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Diana Sousa is a first year PhD student in the PhD Programme in Experimental Biology and Biomedicine (PDBEB) at the University of Coimbra. She got her BSc degree in Biochemistry in 2020 at the University of Coimbra. Diana concluded her master in Cellular and Molecular Biology at the University of Coimbra in 2022. In 2023, she was a research fellow at the NeuroEndocrinology of Obesity Laboratory at Coimbra Institute for Clinical and Biomedical Research (iCBR - CIBB) at the University of Coimbra, where she work with adipose tissue dopaminergic signalling in the context of obesity. Her master's dissertation focused on the impact of obesogenic environments on offspring energy balance mechanisms. In this context, she has published an original article in Nutrients (10.3390/nu15051281), and a review paper in elucidating the relationship between neuropeptide Y and mitochondria in Biomedicine (10.3390/biomedicines11020446). Diana is also a coauthor of two original articles revealing the neurometabolic alterations in metabolic programming context (10.1016/j.lfs.2023.121597 and 10.3390/nu15163581). She as participated in international meetings, namely the European Congress of Clinical Investigation (ESCI) in 2022 and 2023 as an author and co-author of oral communications and posters, and in the European Association for the Study of Diabetes meeting in 2022 and 2023 (short oral communication). Regarding national congresses, Diana also presented oral communications at the Portuguese Congress of Diabetes in 2022 and 2023 and at the Portuguese Congress of Pharmacology in 2023.
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Identificação

Identificação pessoal

Nome completo
Diana Sousa

Nomes de citação

  • Sousa, Diana

Identificadores de autor

Ciência ID
7013-2EFB-4953

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2023/10/02 - 2027/09
Em curso
 PhD Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09 - 2022/09
Concluído
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Offspring Programming of central and peripheral nutrient-sensing pathways by the exposition to perinatal obesogenic environments" (TESE/DISSERTAÇÃO)
 19
2017/09 - 2020/07
Concluído
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 15.1
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/10/03 - Atual Investigador (Investigação) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Horizon Europe, Bélgica
2024/02/04 - 2024/03/05 Estagiário de Investigação (Investigação) Karolinska Institutet - Huddinge Campus, Suécia
2023/05 - 2023/09 Investigador (Investigação) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Fundação para a Ciência e a Tecnologia, Portugal
2021/10 - 2023/04 Estagiário de Investigação (Investigação) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
2021/09 - 2021/09 Investigador (Investigação) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Fundação para a Ciência e a Tecnologia, Portugal
2021/02 - 2021/08 Estagiário de Investigação (Investigação) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
2021/01 - 2021/01 Estagiário de Investigação (Investigação) CNC - Center for Neuroscience and Cell Biology, Portugal
2020/02/01 - 2020/06/30 Estagiário de Investigação (Investigação) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Projetos

