| Artigo em revista |
- Matthew E.H. White; Jesús Gil; Edward W. Tate. "Proteome-wide structural analysis identifies warhead- and coverage-specific
biases in cysteine-focused chemoproteomics". Cell Chemical Biology (2023): https://doi.org/10.1016/j.chembiol.2023.06.021.
10.1016/j.chembiol.2023.06.021
- Elizabeth V. K. Ledger; Katie Lau; Edward W. Tate; Andrew M. Edwards. "XerC Is Required for the Repair of Antibiotic- and
Immune-Mediated DNA Damage in Staphylococcus aureus". Antimicrobial Agents and Chemotherapy (2023): https://doi.org/10.1128/aac.01206-22.
10.1128/aac.01206-22
- Emma C. Couves; Scott Gardner; Tomas B. Voisin; Jasmine K. Bickel; Phillip J. Stansfeld; Edward W. Tate; Doryen Bubeck. "Structural
basis for membrane attack complex inhibition by CD59". Nature Communications (2023): https://doi.org/10.1038/s41467-023-36441-z.
10.1038/s41467-023-36441-z
- Roman O. Fedoryshchak; Andrii Gorelik; Mengjie Shen; Maria M. Shchepinova; Inmaculada Pérez-Dorado; Edward W. Tate. "Discovery
of lipid-mediated protein–protein interactions in living cells using metabolic labeling with photoactivatable clickable probes".
Chemical Science (2023): https://doi.org/10.1039/D2SC06116C.
10.1039/D2SC06116C
- Milon Mondal; Daniel Conole; Jaya Nautiyal; Edward W. Tate. "UCHL1 as a novel target in breast cancer: emerging insights from
cell and chemical biology". British Journal of Cancer (2022): https://doi.org/10.1038/s41416-021-01516-5.
10.1038/s41416-021-01516-5
- Wouter W. Kallemeijn; Thomas Lanyon-Hogg; Nattawadee Panyain; Andrea Goya Grocin; Paulina Ciepla; Julia Morales-Sanfrutos;
Edward W. Tate. "Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification
and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation".
Nature Protocols (2021): https://doi.org/10.1038/s41596-021-00601-6.
10.1038/s41596-021-00601-6
- Andrea Goya Grocin; Wouter W. Kallemeijn; Edward W. Tate. "Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity".
Trends in Pharmacological Sciences (2021): https://doi.org/10.1016/j.tips.2021.07.004.
10.1016/j.tips.2021.07.004
- Elena De Vita; Daniel Lucy; Edward W. Tate. "Beyond targeted protein degradation: LD·ATTECs clear cellular lipid droplets".
Cell Research (2021): https://doi.org/10.1038/s41422-021-00546-1.
10.1038/s41422-021-00546-1
- Cassandra R. Kennedy; Andrea Goya Grocin; Tristan Kovacic; Ravi Singh; Jennifer A. Ward; Avinash R. Shenoy; Edward W. Tate.
"A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target". ACS Chemical Biology
(2021): https://doi.org/10.1021/acschembio.1c00218.
10.1021/acschembio.1c00218
- Benns, H.J.; Wincott, C.J.; Tate, E.W.; Child, M.A.. "Activity- and reactivity-based proteomics: Recent technological advances
and applications in drug discovery". Current Opinion in Chemical Biology 60 (2021): 20-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088930497&partnerID=MN8TOARS.
10.1016/j.cbpa.2020.06.011
- Losada de la Lastra, A.; Hassan, S.; Tate, E.W.. "Deconvoluting the biology and druggability of protein lipidation using chemical
proteomics". Current Opinion in Chemical Biology 60 (2021): 97-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096507708&partnerID=MN8TOARS.
10.1016/j.cbpa.2020.10.002
- Nattawadee Panyain; Aurélien Godinat; Aditya Raymond Thawani; Sofía Lachiondo-Ortega; Katie Mason; Sarah Elkhalifa; Lisa M.
Smith; Jeanine A. Harrigan; Edward W. Tate. "Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase
targets of a cyanopyrrolidine probe". RSC Medicinal Chemistry (2021): https://doi.org/10.1039/D1MD00218J.
10.1039/D1MD00218J
- Cyrille S. Kounde; Edward W. Tate. "Photoactive Bifunctional Degraders: Precision Tools To Regulate Protein Stability". Journal
of Medicinal Chemistry (2020): https://doi.org/10.1021/acs.jmedchem.0c01542.
10.1021/acs.jmedchem.0c01542
- Cyril Dian; Inmaculada Pérez-Dorado; Frédéric Rivière; Thomas Asensio; Pierre Legrand; Markus Ritzefeld; Mengjie Shen; et
al. "High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and
Gly myristoylation". Nature Communications (2020): https://doi.org/10.1038/s41467-020-14847-3.
10.1038/s41467-020-14847-3
- Elena De Vita; Maria Maneiro; Edward W. Tate. "The Missing Link between (Un)druggable and Degradable KRAS". ACS Central
Science (2020): https://doi.org/10.1021/acscentsci.0c00920.
10.1021/acscentsci.0c00920
- Mari´a Maneiro; Nafsika Forte; Maria M. Shchepinova; Cyrille S. Kounde; Vijay Chudasama; James Richard Baker; Edward W. Tate.
"Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4". ACS Chemical Biology (2020):
https://doi.org/10.1021/acschembio.0c00285.
10.1021/acschembio.0c00285
- Charlie N. Saunders; Ernesto Cota; Jake Baum; Edward W. Tate. "Peptide Probes for Plasmodium falciparum MyoA Tail Interacting
Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex". ACS Chemical Biology (2020): https://doi.org/10.1021/acschembio.0c00328.
10.1021/acschembio.0c00328
- Camilla TO Benfield; Farrell MacKenzie; Markus Ritzefeld; Michela Mazzon; Stuart Weston; Edward W Tate; Boon Han Teo; et al.
"Correction: Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain". Life Science
Alliance (2020): https://doi.org/10.26508/lsa.202000747.
10.26508/lsa.202000747
- Daniel Paolo Anderson; Henry James Benns; Edward William Tate; Matthew Andrew Child. "CRISPR - TAPE : protein-centric CRISPR
guide design for targeted proteome engineering". Molecular Systems Biology 16 6 (2020): https://doi.org/10.15252/msb.20209475.
10.15252/msb.20209475
- Jennifer A. Ward; Adan Pinto-Fernandez; Loïc Cornelissen; Sarah Bonham; Laura Díaz-Sáez; Olivier Riant; Kilian V. M. Huber;
et al. "Re-Evaluating the Mechanism of Action of a,ß-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic
Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs". Journal of Medicinal Chemistry
(2020): https://doi.org/10.1021/acs.jmedchem.0c00144.
10.1021/acs.jmedchem.0c00144
- Cesira de Chiara; Miha Homšak; Gareth A. Prosser; Holly L. Douglas; Acely Garza-Garcia; Geoff Kelly; Andrew G. Purkiss; Edward
W. Tate; Luiz Pedro S. de Carvalho. "d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition".
Nature Chemical Biology (2020): https://doi.org/10.1038/s41589-020-0498-9.
10.1038/s41589-020-0498-9
- Ainoa Rueda-Zubiaurre; Sabrina Yahiya; Oliver J. Fischer; Xiaojun Hu; Charlie N. Saunders; Sachi Sharma; Ursula Straschil;
et al. "Structure–Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes".
Journal of Medicinal Chemistry 63 5 (2020): 2240-2262. https://doi.org/10.1021/acs.jmedchem.9b00898.
