Alexandra Gabriel Fraga (7E1F-EDE8-F19D)

Curriculum Vitae

Alexandra Gabriel Fraga

Alexandra G. Fraga graduated in Applied Biology in 2003 and obtained her PhD in Health Sciences from the University of Minho (UM) in 2010. Between 2011 and 2019, she conducted postdoctoral research at the Life and Health Sciences Research Institute (ICVS), investigating the mechanisms underlying spontaneous healing in experimental Buruli ulcer using RNA-sequencing approaches in animal models of resistance (guinea pigs) and susceptibility (mice) to Mycobacterium ulcerans infection. From 2019 to 2021, she was a Junior Researcher at ICVS, studying the regulatory effects of interindividual genetic variation on molecular and cellular mechanisms of antimycobacterial immunity. Over the years, her work has increasingly focused on translating mechanistic insights from host–pathogen interactions into novel therapeutic solutionsfor infectious diseases,, including antimicrobial compounds, advanced drug-delivery systems, and phage-based therapies, bridging fundamental discoveries with potential clinical applications. AG Fraga is currently an Assistant Researcher in the InflammaSignal team at the ICVS and an Assistant Professor at the School of Medicine-UM. AG Fraga has authored 42 peer-reviewed publications and 2 book chapters, with an h-index of 21, over 1,800 citations, and a cumulative impact factor exceeding 200. She has secured competitive funding from national and international agencies, including Infect-ERA, the “la Caixa” Foundation, FCT, and ESCMID, as well as research contracts with industry partners such as Amicus Therapeutics and GSK-OpenLabTresCantos Foundation. AG Fraga has extensive experience in research training and supervision, having successfully supervised 2 PhD and 8 MSc students, and currently supervises 3 PhD students. In addition to her research activities, she contributes to institutional governance and research infrastructure. She serves as Biosafety Level 3 Coordinator at the ICVS and represents the institute in the Portuguese Biosafety Laboratory Network (Lab-PTBioNet). AG Fraga holds FELASA Category C certification for animal experimentation, accredited by the Portuguese National Authority for Animal Health (DGAV).

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Identificação

Identificação pessoal

Nome completo: Alexandra Gabriel Fraga

Nomes de citação

Fraga, Alexandra
Fraga, Alexandra G.

Identificadores de autor

Ciência ID: 7E1F-EDE8-F19D
ORCID iD: 0000-0003-2029-1629

Domínios de atuação

Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês (Idioma materno)
Português	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)

Formação

	Grau	Classificação
2011 - 2019 Concluído	Host-pathogen interaction (Pós-doutoramento) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2010 Concluído	Health Sciences (Doutoramento) Universidade do Minho Escola de Medicina, Portugal
1999 - 2003 Concluído	Applied Biology (Licenciatura) Universidade do Minho Escola de Ciências, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2021 - Atual	Investigador Auxiliar (carreira) (Investigação)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2021	Investigador Contratado (Investigação)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2021 - Atual	Professor Auxiliar (Docente Universitário)	Universidade do Minho Escola de Medicina, Portugal
	Universidade do Minho Escola de Medicina, Portugal

