development of convulsions-induced neurodegeneration.". Trabalho apresentado em 10th FENS Forum of Neuroscience, 2016.
  12. Gonçalves, Nélio; Alçada-Morais, Sofia. "Adenosine A2A receptors control cortical neuronal migration.". Trabalho apresentado em 10th FENS Forum of Neuroscience, 2016.
  13. Gonçalves, Nélio; Cunha, Rodrigo A.. "Selective amygdala neuronal down-regulation of adenosine A2A receptors prevents mood-related modifications.". Trabalho apresentado em 7th International Society for Neurochemistry Meeting, 2016.
  14. Simões, Ana Patricia; Gonçalves, Nélio. "Adenosine A2A receptors in the amygdala control synaptic plasticity and fear memory.". Trabalho apresentado em 7th International Society for Neurochemistry Meeting, 2016.
  15. Lopes, João; Gonçalves, Nélio. "ATP-derived adenosine controls Aß-induced impairment of behaviour and synaptic plasticity.". Trabalho apresentado em 7th International Society for Neurochemistry Meeting, 2016.
  16. Alçada-Morais, Sofia; Gonçalves, Nélio. "Adenosine A2A receptors control axon formation during neuronal development: implications to neuronal migration and epileptogenesis.". Trabalho apresentado em 7th International Society for Neurochemistry Meeting, 2016.
  17. Machado, Nuno J.; Gonçalves, Nélio. "The ablation of neuronal A2AR selectively in the amygdala prevents mood changes triggered by chronic stress.". Trabalho apresentado em VI Brazilian Purine Club Meeting, 2016.
  18. Simões, Ana Patricia; Gonçalves, Nélio. "Amygdalar adenosine A2A receptors control synaptic plasticity and fear memory.". Trabalho apresentado em XIV Annual Meeting of the Portuguese Society for Neuroscience, 2015.
  19. Kerkhofs, A; Gonçalves, Nélio. "Adenosine A2A receptors selectively control long-term potentiation in rodent prelimbic medial prefrontal cortex and human cortical areas.". Trabalho apresentado em . XIV Annual Meeting of the Portuguese Society for Neuroscience, 2015.
  20. Alçada-Morais, Sofia; Gonçalves, Nélio. "Adenosine A2A receptors control cortical neurons migration.". Trabalho apresentado em XIV Annual Meeting of the Portuguese Society for Neuroscience, 2015.
  21. Rial, Daniel; Gonçalves, Nélio. "The adenosine facilitation of synaptic plasticity in cortico-striatal synapses is co-operated by the presynaptic and astrocytic A2A receptors.". Trabalho apresentado em V Meeting of the Brazilian Purine Club, 2015.
  22. Gonçalves, Nélio; Pereira de Almeida, Luís. "Caffeine alleviates progressive motor deficits in Machado-Joseph disease transgenic mice.". Trabalho apresentado em IARC 2015 – International Ataxia Research Conference, 2015.
  23. Gonçalves, Nélio; Cunha, Rodrigo A.. "Adenosine A2A receptors in the amygdala neurons control mood modifications in rats subjected to repeated restraint stress.". Trabalho apresentado em XII Annual Meeting of the Center for Neuroscience and Cell Biology, 2014.
  24. Simões, Ana Patricia; Gonçalves, Nélio. "Adenosine A2A receptors in the amygdala control synaptic plasticity and conditional fear memory.". Trabalho apresentado em XII Annual Meeting of the Center for Neuroscience and Cell Biology., 2014.
  25. Duarte-Neves, Joana; Gonçalves, Nélio. "Therapeutic role of neuropeptide Y in mouse models of Machado-Joseph Disease.". Trabalho apresentado em XII Annual Meeting of the Center for Neuroscience and Cell Biology, 2014.
