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António Salgado is a biologist with a PhD in Materials Science and Engineering- Tissue Engineering and Hybrid Materials (2005), and a Habilitation (DSc) in Health Sciences, from the University of Minho. Currently he is a Coordinating Investigator at the Life and Health Sciences Research Institute (ICVS) and Vice-Dean for Research at the School of Medicine - University of Minho. His research interests are focused on the development of innovative therapies for CNS repair, namely on Spinal Cord Injury and Parkinson´s Disease, using stem cells secretome. His main areas of research are: 1) Development of ECM like hydrogels for the transplantation of Mesenchymal Stem Cells into the injured CNS; 2) Role of the secretome of MSCs in neuroprotection and repair, particularly the establishment of novel therapies based on the sole use of MSCs secretome. He is currently an author of more than 170 papers (over 9000 citations; h-Index=50, Scopus), and has delivery over 90 invited talks worldwide. He has served from 2019-2023 as the President of the Portuguese Society for Stem Cells and Cell Therapies, and as he is currently a Specialty Chief Editor for Frontiers in Medical Engineering. He has received several distinctions for his work including the Gulbenkian Award on Cutting Edge Research in Life Sciences, the Prize Melo e Castro for Spinal Cord Injury Research (2013, 2017 and 2021), the University of Minho Prize for Scientific Merit (2023) and the Grunenthal Prize in Basic Research (2023).
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Identificação

Identificação pessoal

Nome completo
António José Braga Osório Gomes Salgado

Identificadores de autor

Ciência ID
7A1F-809B-EC3F

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
Projetos

Bolsa

Designação Financiadores
2024/01/01 - Atual Brain Organoids as Tools to Study the Modulatory Actions of MSCs Secretome
SECRET4PAIN
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação Grünenthal
Em curso
2023/03 - Atual SEC4SCI - Adipose tissue-derived stem cells (ASCs) secretome as a new cell-free based therapeutic for spinal cord injury
SEC4SCI_Resolve
Investigador responsável
Em curso