Projetos

Bolsa

	Designação	Financiadores
2023 - 2026	In vitro screening-based selection and in vivo efficacy evaluation of bacteriophages as potential new assets in the topical treatment of Buruli Ulcer disease. TC309 Investigador Universidade do Minho, Portugal	GlaxoSmithKline España Tres Cantos Open Lab Foundation
2024/03/11 - 2024/12/31	ICVS/3B's - Associate Laboratory UIDB/50026/2020 10.54499/UIDB/50026/2020 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2023/03 - 2024/08	Immunometabolic requirements in Buruli Ulcer 2022.05266.PTDC Investigador responsável	Fundação para a Ciência e a Tecnologia Concluído
2021 - 2024	A flexible platform for generating synthetic virus to control infectious diseases La Caixa FITTED - HR21-00533 Investigador	Caixa d'Estalvis i Pensions de Barcelona Concluído
2021 - 2024	Extracellular Vesicles as Potential Biomarkers in Fabry Disease Progression Amicus_PL_2021 Investigador	Amicus Therapeutics SLU Concluído
2020/04/01 - 2022/09/30	Reinforcing the response to COVID-19 pandemic by improving diagnostic tools and capacity (ReCOVMi) NORTE-01-0145-FEDER-072555 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2020 - 2021	Viral-Based Bioconjugation Platform (ViBBiP) for vaccines development against bacterial pathogens ESCMID Research Grant 2020 Investigador	European Society of Clinical Microbiology and Infectious Diseases Concluído
2018 - 2021	lmmunogenetic determinants of susceptibility/resistance to Buruli ulcer: a family- and population-based study for a neglected tropical disease POCI-01-0145-FEDER-031312 Investigador responsável	Fundação para a Ciência e a Tecnologia Concluído
2016 - 2019	Transcriptome Analysis of Animal Models of Spontaneous Healing of Buruli Ulcer ERA-NET Infect-ERA (2015) grant BU_SPONT_HEAL Investigador Pós-doutorado	European Commission Concluído
2016 - 2019	Development of a novel colour-coded RING FISH method: an innovative tool for the detection of antibiotic resistant clinical pathogens 241500 PTDC/DTP-PIC/4562/2014 Investigador Pós-doutorado	Fundação para a Ciência e a Tecnologia Concluído
2016 - 2019	SynPhage: Construction of synthetic phages to combat infectious bacterial diseases PTDC/BBB-BSS/6471/2014 Investigador Pós-doutorado	Fundação para a Ciência e a Tecnologia Concluído
2009 - 2012	Buruli ulcer - from understanding the mechanisms of host resistance to the development of new interventions against emerging mycobacterioses Proc.Nº 94776 Investigador	Fundação Calouste Gulbenkian Concluído
2006 - 2009	Role of Interleukin-23 (IL-23) and IL-17 in the regulation of the immune response to the infection by Mycobacterium tuberculosis PTDC/SAU-MII/70895/2006 Investigador Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2002 - 2005	Impact on public health of difficult-to-treat mycobacterioses: multi-resistant tuberculosis and Buruli ulcer Proc. Nº 55762 Investigador	Fundação Calouste Gulbenkian Concluído

Projeto

	Designação	Financiadores
2021/01/01 - 2025/12/31	ICVS/3B's - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos LA/P/0050/2020 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2019/01/01 - 2019/12/31	ICVS/3B's - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group UID/Multi/50026/2019 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/01/01 - 2014/12/31	Strategic Project - LA 26 - 2013-2014 PEst-C/SAU/LA0026/2013 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista

Foulon, Mélanie*; Fraga, Alexandra G.*; Robbe-Saule, Marie*; Tarnaud, François; Lafont, Marion; Lebon, Guillaume; Fevereiro, João; et al. "The orphan receptor GPR84 drives inflammation in Buruli ulcer development.". Science Translational Medicine (2026):
Aceite para publicação
Costa, Tiago; Sampaio-Marques, Belém; Neves, Nuno M.; Aguilar, Helena; Fraga, Alexandra G.. "Antimicrobial properties of hindered amine light stabilizers in polymer coating materials and their mechanism of action". Frontiers in Bioengineering and Biotechnology 12 (2024): http://dx.doi.org/10.3389/fbioe.2024.1390513.
10.3389/fbioe.2024.1390513
Coelho-Ribeiro, Bruna; Silva, Helena G.; Sampaio-Marques, Belém; Fraga, Alexandra G.; Azevedo, Olga; Pedrosa, Jorge; Ludovico, Paula. "Inflammation and Exosomes in Fabry Disease Pathogenesis". Cells 13 8 (2024): 654. http://dx.doi.org/10.3390/cells13080654.
10.3390/cells13080654
Correia, Carla; Leite, Ana Claúdia; Fraga, Alexandra G.; Proença, M. Fernanda; Pedrosa, Jorge; Carvalho, M. Alice. "Discovery of 2,9-diaryl-6-carbamoylpurines as a novel class of antitubercular agents". European Journal of Medicinal Chemistry 268 (2024): 116297. http://dx.doi.org/10.1016/j.ejmech.2024.116297.
10.1016/j.ejmech.2024.116297
Dominguez, Juan; Mendes, Ana I.; Pacheco, Ana R.; Peixoto, Maria J.; Pedrosa, Jorge; Fraga, Alexandra G.. "Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans". Frontiers in Microbiology 14 (2023): http://dx.doi.org/10.3389/fmicb.2023.1266261.
10.3389/fmicb.2023.1266261
Costa, Tiago; Veiga, Maria I.; Osório, Nuno S.; Neves, Nuno M.; Aguilar, Helena; Fraga, Alexandra G.. "Development of polyurethane antimicrobial coatings by composition with phenolic-, ionic- and copper-based agents". Journal of Materials Research and Technology 24 (2023): 6942-6957. http://dx.doi.org/10.1016/j.jmrt.2023.04.243.
10.1016/j.jmrt.2023.04.243
Mendes, Ana Isabel; Fraga, Alexandra G.; Peixoto, Maria João; Aroso, Ivo; Longatto-Filho, Adhemar; Marques, Alexandra Pinto; Pedrosa, Jorge. "Gellan gum spongy-like hydrogel-based dual antibiotic therapy for infected diabetic wounds". Bioengineering & Translational Medicine 8 3 (2023): http://dx.doi.org/10.1002/btm2.10504.
10.1002/btm2.10504
Geraldes, Inês; Fernandes, Mónica; Fraga, Alexandra G.; Osório, Nuno S.. "The impact of single-cell genomics on the field of mycobacterial infection". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.989464.
10.3389/fmicb.2022.989464
Mendes, Ana I.; Peixoto, Maria J.; Marques, Alexandra P.; Pedrosa, Jorge; Fraga, Alexandra G.. Autor correspondente: Fraga, Alexandra G.. "An optimized mouse model of Staphylococcus aureus infected diabetic ulcers". BMC Research Notes 15 1 (2022): http://dx.doi.org/10.1186/s13104-022-06170-5.
10.1186/s13104-022-06170-5
Mendes, Ana I.; Rebelo, Rita; Aroso, Ivo; Correlo, Vitor M.; Fraga, Alexandra G.; Pedrosa, Jorge; Marques, Alexandra P.. "Development of an antibiotics delivery system for topical treatment of the neglected tropical disease Buruli ulcer". International Journal of Pharmaceutics 623 (2022): 121954. http://dx.doi.org/10.1016/j.ijpharm.2022.121954.
10.1016/j.ijpharm.2022.121954
Fevereiro, João; Fraga, Alexandra G.; Pedrosa, Jorge. "Genetics in the Host-Mycobacterium ulcerans interaction". Immunological Reviews 301 1 (2021): 222-241. http://dx.doi.org/10.1111/imr.12958.
10.1111/imr.12958
Frias, Jorge; Toubarro, Duarte; Fraga, Alexandra G.; Botelho, Claudia; Teixeira, José; Pedrosa, Jorge; Simões, Nelson. "Purification and Characterization of a Thrombolytic Enzyme Produced by a New Strain ofBacillus subtil". Journal of Microbiology and Biotechnology 31 2 (2021): 327-337. http://dx.doi.org/10.4014/jmb.2008.08010.
