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João Luz is a biochemist whose interests revolve around untargeted metabolomics, high-resolution analytic techniques and computational data analysis using Machine Learning and statistical methods. Attending the Faculty of Sciences of the, University of Lisbon (FCUL), he obtained a Bachelor of Science degree in Biochemistry in July 2018, followed by a Master of Science degree in Biochemistry in February 2021. From October 2017 to July 2018, he conducted research as an intern at the FT-ICR and Structural Mass Spectrometry Laboratory of FCUL (FT-ICR-MS-Lisboa), where he acquired extensive scientific knowledge and practical skills important to the experimental practice of biochemistry, including experience in the growth and propagation of yeasts (wildtype and mutants), preparation of metabolite extracts and metabolomic analysis with fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). His masters' dissertation, entitled "Metabolomic effects of single gene deletions in Saccharomyces Cerevisae", also developed at the FT-ICR-MS-Lisboa laboratory, focused on the development of an FT-ICR-MS-based untargeted metabolomics approach for the differentiation of mutant yeast strains with the same genetic backgrounds. It was classified with a value of 19 out of 20. This same research later resulted in posters exposed at the X-omics festival 2021, the 2nd Chem & Biochem Students meeting at FCUL and the 14th European Fourier Transform Mass Spectrometry Workshop & 3rd EFTMS School, as well as in a Bruker application note (MRMS 75). João is currently a member of the team working on a project entitled "Wine yeasts typing: discrimination of non-conventional wine yeasts through untargeted chemical fingerprinting," as well as a recipient of a research fellowship from the "European Network of Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry Centers," funded by the European Union. In addition to his experimental research skills, João is also knowledgeable about multivariate statistical analysis techniques (PCA, HCA, etc), as well as Machine Learning (PLS-DA, RFs), familiar with specific data analysis software for FT-ICR-MS (Metaboscape), and proficient in Python programming, with a specific focus on the scientific applications of the programming language. He co-authored two papers entitled "Binary simplification as a useful tool in metabolomics" and "Graph Properties of Mass-Difference Networks for Profiling and Discrimination in Untargeted Metabolomics," where he proposed novel approaches for the treatment FT-ICR metabolomics data. This particular combination of skills in microbiology, high-resolution analytic techniques and computational data analysis allows him to autonomously develop scientific projects with a high degree of complexity and multidisciplinary character.
Identificação

Identificação pessoal

Nome completo
João Luz

Nomes de citação

  • Luz, João

Identificadores de autor

Ciência ID
7C17-5CEB-970F
ORCID iD
0000-0003-4000-4068

Moradas

  • Av das Laranjeiras 16 7º D, Alfragide, 2610-098, Alfragide, Amadora, Portugal (Pessoal)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2022/01 - 2026/01
Em curso
Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09 - 2021/02
Concluído
Bioquímica (Mestrado)
Especialização em Bioquímica
Universidade de Lisboa Faculdade de Ciências, Portugal
"Metabolomic effects of single gene deletions in Saccharomyces cerevisiae" (TESE/DISSERTAÇÃO)
17
2015/09/05 - 2018/06/27
Concluído
Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
14
2012 - 2015
Concluído
Curso de Ciências e Tecnologia (Ensino secundário)
Externato Marista de Lisboa, Portugal
16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2022/01/01 - Atual Investigador (Investigação) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/10 - 2018/06 Estagiário de Investigação (Investigação) Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
Projetos

Bolsa

Designação Financiadores
2023/09/01 - 2023/12/31 From fragments to high affinity binders interfacing integrated structural biology, medicinal chemistry and artificial intelligence
HORIZON-INFRA-2022-TECH-01-01-101094131
Bolseiro de Investigação
2021/12/07 - 2022/12/07 European Network of Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry Centers
H2020-INFRAIA-731077
Bolseiro de Investigação
Universidade de Lisboa Faculdade de Ciências, Portugal
European Union

