Teresa Santos-Silva (791D-CFC2-D35A)

Curriculum Vitae

Teresa Santos-Silva

Teresa Santos-Silva graduated in Chemistry at NOVA FCT and obtained a PhD in Structural Biology in 2006. She is currently Assistant Professor of Biochemistry at NOVA FCT and a structural biology researcher specializing in protein crystallography and metalloenzymes. Her research focuses on protein–ligand interactions with biomedical and environmental relevance, including molybdenum-containing enzymes, biofilm-related proteins, and peptidoglycan biosynthesis. She has contributed to the structural characterization of metal-based compounds interacting with biological systems and to the understanding of ligand binding mechanisms using X-ray crystallography, SAXS, and complementary biophysical techniques. She has authored over 60 peer-reviewed publications and received the Clara Immerwahr Award (2014). She has also served as main arguer in PhD examinations in Biochemistry at national and international universities. Since 2009, she has supervised postdoctoral researchers, PhD and MSc students, contributing to the training of new scientists. She leads funded research projects, collaborates internationally, and serves on scientific evaluation panels. In parallel, her work has increasingly expanded into education, pedagogical innovation, and researcher development. Since 2024, she serves as Associate Dean for Pedagogical Innovation and Well-being at NOVA FCT. She founded the Community of Practice for Pedagogical Innovation, engaging over 240 faculty and researchers, and co-organized the Pedagogical Innovation Days in 2025 and 2026, bringing together over 100 participants. She also launched the first call for Pedagogical Innovation Projects at NOVA FCT, fostering innovation among faculty and researchers. In 2025, she created an innovative Mentorship Program, in collaboration with the Careers and Psychological Support Offices, which has already engaged over 420 participants. She also leads a EUTOPIA Connected Community focused on education, employability, and the development of PhD researchers. She has a growing interest in the role of generative AI in education, actively contributing to discussions, roundtables, and training initiatives on the topic. She authored an opinion article in Executive Digest and regularly participates in reflection sessions on the impact of AI in teaching and learning. This interest is reflected in her pedagogical practice, where she integrates AI tools into undergraduate and MSc teaching and promotes critical engagement with these technologies. At the doctoral level, she organizes workshops to support PhD researchers in the ethical and effective use of AI in their academic and professional development. Her contributions extend to academic service and institutional leadership. She served as evaluator of pedagogical innovation projects at Egas Moniz, is a member of Working Group 2 of a COST Cross-Cutting Activity, and has been nominated as NOVA representative to the Faculty and Staff Council of the EUTOPIA Alliance. Through these roles, together with her workshops on career development, communication, and pedagogical innovation, she bridges science, education, and personal development.

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Identificação

Identificação pessoal

Nome completo: Teresa Santos-Silva

Nomes de citação

Santos-Silva, Teresa

Identificadores de autor

Ciência ID: 791D-CFC2-D35A
ORCID iD: 0000-0003-3060-8378

Domínios de atuação

Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2023/09/01 - 2024/09/01 Concluído	Post-graduation in Pedagogy in Higher Education (Pós-Graduação) Universidade de Lisboa Instituto da Educação, Portugal
2022/05/25 Concluído	Neurolinguistic Coaching (92h) (Especialização pós-licenciatura) Instituto Internacional de Programação Neurolinguística , Portugal
2021/05/01 Concluído	Master in Neurolinguistic Programming (130h) (Especialização pós-licenciatura) Instituto Internacional de Programação Neurolinguística , Portugal
2006/12/13 Concluído	Strucutral Biology (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Structural characterization of heme and non-heme iron containing proteins" (TESE/DISSERTAÇÃO)	Unanimously approved
2001 Concluído	Química Aplicada (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Purificação de dois citocromos de bacterias redutoras de sulfato" (TESE/DISSERTAÇÃO)	15/20

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2014 - 2018/05/31	Investigador principal (carreira) (Investigação)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2014	Investigador visitante (Investigação)	Universität Potsdam Institut für Biochemie und Biologie, Alemanha

2009 - 2014	Investigador Auxiliar (carreira) (Investigação)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

2007 - 2009	Pós-doutorado (Investigação)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2018/06/01 - Atual	Professor Auxiliar (Docente Universitário)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2004 - 2007	Professor Adjunto Convidado (Docente Ensino Superior Politécnico)	Universiddade Católica Escola de Tecnologia e Gestão Industrial, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2024/03/01 - Atual	Associate Dean for Pedagogical Innovation and Well-Being	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Projetos

