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sebastien walchli. Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: TCR; CAR; T cell; gene transfer; .
Identificação

Identificação pessoal

Nome completo
sebastien walchli

Nomes de citação

  • walchli, sebastien

Identificadores de autor

Ciência ID
7618-0A00-E81D
ORCID iD
0000-0001-5869-1746

Telefones

Telefone
  • (+47) 22 78 Ext.: 23 14 (Profissional)

Moradas

  • Ullernchausséen 70, 0379, Oslo, Oslo, Noruega (Profissional)

Websites

  • celltherapy.no (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Norueguês Bokmaal Utilizador independente (B2) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B2) Utilizador independente (B2)
Espanhol; Castelhano Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
1998/10/01 - 2002/09/30
Concluído
 Docteur ès Sciences mention biologie (Docteur)
Especialização em molecular biology
Université de Genève, faculté des Sciences, Suiça

Serono Pharmaceutical Research Institute, Suiça
"Substrate Recognition of Protein Tyrosine Phosphatases & PTP-SAP1, a Prototype Single Catalytic Domain Phosphatase" (TESE/DISSERTAÇÃO)
1996/09/01 - 1997/11/01
Concluído
 Biologie (Diplôme d´études supérieures)
Especialização em molecular biology
Université de Genève, faculté des Sciences, Suiça
"Description of two new genes involved in the heat-shock response in E. coli (trxC and prpC)" (TESE/DISSERTAÇÃO)
1993/08/30 - 1996/08/30
Concluído
 Biologie (Bachelor)
Université de Genève, faculté des Sciences, Suiça
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/08/01 - Atual Investigador principal (carreira) (Investigação) Oslo Universitetssykehus, Noruega
Radiumhospitalet Avdelning for kreftforebygging, Noruega
2007/01/01 - 2013/07/01 Investigador (Investigação) Oslo Universitetssykehus, Noruega
Oslo Universitetssykehus Institutt for kreftforskning, Noruega
2003/02/01 - 2006/12/31 Pós-doutorado (Investigação) Oslo Universitetssykehus, Noruega
Radiumhospitalet Avdeling for biokjemi, Noruega
Projetos

Bolsa

Designação Financiadores
2019/12/01 - Atual Pre-Clinical development of Chimeric Antigen Receptors (CARs) to treat solid tumours
2019062
Investigador responsável
Oslo Universitetssykehus, Noruega
Em curso
2019/02/02 - Atual Development of CXCR4 targeting -nanosystem-imaging probes for molecular imaging of cancer cells and tumor microenvironment
310531
Bolseiro de Integração na Investigação
Oslo Universitetssykehus, Noruega
2018/06/01 - Atual Clinical development of osteosarcoma CAR (OSCAR)
284983
1800091-6
1800091-6
Bolseiro de Integração na Investigação
Oslo Universitetssykehus, Noruega
Em curso
2015/10/01 - Atual CAR directed against lymphoma pre-clinical development & Novel CAR directed against lymphoma
6829007
2016006
Investigador responsável
Oslo Universitetssykehus, Noruega
2015/06/01 - 2018 A Universal Killer T-cell for Adoptive Cell Therapy of Cancer
244388
2010021
254817
Oslo Universitetssykehus, Noruega
Concluído
2014/01/01 - 2017/01/01 Personalized Immunotherapy: Re-targeting T-cells against cancer
244388
254817
2010021
244388
Desenvolvimento técnico
Oslo Universitetssykehus, Noruega
Concluído
2014/01/01 - 2016/01/01 Invariant chain as a vaccination vehicle for colorectal cancer
13/00367-88
Investigador responsável
Oslo Universitetssykehus, Noruega
Produções

