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Sérgio de Almeida is a Group Leader at the Institute of Molecular Medicine João Lobo Antunes (iMM-JLA) and an Associate Professor with Habilitation at the Faculty of Medicine of the University of Lisbon. His research focuses on the mechanisms that control chromatin dynamics during transcription and DNA damage repair and how they coordinate with the processes that safeguard genome integrity. To this end, the lab employs a multidisciplinary research strategy that combines experimental tools and approaches from areas such as cell and molecular biology, biochemistry, live-cell microscopy, next-generation sequencing and bioinformatics. He has published several original research papers in journals such as Nature Structural and Molecular Biology, Science Advances, eLife, Nucleic Acids Research, Cell Reports, Molecular Cell, and Genome Research. His work was cited over 2000 times (h index=21) and received several prestigious national and international awards including the Pfizer Award for basic research. Sérgio de Almeida is the inventor of two patents, supervised 8 PhD students (4 completed), and 5 post-doctoral fellows. His research was funded through competitive grants from different agencies totalling more than ¿1M euros.
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Identificação

Identificação pessoal

Nome completo
SÉRGIO ALEXANDRE FERNANDES DE ALMEIDA

Nomes de citação

  • DE ALMEIDA, SÉRGIO F.
  • DE ALMEIDA, SÉRGIO FERNANDES

Identificadores de autor

Ciência ID
7D18-F40F-7CC1
ORCID iD
0000-0002-7774-1355

Telefones

Telemóvel
  • (+351) 919364201 (Pessoal)

Moradas

  • Instituto de Medicina Molecular João Lobo Antunes Faculdade de Medicina da Universidade de Lisboa Av. Professor Egas Moniz , 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana
  • Ciências Médicas e da Saúde - Medicina Clínica - Oncologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2022
Concluído
 Agregação (Habilitation) em Biologia Molecular (Título de Agregado)
Universidade de Lisboa Faculdade de Medicina, Portugal
""From Transcription to DNA damage and back again" " (TESE/DISSERTAÇÃO)
2007
Concluído
 Ciências Biomédicas (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Study of the Immunological Role of Hfe Mutations" (TESE/DISSERTAÇÃO)
 N/A
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/06/01 - Atual Investigador principal (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
2008/10/01 - 2013/05/31 Pós-doutorado (Investigação) Instituto de Medicina Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/09/01 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
2013/12/01 - 2023/08/31 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2021/03/01 - 2024/02/29 Decoding the Role of DNA Break-Induced Transcription in Ageing
PTDC/MED-OUT/4301/2020
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/09/01 - 2022/08/31 RNA in disease — RiboMed
GA 857119 - H2020-WIDESPREAD
Investigador
Horizon 2020
Em curso
2018/08/01 - 2021/07/31 A critical role for DNA damage in transcription that impacts cell differentiation and tumor development
PTDC/BIA-MOL/30438/2017
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 Targeted DNA Damage as a novel tumor suppressor tool
IMM-LAÇO-FUND
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Instituto de Medicina Molecular
Concluído
2016/12 - 2019/09 Accelerating progress toward the new era of precision medicine
SAICTPAC/0021/2015
 Fundação para a Ciência e a Tecnologia
2016/07 - 2019/06 Novel tumorigenic mechanisms of aberrant epigenetic regulation in clear cell renal cell carcinoma
PTDC/BIM-ONC/0016/2014
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/01/01 - 2018/12/31 Targeting R-loop suppressors in estrogen-dependent breast cancer cells
IMM-LAÇO-FUND
Investigador responsável
Instituto de Medicina Molecular
Concluído
2014/03/01 - 2017/02/28 Epigenetics and alternative splicing: role in immune T cell differentiation and leukemogenesis
FCT-ANR/BIM-ONC/0009/2013
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013/06 - 2015/11 SETD2 mediates a novel tumor suppressor mechanism that is misregulated in clear cell renal carcinoma
Provided by PTCRIS: 124736
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2011/02 - 2014/01 Splicing-coupled mechanisms of chromatin remodeling and their global role in transcription
Provided by PTCRIS: 111451
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
Concluído
Produções