Bolsa

	Designação	Financiadores
2023 - Atual	Bilateral agreement Portugal - Germany: Unveiling the catalytic mechanism of Mo enzymes: Towards efficient carbon dioxide fixation and arsenic detoxification. 2022.15290.CBM Investigador	Em curso
2022 - Atual	Bilateral agreement Portugal-France: Biochemical, functional and structural studies of the human norepinephrine transporter. 2021.09576.CBM Investigador	Em curso
2022 - Atual	Twinning Action – GLYCOTwinning: Building Networks to Excel in Glycosciences HORIZON-WIDERA-2021-101079417 Investigador	Em curso
2018 - 2022	StaphOUT - Fighting Staphylococcus aureus - Peptidoglycan amidation as a new target PTDC/BIA-MIC/31645/2017 Investigador REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2022	Bacterial ABC-type Multitask Energizers: one ATPase fits all? PTDC/BIA-MIC/30696/2017 Investigador REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Concluído
2016 - 2019	Carbon monoxide guided shuttles (COGSs) to fight Rheumatoid Arthritis PTDC/QEQ-MED/1902/2014 Investigador responsável REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016 - 2019	REDUCTION OF CO2 FOR SUSTAINABLE BIOFUEL PRODUCTION PTDC/BBB-EBB/2723/2014 Investigador Fundação para a Ciência e a Tecnologia, Portugal	Concluído
2016 - 2019	ALDEHYDE OXIDASES IN DRUG METABOLISM AND BIOCATALYSIS: SEARCHING FOR THE SUBSTRATE SPECIFICITY AND CATALYTIC MECHANISM PTDC/BBB-BEP/1185/2014 Investigador Fundação para a Ciência e a Tecnologia, Portugal	Concluído
2016 - 2019	Carbon monoxide guided shuttles (COGSs) to fight Rheumatoid Arthritis PTDC/QEQ-MED/1902/2014	Fundação para a Ciência e a Tecnologia
2013/07 - 2016/06	Modern Structural Biology: Resources for the advancement of in-house X-ray Crystallography 125363 Provided by PTCRIS: 125363	Fundação para a Ciência e a Tecnologia, I.P.
2013 - 2016	Modern Structural Biology: Resources for the advancement of in-house X-ray Crystallography RECI/BBB-BEP/0124/2012 Investigador Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/01 - 2015/12	ENZYMATIC CATALYSIS - seeking a global picture 128544 Provided by PTCRIS: 128544	Fundação para a Ciência e a Tecnologia, I.P.
2012/03 - 2015/02	Protein interaction with CO Releasing Molecules (CORM) 117799 Provided by PTCRIS: 117799	Fundação para a Ciência e a Tecnologia, I.P.
2012/02 - 2015/01	Nitric Oxide Synthase targeting with Re(I)/99mTc(I)-complexes containing L-Arg derivatives: A structure-activity study 121752 Provided by PTCRIS: 121752	Fundação para a Ciência e a Tecnologia, I.P.
2012/02 - 2015/01	Mammalian and Bacterial Aldehyde Oxidases: Structure, mechanism and insights into cofactor binding and protein maturation Provided by PTCRIS: 118377 118377	Fundação para a Ciência e a Tecnologia, I.P.
2013 - 2015	ENZYMATIC CATALYSIS - seeking a global picture EXCL/QEQ-COM/0394/2012 Investigador Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013 - 2015	Studies of Molybdenum-containing enzymes DAAD-441.00 Investigador responsável Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universität Potsdam Institut für Biochemie und Biologie, Alemanha	Concluído
2012 - 2015	Protein interaction with CO Releasing Molecules (CORM) PTDC/QUI-BIQ/117799/2010 Investigador responsável Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2014 - 2014	Mammalian and Bacterial Aldehyde Oxidases: Structure, mechanism and insights into cofactor binding and protein maturation PTDC/BIA-PRO/118377/2010 Investigador responsável REQUIMTE, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009/01 - 2012/09	Production of a stable form of human phenylalanine hydroxylase: towards the 3D structure determination. 64023 Provided by PTCRIS: 64023	Fundação para a Ciência e a Tecnologia, I.P.
2009/01 - 2011/12	Structure and function of novel carbohydrate-binding modules and cohesin-dockerin protein complexes from Clostridium thermocellum 69732 Provided by PTCRIS: 69732	Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2011/06	Xanthine Oxidase-Related Enzymes: Structure, Function and Specificity 64733 Provided by PTCRIS: 64733	Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2008/11	Structural and Functional Characterization of Nitrate Reductases and Formate Dehydrogenases 82151 Provided by PTCRIS: 82151	Fundação para a Ciência e a Tecnologia, I.P.
2005/05 - 2007/06	Structural and Functional Characterization of Nitrate Reductases and Formate Dehydrogenases 57641 Provided by PTCRIS: 57641	Fundação para a Ciência e a Tecnologia, I.P.

Projeto

	Designação	Financiadores
2026/01/01 - Atual	The Phosphatase PtpA as a Suitable Target to Fight Tuberculosis – A Structure-based Drug Design Approach 2024.15885.PEX Bolseiro de Integração na Investigação
2025/06/01 - 2026/12/31	SEEDS for Tomorrow: Supporting Education, Employability, and Development of PhD candidateS EUTOPIA_CC_R3_SEEDS Investigador responsável Universidade Nova de Lisboa, Portugal	Em curso

