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Alexandra G. Fraga graduated in 2003 in Applied Biology and in 2010 recieved a PhD in Health Sciences from the Univeristy of Minho (UM). Bewteen 2011 and 2019 she developed her postdoctoral studies at the Microbiology and Infection Research Domain at the Life and Health Sciences Research Institute (ICVS), during which she focused on studying the spontaneous healing process of experimental Buruli ulcer, using RNA-Sequencing in animal models of resistance (guinea pigs) and susceptibility (mice) to Mycobacterium ulcerans infection. From 2019 and 2021, she was a junior researcher and her research focused on the identification of the regulatory effects of interindividual genetic variations on molecular and cellular processes of mycobacterial immunity, as well as on the modulation of the host immune response/bacterial activity by using new systems of antimicrobial drug delivery. She is currently continuing this line of research as an Assitant Researcher at the InflammaSignal team at the ICVS. She is recently an Assistant Professor at the School of Medicine, UM. Her track record includes 40 peer-reviewed research articles and 2 book chapters, with an h-index of 19, an accumulated IF of ~200 and over 1500 citations. She has been supported by several funding agencies (e.g., InfectERA, la Caixa Foundation, FCT, ESCMID) and contracts with the industry (e.g., Amicus Therapeutics). She has successfully concluded the supervision of 2 PhD and 5 MSc students. She is the Biosafety Coordinator at the ICVS and is the ICVS representative in the Portuguese Biosafety Laboratory Network, Lab-PTBioNet. She has FELASA Category C accreditation for animal experimentation by the Portuguese National Authority for Animal Health (DGAV) and a vast experience in the mouse and guinea pig model of infection under BSL2 and BSL3 conditions.
Identificação

Identificação pessoal

Nome completo
Alexandra Gabriel Fraga

Nomes de citação

  • Fraga, Alexandra
  • Fraga, Alexandra G.

Identificadores de autor

Ciência ID
7E1F-EDE8-F19D
ORCID iD
0000-0003-2029-1629

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês (Idioma materno)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2011 - 2019
Concluído
Host-pathogen interaction (Pós-doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2010
Concluído
Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
1999 - 2003
Concluído
Applied Biology (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2021 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2021 Investigador Contratado (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2021 - Atual Professor Auxiliar (Docente Universitário) Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2023 - 2025 In vitro screening-based selection and in vivo efficacy evaluation of bacteriophages as potential new assets in the topical treatment of Buruli Ulcer disease.
GSK
Investigador
Universidade do Minho, Portugal
GlaxoSmithKline España
2023/03 - 2024/08 Immunometabolic requirements in Buruli Ulcer
2022.05266.PTDC
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2021 - 2024 A flexible platform for generating synthetic virus to control infectious diseases
La Caixa FITTED - HR21-00533
Investigador
Caixa d'Estalvis i Pensions de Barcelona
Em curso
2021 - 2024 Extracellular Vesicles as Potential Biomarkers in Fabry Disease Progression
Amicus_PL_2021
Investigador
Amicus Therapeutics SLU
Em curso
2020/04/01 - 2022/09/30 Reinforcing the response to COVID-19 pandemic by improving diagnostic tools and capacity (ReCOVMi)
NORTE-01-0145-FEDER-072555
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2020 - 2021 Viral-Based Bioconjugation Platform (ViBBiP) for vaccines development against bacterial pathogens
ESCMID Research Grant 2020
Investigador
European Society of Clinical Microbiology and Infectious Diseases