10.4014/jmb.2008.08010
Fevereiro, João; Fraga, Alexandra G.; Capela, Carlos; Sopoh, Ghislain E.; Dossou, Ange; Ayelo, Gilbert Adjimon; Peixoto, Maria João; et al. Autor correspondente: Fraga, Alexandra G.. "Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer". Emerging Microbes & Infections 10 1 (2021): 223-225. http://dx.doi.org/10.1080/22221751.2021.1878936.
10.1080/22221751.2021.1878936
Fevereiro, João; Sajjadi, Nikta; Fraga, Alexandra G.; Teixeira, Pedro M.; Pedrosa, Jorge. "Individual and clinical variables associated with the risk of Buruli ulcer acquisition: A systematic review and meta-analysis". PLOS Neglected Tropical Diseases 14 4 (2020): e0008161. http://dx.doi.org/10.1371/journal.pntd.0008161.
10.1371/journal.pntd.0008161
Duarte, D; Fraga, AG.; Pedrosa, J; Martel, F; Vale, N. "Increasing the potential of cell-penetrating peptides for cancer therapy using a new pentagonal scaffold". European Journal of Pharmacology 860 (2019): 172554. https://doi.org/10.1016/j.ejphar.2019.172554.
10.1016/j.ejphar.2019.172554
Oliveira, Hugo; Mendes, Ana; Fraga, Alexandra G.; Ferreira, Alice; Pimenta, Andreia I.; Mil-Homens, Dalila; Fialho, Arsénio M.; Pedrosa, Jorge; Azeredo, Joana. "K2 Capsule Depolymerase Is Highly Stable, Is Refractory to Resistance, and Protects Larvae and Mice from Acinetobacter baumannii Sepsis". Applied and Environmental Microbiology 85 17 (2019): http://dx.doi.org/10.1128/aem.00934-19.
10.1128/aem.00934-19
Fraga, Alexandra G.; Trigo, Gabriela; Murthy, Ramya K.; Akhtar, Shamim; Hebbur, Madhavi; Pacheco, Ana Rita; Dominguez, Juan; et al. "Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection". PLOS Neglected Tropical Diseases 13 8 (2019): e0007113. http://dx.doi.org/10.1371/journal.pntd.0007113.
10.1371/journal.pntd.0007113
Fraga, Alexandra G.; Barbosa, Ana Margarida; Ferreira, Catarina M.; Fevereiro, João; Pedrosa, Jorge; Torrado, Egídio. "Immune-evasion Strategies of Mycobacteria and Their Implications for the Protective Immune Response". Current Issues in Molecular Biology (2018): 169-198. http://dx.doi.org/10.21775/cimb.025.169.
10.21775/cimb.025.169
De Trizio, Antonella; Srisuk, Pathomthat; Costa, Rui R.; Fraga, Alexandra G.; Modena, Tiziana; Genta, Ida; Dorati, Rossella; et al. "Natural based eumelanin nanoparticles functionalization and preliminary evaluation as carrier for gentamicin". Reactive and Functional Polymers 114 (2017): 38-48. http://dx.doi.org/10.1016/j.reactfunctpolym.2017.03.004.
10.1016/j.reactfunctpolym.2017.03.004
Vale, Nuno; Correia, Alexandra; Silva, Sara; Figueiredo, Patrícia; Mäkilä, Ermei; Salonen, Jarno; Hirvonen, Jouni; et al. "Preparation and biological evaluation of ethionamide-mesoporous silicon nanoparticles against Mycobacterium tuberculosis". Bioorganic & Medicinal Chemistry Letters 27 3 (2017): 403-405. http://dx.doi.org/10.1016/j.bmcl.2016.12.060.
10.1016/j.bmcl.2016.12.060
Capela, Carlos; Dossou, Ange Dodji; Silva-Gomes, Rita; Sopoh, Ghislain Emmanuel; Makoutode, Michel; Menino, João Filipe; Fraga, Alexandra G.; et al. "Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer". PLOS Neglected Tropical Diseases 10 4 (2016): e0004671. http://dx.doi.org/10.1371/journal.pntd.0004671.
10.1371/journal.pntd.0004671
Silva-Gomes, Rita; Marcq, Elly; Trigo, Gabriela; Gonçalves, Carine M.; Longatto-Filho, Adhemar; Castro, António G.; Pedrosa, Jorge; Fraga, Alexandra G.. "Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model". PLOS Neglected Tropical Diseases 9 12 (2015): e0004265. http://dx.doi.org/10.1371/journal.pntd.0004265.