Publicações

Artigo em revista
  1. Else Marit Inderberg; Sébastien Wälchli. "Sympathetic improvement of cancer vaccine efficacy". Human Vaccines & Immunotherapeutics (2020): https://doi.org/10.1080/21645515.2019.1703456.
    10.1080/21645515.2019.1703456
  2. Else Marit Inderberg; Sébastien Wälchli. "Long-term surviving cancer patients as a source of therapeutic TCR". Cancer Immunology, Immunotherapy (2020): https://doi.org/10.1007/s00262-019-02468-9.
    10.1007/s00262-019-02468-9
  3. Nadia Mensali; Marit Renée Myhre; Pierre Dillard; Sylvie Pollmann; Gustav Gaudernack; Gunnar Kvalheim; Sébastien Wälchli; Else Marit Inderberg. "Correction to: Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy". Cancer Immunology, Immunotherapy (2019): https://doi.org/10.1007/s00262-019-02409-6.
    10.1007/s00262-019-02409-6
  4. Nadia Mensali; Marit Renée Myhre; Pierre Dillard; Sylvie Pollmann; Gustav Gaudernack; Gunnar Kvalheim; Sébastien Wälchli; Else Marit Inderberg. "Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy". Cancer Immunology, Immunotherapy 68 8 (2019): 1235-1243. https://doi.org/10.1007/s00262-019-02356-2.
    10.1007/s00262-019-02356-2
  5. walchli, sebastien. "Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma.". Blood advances (2019): http://europepmc.org/articles/PMC6482360.
    10.1182/bloodadvances.2018029678
  6. Sarah E. Josefsson; Klaus Beiske; Yngvild N. Blaker; Mette S. Førsund; Harald Holte; Bjørn Østenstad; Eva Kimby; et al. "TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma". Cancer Immunology Research (2019): https://doi.org/10.1158/2326-6066.CIR-18-0351.
    10.1158/2326-6066.CIR-18-0351
  7. Nadia Mensali; Amalie Grenov; Niladri Bhusan Pati; Pierre Dillard; Marit Renée Myhre; Gustav Gaudernack; Gunnar Kvalheim; et al. "Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity". OncoImmunology 8 3 (2019): 1558663-1558663. https://doi.org/10.1080/2162402X.2018.1558663.
    10.1080/2162402X.2018.1558663
  8. Köksal, H.; Müller, E.; Inderberg, E.M.; Bruland, Ø.; Wälchli, S.. "Treating osteosarcoma with CAR T cells". Scandinavian Journal of Immunology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85059953175&partnerID=MN8TOARS.
    10.1111/sji.12741
  9. Mensali, N.; Dillard, P.; Hebeisen, M.; Lorenz, S.; Theodossiou, T.; Myhre, M.R.; Fåne, A.; et al. "NK cells specifically TCR-dressed to kill cancer cells". EBioMedicine (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060086029&partnerID=MN8TOARS.
    10.1016/j.ebiom.2019.01.031
  10. Margit H. Lampen; Hannes Uchtenhagen; Kim Blom; Renata Varnaite; Jolita Pakalniene; Laura Dailidyte; Sébastien Wälchli; et al. "Breadth and Dynamics of HLA-A2– and HLA-B7–Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection". ImmunoHorizons 2 6 (2018): 172-184. https://doi.org/10.4049/immunohorizons.1800029.
    10.4049/immunohorizons.1800029
  11. Dillard, P.; Köksal, H.; Inderberg, E.-M.; Wälchli, S.. "A Spheroid Killing Assay by CAR T Cells". Journal of visualized experiments : JoVE 142 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85059269465&partnerID=MN8TOARS.
    10.3791/58785
  12. Inderberg, E.M.; Mensali, N.; Oksvold, M.P.; Fallang, L.-E.; Fåne, A.; Skorstad, G.; Stenvik, G.-E.; et al. "Human c-SRC kinase (CSK) overexpression makes T cells dummy". Cancer Immunology, Immunotherapy 67 4 (2018): 525-536. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038105078&partnerID=MN8TOARS.
    10.1007/s00262-017-2105-9
