Sandra Isabel Freitas Mota (6E1C-E9CD-7E7D)

Curriculum Vitae

Sandra Isabel Freitas Mota

Sandra Mota graduated in Biomedical Biochemistry in 2006 at the Université René Descartes in Paris and completed her formation on the same university by a Master on Pharmacology and Toxicology, with a large component of oncology, under the supervision of Doctor Robert Baroukis's laboratory (INSERM U747), evaluating the effect of dioxine and alcohol on hepatocarcinoma progression. In 2013, she obtained a PhD degree (Cellular Biology) by the Faculty of Sciences and Technology of Coimbra, working on the importance of NMDA Receptors for early Alzheimer's disease progression at the Center for Neurosciences and Cell Biology (CNC, University of Coimbra), under the supervision of the Doctor AC Rego. She obtained a post-doctoral fellowship in 2014 from the Portuguese Foundation for the Science and Technology (FCT) to work on oxidative stress-associated pathways in Alzheimer's disease under the main supervision of Doctor AC Rego. Since 2019, she is a hired researcher at the CNC under the DL57/2016 of the Portuguese law for scientific and technological employment. During 8 years after the conclusion of her PhD, Sandra Mota has evaluated the role of mitochondrial dysfunction and glutamatergic post synapse impairment as early events in neurodegenerative disorders such as Alzheimer' and Huntington's disease. In 2021, she moved to the group Metabolism, Aging and Disease, leaded by Doctor PJ Oliveira at CNC, where she applied her know-how on mitochondrial metabolism and neuronal function to participate in several projects on oncology and neurosciences. Sandra Mota holds an H factor of 12 and more than 800 citations, published 20 peer-reviewed articles (14 original publications), 1 book chapter and more than 70 abstracts in research meetings. Sandra Mota also collaborated in the supervision of several undergraduate and master students (among them: 1 master as supervisor and 2 as co-supervisor) and co-supervised the work of 3 Ph.D. students (1 completed and 2 ongoing). Sandra has also been enrolled in several teaching activities and has also been actively engaged with the science communication office and "Ciência Viva" at the Laboratory in programs for public outreach. Sandra Mota is a reviewer for scientific journals (Neural Regeneration Research and OBM Neurobiology) and guest editor in Cells and Methods Collections at JoVE, and is a member of the Portuguese Society for Neurosciences since 2012. She is also founding member of the GreenLabCIBB initiative which promotes a sustainable research to reduce the ecological footprint. In 2019 Sandra had a career break for five months due to maternity leave.

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Identificação

Identificação pessoal

Nome completo: Sandra Isabel Freitas Mota

Nomes de citação

Mota, Sandra
Mota Sandra I.
Mota, S.I.

Identificadores de autor

Ciência ID: 6E1C-E9CD-7E7D
ORCID iD: 0000-0001-9623-5012

Endereços de correio eletrónico

sandra.mota@cnc.uc.pt (Profissional)

Moradas

Centro de Neurosciências e Biologia Celular. University of Coimbra, Rua Larga, 3004-517, Coimbra, Coimbra, Portugal (Profissional)

Websites

http://www.cnbc.pt/research/department_group_show.asp?iddep=1107&idgrp=1108 (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Francês (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2013/05/09 Concluído	Cellular Biology (Doutoramento) Especialização em Neurosciences Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "NMDA receptors-associated events and oxidative stress in models of Alzheimer’s disease" (TESE/DISSERTAÇÃO)	Doutorada com Louvor e Distinção
2008 Concluído	Life and Health Sciences (Mestrado) Especialização em Drug Sciences Domain, Specialty in Cellular Biology and Pharmacology Faculty of Pharmacy, University René Descartes of Paris, França "Implication of alcohol and CYP 2E1 in liver fibrosis and hepatocarcinoma" (TESE/DISSERTAÇÃO)	Bom
2006 Concluído	Life Sciences (Licenciatura) Especialização em Biomedical Chemistry, Biology and Physic Faculty of Fundamental Science and Biomedicine, University René Descartes of Paris, França "n/a" (TESE/DISSERTAÇÃO)	Bom

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2019/04/01 - Atual	Investigador Contratado (Investigação)	CNC.IBILI, Portugal
	CNC.IBILI, Portugal
2013/05/13 - 2019/03/31	Pós-doutorado (Investigação)	CNC.IBILI, Portugal
	CNC.IBILI, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2008/09/01 - 2013/05/08	PhD student	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/10/01 - 2008/07/31	Master student	Toxicité Environnementale Cibles Thérapeutiques Signalisation Cellulaire et Biomarqueurs, França
	Université de Paris, França