Projeto

Designação Financiadores
2014 - 2018 BioSecrete - Bioreactors as Tools for Controlling Mesenchymal Stem Cells Secretome: A Focus on Parkinson¿s Disease Regenerative Medicine
IF/00111/2013
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Jonas Campos; Ana T. Palha; Luís S. Fernandes; Jorge R. Cibrão; Tiffany S. Pinho; Sofia C. Serra; Nuno A. Silva; Adina T. Michael-Titus; António J. Salgado. "Modeling Spinal Cord Injury in a Dish with Hyperosmotic Stress: Population-Specific Effects and the Modulatory Role of Mesenchymal Stromal Cell Secretome". International Journal of Molecular Sciences (2025): https://doi.org/10.3390/ijms26073298.
    10.3390/ijms26073298
  2. Lopes, Bruna; Sousa, Ana Catarina; Sousa, Patrícia; de Sousa Moreira, Alícia; Coelho, André Filipe; Atayde, Luís; Salgado, António J.; et al. "In vitro evaluation of dental pulp stem cells for sciatic nerve regeneration: foundations for future in vivo applications". Frontiers in Cell and Developmental Biology 13 (2025): https://doi.org/10.3389/fcell.2025.1528213.
    10.3389/fcell.2025.1528213
  3. de Sousa, Nídia; Correia-Silva, Ariana; Pinho, Andreia G.; Vidinha-Mira, André; Cainé, Laura; Lima, Marta F.; Santos, Diogo J.; et al. "Baclofen modulates the immune response after spinal cord injury with locomotor benefits". British Journal of Pharmacology (2025): https://doi.org/10.1111/bph.17438.
    Publicado • 10.1111/bph.17438
  4. Rito-Fernandes, Sara; Salgado, António J.; Silva, Nuno A.; Monteiro, Susana. "Spinal cord injury–associated disruption of the autonomic immune control: does biological sex matter?". Neural Regeneration Research (2024): https://doi.org/10.4103/nrr.nrr-d-24-01078.
    Publicado • 10.4103/nrr.nrr-d-24-01078
  5. Campos, Jonas; Sampaio-Marques, Belém; Santos, Diogo J; Barata-Antunes, Sandra; Ribeiro, Miguel; Serra, Sofia C.; Pinho, Tiffany S.; et al. Autor correspondente: Salgado, António J.. "Lipid Priming of Adipose Mesenchymal Stromal Cells with Docosahexaenoic Acid: Impact on Cell Differentiation, Senescence and the Secretome Neuroregulatory Profile". Tissue Engineering and Regenerative Medicine 22 1 (2024): 113-128. https://doi.org/10.1007/s13770-024-00679-5.
    10.1007/s13770-024-00679-5
  6. Ribeiro, Miguel; Campos, Jonas; Pinho, Tiffany S.; Sampaio-Marques, Belém; Barata-Antunes, Sandra; Cibrão, Jorge Ribeiro; Araújo, Ricardo; et al. "Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions". Biotechnology Journal 19 7 (2024): http://dx.doi.org/10.1002/biot.202400068.
    Publicado • 10.1002/biot.202400068
  7. Sousa, Carla S.; Monteiro, Andreia; Salgado, António J.; Silva, Nuno A.. "Combinatorial therapies for spinal cord injury repair". Neural Regeneration Research (2024): http://dx.doi.org/10.4103/nrr.nrr-d-24-00061.
    10.4103/nrr.nrr-d-24-00061
  8. Débora Gouveia; Ana Cardoso; Carla Carvalho; Inês Rijo; António Almeida; Óscar Gamboa; Bruna Lopes; et al. "The Role of Early Rehabilitation and Functional Electrical Stimulation in Rehabilitation for Cats with Partial Traumatic Brachial Plexus Injury: A Pilot Study on Domestic Cats in Portugal". Animals (2024): https://www.mdpi.com/2076-2615/14/2/323.
    10.3390/ani14020323
  9. Assunção-Silva, Rita C; Pinho, Andreia; Cibrão, Jorge R; Pereira, Inês M; Monteiro, Susana; Silva, Nuno A; Campos, Jonas; et al. "Adipose tissue derived stem cell secretome induces motor and histological gains after complete spinal cord injury in Xenopus laevis and mice". Journal of Tissue Engineering 15 (2024): http://dx.doi.org/10.1177/20417314231203824.
    Acesso aberto • No prelo • 10.1177/20417314231203824
  10. Lentilhas-Graça, J.; Santos, D.J.; Afonso, J.; Monteiro, A.; Pinho, A.G.; Mendes, V.M.; Dias, M.S.; et al. "The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol". Frontiers in Immunology 15 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85186567972&partnerID=MN8TOARS.
    10.3389/fimmu.2024.1354479
  11. Pinho, T.S.; Cibrão, J.R.; Silva, D.; Barata-Antunes, S.; Campos, J.; Afonso, J.L.; Sampaio-Marques, B.; et al. "In vitro neuronal and glial response to magnetically stimulated piezoelectric poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)/cobalt ferrite (CFO) microspheres". Biomaterials Advances 159 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85185200984&partnerID=MN8TOARS.
    10.1016/j.bioadv.2024.213798
  12. Marques, C.R.; Campos, J.; Sampaio-Marques, B.; Antunes, F.F.; dos Santos Cunha, R.M.; Silva, D.; Barata-Antunes, S.; et al. "Secretome of bone marrow mesenchymal stromal cells cultured in a dynamic system induces neuroprotection and modulates microglial responsiveness in an a-synuclein overexpression rat model". Cytotherapy (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85187579321&partnerID=MN8TOARS.