10.1021/acs.jmedchem.9b00898
- Ryan T. Howard; Paul Hemsley; Philip Petteruti; Charlie N. Saunders; Javier A. Molina Bermejo; James S. Scott; Jeffrey W.
Johannes; Edward W. Tate. "Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for
PARP Inhibitors". ACS Chemical Biology (2020): https://doi.org/10.1021/acschembio.9b00963.
10.1021/acschembio.9b00963
- Camilla TO Benfield; Farrell MacKenzie; Markus Ritzefeld; Michela Mazzon; Stuart Weston; Edward Tate; Boon Han Teo; et al.
"Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain". Life Science Alliance
(2020): https://doi.org/10.26508/lsa.201900542.
10.26508/lsa.201900542
- Roman O. Fedoryshchak; Cory A. Ocasio; Benjamin Strutton; Jo Mattocks; Andrew J. Corran; Edward W. Tate. "Wheat pathogen Zymoseptoria
tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism". RSC
Chemical Biology 1 2 (2020): 68-78. https://doi.org/10.1039/D0CB00020E.
10.1039/D0CB00020E
- Simões, B.M.; Santiago-Gómez, A.; Chiodo, C.; Moreira, T.; Conole, D.; Lovell, S.; Alferez, D.; et al. "Targeting STAT3 signaling
using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer". Oncogene
39 25 (2020): 4896-4908. http://www.scopus.com/inward/record.url?eid=2-s2.0-85085550265&partnerID=MN8TOARS.
10.1038/s41388-020-1335-z
- Caengprasath, N.; Gonzalez-Abuin, N.; Shchepinova, M.; Ma, Y.; Inoue, A.; Tate, E.W.; Frost, G.; Hanyaloglu, A.C.. "Internalization-Dependent
Free Fatty Acid Receptor 2 Signaling Is Essential for Propionate-Induced Anorectic Gut Hormone Release". iScience 23
9 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85089812008&partnerID=MN8TOARS.
10.1016/j.isci.2020.101449
- Shchepinova, M.M.; Hanyaloglu, A.C.; Frost, G.S.; Tate, E.W.. "Chemical biology of noncanonical G protein–coupled receptor
signaling: Toward advanced therapeutics". Current Opinion in Chemical Biology 56 (2020): 98-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084798474&partnerID=MN8TOARS.
10.1016/j.cbpa.2020.04.012
- Panyain, N.; Godinat, A.; Lanyon-Hogg, T.; Lachiondo-Ortega, S.; Will, E.J.; Soudy, C.; Mondal, M.; et al. "Discovery of a
Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic
Activity". Journal of the American Chemical Society 142 28 (2020): 12020-12026. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088178239&partnerID=MN8TOARS.
10.1021/jacs.0c04527
- Shackley, M.; Ma, Y.; Tate, E.W.; Brown, A.J.H.; Frost, G.; Hanyaloglu, A.C.. "Short Chain Fatty Acids Enhance Expression
and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a Gai/o Pathway". Frontiers in Nutrition
7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85095996386&partnerID=MN8TOARS.
10.3389/fnut.2020.568991
- Fang, Z.; Chen, S.; Manchanda, Y.; Bitsi, S.; Pickford, P.; David, A.; Shchepinova, M.M.; et al. "Ligand-specific factors
influencing glp-1 receptor post-endocytic trafficking and degradation in pancreatic beta cells". International Journal
of Molecular Sciences 21 21 (2020): 1-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095842302&partnerID=MN8TOARS.
10.3390/ijms21218404
- Bell, A.S.; Yu, Z.; Hutton, J.A.; Wright, M.H.; Brannigan, J.A.; Paape, D.; Roberts, S.M.; et al. "Novel Thienopyrimidine
Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes". Journal of Medicinal
Chemistry 63 14 (2020): 7740-7765. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088488413&partnerID=MN8TOARS.
10.1021/acs.jmedchem.0c00570
- Barry, R.; Ruano-Gallego, D.; Radhakrishnan, S.T.; Lovell, S.; Yu, L.; Kotik, O.; Glegola-Madejska, I.; et al. "Faecal neutrophil
elastase-antiprotease balance reflects colitis severity". Mucosal Immunology 13 2 (2020): 322-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076225917&partnerID=MN8TOARS.
10.1038/s41385-019-0235-4
- Kryza, T.; Bock, N.; Lovell, S.; Rockstroh, A.; Lehman, M.L.; Lesner, A.; Panchadsaram, J.; et al. "The molecular function
of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer". Molecular Oncology
14 1 (2020): 105-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075748816&partnerID=MN8TOARS.
10.1002/1878-0261.12587
- Broncel, M.; Dominicus, C.; Vigetti, L.; Nofal, S.D.; Bartlett, E.J.; Touquet, B.; Hunt, A.; et al. "Profiling of myristoylation
in toxoplasma gondii reveals an n-myristoylated protein important for host cell penetration". eLife 9 (2020): 1-38.
http://www.scopus.com/inward/record.url?eid=2-s2.0-85088492475&partnerID=MN8TOARS.
10.7554/eLife.57861
- Tzakoniati, F.; Xu, H.; Li, T.; Garcia, N.; Kugel, C.; Payandeh, J.; Koth, C.M.; Tate, E.W.. "Development of Photocrosslinking
Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7". Cell Chemical Biology 27 3 (2020): 306-313.e4.
http://www.scopus.com/inward/record.url?eid=2-s2.0-85081317633&partnerID=MN8TOARS.
10.1016/j.chembiol.2019.10.011
- Lucy, D.; Zhang, L.; Tate, E.W.. "A Natural Product Puts Malaria on a Low-Fat Diet". Cell Chemical Biology 27 2 (2020):
137-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079345148&partnerID=MN8TOARS.
10.1016/j.chembiol.2020.02.001
- Panyain, N.; Godinat, A.; Lanyon-Hogg, T.; Lachiondo-Ortega, S.; Will, E.J.; Soudy, C.; Mondal, M.; et al. "Erratum: Discovery
of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with antifibrotic
activity (Journal of the American Chemical Society (2020) 142:28 (12020-12026) DOI: 10.1021/jacs.0c04527)". Journal of
the American Chemical Society 142 35 (2020): 15199-15199. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090250627&partnerID=MN8TOARS.
10.1021/jacs.0c08385
- Kounde, C.S.; Shchepinova, M.M.; Saunders, C.N.; Muelbaier, M.; Rackham, M.D.; Harling, J.D.; Tate, E.W.; et al. "A caged
E3 ligase ligand for PROTAC-mediated protein degradation with light". Chemical Communications 56 41 (2020): 5532-5535.
http://www.scopus.com/inward/record.url?eid=2-s2.0-85085264012&partnerID=MN8TOARS.
10.1039/d0cc00523a
- Tate, Edward W.. "Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases.". Cell chemical
biology (2019): https://doi.org/10.1016/j.chembiol.2019.03.006.
10.1016/j.chembiol.2019.03.006
- Tate, Edward W.. "Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics.".
Nature chemistry (2019): https://doi.org/10.1038/s41557-019-0237-6.
10.1038/s41557-019-0237-6
- Schlott AC; Mayclin S; Reers AR; Coburn-Flynn O; Bell AS; Green J; Knuepfer E; et al. "Structure-Guided Identification of
Resistance Breaking Antimalarial N-Myristoyltransferase Inhibitors.". Cell chemical biology (2019): http://europepmc.org/abstract/med/31080074.