10.1371/journal.pntd.0004265
Capela, Carlos; Sopoh, Ghislain E.; Houezo, Jean G.; Fiodessihoué, René; Dossou, Ange D.; Costa, Patrício; Fraga, Alexandra G.; et al. "Clinical Epidemiology of Buruli Ulcer from Benin (2005-2013): Effect of Time-Delay to Diagnosis on Clinical Forms and Severe Phenotypes". PLOS Neglected Tropical Diseases 9 9 (2015): e0004005. http://dx.doi.org/10.1371/journal.pntd.0004005.
10.1371/journal.pntd.0004005
Cruz, Andrea; Torrado, Egídio; Carmona, Jenny; Fraga, Alexandra G.; Costa, Patrício; Rodrigues, Fernando; Appelberg, Rui; et al. "BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells". Vaccine 33 1 (2015): 85-91. http://dx.doi.org/10.1016/j.vaccine.2014.11.013.
10.1016/j.vaccine.2014.11.013
Gama, José B.; Ohlmeier, Steffen; Martins, Teresa G.; Fraga, Alexandra G.; Sampaio-Marques, Belém; Carvalho, Maria A.; Proença, Fernanda; et al. "Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen". PLoS Neglected Tropical Diseases 8 8 (2014): e3066. http://dx.doi.org/10.1371/journal.pntd.0003066.
10.1371/journal.pntd.0003066
Trigo, Gabriela; Martins, Teresa G.; Fraga, Alexandra G.; Longatto-Filho, Adhemar; Castro, António G.; Azeredo, Joana; Pedrosa, Jorge. "Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model". PLoS Neglected Tropical Diseases 7 4 (2013): e2183. http://dx.doi.org/10.1371/journal.pntd.0002183.
10.1371/journal.pntd.0002183
Martins, Teresa G.; Trigo, Gabriela; Fraga, Alexandra G.; Gama, José B.; Longatto-Filho, Adhemar; Saraiva, Margarida; Silva, Manuel T.; Castro, António G.; Pedrosa, Jorge. "Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulcerans Infection". PLoS Neglected Tropical Diseases 6 11 (2012): e1925. http://dx.doi.org/10.1371/journal.pntd.0001925.
10.1371/journal.pntd.0001925
Fraga, Alexandra G.; Martins, Teresa G.; Torrado, Egídio; Huygen, Kris; Portaels, Françoise; Silva, Manuel T.; Castro, António G.; Pedrosa, Jorge. "Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination". PLoS ONE 7 3 (2012): e33406. http://dx.doi.org/10.1371/journal.pone.0033406.
10.1371/journal.pone.0033406
Martins, Teresa G.; Gama, José B.; Fraga, Alexandra G.; Saraiva, Margarida; Silva, Manuel T.; Castro, António G.; Pedrosa, Jorge. "Local and Regional Re-Establishment of Cellular Immunity during Curative Antibiotherapy of Murine Mycobacterium ulcerans Infection". PLoS ONE 7 2 (2012): e32740. http://dx.doi.org/10.1371/journal.pone.0032740.
10.1371/journal.pone.0032740
Fraga, Alexandra G.; Cruz, Andrea; Martins, Teresa G.; Torrado, Egi´dio; Saraiva, Margarida; Pereira, Daniela R.; Meyers, Wayne M.; et al. "Mycobacterium ulcerans Triggers T-Cell Immunity followed by Local and Regional but Not Systemic Immunosuppression". Infection and Immunity 79 1 (2011): 421-430. http://dx.doi.org/10.1128/iai.00820-10.
10.1128/iai.00820-10
Cruz, Andrea; Fraga, Alexandra G.; Fountain, Jeffrey J.; Rangel-Moreno, Javier; Torrado, Egídio; Saraiva, Margarida; Pereira, Daniela R.; et al. "Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis". Journal of Experimental Medicine 207 8 (2010): 1609-1616. http://dx.doi.org/10.1084/jem.20100265.
10.1084/jem.20100265
Kibadi, Kapay; Boelaert, Marleen; Fraga, Alexandra G.; Kayinua, Makanzu; Longatto-Filho, Adhemar; Minuku, Jean-Bedel; Mputu-Yamba, Jean-Baptiste; et al. "Response to Treatment in a Prospective Cohort of Patients with Large Ulcerated Lesions Suspected to Be Buruli Ulcer (Mycobacterium ulcerans Disease)". PLoS Neglected Tropical Diseases 4 7 (2010): e736. http://dx.doi.org/10.1371/journal.pntd.0000736.