  26. Gonçalves, Nélio; Cunha, Rodrigo A.. "The genetic deletion of adenosine A2A receptors selectively from amygdala neurons prevents mood-related modifications in rats subjected to repeated restraint stress.". Trabalho apresentado em Neuroscience 2014, 44th Annual Meeting of the Society for Neuroscience., 2014.
  27. Ferreira, Samira G.; Gonçalves, Nélio. "Adenosine A2A receptors control impulsivity and synaptic plasticity in the prelimbic medial prefrontal cortex – interaction with dopamine D2-like receptors.". Trabalho apresentado em Neuroscience 2014, 44th Annual Meeting of the Society for Neuroscience, 2014.
  28. Simões, Ana Patricia; Gonçalves, Nélio. "Adenosine A2A receptors in the amygdala control synaptic plasticity and conditional fear memory.". Trabalho apresentado em Neuroscience 2014, 44th Annual Meeting of the Society for Neuroscience, 2014.
  29. Gonçalves, Nélio; Cunha, Rodrigo A.. "Synaptic and glia involvement in the purinergic control of neurodegenerative diseases.". Trabalho apresentado em Purines International Conference on Nucleotides, Nucleosides and Nucleobases, 2014.
  30. Gonçalves, Nélio; Simões, Ana Patricia. "Adenosine A2A receptors control fear responses and synaptic plasticity in the amygdala.". Trabalho apresentado em 9th FENS Forum of Neuroscience, 2014.
  31. Machado, Nuno J.; Gonçalves, Nélio. "Amygdalar adenosine A2A receptors control mood-related modifications in rats subjected to repeated restraint stress.". Trabalho apresentado em 9th FENS Forum of Neuroscience, 2014.
  32. Simões, Ana Teresa; Gonçalves, Nélio. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em AIM 2014 – 5th Ataxia Investigators Meeting of the National Ataxia Foundation, 2014.
  33. Gonçalves, Nélio. "Role of adenosine A2A receptors in the ventromedial striatum and in the amygdala to control behavioral modifications in rats subjected to repeated restraint stress.". Trabalho apresentado em Neuroscience 2013, 43th Annual Meeting of the Society for Neuroscience., 2013.
  34. Rial, Daniel; Gonçalves, Nélio. "The adenosine A2AR facilitation of synaptic plasticity in cortico-striatal synapses depends on ATP-derived adenosine and involves cooperation between presynaptic and astrocytic A2AR.". Trabalho apresentado em Neuroscience 2013, 43th Annual Meeting of the Society for Neuroscience., 2013.
  35. Gonçalves, Nélio; Simões, Ana Teresa. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em CAG Triplet repeat disorders, Gordon research conferences, 2013.
  36. Gonçalves, Nélio; Cunha, Rodrigo A.. "Impact of ventro-medial striatal adenosine A2A receptors on mood- and anxiety-related behavioral modifications in rats subjected to repeated restraint stress.". Trabalho apresentado em XIII Annual Meeting of the Portuguese Society for Neuroscience, 2013.
  37. Simões, Ana Teresa; Gonçalves, Nélio. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em XIII Annual Meeting of the Portuguese Society for Neuroscience, 2013.
  38. Machado, Nuno J.; Gonçalves, Nélio. "Adenosine A2A receptors in the amygdala control behavioral modifications in rats subjected to repeated restraint stress.". Trabalho apresentado em XIII Annual Meeting of the Portuguese Society for Neuroscience, 2013.
  39. Simões, Ana Patricia; Gonçalves, Nélio. "Role of adenosine A2A receptors in the amygdala : implications for mood disorders.". Trabalho apresentado em XIII Annual Meeting of the Portuguese Society for Neuroscience, 2013.
  40. Leffa, Douglas T; Gonçalves, Nélio. "Adenosine A2A receptors in the prefrontal cortex controls impulsive behavior in rats.". Trabalho apresentado em XIII Annual Meeting of the Portuguese Society for Neuroscience, 2013.