Projeto

Designação Financiadores
2023/10/03 - Atual Changeing the gut-adipose tissue axis: Mediterranean Diet on enteroendocrine and AT endothelial cells communication
101087071
Bolseiro de Doutoramento
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Horizon Europe
Em curso
2023/05/03 - 2023/09/30 New THerapeutIc strategies for obesity based oN peripheral dopamiNERgic signalling
2022.05822.PTDC
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Em curso
2021/09 - 2021/09 (BII19): New Metabolic Therapies for Diabetes: CAPEOSBAC - Tailored microenCAPsulation technology for Extreme Oxygen-Sensitive BACteria with beneficial effects on gut microbiota
4539
Bolseiro de Iniciação Científica
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Amaro, Andreia; Sousa, Diana; Sá-Rocha, Mariana; Ferreira-Junior, Marcos Divino; Rosendo-Silva, Daniela; Saavedra, Lucas Paulo Jacinto; Barra, Cátia; et al. "Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes". Nutrients 15 16 (2023): 3581. http://dx.doi.org/10.3390/nu15163581.
    10.3390/nu15163581
  2. Sousa, Diana; Rocha, Mariana; Amaro, Andreia; Ferreira-Junior, Marcos Divino; Cavalcante, Keilah Valéria Naves; Monteiro-Alfredo, Tamaeh; Barra, Cátia; et al. "Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models". Nutrients 15 5 (2023): 1281. http://dx.doi.org/10.3390/nu15051281.
    Publicado • 10.3390/nu15051281
  3. Amaro, Andreia; Sousa, Diana; Sá-Rocha, Mariana; Ferreira-Júnior, Marcos D.; Barra, Cátia; Monteiro, Tamaeh; Mathias, Paulo; et al. "Sex-specificities in offspring neurodevelopment and behaviour upon maternal glycation: Putative underlying neurometabolic and synaptic changes". Life Sciences (2023): 121597. http://dx.doi.org/10.1016/j.lfs.2023.121597.
    10.1016/j.lfs.2023.121597
  4. Sousa, Diana; Lopes, Eduardo; Rosendo-Silva, Daniela; Matafome, Paulo. "The Bidirectional Relationship of NPY and Mitochondria in Energy Balance Regulation". Biomedicines 11 2 (2023): 446. http://dx.doi.org/10.3390/biomedicines11020446.
    Publicado • 10.3390/biomedicines11020446
Resumo em conferência
  1. Sousa, Diana; AMARO, ANDREIA; Mariana Rocha; Ferreira Junior, Marcos Divino; Barra, Cátia; Mello-Gomes, Rodrigo; Matafome, Paulo. "The dysregulation of energy balance crosstalk between the hypothalamus and the brown adipose tissue in overfed rats exposed to maternal glycation". Trabalho apresentado em 59 th EASD Annual Meeting of the European Association for the Study of Diabetes, Hamburg, 2023.
    Publicado
  2. AMARO, ANDREIA; Sousa, Diana; Mariana Rocha; Ferreira Junior, Marcos Divino; Saavedra, Lucas Paulo Jacinto; Barra, Cátia; Baptista, Filipa I.; Matafome, Paulo. "Postnatal overfeeding triggers sex-specific neurodevelopmental delay and induces anxious-like behaviour accompanied by brain-region-specific synaptic imbalance". Trabalho apresentado em 59 th EASD Annual Meeting of the European Association for the Study of Diabetes, Hamburg, 2023.
    Publicado
  3. Sousa, Diana; Amaro, A; Ferreira Junior, Marcos Divino; Pereira, Susana P.; Mariana Rocha; Barra, Cátia; Mello-Gomes, Rodrigo; J Paulo Oliveira; Matafome, Paulo. "Sexual dimorphism in the modulation of energy balance in adipose tissue induced by exposure to obesogenic environments". Trabalho apresentado em 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, 2023.
    Publicado
  4. Amaro, A; Mariana Rocha; Sousa, Diana; Ferreira Junior, Marcos Divino; Saavedra, Lucas Paulo Jacinto; Mello-Gomes, Rodrigo; Baptista, Filipa I.; Matafome, Paulo. "Postnatal overweight- induced offspring neurodevelopment and behaviour alterations associated with synaptic imbalance, according to sex-specific vulnerabilities". Trabalho apresentado em 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, 2023.
    Publicado
  5. Sousa, Diana; Amaro, A; Ferreira Junior, Marcos Divino; Susana P. Pereira; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo; Matafome, Paulo. "Exposure to obesogenic environments during perinatal development modulates offspring nutrient sensing pathways in adipose tissue". Trabalho apresentado em 58th European Association for the Study of Diabetes Annual Meeting, Stockholm, 2022.
    Publicado
  6. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira Junior, Marcos Divino; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Mello-Gomes, Rodrigo; Baptista, Filipa I.; Matafome, Paulo. "Neurometabolic and behavioural alterations in the adolescent offspring upon maternal glycation". Trabalho apresentado em 58th European Association for the Study of Diabetes Annual Meeting, Stockholm, 2022.
    Publicado
  7. Sousa, Diana; Amaro, A; Ferreira Junior, Marcos Divino; Susana P. Pereira; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo; Matafome, Paulo. "Exposure to obesogenic environments during perinatal development modulates offspring nutrient sensing pathways in adipose tissue.". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022.
    Publicado
  8. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira Junior, Marcos Divino; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Mello-Gomes, Rodrigo; Baptista, Filipa I.; Matafome, Paulo. "Neurometabolic and behavioural alterations in the adolescent offspring upon maternal glycation.". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022.