10.1371/journal.pntd.0000736
Torrado, Egídio*; Fraga, Alexandra G.*; Logarinho, Elsa; Martins, Teresa G.; Carmona, Jenny A.; Gama, José B.; Carvalho, Maria A.; et al. "IFN-g–Dependent Activation of Macrophages during Experimental Infections by Mycobacterium ulcerans Is Impaired by the Toxin Mycolactone". The Journal of Immunology 184 2 (2009): 947-955*coauthors. http://dx.doi.org/10.4049/jimmunol.0902717.
10.4049/jimmunol.0902717
Eddyani, Miriam; Fraga, Alexandra G.; Schmitt, Fernando; Uwizeye, Ce´cile; Fissette, Krista; Johnson, Christian; Aguiar, Julia; et al. "Fine-Needle Aspiration, an Efficient Sampling Technique for Bacteriological Diagnosis of Nonulcerative Buruli Ulcer". Journal of Clinical Microbiology 47 6 (2009): 1700-1704. http://dx.doi.org/10.1128/jcm.00197-09.
10.1128/jcm.00197-09
Kibadi, Kapay; Panda, Mbutu; Tamfum, Jean-Jacques Muyembe; Fraga, Alexandra G.; Filho, Adhemar Longatto; Anyo, Gladys; Pedrosa, Jorge; et al. "New Foci of Buruli Ulcer, Angola and Democratic Republic of Congo". Emerging Infectious Diseases 14 11 (2008): 1790-1792. http://dx.doi.org/10.3201/eid1411.071649.
10.3201/eid1411.071649
Gaspar, Maria M.; Cruz, Andrea; Fraga, Alexandra G.; Castro, António G.; Cruz, Maria E.M.; Pedrosa, J.. "Developments on Drug Delivery Systems for the Treatment of Mycobacterial Infections". Current Topics in Medicinal Chemistry 8 7 (2008): 579-591. http://dx.doi.org/10.2174/156802608783955629.
10.2174/156802608783955629
Portaels, Françoise; Meyers, Wayne M.; Ablordey, Anthony; Castro, António G.; Chemlal, Karim; de Rijk, Pim; Elsen, Pierre; et al. "First Cultivation and Characterization of Mycobacterium ulcerans from the Environment". PLoS Neglected Tropical Diseases 2 3 (2008): e178. http://dx.doi.org/10.1371/journal.pntd.0000178.
10.1371/journal.pntd.0000178
Gaspar, Maria M.; Cruz, Andrea; Penha, Ana Filipa; Reymão, João; Sousa, Ana Cristina; Eleutério, Carla V.; Domingues, Sofia A.; et al. "Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis". International Journal of Antimicrobial Agents 31 1 (2008): 37-45. http://dx.doi.org/10.1016/j.ijantimicag.2007.08.008.
10.1016/j.ijantimicag.2007.08.008
Torrado, Egidio; Adusumilli, Sarojini; Fraga, Alexandra G.; Small, Pamela L. C.; Castro, Antonio G.; Pedrosa, Jorge. "Mycolactone-Mediated Inhibition of Tumor Necrosis Factor Production by Macrophages Infected withMycobacterium ulceransHas Implications for the Control of Infection". Infection and Immunity 75 8 (2007): 3979-3988. http://dx.doi.org/10.1128/iai.00290-07.
10.1128/iai.00290-07
Torrado, Egidio; Fraga, Alexandra G.; Castro, Antonio G.; Stragier, Pieter; Meyers, Wayne M.; Portaels, Francoise; Silva, Manuel T.; Pedrosa, Jorge. "Evidence for an Intramacrophage Growth Phase ofMycobacterium ulcerans". Infection and Immunity 75 2 (2007): 977-987. http://dx.doi.org/10.1128/iai.00889-06.
10.1128/iai.00889-06
Cruz, Andrea; Khader, Shabana A.; Torrado, Egidio; Fraga, Alexandra G.; Pearl, John E.; Pedrosa, Jorge; Cooper, Andrea M.; Castro, Antonio G.. "Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection". Journal of Immunology 177 3 (2006): 1416-1420. https://doi.org/10.4049/jimmunol.177.3.1416.
Oliveira, Martinha S.*; Fraga, Alexandra G.*; Torrado, Egidio; Castro, Antonio G.; Pereira, Joao P.; Filho, Adhemar Longatto; Milanezi, Fernanda; et al. "Infection with Mycobacterium ulcerans Induces Persistent Inflammatory Responses in Mice". Infection and Immunity 73 10 (2005): 6299-6310*coauthor. http://dx.doi.org/10.1128/iai.73.10.6299-6310.2005.
10.1128/iai.73.10.6299-6310.2005