10.1016/j.chembiol.2019.03.015
- Jamshidiha M; Pérez-Dorado I; Murray JW; Tate EW; Cota E; Read RJ. "Coping with strong translational noncrystallographic symmetry
and extreme anisotropy in molecular replacement with Phaser: human Rab27a.". Acta crystallographica. Section D, Structural
biology (2019): http://europepmc.org/abstract/med/30950405.
10.1107/S2059798318017825
- Tapodi A; Clemens DM; Uwineza A; Goldberg MW; Thinon E; Heal WP; Tate EW; et al. "BFSP1 C-terminal domains released by post-translational
processing events can alter significantly the calcium regulation of AQP0 water permeability.". Experimental eye research
(2019): http://europepmc.org/abstract/med/30790544.
10.1016/j.exer.2019.02.001
- Andrea Goya Grocin; Remigiusz A. Serwa; Julia Morales Sanfrutos; Markus Ritzefeld; Edward W. Tate; Tate, Edward W.. "Whole
Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A". Molecular & Cellular Proteomics
18 1 (2019): 115-126. https://doi.org/10.1074/mcp.RA118.001043.
10.1074/mcp.RA118.001043
- Hong WD; Benayoud F; Nixon GL; Ford L; Johnston KL; Clare RH; Cassidy A; et al. "AWZ1066S, a highly specific anti-Wolbachia
drug candidate for a short-course treatment of filariasis.". Proceedings of the National Academy of Sciences of the United
States of America (2019): http://europepmc.org/abstract/med/30617067.
10.1073/pnas.1816585116
- Benns HJ; Tate EW; Child MA. "Activity-Based Protein Profiling for the Study of Parasite Biology.". Current topics in microbiology
and immunology (2019): http://europepmc.org/abstract/med/30105424.
10.1007/82_2018_123
- McCluskey, S.P.; Haslop, A.; Coello, C.; Gunn, R.N.; Tate, E.W.; Southworth, R.; Plisson, C.; Long, N.J.; Wells, L.A.. "Imaging
of chemotherapy-induced acute cardiotoxicity with 18F-labeled lipophilic cations". Journal of Nuclear Medicine
60 12 (2019): 1750-1756. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075961456&partnerID=MN8TOARS.
10.2967/jnumed.119.226787
- Serwa, R.A.; Sekine, E.; Brown, J.; Teo, S.H.C.; Tate, E.W.; O’Hare, P.. "Analysis of a fully infectious bio-orthogonally
modified human virus reveals novel features of virus cell entry". PLoS Pathogens 15 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073578580&partnerID=MN8TOARS.
10.1371/journal.ppat.1007956
- Doll, S.; Freitas, F.P.; Shah, R.; Aldrovandi, M.; da Silva, M.C.; Ingold, I.; Grocin, A.G.; et al. "FSP1 is a glutathione-independent
ferroptosis suppressor". Nature 575 7784 (2019): 693-698. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074985624&partnerID=MN8TOARS.
10.1038/s41586-019-1707-0
- Birtley, J.R.; Alomary, M.; Zanini, E.; Antony, J.; Maben, Z.; Weaver, G.C.; Von Arx, C.; et al. "Inactivating mutations and
X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions". Nature Communications 10
1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85069512251&partnerID=MN8TOARS.
10.1038/s41467-019-10966-8
- Lanyon-Hogg, T.; Ritzefeld, M.; Sefer, L.; Bickel, J.K.; Rudolf, A.F.; Panyain, N.; Bineva-Todd, G.; et al. "Acylation-coupled
lipophilic induction of polarisation (Acyl-cLIP): A universal assay for lipid transferase and hydrolase enzymes". Chemical
Science 10 39 (2019): 8995-9000. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073415358&partnerID=MN8TOARS.
10.1039/c9sc01785b
- Beard, R.; Gaboriau, D.C.A.; Gee, A.D.; Tate, E.W.; Rhiannon Beard; David C. A. Gaboriau; Antony D. Gee; Edward W. Tate. "Chemical
biology tools for probing transcytosis at the blood-brain barrier". Chemical Science 10 46 (2019): 10772-10778. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075720425&partnerID=MN8TOARS.
10.1039/c9sc04024b
- Lim, C.S.Q.; Ha, K.P.; Clarke, R.S.; Gavin, L.-A.; Cook, D.T.; Hutton, J.A.; Sutherell, C.L.; et al. "Identification of a
potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant
Staphylococcus aureus". Bioorganic and Medicinal Chemistry 27 20 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068790400&partnerID=MN8TOARS.
10.1016/j.bmc.2019.06.025
- Conole, D.; Mondal, M.; Majmudar, J.D.; Tate, E.W.. "Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based
Probes". Frontiers in Chemistry 7 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077329334&partnerID=MN8TOARS.
10.3389/fchem.2019.00876
- Kaiser N; Mejuch T; Fedoryshchak R; Janning P; Tate EW; Waldmann H. "Photoactivatable Myristic Acid Probes for UNC119-Cargo
Interactions.". Chembiochem : a European journal of chemical biology (2018): http://europepmc.org/abstract/med/30129686.
10.1002/cbic.201800406
- Wang Z; Grosskurth SE; Cheung T; Petteruti P; Zhang J; Wang X; Wang W; et al. "Pharmacological inhibition of PARP6 triggers
multipolar spindle formation and elicits therapeutic effects in breast cancer.". Cancer research 78 23 (2018): 6691-6702.
http://europepmc.org/abstract/med/30297535.
10.1158/0008-5472.can-18-1362
- De Vita E; Schüler P; Lovell S; Lohbeck J; Kullmann S; Rabinovich E; Sananes A; et al. "Depsipeptides Featuring a Neutral
P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity.". Journal of medicinal chemistry
(2018): http://europepmc.org/abstract/med/30212625.
10.1021/acs.jmedchem.8b01106
- Furniss RCD; Low WW; Mavridou DAI; Dagley LF; Webb AI; Tate EW; Clements A. "Plasma membrane profiling during enterohemorrhagic
E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces.". The Journal of biological
chemistry (2018): http://europepmc.org/abstract/med/30190327.
10.1074/jbc.RA118.005114
- Gregory B. Craven; Dominic P. Affron; Charlotte E. Allen; Stefan Matthies; Joe G. Greener; Rhodri M. L. Morgan; Edward W.
Tate; Alan Armstrong; David J. Mann. "High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery". Angewandte
Chemie International Edition 57 19 (2018): 5257-5261. https://doi.org/10.1002/anie.201711825.
10.1002/anie.201711825
- Alzahofi N; Robinson CL; Welz T; Page EL; Briggs DA; Stainthorp AK; Reekes J; et al. "Rab27a co-ordinates actin-dependent
transport by controlling organelle-associated motors and track assembly proteins.". Nature Communications 11 1 (2018):
http://europepmc.org/abstract/PPR/PPR13489.
10.1101/314153
- Mousnier A; Bell AS; Swieboda DP; Morales-Sanfrutos J; Pérez-Dorado I; Brannigan JA; Newman J; et al. "Fragment-derived inhibitors
of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.". Nature chemistry
(2018): http://europepmc.org/abstract/med/29760414.
10.1038/s41557-018-0039-2
- Anja C. Schlott; Anthony A. Holder; Edward W. Tate. "N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase
Substrates in the Inhibitor Mode of Action". ACS Infectious Diseases (2018): https://doi.org/10.1021/acsinfecdis.7b00203.
10.1021/acsinfecdis.7b00203
- Alexandra S. Lubin; Ainoa Rueda-Zubiaurre; Holly Matthews; Hella Baumann; Fabio R. Fisher; Julia Morales-Sanfrutos; Kate S.