Publicações

Artigo em revista
  1. Cardoso BA; Duque M; Gírio A; Fragoso R; Oliveira ML; Allen JR; Martins LR; et al. "CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.". Haematologica (2023): http://europepmc.org/abstract/med/38058200.
    10.3324/haematol.2023.282854
  2. Faleiro I; Afonso AI; Balsinha A; Lucas B; Martin RM; Gomes ER; de Almeida SF. "Adaptive changes in the DNA damage response during skeletal muscle cell differentiation.". Frontiers in cell and developmental biology (2023): http://europepmc.org/abstract/med/38089884.
    10.3389/fcell.2023.1239138
  3. Robert M Martin; Madalena R de Almeida; Eduardo Gameiro; de Almeida SF. "Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamics". Nucleic Acids Research (2023): http://dx.doi.org/10.1093/nar/gkad812.
    10.1093/nar/gkad812
  4. Angelo Ferreira Chora; Dora Pedroso; Eleni Kyriakou; Nadja Pejanovic; Henrique. G. Colaço; Raffaella Gozzelino; André Barros; et al. "DNA damage independent inhibition of NF-¿B transcription by anthracyclines". eLife 11 (2022): http://dx.doi.org/10.7554/elife.77443.
    10.7554/elife.77443
  5. Sabino, João C; de Almeida, Madalena R; Abreu, Patrícia L; Ferreira, Ana M; Caldas, Paulo; Domingues, Marco M; Santos, Nuno C; et al. "Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops". eLife 11 (2022): http://dx.doi.org/10.7554/elife.69476.
    10.7554/elife.69476
  6. Gomes, Edgar R.; de Almeida, Sérgio F.. "TREX1-dependent DNA damage links nuclear rupture to tumor cell invasion". Developmental Cell 56 22 (2021): 3040-3041. http://dx.doi.org/10.1016/j.devcel.2021.11.003.
    10.1016/j.devcel.2021.11.003
  7. de Almeida, Madalena R.; Gameiro, Eduardo; de Almeida, Sérgio F.; Martin, Robert M.. "Live-Cell Imaging of Transcriptional Activity at DNA Double-Strand Breaks". Journal of Visualized Experiments 175 (2021): http://dx.doi.org/10.3791/62968.
    10.3791/62968
  8. Francesco Roncato; Ofer Regev; Sara W. Feigelson; Sandeep Kumar Yadav; Lukasz S. Kaczmarczyk; Nehora Levi; Diana Drago-Garcia; et al. "Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis". Cancers (2021): https://www.mdpi.com/2072-6694/13/10/2383.
    10.3390/cancers13102383
  9. Sardoo, A. M.; Neto, A.; Torres, Pinheiro R.; Rodrigues-Manica, S.; Domingues, L.; Crespo, Lage C.; Lagoas-Gomes, J.; et al. "The role of muscle in the susceptibility and progression of axial Spondyloarthritis: The MyoSpA study protocol". Acta Reumatologica Portuguesa (2021): https://publons.com/wos-op/publon/52096570/.
  10. Alexandra C. Vítor; Pablo Huertas; Gaëlle Legube; Sérgio F. de Almeida. "Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox". Frontiers in Molecular Biosciences 7 (2020): https://doi.org/10.3389%2Ffmolb.2020.00024.
    10.3389/fmolb.2020.00024
  11. de Matos, Mafalda; Posa, Ioana; Carvalho, Filipa; Morais, Vanessa; Grosso, Ana; de Almeida, Sérgio. "A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers". Cancers 11 3 (2019): 391. http://dx.doi.org/10.3390/cancers11030391.
    10.3390/cancers11030391
  12. Alexandra C. Vítor; Sreerama C. Sridhara; João C. Sabino; Ana I. Afonso; Ana R. Grosso; Robert M. Martin; Sérgio F. de Almeida. "Single-molecule imaging of transcription at damaged chromatin". Science Advances 5 1 (2019): eaau1249-eaau1249. https://doi.org/10.1126%2Fsciadv.aau1249.
    10.1126/sciadv.aau1249
  13. Helga B Landsverk; Lise E Sandquist; Sreerama C Sridhara; Gro Elise Rødland; João C Sabino; Sérgio F de Almeida; Beata Grallert; Laura Trinkle-Mulcahy; Randi G Syljuåsen. "Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1". Nucleic Acids Research (2018): https://doi.org/10.1093%2Fnar%2Fgky1233.