Produções

Publicações

Artigo em conferência	Sequeira, F.; Nogueira, R.; Bilro, L.; Santos-Silva, T.. "Coating of modified plastic optical fibers with proteins for chemical sensing and biosensing – preliminary studies". 2019. 10.1117/12.2522347
Artigo em revista	Rivas MG; Correia Cordeiro RS; Nair RR; Albuquerque LJC; Correia MAS; Panjkovich A; Svergun DI; Santos-Silva T. "Studies of the structural properties and stability of the molybdenum transport protein ModA from Oleidesulfovibrio alaskensis G20 upon metal binding.". Archives of biochemistry and biophysics (2025): http://europepmc.org/abstract/med/41130348. 10.1016/j.abb.2025.110642 Paquete-Ferreira, João; Freire, Filipe; Fernandes, Henrique S.; Muthukumaran, Jayaraman; Ramos, João; Bryton, Joana; Panjkovich, Alejandro; et al. "Structural insights of an LCP protein–LytR–from Streptococcus dysgalactiae subs. dysgalactiae through biophysical and in silico methods". Frontiers in Chemistry 12 (2024): https://doi.org/10.3389/fchem.2024.1379914. 10.3389/fchem.2024.1379914 Engrola F; Correia MAS; Watson C; Romão CC; Veiros LF; Romão MJ; Santos-Silva T; Santini JM. "Arsenite oxidase in complex with antimonite and arsenite oxyanions - insights into the catalytic mechanism.". The Journal of biological chemistry (2023): http://europepmc.org/abstract/med/37442232. 10.1016/j.jbc.2023.105036 Barroca-Ferreira, J; Gonçalves, AM; Santos, MFA; Santos-Silva, T; Maia, CJ; Passarinha, LA. "A chromatographic network for the purification of detergent-solubilized six-transmembrane epithelial antigen of the prostate 1 from Komagataella pastoris mini-bioreactor lysates". Journal of Chromatography A 1685 (2022): 463576. http://dx.doi.org/10.1016/j.chroma.2022.463576. 10.1016/j.chroma.2022.463576 Santos MFA; Sciortino G; Correia I; Fernandes ACP; Santos-Silva T; Pisanu F; Garribba E; Pessoa JC. "Binding of VIVO2+, VIVOL+, VIVOL2 and VVO2L moieties to proteins: X-ray/theoretical characterization and biological implications.". Chemistry (Weinheim an der Bergstrasse, Germany) (2022): http://europepmc.org/abstract/med/35486702. 10.1002/chem.202200105 Barroca-Ferreira J; Cruz-Vicente P; Santos MFA; Rocha SM; Santos-Silva T; Maia CJ; Passarinha LA. "Enhanced Stability of Detergent-Free Human Native STEAP1 Protein from Neoplastic Prostate Cancer Cells upon an Innovative Isolation Procedure.". International journal of molecular sciences (2021): http://europepmc.org/abstract/med/34576175. 10.3390/ijms221810012 Mota C; Diniz A; Coelho C; Santos-Silva T; Esmaeeli M; Leimkühler S; Cabrita EJ; Marcelo F; Romão MJ. "Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.". Journal of medicinal chemistry (2021): http://europepmc.org/abstract/med/34415167. 10.1021/acs.jmedchem.1c01125 Alves-Barroco C; Paquete-Ferreira J; Santos-Silva T; Fernandes AR. "Singularities of Pyogenic Streptococcal Biofilms - From Formation to Health Implication.". Frontiers in microbiology (2020): http://europepmc.org/abstract/med/33424785. 10.3389/fmicb.2020.584947 Leisico F; Godinho LM; Gonçalves IC; Silva SP; Carneiro B; Romão MJ; Santos-Silva T; de Sá-Nogueira I. "Multitask ATPases (NBDs) of bacterial ABC importers type I and their interspecies exchangeability.". Scientific reports (2020): http://europepmc.org/abstract/med/33177617. 10.1038/s41598-020-76444-0 Chakradhara Rao S. Uppugunduri; Jayaraman Muthukumaran; Shannon Robin; Teresa Santos-Silva; Marc Ansari. "In silico and in vitro investigations on the protein–protein interactions of glutathione S-transferases with mitogen-activated protein kinase 8 and apoptosis signal-regulating kinase 1". Journal of Biomolecular Structure and Dynamics (2020): https://doi.org/10.1080/07391102.2020.1827036. 10.1080/07391102.2020.1827036 Fernandes, A.R.; Mendonça-Martins, I.; Santos, M.F.A.; Raposo, L.R.; Mendes, R.; Marques, J.; Romão, C.C.; et al. "Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules". ACS Biomaterials Science and Engineering 6 2 (2020): 1090-1101. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079071744&partnerID=MN8TOARS. 10.1021/acsbiomaterials.9b01936 Oliveira, A.R.; Mota, C.; Mourato, C.; Domingos, R.M.; Santos, M.F.A.; Gesto, D.; Guigliarelli, B.; et al. "Toward the Mechanistic Understanding of Enzymatic CO2 Reduction". ACS Catalysis 10 6 (2020): 3844-3856. http://www.scopus.com/inward/record.url?eid=2-s2.0-85082073064&partnerID=MN8TOARS. 10.1021/acscatal.0c00086 Alves-Barroco, C.; Roma-Rodrigues, C.; Balasubramanian, N.; Guimarães, M.A.; Ferreira-Carvalho, B.T.; Muthukumaran, J.; Nunes, D.; et al. "Biofilm development and computational screening for new putative inhibitors of a homolog of the regulatory protein BrpA in Streptococcus dysgalactiae subsp. dysgalactiae". International Journal of Medical Microbiology 309 3-4 (2019): 169-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061783871&partnerID=MN8TOARS. 10.1016/j.ijmm.2019.02.001 Coelho, C.; Muthukumaran, J.; Santos-Silva, T.; João Romão, M.. "Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio-informatics study". Pharmacology Research and Perspectives 7 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075577847&partnerID=MN8TOARS. 10.1002/prp2.538 Ramos, J.; Muthukumaran, J.; Freire, F.; Paquete-Ferreira, J.; Otrelo-Cardoso, A.R.; Svergun, D.; Panjkovich, A.; Santos-Silva, T.. "Shedding light on the interaction of human anti-apoptotic Bcl-2 protein with ligands through biophysical and in silico studies". International Journal of Molecular Sciences 20 4 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85061864351&partnerID=MN8TOARS. 