Hadavizadeh; et al. "Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium
falciparum". ACS Infectious Diseases (2018): https://doi.org/10.1021/acsinfecdis.7b00228.
10.1021/acsinfecdis.7b00228
- Pollard DJ; Berger CN; So EC; Yu L; Hadavizadeh K; Jennings P; Tate EW; Choudhary JS; Frankel G. "Broad-Spectrum Regulation
of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.". mBio (2018): http://europepmc.org/abstract/med/29636436.
10.1128/mBio.00170-18
- Beard R; Stucki A; Schmitt M; Py G; Grundschober C; Gee AD; Tate EW. "Building bridges for highly selective, potent and stable
oxytocin and vasopressin analogs.". Bioorganic & medicinal chemistry (2018): http://europepmc.org/abstract/med/29602673.
10.1016/j.bmc.2018.03.019
- Rhiannon Beard; Nisha Singh; Christophe Grundschober; Antony D. Gee; Edward W. Tate. "High-yielding 18F radiosynthesis of
a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo". Chemical Communications (2018):
https://doi.org/10.1039/C8CC01400K.
10.1039/C8CC01400K
- Ritzefeld, M.; Wright, M.H.; Tate, E.W.; Ritzefeld M; Wright MH; Tate EW. "New developments in probing and targeting protein
acylation in malaria, leishmaniasis and African sleeping sickness". Parasitology 145 2 (2018): 157-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014635940&partnerID=MN8TOARS.
10.1017/S0031182017000282
- Beard, R.; Singh, N.; Grundschober, C.; Gee, A.D.; Tate, E.W.. "High-yielding 18F radiosynthesis of a novel oxytocin
receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo". Chemical Communications 54 58 (2018): 8120-8123.
http://www.scopus.com/inward/record.url?eid=2-s2.0-85050193713&partnerID=MN8TOARS.
10.1039/c8cc01400k
- Pranzatelli MR; Tate ED; McGee NR. "Demographic, Clinical, and Immunologic Features of 389 Children with Opsoclonus-Myoclonus
Syndrome: A Cross-sectional Study.". Frontiers in neurology (2017): http://europepmc.org/abstract/med/28959231.
10.3389/fneur.2017.00468
- Lanyon-Hogg T; Faronato M; Serwa RA; Tate EW. "Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets.".
Trends in biochemical sciences (2017): http://europepmc.org/abstract/med/28602500.
10.1016/j.tibs.2017.04.004
- Clulow JA; Storck EM; Lanyon-Hogg T; Kalesh KA; Jones LH; Tate EW. "Competition-based, quantitative chemical proteomics in
breast cancer cells identifies new target profiles for sulforaphane.". Chemical communications (Cambridge, England)
(2017): http://europepmc.org/abstract/med/28439590.
10.1039/c6cc08797c
- Duluc L; Ahmetaj-Shala B; Mitchell J; Abdul-Salam VB; Mahomed AS; Aldabbous L; Oliver E; et al. "Tipifarnib prevents development
of hypoxia-induced pulmonary hypertension.". Cardiovascular research (2017): http://europepmc.org/abstract/med/28395021.
10.1093/cvr/cvw258
- Zhao W; Jamshidiha M; Lanyon-Hogg T; Recchi C; Cota E; Tate EW. "Direct Targeting of the Ras GTPase Superfamily Through Structure-
Based Design.". Current topics in medicinal chemistry (2017): http://europepmc.org/abstract/med/27530972.
10.2174/1568026616666160719165633
- Perdios L; Lowe AR; Saladino G; Bunney TD; Thiyagarajan N; Alexandrov Y; Dunsby C; et al. "Conformational transition of FGFR
kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.". Scientific reports
(2017): http://europepmc.org/abstract/med/28045057.
10.1038/srep39841
- Görlitz F; Kelly DJ; Warren SC; Alibhai D; West L; Kumar S; Alexandrov Y; et al. "Open Source High Content Analysis Utilizing
Automated Fluorescence Lifetime Imaging Microscopy.". Journal of visualized experiments : JoVE (2017): http://europepmc.org/abstract/med/28190060.
10.3791/55119
- Demetriadou A; Morales-Sanfrutos J; Nearchou M; Baba O; Kyriacou K; Tate EW; Drousiotou A; Petrou PP. "Mouse Stbd1 is N-myristoylated
and affects ER-mitochondria association and mitochondrial morphology.". Journal of cell science (2017): http://europepmc.org/abstract/med/28137759.
10.1242/jcs.195263
- Lanyon-Hogg T; Patel NV; Ritzefeld M; Boxall KJ; Burke R; Blagg J; Magee AI; Tate EW. "Microfluidic Mobility Shift Assay for
Real-Time Analysis of Peptide N-Palmitoylation.". SLAS discovery : advancing life sciences R & D (2017): http://europepmc.org/abstract/med/28296537.
10.1177/2472555216689529
- Goncalves V; Brannigan JA; Laporte A; Bell AS; Roberts SM; Wilkinson AJ; Leatherbarrow RJ; Tate EW. "Structure-guided optimization
of quinoline inhibitors of Plasmodium N-myristoyltransferase.". MedChemComm (2016): http://europepmc.org/abstract/med/28626547.
10.1039/c6md00531d
- Rodgers UR; Lanyon-Hogg T; Masumoto N; Ritzefeld M; Burke R; Blagg J; Magee AI; Tate EW. "Characterization of Hedgehog Acyltransferase
Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.". ACS chemical biology (2016):
http://europepmc.org/abstract/med/27779865.
10.1021/acschembio.6b00896
- Ward JA; McLellan L; Stockley M; Gibson KR; Whitlock GA; Knights C; Harrigan JA; Jacq X; Tate EW. "Quantitative Chemical Proteomic
Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.". ACS chemical biology (2016): http://europepmc.org/abstract/med/27779380.
10.1021/acschembio.6b00766
- Thinon E; Morales-Sanfrutos J; Mann DJ; Tate EW. "N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest,
and Apoptosis in Cancer Cells.". ACS chemical biology (2016): http://europepmc.org/abstract/med/27267252.
10.1021/acschembio.6b00371
- Albrow VE; Grimley RL; Clulow J; Rose CR; Sun J; Warmus JS; Tate EW; Jones LH; Storer RI. "Design and development of histone
deacetylase (HDAC) chemical probes for cell-based profiling.". Molecular bioSystems (2016): http://europepmc.org/abstract/med/27021930.
10.1039/c6mb00109b
- Wright MH; Paape D; Price HP; Smith DF; Tate EW. "Global Profiling and Inhibition of Protein Lipidation in Vector and Host
Stages of the Sleeping Sickness Parasite Trypanosoma brucei.". ACS infectious diseases (2016): http://europepmc.org/abstract/med/27331140.
10.1021/acsinfecdis.6b00034
- Lanyon-Hogg T; Masumoto N; Bodakh G; Konitsiotis AD; Thinon E; Rodgers UR; Owens RJ; Magee AI; Tate EW. "Synthesis and characterisation
of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.". Data in Brief (2016): http://europepmc.org/abstract/med/27077078.
10.1016/j.dib.2016.02.012
- Broncel, M.; Serwa, R.A.; Bunney, T.D.; Katan, M.; Tate, E.W.. "Global profiling of huntingtin-Associated protein e (HYPE)-mediated
Ampylation through a chemical proteomic approach". Molecular and Cellular Proteomics 15 2 (2016): 715-725. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957900425&partnerID=MN8TOARS.