Concluído
2018 - 2021 lmmunogenetic determinants of susceptibility/resistance to Buruli ulcer: a family- and population-based study for a neglected tropical disease
POCI-01-0145-FEDER-031312
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2016 - 2019 Transcriptome Analysis of Animal Models of Spontaneous Healing of Buruli Ulcer
ERA-NET Infect-ERA (2015) grant BU_SPONT_HEAL
Investigador Pós-doutorado
European Commission
2016 - 2019 Development of a novel colour-coded RING FISH method: an innovative tool for the detection of antibiotic resistant clinical pathogens
241500
PTDC/DTP-PIC/4562/2014
Investigador Pós-doutorado
Fundação para a Ciência e a Tecnologia
Concluído
2016 - 2019 SynPhage: Construction of synthetic phages to combat infectious bacterial diseases
PTDC/BBB-BSS/6471/2014
Investigador Pós-doutorado
Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2012 Buruli ulcer - from understanding the mechanisms of host resistance to the development of new interventions against emerging mycobacterioses
Proc.Nº 94776
Investigador
Fundação Calouste Gulbenkian
Concluído
2006 - 2009 Role of Interleukin-23 (IL-23) and IL-17 in the regulation of the immune response to the infection by Mycobacterium tuberculosis
PTDC/SAU-MII/70895/2006
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2002 - 2005 Impact on public health of difficult-to-treat mycobacterioses: multi-resistant tuberculosis and Buruli ulcer
Proc. Nº 55762
Investigador
Fundação Calouste Gulbenkian
Concluído

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 ICVS/3B's - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 ICVS/3B's - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Coelho-Ribeiro, Bruna; Silva, Helena G.; Sampaio-Marques, Belém; Fraga, Alexandra G.; Azevedo, Olga; Pedrosa, Jorge; Ludovico, Paula. "Inflammation and Exosomes in Fabry Disease Pathogenesis". Cells 13 8 (2024): 654. http://dx.doi.org/10.3390/cells13080654.
    10.3390/cells13080654
  2. Correia, Carla; Leite, Ana Claúdia; Fraga, Alexandra G.; Proença, M. Fernanda; Pedrosa, Jorge; Carvalho, M. Alice. "Discovery of 2,9-diaryl-6-carbamoylpurines as a novel class of antitubercular agents". European Journal of Medicinal Chemistry 268 (2024): 116297. http://dx.doi.org/10.1016/j.ejmech.2024.116297.
    10.1016/j.ejmech.2024.116297
  3. Dominguez, Juan; Mendes, Ana I.; Pacheco, Ana R.; Peixoto, Maria J.; Pedrosa, Jorge; Fraga, Alexandra G.. "Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans". Frontiers in Microbiology 14 (2023): http://dx.doi.org/10.3389/fmicb.2023.1266261.
    10.3389/fmicb.2023.1266261
  4. Costa, Tiago; Veiga, Maria I.; Osório, Nuno S.; Neves, Nuno M.; Aguilar, Helena; Fraga, Alexandra G.. "Development of polyurethane antimicrobial coatings by composition with phenolic-, ionic- and copper-based agents". Journal of Materials Research and Technology 24 (2023): 6942-6957. http://dx.doi.org/10.1016/j.jmrt.2023.04.243.
    10.1016/j.jmrt.2023.04.243
  5. Mendes, Ana Isabel; Fraga, Alexandra G.; Peixoto, Maria João; Aroso, Ivo; Longatto-Filho, Adhemar; Marques, Alexandra Pinto; Pedrosa, Jorge. "Gellan gum spongy-like hydrogel-based dual antibiotic therapy for infected diabetic wounds". Bioengineering & Translational Medicine 8 3 (2023): http://dx.doi.org/10.1002/btm2.10504.
    10.1002/btm2.10504
  6. Geraldes, Inês; Fernandes, Mónica; Fraga, Alexandra G.; Osório, Nuno S.. "The impact of single-cell genomics on the field of mycobacterial infection". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.989464.
    10.3389/fmicb.2022.989464
  7. Mendes, Ana I.; Peixoto, Maria J.; Marques, Alexandra P.; Pedrosa, Jorge; Fraga, Alexandra G.. Autor correspondente: Fraga, Alexandra G.. "An optimized mouse model of Staphylococcus aureus infected diabetic ulcers". BMC Research Notes 15 1 (2022): http://dx.doi.org/10.1186/s13104-022-06170-5.
