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Identificação

Identificação pessoal

Nome completo
Serge Mignani

Identificadores de autor

Ciência ID
8018-B5D2-6983
Formação
Grau Classificação
1978/08/01 - 1981/08/31
Concluído
 Chemistry (Doctor)
Université catholique de Louvain, Bélgica
"Elaboration of the principle of bridged-dehydrodimerization according to the effect of the stabilization of captodatively substituted radicals" (TESE/DISSERTAÇÃO)
 Grade obtained: “Grande distinction” (highest honor)
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Professor Catedrático Convidado (Docente Universitário) Universidade da Madeira Faculdade de Ciências Exatas e da Engenharia, Portugal
Universidade da Madeira Centro de Química da Madeira, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2010 - 2017 Early-retirement position - Consultant and scientific advisory board member Sanofi Active Ingredient Solutions, França
2000 - 2010 Head Medicinal Chemistry Department and Scientific Director Sanofi Active Ingredient Solutions, França
1997 - 2000 Reseach Advisor « Directeur de Recherche Associé » Sanofi Active Ingredient Solutions, França
1994 - 1997 Department Director Sanofi Active Ingredient Solutions, França
1991 - 1994 Department Manager Sanofi Active Ingredient Solutions, França
1986 - 1991 Section Manager Sanofi Active Ingredient Solutions, França
1983 - 1985 Senior Research Scientist Sanofi Active Ingredient Solutions, França
1981 - 1983 Research Scientist Sanofi Active Ingredient Solutions, França
Projetos

Projeto

Designação Financiadores
2019/01/01 - 2019/12/31 Madeira Chemistry Research Centre
UID/QUI/00674/2019
Universidade da Madeira, Portugal

Universidade da Madeira Centro de Química da Madeira, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Apartsin, Evgeny; Akhir, Abdul; Kaul, Grace; Saxena, Deepanshi; Laurent, Regis; Srivastava, Kishore Kumar; Mignani, Serge; Majoral, Jean-Pierre; Chopra, Sidharth. Autor correspondente: Mignani, Serge. "Low-Generation Cationic Phosphorus Dendrimers: Novel Approach to Tackle Drug-Resistant S. aureus In Vitro and In Vivo". Biomacromolecules 24 7 (2023): 3215-3227. http://dx.doi.org/10.1021/acs.biomac.3c00266.
    Publicado • 10.1021/acs.biomac.3c00266
  2. Mangiatordi, Giuseppe Felice; Cavalluzzi, Maria Maddalena; Delre, Pietro; Lamanna, Giuseppe; Lumuscio, Maria Cristina; Saviano, Michele; Majoral, Jean-Pierre; et al. "Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective". Biomedicines 11 2 (2023): 469. http://dx.doi.org/10.3390/biomedicines11020469.
    Acesso aberto • Publicado • 10.3390/biomedicines11020469
  3. Yu, Zhibo; Tsapis, Nicolas; Fay, François; Chen, Liang; Karpus, Andrii; Shi, Xiangyang; Cailleau, Catherine; et al. "Amphiphilic Phosphorus Dendrons Associated with Anti-inflammatory siRNA Reduce Symptoms in Murine Collagen-Induced Arthritis". Biomacromolecules 24 2 (2023): 667-677. http://dx.doi.org/10.1021/acs.biomac.2c01117.
    Publicado • 10.1021/acs.biomac.2c01117
  4. Chen, Liang; Zhan, Mengsi; Li, Jin; Cao, Liu; Sun, Huxiao; Laurent, Régis; Mignani, Serge; et al. "Amphiphilic phosphorous dendron micelles co-deliver microRNA inhibitor and doxorubicin for augmented triple negative breast cancer therapy". Journal of Materials Chemistry B 11 24 (2023): 5483-5493. http://dx.doi.org/10.1039/d2tb02114e.
    Publicado • 10.1039/d2tb02114e
  5. Li, Jin; Chen, Liang; Sun, Huxiao; Zhan, Mengsi; Laurent, Regis; Mignani, Serge; Majoral, Jean-Pierre; Shen, Mingwu; Shi, Xiangyang. "Cationic phosphorus dendron nanomicelles deliver microRNA mimics and microRNA inhibitors for enhanced anti-inflammatory therapy of acute lung injury". Biomaterials Science 11 4 (2023): 1530-1539. http://dx.doi.org/10.1039/d2bm01807a.
    Publicado • 10.1039/d2bm01807a
  6. Karpus, A.; Mignani, S.; Apartsin, E.; Zablocka, M.; Shi, X.; Majoral, J. P.. Autor correspondente: Mignani, S.. "Useful synthetic pathways to original, stable tunable neutral and anionic phosphorus dendrimers: new opportunities to expand dendrimer space". New Journal of Chemistry 47 5 (2023): 2474-2478. http://dx.doi.org/10.1039/d2nj05157e.
    Publicado • 10.1039/d2nj05157e
  7. Zhan, Mengsi; Wang, Dayuan; Zhao, Lingzhou; Chen, Liang; Ouyang, Zhijun; Mignani, Serge; Majoral, Jean-Pierre; et al. "Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters". Biomaterials Science 11 22 (2023): 7387-7396. http://dx.doi.org/10.1039/d3bm01198d.
    Publicado • 10.1039/d3bm01198d
  8. Sun, Huxiao; Zhan, Mengsi; Mignani, Serge; Shcharbin, Dzmitry; Majoral, Jean-Pierre; Rodrigues, João; Shi, Xiangyang; Shen, Mingwu. "Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review". Pharmaceutics 14 10 (2022): 2239. http://dx.doi.org/10.3390/pharmaceutics14102239.
    Acesso aberto • Publicado • 10.3390/pharmaceutics14102239
  9. Terehova, Maria; Magiera, Jakub; Qiu, Jieru; Majoral, Jean-Pierre; Shi, Xiangyang; Mignani, Serge; Ionov, Maksim; et al. "Effect of amphiphilic phosphorous dendrons on the conformation, secondary structure, and zeta potential of albumin and thrombin". Polymer Bulletin 80 8 (2022): 9181-9193. http://dx.doi.org/10.1007/s00289-022-04512-8.
    Publicado • 10.1007/s00289-022-04512-8
  10. Chen, Liang; Cao, Liu; Zhan, Mengsi; Li, Jin; Wang, Dayuan; Laurent, Régis; Mignani, Serge; et al. Autor correspondente: Mignani, Serge. "Engineered Stable Bioactive Per Se Amphiphilic Phosphorus Dendron Nanomicelles as a Highly Efficient Drug Delivery System To Take Down Breast Cancer In Vivo". Biomacromolecules 23 7 (2022): 2827-2837. http://dx.doi.org/10.1021/acs.biomac.2c00197.
    Publicado • 10.1021/acs.biomac.2c00197
  11. Mignani, Serge; Shi, Xiangyang; Rodrigues, João; Tomás, Helena; Majoral, Jean-Pierre; Rodrigues, Joao; Tomas, Helena. "Dendrimer nanoplatforms for veterinary medicine applications: A concise overview". Drug Discovery Today 27 5 (2022): 1251-1260. http://dx.doi.org/10.1016/j.drudis.2022.01.001.