Projeto

Designação Financiadores
2022/01/01 - Atual Wine yeasts typing: discrimination of non-conventional wine yeasts through untargeted chemical fingerprinting
EXPL/BTA-BTA/1389/2021
Investigador
Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em boletim informativo
  1. Sousa Silva, Marta; Luz, João; Pendão, Ana Sofia; Cordeiro, Carlos. "Magnetic Resonance Mass Spectrometry (MRMS) discriminates yeast mutants through metabolomics", MRMS 75 - Metabolomics of Yeast Mutants, 2021, https://www.bruker.com/en/products-and-solutions/mass-spectrometry/mrms.html.
Artigo em revista
  1. Ana M Santos; Ana Soares; Luz, João; Cordeiro, Carlos; Silva, Marta Sousa; Teresa Dias; Juliana Melo; Cristina Cruz; Luís Carvalho. "Microbial interactions as a sustainable tool for enhancing PGPR antagonism against phytopathogenic fungi". Sustainability (2024):
    Aceite para publicação
  2. Nogues, Isabel; Passatore, Laura; Bustamante, María Ángeles; Pallozzi, Emanuele; Luz, João; Traquete, Francisco; Ferreira, António; Sousa Silva, Marta; Cordeiro, Carlos. Autor correspondente: Sousa Silva, Marta. "Cultivation of Melilotus officinalis as a source of bioactive compounds in association with soil recovery practices". Frontiers in Plant Science 14 (2023):
    Publicado
  3. Traquete, Francisco; Luz, João; Cordeiro, Carlos; Sousa Silva, Marta; Ferreira, António E. N.. "Graph Properties of Mass-Difference Networks for Profiling and Discrimination in Untargeted Metabolomics". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.917911.
    Publicado • 10.3389/fmolb.2022.917911
  4. Francisco Traquete; João Luz; Carlos Cordeiro; Marta Sousa Silva; António E. N. Ferreira. "Binary Simplification as an Effective Tool in Metabolomics Data Analysis". Metabolites (2021): https://doi.org/10.3390/metabo11110788.
    10.3390/metabo11110788
Poster em conferência
  1. Luz, João; Traquete, Francisco; António E. N. Ferreira; Marta Sousa Silva; Carlos Cordeiro. "Towards a score-based metabolite identification algorithm for extreme resolution mass spectrometry". Trabalho apresentado em 3rd Chem & BiochemStudents Meeting, 2023.
  2. Pereira, Mariana; Luz, João; Gomes, Nelson G.M.; Cordeiro, Carlos; Carvalho, Áurea Madureira; Sousa Silva, Marta. "Revealing the Chemical World of Fingermarks through FT-ICR-MS". Trabalho apresentado em 14th European Fourier Transform Mass Spectrometry Workshop & 3rd EFTMS School, 2022.
  3. Traquete, Francisco; Luz, João; Cordeiro, Carlos; Silva, Marta Sousa; Ferreira, Antonio. "Spectral feature occurrence as a viable alternative to intensity-based data for profiling and discrimination in untargeted metabolomics". Trabalho apresentado em 2nd Chem & BiochemStudents Meeting, 2022.
  4. Luz, João; Pendão, Ana Sofia; Traquete, Francisco; Ferreira, António; Sousa Silva, Marta; Cordeiro, Carlos. "A metabolomics approach to the study of the effects of single-gene deletions in yeast". Trabalho apresentado em 2nd Chem & BiochemStudents Meeting, 2022.
  5. Pereira, Mariana; Luz, João; Gomes, Nelson; Cordeiro, Carlos; Madureira-Carvalho, Áurea; Sousa Silva, Marta. "Revealing the Chemical Universe of Fingermarks by FT-ICR-MS". Trabalho apresentado em 2nd Chem & Biochem Students Meeting, 2022.
  6. Osawa, Rodrigo; Louro, Mariana; Soeiro, Mónica; Luz, João; Marques, Ana; Ferreira, António; Sousa Silva, Marta; Cordeiro, Carlos. "From Grapevine to the dinning table: unprecedented approach using FT-ICR-MS". Trabalho apresentado em 14th European Fourier Transform Mass Spectrometry Workshop & 3rd EFTMS School, 2022.
  7. Luz, João; Pendão, Ana Sofia; Traquete, Francisco; Ferreira, António; Silva, Marta Sousa; Cordeiro, Carlos. "FT-ICR-MS uncovers large-scale metabolic differences between phenotypically identical yeasts". Trabalho apresentado em 14th European Fourier Transform Mass Spectrometry Workshop & 3rd EFTMS School, 2022.
  8. Traquete, Francisco; Luz, João; Cordeiro, Carlos; Silva, Marta Sousa; Ferreira,António. "Using Graph Properties of Mass-Difference Networks for Profiling and Discrimination in Untargeted Metabolomics". Trabalho apresentado em 14th European Fourier Transform Mass Spectrometry Workshop & 3rd EFTMS School, 2022.
  9. Traquete, Francisco; Luz, João; Sousa Silva, Marta; Cordeiro, Carlos; Ferreira, António. "Spectral feature occurrence as a complementary approach to intensity-based data for profiling and discrimination in untargeted metabolomics". Trabalho apresentado em Metabolomics 2022 (18th International Conference of the Metabolomics Society), 2022.