10.1074/mcp.O115.054429
- So, E.C.; Schroeder, G.N.; Carson, D.; Mattheis, C.; Mousnier, A.; Broncel, M.; Tate, E.W.; et al. "The Rab-binding profiles
of bacterial virulence factors during infection". Journal of Biological Chemistry 291 11 (2016): 5832-5843. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973375954&partnerID=MN8TOARS.
10.1074/jbc.M115.700930
- Charlton TM; Kovacs-Simon A; Michell SL; Fairweather NF; Tate EW. "Quantitative Lipoproteomics in Clostridium difficile Reveals
a Role for Lipoproteins in Sporulation.". Chemistry & biology (2015): http://europepmc.org/abstract/med/26584780.
10.1016/j.chembiol.2015.10.006
- Broncel M; Serwa RA; Bunney TD; Katan M; Tate EW. "Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation
through a Chemical Proteomic Approach.". Molecular & cellular proteomics : MCP (2015): http://europepmc.org/abstract/med/26604261.
10.1074/mcp.o115.054429
- Lanyon-Hogg T; Masumoto N; Bodakh G; Konitsiotis AD; Thinon E; Rodgers UR; Owens RJ; Magee AI; Tate EW. "Click chemistry armed
enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.". Analytical biochemistry
(2015): http://europepmc.org/abstract/med/26334609.
10.1016/j.ab.2015.08.025
- Perdios L; Bunney TD; Warren SC; Dunsby C; French PMW; Tate EW; Katan M. "Time-resolved FRET reports FGFR1 dimerization and
formation of a complex with its effector PLC¿1.". Advances in biological regulation (2015): http://europepmc.org/abstract/med/26482290.
10.1016/j.jbior.2015.09.002
- Serwa RA; Abaitua F; Krause E; Tate EW; O'Hare P. "Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected
Cells Using Chemical Proteomics.". Chemistry & biology (2015): http://europepmc.org/abstract/med/26256475.
10.1016/j.chembiol.2015.06.024
- Rackham MD; Yu Z; Brannigan JA; Heal WP; Paape D; Barker KV; Wilkinson AJ; et al. "Discovery of high affinity inhibitors of
Leishmania donovani N-myristoyltransferase.". MedChemComm (2015): http://europepmc.org/abstract/med/26962429.
10.1039/c5md00241a
- Yu Z; Brannigan JA; Rangachari K; Heal WP; Wilkinson AJ; Holder AA; Leatherbarrow RJ; Tate EW. "Discovery of pyridyl-based
inhibitors of Plasmodium falciparum N-myristoyltransferase.". MedChemComm (2015): http://europepmc.org/abstract/med/26962430.
10.1039/c5md00242g
- Broncel M; Serwa RA; Ciepla P; Krause E; Dallman MJ; Magee AI; Tate EW. "Myristoylation profiling in human cells and zebrafish.".
Data in brief (2015): http://europepmc.org/abstract/med/26217820.
10.1016/j.dib.2015.06.010
- Nickel S; Serwa RA; Kaschani F; Ninck S; Zweerink S; Tate EW; Kaiser M. "Chemoproteomic Evaluation of the Polyacetylene Callyspongynic
Acid.". Chemistry (Weinheim an der Bergstrasse, Germany) (2015): http://europepmc.org/abstract/med/26079733.
10.1002/chem.201500934
- So EC; Mattheis C; Tate EW; Frankel G; Schroeder GN. "Creating a customized intracellular niche: subversion of host cell signaling
by Legionella type IV secretion system effectors.". Canadian journal of microbiology (2015): http://europepmc.org/abstract/med/26059316.
10.1139/cjm-2015-0166
- Lanyon-Hogg T; Ritzefeld M; Masumoto N; Magee AI; Rzepa HS; Tate EW. "Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines.".
The Journal of organic chemistry (2015): http://europepmc.org/abstract/med/25713927.
10.1021/acs.joc.5b00205
- Kalesh KA; Clulow JA; Tate EW. "Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative
chemical proteomics.". Chemical communications (Cambridge, England) (2015): http://europepmc.org/abstract/med/25598414.
10.1039/c4cc09527h
- Yusuf NA; Green JL; Wall RJ; Knuepfer E; Moon RW; Schulte-Huxel C; Stanway RR; et al. "The Plasmodium Class XIV Myosin, MyoB,
Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.". The
Journal of biological chemistry (2015): http://europepmc.org/abstract/med/25802338.
10.1074/jbc.m115.637694
- Broncel M; Serwa RA; Ciepla P; Krause E; Dallman MJ; Magee AI; Tate EW. "Multifunctional reagents for quantitative proteome-wide
analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.".
Angewandte Chemie (International ed. in English) (2015): http://europepmc.org/abstract/med/25807930.
10.1002/anie.201500342
- Wright MH; Paape D; Storck EM; Serwa RA; Smith DF; Tate EW. "Global analysis of protein N-myristoylation and exploration of
N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.". Chemistry & biology
(2015): http://europepmc.org/abstract/med/25728269.
10.1016/j.chembiol.2015.01.003
- Furse S; Mak L; Tate EW; Templer RH; Ces O; Woscholski R; Gaffney PR. "Synthesis of unsaturated phosphatidylinositol 4-phosphates
and the effects of substrate unsaturation on SopB phosphatase activity.". Organic & biomolecular chemistry (2015):
http://europepmc.org/abstract/med/25515724.
10.1039/c4ob02258k
- Masumoto, N.; Lanyon-Hogg, T.; Rodgers, U.R.; Konitsiotis, A.D.; Magee, A.I.; Tate, E.W.; Masumoto N; et al. "Membrane bound
O-acyltransferases and their inhibitors". Biochemical Society Transactions 43 (2015): 246-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84935020895&partnerID=MN8TOARS.
10.1042/BST20150018
- Schroeder, G.N.; Aurass, P.; Oates, C.V.; Tate, E.W.; Hartland, E.L.; Flieger, A.; Frankel, G.; et al. "Legionella pneumophila
effector LpdA Is a palmitoylated phospholipase D virulence factor". Infection and Immunity 83 10 (2015): 3989-4002.
http://www.scopus.com/inward/record.url?eid=2-s2.0-84944446943&partnerID=MN8TOARS.
10.1128/IAI.00785-15
- Yusuf, N.A.; Green, J.L.; Wall, R.J.; Knuepfer, E.; Moon, R.W.; Schulte-Huxel, C.; Stanway, R.R.; et al. "The Plasmodium class
XIV Myosin, MyoB, has a distinct subcellular location in invasive and motile stages of the malaria parasite and an unusual
light chain". Journal of Biological Chemistry 290 19 (2015): 12147-12164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929095673&partnerID=MN8TOARS.
10.1074/jbc.M115.637694
- Kelly, D.J.; Warren, S.C.; Alibhai, D.; Kumar, S.; Alexandrov, Y.; Munro, I.; Margineanu, A.; et al. "Automated multiwell
fluorescence lifetime imaging for Förster resonance energy transfer assays and high content analysis". Analytical Methods
7 10 (2015): 4071-4089. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929378119&partnerID=MN8TOARS.
10.1039/c5ay00244c
- Ciepla, P.; Magee, A.I.; Tate, E.W.; Ciepla P; Magee AI; Tate EW. "Cholesterylation: A tail of hedgehog". Biochemical Society
Transactions 43 (2015): 262-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934935737&partnerID=MN8TOARS.
10.1042/BST20150032
- Bunney TD; Cole AR; Broncel M; Esposito D; Tate EW; Katan M. "Crystal structure of the human, FIC-domain containing protein
HYPE and implications for its functions.". Structure (London, England : 1993) (2014): http://europepmc.org/abstract/med/25435325.