    10.1186/s13104-022-06170-5
  8. Mendes, Ana I.; Rebelo, Rita; Aroso, Ivo; Correlo, Vitor M.; Fraga, Alexandra G.; Pedrosa, Jorge; Marques, Alexandra P.. "Development of an antibiotics delivery system for topical treatment of the neglected tropical disease Buruli ulcer". International Journal of Pharmaceutics 623 (2022): 121954. http://dx.doi.org/10.1016/j.ijpharm.2022.121954.
    10.1016/j.ijpharm.2022.121954
  9. Fevereiro, João; Fraga, Alexandra G.; Pedrosa, Jorge. "Genetics in the Host-Mycobacterium ulcerans interaction". Immunological Reviews 301 1 (2021): 222-241. http://dx.doi.org/10.1111/imr.12958.
    10.1111/imr.12958
  10. Frias, Jorge; Toubarro, Duarte; Fraga, Alexandra G.; Botelho, Claudia; Teixeira, José; Pedrosa, Jorge; Simões, Nelson. "Purification and Characterization of a Thrombolytic Enzyme Produced by a New Strain ofBacillus subtil". Journal of Microbiology and Biotechnology 31 2 (2021): 327-337. http://dx.doi.org/10.4014/jmb.2008.08010.
    10.4014/jmb.2008.08010
  11. Fevereiro, João; Fraga, Alexandra G.; Capela, Carlos; Sopoh, Ghislain E.; Dossou, Ange; Ayelo, Gilbert Adjimon; Peixoto, Maria João; et al. Autor correspondente: Fraga, Alexandra G.. "Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer". Emerging Microbes & Infections 10 1 (2021): 223-225. http://dx.doi.org/10.1080/22221751.2021.1878936.
    10.1080/22221751.2021.1878936
  12. Fevereiro, João; Sajjadi, Nikta; Fraga, Alexandra G.; Teixeira, Pedro M.; Pedrosa, Jorge. "Individual and clinical variables associated with the risk of Buruli ulcer acquisition: A systematic review and meta-analysis". PLOS Neglected Tropical Diseases 14 4 (2020): e0008161. http://dx.doi.org/10.1371/journal.pntd.0008161.
    10.1371/journal.pntd.0008161
  13. Duarte, D; Fraga, AG.; Pedrosa, J; Martel, F; Vale, N. "Increasing the potential of cell-penetrating peptides for cancer therapy using a new pentagonal scaffold". European Journal of Pharmacology 860 (2019): 172554. https://doi.org/10.1016/j.ejphar.2019.172554.
    10.1016/j.ejphar.2019.172554
  14. Oliveira, Hugo; Mendes, Ana; Fraga, Alexandra G.; Ferreira, Alice; Pimenta, Andreia I.; Mil-Homens, Dalila; Fialho, Arsénio M.; Pedrosa, Jorge; Azeredo, Joana. "K2 Capsule Depolymerase Is Highly Stable, Is Refractory to Resistance, and Protects Larvae and Mice from Acinetobacter baumannii Sepsis". Applied and Environmental Microbiology 85 17 (2019): http://dx.doi.org/10.1128/aem.00934-19.
    10.1128/aem.00934-19
  15. Fraga, Alexandra G.; Trigo, Gabriela; Murthy, Ramya K.; Akhtar, Shamim; Hebbur, Madhavi; Pacheco, Ana Rita; Dominguez, Juan; et al. "Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection". PLOS Neglected Tropical Diseases 13 8 (2019): e0007113. http://dx.doi.org/10.1371/journal.pntd.0007113.
    10.1371/journal.pntd.0007113
  16. Fraga, Alexandra G.; Barbosa, Ana Margarida; Ferreira, Catarina M.; Fevereiro, João; Pedrosa, Jorge; Torrado, Egídio. "Immune-evasion Strategies of Mycobacteria and Their Implications for the Protective Immune Response". Current Issues in Molecular Biology (2018): 169-198. http://dx.doi.org/10.21775/cimb.025.169.