    Publicado • 10.1016/j.drudis.2022.01.001
  12. Posadas, Inmaculada; Romero-Castillo, Laura; Ronca, Rosa-Anna; Karpus, Andrii; Mignani, Serge; Majoral, Jean-Pierre; Muñoz-Fernández, Mariángeles; Ceña, Valentín. "Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death". International Journal of Molecular Sciences 23 8 (2022): 4391. http://dx.doi.org/10.3390/ijms23084391.
    Acesso aberto • Publicado • 10.3390/ijms23084391
  13. Gupta, Ria; Sharma, Sumit; Singh, Rohit; Vishwakarma, Ram A.; Mignani, Serge; Singh, Parvinder Pal. "Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950–2021 Comprehensive Overview". Pharmaceuticals 15 5 (2022): 561. http://dx.doi.org/10.3390/ph15050561.
    Acesso aberto • Aceite para publicação • 10.3390/ph15050561
  14. Travers--Lesage, Valentin; Mignani, Serge M.; Dallemagne, Patrick; Rochais, Christophe. "Advances in prodrug design for Alzheimer’s disease: the state of the art". Expert Opinion on Drug Discovery 17 4 (2022): 325-341. http://dx.doi.org/10.1080/17460441.2022.2031972.
    10.1080/17460441.2022.2031972
  15. Li, Jin; Chen, Liang; Li, Changsheng; Fan, Yu; Zhan, Mengsi; Sun, Huxiao; Mignani, Serge; et al. "Phosphorus dendron nanomicelles as a platform for combination anti-inflammatory and antioxidative therapy of acute lung injury". Theranostics 12 7 (2022): 3407-3419. http://dx.doi.org/10.7150/thno.70701.
    10.7150/thno.70701
  16. Mignani, Serge; Shi, Xiangyang; Ceña, Valentin; Rodrigues, João; Tomás, Helena; Majoral, Jean-Pierre. "Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio)pharmaceuticals in cancer therapy". (2021): http://hdl.handle.net/10400.13/4087.
    10.1016/j.jconrel.2021.03.003
  17. Gonçalves, Mara; Mignani, Serge; Rodrigues, João; Tomás, Helena. "A glance over doxorubicin based-nanotherapeutics: from proof-of-concept studies to solutions in the market". (2020): http://hdl.handle.net/10400.13/3650.
    10.1016/j.jconrel.2019.11.016
  18. Mignani, Serge; Shi, Xiangyang; Rodrigues, João; Roy, René; Muñoz-Fernández, Ángeles; Ceña, Valentin; Majoral, Jean Pierre. "Dendrimers toward translational nanotherapeutics: concise key step analysis". (2020): http://hdl.handle.net/10400.13/4092.
    10.1021/acs.bioconjchem.0c00395
  19. Song, Cong; Shen, Mingwu; Rodrigues, João; Mignani, Serge; Majoral, Jean-Pierre; Shi, Xiangyang. "Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review". (2020): http://hdl.handle.net/10400.13/4097.
    10.1016/j.ccr.2020.213463
  20. Mignani, Serge; Rodrigues, João; Roy, René; Shi, Xiangyang; Ceña, Valentin; El Kazzouli, Saïd; Majoral, Jean-Pierre. "Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)". (2019): http://hdl.handle.net/10400.13/2444.
    10.1016/j.drudis.2019.02.014
  21. Li, Aijun; Fan, Yu; Cao, Xueyan; Chen, Liang; Wang, Le; Alves, Carla S.; Mignani, Serge; et al. "Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells". (2019): http://hdl.handle.net/10400.13/4328.
    10.1039/C9NR06410A
  22. Mignani, Serge; Rodrigues, João; Tomás, Helena; Zablocka, Maria; Shi, Xiangyang; Caminade, Anne-marie; Majoral, Jean-Pierre. "Dendrimers in combination with natural products and analogues as anti-cancer agents". (2018): http://hdl.handle.net/10400.13/2434.
    10.1039/c7cs00550d
  23. Mignani, Serge; Rodrigues, João; Tomás, Helena; Roy, René; Shi, Xiangyang; Majoral, Jean-Pierre. "Bench-to-bedside translation of dendrimers: reality or utopia? A concise analysis". (2018): http://hdl.handle.net/10400.13/2439.
    10.1016/j.addr.2017.11.007
  24. Mignani, Serge; Rodrigues, João; Tomás, Helena; Caminade, Anne-marie; Laurent, Régis; Shi, Xiangyang; Majoral, Jean-Pierre. "Recent therapeutic applications of the theranostic principle with dendrimers in oncology". (2018): http://hdl.handle.net/10400.13/2440.
    10.1007/s40843-018-9244-5
  25. Mignani, Serge; Rodrigues, João; Tomás, Helena; Jalal, Rachid; Singh, Parvinder Pal; Majoral, Jean-Pierre; Vishwakarma, Ram A.. "Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?". (2018): http://hdl.handle.net/10400.13/2436.
    10.1016/j.drudis.2018.01.010
  26. Dabrzalska, M.; Janaszewska, A.; Zablocka, M.; Mignani, S.; Majoral, J.P.; Klajnert-Maculewicz, B.. "Cationic Phosphorus Dendrimer Enhances Photodynamic Activity of Rose Bengal against Basal Cell Carcinoma Cell Lines". Molecular Pharmaceutics 14 5 (2017): 1821-1830. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018397197&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.7b00108
  27. Shcharbin, D.; Shcharbina, N.; Dzmitruk, V.; Pedziwiatr-Werbicka, E.; Ionov, M.; Mignani, S.; de la Mata, F.J.; et al. "Dendrimer-protein interactions versus dendrimer-based nanomedicine". Colloids and Surfaces B: Biointerfaces 152 (2017): 414-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012273146&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.01.041
  28. Wen, S.; Zhao, L.; Zhao, Q.; Li, D.; Liu, C.; Yu, Z.; Shen, M.; et al. "A promising dual mode SPECT/CT imaging platform based on99mTc-labeled multifunctional dendrimer-entrapped gold nanoparticles". Journal of Materials Chemistry B 5 21 (2017): 3810-3815. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021755371&partnerID=MN8TOARS.
    10.1039/c7tb00543a
  29. Bohr, A.; Tsapis, N.; Andreana, I.; Chamarat, A.; Foged, C.; Delomenie, C.; Noiray, M.; et al. "Anti-Inflammatory Effect of Anti-TNF-a SiRNA Cationic Phosphorus Dendrimer Nanocomplexes Administered Intranasally in a Murine Acute Lung Injury Model". Biomacromolecules 18 8 (2017): 2379-2388. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027332338&partnerID=MN8TOARS.
    10.1021/acs.biomac.7b00572
  30. Posadas, I.; Romero-Castillo, L.; El Brahmi, N.; Manzanares, D.; Mignani, S.; Majoral, J.-P.; Ceña, V.. "Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo". Proceedings of the National Academy of Sciences of the United States of America 114 37 (2017): E7660-E7669. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029415109&partnerID=MN8TOARS.