  13. Våtsveen, T.K.; Myhre, M.R.; Steen, C.B.; Wälchli, S.; Lingjærde, O.C.; Bai, B.; Dillard, P.; et al. "Artesunate shows potent anti-tumor activity in B-cell lymphoma". Journal of Hematology and Oncology 11 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042314500&partnerID=MN8TOARS.
    10.1186/s13045-018-0561-0
  14. Even Walseng; Hakan Köksal; Ibrahim M. Sektioglu; Anne Fåne; Gjertrud Skorstad; Gunnar Kvalheim; Gustav Gaudernack; Else Marit Inderberg; Sébastien Wälchli. "A TCR-based Chimeric Antigen Receptor". Scientific Reports 7 1 (2017): https://doi.org/10.1038%2Fs41598-017-11126-y.
    10.1038/s41598-017-11126-y
  15. Myklebust, J.H.; Brody, J.; Kohrt, H.E.; Kolstad, A.; Czerwinski, D.K.; Wälchli, S.; Green, M.R.; et al. "Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling". Blood 129 6 (2017): 759-770. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014864984&partnerID=MN8TOARS.
    10.1182/blood-2016-05-718494
  16. Köksal, H.; Wälchli, S.. "Fishing therapeutic T-cell receptors in healthy donor blood, is safety predictable?". Translational Cancer Research 6 (2017): S622-S624. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019953427&partnerID=MN8TOARS.
    10.21037/tcr.2017.05.25
  17. Bollum, L.K.; Huse, K.; Oksvold, M.P.; Bai, B.; Hilden, V.I.; Forfang, L.; Yoon, S.O.; et al. "BMP-7 induces apoptosis in human germinal center B cells and". PLoS ONE 12 5 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018912752&partnerID=MN8TOARS.
    10.1371/journal.pone.0177188
  18. Inderberg, E.M.; Wälchli, S.; Myhre, M.R.; Trachsel, S.; Almåsbak, H.; Kvalheim, G.; Gaudernack, G.. "T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth". OncoImmunology 6 4 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018254865&partnerID=MN8TOARS.
    10.1080/2162402X.2017.1302631
  19. Belnoue, E.; Di Berardino-Besson, W.; Gaertner, H.; Carboni, S.; Dunand-Sauthier, I.; Cerini, F.; Suso-Inderberg, E.-M.; et al. "Enhancing antitumor immune responses by optimized combinations of cell-penetrating peptide-based vaccines and adjuvants". Molecular Therapy 24 9 (2016): 1675-1685. http://www.scopus.com/inward/record.url?eid=2-s2.0-84981252323&partnerID=MN8TOARS.
    10.1038/mt.2016.134
  20. Kyte, J.A.; Gaudernack, G.; Faane, A.; Lislerud, K.; Inderberg, E.M.; Brunsvig, P.; Aamdal, S.; et al. "T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy". OncoImmunology 5 12 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85002388785&partnerID=MN8TOARS.
    10.1080/2162402X.2016.1249090
  21. Mensali, N.; Ying, F.; Sheng, V.O.Y.; Yang, W.; Walseng, E.; Kumari, S.; Fallang, L.-E.; et al. "Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA". OncoImmunology 5 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84966700389&partnerID=MN8TOARS.
    10.1080/2162402X.2016.1138199
  22. Theodossiou, T.A.; Wälchli, S.; Olsen, C.E.; Skarpen, E.; Berg, K.. "Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity". ACS Chemical Biology 11 1 (2016): 251-262. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955288609&partnerID=MN8TOARS.
    10.1021/acschembio.5b00734
  23. Walseng, E.; Wälchli, S.; Fallang, L.-E.; Yang, W.; Vefferstad, A.; Areffard, A.; Olweus, J.. "Soluble T-cell receptors produced in human cells for targeted delivery". PLoS ONE 10 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928905266&partnerID=MN8TOARS.
    10.1371/journal.pone.0119559
  24. Tadesse, F.G.; Mensali, N.; Fallang, L.-E.; Walseng, E.; Yang, W.; Olweus, J.; Wälchli, S.. "Unpredicted phenotypes of two mutants of the TcR DMF5". Journal of Immunological Methods 425 (2015): 37-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943663673&partnerID=MN8TOARS.