10.3390/ijms20040860 Mota, C.; Esmaeeli, M.; Coelho, C.; Santos-Silva, T.; Wolff, M.; Foti, A.; Leimkühler, S.; Romão, M.J.. "Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms". FEBS Open Bio 9 5 (2019): 925-934. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065033277&partnerID=MN8TOARS. 10.1002/2211-5463.12617 Cordeiro M; Otrelo-Cardoso AR; Svergun DI; Konarev PV; Lima JC; Santos-Silva T; Baptista PV. "Optical and Structural Characterization of a Chronic Myeloid Leukemia DNA Biosensor.". ACS chemical biology (2018): http://europepmc.org/abstract/med/29562136. 10.1021/acschembio.8b00029 Leisico F; V Vieira D; Figueiredo TA; Silva M; Cabrita EJ; Sobral RG; Ludovice AM; et al. "First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD.". Scientific reports (2018): http://europepmc.org/abstract/med/29593310. 10.1038/s41598-018-22986-3 Rosa, V.; Gaspari, A.P.S.; Folgosa, F.; Cordas, C.M.; Tavares, P.; Santos-Silva, T.; Barroso, S.; Avilés, T.. "Imine ligands based on ferrocene: Synthesis, structural and Mössbauer characterization and evaluation as chromogenic and electrochemical sensors for Hg²⁺". New Journal of Chemistry 42 5 (2018): 3334-3343. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042660639&partnerID=MN8TOARS. 10.1039/c7nj04319h Mota, C.; Coelho, C.; Leimkühler, S.; Garattini, E.; Terao, M.; Santos-Silva, T.; Romão, M.J.. "Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics". Coordination Chemistry Reviews 368 (2018): 35-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046125951&partnerID=MN8TOARS. 10.1016/j.ccr.2018.04.006 Azevedo CG; Correia I; Dos Santos MMC; Santos MFA; Santos-Silva T; Doutch J; Fernandes L; et al. "Binding of vanadium to human serum transferrin - voltammetric and spectrometric studies.". Journal of inorganic biochemistry (2017): http://europepmc.org/abstract/med/29355752. 10.1016/j.jinorgbio.2017.12.012 Pessoa JC; Correia I; Chorna I; Cavaco I; Roy S; Kuznetsov ML; Ribeiro N; et al. "Interaction of VIVO(acac)2 with human serum transferrin and albumin.". (2017): http://europepmc.org/abstract/med/28651041. 10.1002/asia.201700469 Otrelo-Cardoso, A.R.; Nair, R.R.; Correia, M.A.S.; Cordeiro, R.S.C.; Panjkovich, A.; Svergun, D.I.; Santos-Silva, T.; Rivas, M.G.. "Highly selective tungstate transporter protein TupA from Desulfovibrio alaskensis G20". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85025154506&partnerID=MN8TOARS. 10.1038/s41598-017-06133-y Watson, C.; Niks, D.; Hille, R.; Vieira, M.; Schoepp-Cothenet, B.; Marques, A.T.; Romão, M.J.; Santos-Silva, T.; Santini, J.M.. "Electron transfer through arsenite oxidase: Insights into Rieske interaction with cytochrome c". Biochimica et Biophysica Acta - Bioenergetics 1858 10 (2017): 865-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027491816&partnerID=MN8TOARS. 10.1016/j.bbabio.2017.08.003 Romao, Maria Joao; Coelho, Catarina; Santos-Silva, Teresa; Foti, Alessandro; Terao, Mineko; Garattini, Enrico; Leimkuhler, Silke. "Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics.". Current opinion in chemical biology 37 (2017): 39-47. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:28126656&KeyUID=MEDLINE:28126656. 10.1016/j.cbpa.2017.01.005 Correia MA; Otrelo-Cardoso AR; Schwuchow V; Sigfridsson Clauss KG; Haumann M; Romão MJ; Leimkühler S; Santos-Silva T. "The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes.". (2016): http://europepmc.org/abstract/med/27622978. 10.1021/acschembio.6b00572 Terao M; Romão MJ; Leimkühler S; Bolis M; Fratelli M; Coelho C; Santos-Silva T; Garattini E. "Structure and function of mammalian aldehyde oxidases.". (2016): http://europepmc.org/abstract/med/26920149. 10.1007/s00204-016-1683-1 Foti A; Hartmann T; Coelho C; Santos-Silva T; Romao MJ; Leimkuhler S. "Optimization of the expression of Human Aldehyde Oxidase for Investigations of Single Nucleotide Polymorphisms.". (2016): http://europepmc.org/abstract/med/26842593. Correia, M.A.S.; Otrelo-Cardoso, A.R.; Schwuchow, V.; Sigfridsson Clauss, K.G.V.; Haumann, M.; Romão, M.J.; Leimkühler, S.; Santos-Silva, T.. "The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes". ACS Chemical Biology 11 10 (2016): 2923-2935. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992170557&partnerID=MN8TOARS. 10.1021/acschembio.6b00572 Martins, Marta; Baptista, Pedro V.; Mendo, Ana Soraia; Correia, Claudia; Videira, Paula; Rodrigues, Antonio S.; Muthukumaran, J.; et al. "In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex". Molecular Biosystems 12 3 (2016): 1015-1023. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000371039800032&KeyUID=WOS:000371039800032. 10.1039/c5mb00791g Foti, Alessandro; Hartmann, Tobias; Coelho, Catarina; Santos-Silva, Teresa; Romao, Maria Joao; Leimkuehler, Silke. "Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms". Drug Metabolism and Disposition 44 8 (2016): 1277-1285. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000379415700017&KeyUID=WOS:000379415700017. 10.1124/dmd.115.068395 De Schutter, Amy; Correia, Hugo D.; Freire, Diana M.; Rivas, Maria G.; Rizzi, Alberto; Santos-Silva, Teresa; Gonzalez, Pablo J.; Van Doorslaer, Sabine. "Ligand Binding to Chlorite Dismutase from Magnetospirillum sp.". Journal of Physical Chemistry B 119 43 (2015): 13859-13869. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363994000044&KeyUID=WOS:000363994000044. 10.1021/acs.jpcb.5b04141 Freire, Diana M.; Rivas, Maria G.; Dias, Andre M.; Lopes, Ana T.; Costa, Cristina; Santos-Silva, Teresa; Van Doorslaer, Sabine; Gonzalez, Pablo J.. "The homopentameric chlorite dismutase from Magnetospirillum sp.". Journal of Inorganic Biochemistry 151 (2015): 1-9. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000367421100001&KeyUID=WOS:000367421100001. 10.1016/j.jinorgbio.2015.07.006 Coelho, C.; Foti, A.; Hartmann, T.; Santos-Silva, T.; Leimkühler, S.; Romão, M.J.. "Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase". Nature Chemical Biology 11 10 (2015): 779-783. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941876920&partnerID=MN8TOARS. 10.1038/nchembio.1895 Coelho, Catarina; Foti, Alessandro; Hartmann, Tobias; Santos-Silva, Teresa; Leimkuehler, Silke; Romao, Maria Joao. "Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase". Nature Chemical Biology 11 10 (2015): 779-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000361536500010&KeyUID=WOS:000361536500010. 10.1038/NCHEMBIO.1895 Correia, Hugo D.; Marangon, Jacopo; Brondino, Carlos D.; Moura, Jose J. G.; Romao, Maria J.; Gonzalez, Pablo J.; Santos-Silva, Teresa. "Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas: reactivity and molecular details of the enzyme-substrate and enzyme-product interaction (vol 20, pg 219, 2015)". Journal of Biological Inorganic Chemistry 20 2 (2015): 231-231. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000350236100006&KeyUID=WOS:000350236100006. 10.1007/s00775-014-1205-7 Seixas, Joao D.; Santos, Marino F. A.; Mukhopadhyay, Abhik; Coelho, Ana C.; Reis, Patricia M.; Veiros, Luis F.; Marques, Ana R.; et al. "A contribution to the rational design of Ru(CO)(3)Cl2L complexes for in vivo delivery of CO". Dalton Transactions 44 11 (2015): 5058-5075. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000350488300027&KeyUID=WOS:000350488300027. 10.1039/c4dt02966f Pessoa, Joao Costa; Garribba, Eugenio; Santos, Marino F. A.; Santos-Silva, Teresa. "Vanadium and proteins: Uptake, transport, structure, activity and function". Coordination Chemistry Reviews 301 (2015): 49-86. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000361264700004&KeyUID=WOS:000361264700004. 10.1016/j.ccr.2015.03.016 Correia HD; Marangon J; Brondino CD; Moura JJ; Romão MJ; González PJ; Santos-Silva T. "Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas: reactivity and molecular details of the enzyme-substrate and enzyme-product interaction.". (2014): http://europepmc.org/abstract/med/25261288. 10.1007/s00775-014-1196-4 Santos, Marino F. A.; Correia, Isabel; Oliveira, Ana R.; Garribba, Eugenio; Pessoa, Joao Costa; Santos-Silva, Teresa. "Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a V-IV Lysozyme Adduct". European Journal of Inorganic Chemistry 21 (2014): 3293-3297. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339481400001&KeyUID=WOS:000339481400001. 10.1002/ejic.201402408 Otrelo-Cardoso AR; Schwuchow V; Rodrigues D; Cabrita EJ; Leimkühler S; Romão MJ; Santos-Silva T. "Biochemical, stabilization and crystallization studies on a molecular chaperone (PaoD) involved in the maturation of molybdoenzymes.". (2014): http://europepmc.org/abstract/med/24498065. 10.1371/journal.pone.0087295 Pessoa, Joao Costa; Goncalves, Gisela; Roy, Somnath; Correia, Isabel; Mehtab, Sameena; Santos, Marino F. A.; Santos-Silva, Teresa. "New insights on vanadium binding to human serum transferrin". Inorganica Chimica Acta 420 (2014): 60-68. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000338356100009&KeyUID=WOS:000338356100009. 10.1016/j.ica.2013.11.025 Otrelo-Cardoso AR; da Silva Correia MA; Schwuchow V; Svergun DI; Romão MJ; Leimkühler S; Santos-Silva T. "Structural data on the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli: SAXS and preliminary X-ray crystallography analysis.". (2014): http://europepmc.org/abstract/med/24492481. 10.3390/ijms15022223 Otrelo-Cardoso AR; Nair RR; Correia MA; Rivas MG; Santos-Silva T. "TupA: a tungstate binding protein in the periplasm of Desulfovibrio alaskensis G20.". (2014): http://europepmc.org/abstract/med/24992597. 10.3390/ijms150711783 Marangon J; Correia HD; Brondino CD; Moura JJ; Romão MJ; González PJ; Santos-Silva T. "Kinetic and structural studies of aldehyde oxidoreductase from Desulfovibrio gigas reveal a dithiolene-based chemistry for enzyme activation and inhibition by H(2)O(2).". (2013): http://europepmc.org/abstract/med/24391748. 10.1371/journal.pone.0083234 Mehtab, S.; Gonçalves, G.; Roy, S.; Tomaz, A.I.; Santos-Silva, T.; Santos, M.F.A.; Romão, M.J.; et al. "Interaction of vanadium(IV) with human serum apo-transferrin". Journal of Inorganic Biochemistry 121 (2013): 187-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873700367&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2012.12.020 Seixas, J.D.; Mukhopadhyay, A.; Santos-Silva, T.; Otterbein, L.E.; Gallo, D.J.; Rodrigues, S.S.; Guerreiro, B.H.; et al. "Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics". Dalton Transactions 42 17 (2013): 5985-5998. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875795564&partnerID=MN8TOARS. 