    10.1073/pnas.1704858114
  31. Mignani, S.; El Brahmi, N.; Eloy, L.; Poupon, J.; Nicolas, V.; Steinmetz, A.; El Kazzouli, S.; et al. "Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators". European Journal of Medicinal Chemistry 132 (2017): 142-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016063895&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.03.035
  32. Dabrzalska, M.; Janaszewska, A.; Zablocka, M.; Mignani, S.; Majoral, J.P.; Klajnert-Maculewicz, B.. "Complexing methylene blue with phosphorus dendrimers to increase photodynamic activity". Molecules 22 3 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85014491502&partnerID=MN8TOARS.
    10.3390/molecules22030345
  33. El Brahmi, N.; El Kazzouli, S.; Mignani, S.; Laurent, R.; Ladeira, S.; Caminade, A.-M.; Bousmina, M.; Majoral, J.-P.. "Symmetrical and unsymmetrical incorporation of active biological monomers on the surface of phosphorus dendrimers". Tetrahedron 73 10 (2017): 1331-1341. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011032590&partnerID=MN8TOARS.
    10.1016/j.tet.2017.01.044
  34. Mignani, S.M.; El Brahmi, N.; El Kazzouli, S.; Laurent, R.; Ladeira, S.; Caminade, A.-M.; Pedziwiatr-Werbicka, E.; et al. "Original Multivalent Gold(III) and Dual Gold(III)-Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents". Molecular Pharmaceutics 14 11 (2017): 4087-4097. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033369173&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.7b00771
  35. Mignani, S.; Bryszewska, M.; Zablocka, M.; Klajnert-Maculewicz, B.; Cladera, J.; Shcharbin, D.; Majoral, J.-P.. "Can dendrimer based nanoparticles fight neurodegenerative diseases? Current situation versus other established approaches". Progress in Polymer Science 64 (2017): 23-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999648371&partnerID=MN8TOARS.
    10.1016/j.progpolymsci.2016.09.006
  36. Mignani, Serge; Huber, Scot; Tomás, Helena; Rodrigues, João; Majoral, Jean-Pierre. "Compound high-quality criteria: a new vision to guide the development of drugs, current situation". (2016): http://hdl.handle.net/10400.13/2428.
    10.1016/j.drudis.2016.01.005
  37. Sun, W.; Mignani, S.; Shen, M.; Shi, X.. "Dendrimer-based magnetic iron oxide nanoparticles: their synthesis and biomedical applications". Drug Discovery Today 21 12 (2016): 1873-1885. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979581734&partnerID=MN8TOARS.
    10.1016/j.drudis.2016.06.028
  38. Mignani, S.; El Brahmi, N.; El Kazzouli, S.; Eloy, L.; Courilleau, D.; Caron, J.; Bousmina, M.M.; et al. "A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action". European Journal of Medicinal Chemistry 122 (2016): 656-673. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978505275&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.05.063
  39. Zablocka, M.; Oshovsky, G.; Duhayon, C.; Ladeira, S.; Caminade, A.-M.; Mignani, S.; Majoral, J.-P.. "Thiazoyl phosphines. Design, reactivity, and complexation". Dalton Transactions 45 23 (2016): 9695-9703. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973884857&partnerID=MN8TOARS.
    10.1039/c6dt01106c
  40. Dabrzalska, M.; Benseny-Cases, N.; Barnadas-Rodríguez, R.; Mignani, S.; Zablocka, M.; Majoral, J.-P.; Bryszewska, M.; Klajnert-Maculewicz, B.; Cladera, J.. "Fourier transform infrared spectroscopy (FTIR) characterization of the interaction of anti-cancer photosensitizers with dendrimers". Analytical and Bioanalytical Chemistry 408 2 (2016): 535-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954400424&partnerID=MN8TOARS.
    10.1007/s00216-015-9125-0
  41. Mignani, S.; Huber, S.; Tomás, H.; Rodrigues, J.; Majoral, J.-P.. "Why and how have drug discovery strategies in pharma changed? What are the new mindsets?". Drug Discovery Today 21 2 (2016): 239-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950162061&partnerID=MN8TOARS.
    10.1016/j.drudis.2015.09.007
  42. Li, D.; Zhang, Y.; Wen, S.; Song, Y.; Tang, Y.; Zhu, X.; Shen, M.; et al. "Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: An innovative theranostic strategy". Journal of Materials Chemistry B 4 23 (2016): 4216-4226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974627333&partnerID=MN8TOARS.
    10.1039/c6tb00773b
  43. Mignani, S.; Bryszewska, M.; Klajnert-Maculewicz, B.; Zablocka, M.; Majoral, J.-P.. "Advances in combination therapies based on nanoparticles for efficacious cancer treatment: An analytical report". Biomacromolecules 16 1 (2015): 1-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920883861&partnerID=MN8TOARS.
    10.1021/bm501285t
  44. Shcharbin, D.; Shcharbina, N.; Shakhbazau, A.; Mignani, S.; Majoral, J.-P.; Bryszewska, M.. "Phosphorus-containing nanoparticles: Biomedical patents review". Expert Opinion on Therapeutic Patents 25 5 (2015): 539-548. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928236715&partnerID=MN8TOARS.
    10.1517/13543776.2015.1010512
  45. Shakhbazau, A.; Mishra, M.; Chu, T.-H.; Brideau, C.; Cummins, K.; Tsutsui, S.; Shcharbin, D.; et al. "Fluorescent Phosphorus Dendrimer as a Spectral Nanosensor for Macrophage Polarization and Fate Tracking in Spinal Cord Injury". Macromolecular Bioscience 15 11 (2015): 1523-1534. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945302230&partnerID=MN8TOARS.
    10.1002/mabi.201500150
  46. Luo, Y.; Yang, J.; Yan, Y.; Li, J.; Shen, M.; Zhang, G.; Mignani, S.; Shi, X.. "RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T<inf>1</inf>-weighted MR imaging of gliomas". Nanoscale 7 34 (2015): 14538-14546. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939857096&partnerID=MN8TOARS.
    10.1039/c5nr04003e
  47. Dabrzalska, M.; Zablocka, M.; Mignani, S.; Majoral, J.P.; Klajnert-Maculewicz, B.. "Phosphorus dendrimers and photodynamic therapy. Spectroscopic studies on two dendrimer-photosensitizer complexes: Cationic phosphorus dendrimer with rose bengal and anionic phosphorus dendrimer with methylene blue". International Journal of Pharmaceutics 492 1-2 (2015): 266-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938149993&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2015.06.014
  48. Dzmitruk, V.; Szulc, A.; Shcharbin, D.; Janaszewska, A.; Shcharbina, N.; Lazniewska, J.; Novopashina, D.; et al. "Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action". International Journal of Pharmaceutics 485 1-2 (2015): 288-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925308770&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2015.03.034
  49. El Brahmi, N.; Mignani, S.M.; Caron, J.; El Kazzouli, S.; Bousmina, M.M.; Caminade, A.-M.; Cresteil, T.; Majoral, J.-P.. "Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs". Nanoscale 7 9 (2015): 3915-3922. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923378901&partnerID=MN8TOARS.
    10.1039/c4nr05983b
  50. Katir, N.; El Brahmi, N.; El Kadib, A.; Mignani, S.; Caminade, A.-M.; Bousmina, M.; Majoral, J.P.. "Synthesis of onion-peel nanodendritic structures with sequential functional phosphorus diversity". Chemistry - A European Journal 21 17 (2015): 6400-6408. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926616592&partnerID=MN8TOARS.