  41. Real, Joana I; Gonçalves, Nélio. "Adenosine A2A receptors control the modification caused by repeated restraint stress of synaptic plasticity in the pre-frontal cortex from rat brain slices.". Trabalho apresentado em XIII Annual Meeting of the Portuguese Society for Neuroscience, 2013.
  42. Gonçalves, Nélio; Cunha, Rodrigo A.. "Chronic caffeine consumption delays neurodegeneration and improves motor balance and coordination in mouse models of Machado-Joseph disease.". Trabalho apresentado em 8th FENS Forum of Neuroscience, 2012.
  43. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpain-mediated proteolysis promotes mutant ataxin-3 translocation to the nucleus and neurodegeneration.". Trabalho apresentado em The Biology of Calpains in Health and Disease, 2010.
  44. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Antagonism of adenosine A2A receptors delays neurodegeneration in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em Science 2010 – Meeting with Science and Technology, 2010.
  45. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpain-mediated proteolysis promotes mutant ataxin-3 translocation to the nucleus and neurodegeneration.". Trabalho apresentado em Science 2010 – Meeting with Science and Technology, 2010.
  46. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Antagonism of adenosine A2A receptors delays neurodegeneration in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em Purines 2010, Adenine Nucleosides and Nucleotides in Biomedicine, 2010.
  47. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Antagonism of adenosine A2A receptors provides neuroprotection in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em Neuroscience 2009, 39th Annual Meeting of the Society for Neuroscience., 2009.
  48. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Calpains promote mutant ataxin-3 translocation to the nucleus and neurodegeneration.". Trabalho apresentado em Neuroscience 2009, 39th Annual Meeting of the Society for Neuroscience, 2009.
  49. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Blockade of adenosine receptors by caffeine provides neuroprotection in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em XI Annual Meeting of the Portuguese Society for Neuroscience, 2009.
  50. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Pereira de Almeida, Luis Fernando Morgado. "Inhibition of mutant ataxin-3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em XI Annual Meeting of the Portuguese Society for Neuroscience, 2009.
  51. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Adenosine A2A receptors antagonism delays neurodegeneration in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009.
  52. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of capains prevents translocation of mutant ataxin-3 to the nucleus and reduces neurodegeneration in a lentiviral mouse model of Machado-Joseph Disease". Trabalho apresentado em IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009.
Resumo em conferência
  1. Gonçalves, Nélio; Machado, Nuno J.; Simões, AP; Cunha, Rodrigo A.. "Selective Down-Regulation of Neuronal A2A Receptors in the Basolateral Amygdala Prevents Behavioural Modifications Induced by Repeated Stress". 2020.
    Publicado • 10.1016/j.biopsych.2020.02.571
  2. Cruz, Ana; Fonseca, Nuno A.; Gonçalves, Nélio; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Differential effect of liposomal C6-ceramide/doxorubicin targeted to nucleolin and conventional combinations against triple negative breast cancer stem cells.". Trabalho apresentado em American Association for Cancer Research (AACR) 2019, Atlanta, 2019.
    Publicado
  3. Henriques, Vanessa Jorge; Gonçalves, Nélio; Agostinho, Paula; Cunha, Rodrigo A.. "Astrocytic A2A receptors: Novel targets to manage brain disorders". Trabalho apresentado em 12th Young European Scientist Meeting, Porto, 2017.
    Publicado • 10.1016/j.pbj.2017.07.011
  4. Rodrigues, Ricardo J.; Alçada-Morais, Sofia; Moreno-Juan, V; Gonçalves, Nélio; Andres, B.; Ferreira, Samira G.; Marques, Joana; et al. "Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation". Trabalho apresentado em SN-ESN MEETING 2017, Paris, 2017.