    10.21775/cimb.025.169
  17. De Trizio, Antonella; Srisuk, Pathomthat; Costa, Rui R.; Fraga, Alexandra G.; Modena, Tiziana; Genta, Ida; Dorati, Rossella; et al. "Natural based eumelanin nanoparticles functionalization and preliminary evaluation as carrier for gentamicin". Reactive and Functional Polymers 114 (2017): 38-48. http://dx.doi.org/10.1016/j.reactfunctpolym.2017.03.004.
    10.1016/j.reactfunctpolym.2017.03.004
  18. Vale, Nuno; Correia, Alexandra; Silva, Sara; Figueiredo, Patrícia; Mäkilä, Ermei; Salonen, Jarno; Hirvonen, Jouni; et al. "Preparation and biological evaluation of ethionamide-mesoporous silicon nanoparticles against Mycobacterium tuberculosis". Bioorganic & Medicinal Chemistry Letters 27 3 (2017): 403-405. http://dx.doi.org/10.1016/j.bmcl.2016.12.060.
    10.1016/j.bmcl.2016.12.060
  19. Capela, Carlos; Dossou, Ange Dodji; Silva-Gomes, Rita; Sopoh, Ghislain Emmanuel; Makoutode, Michel; Menino, João Filipe; Fraga, Alexandra G.; et al. "Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer". PLOS Neglected Tropical Diseases 10 4 (2016): e0004671. http://dx.doi.org/10.1371/journal.pntd.0004671.
    10.1371/journal.pntd.0004671
  20. Silva-Gomes, Rita; Marcq, Elly; Trigo, Gabriela; Gonçalves, Carine M.; Longatto-Filho, Adhemar; Castro, António G.; Pedrosa, Jorge; Fraga, Alexandra G.. "Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model". PLOS Neglected Tropical Diseases 9 12 (2015): e0004265. http://dx.doi.org/10.1371/journal.pntd.0004265.
    10.1371/journal.pntd.0004265
  21. Capela, Carlos; Sopoh, Ghislain E.; Houezo, Jean G.; Fiodessihoué, René; Dossou, Ange D.; Costa, Patrício; Fraga, Alexandra G.; et al. "Clinical Epidemiology of Buruli Ulcer from Benin (2005-2013): Effect of Time-Delay to Diagnosis on Clinical Forms and Severe Phenotypes". PLOS Neglected Tropical Diseases 9 9 (2015): e0004005. http://dx.doi.org/10.1371/journal.pntd.0004005.
    10.1371/journal.pntd.0004005
  22. Cruz, Andrea; Torrado, Egídio; Carmona, Jenny; Fraga, Alexandra G.; Costa, Patrício; Rodrigues, Fernando; Appelberg, Rui; et al. "BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells". Vaccine 33 1 (2015): 85-91. http://dx.doi.org/10.1016/j.vaccine.2014.11.013.
    10.1016/j.vaccine.2014.11.013
  23. Gama, José B.; Ohlmeier, Steffen; Martins, Teresa G.; Fraga, Alexandra G.; Sampaio-Marques, Belém; Carvalho, Maria A.; Proença, Fernanda; et al. "Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen". PLoS Neglected Tropical Diseases 8 8 (2014): e3066. http://dx.doi.org/10.1371/journal.pntd.0003066.
    10.1371/journal.pntd.0003066
  24. Trigo, Gabriela; Martins, Teresa G.; Fraga, Alexandra G.; Longatto-Filho, Adhemar; Castro, António G.; Azeredo, Joana; Pedrosa, Jorge. "Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model". PLoS Neglected Tropical Diseases 7 4 (2013): e2183. http://dx.doi.org/10.1371/journal.pntd.0002183.
    10.1371/journal.pntd.0002183
  25. Martins, Teresa G.; Trigo, Gabriela; Fraga, Alexandra G.; Gama, José B.; Longatto-Filho, Adhemar; Saraiva, Margarida; Silva, Manuel T.; Castro, António G.; Pedrosa, Jorge. "Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulcerans Infection". PLoS Neglected Tropical Diseases 6 11 (2012): e1925. http://dx.doi.org/10.1371/journal.pntd.0001925.