10.1016/j.str.2014.10.007
- Konitsiotis AD; Jovanovic B; Ciepla P; Spitaler M; Lanyon-Hogg T; Tate EW; Magee AI; et al. "Topological analysis of Hedgehog
acyltransferase, a multipalmitoylated transmembrane protein.". The Journal of biological chemistry 290 6 (2014): 3293-3307.
http://europepmc.org/abstract/med/25505265.
10.1074/jbc.m114.614578
- Paape D; Bell AS; Heal WP; Hutton JA; Leatherbarrow RJ; Tate EW; Smith DF. "Using a non-image-based medium-throughput assay
for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.". PLoS neglected tropical diseases
(2014): http://europepmc.org/abstract/med/25522361.
10.1371/journal.pntd.0003363
- Douse CH; Vrielink N; Wenlin Z; Cota E; Tate EW. "Targeting a dynamic protein-protein interaction: fragment screening against
the malaria myosin A motor complex.". ChemMedChem (2014): http://europepmc.org/abstract/med/25367834.
10.1002/cmdc.201402357
- Tate EW; Kalesh KA; Lanyon-Hogg T; Storck EM; Thinon E. "Global profiling of protein lipidation using chemical proteomic technologies.".
Current opinion in chemical biology (2014): http://europepmc.org/abstract/med/25461723.
10.1016/j.cbpa.2014.10.016
- Hutton JA; Goncalves V; Brannigan JA; Paape D; Wright MH; Waugh TM; Roberts SM; et al. "Structure-based design of potent and
selective Leishmania N-myristoyltransferase inhibitors.". Journal of medicinal chemistry (2014): http://europepmc.org/abstract/med/25238611.
10.1021/jm5011397
- Thinon E; Serwa RA; Broncel M; Brannigan JA; Brassat U; Wright MH; Heal WP; et al. "Global profiling of co- and post-translationally
N-myristoylated proteomes in human cells.". Nature communications (2014): http://europepmc.org/abstract/med/25255805.
10.1038/ncomms5919
- Olaleye TO; Brannigan JA; Roberts SM; Leatherbarrow RJ; Wilkinson AJ; Tate EW. "Peptidomimetic inhibitors of N-myristoyltransferase
from human malaria and leishmaniasis parasites.". Organic & biomolecular chemistry (2014): http://europepmc.org/abstract/med/25230674.
10.1039/c4ob01669f
- Douse CH; Maas SJ; Thomas JC; Garnett JA; Sun Y; Cota E; Tate EW. "Crystal structures of stapled and hydrogen bond surrogate
peptides targeting a fully buried protein-helix interaction.". ACS chemical biology (2014): http://europepmc.org/abstract/med/25084543.
10.1021/cb500271c
- Kalesh KA; Tate EW. "A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5.". Organic & biomolecular
chemistry (2014): http://europepmc.org/abstract/med/24848608.
10.1039/c4ob00773e
- Guttery DS; Poulin B; Ramaprasad A; Wall RJ; Ferguson DJ; Brady D; Patzewitz EM; et al. "Genome-wide functional analysis of
Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.". Cell host & microbe
(2014): http://europepmc.org/abstract/med/25011111.
10.1016/j.chom.2014.05.020
- Ciepla P; Konitsiotis AD; Serwa RA; Masumoto N; Leong WP; Dallman MJ; Magee AI; Tate EW. "New chemical probes targeting cholesterylation
of Sonic Hedgehog in human cells and zebrafish.". Chemical science (2014): http://europepmc.org/abstract/med/25574372.
10.1039/c4sc01600a
- Gray K; Elghadban S; Thongyoo P; Owen KA; Szabo R; Bugge TH; Tate EW; et al. "Potent and specific inhibition of the biological
activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II.". Thrombosis and
haemostasis 112 2 (2014): 402-411. http://europepmc.org/abstract/med/24696092.
10.1160/th13-11-0895
- Rackham MD; Brannigan JA; Rangachari K; Meister S; Wilkinson AJ; Holder AA; Leatherbarrow RJ; Tate EW. "Design and synthesis
of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency
dependent lipophilicity (LELP).". Journal of medicinal chemistry (2014): http://europepmc.org/abstract/med/24641010.
10.1021/jm500066b
- Konitsiotis AD; Chang SC; Jovanovic B; Ciepla P; Masumoto N; Palmer CP; Tate EW; Couchman JR; Magee AI. "Attenuation of hedgehog
acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human
carcinoma cells.". PloS one (2014): http://europepmc.org/abstract/med/24608521.
10.1371/journal.pone.0089899
- Brannigan, J.A.; Roberts, S.M.; Bell, A.S.; Hutton, J.A.; Hodgkinson, M.R.; Tate, E.W.; Leatherbarrow, R.J.; et al. "Diverse
modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors". IUCrJ 1 (2014):
250-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908364091&partnerID=MN8TOARS.
10.1107/S2052252514013001
- Wright MH; Clough B; Rackham MD; Rangachari K; Brannigan JA; Grainger M; Moss DK; et al. "Validation of N-myristoyltransferase
as an antimalarial drug target using an integrated chemical biology approach.". Nature chemistry (2013): http://europepmc.org/abstract/med/24451586.
10.1038/nchem.1830
- Poulin B; Patzewitz EM; Brady D; Silvie O; Wright MH; Ferguson DJ; Wall RJ; et al. "Unique apicomplexan IMC sub-compartment
proteins are early markers for apical polarity in the malaria parasite.". Biology open (2013): http://europepmc.org/abstract/med/24244852.
10.1242/bio.20136163
- Tate EW; Bell AS; Rackham MD; Wright MH; Tate, E.W.; Bell, A.S.; Rackham, M.D.; Wright, M.H.. "N-Myristoyltransferase as a
potential drug target in malaria and leishmaniasis.". Parasitology 141 1 (2013): 37-49. http://europepmc.org/abstract/med/23611109.
10.1017/s0031182013000450
- Storck, E.M.; Serwa, R.A.; Tate, E.W.; Storck EM; Serwa RA; Tate EW. "Chemical proteomics: A powerful tool for exploring protein
lipidation". Biochemical Society Transactions 41 1 (2013): 56-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873127663&partnerID=MN8TOARS.
10.1042/BST20120283
- Rackham MD; Brannigan JA; Moss DK; Yu Z; Wilkinson AJ; Holder AA; Tate EW; Leatherbarrow RJ. "Discovery of novel and ligand-efficient
inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.". Journal of medicinal chemistry (2012):
http://europepmc.org/abstract/med/23170970.
10.1021/jm301474t
- Alibhai D; Kelly DJ; Warren S; Kumar S; Margineau A; Serwa RA; Thinon E; et al. "Automated fluorescence lifetime imaging plate
reader and its application to Förster resonant energy transfer readout of Gag protein aggregation.". Journal of biophotonics
(2012): http://europepmc.org/abstract/med/23184449.
10.1002/jbio.201200185
- Yu Z; Brannigan JA; Moss DK; Brzozowski AM; Wilkinson AJ; Holder AA; Tate EW; Leatherbarrow RJ. "Design and synthesis of inhibitors
of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.". Journal of medicinal
chemistry (2012): http://europepmc.org/abstract/med/23035716.
10.1021/jm301160h
- Price HP; Hodgkinson MR; Wright MH; Tate EW; Smith BA; Carrington M; Stark M; Smith DF. "A role for the vesicle-associated
tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.". Biochimica et biophysica acta (2012):
http://europepmc.org/abstract/med/22609302.