Capítulo de livro

Foulon, Mélanie; Fraga, Alexandra G.; Yeramian, Edouard; Pedrosa, Jorge; Marsollier, Laurent. "Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans". In Biology of Mycobacterial Lipids, 271-290. Elsevier, 2022.
10.1016/b978-0-323-91948-7.00008-7
Fevereiro, João; Fraga, Alexandra G.; Pedrosa, Jorge. "The Immunology of Buruli Ulcer". 2020.

Atividades

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2025 - 2030	Ferroptosis-mediated cell death in Mycobacterium ulcerans Infection: insights into Buruli ulcer pathogenesis Orientador	Universidade do Minho Escola de Medicina, Portugal
2025 - 2029	3D writing of advanced multicellular tendon-on-chip models to unlock the (patho)physiological signatures of tendon tissues Coorientador	Universidade do Minho Escola de Medicina, Portugal
2025 - 2029	Engineered, tailored bacteriophage cocktails for improved control of Klebsiella pneumoniae infections Coorientador	Universidade do Minho Escola de Ciências, Portugal
2025 - 2026	Assessing the Potential of Combined Antibiotic–Bacteriophage Therapy Against Mycobacterium ulcerans Infections Orientador	Biomedicine (Mestrado)
2024 - 2024	Immunometabolic Requirements in Buruli Ulcer Orientador	Medicine (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2019 - 2023	Antimicrobial flexible coating material for the car sharing segment of the automotive industry. Orientador	Health Sciences (Doutoramento) Universidade do Minho Escola de Medicina, Portugal
2017 - 2023	Host genetics of resistance to Mycobacterium ulcerans: bridging clinical and cellular/animal models Coorientador	Medicine (Doutoramento) Universidade do Minho Escola de Medicina, Portugal
2021 - 2022	Single cell genomics in the host/pathogen interaction in Buruli Ulcer Orientador	Biomedical Engineering (Mestrado) Universidade do Minho Escola de Engenharia, Portugal
2021 - 2022	Isolation of novel immunogenic protein carriers for vaccine development Coorientador	Biotechnology (Mestrado) Universidade do Minho Escola de Ciências, Portugal
2018 - 2019	Sociodemographic and Clinical Variables in the Risk of Buruli Ulcer Development: a Systematic Review and Meta-Analysis Orientador	Medicine (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2016 - 2016	Efficacy of a new drug delivery system against Mycobacterium ulcerans infection Orientador	Biochemistry (Licenciatura/Bacharelato) Universidade do Minho, Portugal
2016 - 2016	Effect of corticosteroid-immunosuppression in guinea pig infected with Mycobacterium ulcerans Orientador	Biochemistry (Licenciatura/Bacharelato) Universidade do Minho, Portugal
2013 - 2014	The impact of immune gene polymorphisms in human Mycobacterium ulcerans infection Orientador	Health Sciences (Mestrado) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013 - 2014	Characterization of the innate and acquired immune responses in the guinea pig during infection with Mycobacterium ulcerans Coorientador	Biomedical Sciences (Mestrado) Universiteit Antwerpen, Bélgica
2012 - 2012	Buruli Ulcer: Comparative analysis of the murine and guinea pig model during infection with Mycobacterium ulcerans Orientador	Biochemistry (Licenciatura/Bacharelato) Universidade do Minho, Portugal
2011 - 2012	Study of the bactericidal activity of Elagic Acid against Mycobacterium tuberculosis Orientador	Medicine (Mestrado) Universidade do Minho Escola de Medicina, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2026	Lipid metabolism-mediated mechanism of antifungal immunity Arguente	Maria Adriana Gomes Teixeira da Costa (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2025/02	The Role of c-MET Signaling Pathway in Regulation of Antifungal Immunity Arguente principal	Ana Beatriz Oliveira Machado (Mestrado) Universidade de Trás-os-Montes e Alto Douro, Portugal
2025	Characterization of genetic diversity of Plasmodium spp in Dominican Republic Arguente	Claudia Alejandra Cabrera Federo (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2025	Phage Therapy applied to Chronic Lung Infections: development and monitoring of therapeutic protocols Arguente principal	Sara Isabel Muga Vieira (Mestrado) Universidade do Minho Escola de Ciências, Portugal
2024/10	Isolation of polyvalent bacteriophages against drug-resistant bacterial pathogens Arguente principal	Sophia Lorenz (Mestrado) Universidade do Minho, Portugal
2023	Innate regulation of antifungal immunity in chronic pulmonary aspergillosis Arguente	Cláudio Oliveira (Doutoramento)
2022	Metabolic regulation of antifungal immunity: from basic mechanisms to clinical translation Arguente	Samuel Gonçalves (Doutoramento)
2022	Isolation and Characterization of extracellular vesicles from acute myeloid and bone marrow stromal cells Arguente	Mafalda Barros (Mestrado)
2022	Impact of food supplements on yeast chronological aging Arguente	Sara Dourado (Mestrado)
2021/07	Immunometabolic crosstalk between host and pathogen: unveiling novel therapeutic approaches for visceral leishmaniasis Arguente	Carolina Alves Ferreira (Doutoramento) Universidade do Minho Escola de Medicina, Portugal
2020/12	Crosslinking Immunity and Metabolism during Leishmania Infection Arguente	Inês Morais Mesquita (Doutoramento) Universidade do Minho Escola de Medicina, Portugal
2020/10	Thymic infection and T cell immunodominance during Mycobacterium avium infection Arguente	Bruno Miguel Cerqueira Rodrigues (Doutoramento) Universidade do Minho Escola de Medicina, Portugal
2016/11	Immunogenetic determinants of susceptibility/resistance to Mycobacterium ulcerans infection: a population based study - Benin biological bank on Buruli ulcer Arguente	Carlos Alberto Pereira Capela (Doutoramento) Universidade do Minho Escola de Medicina, Portugal