    10.1016/j.jcyt.2024.02.008
  13. Martins-Macedo, J.; Araújo, B.; Anjo, S.I.; Silveira-Rosa, T.; Patrício, P.; Alves, N.D.; Silva, J.M.; et al. "Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation". Molecular Psychiatry (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85186885732&partnerID=MN8TOARS.
    10.1038/s41380-024-02490-z
  14. M. Moura, Maria; Andreia Monteiro; Salgado, António J.; Silva, Nuno A.; Monteiro, Susana. Autor correspondente: Monteiro, Susana. "Disrupted autonomic pathways in spinal cord injury: Implications for the immune regulation". Neurobiology of Disease (2024): https://www.sciencedirect.com/science/article/pii/S0969996124000998.
    Publicado • https://doi.org/10.1016/j.nbd.2024.106500
  15. Bruna Lopes; André Coelho; Rui Alvites; Ana Catarina Sousa; Patrícia Sousa; Alícia Moreira; Luís Atayde; et al. "Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment". Regenerative Medicine (2023): https://doi.org/10.2217/rme-2023-0102.
    10.2217/rme-2023-0102
  16. Silva, Deolinda; Schirmer, Lucas; Pinho, Tiffany S.; Atallah, Passant; Cibrão, Jorge R.; Lima, Rui; Afonso, João; et al. "Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star-Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model". Advanced Healthcare Materials (2023): 2202803. http://dx.doi.org/10.1002/adhm.202202803.
    10.1002/adhm.202202803
  17. de Sousa, Nídia; Pinho, Andreia G.; Monteiro, Susana; Liberato, Valentina; Santos, Diogo J.; Campos, Jonas; Cibrão, Jorge R.; et al. "Acute baclofen administration promotes functional recovery after spinal cord injury". The Spine Journal 23 3 (2023): 379-391. http://dx.doi.org/10.1016/j.spinee.2022.09.007.
    10.1016/j.spinee.2022.09.007
  18. de Sousa, Nidia; Robledo, Diego; González-Llera, Laura; Pinho, Andreia G.; Santos, Diogo J.; Monteiro, Susana; Campos, Jonas; et al. "Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury". Data in Brief 46 (2023): 108809. http://dx.doi.org/10.1016/j.dib.2022.108809.
    10.1016/j.dib.2022.108809
  19. Cen, Wanjing; Umrath, Felix; Salgado, António José; Reinert, Siegmar; Alexander, Dorothea. "Secretomes derived from osteogenically differentiated jaw periosteal cells inhibit phenotypic and functional maturation of CD14+ monocyte-derived dendritic cells". Frontiers in Immunology 13 (2023): http://dx.doi.org/10.3389/fimmu.2022.1024509.
    10.3389/fimmu.2022.1024509
  20. Maciel, Patrícia; Correia, JoanaSofia; Duarte-Silva, Sara; Salgado, AntónioJosé. "Cell-based therapeutic strategies for treatment of spinocerebellar ataxias: an update". Neural Regeneration Research 18 6 (2023): 1203. http://dx.doi.org/10.4103/1673-5374.355981.
    10.4103/1673-5374.355981
  21. Mendes-Pinheiro, B.; Campos, J.; Marote, A.; Soares-Cunha, C.; Nickels, S.L.; Monzel, A.S.; Cibrão, J.R.; et al. "Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration". Cells 12 21 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85176403976&partnerID=MN8TOARS.
    10.3390/cells12212565
  22. Pischiutta, F.; Cavaleiro, H.; Caruso, E.; Tribuzio, F.; Di Marzo, N.; Moro, F.; Kobeissy, F.; et al. "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment". Frontiers in Cellular Neuroscience 17 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85166397365&partnerID=MN8TOARS.
    10.3389/fncel.2023.1217987
  23. Silva-Pedrosa, R.; Campos, J.; Fernandes, A.M.; Silva, M.; Calçada, C.; Marote, A.; Martinho, O.; et al. "Cerebral Malaria Model Applying Human Brain Organoids". Cells 12 7 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85152325895&partnerID=MN8TOARS.
    10.3390/cells12070984
  24. Pinho, A.G.; Monteiro, A.; Fernandes, S.; de Sousa, N.; Salgado, A.J.; Silva, N.A.; Monteiro, S.. "The Central Nervous System Source Modulates Microglia Function and Morphology In Vitro". International Journal of Molecular Sciences 24 9 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85159317681&partnerID=MN8TOARS.
    10.3390/ijms24097685
  25. Silva-Pedrosa, R.; Salgado, A.J.; Ferreira, P.E.. "Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems". Cells 12 6 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85151107974&partnerID=MN8TOARS.
    10.3390/cells12060930
  26. Marques, C.R.; Fuzeta, M.D.A.; dos Santos Cunha, R.M.; Pereira-Sousa, J.; Silva, D.; Campos, J.; Teixeira-Castro, A.; et al. "Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems". Biomedicines 11 5 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85160806316&partnerID=MN8TOARS.
    10.3390/biomedicines11051240