    10.1093/nar/gky1233
  14. Amandine Bonnet; Ana R. Grosso; Abdessamad Elkaoutari; Emeline Coleno; Adrien Presle; Sreerama C. Sridhara; Guilhem Janbon; et al. "Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability". Molecular Cell 67 4 (2017): 608-621.e6. https://doi.org/10.1016%2Fj.molcel.2017.07.002.
    10.1016/j.molcel.2017.07.002
  15. Sreerama Chaitanya Sridhara; Sílvia Carvalho; Ana Rita Grosso; Lina Marcela Gallego-Paez; Maria Carmo-Fonseca; Sérgio Fernandes de Almeida. "Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation". Cell Reports 18 2 (2017): 334-343. https://doi.org/10.1016%2Fj.celrep.2016.12.050.
    10.1016/j.celrep.2016.12.050
  16. Ana Rita Grosso; Ana Paula Leite; Sílvia Carvalho; Mafalda Ramos Matos; Filipa Batalha Martins; Alexandra Coitos Vítor; Joana MP Desterro; Maria Carmo-Fonseca; Sérgio Fernandes de Almeida. "Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma". eLife 4 (2015): http://dx.doi.org/10.7554/elife.09214.
    10.7554/elife.09214
  17. Sérgio Fernandes de Almeida; Maria Carmo-Fonseca. "Reciprocal regulatory links between cotranscriptional splicing and chromatin". Seminars in Cell & Developmental Biology (2014):
    10.1016/j.semcdb.2014.03.010
  18. V. G. da Gloria; M. Martins de Araujo; A. Mafalda Santos; R. Leal; S. F. de Almeida; A. M. Carmo; A. Moreira. "T Cell Activation Regulates CD6 Alternative Splicing by Transcription Dynamics and SRSF1". The Journal of Immunology 193 1 (2014): 391-399. http://dx.doi.org/10.4049/jimmunol.1400038.
    10.4049/jimmunol.1400038
  19. Sílvia Carvalho; Alexandra C Vítor; Sreerama C Sridhara; Filipa B Martins; Ana C Raposo; Joana MP Desterro; João Ferreira; Sérgio F de Almeida. "SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint". eLife 3 (2014): http://dx.doi.org/10.7554/elife.02482.
    10.7554/elife.02482
  20. Carvalho, S.; Raposo, A.C.; Martins, F.B.; Grosso, A.R.; Sridhara, S.C.; Rino, J.; Carmo-Fonseca, M.; De Almeida, S.F.. "Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription". Nucleic Acids Research 41 5 (2013): 2881-2893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876365300&partnerID=MN8TOARS.
    10.1093/nar/gks1472
  21. Grosso, A.R.; De Almeida, S.F.; Braga, J.; Carmo-Fonseca, M.. "Dynamic transitions in RNA polymerase II density profiles during transcription termination". Genome Research 22 8 (2012): 1447-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864577725&partnerID=MN8TOARS.
    10.1101/gr.138057.112
  22. de Almeida, S.F.; Carmo-Fonseca, M.. "Design principles of interconnections between chromatin and pre-mRNA splicing". Trends in Biochemical Sciences 37 6 (2012): 248-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861925259&partnerID=MN8TOARS.
    10.1016/j.tibs.2012.02.002
  23. De Almeida, S.F.; Grosso, A.R.; Koch, F.; Fenouil, R.; Carvalho, S.; Andrade, J.; Levezinho, H.; et al. "Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36". Nature Structural and Molecular Biology 18 9 (2011): 977-983. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052445151&partnerID=MN8TOARS.
    10.1038/nsmb.2123
  24. Cardoso, B.A.; De Almeida, S.F.; Laranjeira, A.B.A.; Carmo-Fonseca, M.; Yunes, J.A.; Coffer, P.J.; Barata, J.T.. "TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells". Leukemia 25 10 (2011): 1578-1586. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054032532&partnerID=MN8TOARS.
    10.1038/leu.2011.140
  25. De Almeida, S.F.; Carmo-Fonseca, M.. "Cotranscriptional RNA checkpoints". Epigenomics 2 3 (2010): 449-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954093775&partnerID=MN8TOARS.