    10.1371/journal.pntd.0001925
  26. Fraga, Alexandra G.; Martins, Teresa G.; Torrado, Egídio; Huygen, Kris; Portaels, Françoise; Silva, Manuel T.; Castro, António G.; Pedrosa, Jorge. "Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination". PLoS ONE 7 3 (2012): e33406. http://dx.doi.org/10.1371/journal.pone.0033406.
    10.1371/journal.pone.0033406
  27. Martins, Teresa G.; Gama, José B.; Fraga, Alexandra G.; Saraiva, Margarida; Silva, Manuel T.; Castro, António G.; Pedrosa, Jorge. "Local and Regional Re-Establishment of Cellular Immunity during Curative Antibiotherapy of Murine Mycobacterium ulcerans Infection". PLoS ONE 7 2 (2012): e32740. http://dx.doi.org/10.1371/journal.pone.0032740.
    10.1371/journal.pone.0032740
  28. Fraga, Alexandra G.; Cruz, Andrea; Martins, Teresa G.; Torrado, Egi´dio; Saraiva, Margarida; Pereira, Daniela R.; Meyers, Wayne M.; et al. "Mycobacterium ulcerans Triggers T-Cell Immunity followed by Local and Regional but Not Systemic Immunosuppression". Infection and Immunity 79 1 (2011): 421-430. http://dx.doi.org/10.1128/iai.00820-10.
    10.1128/iai.00820-10
  29. Cruz, Andrea; Fraga, Alexandra G.; Fountain, Jeffrey J.; Rangel-Moreno, Javier; Torrado, Egídio; Saraiva, Margarida; Pereira, Daniela R.; et al. "Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis". Journal of Experimental Medicine 207 8 (2010): 1609-1616. http://dx.doi.org/10.1084/jem.20100265.
    10.1084/jem.20100265
  30. Kibadi, Kapay; Boelaert, Marleen; Fraga, Alexandra G.; Kayinua, Makanzu; Longatto-Filho, Adhemar; Minuku, Jean-Bedel; Mputu-Yamba, Jean-Baptiste; et al. "Response to Treatment in a Prospective Cohort of Patients with Large Ulcerated Lesions Suspected to Be Buruli Ulcer (Mycobacterium ulcerans Disease)". PLoS Neglected Tropical Diseases 4 7 (2010): e736. http://dx.doi.org/10.1371/journal.pntd.0000736.
    10.1371/journal.pntd.0000736
  31. Torrado, Egídio*; Fraga, Alexandra G.*; Logarinho, Elsa; Martins, Teresa G.; Carmona, Jenny A.; Gama, José B.; Carvalho, Maria A.; et al. "IFN-g–Dependent Activation of Macrophages during Experimental Infections by Mycobacterium ulcerans Is Impaired by the Toxin Mycolactone". The Journal of Immunology 184 2 (2009): 947-955*coauthors. http://dx.doi.org/10.4049/jimmunol.0902717.
    10.4049/jimmunol.0902717
  32. Eddyani, Miriam; Fraga, Alexandra G.; Schmitt, Fernando; Uwizeye, Ce´cile; Fissette, Krista; Johnson, Christian; Aguiar, Julia; et al. "Fine-Needle Aspiration, an Efficient Sampling Technique for Bacteriological Diagnosis of Nonulcerative Buruli Ulcer". Journal of Clinical Microbiology 47 6 (2009): 1700-1704. http://dx.doi.org/10.1128/jcm.00197-09.
    10.1128/jcm.00197-09
  33. Kibadi, Kapay; Panda, Mbutu; Tamfum, Jean-Jacques Muyembe; Fraga, Alexandra G.; Filho, Adhemar Longatto; Anyo, Gladys; Pedrosa, Jorge; et al. "New Foci of Buruli Ulcer, Angola and Democratic Republic of Congo". Emerging Infectious Diseases 14 11 (2008): 1790-1792. http://dx.doi.org/10.3201/eid1411.071649.
    10.3201/eid1411.071649
  34. Gaspar, Maria M.; Cruz, Andrea; Fraga, Alexandra G.; Castro, António G.; Cruz, Maria E.M.; Pedrosa, J.. "Developments on Drug Delivery Systems for the Treatment of Mycobacterial Infections". Current Topics in Medicinal Chemistry 8 7 (2008): 579-591. http://dx.doi.org/10.2174/156802608783955629.