  27. Sousa, C.S.; Lima, R.; Cibrão, J.R.; Gomes, E.D.; Fernandes, L.S.; Pinho, T.S.; Silva, D.; et al. "Pre-Clinical Assessment of Roflumilast Therapy in a Thoracic Model of Spinal Cord Injury". Pharmaceutics 15 5 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85160415912&partnerID=MN8TOARS.
    10.3390/pharmaceutics15051556
  28. Lima, Rui; Monteiro, Andreia; Salgado, António J.; Monteiro, Susana; Silva, Nuno A.. "Pathophysiology and Therapeutic Approaches for Spinal Cord Injury". International Journal of Molecular Sciences 23 22 (2022): 13833. http://dx.doi.org/10.3390/ijms232213833.
    10.3390/ijms232213833
  29. Pischiutta, Francesca; Caruso, Enrico; Cavaleiro, Helena; Salgado, Antonio J.; Loane, David J.; Zanier, Elisa R.. "Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action". Experimental Neurology 357 (2022): 114199. http://dx.doi.org/10.1016/j.expneurol.2022.114199.
    10.1016/j.expneurol.2022.114199
  30. Fernandes, Aline M.; Campos, Jonas; Silva, Deolinda; Barata Antunes, Sandra; Lima, Rui; Coelho, Claudio; Marote, Ana M.; et al. "Cerebral Organoids to Study Central Mechanisms of Pain: The Effect of Stem Cell Secretome on Opioid Receptors and Neuroplasticity". Stem Cells and Development 31 19-20 (2022): 641-657. http://dx.doi.org/10.1089/scd.2022.0116.
    10.1089/scd.2022.0116
  31. Marote, Ana; Santos, Diogo; Mendes-Pinheiro, Bárbara; Serre-Miranda, Cláudia; Anjo, Sandra I.; Vieira, Joana; Ferreira-Antunes, Filipa; et al. "Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture". Stem Cell Reviews and Reports 19 1 (2022): 248-263. http://dx.doi.org/10.1007/s12015-022-10453-6.
    10.1007/s12015-022-10453-6
  32. Pinho, Tiffany S.; Silva, Deolinda; Ribeiro, Jorge Cibrão; Marote, Ana; Lima, Rui; Batista, Salete J.; Melo, Rita; et al. "Enhanced neuronal differentiation by dynamic piezoelectric stimulation". Journal of Biomedical Materials Research Part A 111 1 (2022): 35-44. http://dx.doi.org/10.1002/jbm.a.37443.
    10.1002/jbm.a.37443
  33. Barbosa, Marta; Santos, Marta; de Sousa, Nídia; Duarte-Silva, Sara; Vaz, Ana Rita; Salgado, António J.; Brites, Dora. "Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice". Biomedicines 10 9 (2022): 2120. http://dx.doi.org/10.3390/biomedicines10092120.
    10.3390/biomedicines10092120
  34. Teixeira, FábioG; Silva, RitaCaridade; Domingues, Helena Sofia; Salgado, António J.. "From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson’s disease?". Neural Regeneration Research 17 5 (2022): 933. http://dx.doi.org/10.4103/1673-5374.324827.
    10.4103/1673-5374.324827
  35. Campos, Jonas; Silva, Nuno A; Salgado, António J. "Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms". Nutrition Reviews 80 5 (2021): 1206-1221. http://dx.doi.org/10.1093/nutrit/nuab068.
    Publicado • 10.1093/nutrit/nuab068
  36. Correia, J.S.; Neves-Carvalho, A.; Mendes-Pinheiro, B.; Pires, J.; Teixeira, F.G.; Lima, R.; Monteiro, S.; et al. "Preclinical assessment of mesenchymal-stem-cell-based therapies in spinocerebellar ataxia type 3". Biomedicines 9 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85120072858&partnerID=MN8TOARS.
    10.3390/biomedicines9121754
  37. Martins-Macedo, J.; Salgado, A.J.; Gomes, E.D.; Pinto, L.. "Adult brain cytogenesis in the context of mood disorders: From neurogenesis to the emergent role of gliogenesis". Neuroscience and Biobehavioral Reviews 131 (2021): 411-428. http://www.scopus.com/inward/record.url?eid=2-s2.0-85117139413&partnerID=MN8TOARS.
    10.1016/j.neubiorev.2021.09.030
  38. Mendes-Pinheiro, B.; Soares-Cunha, C.; Marote, A.; Loureiro-Campos, E.; Campos, J.; Barata-Antunes, S.; Monteiro-Fernandes, D.; et al. "Unilateral intrastriatal 6-hydroxydopamine lesion in mice: a closer look into non-motor phenotype and glial response". International Journal of Molecular Sciences 22 21 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85117912045&partnerID=MN8TOARS.
    10.3390/ijms222111530
  39. Pischiutta, F.; Caruso, E.; Lugo, A.; Cavaleiro, H.; Stocchetti, N.; Citerio, G.; Salgado, A.; Gallus, S.; Zanier, E.R.. "Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury". npj Regenerative Medicine 6 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118457613&partnerID=MN8TOARS.
    10.1038/s41536-021-00182-8
Pré-impressão
  1. Moura, Maria; Miranda, Alice; Campos, Jonas; Pinho, Andreia G.; Rito-Fernandes, Sara; Soares-Cunha, Carina; Salgado, António J.; Silva, Nuno; Monteiro, Susana. Autor correspondente: Monteiro, Susana. "Macro- and Microanatomy of Spleen-Innervating Sympathetic Neurons". 2024. http://dx.doi.org/10.2139/ssrn.4835357.
    10.2139/ssrn.4835357