    10.2217/epi.10.21
  26. De Almeida, S.F.; García-Sacristán, A.; Custódio, N.; Carmo-Fonseca, M.. "A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination". Nucleic Acids Research 38 22 (2010): 8015-8026. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650445002&partnerID=MN8TOARS.
    10.1093/nar/gkq703
  27. Martins, S.B.; Rino, J.; Carvalho, T.; Carvalho, C.; Yoshida, M.; Klose, J.M.; De Almeida, S.F.; Carmo-Fonseca, M.. "Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3' end of human genes". Nature Structural and Molecular Biology 18 10 (2010): 1115-1123. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455164573&partnerID=MN8TOARS.
    10.1038/nsmb.2124
  28. Oliveira, S.J.; Pinto, J.P.; Picarote, G.; Costa, V.M.; Carvalho, F.; Rangel, M.; de Sousa, M.; de Almeida, S.F.. "ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity". PLoS ONE 4 8 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-68949162173&partnerID=MN8TOARS.
    10.1371/journal.pone.0006618
  29. De Almeida, S.F.; De Sousa, M.. "The unfolded protein response in hereditary haemochromatosis: Molecular Medicine". Journal of Cellular and Molecular Medicine 12 2 (2008): 421-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-42349086509&partnerID=MN8TOARS.
    10.1111/j.1582-4934.2007.00179.x
  30. Pinto, J.P.; Ramos, P.; de Almeida, S.F.; Oliveira, S.; Breda, L.; Michalak, M.; Porto, G.; Rivella, S.; de Sousa, M.. "Protective role of calreticulin in HFE hemochromatosis". Free Radical Biology and Medicine 44 1 (2008): 99-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-36249031555&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2007.09.014
  31. de Almeida, S.F.; Carmo-Fonseca, M.. "The CTD role in cotranscriptional RNA processing and surveillance". FEBS Letters 582 14 (2008): 1971-1976. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449142796&partnerID=MN8TOARS.
    10.1016/j.febslet.2008.04.019
  32. S. F. de Almeida; J. V. Fleming; J. E. Azevedo; M. Carmo-Fonseca; M. de Sousa. "Stimulation of an Unfolded Protein Response Impairs MHC Class I Expression". The Journal of Immunology 178 6 (2007): 3612-3619. http://dx.doi.org/10.4049/jimmunol.178.6.3612.
    10.4049/jimmunol.178.6.3612
  33. De Almeida, S.F.; Picarote, G.; Fleming, J.V.; Carmo-Fonseca, M.; Azevedo, J.E.; De Sousa, M.. "Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation". Journal of Biological Chemistry 282 38 (2007): 27905-27912. http://www.scopus.com/inward/record.url?eid=2-s2.0-34948859111&partnerID=MN8TOARS.
    10.1074/jbc.M702672200
  34. Pinto, Jorge P.; Ramos, Pedro; de Almeida, Sergio; Oliveira, Susana; Breda, Laura; Michalak, Marek; Rivella, Stefano; de Sousa, Maria. "Role of HFE in hepatic iron overload: Novel findings demonstrate direct effects of mutant C282Y on hepcidin and calreticulin mRNA expression". Blood (2006): https://publons.com/wos-op/publon/5255867/.
    10.1182/BLOOD.V108.11.1549.1549
  35. De Almeida, S.F.; Carvalho, I.F.; Cardoso, C.S.; Cordeiro, J.V.; Azevedo, J.E.; Neefjes, J.; De Sousa, M.. "HFE cross-talks with the MHC class I antigen presentation pathway". Blood 106 3 (2005): 971-977. http://www.scopus.com/inward/record.url?eid=2-s2.0-23044509138&partnerID=MN8TOARS.
    10.1182/blood-2004-12-4640
Pré-impressão
  1. Pérez-Rico, Yuvia A; Bousard, Aurélie; Misikova, Lenka Henao; Mulugeta, Eskeatnaf; de Almeida, Sérgio F; Muotri, Alysson R; Heard, Edith; Gendrel, Anne-Valerie. "Transcriptional perturbation of LINE-1 elements reveals theircis-regulatory potential". 2024. http://dx.doi.org/10.1101/2024.02.20.581275.
    10.1101/2024.02.20.581275