  10. Luz, João; Pendão, Ana Sofia; Traquete, Francisco; Ferreira, António; Sousa Silva, Marta; Cordeiro, Carlos. "Metabolomic effects of single-gene deletions in Saccharomyces cerevisae". Trabalho apresentado em X-Omics Festival 2021, 2021.
  11. Traquete, Francisco; Luz, João; Cordeiro, Carlos; Sousa Silva, Marta; Ferreira, António. "Binary Similarity Measures as an Effective Tool in Metabolomics Data Analysis". Trabalho apresentado em X-Omics Festival 2021, 2021.
Tese / Dissertação
  1. Luz, João. "Metabolomic effects of single gene deletions in Saccharomyces cerevisiae". Mestrado, Universidade de Lisboa Faculdade de Ciências, 2021.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/10/19 Probabilistic metabolite identification in extreme resolution mass spectrometry PathProt 15
IGC - Instituto Gulbekian de Ciências (Oeiras, Portugal)
2022/12/16 The chemical universe in a glass of wine: a tale told through FT-ICR-MS EU-FT-ICR-MS End-User School
University of Lille (Lille, França)
2022/12/14 The metabolic side of glycation EU-FT-ICR-MS End-User School
University of Lille (Lille, França)
2022/10/20 Metabolite identification through mass spectrometry using a probabilistic scoring algorithm PathProt 14
IGC - Instituto Gulbenkian de Ciência (Oeiras, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2022/07/11 - 2022/07/14 14th European Fourier Transform Mass Spectrometry Workshop & 3rd EFTMS School (2022/07/11 - 2022/07/14)
Oficina (workshop)
FT-ICR and Structural Mass Spectrometry Laboratory, MARE-Marine and Environmental Sciences Centre, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2022/11/24 - 2022/11/26 EU_FT-ICR_MS Short Course n° 11 FTICR MS for Cultural Heritage Science EU_FT-ICR_MS Short Course n° 11 FTICR MS for Cultural Heritage Science
Université de Lille Département Chimie, França
2022/11/21 - 2022/11/23 EU_FT-ICR_MS Short Course nº 10 Mass Spectrometry Imaging EU_FT-ICR_MS Short Course nº 10 Mass Spectrometry Imaging
Université de Liège, Bélgica
2022/06/06 - 2022/06/09 Hands-on NMR-based Metabolomics: principles, methods and applications
Oficina (workshop)
Hands-on NMR-based Metabolomics: principles, methods and applications
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2022/03/11 - 2022/03/11 Volunteer at PCSBIO Meeting 2022
Encontro
Portuguese Centre for Integrated Structural Biology (PCISBIO) Meeting 2022
2021/11/02 - 2021/11/05 Face-to-face bioinformatics training course in applied metagenomics
Oficina (workshop)
Gulbenkian Training Programme in Bioinformatics - Applied Metagenomics (AM21)
Instituto Gulbenkian de Ciência, Portugal
2021/10/25 - 2021/10/28 Online course on the basics of light microscopy
Seminário
Basics in Light Microscopy
2021/06/25 - 2021/06/25 MaxQuant Online Summer School 2021 - 12th International Summer School on Computational Mass Spectrometry-Based Proteomics
Oficina (workshop)
MaxQuant Online Summer School 2021 - 12th International Summer School on Computational Mass Spectrometry-Based Proteomics
2021/06/15 - 2021/06/15 Portuguese Centre for Integrated Structural Biology (PCISBIO) Webinar - Instruct-ERIC Portugal
Seminário
Portuguese Centre for Integrated Structural Biology (PCISBIO) Webinar - Instruct-ERIC Portugal
2020/03/27 - 2020/05/22 Virtual Podium 2020 - Short presentations focuses on the "omics" disciplines, with particular emphasis on metabolomics and lipidomics
Seminário
Virtual Podium 2020
2020/05/15 - 2020/05/15 London Proteomics Webinar - MS CoViD Coalition & Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of CoViD-19 Patients & Site-specific Analysis of the SARS-CoV-2 Glycan Shield
Seminário
London Proteomics Webinar - MS CoViD Coalition & Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of CoViD-19 Patients & Site-specific Analysis of the SARS-CoV-2 Glycan Shield
2020/05/01 - 2020/05/01 London Proteomics Webinar - Characterisation and detection of SARS-CoV-2 viral proteins using mass spectrometry-based proteomics & NHS Digital role in response to SARS-CoV-2 outbreak
Seminário
London Proteomics Webinar - Characterisation and detection of SARS-CoV-2 viral proteins using mass spectrometry-based proteomics & NHS Digital role in response to SARS-CoV-2 outbreak
2020/04/22 - 2020/04/22 Bruker webinar: MRMS aXelerate®: LC-free high-throughput metabolomics - Presentations focused on MS-based metabolomics
Seminário
Bruker webinar: MRMS aXelerate®: LC-free high-throughput metabolomics
2017/09/20 - 2017/09/22 5th Portuguese Mass Spectrometry Meeting (PTMS2017)
Encontro
5th Portuguese Mass Spectrometry Meeting (PTMS2017)
Sociedade Portuguesa de Química, Portugal