Outros

Outra produção
  1. Glial-Restricted Precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation. 2023. Pinto, L.; Macedo, J.; Araújo, B.; Anjo, S.; Silveira-Rosa, T.; Patrício, P.; Teixeira, F.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85167551781&partnerID=MN8TOARS.
    10.21203/rs.3.rs-2747462/v1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2025 Stem Cell Secretome as a Molecular Therapy in Parkinson’s Disease Regenerative Medicine 5th Sign Conference
(Basel, Suiça)
2025 Stem Cell Secretome as a Bio-Molecular Therapeutics in Parkinson’s Disease Regenerative Medicine Stem Cell Therapy in Neurodegenerative Disorders and Spinal Cord Injury webinar - FENS Committee for Higher Education and Training
2025 Modulatory Activity of Stem Cells Secretome in the Central Nervous System CURAM - University of Galway
(Galway, Irlanda)
2024/05/26 Stem cell Secretome based Approaches in Central Nervous System Regenerative Medicine: From in vitro Studies to in vivo Pre-Clinical Studies, UNIARP, May 2024, Caçador, Brazil
2024/04/24 Stem Cell Secretome based Strategies in SCI Regenerative Medicine, Rice University, April 2024, Houston, USA
2024 António Salgado, Cell Secretome and Biodegradable Biomaterials for CNS Regenerative Medicine: Insights on Spinal Cord Injury and Parkinson’s Disease, September 2024, Braga, Portugal
2024 Combinatory use of Cell Secretome and  Biodegradable Biomaterials for CNS Regenerative Medicine: Insights on Spinal Cord Injury and Parkinson’s Disease Future Materials
(Athens, Grécia)
2023/11 Stem Cells Secretome and Biomaterials based Strategies in SCI Regenerative Medicine FENS Winter School
(Faro, Portugal)
2023/10 Cerebral Organoids to Study Centralç Mechanisms of Pain: The effect of Stem Cell Secretome on Opiod Receptors and Neuroplasticity iFATS 2023
(Washington D.C. , Estados Unidos)
2023/10 Stem Cell Secretome based Approaches in Parkinson's Disease Regenerative Medicine New Therapies-One Health
(Porto, Portugal)
2023/09 Innovative Approaches using Cryopreserved Stem Cells Secretome for CNS Regeneration HEALTH-UNORTE
(Guimarães, Portugal)
2023/06 Stem Cells Secretome as an Emerging Tool for CNS Regeneration ISCT - 2023
(Paris, França)
2023/06 Impact of Stem Cells Secretome in Injury and Disease of the CNS Biotech Health - 2023
(Porto, Portugal)
2023/05 New Avenues for CNS Regeneration using Stem Cells Secretome
Universidade de Trás os Montes e Alto Douro (Vila Real, Portugal)
2023/05 Baclofen as a Potential Treatment to Promote Recovery from Spinal Cord Injury Wings for Life Scientific Meeting
(Salzburg, Áustria)
2023/04 Stem Cells Secretome as a Tool to Tackle Injury and Degeneration in the CNS
Instituto Superior Técnico (Oeiras, Portugal)
2022 Unveiling the Multiple Roles of Stem Cells Secretome in Nerve Regeneration TERMIS-EU 2022
(Krakow, Polónia)
2022 Exploring New Therapeutic Approaches for CNS Repair: Pre-Clinical Studies ISPRM 2022
(Lisbon, Portugal)
2022 Stem Cells Secretome: Na Emerging Tool in CNS Regenerative Medicine ESPRAS 2022
(Porto, Portugal)
2022 Stem Cells Secretome as a Regenerative Tool for Central Nervous System Regenerative Medicine Small New World
(Salzburg, Áustria)
2022 Stem Cells Secretome in CNS Regenerative Medicine: Pre-Clinical Studies and Future Trends CEDOC- Nova Medical School
(Lisbon, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024 - Atual Exploring the Role of Stem cells Secretomein the Modulation of Proteostasis in Parkinson’s Disease
Orientador de Filipa Antunes
 Doctoral Program in Biomedical and Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024 - Atual Braking Barriers: A Multidisciplinary Therapeutic Approach for Spinal Cord Injury Repair
Coorientador de Marta Ferreira
 Doctoral Program in Biomedical and Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024 - Atual Modulating Mesenchymal Stem Cells to Maximize its Therapeutic Efficacy in Ischemic Stroke