10.1016/j.bbamcr.2012.05.007
- Goncalves V; Brannigan JA; Whalley D; Ansell KH; Saxty B; Holder AA; Wilkinson AJ; Tate EW; Leatherbarrow RJ. "Discovery of
Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding
mode.". Journal of medicinal chemistry (2012): http://europepmc.org/abstract/med/22439843.
10.1021/jm300040p
- Bell AS; Mills JE; Williams GP; Brannigan JA; Wilkinson AJ; Parkinson T; Leatherbarrow RJ; et al. "Selective inhibitors of
protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.". PLoS
neglected tropical diseases (2012): http://europepmc.org/abstract/med/22545171.
10.1371/journal.pntd.0001625
- Heal WP; Tate EW. "Application of activity-based protein profiling to the study of microbial pathogenesis.". Topics in
current chemistry (2012): http://europepmc.org/abstract/med/22102218.
10.1007/128_2011_299
- Broncel M; Serwa RA; Tate EW. "A new chemical handle for protein AMPylation at the host-pathogen interface.". Chembiochem
: a European journal of chemical biology (2012): http://europepmc.org/abstract/med/22213418.
10.1002/cbic.201100743
- Furse, S.; Brooks, N.J.; Seddon, A.M.; Woscholski, R.; Templer, R.H.; Tate, E.W.; Gaffney, P.R.J.; Ces, O.. "Lipid membrane
curvature induced by distearoyl phosphatidylinositol 4-phosphate". Soft Matter 8 11 (2012): 3090-3093. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857713751&partnerID=MN8TOARS.
10.1039/c2sm07358g
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plasmodium motor complex: Phosphorylation of myosin a tail-interacting protein (MTIP) loosens its grip on MyoA". Journal
of Biological Chemistry 287 44 (2012): 36968-36977. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868223075&partnerID=MN8TOARS.
10.1074/jbc.M112.379842
- Bradshaw, R.T.; Aronica, P.G.A.; Tate, E.W.; Leatherbarrow, R.J.; Gould, I.R.. "Mutational Locally Enhanced Sampling (MULES)
for quantitative prediction of the effects of mutations at protein-protein interfaces". Chemical Science 3 5 (2012):
1503-1511. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859327089&partnerID=MN8TOARS.
10.1039/c2sc00895e
- Heal WP; Wright MH; Thinon E; Tate EW. "Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration
by click chemistry.". Nature protocols (2011): http://europepmc.org/abstract/med/22193303.
10.1038/nprot.2011.425
- Goncalves V; Brannigan JA; Thinon E; Olaleye TO; Serwa R; Lanzarone S; Wilkinson AJ; Tate EW; Leatherbarrow RJ. "A fluorescence-based
assay for N-myristoyltransferase activity.". Analytical biochemistry (2011): http://europepmc.org/abstract/med/22051857.
10.1016/j.ab.2011.10.013
- Delmotte A; Tate EW; Yaliraki SN; Barahona M. "Protein multi-scale organization through graph partitioning and robustness
analysis: application to the myosin-myosin light chain interaction.". Physical biology (2011): http://europepmc.org/abstract/med/21832797.
10.1088/1478-3975/8/5/055010
- Tate EW; Goss RJ. "Highlights from the 46th EUCHEM Conference on stereochemistry, Bürgenstock, Switzerland, May 2011.". Chemical
communications (Cambridge, England) (2011): http://europepmc.org/abstract/med/21874182.
10.1039/c1cc90123k
- Tam Dang TH; Fagan RP; Fairweather NF; Tate EW. "Novel inhibitors of surface layer processing in Clostridium difficile.".
Bioorganic & medicinal chemistry (2011): http://europepmc.org/abstract/med/21752656.
10.1016/j.bmc.2011.06.042
- Serwa R; Tate EW. "Activity-based profiling for drug discovery.". Chemistry & biology (2011): http://europepmc.org/abstract/med/21513874.
10.1016/j.chembiol.2011.04.002
- de la Riva L; Willing SE; Tate EW; Fairweather NF; de la Riva, L.; Willing, S.E.; Tate, E.W.; Fairweather, N.F.. "Roles of
cysteine proteases Cwp84 and Cwp13 in biogenesis of the cell wall of Clostridium difficile.". Journal of bacteriology
193 13 (2011): 3276-3285. http://europepmc.org/abstract/med/21531808.
10.1128/jb.00248-11
- Heal WP; Jovanovic B; Bessin S; Wright MH; Magee AI; Tate EW. "Bioorthogonal chemical tagging of protein cholesterylation
in living cells.". Chemical communications (Cambridge, England) (2011): http://europepmc.org/abstract/med/21221452.
10.1039/c0cc04710d
- Heal WP; Dang TH; Tate EW. "Activity-based probes: discovering new biology and new drug targets.". Chemical Society reviews
(2010): http://europepmc.org/abstract/med/20886146.
10.1039/c0cs00004c
- Bradshaw RT; Patel BH; Tate EW; Leatherbarrow RJ; Gould IR. "Comparing experimental and computational alanine scanning techniques
for probing a prototypical protein-protein interaction.". Protein engineering, design & selection : PEDS (2010): http://europepmc.org/abstract/med/20656696.
10.1093/protein/gzq047
- Berry AF; Heal WP; Tarafder AK; Tolmachova T; Baron RA; Seabra MC; Tate EW. "Rapid multilabel detection of geranylgeranylated
proteins by using bioorthogonal ligation chemistry.". Chembiochem : a European journal of chemical biology (2010):
http://europepmc.org/abstract/med/20209562.
10.1002/cbic.201000087
- Dang TH; de la Riva L; Fagan RP; Storck EM; Heal WP; Janoir C; Fairweather NF; Tate EW. "Chemical probes of surface layer
biogenesis in Clostridium difficile.". ACS chemical biology (2010): http://europepmc.org/abstract/med/20067320.
10.1021/cb9002859
- So S; Peeva LG; Tate EW; Leatherbarrow RJ; Livingston AG. "Membrane enhanced peptide synthesis.". Chemical communications
(Cambridge, England) (2010): http://europepmc.org/abstract/med/20369190.
10.1039/b926747f
- Thomas JC; Green JL; Howson RI; Simpson P; Moss DK; Martin SR; Holder AA; Cota E; Tate EW. "Interaction and dynamics of the
Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.". Molecular bioSystems
(2010): http://europepmc.org/abstract/med/20174678.
10.1039/b922093c
- So, S.; Peeva, L.G.; Tate, E.W.; Leatherbarrow, R.J.; Livingston, A.G.. "Organic solvent nanofiltration: A new paradigm in
peptide synthesis". Organic Process Research and Development 14 6 (2010): 1313-1325. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649643372&partnerID=MN8TOARS.
10.1021/op1001403
- Heal WP; Tate EW. "Getting a chemical handle on protein post-translational modification.". Organic & biomolecular chemistry
(2009): http://europepmc.org/abstract/med/20135026.
10.1039/b917894e
- Brannigan JA; Smith BA; Yu Z; Brzozowski AM; Hodgkinson MR; Maroof A; Price HP; et al. "N-myristoyltransferase from Leishmania
donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis.". Journal of
molecular biology (2009): http://europepmc.org/abstract/med/20036251.
10.1016/j.jmb.2009.12.032
- Wright MH; Heal WP; Mann DJ; Tate EW. "Protein myristoylation in health and disease.". Journal of chemical biology
(2009): http://europepmc.org/abstract/med/19898886.