Propriedade Intelectual

Pedido provisório de patente
  1. 2023. "A Genetically Encoded Sensor for Live-Cell Imaging of R-loops".
    Divulgado
  2. 2023. "Induction of Cellular Lethality in Cancer".
    Divulgado
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/10/25 Live-Cell Imaging Unveils Distinct R-loop Populations with Heterogeneous Dynamics Spanish/Portuguese Meeting for Advanced Optical Microscopy
Spanish/Portuguese Society of Advanced Optical Microscopy (Faro, Portugal)
2023/10/13 Live-Cell Imaging of R-loops and Their Impact on Gene Expression Dunn School of Pathology Research Seminars, Oxford University
Dr Monika Gullerova (Oxford, Reino Unido)
2020/10/13 Exploring the crosstalk between transcription and DNA damage Columbia University Irving Medical Center
Rodney Rothstein (New York, Estados Unidos)
2020/04/21 Reciprocal regulatory links between transcription and DNA repair 3rd Institut Curie Course on Genome Instability and Human Disease
Invited Speaker (Paris, França)
2020/02/21 Dynamic interactions between transcription and DNA damage 1st CABIMER International Workshop - Trends in Genome Integrity & Chromosome Dynamics
Invited Speaker (Seville, Espanha)
2019/04/01 Reciprocal regulatory links between transcription and DNA repair Research Seminar at the IFOM-IEO
Invited by Fabrizio d’Adda di Fagagna (Milão, Itália)
2019/02/25 Imaging DNA Break-Induced Transcription in Live Cells Spatial Genome Organization Conference - The Nucleome in Basic Biology and Disease
Invited Speaker (Nassau, Bahamas)
2019/01/24 Single-molecule imaging of transcription at damaged chromatin RNA meeting, ptRNA
Invited Speaker (Porto, Portugal)
2019/01/11 Live cell imaging of DNA Break-Induced Transcription Research Seminar, Jinan University
Invited Speaker (Guangzhou, China)
2018/12/05 Single-molecule imaging of DNA break-induced transcription initiation Symposium on Tumor Biology
Invited Speaker (Lisboa, Portugal)
2018/10/10 Reciprocal interactions between transcription and DNA repair EMBO Workshop - RNA and genome maintenance
Invited Speaker (Mainz, Alemanha)
2018/05/18 Single-molecule imaging of transcription at damaged chromatin IGC seminar series
Invited Speaker (Oeiras, Portugal)
2018/02/16 Reciprocal regulatory links between transcription and DNA repair Cabimer Research Seminars