Coorientador de Susana Ferreira
 Doctoral Program in Biomedicine (Doutoramento)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2024 - Atual Optimizing the Cryopreservation of Induced Mesenchymal Stem Cell-Like Cells Secretome: Exploring the Efficacy of Lyophilization
Coorientador de Carla Pereira
 Masters Biomedicine (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024 - Atual Priming Mesenchymal Stem Cells (MSCs) as a therapeutic strategy for nervous system degeneration: insights from in vitro models
Coorientador de Bárbara Pereira
 Masters in Biomedicine (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024 - Atual Optimization of the Delivery Routes of Mesenchymal Stem Cells Secretome in a Rodent Animal Model of Parkinson’s Disease
Orientador de Maria Almeida
 Masters in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra, Portugal
2024 - Atual Electroactive Secretome-Hydrogel Biomaterials for Spinal Cord Injury Regeneration
Orientador de Melyssa Carvalho
 Masters in Biomedicine (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/09/01 - Atual Impact of te Secretome of Induced Mesenchymal Stem Cells as a Therapeutic Option for the Treatment of Parkinson’s Disease
Orientador de 29- Alessander Ledeyecker
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023 - Atual Exploring the Role of Mesenchymal Stem Cells Secretome in Peripheral Nerve Regeneration: One Health Perspective
Coorientador de Bruna Lopes
 Doctoral Program in Veterinary Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023 - Atual The Therapeutic Potential of Mesenchymal Stem Cell Secretome-Derived DJ-1 in Parkinson’s Disease
Orientador de Anabela Moreira
 Doctoral Program in Health Sciences
Universidade do Minho Escola de Medicina, Portugal
2023 - Atual Biocompatible and Durable Fibrous Composites based on Bacterial Nanocellulose and Lignin for the Treatment of Microsvascular Decompression
Coorientador de Cátia Alves
 Doctoral Program in Textile Engineering (Doutoramento)
Universidade do Minho Escola de Engenharia, Portugal
2022 - Atual Genetic Engineering of the CD81 Large Extracellular Loop for Targeted Delivery of MSC Derived EVs for Spinal Cord Injury in Companion Dogs
Orientador de Diogo Santos
 Doctoral Program in Biomedical and Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2021 - Atual Reestablishment of the Neurovascular Unit as a Novel Approach to Induce Regeneration of the Injured Spinal Cord
Orientador de João Afonso
 Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2021 - 2025 Promoting Spinal Cord Injury Regeneration through the Combination of Stem Cells Secretome and the Omeha-3 Fatty Acid Docosahexaenoic Acid
Orientador
 Doctoral Program in Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2020 - 2025 Development and Manufacturing of Fibrinogen-Depleted Human Platelet Lystaes for Cell-based Clinical Therapies
Orientador
 Doctoral Program in Applied Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2023 - 2024 Multi-omics analysis of the secretome effect in a spinal cord injury in vitro system
Orientador de Ana Teresa Sousa
 Masters in Biomedicine (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2024 Secretome Loaded Piezoelectric Hydrogels as Advanced Biomaterials for Spinal Cord Injury Repair
Orientador
 Doctoral Program in Applied Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2019 - 2024 Combinatory use of Gellan Gum Hydrogels and Mesenchymal Stem Cells to Promote Traumatic Brain Injury Regeneration
Orientador
 Doctoral Program in Applied Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022/03/10 - 2022/03/11 12th International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies (2022/03/10 - 2022/03/11)
Conferência (Presidente da Comissão Organizadora)