    10.1002/chem.201500138
  51. Milowska, K.; Szwed, A.; Zablocka, M.; Caminade, A.-M.; Majoral, J.-P.; Mignani, S.; Gabryelak, T.; Bryszewska, M.. "In vitro PAMAM, phosphorus and viologen-phosphorus dendrimers prevent rotenone-induced cell damage". International Journal of Pharmaceutics 474 1-2 (2014): 42-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906074884&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2014.08.010
  52. Lecoutey, C.; Hedou, D.; Freret, T.; Giannoni, P.; Gaven, F.; Since, M.; Bouet, V.; et al. "Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment". Proceedings of the National Academy of Sciences of the United States of America 111 36 (2014): E3825-E3830. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907001204&partnerID=MN8TOARS.
    10.1073/pnas.1410315111
  53. Shcharbin, D.; Shcharbina, N.; Milowska, K.; de la Mata, F.J.; Muñoz-Fernandez, M.A.; Mignani, S.; Gomez-Ramirez, R.; Majoral, J.-P.; Bryszewska, M.. "Interference of cationic polymeric nanoparticles with clinical chemistry tests--clinical relevance". International journal of pharmaceutics 473 1-2 (2014): 599-606. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027943890&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2014.07.054
  54. Mignani, S.; El Kazzouli, S.; Bousmina, M.M.; Majoral, J.-P.. "Dendrimer space exploration: An assessment of dendrimers/dendritic scaffolding as inhibitors of protein-protein interactions, a potential new area of pharmaceutical development". Chemical Reviews 114 2 (2014): 1327-1342. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893107412&partnerID=MN8TOARS.
    10.1021/cr400362r
  55. Ottaviani, M.F.; El Brahmi, N.; Cangiotti, M.; Coppola, C.; Buccella, F.; Cresteil, T.; Mignani, S.; et al. "Comparative EPR studies of Cu(ii)-conjugated phosphorous-dendrimers in the absence and presence of normal and cancer cells". RSC Advances 4 69 (2014): 36573-36583. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906674378&partnerID=MN8TOARS.
    10.1039/c4ra06066k
  56. Lazniewska, J.; Janaszewska, A.; Milowska, K.; Caminade, A.-M.; Mignani, S.; Katir, N.; Kadib, A.E.; et al. "Promising low-toxicity of viologen-phosphorus dendrimers against embryonic mouse hippocampal cells". Molecules 18 10 (2013): 12222-12240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886635770&partnerID=MN8TOARS.
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  57. Mignani, S.; El Kazzouli, S.; Bousmina, M.; Majoral, J.-P.. "Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: A concise overview". Advanced Drug Delivery Reviews 65 10 (2013): 1316-1330. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885386826&partnerID=MN8TOARS.
    10.1016/j.addr.2013.01.001
  58. El Brahmi, N.; El Kazzouli, S.; Mignani, S.M.; Essassi, E.M.; Aubert, G.; Laurent, R.; Caminade, A.-M.; et al. "Original multivalent copper(II)-conjugated phosphorus dendrimers and corresponding mononuclear copper(II) complexes with antitumoral activities". Molecular Pharmaceutics 10 4 (2013): 1459-1464. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875764628&partnerID=MN8TOARS.
    10.1021/mp4000184
  59. El Brahmi, N.; El Kazzouli, S.; Mignani, S.; Bousmina, M.; Majoral, J.P.. "Copper in dendrimer synthesis and applications of copper-dendrimer systems in catalysis: A concise overview". Tetrahedron 69 15 (2013): 3103-3133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875212402&partnerID=MN8TOARS.
    10.1016/j.tet.2013.02.019
  60. Mignani, S.; Kazzouli, S.E.; Bousmina, M.; Majoral, J.-P.. "Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry". Progress in Polymer Science 38 7 (2013): 993-1008. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878895972&partnerID=MN8TOARS.
    10.1016/j.progpolymsci.2013.03.003
  61. Mignani, S.; Majoral, J.-P.. "Dendrimers as macromolecular tools to tackle from colon to brain tumor types: A concise overview". New Journal of Chemistry 37 11 (2013): 3337-3357. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885693002&partnerID=MN8TOARS.
    10.1039/c3nj00300k
  62. Lazniewska, J.; Milowska, K.; Zablocka, M.; Mignani, S.; Caminade, A.-M.; Majoral, J.-P.; Bryszewska, M.; Gabryelak, T.. "Mechanism of cationic phosphorus dendrimer toxicity against murine neural cell lines". Molecular Pharmaceutics 10 9 (2013): 3484-3496. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883565434&partnerID=MN8TOARS.
    10.1021/mp4003255
  63. El Kazzouli, S.; El Brahmi, N.; Mignani, S.; Bousmina, M.; Zablocka, M.; Majoral, J.-P.. "From metallodrugs to metallodendrimers for nanotherapy in oncology: A concise overview". Current Medicinal Chemistry 19 29 (2012): 4995-5010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870420716&partnerID=MN8TOARS.
    10.2174/0929867311209024995
  64. El Kazzouli, S.; Mignani, S.; Bousmina, M.; Majoral, J.-P.. "Dendrimer therapeutics: Covalent and ionic attachments". New Journal of Chemistry 36 2 (2012): 227-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856704956&partnerID=MN8TOARS.
    10.1039/c1nj20459a
  65. Amela-Cortes, M.; Roullier, V.; Wolpert, C.; Neubauer, S.; Kessler, H.; Bedel, O.; Mignani, S.; Marchi-Artzner, V.. "Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry". Chemical Communications 47 4 (2011): 1246-1248. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651313712&partnerID=MN8TOARS.
    10.1039/c0cc03753b
  66. Mignani, S.; Aszodi, J.; Babin, D.; Liutkus, M.; Bedel, O.. "Synthesis of new macromolecular, functionalized carboxylic-acid-PEG-DHLA surface ligands". Tetrahedron Letters 51 41 (2010): 5364-5367. http://www.scopus.com/inward/record.url?eid=2-s2.0-84755161804&partnerID=MN8TOARS.
    10.1016/j.tetlet.2010.07.118
  67. Coantic, S.; Mouysset, D.; Mignani, S.; Tabart, M.; Stella, L.. "The use of N-sulfenylimines in the ß-lactam synthon method: Staudinger reaction, oxidation of the cycloadducts and ring opening of ß-lactams". Tetrahedron 63 15 (2007): 3205-3216. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847664294&partnerID=MN8TOARS.
    10.1016/j.tet.2007.01.051
  68. Coantic, S.; Mouysset, D.; Mignani, S.; Tabart, M.; Stella, L.. "Stereoselective synthesis of trans-disubstituted-ß-lactams from N-phenylsulfenylimines". Tetrahedron Letters 48 24 (2007): 4301-4303. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248585918&partnerID=MN8TOARS.
    10.1016/j.tetlet.2007.04.012
  69. Canova, S.; Bellosta, V.; Bigot, A.; Mailliet, P.; Mignani, S.; Cossy, J.. "Total synthesis of herbimycin A". Organic Letters 9 1 (2007): 145-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846451033&partnerID=MN8TOARS.