    Publicado
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/03/09 O sistema npy/melanocortina é alterado pela sobrealimentação pós-natal em várias regiões do cérebro, estando associado a alterações comportamentais específicas de cada sexo 20º Portuguese Diabetes Congress
Portuguese Society of Diabetes (Vilamoura, Portugal)
2024/03/07 Interação periférica entre o sistema dopaminérgico e melanocortinérgico como potencial alvo terapêutico para a desregulação metabólica associada à obesidade 20º Portuguese Diabetes Congress
Portuguese Society of Diabetes (Vilamoura, Portugal)
2023/10/05 The dysregulation of energy balance crosstalk between the hypothalamus and the brown adipose tissue in overfed rats exposed to maternal glycation 59 th EASD Annual Meeting of the European Association for the Study of Diabetes
European Association for the Study of Diabetes (Hamburg, Alemanha)
2023/09/05 Postnatal overfeeding triggers sex-specific neurodevelopmental delay and induces anxious-like behaviour accompanied by brain-region-specific synaptic imbalance 59 th EASD Annual Meeting of the European Association for the Study of Diabetes
European Association for the Study of Diabetes (Hamburg, Alemanha)
2023/06/07 Sexual dimorphism in the modulation of energy balance in adipose tissue induced by exposure to obesogenic environments 57th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Prague, República Checa)
2023/03/17 Mecanismos compensatórios de balanço energético induzidos por sobrepeso pós-natal são prejudicados em condições maternas não saudáveis 19th Portuguese Diabetes Congress
Portuguese Society of Diabetes (Vilamoura, Portugal)
2023/02/03 Neurometabolic and behavioral alterations in the adolescent offspring upon maternal glycation 53rd Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2023/02 Obesogenic environments exposure during perinatal development modulates energy balance in the adipose tissue of newborns 53rd Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2022/09 Exposure to obesogenic environments during perinatal development modulates offspring nutrient-sensing pathways in adipose tissue 58th European Association for the Study of Diabetes Annual Meeting
European Association for the Study of Diabetes (Stockholm, Suécia)
2022/09 Neurometabolic and behavioral alterations in the adolescent offspring upon maternal glycation 58th European Association for the Study of Diabetes Annual Meeting
European Association for the Study of Diabetes (Stockholm, Suécia)
2022/06 Exposure to obesogenic environments during perinatal development modulates offspring nutrient-sensing pathways in adipose tissue. 56th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Bari, Itália)
2022/06 Neurometabolic and behavioural alterations in the adolescent offspring upon maternal glycation. 56th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Bari, Itália)
2022/03 O desenvolvimento perinatal em ambientes obesogénicos provoca alterações nas vias de sensibilidade aos nutrientes 18th Portuguese Diabetes Congress
Portuguese Society of Diabetes (Vilamoura, Portugal)
2022/03 Maternal glycation accelerates neurodevelopment in offspring, inducing metabolic changes and less anxious behavior in adolescence 18th Portuguese Diabetes Congress
Portuguese Society of Diabetes (Vilamoura, Portugal)
2022/03 Hypercaloric maternal diet during pregnancy and lactation and development of insulin resistance: role of dietary glycotoxins 18th Portuguese Diabetes Congress
Portuguese Society of Diabetes (Vilamoura, Portugal)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2018/02/15 - Atual Attendance at lectures Session 2 of “Conversations with Ethics” – “CRISPR – copy --- paste de ADN. The new technologies of Genetic Engineering”
Universidade de Coimbra Faculdade de Medicina, Portugal
2023/01/12 - 2023/01/13 Attendance at lectures and volunteer to assist the organization committee
Encontro
 III Meeting of Metabolism, Aging and Disease (MAD) of CIBB
Centre for Innovative Biomedicine and Biotechnology (CIBB), Portugal
2021/11/17 - 2021/11/18 Attendance at lectures II Meeting of Metabolism, Aging and Disease (MAD) of CIBB
Center for Innovative Biomedicine and Biotechnology (CIBB), Portugal
2020/05 - 2020/05 Attendance at lectures
Seminário
 Bioeconomy for a Sustainable Future
Universidade de Coimbra, Portugal
2020/02/14 - 2020/02/16 Participation at the I University Biochemistry Olympics, obtaining the 10th place at national level Participation in workshops and lectures
Seminário
 I University Biochemistry Olympics
Universidade de Coimbra, Portugal

Expedição científica

Descrição da atividade Instituição / Organização
2022/02/08 - 2022/02/08 Escola Ciência Viva - "What we eat" for children aged 3 to 6 Center for Innovative Biomedicine and Biotechnology (CIBB), Portugal

Membro de associação

Nome da associação Tipo de participação
2022 - Atual Portuguese Society of Diabetology
2022 - Atual European Society for Clinical Investigation
2022 - Atual European Association for the Study of Diabetes