10.1007/s12154-009-0032-8
- Thongyoo P; Bonomelli C; Leatherbarrow RJ; Tate EW. "Potent inhibitors of beta-tryptase and human leukocyte elastase based
on the MCoTI-II scaffold.". Journal of medicinal chemistry (2009): http://europepmc.org/abstract/med/19772295.
10.1021/jm901233u
- Heal WP; Wickramasinghe SR; Tate EW. "Activity based chemical proteomics: profiling proteases as drug targets.". Current
drug discovery technologies (2008): http://europepmc.org/abstract/med/18690889.
10.2174/157016308785739866
- Busch GK; Tate EW; Gaffney PR; Rosivatz E; Woscholski R; Leatherbarrow RJ. "Specific N-terminal protein labelling: use of
FMDV 3C pro protease and native chemical ligation.". Chemical communications (Cambridge, England) (2008): http://europepmc.org/abstract/med/18633492.
10.1039/b806727a
- Tate EW. "Recent advances in chemical proteomics: exploring the post-translational proteome.". Journal of chemical biology
(2008): http://europepmc.org/abstract/med/19568795.
10.1007/s12154-008-0002-6
- Heal WP; Wickramasinghe SR; Leatherbarrow RJ; Tate EW. "N-Myristoyl transferase-mediated protein labelling in vivo.". Organic
& biomolecular chemistry (2008): http://europepmc.org/abstract/med/18563263.
10.1039/b803258k
- Bowyer PW; Tate EW; Leatherbarrow RJ; Holder AA; Smith DF; Brown KA. "N-myristoyltransferase: a prospective drug target for
protozoan parasites.". ChemMedChem (2008): http://europepmc.org/abstract/med/18324715.
10.1002/cmdc.200700301
- Thongyoo P; Roqué-Rosell N; Leatherbarrow RJ; Tate EW. "Chemical and biomimetic total syntheses of natural and engineered
MCoTI cyclotides.". Organic & biomolecular chemistry (2008): http://europepmc.org/abstract/med/18385853.
10.1039/b801667d
- Bowyer PW; Gunaratne RS; Grainger M; Withers-Martinez C; Wickramsinghe SR; Tate EW; Leatherbarrow RJ; et al. "Molecules incorporating
a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.". The Biochemical journal
408 2 (2007): 173-180. http://europepmc.org/abstract/med/17714074.
10.1042/bj20070692
- Heal WP; Wickramasinghe SR; Bowyer PW; Holder AA; Smith DF; Leatherbarrow RJ; Tate EW. "Site-specific N-terminal labelling
of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.". Chemical communications
(Cambridge, England) (2007): http://europepmc.org/abstract/med/18188474.
10.1039/b716115h
- Thongyoo P; Jaulent AM; Tate EW; Leatherbarrow RJ. "Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins.".
Chembiochem : a European journal of chemical biology (2007): http://europepmc.org/abstract/med/17526063.
10.1002/cbic.200700187
- Thongyoo P; Tate EW; Leatherbarrow RJ. "Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II.". Chemical
communications (Cambridge, England) (2006): http://europepmc.org/abstract/med/17007393.
10.1039/b607324g
- Tate EW; Dixon DJ; Ley SV. "A highly enantioselective total synthesis of (+)-goniodiol.". Organic & biomolecular chemistry
(2006): http://europepmc.org/abstract/med/16633562.
10.1039/b602805e
- Tate, E.W.. "Chemical intervention in signalling networks: Recent advances and applications". Signal Transduction 6
2 (2006): 144-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646372429&partnerID=MN8TOARS.
10.1002/sita.200500075
- Tate, E.W.; Bowyer, P.W.; Brown, K.A.; Smith, D.F.; Holder, A.A.; Leatherbarrow, R.J.. "Peptide-based inhibitors of N-myristoyl
transferase generated from a lipid/combinatorial peptide chimera library". Signal Transduction 6 2 (2006): 160-166.
http://www.scopus.com/inward/record.url?eid=2-s2.0-33646359916&partnerID=MN8TOARS.
10.1002/sita.200500084
- Kalaï, C.; Tate, E.; Zard, S.Z.. "A short formal route to (±)-lepadin B using a xanthate-mediated free radical cyclisation/vinylation
sequence". Chemical Communications 2 13 (2002): 1430-1431. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036080620&partnerID=MN8TOARS.
10.1039/b203604e
- Tate, E.W.; Zard, S.Z.. "Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition
and Mannich cyclisation cascade". Tetrahedron Letters 43 26 (2002): 4683-4686. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037189175&partnerID=MN8TOARS.
10.1016/S0040-4039(02)00835-3
- Buffet, M.F.; Dixon, D.J.; Edwards, G.L.; Ley, S.V.; Tate, E.W.. "Oxygen to carbon rearrangements of anomerically linked alkenols
from tetrahydropyran derivatives: An investigation of the reaction mechanism via a double isotopic labelling crossover study".
Journal of the Chemical Society, Perkin Transactions 1 12 (2000): 1815-1827. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034697707&partnerID=MN8TOARS.
10.1039/a909300a
- Dixon, D.J.; Ley, S.V.; Tate, E.W.. "The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation
of tetrahyclropyranyl ether derivatives". Journal of the Chemical Society, Perkin Transactions 1 12 (2000): 1829-1836.
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034697720&partnerID=MN8TOARS.
10.1039/a909302h
- Dixon, D.J.; Ley, S.V.; Tate, E.W.. "Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers
and the total synthesis of (+)-(S,S)-cis-6-methyltetrahydropyran-2-ylacetic acid, a component of civet". Journal of the
Chemical Society, Perkin Transactions 1 15 (2000): 2385-2394. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034618265&partnerID=MN8TOARS.
10.1039/b001243m
- Dixon, D.J.; Ley, S.V.; Tate, E.W.. "Highly cis- or fraws-selective oxygen to carbon rearrangements of anomerically linked
6-substituted tetrahydropyranyl enol ethers". Journal of the Chemical Society - Perkin Transactions 1 19 (1999): 2665-2667.
http://www.scopus.com/inward/record.url?eid=2-s2.0-0001322924&partnerID=MN8TOARS.
10.1039/a904891j
- Dixon, D.J.; Ley, S.V.; Tate, E.W.. "A total synthesis of (+)-Goniodiol using an anomeric oxygen-to-carbon rearrangement".
Journal of the Chemical Society - Perkin Transactions 1 19 (1998): 3125-3126. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749115510&partnerID=MN8TOARS.
10.1039/a806584e
- Buffet, M.F.; Dixon, D.J.; Ley, S.V.; Tate, E.W.. "Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives
of lactols". Synlett 10 (1998): 1091-1092. http://www.scopus.com/inward/record.url?eid=2-s2.0-0002282303&partnerID=MN8TOARS.
10.1055/s-1998-1866
- Dixon, D.J.; Ley, S.V.; Tate, E.W.. "Diastereoselective anomeric oxygen to carbon rearrangements of silyl enol ether derivatives
of lactols". Synlett 10 (1998): 1093-1095. http://www.scopus.com/inward/record.url?eid=2-s2.0-0002348183&partnerID=MN8TOARS.
10.1055/s-1998-1867
- Buffet, M.F.; Dixon, D.J.; Edwards, G.L.; Ley, S.V.; Tate, E.. "A General C-Glycosidation Procedure via Anomeric Oxygen to
Carbon Rearrangements of Tetrahydropyranyl Ether Derivatives". Synlett 1997 9 (1997): 1055-1056. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001923328&partnerID=MN8TOARS.
10.1055/s-1997-1531
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