Invited by Andres Aguilera (Seville, Espanha)
2018/01/18 At the intersection of chromatin structure, transcription and DNA repair Dunn School of Pathology Research Seminars
Invited by Nick Proudfoot (Oxford, Reino Unido)
2017/05/28 Outcome of epigenetic deregulation in cancer ReTuBi Joint Summer School 2017
Invited Speaker (Lisboa, Portugal)
2016/11/16 Transcription as a major modulator of Genome Stability UCBiotech seminars
Invited Speaker (Cantanhede, Portugal)
2016/04/18 Safeguarding the integrity of genetic information Epigenetics – From mechanisms to disease, ICVS
Invited Speaker (Braga, Portugal)
2016/01/13 Transcription dynamics drives the suppression of RNA-mediated genomic instability BioFig seminars
Invited Speaker (Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2014/01/01 - Atual Co-Supervisor of 5 PhD theses
Coorientador de Rui Traquete; Marie Bordone; Patricia Abreu; Nuno Agostinho; Andreia Pena;
Universidade de Lisboa Faculdade de Medicina, Portugal
2013/04/30 - Atual PhD theses: Supervisor of 4 completed PhD theses (Sreerama C Sridhara 2017; Alexandra C Vitor 2018; Mafalda R Matos 2019; João Sabino 2022) and 3 ongoing PhD theses (Inês Faleiro; Madalena Almeida; Cristiana Morgado). All theses developed at the Medical School of ULisboa.
Orientador de Supervisor of S. Sridhara; A. Vitor; M. Matos; J. Sabino; I. Faleiro; M. Almeida; C. Morgado.
Universidade de Lisboa Faculdade de Medicina, Portugal
2013/01/01 - Atual Supervisor of 14 completed MSc theses: - 2022/23 André Balsinha - 2022/23 Ian Teixeira - 2021/22 Ana Rita Marques - 2021/22 Maria Luísa Alvarenga - 2020/21 Inês Mendes Dias - 2018/19 Madalena Reto Almeida - 2017/18 Beatriz Lucas - 2017/18 Cristiana Morgado - 2015/16 João Sabino - 2015/16 Ana Duarte - 2012/13 Alexandra Vitor - 2011/12 Sílvia Carvalho - 2011/12 Filipa Martins - 2010/11 Ana Raposo
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2012/01/26 - Atual Portuguese RNA Meeting 2012, Lisboa, Portugal (2012/01/26 - 2012/01/27)
Congresso (Coorganizador)
2023/01/26 - 2023/01/27 International RiboMed meeting - "RNA in Disease", Lisboa, Portugal (2023/01/26 - 2023/01/27)
Congresso (Coorganizador)
2018/07/03 - 2018/07/05 Nuclear and Mitochondria Instability in Health and Cancer” International Scientific Symposim, Montargil, Portugal (2018/07/03 - 2018/07/05)
Congresso (Coorganizador)