    10.1016/j.jim.2015.06.006
  25. Wälchli, S.; Kumari, S.; Fallang, L.-E.; Sand, K.M.K.; Yang, W.; Landsverk, O.J.B.; Bakke, O.; Olweus, J.; Gregers, T.F.. "Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation". European Journal of Immunology 44 3 (2014): 774-784. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896030409&partnerID=MN8TOARS.
    10.1002/eji.201343671
  26. Kumari, S.; Wälchli, S.; Fallang, L.-E.; Yang, W.; Lund-Johansen, F.; Schumacher, T.N.; Olweus, J.. "Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes". Proceedings of the National Academy of Sciences of the United States of America 111 1 (2014): 403-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891938083&partnerID=MN8TOARS.
    10.1073/pnas.1306549111
  27. Gregers, T.F.; Skånland, S.S.; Wälchli, S.; Bakke, O.; Sandvig, K.. "BiP negatively affects ricin transport". Toxins 5 5 (2013): 969-982. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878059355&partnerID=MN8TOARS.
    10.3390/toxins5050969
  28. Huse, K.; Bakkebø, M.; Wälchli, S.; Oksvold, M.P.; Hilden, V.I.; Forfang, L.; Bredahl, M.L.; et al. "Role of Smad Proteins in Resistance to BMP-Induced Growth Inhibition in B-Cell Lymphoma". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867003141&partnerID=MN8TOARS.
    10.1371/journal.pone.0046117
  29. Zhen, Y.; Sørensen, V.; Skjerpen, C.S.; Haugsten, E.M.; Jin, Y.; Wälchli, S.; Olsnes, S.; Wiedlocha, A.. "Nuclear Import of Exogenous FGF1 Requires the ER-Protein LRRC59 and the Importins Kpna1 and Kpnß1". Traffic 13 5 (2012): 650-664. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859603522&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2012.01341.x
  30. Abrahamsen, I.W.; Kjellevoll, S.; Greve-Isdahl, M.; Mensali, N.; Wälchli, S.; Kumari, S.; Loland, B.F.; et al. "T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells". International Journal of Cancer 130 8 (2012): 1821-1832. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857500417&partnerID=MN8TOARS.
    10.1002/ijc.26209
  31. Sokolowska, I.; Wälchli, S.; W¿grzyn, G.; Sandvig, K.; Slominska-Wojewodzka, M.. "A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation". Biochemical Journal 436 2 (2011): 371-385. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956042755&partnerID=MN8TOARS.
    10.1042/BJ20101493
  32. Almåsbak, H.; Rian, E.; Hoel, H.J.; Pulè, M.; Wälchli, S.; Kvalheim, G.; Gaudernack, G.; Rasmussen, A.-M.. "Transiently redirected T cells for adoptive transfer". Cytotherapy 13 5 (2011): 629-640. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954490946&partnerID=MN8TOARS.
    10.3109/14653249.2010.542461
  33. Wälchli, S.; Løset, G.Å.; Kumari, S.; Johansen, J.N.; Yang, W.; Sandlie, I.; Olweus, J.. "A practical approach to T-cell receptor cloning and expression". PLoS ONE 6 11 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859222753&partnerID=MN8TOARS.
    10.1371/journal.pone.0027930
  34. Abrahamsen, I.W.; Stronen, E.; Wälchli, S.; Johansen, J.N.; Kjellevoll, S.; Kumari, S.; Komada, M.; et al. "Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif". Leukemia 24 11 (2010): 1901-1909. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149470173&partnerID=MN8TOARS.
    10.1038/leu.2010.186
  35. Yamazaki, T.; Wälchli, S.; Fujita, T.; Ryser, S.; Hoshijima, M.; Schlegel, W.; Kuroda, S.; Maturana, A.D.. "Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy". Cardiovascular Research 86 3 (2010): 374-382. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952395282&partnerID=MN8TOARS.
    10.1093/cvr/cvq023