    10.1021/ol062642i
  70. Cariou, K.; Ronan, B.; Mignani, S.; Fensterbank, L.; Malacria, M.. "From PtCl2- and acid-catalyzed to uncatalyzed cycloisomerization of 2-propargyl anilines: Access to functionalized indoles". Angewandte Chemie - International Edition 46 11 (2007): 1881-1884. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249686688&partnerID=MN8TOARS.
    10.1002/anie.200604026
  71. Canova, S.; Bellosta, V.; Mignani, S.; Bigot, A.; Cossy, J.. "Rearrangement of homoallylic alcohols induced by DAST". Organic Letters 8 10 (2006): 2091-2094. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744779402&partnerID=MN8TOARS.
    10.1021/ol060529m
  72. Carry, J.-C.; Evers, M.; Barrière, J.-C.; Bashiardes, G.; Bensoussan, C.; Gueguen, J.-C.; Dereu, N.; et al. "Semisynthetic Di- and Tri-Functionalized Non-Immunosuppressive Cyclosporin A Derivatives as Potential Anti-HIV 1 Drugs". Synlett 2 (2004): 316-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-10744232420&partnerID=MN8TOARS.
  73. Stutzmann, J.-M.; Vuilhorgne, M.; Mignani, S.. "Synthesis and structure-activity relationships of 4,10-dihydro-4-oxo-4H-imidazo [1,2-a]indeno [1,2-e]pyrazine derivatives: Highly potent and selective AMPA receptor antagonists with in vivo activity". Mini-Reviews in Medicinal Chemistry 4 2 (2004): 123-140. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042843644&partnerID=MN8TOARS.
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  74. Evers, M.; Barrière, J.-C.; Bashiardes, G.; Bousseau, A.; Carry, J.-C.; Dereu, N.; Filoche, B.; et al. "Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin a derivatives as potential anti-HIV-1 drugs". Bioorganic and Medicinal Chemistry Letters 13 24 (2003): 4415-4419. http://www.scopus.com/inward/record.url?eid=2-s2.0-10744221220&partnerID=MN8TOARS.
    10.1016/j.bmcl.2003.09.042
  75. Vuilhorgne, M.; Malpart, J.; Mutti, S.; Mignani, S.. "Preparative route to 2-ethoxycarbonylimidazole-4-phosphonate and diethyl imidazole-2,4-dicarboxylate". Journal of Heterocyclic Chemistry 40 1 (2003): 159-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037288191&partnerID=MN8TOARS.
  76. Le Roy, I.; Mouysset, D.; Mignani, S.; Vuilhorgne, M.; Stella, L.. "Solid phase ß-lactams synthesis using the Staudinger reaction, monitored by19F NMR spectroscopy". Tetrahedron 59 21 (2003): 3719-3727. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038061451&partnerID=MN8TOARS.
    10.1016/S0040-4020(03)00553-2
  77. Genevois-Borella, A.; Vuilhorgne, M.; Mignani, S.. "A preparative route to fused 4-hydroxy-3-phenylindeno(benzothieno)pyridin-2-ones". Heterocycles 57 2 (2002): 317-322. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036470645&partnerID=MN8TOARS.
  78. Mignani, S.; Bohme, G.A.; Birraux, G.; Boireau, A.; Jimonet, P.; Damour, D.; Genevois-Borella, A.; et al. "9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): Selective anticonvulsive and neuroprotective AMPA antagonist". Bioorganic and Medicinal Chemistry 10 5 (2002): 1627-1637. http://www.scopus.com/inward/record.url?eid=2-s2.0-18344378047&partnerID=MN8TOARS.
    10.1016/S0968-0896(01)00431-X
  79. Stutzmann, J.-M.; Bohme, G.A.; Boireau, A.; Damour, D.; Debono, M.W.; Genevois-Borella, A.; Jimonet, P.; et al. "Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives". Bioorganic and Medicinal Chemistry Letters 11 9 (2001): 1205-1210. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035821370&partnerID=MN8TOARS.
    10.1016/S0960-894X(01)00180-9
  80. Canton, T.; Böhme, G.A.; Boireau, A.; Bordier, F.; Mignani, S.; Jimonet, P.; Jahn, G.; et al. "RPR 119990, a novel a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: Synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis". Journal of Pharmacology and Experimental Therapeutics 299 1 (2001): 314-322. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034802145&partnerID=MN8TOARS.
  81. Vuilhorgne, M.; Bouquerel, J.; Hardy, J.-C.; Mignani, S.. "A preparative route to ethyl 3-(2-ethoxycarbonyl-1H-imidazol-4-yl) propenoate and propanoate". Synlett 1 (2001): 135-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035133354&partnerID=MN8TOARS.
  82. Jimonet, P.; Bohme, G.A.; Bouquerel, J.; Boireau, A.; Damour, D.; Debono, M.W.; Genevois-Borella, A.; et al. "Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1, 2-a]indeno-[1, 2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action". Bioorganic and Medicinal Chemistry Letters 11 2 (2001): 127-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035931586&partnerID=MN8TOARS.
    10.1016/S0960-894X(00)00592-8
  83. Mignani, S.; Bohme, G.A.; Boireau, A.; Cheve, M.; Damour, D.; Debono, M.-W.; Genevois-Borella, A.; et al. "8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazines : Highly potent in vivo AMPA antagonists". Bioorganic and Medicinal Chemistry Letters 10 6 (2000): 591-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-17344388678&partnerID=MN8TOARS.
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  84. Jimonet, P.; Chevé, M.; Andrees Bohme, G.; Boireau, A.; Damour, D.; Williams Debono, M.; Genevois-Borella, A.; et al. "8-Methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-ones: Highly in vivo potent and selective AMPA receptor antagonists". Bioorganic and Medicinal Chemistry 8 8 (2000): 2211-2217. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033859991&partnerID=MN8TOARS.
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  85. Jimonet, P.; Ribeill, Y.; Bohme, G.A.; Boireau, A.; Chevé, M.; Damour, D.; Doble, A.; et al. "Indeno[1,2-b]pyrazin-2,3-diones: A new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity". Journal of Medicinal Chemistry 43 12 (2000): 2371-2381. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033947294&partnerID=MN8TOARS.
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  86. Pratt, J.; Jimonet, P.; Bohme, G.A.; Boireau, A.; Damour, D.; Debono, M.W.; Genevois-Borella, A.; et al. "Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]indeno[1,2-e]pyrazin-8- and-9-carboxylic (acetic) acid AMPA antagonists". Bioorganic and Medicinal Chemistry Letters 10 24 (2000): 2749-2754. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034684750&partnerID=MN8TOARS.
    10.1016/S0960-894X(00)00561-8
  87. Mignani, S.; Mouysset, D.; Roy, I.L.; Stella, L.. "Stereoselective cycloaddition of monosubstituted ketene to a methyl glyoxylate- and threonine-derived imine: Synthesis of optically pure ß-lactamic a-amino ester with high functionality". Synthetic Communications 30 20 (2000): 3685-3691. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033801807&partnerID=MN8TOARS.