    Publicado
  5. Rial, Daniel; Gonçalves, Nélio; Gonçalves, Francisco Queiroz (9913-5AC8-052C); Real, Joana; Silva, Henrique B.; Prediger, Rui D.; Chen, Jiang-Fan; et al. "The Adenosine Facilitation of Synaptic Plasticity in Cortico-Striatal Synapses is Co-operated by the Presynaptic and Astrocytic A2A Receptors.". Trabalho apresentado em Brazilian Purine Club Meeting, São Sebastião, 2016.
    Publicado • 10.1007/s11302-016-9503-x
  6. Duarte-Neves, Joana; Cunha-Santos, Janete; Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); den Dunnen, Wilfred F.A.; Hirai, Hirokazu; Kügler, Sebastian; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y alleviates Machado–Joseph disease". Trabalho apresentado em Advances in NPY Research, 2016.
    Publicado • 10.1016/j.npep.2015.11.013
  7. Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Rial, Daniel; Simões, Ana; Lopes, João; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, Francisco Queiroz (9913-5AC8-052C); et al. "Synaptic and glia involvement in the purinergic control of neurodegenerative diseases.". Trabalho apresentado em International Conference on Nucleotides, Nucleosides and Nucleobases, Bonn, 2014.
    Publicado • 10.1007/s11302-014-9430-7
  8. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Antagonism of Adenosine A2A Receptors Delays Neurodegeneration in a Lentiviral Mouse Model of Machado-Joseph Disease". Trabalho apresentado em Purines 2010: Adenine Nucleosides and Nucleotides in Biomedicine, Tarragona, 2010.
    Publicado • 10.1007/s11302-010-9187-6
  9. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Nóbrega, Clévio; Déglon, Nicole; Duarte, Carlos B.; Kügler, Sebastian; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of Mutant Ataxin-3 Proteolysis by Calpains in a Lentiviral Mouse Model of Machado-Joseph Disease". Trabalho apresentado em V International Workshop on MJD, São Miguel, Azores, 2009.
    Publicado • 10.3389/conf.neuro.01.2009.11.100
  10. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Blockade of adenosine receptors by caffeine provides neuroprotection in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience, Braga, 2009.
    Publicado • 10.3389/conf.neuro.01.2009.11.105
Tese / Dissertação
  1. Gonçalves, Nélio da Mota. "Gene transfer approaches to study the role of adenosine A2A receptors in Machado-Joseph disease". Doutoramento, Universidade de Coimbra Faculdade de Farmácia, 2013. http://hdl.handle.net/10316/23679.

Outros

Norma técnica
  1. Certification for Medical Waste Integrated Management. Certified researcher for Medical Waste Integrated Management, by Stericycle Portugal, Portugal. 2015. Gonçalves, Nélio.
  2. Certification for Stereological Applications in Experimental Pathology and Regenerative Medicine.. Certified researcher for Stereological Analysis by the Faculty of Medicine, University of Coimbra & Portuguese Association for Experimental Pathology, Portugal. 2008. Gonçalves, Nélio.
Técnica de investigação
  1. FELASA Category B certified researcher for Carrying out Animal Experiments, by Direção Geral de Alimentação e Veterinária (DGAV), Ministério da Agricultura e do Mar, Portugal (2014). Investigador. Gonçalves, Nélio.