    10.2174/156802608783955629
  35. Portaels, Françoise; Meyers, Wayne M.; Ablordey, Anthony; Castro, António G.; Chemlal, Karim; de Rijk, Pim; Elsen, Pierre; et al. "First Cultivation and Characterization of Mycobacterium ulcerans from the Environment". PLoS Neglected Tropical Diseases 2 3 (2008): e178. http://dx.doi.org/10.1371/journal.pntd.0000178.
    10.1371/journal.pntd.0000178
  36. Gaspar, M.M.; Cruz, A.; Penha, A.F.; Reymão, J.; Sousa, A.C.; Eleutério, C.V.; Domingues, S.A.; et al. "Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis". International Journal of Antimicrobial Agents 31 1 (2008): 37-45. http://dx.doi.org/10.1016/j.ijantimicag.2007.08.008.
    10.1016/j.ijantimicag.2007.08.008
  37. Torrado, Egi´dio; Adusumilli, Sarojini; Fraga, Alexandra G.; Small, Pamela L. C.; Castro, Anto´nio G.; Pedrosa, Jorge. "Mycolactone-Mediated Inhibition of Tumor Necrosis Factor Production by Macrophages Infected withMycobacterium ulceransHas Implications for the Control of Infection". Infection and Immunity 75 8 (2007): 3979-3988. http://dx.doi.org/10.1128/iai.00290-07.
    10.1128/iai.00290-07
  38. Torrado, Egi´dio; Fraga, Alexandra G.; Castro, Anto´nio G.; Stragier, Pieter; Meyers, Wayne M.; Portaels, Franc¸oise; Silva, Manuel T.; Pedrosa, Jorge. "Evidence for an Intramacrophage Growth Phase ofMycobacterium ulcerans". Infection and Immunity 75 2 (2007): 977-987. http://dx.doi.org/10.1128/iai.00889-06.
    10.1128/iai.00889-06
  39. Cruz, Andrea; Khader, Shabaana A.; Torrado, Egidio; Fraga, Alexandra G.The Journal of Immunology 177 3 (2006): 1416-1420. http://dx.doi.org/10.4049/jimmunol.177.3.1416.
    10.4049/jimmunol.177.3.1416
  40. Oliveira, Martinha S.*; Fraga, Alexandra G.*; Torrado, Egi´dio; Castro, Anto´nio G.; Pereira, Joa~o P.; Filho, Adhemar Longatto; Milanezi, Fernanda; et al. "Infection withMycobacterium ulceransInduces Persistent Inflammatory Responses in Mice". Infection and Immunity 73 10 (2005): 6299-6310*coauthor. http://dx.doi.org/10.1128/iai.73.10.6299-6310.2005.
    10.1128/iai.73.10.6299-6310.2005
Capítulo de livro
  1. Foulon, Mélanie; Fraga, Alexandra G.; Yeramian, Edouard; Pedrosa, Jorge; Marsollier, Laurent. "Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans". In Biology of Mycobacterial Lipids, 271-290. Elsevier, 2022.
    10.1016/b978-0-323-91948-7.00008-7
  2. Fevereiro, João; Fraga, Alexandra G.; Pedrosa, Jorge. "The Immunology of Buruli Ulcer". 2020.
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019 - 2023 Antimicrobial flexible coating material for the car sharing segment of the automotive industry.