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/04/30 Since 2014 - Main examiner of 16 PhD theses. 6 in international univ.: ¿ Oct 12, 2023 - Zhichao Liu, Oxford Uni. Supervisor: Dr Monika Gullerova. ¿ Jun 19, 2023 - Vanessa Pires, Johannes Gutenberg Uni. Sup: Dr Brian Luke. ¿ Apr 12, 2023 - Cristina Mendonza, Uni de Sevilla. Sup: Dr Andrés Aguilera. ¿ Jan 17, 2018 - Jonathan Foxwell, Oxford Uni. Sup: Dr Nicholas Proudfoot. ¿ Jul 14, 2015 - Isac Kremsky,Uni Pompeu Fabra, Barcelona. Sup: Dr Eduardo Eyras ¿ Jun 30, 2015 - Valeria Runfola, Uni. Vita-Salute San Rafaele, Milan. Sup. Dr Davide Gabellini
Arguente principal
 16 Candidates (10 in Portuguese Universities and 6 in International universities) (Doutoramento)
2020/04/30 Main examiner of 12 MSc theses since 2014
Arguente principal
 12 MSc Candidates (Mestrado)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023 - Atual Chair of “Genomic Instability in Cancer” of the Master in Oncobiology, Faculty of Medicine of the University of Lisbon Mestrado em Oncobiologia, Faculty of Medicine of the University of Lisbon
2021 - Atual Chair of the curricular units “Advanced Techniques in Biomedical Research II” and “Laboratory Internship II” (since 2021) of the Master in Biomedical Research - Instituto de Medicina Molecular, University of Lisbon Mestrado em Investigação Biomédica Instituto de Medicina Molecular, Portugal
2014/03/01 - Atual Oncobiology Medicina (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - Atual Chair of “Molecular & Cell Biology” of the Lisbon BioMed PhD Program Programa Doutoral do Centro Académico de Medicina de Lisboa (ramo de Medicina; ramo de Ciências Biomédicas; ramo de Ciências e Tecnologias da Saúde) Universidade de Lisboa Faculdade de Medicina, Portugal
2013/09/16 - Atual Molecular Biology of the Cell Medicina (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2013 - 2024 I gave several personal interviews related to my scientific activities that were published by Portuguese media (SIC TV; TVI; CiênciaHoje.pt; Agência Lusa; Jornal Público; Revista Visão; TV Ciência). Some examples: - Outreach activity (Video 2018): https://www.youtube.com/watch?v=AxxzKCMsWpI - Outreach activity (Video 2021): https://www.youtube.com/watch?v=ll1jYH4Usq4&t=15s - Interview about my work in the main daily newspaper in Portugal: https://www.publico.pt/2022/06/06/ciencia/noticia/arn-adn-formam-determinam-destino-celulas-2008904

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2022 - Atual Member of the Commission for Gender Equality, Inclusion and Non-Discrimination (CIIIND) of the Medical School of the University of Lisbon.
Membro
2022 - Atual Member of the Scientific Committee of the Master in Biomedical Research - Instituto de Medicina Molecular JLA, University of Lisbon
Membro
 Instituto de Medicina Molecular, Portugal
2019 - Atual Elected representative of the Investigators for the General Assembly of Instituto de Medicina Molecular João Lobo Antunes

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2017/01/01 - Atual Editorial Tasks: - Guest Associate Editor of Frontiers in Cell and Developmental Biology - Guest Associate Editor of Frontiers in Molecular Biosciences - Frontiers Topic Editor (with Drs Pablo Huertas & Gael Legube): “Regulation of DNA Double Strand Break Repair by Local Chromatin Architecture” - Invited Editor of Journal of Molecular Biology. Special issue on “RNA-dependent genomic instability”
2014/01/01 - Atual Grant Review: - Grant Reviewer for the European Commission, Expert + Rapporteur, H2020 MSCA fellowships (2018; 2019; 2020; 2021; 2022; 2023) - Grant Reviewer for the Research Grant Council (RGC) of Hong Kong (2019; 2020) - Grant Reviewer for the Polish National Science Centre (2018) - Grant Reviewer for the French Agence Nationale de la Recherche (ANR) (2016; 2018; 2019) - Grant Reviewer for the Prostate Cancer Research UK (2016) - Grant Reviewer for the Dutch Cancer Society (2014)
2013/01/01 - Atual Manuscript Review: Ad hoc reviewer of articles submitted to the journals: “Nature Cancer”, “Nature Communications”, “Molecular Cell”, “Cell Reports”, “Nucleic Acids Research”, “eLife”, “Genome Research”, “Journal of Cell Science”, “Transcription”, “Cancer Research”, “BMC Genomics” and “Pharmacogenomics”
Distinções

Prémio

2015 Portuguese Society of Human Genetics Award
Portuguese Society of Human Genetics, Portugal
2011 Pfizer Award for Basic Research
2006 LabMed Science Award
2005 Pulido Valente Science Award (Honours)
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2017 Nominated member of the Young Scientists Seminar of the Lisbon Academy of Sciences
Academia das Ciências de Lisboa, Portugal
2013 Associate Member of EpiGeneSys - European network of excellence