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2012 - Atual	Member of Lab-PTBioNet: ICVS, UMinho representative: The Portuguese Biosafety Laboratory Network, Lab-PTBioNet, has the mission to pomote a Biosafety laboratory policy and implement good Biosafety practices in all biological safety level 3 (BSL-3) laboratories in Portugal. Membro	Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2012 - Atual	ICVS Biosafety Coordinator for BSL3: engaged in the implementation and dissemination of institutional and personal preventive measures to promote the safe handling of biological agents and reduce the risk of individual exposure and avoid the risk of intentional removal or misuse of a biological agent with the intention of causing harm. Coordenador
2020 - 2021	ICVS member of the COVID-19 diagnostic team: team leader of the inactivation station for COVID-19 diagnostics Membro	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2021	Member of the Technical Committee: member of CT207 for the translation of ISO 35001:2021 - Biorisk management for laboratories and other related organisations Membro

Distinções

Prémio

2019	Best Poster Award at Microbiotec19 for the work: Statins as new candidates for the treatment of Buruli Ulcer
2010	Pulido Valente Ciência Award with the work: Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis J. Exp. Med., 2010; 207(8): 1609-16
2010	Best Paper Award from the Portuguese Society for Immunology, with the work: Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J. Exp. Med., 2010; 207(8): 1609-16
2006	Excellence Award in Immunology Mário Arala Chaves at the Portuguese Society for Immunology, with the work: Th17 cells inducing a massive recruitment of neutrophils may play a role in Koch reaction.