Orientador
Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2017 - 2023 Host genetics of resistance to Mycobacterium ulcerans: bridging clinical and cellular/animal models
Coorientador
Medicine (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2021 - 2022 Single cell genomics in the host/pathogen interaction in Buruli Ulcer
Orientador
Biomedical Engineering (Mestrado)
Universidade do Minho Escola de Engenharia, Portugal
2021 - 2022 Isolation of novel immunogenic protein carriers for vaccine development
Coorientador
2018 - 2019 Sociodemographic and Clinical Variables in the Risk of Buruli Ulcer Development: a Systematic Review and Meta-Analysis
Orientador
Medicine (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
2016 - 2016 Efficacy of a new drug delivery system against Mycobacterium ulcerans infection
Orientador
Bioquímica (Licenciatura/Bacharelato)
Universidade do Minho, Portugal
2016 - 2016 Effect of corticosteroid-immunosuppression in guinea pig infected with Mycobacterium ulcerans
Orientador
Bioquímica (Licenciatura/Bacharelato)
Universidade do Minho, Portugal
2013 - 2014 The impact of immune gene polymorphisms in human Mycobacterium ulcerans infection
Orientador
Ciências da Saúde (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013 - 2014 Characterization of the innate and acquired immune responses in the guinea pig during infection with Mycobacterium ulcerans
Coorientador
Biomedical Sciences (Mestrado)
Universiteit Antwerpen, Bélgica
2012 - 2012 Buruli Ulcer: Comparative analysis of the murine and guinea pig model during infection with Mycobacterium ulcerans
Orientador
Bioquímica (Licenciatura/Bacharelato)
Universidade do Minho, Portugal
2011 - 2012 Study of the bactericidal activity of Elagic Acid against Mycobacterium tuberculosis
Orientador
Medicina (Mestrado)
Universidade do Minho Escola de Medicina, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2023 Innate regulation of antifungal immunity in chronic pulmonary aspergillosis
Arguente
Cláudio Oliveira (Doutoramento)
2022 Metabolic regulation of antifungal immunity: from basic mechanisms to clinical translation
Arguente
Samuel Gonçalves (Doutoramento)
2022 Isolation and Characterization of extracellular vesicles from acute myeloid and bone marrow stromal cells
Arguente
Mafalda Barros (Mestrado)
2022 Impact of food supplements on yeast chronological aging
Arguente
Sara Dourado (Mestrado)
2021/07 Immunometabolic crosstalk between host and pathogen: unveiling novel therapeutic approaches for visceral leishmaniasis
Arguente
Carolina Alves Ferreira (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2020/12 Crosslinking Immunity and Metabolism during Leishmania Infection
Arguente
Inês Morais Mesquita (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2020/10 Thymic infection and T cell immunodominance during Mycobacterium avium infection
Arguente
Bruno Miguel Cerqueira Rodrigues (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2016/11 Immunogenetic determinants of susceptibility/resistance to Mycobacterium ulcerans infection: a population based study - Benin biological bank on Buruli ulcer
Arguente
Carlos Alberto Pereira Capela (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2012 - Atual Member of Lab-PTBioNet: ICVS, UMinho representative: The Portuguese Biosafety Laboratory Network, Lab-PTBioNet, has the mission to pomote a Biosafety laboratory policy and implement good Biosafety practices in all biological safety level 3 (BSL-3) laboratories in Portugal.
Membro
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2012 - Atual ICVS Biosafety Coordinator for BSL2/3: engaged in the implementation and dissemination of institutional and personal preventive measures to promote the safe handling of biological agents and reduce the risk of individual exposure and avoid the risk of intentional removal or misuse of a biological agent with the intention of causing harm.
Coordenador
2020 - 2021 ICVS member of the COVID-19 diagnostic team: team leader of the inactivation station for COVID-19 diagnostics
Membro
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2021 Member of the Technical Committee: member of CT207 for the translation of ISO 35001:2021 - Biorisk management for laboratories and other related organisations
Membro
Distinções

Prémio

2019 Best Poster Award at Microbiotec19 for the work: Statins as new candidates for the treatment of Buruli Ulcer
2010 Pulido Valente Ciência Award with the work: Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis J. Exp. Med., 2010; 207(8): 1609-16
2010 Best Paper Award from the Portuguese Society for Immunology, with the work: Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J. Exp. Med., 2010; 207(8): 1609-16
2006 Excellence Award in Immunology Mário Arala Chaves at the Portuguese Society for Immunology, with the work: Th17 cells inducing a massive recruitment of neutrophils may play a role in Koch reaction.