10.1039/c2dt32174b Santos, M.F.A.; Seixas, J.D.; Coelho, A.C.; Mukhopadhyay, A.; Reis, P.M.; Romão, M.J.; Romão, C.C.; Santos-Silva, T.. "New insights into the chemistry of fac-[Ru(CO)3]2 + fragments in biologically relevant conditions: The CO releasing activity of [Ru(CO)3Cl2(1,3-thiazole)], and the X-ray crystal structure of its adduct with lysozyme". Journal of Inorganic Biochemistry 117 (2012): 285-291. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869090746&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2012.06.018 Santos-Silva, T.; Mukhopadhyay, A.; Seixas, J.D.; Bernardes, G.J.L.; Romão, C.C.; Romão, M.J.. "Towards improved therapeutic CORMs: Understanding the reactivity of CORM-3 with proteins". Current Medicinal Chemistry 18 22 (2011): 3361-3366. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961084009&partnerID=MN8TOARS. 10.2174/092986711796504583 Santos-Silva, T.; Mukhopadhyay, A.; Seixas, J.D.; Bernardes, G.J.L.; Romão, C.C.; Romão, M.J.. "CORM-3 reactivity toward proteins: The crystal structure of a Ru(II) dicarbonyl-lysozyme complex". Journal of the American Chemical Society 133 5 (2011): 1192-1195. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551692596&partnerID=MN8TOARS. 10.1021/ja108820s Ribeiro, T.; Santos-Silva, T.; Alves, V.D.; Dias, F.M.V.; Luís, A.S.; Prates, J.A.M.; Ferreira, L.M.A.; Romão, M.J.; Fontes, C.M.G.A.. "Family 42 carbohydrate-binding modules display multiple arabinoxylan-binding interfaces presenting different ligand affinities". Biochimica et Biophysica Acta - Proteins and Proteomics 1804 10 (2010): 2054-2062. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956061008&partnerID=MN8TOARS. 10.1016/j.bbapap.2010.07.006 Honzícek, J.; Mukhopadhyay, A.; Santos-Silva, T.; Romão, M.J.; Romão, C.C.. "Ring-functionalized molybdenocene complexes". Organometallics 28 9 (2009): 2871-2879. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149128384&partnerID=MN8TOARS. 10.1021/om9001022 Santos-Silva, T.; Ferroni, F.; Thapper, A.; Marangon, J.; González, P.J.; Rizzi, A.C.; Moura, I.; et al. "Kinetic, structural, and EPR studies reveal that aldehyde oxidoreductase from Desulfovibrio gigas does not need a sulfido ligand for catalysis and give evidence for a direct Mo-C interaction in a biological system". Journal of the American Chemical Society 131 23 (2009): 7990-7998. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650531126&partnerID=MN8TOARS. 10.1021/ja809448r Vidinha, P.; Lourenço, N.M.T.; Pinheiro, C.; Brás, A.R.; Carvalho, T.; Santos-Silva, T.; Mukhopadhyay, A.; et al. "Ion jelly: A tailor-made conducting material for smart electrochemical devices". Chemical Communications 44 (2008): 5842-5844. http://www.scopus.com/inward/record.url?eid=2-s2.0-56349138178&partnerID=MN8TOARS. 10.1039/b811647d Santos-Silva, T.; Dias, J.M.; Dolla, A.; Durand, M.-C.; Gonçalves, L.L.; Lampreia, J.; Moura, I.; Romão, M.J.. "Crystal Structure of the 16 Heme Cytochrome from Desulfovibrio gigas: A Glycosylated Protein in a Sulphate-reducing Bacterium". Journal of Molecular Biology 370 4 (2007): 659-673. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249950618&partnerID=MN8TOARS. 10.1016/j.jmb.2007.04.055 Santos-Silva, T.; Trincão, J.; Carvalho, A.L.; Bonifácio, C.; Auchère, F.; Raleiras, P.; Moura, I.; Moura, J.J.G.; Romão, M.J.. "The first crystal structure of class III superoxide reductase from Treponema pallidum". Journal of Biological Inorganic Chemistry 11 5 (2006): 548-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745364810&partnerID=MN8TOARS. 10.1007/s00775-006-0104-y Santos-Silva, T.; Trincão, J.; Carvalho, A.L.; Bonifácio, C.; Auchère, F.; Moura, I.; Moura, J.J.G.; Romão, M.J.. "Superoxide reductase from the syphilis spirochete Treponema pallidum: Crystallization and structure determination using soft X-rays". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61 11 (2005): 967-970. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744487895&partnerID=MN8TOARS. 10.1107/S174430910502885X Santos-Silva, T.; Dias, J.M.; Bourenkov, G.; Bartunik, H.; Moura, I.; Romão, M.J.. "Crystallization and preliminary X-ray diffraction analysis of the 16-haem cytochrome of Desulfovibrio gigas". Acta Crystallographica Section D: Biological Crystallography 60 5 (2004): 968-970. http://www.scopus.com/inward/record.url?eid=2-s2.0-16644373383&partnerID=MN8TOARS. 10.1107/S0907444904005621 Hettmann, T.; Siddiqui, R.A.; Frey, C.; Santos-Silva, T.; Romão, M.J.; Diekmann, S.. "Mutagenesis study on amino acids around the molybdenum centre of the periplasmic nitrate reductase from Ralstonia eutropha". Biochemical and Biophysical Research Communications 320 4 (2004): 1211-1219. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142778495&partnerID=MN8TOARS. 10.1016/j.bbrc.2004.06.086
Capítulo de livro	Paquete-Ferreira, João; Leisico, Francisco; Correia, Márcia A. S.; Engrola, Filipa S. S.; Santos-Silva, Teresa; Santos, Marino F. A.. "Using Small-angle X-ray Scattering to Characterize Biological Systems: A General Overview and Practical Tips". In Advanced Methods in Structural Biology, 381-403. Springer US, 2023. Publicado • 10.1007/978-1-0716-3147-8_22 Engrola, Filipa S. S.; Paquete-Ferreira, João; Santos-Silva, Teresa; Correia, Márcia A. S.; Leisico, Francisco; Santos, Marino F. A.. "Screening of Buffers and Additives for Protein Stabilization by Thermal Shift Assay: A Practical Approach". In Advanced Methods in Structural Biology, 199-213. Springer US, 2023. Publicado • 10.1007/978-1-0716-3147-8_11