  36. Skånland, S.S.; Wälchli, S.; Brech, A.; Sandvig, K.. "SNX4 in complex with clathrin and dynein: Implications for endosome movement". PLoS ONE 4 6 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67650110003&partnerID=MN8TOARS.
    10.1371/journal.pone.0005935
  37. Nygren, M.K.; Døsen-Dahl, G.; Stubberud, H.; Wälchli, S.; Munthe, E.; Rian, E.. "ß-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells". Experimental Hematology 37 2 (2009): 225-233. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149295502&partnerID=MN8TOARS.
    10.1016/j.exphem.2008.10.007
  38. Skånland, S.S.; Wälchli, S.; Sandvig, K.. "ß-arrestins attenuate p38-mediated endosome to Golgi transport". Cellular Microbiology 11 5 (2009): 796-807. http://www.scopus.com/inward/record.url?eid=2-s2.0-64049095622&partnerID=MN8TOARS.
    10.1111/j.1462-5822.2009.01292.x
  39. Stronen, E.; Abrahamsen, I.W.; Gaudernack, G.; Wälchli, S.; Munthe, E.; Buus, S.; Johansen, F.-E.; Lund-Johansen, F.; Olweus, J.. "Dendritic cells engineered to express defined Allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumour cells". Scandinavian Journal of Immunology 69 4 (2009): 319-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-61849182423&partnerID=MN8TOARS.
    10.1111/j.1365-3083.2008.02223.x
  40. Raa, H.; Grimmer, S.; Schwudke, D.; Bergan, J.; Wälchli, S.; Skotland, T.; Shevchenko, A.; Sandvig, K.. "Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin". Traffic 10 7 (2009): 868-882. http://www.scopus.com/inward/record.url?eid=2-s2.0-67249137905&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2009.00919.x
  41. Wälchli, S.; Aasheim, H.-C.; Skånland, S.S.; Spilsberg, B.; Torgersen, M.L.; Rosendal, K.R.; Sandvig, K.. "Characterization of clathrin and Syk interaction upon Shiga toxin binding". Cellular Signalling 21 7 (2009): 1161-1168. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349114550&partnerID=MN8TOARS.
    10.1016/j.cellsig.2009.03.005
  42. Maturana, A.D.; Wälchli, S.; Iwata, M.; Ryser, S.; Van Lint, J.; Hoshijima, M.; Schlegel, W.; et al. "Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel". Cardiovascular Research 78 3 (2008): 458-465. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449137885&partnerID=MN8TOARS.
    10.1093/cvr/cvn052
  43. Walchli, S.; Sioud, M.. "Vector-based delivery of siRNAs: In vitro and in vivo challenges". Frontiers in Bioscience 13 9 (2008): 3488-3493. http://www.scopus.com/inward/record.url?eid=2-s2.0-42649125223&partnerID=MN8TOARS.
    10.2741/2943
  44. Sørensen, V.; Zhen, Y.; Zakrzewska, M.; Haugsten, E.M.; Wälchli, S.; Nilsen, T.; Olsnes, S.; Wiedlocha, A.. "Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus". Molecular and Cellular Biology 28 12 (2008): 4129-4141. http://www.scopus.com/inward/record.url?eid=2-s2.0-44949253112&partnerID=MN8TOARS.
    10.1128/MCB.02117-07
  45. Wälchli, S.; Skånland, S.S.; Gregers, T.F.; Lauvrak, S.U.; Torgersen, M.L.; Ying, M.; Kuroda, S.; Maturana, A.; Sandvig, K.. "The mitogen-activated protein kinase p38 links Shiga toxin-dependent signaling and trafficking". Molecular Biology of the Cell 19 1 (2008): 95-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749099401&partnerID=MN8TOARS.
    10.1091/mbc.E07-06-0565
  46. Skånland, S.S.; Wälchli, S.; Utskarpen, A.; Wandinger-Ness, A.; Sandvig, K.. "Phosphoinositide-regulated retrograde transport of ricin: Crosstalk between hVps34 and sorting nexins". Traffic 8 3 (2007): 297-309. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247548363&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2006.00527.x