    10.1080/00397910008086995
  88. Stutzmann, J.-M.; Bohme, G.A.; Boireau, A.; Damour, D.; Debono, M.W.; Genevois-Borella, A.; Imperato, A.; et al. "4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: Highly potent and selective AMPA receptors antagonists with in vivo activity". Bioorganic and Medicinal Chemistry Letters 10 10 (2000): 1133-1137. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034658574&partnerID=MN8TOARS.
    10.1016/S0960-894X(00)00181-5
  89. Damour, D.; Doerflinger, G.; Pantel, G.; Labaudinière, R.; Leconte, J.-P.; Sablé, S.; Vuilhorgne, M.; Mignani, S.. "A convenient synthetic route to macrocyclic cis-3-phenylproline derivatives as mimics of Sandostatin®". Synlett 2 (1999): 189-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032962813&partnerID=MN8TOARS.
  90. Mignani, S.; Aloup, J.-C.; Barreau, M.; Blanchard, J.C.; Böhme, G.A.; Boireau, A.; Damour, D.; et al. "Synthesis and pharmacological properties of 5H,10H-imidazo[1,2- a]indeno[1,2-e]pyrazine,4-one, a new competitive AMPA/KA receptor antagonist". Drug Development Research 48 3 (1999): 121-129. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033388441&partnerID=MN8TOARS.
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  91. Gauzy, L.; Le Merrer, Y.; Depezay, J.-C.; Damour-Barbalat, D.; Mignani, S.. "Synthesis of C2-symmetric bis(cyclic isothioureas) as potent inhibitors of glycosidases". Tetrahedron Letters 40 19 (1999): 3705-3708. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033531983&partnerID=MN8TOARS.
    10.1016/S0040-4039(99)00593-6
  92. Damour, D.; Herman, F.; Labaudinière, R.; Pantel, G.; Vuilhorgne, M.; Mignani, S.. "Synthesis of novel proline and ¿-lactam derivatives as non-peptide mimics of Somatostatin/Sandostatin®". Tetrahedron 55 33 (1999): 10135-10154. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033551723&partnerID=MN8TOARS.
    10.1016/S0040-4020(99)00561-X
  93. Jimonet, P.; Boireau, A.; Chevé, M.; Damour, D.; Genevois-Borella, A.; Imperato, A.; Pratt, J.; et al. "Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo.". Bioorganic and Medicinal Chemistry Letters 9 20 (1999): 2921-2926. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033581566&partnerID=MN8TOARS.
    10.1016/S0960-894X(99)00502-8
  94. Damour, D.; Aloup, J.-C.; Barreau, M.; Genevois-Borella, A.; Jimonet, P.; Leconte, J.-P.; Ribeill, Y.; Vuilhorgne, M.; Mignani, S.. "An efficient preparative route to fused imidazo[1,2-a]pyrazin-4-one derivatives". Heterocycles 50 1 (1999): 259-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032837959&partnerID=MN8TOARS.
  95. Jimonet, P.; Audiau, F.; Barreau, M.; Blanchard, J.-C.; Boireau, A.; Bour, Y.; Coléno, M.-A.; et al. "Riluzole series. synthesis and in vivo 'antiglutamate' activity of 6- substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines". Journal of Medicinal Chemistry 42 15 (1999): 2828-2843. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033614947&partnerID=MN8TOARS.
    10.1021/jm980202u
  96. Ribeill, Y.; Genevois-Borella, A.; Vuilhorgne, M.; Mignani, S.. "A preparative route to fused indeno[1,2-e][1,2,4]-triazolo[4,3- a]pyrazin-4-ones". Heterocycles 51 12 (1999): 2977-2982. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033373376&partnerID=MN8TOARS.
  97. Damour, D.; Pulicani, J.-P.; Vuilhorgne, M.; Mignani, S.. "cis- and trans-3-(3-indolyl)proline derivatives as conformationally restricted analogues of tryptophan". Synlett 6 (1999): 786-788. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033040773&partnerID=MN8TOARS.
  98. Vuilhorgne, M.; Commerçon, A.; Mignani, S.. "A convenient method for the preparation of 3-azetidinylidene acetic acid". Chemistry Letters 7 (1999): 605-606. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033245483&partnerID=MN8TOARS.
  99. Gauzy, L.; Merrer, Y.L.; Depezay, J.-C.; Clerc, F.; Mignani, S.. "Synthesis of azepane scaffolds on solid support for combinatorial chemistry". Tetrahedron Letters 40 33 (1999): 6005-6008. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033551756&partnerID=MN8TOARS.
    10.1016/S0040-4039(99)01247-2
  100. Keglevich, G.; Trecska, M.; Újszászy, K.; Ludányi, K.; Szöllosy, Á.; Toke, L.; Mignani, S.. "Synthesis of six-membered silaheterocycles by the ring enlargement of 1,1-diphenyl-1-silacyclopent-3-ene". Heteroatom Chemistry 10 2 (1999): 171-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-6444229329&partnerID=MN8TOARS.
    10.1002/(SICI)1098-1071(1999)10:2<171::AID-HC12>3.0.CO;2-X
  101. Damour, D.; Barreau, M.; Blanchard, J.-C.; Burgevin, M.-C.; Doble, A.; Pantel, G.; Labaudinière, R.; Mignani, S.. "Synthesis and binding affinities of novel spirocyclic lactam peptidomimetics of somatostatin". Chemistry Letters 9 (1998): 943-944. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032356361&partnerID=MN8TOARS.
  102. Damour, D.; Barreau, M.; Fardin, V.; Dhaleine, F.; Vuilhorgne, M.; Mignani, S.. "1,3-dipolar cycloaddition reactions of 4-silacyclohex(hept)-2-en-1-one derivatives: Synthesis of novel azasilabicyclic compounds". Synlett 2 (1998): 153-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038818428&partnerID=MN8TOARS.
  103. Mignani, S.; Barreau, M.; Damour, D.; Renaudon, A.; Dejean, V.; Manuel, G.. "Construction of 2,3- and 3,4-functionalized silacyclopentanes: Synthesis of 6-aza-2,2-diphenyl-2-silabicyclo[3.1.0]hexane and 6-aza-3,3-diphenyl-3- silabicyclo[3.1.0]hexane derivatives". Synthetic Communications 28 7 (1998): 1163-1173. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031920856&partnerID=MN8TOARS.
  104. Barreau, M.; Commerçon, A.; Mignani, S.; Mouysset, D.; Perfetti, P.; Stella, L.. "Stereoselective synthesis of racemic a-amino-acid derivatives with a ß-lactam skeleton: Application of the Staudinger reaction to chiral imines of methyl glyoxylate". Tetrahedron 54 38 (1998): 11501-11516. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032541591&partnerID=MN8TOARS.
  105. Damour, D.; Doerflinger, G.; Mignani, S.. "(3aR*, 6aS*)-5,5-dipiienyl-2, 3, 3a, 4, 6, 6a-hexahydrosilolano[3,4-b]furan-2-one: A new fused ¿-butyrolactone". Heterocycles 45 5 (1997): 911-914. http://www.scopus.com/inward/record.url?eid=2-s2.0-0011199483&partnerID=MN8TOARS.
  106. Damour, D.; Dhaleine, F.; Morgat, A.; Vuilhorgne, M.; Mignani, S.. "A convenient synthetic entry into 7-aza-2,2-diphenyl-2-silabicyclo[3.3.0]octane derivatives". Heterocycles 45 9 (1997): 1805-1808. http://www.scopus.com/inward/record.url?eid=2-s2.0-0009856285&partnerID=MN8TOARS.
  107. Boireau, A.; Malgouris, C.; Burgevin, M.-C.; Pény, C.; Durand, G.; Bordier, F.; Meunier, M.; et al. "Neuroprotective effects of RPR 104632, a novel antagonist at the glycine site of the NMDA receptor, in vitro". European Journal of Pharmacology 300 3 (1996): 237-246. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029959010&partnerID=MN8TOARS.
    10.1016/0014-2999(95)00780-6
  108. Heuillet, E.; Petitet, F.; Mignani, S.; Malleron, J.-L.; Lavayre, J.; Néliat, G.; Doble, A.; Blanchard, J.-C.. "The naphthosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor". European Journal of Pharmacology 314 1-2 (1996): 229-233. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030600409&partnerID=MN8TOARS.
    10.1016/S0014-2999(96)00554-7
  109. Damour, D.; Barreau, M.; Blanchard, J.-C.; Burgevin, M.-C.; Doble, A.; Herman, F.; Pantel, G.; et al. "Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/Sandostatin®". Bioorganic and Medicinal Chemistry Letters 6 14 (1996): 1667-1672. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030598673&partnerID=MN8TOARS.
    10.1016/0960-894X(96)00289-2
  110. Damour, D.; Barreau, M.; Dhaleine, F.; Doerflinger, G.; Vuilhorgne, M.; Mignani, S.. "Radical-Induced Cyclizations of 1-Sila-cyclopent-2-ene Derivatives: Synthesis of Novel Azasilabicyclic Compounds". Synlett 1996 9 (1996): 890-892. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242414429&partnerID=MN8TOARS.
    10.1055/s-1996-5586
  111. Mignani, S.; Damour, D.; Bastart, J.-P.; Manuel, G.. "A convenient large scale synthesis of 1,1-diphenyl-1-silacyclopent-3-ene". Synthetic Communications 25 23 (1995): 3855-3861. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028884124&partnerID=MN8TOARS.
    10.1080/00397919508011460
  112. Mignani, S.; Aloup, J.-C.; Barreau, M.; Birraux, G.; Blanchard, J.-C.; Bohme, A.; Boireau, A.; et al. "2H-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxylic acid derivatives, a novel family of glycine antagonists of the NMDA receptor channel complex". Drugs of the Future 20 11 (1995): 1133-1143. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029609959&partnerID=MN8TOARS.
  113. Jimonet, P.; Audiau, F.; Aloup, J.-C.; Barreau, M.; Blanchard, J.-C.; Bohme, A.; Boireau, A.; et al. "Synthesis and sar of 2h-1,2,4-benzothiadiazine-1,1-dioxide-3- carboxylic acid derivatives as novel potent glycine antagonists of the nmda receptor-channel complex". Bioorganic and Medicinal Chemistry Letters 4 23 (1994): 2735-2740. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028090525&partnerID=MN8TOARS.
    10.1016/S0960-894X(01)80586-2
  114. Boukherroub, R.; Manuel, G.; Mignani, S.; Damour, D.. "3,4-Functionalized silacyclopentanes. Synthesis of trans-4-amino-, azido- and alkyloxy-1-silacyclopentan-3-ols from 6-oxa-3-silabicyclo[3.1.0]hexanes". Journal of Organometallic Chemistry 484 1-2 (1994): 119-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-0002678791&partnerID=MN8TOARS.
    10.1016/0022-328X(94)87195-7
  115. Damour, D.; Barreau, M.; Dutruc-Rosset, G.; Doble, A.; Piot, O.; Mignani, S.. "1,1-diphenyl-3-dialkylamino-1-silacyclopentane derivatives: A new class of potent and selective 5-HT2A antagonists". Bioorganic and Medicinal Chemistry Letters 4 3 (1994): 415-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028299769&partnerID=MN8TOARS.
    10.1016/0960-894X(94)80007-3
  116. Damour, D.; Mignani, S.. "A novel and efficient approach to the synthesis of 4-amino-1-sila-cyclopent-2-enes". Synthetic Communications 24 14 (1994): 2017-2027. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028305334&partnerID=MN8TOARS.
    10.1080/00397919408010210
  117. Jimonet, P.; Barreau, M.; Blanchard, J.-C.; Boireau, A.; Doble, A.; Laduron, P.; Lavayre, J.; et al. "Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative". Bioorganic and Medicinal Chemistry 2 8 (1994): 793-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028491754&partnerID=MN8TOARS.
    10.1016/S0968-0896(00)82179-3
  118. Malleron, J.-L.; Guérémy, C.; Mignani, S.; Peyronel, J.-F.; Truchon, A.; Blanchard, J.-C.; Doble, A.; et al. "Additions and Corrections: New Indole Derivatives as Potent and Selective Serotonin Uptake Inhibitors: (J. Med. Chem. (1993) 36(9) (1194–1202) 10.1021/jm00061a010)". Journal of Medicinal Chemistry 36 15 (1993): http://www.scopus.com/inward/record.url?eid=2-s2.0-85022862539&partnerID=MN8TOARS.
    10.1021/jm00067a025
  119. Jimonet, P.; Audiau, F.; Barreau, M.; Mignani, S.. "1,2,4-Thiadiazino[3,4-b]benzothiazole: A new cyclic sulphenimine". Heterocycles 36 12 (1993): 2745-2752. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343789350&partnerID=MN8TOARS.
  120. Malleron, J.-L.; Guérémy, C.; Mignani, S.; Peyronel, J.-F.; Truchon, A.; Blanchard, J.-C.; Doble, A.; et al. "Erratum: New indole derivatives as potent and selective serotonin uptake inhibitors (Journal of Medicinal Chemistry (1993) 36, (1194))". Journal of Medicinal Chemistry 36 15 (1993): http://www.scopus.com/inward/record.url?eid=2-s2.0-0027250668&partnerID=MN8TOARS.
  121. Mignani, S.; Damour, D.; Doble, A.; Labaudinière, R.; Malleron, J.-L.; Piot, O.; Gueremy, C.; et al. "New indole derivatives as potent and selective serotonin uptake inhibitors". Bioorganic and Medicinal Chemistry Letters 3 10 (1993): 1913-1918. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027377366&partnerID=MN8TOARS.
    10.1016/S0960-894X(01)80986-0
  122. Jimonet, P.; Beaudoin, F.; Chevé, M.; Ducrotoy, G.; Dutruc-Rosset, G.; Lurier, D.; Rataud, J.; Stutzmann, J.-M.; Mignani, S.. "Optical isomers of RP 64406: New potent antiglutamate agents". Bioorganic and Medicinal Chemistry Letters 3 6 (1993): 983-988. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027251785&partnerID=MN8TOARS.