Outros

Outra produção

Ring-Functionalized Molybdenocene Complexes. 2009. Honzi´c¿ek J; Mukhopadhyay A; Santos-Silva T; Romao MJ; Romao CC. http://europepmc.org/abstract/CTX/C7709.
10.1002/om9001022

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2021/11/18	Surfing X-ray waves to discover proteins' atomic secrets - case studies ¿	XVI Annual Meeting of the Argentine Association of Crystallography (Santa Fé, Argentina)
2018	Molecular and Structural details of a diagnostic tool for Chronic Myeloid Leukemia”, ,	1st Biophysics Party Portugal, Oeiras, ITQB Instituto de Tecnologia Química e Biotecnológica (Oeiras, Portugal)
2018	“Integrating Structural Biology to understand peptidoglycan amidation in Staphylococcus aureus”,	Encontro com a Ciência - 2018, Lisboa, Portugal, 2018 Fundação para a Ciência e Tecnologia (Lisboa, Portugal)
2018	Development and Characterization of new nanoagents to treat Rheumatoid Arthritis	UCIBIO Annual Meeting, Caparica, Portugal, 2018. UCIBIO
2017	Structural Biology for Drug Desing”,	Centro de Química Estrutural, IST-ULisboa, Universidade de Lisboa Instituto Superior Técnico
2016	Metal complexes interacting with proteins - a crystallographic insight.	Conference cycle of C2TN-ULisboa, CENTER FOR NUCLEAR SCIENCES AND TECHNOLOGIES Universidade Lisboa (Loures, Portugal)
2016	The active-site pocket of trypsin: a dance hall	5º Encontro Nacional de Utilizadores de Radiação de Sincrotrão (ENURS - Meeting of the national users of synchrotron radiation) Instituto de Tecnologia Química e Biológica (Oeiras, Portugal)
2016	The Drug Metabolizing Aldehyde Oxidase from a Crystallographer's Point Of View	17th Drug Discovery Summit 17th Drug Discovery Summit (Berlin, Alemanha)
2014	Metal Complexes With Biological Activity – Structural Details Of Protein Adducts	French BioInorganic Chemistry Group meeting, French BioInorganic Chemistry Group meeting, (Biarritz, França)
2014	X-rays For The Structural Characterization Of Protein-ligand Interactions	UniCat Minisymposium: Research Area E2/D2 (Bio)Chemistry of COx conversions University of Berlin and University of Potsdam (Berlin, Alemanha)
2013	Bacterial monomeric aldehyde oxidoreductases	Molybdenum and Tungsten Enzyme Conference, 2013. Universidade Nova de Lisboa (Sintra, Portugal)
2013	How CO Releasing Molecules CO-RMs interact with proteins	Drug Discovery and Therapy World Congress 2013 Drug Discovery and Therapy World Congress (Boston, Estados Unidos)
2012	How CO Releasing Molecules CO-RMs interact with proteins	International Symposium on Metal Complexes Universidade de Lisboa (Lisboa, Portugal)
2011	CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II)Dicarbonyl-Lysozyme Complex	15th International Conference in Biological Inorganic Chemistry - ICBIC, University of Vancouver (Vancouver, Canadá)
2011	CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II)Dicarbonyl-Lysozyme Complex	3rd International Conference in Drug Discovery and Therapy, (Dubai, Emiratos Árabes Unidos)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2021/05/01 - Atual	The human Aldehyde Oxidase (hAOX1) - unravelling drug metabolisation Orientador	PhD (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/01/01 - Atual	"From proteins to Bacteria: a multidisciplinar approach for the rational development of new anti-biofilm and antibacterial agents" Orientador de João Carlos Paquete Ferreira	PhD (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2023	Structural and Functional Characterization of the Cancer-associated Epithelial Antigen STEAP1 Coorientador	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015 - 2022	Unraveling the enzymatic mechanism of glutamate amidation in S. aureus peptidoglycan Orientador	Biociências Moleculares (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2021/03/10	Structure and function of target proteins for the design of new inhibitors Orientador de Raqul Gama	Bioquímica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2020	Effects of CORM-3 formulations in in vitro and in vivo models of inflammation Orientador	Bioorgânica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019	LytR Inhibiton, an Approach to Avoid Biofilm Formation in Streptococcus dysgalactiae subs. dysgalactiae Orientador	Bioquímica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019	Filipa Sofia Silva EngrolaBacterial arsenite oxidation at the molecular level Orientador de Filipa Sofia Silva Engrola	Bioquímica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019	Structural and Functional Characterization of a New Bacterial Target Against Tuberculosis: The Phosphatase PtpA Orientador de Andreia Catarina Fernandes Pinto Fernandes	Bioquímica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018	Caracterização estrutural e funcional da MsmK, uma ATPase multitarefa de Streptoccocus pneumoniae Orientador	Bioorgânica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018	Structural and biophysical characterization of PtpA-inhibitors complexes: a possible target against tuberculosis Orientador	Química Bioorgânica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018	Development and CharacterizationofNanoagents to Rheumatoid Arthritis Orientador	Química Bioorgânica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2017	Structure based drug design for the discovery of promising anti-cancerous molecules Orientador	Bioquímica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2017	Structural studies on molybdenum-dependent enzymes: from transporters to enzymes Orientador	Bioquímica (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2016	Arsenito oxidasebacteriana:caracterização a nível molecular Orientador	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2016	Structural and Functional studies on the Reactivity of CORMs with plasma proteins Orientador	Bioquímica (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015	Estudo da interação proteína-ligando em proteases de serina para desenvolvimento de inibidores da Uroquinase Orientador	Bioquímica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015	Complexos Organometálicos: caraterização preliminar de compostos de vanádio e de moléculas libertadoras de CO como potenciais fármacos Orientador	Biotecnologia (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014	Structural and functional characterization of ModA and TupA proteins belonging to the molybdate and tungstate transport system from Desulfovibrio alaskensis G20 Coorientador	Bioquímica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2012	Estudos estruturais de interacções proteína-ligando: Aldeído Oxidorredutase e Tripsina Orientador de Hugo David Cancela Correia	Bioquímica Estrutural e Funcional (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2012	Estudos estruturais de enzimas de molibdénio e suas chaperonas Orientador	Biotecnologia (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2025/01/01 - Atual	Dr Teresa Santos-Silva co-organized the Pedagogical Innovation Days at NOVA FCT in 2025 and 2026, bringing together over 100 participants, including faculty, researchers, and educational practitioners. These events fostered dialogue, sharing of best practices, and collaborative reflection on innovative teaching approaches, reinforcing a culture of pedagogical development within the institution. (2025/01/22 - 2025/01/22) Conferência (Presidente da Comissão Organizadora)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023 - 2024	ECRICE 16 - European Conference on Research in Chemical Education (2023) Conferência (Membro da Comissão Organizadora)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2026/02/09	Dr Teresa Santos-Silva served as the main arguer for the PhD thesis in Biochemistry entitled “Biointeraction studies of recombinant HPV16 oncoproteins to discover therapeutic inhibitors,” developed by Diana Vanessa Duarte Gomes at the Faculty of Sciences of the University of Beira Interior, under the supervision of Prof. Ângela Maria Almeida de Sousa and co-supervision of Prof. Luís António Paulino Passarinha. In this role, she critically evaluated the scientific work and contributed to the academic discussion of the thesis. Arguente principal	Diana Vanessa Duarte Gomes (Doutoramento) Universidade da Beira Interior Faculdade de Ciências, Portugal
2019	Structural and Biochemical Analyses of Human and Sheep Xanthine Oxidoreductase Arguente principal	Brandon Charles Seychell (Doutoramento) University of Malta Faculty of Medicine and Surgery, Malta
2019	HIGH-THROUGHPUT PRODUCTION AND CHARACTERIZATION OF CARBOHYDRATE-ACTIVE ENZYMES FOR ANIMAL NUTRITION Arguente principal	VÂNIA ALEXANDRA DA SILVA CARDOSO LOPES (Doutoramento) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2017	Advances on anthracyclines-lipid membrane interactions: a biophysical approach Arguente principal	Ana Catarina Rodrigues Alves (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2017	Structural insights into the human multifunctional protein RuvBL2 Arguente	Sara Teresa Neves da Silva (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014	Crystallographic studies on membrane and cytoplasmic enzymes Arguente principal	Przemyslaw Michal Nogly (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2015 - 2015	6th European Conference on Chemistry in Life Sciences	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2025/12/01 - Atual	In 2025, Dr Teresa Santos-Silva served as an evaluator of pedagogical innovation projects at Egas Moniz, contributing her expertise in higher education, teaching practices, and innovation. In this role, she assessed project quality, impact, and alignment with educational goals, supporting the advancement of innovative approaches to teaching and learning. Avaliador	Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal
2019 - Atual	Project Evaluation Panel (PEC) of the PETRAIII synchrotron facility – biological applications: evaluation of beamtime proposals. Avaliador	European Molecular Biology Laboratory Hamburg, Alemanha	European Molecular Biology Laboratory Hamburg
2019 - 2022	Evaluation committee of the project's Final Scientific Report of Fundação para a Ciência e Tecnologia (Comissão de Avaliação dos Relatórios Científicos Finais de Projetos IC&DT 2019-2022) Avaliador	Fundação para a Ciência e a Tecnologia, Portugal
2013 - 2013	Referee of scientific projects from the Marsden Fund Royal Society of New Zealand Especialista	Marsden Fund Royal Society of New Zealand, Nova Zelândia	Marsden Fund Royal Society of New Zealand