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023 MicroRNAs-enriched exosomes as a new therapy for Parkinson’s disease
Arguente
 Marta Esteves (Doutoramento)
Universidade da Beira Interior, Portugal
2023 DEVELOPMENT OF REGENERATIVE MEDICINE THERAPIES BASED ON PLATELET-DERIVED PRODUCTS FOR THE TREATMENT APPROACHES OF DOGS AND CATS
Arguente principal
 Carla Soares (Doutoramento)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2023 Provas de Agregação/Habilitation
Vogal
 Agostinho Carvalho (Agregação)
Universidade do Minho, Portugal
2023 Provas de Agregação
Vogal
 Fernanda Marques (Agregação)
Universidade do Minho, Portugal
2022 Identifying Molecules and Mechanisms Enhancing Axon Growth: Acomys cahirinus as a model of mammalian regeneration
Arguente
 Joana Rodrigues (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 The Impact of Culture Environment on the Composition and Function of Mesenchymal Stem Cell Derived EVs
Arguente principal
 Jolene Phelps (Doutoramento)
University of Calgary, Canadá
2022 Underlying Role of Glycation in the Pathogenesis of Parkinson’s Disease
Arguente principal
 Ana Chegão (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 Extracellular Vesicles: From Brain Communication to Therapeutic Delivery
Arguente principal
 António Ramos (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022 Immunomodulatory Effect of Different Stimuli in Mesenchymal Stem Cells
Arguente principal
 Diana Gonçalves (Doutoramento)
Universidade de Aveiro, Portugal
2021/11 The role of Ube3a in neuronal development
Arguente principal
 Carlos Resende (Mestrado)
Universidade de Aveiro, Portugal
2021 Provas de Agregação - Ramo Ciências da Saúde - Biomedicina Gabriela silva (Agregação)
Universidade Nova de Lisboa, Portugal
2021 Hydrogels derived from human chorionic membrane as an innovative platform for 3D cell culture
Arguente principal
 Elisa Martins (Mestrado)
Universidade de Aveiro, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2024/10/01 - 2024/11/01 European Comission - PREMSTEM (mid term reporta evaluator)
Avaliador
2024/05/01 - 2024/07/31 European Research Council (grant remote evaluator) European Research Council
2024/04/01 - 2024/05/31 European Innovation Council (evaluation of grants)
Avaliador
 European Innovation Council
2024/01/01 - 2024/04/30 Fondazione Regionale per la Ricerca Biomedica (evaluation of grant proposals)
Avaliador
2023 - 2023 Fonds National de la Recherche Luxembourg (evaluation of grant proposals)
2023 - 2023 Merian Fund Brazil (evaluation of grant proposals)
2023 - 2023 National Science Center – Poland (evaluation of grant proposals)
2023 - 2023 Quatar National Research Fund
2022 - 2022 Regional Foundation for Biomedical Research (Lombardia, Italy)
Membro
2022 - 2022 Portuguese Foundation for Science and Technology (FCT – evaluation of proposals for pre doctoral fellowships – Biotechnology and Bioengineering);
2022 - 2022 National Swiss Science Foundation (evaluation of grant proposals)
2020 - 2020 National Swiss Science Foundation (evaluation of grant proposals)
Avaliador
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2024/10/01 - Atual President, Center of Health Innovation
Presidente / Vice-presidente
2022 - Atual Vice-Dean for Research
Membro
 Universidade do Minho Escola de Medicina, Portugal
2021 - 2022 Elected member for the general council of the School of Medicine, University of Minho
Membro
 Universidade do Minho Escola de Medicina, Portugal
Distinções

Prémio

2023 University of Minho Prize for Scientific Merit
Universidade do Minho, Portugal
2023 Grunenthal Award for Basic Research in Pain
Fundação Grünenthal, Portugal
2021 Prize Melo e Castro for Spinal Cord Injury Research
Santa Casa Misericórida Lisboa, Portugal