  47. Fujita, T.; Maturana, A.D.; Ikuta, J.; Hamada, J.; Walchli, S.; Suzuki, T.; Sawa, H.; et al. "Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells". Biochemical and Biophysical Research Communications 361 3 (2007): 605-610. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547732456&partnerID=MN8TOARS.
    10.1016/j.bbrc.2007.07.050
  48. Torgersen, M.L.; Wälchli, S.; Grimmer, S.; Skånland, S.S.; Sandvig, K.. "Protein kinase Cd is activated by shiga toxin and regulates its transport". Journal of Biological Chemistry 282 22 (2007): 16317-16328. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447536281&partnerID=MN8TOARS.
    10.1074/jbc.M610886200
  49. Slominska-Wojewodzka, M.; Gregers, T.F.; Wälchli, S.; Sandvig, K.. "EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol". Molecular Biology of the Cell 17 4 (2006): 1664-1675. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745395593&partnerID=MN8TOARS.
    10.1091/mbc.E05-10-0961
  50. Huynh, T.; Wälchli, S.; Sioud, M.. "Transcriptional targeting of small interfering RNAs into cancer cells". Biochemical and Biophysical Research Communications 350 4 (2006): 854-859. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750980120&partnerID=MN8TOARS.
    10.1016/j.bbrc.2006.09.127
  51. Lauvrak, S.U.; Wälchli, S.; Iversen, T.-G.; Slagsvold, H.H.; Torgersen, M.L.; Spilsberg, B.; Sandvig, K.. "Shiga toxin regulates its entry in a Syk-dependent manner". Molecular Biology of the Cell 17 3 (2006): 1096-1109. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644861755&partnerID=MN8TOARS.
    10.1091/mbc.E05-08-0766
  52. Bache, K.G.; Stuffers, S.; Malerød, L.; Slagsvold, T.; Raiborg, C.; Lechardeur, D.; Wälchli, S.; et al. "The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor". Molecular Biology of the Cell 17 6 (2006): 2513-2523. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744768359&partnerID=MN8TOARS.
    10.1091/mbc.E05-10-0915
  53. Utskarpen, A.; Slagsvold, H.H.; Iversen, T.-G.; Wälchli, S.; Sandvig, K.. "Transport of ricin from endosomes to the golgi apparatus is regulated by Rab6A and Rab6A'". Traffic 7 6 (2006): 663-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646423848&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2006.00418.x
  54. Grimmer, S.; Ying, M.; Wälchli, S.; van Deurs, B.; Sandvig, K.. "Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism". Traffic 6 2 (2005): 144-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-12744273521&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2005.00258.x
  55. Sioud, M.; Wälchli, S.. "Strategies for the design of random siRNA libraries and the selection of anti-GFP siRNAs.". Methods in molecular biology (Clifton, N.J.) 309 (2005): 83-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-25144446838&partnerID=MN8TOARS.
  56. Hetz, C.; Russelakis-Carneiro, M.; Wälchli, S.; Carboni, S.; Vial-Knecht, E.; Maundrell, K.; Castilla, J.; Soto, C.. "The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity". Journal of Neuroscience 25 11 (2005): 2793-2802. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244361681&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4090-04.2005
  57. Wälchli, S.; Espanel, X.; Van Huijsduijnen, R.H.. "Sap-1/PTPRH activity is regulated by reversible dimerization". Biochemical and Biophysical Research Communications 331 2 (2005): 497-502. http://www.scopus.com/inward/record.url?eid=2-s2.0-18044375383&partnerID=MN8TOARS.
    10.1016/j.bbrc.2005.03.196