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2023/05/01 - Atual	EUTOPIA - doctoral school	Communication skills (8h) (Doutoramento)	Universidade Nova de Lisboa, Portugal
2022/03/01 - Atual	Environmental Biochemistry (44 h/year)	Environmental Engineering (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - Atual	General Biochemistry to undergraduate students at FCT-UNL (44h/year).	Bioquimica geral (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - Atual	Pratical lessons of the subject Metabolismo e Regulação to undergraduate students of Biologia Molecular e Celular and Química Aplicada at FCT-UNL (44h/year).	Metabolismo e Regulação (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007 - Atual	Structural Biology to undergraduate students	Fundamentos de Bioquímica Estrutural (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007 - Atual	Structural Biology to MSc students	Bioquímica estrutural (Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2018	Invited teacher for the theoretical lessons of the course Modern Methods of Structure Elucidation (MMSE) at Instituto Superior Técnico, Universidade de Lisboa (ca 2h/year).	Modern Methods of Structure Elucidation (MMSE) (Doutoramento)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2017	Lecturing and co-organization of the unit core Methods for Biosciences II of the Doctoral Program MolBioS at ITQB and FCT – UNL (ca 30h/year).	Biociências Moleculares (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 - 2017	Invited teacher for the theoretical lessons of the subject Structural Biology at Instituto Superior Técnico, Universidade de Lisboa (ca 4h/year).	Structural Biology (Curso de mestrado (conclusão do curso de especialização))	Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2015	Lecturing and co-organization of the REQUIMTE course: ISBIO – integrative Structural Biology tools at FCT-UNL to graduate students (ca 8h/year).	ISBIO – integrative Structural Biology tools (Doutoramento)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2011	Lecturing and co-organization of the REQUIMTE summer course: Hands-On Course in Proteins and Proteomics at FCT-UNL to graduate students (ca 6h/year).	Hands-On Course in Proteins and Proteomics (Doutoramento)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2004 - 2010	Lecturing and co-organization of the REQUIMTE advanced course Curso Monográfico de Cristalografia de Proteínas in Departamento de Química of FCT-UNL (ca 30h/year).	Curso Monográfico de Cristalografia de Proteínas (Doutoramento)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007 - 2009	Invited teacher for the theoretical and practical lessons of the subject Principles of Structural Biochemistry at Faculdade de Ciências e Tecnologia, da Universidade de Coimbra (16h/year)	Principles of Structural Biochemistry	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2026/03/03	As Associate Dean for Pedagogical Innovation and Well-being at NOVA FCT, Dr Teresa Santos-Silva authored an article in Executive Digest, a leading Portuguese business magazine. Her contribution brings educational innovation and AI into dialogue with executive audiences, reinforcing her role in connecting academia with broader societal and organizational challenges.	Executive Digest
2015	-Vera Novais “Mais um passo para tornar os fármacos mais eficazes”, Observatório (2015)	Observatório
2015	Catarina Rocha “Enzima do fígado humano vista a 3D por cientistas portuguesas” Público (2015)	Público

Entrevista / Programa (rádio / tv)

	Programa	Tema
2018 - 2018	90 segundos de ciência, radio Antena 1	DE GÁS TÓXICO PARA AGENTE ANTI-INFLAMATÓRIO. INVESTIGADORA ESTUDA APLICAÇÃO DE MONÓXIDO DE CARBONO NO TRATAMENTO DA ARTRITE REUMATÓIDE

Membro de associação

	Nome da associação	Tipo de participação
2016 - Atual	Sociedade Portuguesa de Química	Member

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2026/03/23 - Atual	I have been nominated as NOVA FCT representative to the Faculty and Staff Council, contributing to institutional dialogue and decision-making processes. In this role, I support the representation of faculty perspectives and actively engage in the governance and strategic development of the academic community. Membro	Universidade Nova de Lisboa, Portugal
2024/12/01 - Atual	I am a member of Working Group 2 (WG2) of the COST Cross-Cutting Activity (CCA), contributing to its objectives of fostering interdisciplinary collaboration and addressing strategic research challenges across COST Actions. In this role, I engage in collaborative efforts to advance knowledge exchange and support the development of innovative, cross-disciplinary approaches within the COST framework. Membro	European Cooperation in Science and Technology, Bélgica
2018 - Atual	Thesis academic committee of student Andreia Fernandes at ITQB-NOVA, Portugal Consultor	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016 - Atual	Thesis academic committee of student Sofia Leonor Afonso Domingos at Faculdade de Farmácia Universidade de Lisboa, Portugal Consultor	Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - Atual	Thesis academic committee of student Paulo Espírito Santo at ITQB-NOVA, Portugal Consultor	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Tutoria

	Tópico	Nome do aluno
2025/05/01 - Atual	Organiser of the Mentorship Program at NOVA FCT	Organiser of the program

Distinções

Prémio

2014	Clara Immerwahr Award
2001	Second best student of undergraduation course Química Aplicada Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal