Filomena Elisabete Lopes Martins Elvas Leitão has been an Associate Professor in the Department of Chemistry and Biochemistry (DQB) at the Faculty of Sciences of the University of Lisbon (FCUL) since April 2023. She graduated in Chemistry in 1984 and obtained her PhD in Physical Chemistry in 1993 at the same institution. She began her academic career at DQB in 1985 as a Trainee Assistant, became Assistant in 1988 after public examination, and was appointed Assistant Professor in 1993. In 1996, she was awarded a NATO postdoctoral fellowship to work in the UK on correlation analysis of biological systems, under the supervision of Professor Michael H. Abraham (UCL) and Dr. Robert Mitchell (SmithKline Beecham). From 1996 to 1998, she served, by invitation, as Director General of the Studies and Planning Office of the Portuguese Secretary of State for Youth. Since 2000, she has been Principal Investigator of the Structure and Reactivity Group, first at the Centro de Química e Bioquímica (CQB) and, since 2019, at the Centro de Química Estrutural (CQE), which is member of the Associate Laboratory, Institute of Molecular Sciences. Since 2025, she is also coordinating CQE’s Physical Chemistry of Hard and Soft Matter Laboratory. She undertook sabbaticals at the University of Barcelona (2001/02, 2008/09) and the University of São Paulo (2016/17), and participated in Erasmus+ teaching and training mobility programmes at Sapienza University in Rome (2015) and the University of Ljubljana (2016). She has been involved in EU COST Actions on medical device infections (2016–2018) and tuberculosis (since 2022), serving on the Management Committee of the latter. Her supervision record includes 4 postdoctoral researchers, 3 PhD theses, 16 Master’s theses (2 ongoing), 6 MSc/BSc research grants, 31 undergraduate final projects, and 12 short-term internships, 9 of which involving foreign students. Her research spans from Physical Chemistry—covering solution kinetics, calorimetry, solute–solvent interactions, QSPR modelling, and solvent engineering—to Medicinal Chemistry, including structure-based drug design, in silico and pre-screening studies, QSAR modelling, and the development of new INH-based antitubercular agents targeting multidrug-resistant tuberculosis. Her key scientific contributions include: (i) the development of preferential solvation models for multicomponent solvent mixtures; (ii) the comparative evaluation of model equations describing solvent effects on reactivity, which led to the proposal of a new equation distinguishing solvent dipolarity from polarizability (developed with her PhD students); and (iii) the design and synthesis of novel INH-based derivatives with enhanced activity against the most prevalente and clinically relevant Mycobacterium tuberculosis KatG mutant strain and reduced cytotoxicity compared to existing drugs. She has been PI in five funded projects (three on tuberculosis), authored over 60 papers, 5 book chapters, and 12 proceedings, and delivered numerous oral and poster presentations. She has also served as referee for over 25 international journals. At DQB, she has held several academic roles, including co-coordination of undergraduate and Master’s program, and co-cordination and coordination of PhD programs, and contributed to Bologna implementation and international accreditations. She has served on multiple committees, including the Board of CQB (2010–2012), the Vice-Presidency of DQB (2015–2018), the Coordination of the CQE PhD Researcher Evaluation Commission (2020–2023), and as member of the CQE Board@Ciências (2022–2023 and 2026–2027). She has also acted as president or member of numerous evaluation panels for PhD researchers (17) and as member of the jury of 2 academic recruitments for assistant professor in Physical Chemistry.