  58. Spilsberg, B.; Sandvig, K.; Wälchli, S.. "Reconstitution of active diphtheria toxin based on a hexahistidine tagged version of the B-fragment produced to high yields in bacteria". Toxicon 46 8 (2005): 900-906. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444499318&partnerID=MN8TOARS.
    10.1016/j.toxicon.2005.08.015
  59. Sozio, M.S.; Mathis, M.A.; Young, J.A.; Wälchli, S.; Pitcher, L.A.; Wrage, P.C.; Bartók, B.; et al. "PTPH1 Is a Predominant Protein-tyrosine Phosphatase Capable of Interacting with and Dephosphorylating the T Cell Receptor ¿ Subunit". Journal of Biological Chemistry 279 9 (2004): 7760-7769. http://www.scopus.com/inward/record.url?eid=2-s2.0-10744226224&partnerID=MN8TOARS.
    10.1074/jbc.M309994200
  60. Wälchli, S.; Espanel, X.; Harrenga, A.; Rossi, M.; Cesareni, G.; Van Huijsduijnen, R.H.. "Probing Protein-tyrosine Phosphatase Substrate Specificity Using a Phosphotyrosine-containing Phage Library". Journal of Biological Chemistry 279 1 (2004): 311-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345791528&partnerID=MN8TOARS.
    10.1074/jbc.M307617200
  61. Espanel, X.; Wälchli, S.; Rückle, T.; Harrenga, A.; Huguenin-Reggiani, M.; Van Huijsduijnen, R.H.. "Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides". Journal of Biological Chemistry 278 17 (2003): 15162-15167. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038350881&partnerID=MN8TOARS.
    10.1074/jbc.M211887200
  62. Pasquali, C.; Curchod, M.-L.; Wälchli, S.; Espanel, X.; Guerrier, M.; Arigoni, F.; Strous, G.; Hooft Van Huijsduijnen, R.. "Identification of Protein Tyrosine Phosphatases with Specificity for the Ligand-Activated Growth Hormone Receptor". Molecular Endocrinology 17 11 (2003): 2228-2239. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242267059&partnerID=MN8TOARS.
    10.1210/me.2003-0011
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    10.1517/14728222.6.6.637
  64. Espanel, X.; Wälchli, S.; Gobert, R.P.; Alama, M.E.; Curchod, M.-L.; Gullu-Isler, N.; Hooft van Huijsduijnen, R.. "Pulling strings below the surface: Hormone receptor signaling through inhibition of protein tyrosine phosphatases". Endocrine 15 1 (2001): 19-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034864263&partnerID=MN8TOARS.
  65. Wälchli, S.; Colinge, J.; Hooft Van Huijsduijnen, R.. "MetaBlasts: Tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes". Gene 253 2 (2000): 137-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342656149&partnerID=MN8TOARS.
    10.1016/S0378-1119(00)00275-4
  66. Wälchli, S.; Curchod, M.-L.; Gobert, R.P.; Arkinstall, S.; Van Huijsduijnen, R.H.. "Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on 'substrate-trapping' mutants". Journal of Biological Chemistry 275 13 (2000): 9792-9796. http://www.scopus.com/inward/record.url?eid=2-s2.0-0039619868&partnerID=MN8TOARS.
    10.1074/jbc.275.13.9792
Atividades

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018 - Atual PIVAC 2018 meeting (2018/10/01)
Conferência (Membro da Comissão Organizadora)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2017/01/01 - Atual BMC Cancer (1471-2407) Springer (Biomed Central Ltd.)

Membro de associação

Nome da associação Tipo de participação
2018/01/01 - Atual EATRIS
2015/01/01 - Atual ESMO
2009/01/01 - Atual norwegian society for immunology secretary (2009-2011)

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2018 - Atual Swiss Cancer League European Research Council
Distinções

Prémio

2020 OVACURE challenge 2020
OvaCure Fundation, Dinamarca
2014 Innovation Award
Inven2, Noruega
2012 Top poster Award
CIMT (Association of Cancer Immunotherapy), Alemanha
2011 Innovation Award
Inven2, Noruega