    10.1016/S0960-894X(00)80272-3
  123. Mignani, S.; Gueremy, C.; Malleron, J.-L.; Truchon, A.; Peyronel, J.-F.; Bastart, J.-P.. "5,6-Dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinoline-2,2-dioxide: A new N,N'-cyclic sulfamide". Heterocycles 34 5 (1992): 907-910. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750397528&partnerID=MN8TOARS.
  124. Mignani, S.; Audiau, F.; Blevec, J.L.; Nemecek, C.; Barreau, M.; Jimonet, P.; Gueremy, C.. "Versatile methods for the synthesis of 2-amino-6-trifluoromethoxy-(nitro)benzothiazoles". Synthetic Communications 22 19 (1992): 2769-2780. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026805965&partnerID=MN8TOARS.
    10.1080/00397919208021542
  125. Mignani, S.; Damour, D.; Gueremy, C.. "An efficient synthesis of 4, 4-diphenylcyclopentene". Synthetic Communications 20 13 (1990): 1959-1965. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973070069&partnerID=MN8TOARS.
    10.1080/00397919008053126
  126. Trost, B.M.; Seoane, P.; Mignani, S.; Acemoglu, M.. "A Stereocontrolled Cyclopentenone Synthesis via Cycloaddition". Journal of the American Chemical Society 111 19 (1989): 7487-7500. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001199760&partnerID=MN8TOARS.
    10.1021/ja00201a032
  127. Merényi, R.; Janousek, Z.; Viehe, H.G.; Mignani, S.. "Captodative Substituent Effects. - Part 491 ESR Study of Carbon Centered Transient Radicals Using a-Tert.Butylthioacrylonitrile as Radical Trap". Bulletin des Sociétés Chimiques Belges 98 11 (1989): 859-864. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988084564&partnerID=MN8TOARS.
    10.1002/bscb.19890981107
  128. Trost, B.M.; Mignani, S.M.; Nanninga, T.N.. "2- [ (Trimethylsilyl)methyl ]-1 -(trimethylsilyl)propen- 3-yl Carboxylates in Cycloaddition. A Novel Approach for Substitutive Cyclopentannulation". Journal of the American Chemical Society 110 5 (1988): 1602-1608. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001440853&partnerID=MN8TOARS.
    10.1021/ja00213a038
  129. Trost, M.B.; Mignani, S.M.; Nanninga, T.N.. "Carboxylative Trimethylenemethane Cycloadditions Catalyzed by Palladium". Journal of the American Chemical Society 108 19 (1986): 6051-6053. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750829624&partnerID=MN8TOARS.
    10.1021/ja00279a070
  130. Gorissen-Hervens, F.; Mignani, S.; Janousek, Z.; Merényi, R.; Viehe, H.G.. "Model of the trapping of oxygen radicals: trapping of t-butoxy radicals by cd olefins | Modèle de piégeage de radicaux oxygénés: piégeage des radicaux t-butoxy par des oléfines cd.". Archives Internationales de Physiologie et de Biochimie 94 5 (1986): http://www.scopus.com/inward/record.url?eid=2-s2.0-0022836075&partnerID=MN8TOARS.
  131. Trost, B.M.; Mignani, S.. "Tandem Pd-Catalyzed Elimination-Cyclization". Journal of Organic Chemistry 51 18 (1986): 3435-3439. http://www.scopus.com/inward/record.url?eid=2-s2.0-0006203323&partnerID=MN8TOARS.
    10.1021/jo00368a005
  132. Trost, B.M.; Mignani, S.M.. "A stereospecific palladium mediated [3+2] cycloaddition". Tetrahedron Letters 27 35 (1986): 4137-4140. http://www.scopus.com/inward/record.url?eid=2-s2.0-0006155346&partnerID=MN8TOARS.
    10.1016/S0040-4039(00)84930-8
  133. Mignani, S.; Merényi, R.; Janousek, Z.; Viehe, H.G.. "Captodative substituent effects-XV1 1 Part XIV: R. Merényi, A.De Mesmaeker and H.G. Viehe, Tetrahedron Letters 24, 2765 (1983). Generalisation of bridged dehydrodimerisation2 2 Part 2: Part 1: S. Mignani, M. Beaujean, Z. Janousek, R. Merényi and H.G. Viehe, Tetrahedron 37, Suppl. 9, 111 (1981). by varying radicophiles and polarity of attacking radicals". Tetrahedron 41 4 (1985): 769-773. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000856905&partnerID=MN8TOARS.
    10.1016/S0040-4020(01)96455-5
  134. Mignani, S.; Lahousse, F.; Merényi, R.; Janousek, Z.; Viehe, H.G.. "Couplage okydatif facile d'anions substitues captodativement". Tetrahedron Letters 26 38 (1985): 4607-4608. http://www.scopus.com/inward/record.url?eid=2-s2.0-46549098009&partnerID=MN8TOARS.
    10.1016/S0040-4039(00)98764-1
  135. Riga, J.; Verbist, J.J.; Mignani, S.; Janousek, Z.; Merenyi, R.; Viehe, H.G.. "X-ray photoelectron spectroscopic study of captodative olefins: Electronic structure of a-thio-acrylonitrile derivatives". Journal of the Chemical Society, Perkin Transactions 2 7 (1985): 883-885. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049105010&partnerID=MN8TOARS.
    10.1039/P29850000883
  136. Beaujean, M.; Mignani, S.; Merényi, R.; Jancusek, Z.; Viehe, H.G.; Kirch, M.; Lehn, J.M.. "Captodative substituet effects - Part XXII radical dehydrodimerisation and bridged dehydrodimerisation of macrocyclic polyethers". Tetrahedron 40 21 (1984): 4395-4400. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342824703&partnerID=MN8TOARS.
    10.1016/S0040-4020(01)98815-5
  137. Mignani, S.; Merényi, R.; Janousek, Z.; Viehe, H.G.. "Effets de la Substitution Captodative XXX1. Addition Des Radicaux Dérivés de Cétones, D'Aldéhydes et de Formiates À L'a-Tert-Butylthioacrylonitrile2". Bulletin des Sociétés Chimiques Belges 93 11 (1984): 991-998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0004775241&partnerID=MN8TOARS.
    10.1002/bscb.19840931109
  138. Mignani, S.; Janousek, Z.; Merenyi, R.; Viehe, H.G.; Riga, J.; Verbist, J.. "Preparative trapping of tert-butoxy radicals by captodative olefins". Tetrahedron Letters 25 15 (1984): 1571-1574. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000131910&partnerID=MN8TOARS.
    10.1016/S0040-4039(01)90013-9
  139. Mignani, S.; Beaujean, M.; Janousek, Z.; Merenyi, R.; Viehe, H.G.. "Capto-dative substituent effects—VIII: Bridged dehydrodimerisation as a general method of C4-bridging with a-tert captoacrylonitrile synthesis: C4-bridging with a-tert-butylmer-captoacrylonitrile". Tetrahedron 37 (1981): 111-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-0004769352&partnerID=MN8TOARS.
    10.1016/0040-4020(81)85046-6
Livro
  1. Mignani, S.; Patek, M.. 1.10 Chirality and Combinatorial Libraries for Drug Discovery, an Overview. 2012.
    10.1016/B978-0-08-095167-6.00103-8