    Investigador
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/11/15 Synergistic cytotoxicity of targeted liposomal C6-ceramide and doxorubicin against nucleolin-overexpressing cancer cells is supported by the downregulation of the PI3K/Akt pathway. 1st Annual Meeting in Pharmaceutical Sciences
University of Coimbra, Faculty of Pharmacy (Coimbra, Portugal)
2019/11/15 Nucleolin downregulation in triple negative breast cancer cells: exploring the phenotypic implications of a therapeutic target. 1st Annual Meeting in Pharmaceutical Sciences
University of Coimbra Faculty of Pharmacy (Coimbra, Portugal)
2019/09/04 Cortical neuronal migration entails A2A receptor-driven neuronal polarization and axon formation. 1st European Purine Meeting
Spanish Purine Club (Santiago de Compostela, Espanha)
2019/09/04 ATP-derived adenosine controls synaptic and memory dysfunction in ß-amyloid models of Alzheimer’s disease. 1st European Purine Meeting
Spanish Purine Club (Santiago de Compostela, Espanha)
2019/07/20 The potential of liposomal C6-ceramide/doxorubicin targeted to nucleolin to decrease triple-negative breast cancer stem cell population relative to a standard of treatment. 2019 Annual Meeting
Controlled Release Society (Valencia, Espanha)
2019/05/10 Adenosine A2A receptor contributes to hipocampal mossy fiber sprouting during epileptogenesis. I CIBB Neuroscience and Disease Retreat
Center for Neuroscience and Cell Biology (Miranda do Corvo, Portugal)
2019/02/06 Adenosine A2A receptors in the rat prelimbic medial prefrontal cortex control delay-based cost-benefit decision making. XLIX Annual Meeting
Portuguese Pharmacological Society (Porto, Portugal)
2017/10/13 Adenosine A2A receptors induce the formation of abnormal secondary axons in rat hippocampal neurons: a new target to arrest epileptogenesis. 12th Biennial Conference
Chinese Neuroscience Society (Tianjin, China)
2017/09/14 Astrocytic A2A receptors: novel targets to manage brain disorders. 12th Young European Scientist Meeting
(Porto, Portugal)
2017/08/20 Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation. ISN-ESN Biennial Meeting
ISN-ESN (Paris, França)
2017/05/25 Cortical neuronal migration entails A2A receptor-driven neuronal polarization and axon formation. XV Annual Meeting
Portuguese Society for Neuroscience (Braga, Portugal)
2017/05/25 Activation of neuronal A2AR by ATP-derived adenosine facilitates hippocampal LTP: physiopathological role of CD73. XV Annual Meeting
Portuguese Society for Neuroscience (Braga, Portugal)
2017/02/02 Selective down-regulation of amygdala neuronal A2A receptors prevents behavioural modifications induced by stress. XLVII Annual Meeting
Portuguese Pharmacological Society (Coimbra, Portugal)
2017/02/02 The blockade of neuronal A2A adenosine receptors prevents impairment by ß-amyloid of hippocampal synaptic plasticity. XLVII Annual Meeting
Portuguese Pharmacological Society (Coimbra, Portugal)
2017/02/02 ATP-derived adenosine is responsible for the activation of neuronal A2A receptors to facilitate long-term potentiation in the mouse hippocampus. XLVII Annual Meeting
Portuguese Pharmacological Society (Coimbra, Portugal)
2017/01/30 Adenosine A2A receptors control cortical neurons migration. BEB Day: not so usual insights into a PhD
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016/11/18 Adenosine A2A receptor controls cortical neuronal migration. Brain With]Out[ Borders
University of Coimbra Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016/05/12 The ablation of neuronal A2AR selectively in the amygdala prevents mood changes triggered by chronic stress. VI Brazilian Purine Club Meeting
Purine Club Meeting (Paraíba, Brasil)
2016/05/12 Purinergic control of neurodegeneration triggered by convulsions. VI Brazilian Purine Club Meeting
Purine Club Meeting (Paraíba, Brasil)
2016/02/04 Selective amygdala neuronal down-regulation of A2A receptors prevents behavioural modifications induced by stress XLVI Annual Meeting
Portuguese Pharmacological Society (Porto, Portugal)
2016 Adenosine A2A receptors control cortical neurons migration. XLVI Meeting of the Portuguese Society of Pharmacology, XXXIV Clinic Pharmacology & XV Toxicology
Portuguese Society of Pharmacology (Porto, Portugal)
2015/12/17 Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease XIII Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2015/12/17 Adenosine A2A receptors control cortical neurons migration. XIII Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2015/06/04 The triad of behavioural modifications characteristic of depression is abrogated by the selective amygdala neuronal down-regulation of adenosine A2A receptors. XIV Annual Meeting
Portuguese Society for Neuroscience (Póvoa de Varzim, Portugal)
2015/03/25 Therapeutic role of neuropeptide Y in mouse models of Machado-Joseph Disease. International Ataxia Research Conference
Ataxia UK (Windsor, Reino Unido)
2015/02/05 Adenosine A2A receptors selectively modulate long-term plasticity in the amygdala of mice and control fear memory. XLV Annual Meeting
Portuguese Pharmacological Society (Lisbon, Portugal)
2015/02/05 Neuropeptide Y alleviates neuropathological and behavioral abnormalities in mice models of Machado-Joseph Disease. XLV Annual Meeting
Portuguese Pharmacological Society (Lisbon, Portugal)
2014/12/15 Medial prefrontal cortex adenosine A2A receptors control impulsive behavior and long-term potentiation – interaction with dopamine D2-like receptors. XII Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2014/11/06 Depression: searching for new therapeutic targets. VIII Scientific Congress: Brain and (dys)functions
Universidade de Coimbra, Núcleo de Estudante da Faculdade de Farmácia (Coimbra, Portugal)
2014/11/06 Depression: searching for new therapeutic targets Brain and (Dys)Functions | Cérebro e (Dis)Funções
Universidade de Coimbra Faculdade de Farmácia (Coimbra, Portugal)
2014/03 Caffeine alleviates progressive motor deficits in MJD transgenic mice. AIM 2014 – 5th Ataxia Investigators Meeting
National Ataxia Foundation (Las Vegas, Nevada, Estados Unidos)
2014/02/05 Adenosine A2A receptors in the amygdala control behavioural modifications in rats subjected to repeated restraint stress. XLIV Annual Meeting
Portuguese Pharmacological Society (Coimbra, Portugal)
2014/02/05 Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease. XLIV Annual Meeting
Portuguese Pharmacological Society. (Coimbra, Portugal)
2014/02/05 Neuropeptide Y neuroprotective role in a lentiviral model of Machado-Joseph Disease. XLIV Annual Meeting
Portuguese Pharmacological Society. (Coimbra, Portugal)
2014/02/05 Role of adenosine A2A receptors in the amygdala: Implications for mood disorders. XLIV Annual Meeting
Portuguese Pharmacological Society (Coimbra, Portugal)
2013/11/09 Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease. Neuroscience 2013, 43th Annual Meeting
Society for Neuroscience (San Diego, California, Estados Unidos)
2013/05/30 Impact of ventro-medial striatal adenosine A2A receptors on mood- and anxiety-related behavioral modifications in rats subjected to repeated restraint stress. XIII Annual Meeting
Portuguese Society for Neuroscience (Luso, Portugal)
2013/05/30 Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease. XIII Annual Meeting
Portuguese Society for Neuroscience (Luso, Portugal)
2013/05/30 Adenosine A2A receptors in the amygdala control behavioral modifications in rats subjected to repeated restraint stress. XIII Annual Meeting
Portuguese Society for Neuroscience (Luso, Portugal)
2013/05/30 Role of adenosine A2A receptors in the amygdala : implications for mood disorders. XIII Annual Meeting
Portuguese Society for Neuroscience (Luso, Portugal)
2013/05/30 Adenosine A2A receptors in the prefrontal cortex controls impulsive behavior in rats. XIII Annual Meeting
Portuguese Society for Neuroscience (Luso, Portugal)
2013/05/30 Adenosine A2A receptors control the modification caused by repeated restraint stress of synaptic plasticity in the pre-frontal cortex from rat brain slices. Annual Meeting
Portuguese Society for Neuroscience (Luso, Portugal)
2012/02/02 Pharmacological antagonism or genetic deletion of adenosine A2A receptors delay neurodegeneration in a lentiviral mouse model of Machado-Joseph disease. XLI Annual Meeting
Portuguese Pharmacological Society (Coimbra, Portugal)
2011/02/02 Calpains cleave mutant ataxin-3 promoting Machado-Joseph Disease. XLI Annual Meeting
Portuguese Pharmacological Society. (Coimbra, Portugal)
2010/12/20 Pharmacological antagonism or genetic deletion of adenosine A2A receptors delay neurodegeneration in a lentiviral mouse model of Machado-Joseph disease. VIII Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2010/12/20 Calpain-mediated proteolysis promotes mutant ataxin-3 translocation to the nucleus and neurodegeneration. VIII Annual Meeting
Center for Neuroscience and Cell Biology. (Coimbra, Portugal)
2009/04/01 Gene transfer approach for the study of the adenosine A2A receptors role in Machado-Joseph disease. V International Workshop on MJD.
(S. Miguel, Azores, Portugal)
2009/04/01 Inhibition of calpains in a lentiviral mouse model of MJD prevents nuclear localization and reduces neuronal dysfunction and degeneration. V International Workshop on MJD
(S. Miguel, Azores, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018/09 - 2019/09 Targeted delivery of doxorubicin and C6-ceramide drug combinations to non-small cell lung cancer cells.
Coorientador
 Pharmaceutical Biotechnology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09 - 2019/09 Impact of nucleolin downregulation on the cellular and molecular features presented by breast cancer cells.
Coorientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09 - 2016/06 Astrocytic adenosine A2A receptors: novel targets to manage brain disorders.
Orientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/09/01 - 2015/09/07 Adenosine A2A receptors role in stress-induced neurobiological modifications.
Orientador
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/09 - 2015/09 Adenosine A2A receptors and stress-induced alterations in the rat ventral striatum.
Coorientador
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2010 - 2019 Brain Awareness Weeks: yearly organized by CNC sponsored by SPN), Ciência Viva Agency, FENS and The Dana Foundation. “Neuroscientists go to Schools” and “Open Laboratories” are organized in close collaboration with School clusters, the Science Museum, Science Center and local City Council.
Encontro
 Brain Awareness Weeks
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010 - 2019 Science and Technology weeks
Encontro
 Science and Technology weeks
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010 - 2019 Open Lab activities for teenager and young adult audiences; visiting children’s schools and receiving high school and undergraduated students in the laboratory.
Oficina (workshop)
 Open Lab Days
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2016/09/12 Astrocytic A2A receptors : novel targets to manage brain disorders.
Orientador
 Vanessa Jorge Henriques (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09/14 Adenosine A2A receptors role in stress-induced neurobiological modifications.
Orientador
 Sara Beatriz Gomes Fernandes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2012/01/30 - 2012/02/03 Gene and Cell Therapy of CNS: from microRNAs to IPS cells Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/11/01 - 2010/11/05 Cell Regulation and Signalling Doctoral Programme in Health Sciences (PhDHS) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/10/25 - 2010/10/29 Recombinant DNA Technology Master’s degree in Pharmaceutical Biotechnology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/04 - 2010/10/08 Research Methods and Techniques Doctoral Programme in Health Sciences (PhDHS) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Faculdade de Medicina, Portugal
Distinções

Prémio

2014 Junior Trainee Lecturer Award, AIM 2014 – 5th Ataxia Investigators Meeting
National Ataxia Foundation (NAF), Estados Unidos
2014 Best National Talent Award under 35 years old in Science at PrémiosNovos
Cego, Surdo e Mudo-Produções Multimédia, Portugal
2014 Best Paper Award in the category of Neurobiology of Diseases – 2014
Portuguese Society for Neuroscience, Portugal
2013 Best Paper Award in Neurobiology of Diseases – 2013
Portuguese Society for Neuroscience, Portugal

Outra distinção

2007 ERASMUS scholarship funded by the European Commission
Universidade de Coimbra, Portugal