Projetos

Bolsa

	Designação	Financiadores
2014 - 2019	H2O2-mediated Src signaling pathways in glutamatergic synapses in Alzheimer's disease models SFRH/BPD/99219/2013 Bolseiro de Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009/01/01 - 2012/12/31	NMDA receptors-associated events and oxidative stress in models of Alzheimer’s disease SFRH/BD/43430/2008 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2022/01/15 - Atual	Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis PTDC/BTM-ORG/0055/2021 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/10/01 - Atual	Organelle-targeted Radiocomplexes for Auger Therapy of Cancer Radiocomplexos Dirigidos a Organelos Celulares para Terapia Auger do Cancro PTDC/MED-QUI/1554/2020 Investigador Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - Atual	Projeto Estratégico Centro de Inovação em Biomedicina e Biotecnologia UIDP/04539/2020 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01 - Atual	Projeto Estratégico Centro de Inovação em Biomedicina e Biotecnologia UIDB/04539/2020 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07 - 2021/03/31	Transcriptional activity modulation in Alzheimer's disease by inhibitors of histone deacetylases POCI-01-0145-FEDER-032316 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2014/01 - 2016/02	Evaluation of oxidative stress and mitochondrial dysfunction in animal models and patients of Huntington’s disease using Cu(II)-ATSM PET N/A Bolseiro de Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Santa Casa da Misericórdia de Lisboa Concluído
2011/10 - 2014/12	Genetic susceptibility of multisystemic complications of diabetes type 2: novel biomarkers for diagnosis and monitoring of therapy Do-IT “DIAMARKER PROJECT” Bolseiro de Doutoramento Universidade de Coimbra Faculdade de Medicina, Portugal	Quadro de referência Estratégica Nacional Concluído
2009/03 - 2011/02	Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine N/A Bolseiro de Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	H. Lundbeck A/S Concluído
2008/09/01 - 2010/12	Contribution of N-methyl-D-aspartate receptors subunits to neuronal dysfunction in Alzheimer’s disease PTDC/SAU-NEU/71675/2006 Bolseiro de Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/10/01 - 2008/08/31	Polluants Organiques persistants (POP)_ Migration cellulaire et progression tumorale – ONCOPOP ANR-02-ESTE-0026 Bolseiro de Mestrado INSERM Délégation Régionale Paris 5, França	Agence nationale de la recherche Concluído

Outro

	Designação	Financiadores
2018/05 - 2019/04	Action of carnitines on mitochondrial function in rat hippocampal neurons exposed to oligomers of amyloid-beta peptide N/A Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Sigma-Tau B.V. Company Concluído
2018/01/01 - 2018/05	Exploring the role of pridopidine on mitochondrial function and dynamics in Huntington’s disease models N/A Bolseiro de Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	TEVA pharmaceuticals industries ltd. Concluído
2017 - 2017	Supplementation of Coriolus versicolor (biomass) - a nutritional presymptomatic approach against cognitive deficits N/A Bolseiro de Pós-Doutoramento	Mycology Research Laboratories (MRL) Ltd. Concluído

Produções

Publicações

Artigo em jornal	Mota, S.I.. ""Viagens no Cérebro" ("Travel in the brain") _ comic brochure", O Público, 2017
Artigo em revista	Cavaleiro, Carla; Afonso, Gonçalo J. M.; Oliveira, Paulo J.; Valero, Jorge; Mota, Sandra I.; Ferreiro, Elisabete. "Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions". Frontiers in Molecular Neuroscience 16 (2023): http://dx.doi.org/10.3389/fnmol.2023.1229728. 10.3389/fnmol.2023.1229728 Sandra I. Mota; Lígia Fão; Patrícia Coelho; A. Cristina Rego. "Uncovering the Early Events Associated with Oligomeric Aß-Induced Src Activation". Antioxidants (2023): https://doi.org/10.3390/antiox12091770. 10.3390/antiox12091770 Gonçalo J. M. Afonso; Carla Cavaleiro; Jorge Valero; Sandra I. Mota; Elisabete Ferreiro. "Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives". Cells (2023): https://doi.org/10.3390/cells12131763. 10.3390/cells12131763 Lopes, Carla; Ferreira, I. Luísa; Maranga, Carina; Beatriz, Margarida; Mota, Sandra I.; Sereno, José; Castelhano, João; et al. "Mitochondrial and redox modifications in early stages of Huntington's disease". Redox Biology 56 (2022): 102424. http://dx.doi.org/10.1016/j.redox.2022.102424. 10.1016/j.redox.2022.102424 Cláudia Deus; Deus, CM; Henrique Tavares; Margarida Beatriz; Sandra Mota; C Lopes. "Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders". Cells 11 15 (2022): 2364-2364. http://dx.doi.org/10.3390/cells11152364. 10.3390/cells11152364 Fão L; Coelho P; Duarte L; Vilaça R; Hayden M; Mota S; Rego AC. "Restoration of c-Src/Fyn proteins rescues mitochondrial dysfunction in Huntington's Disease.". Antioxidants & redox signaling (2022): http://europepmc.org/abstract/med/35651273. 10.1089/ars.2022.0001 Coelho P; Fão L; Mota S; Rego AC. "Mitochondrial function and dynamics in neural stem cells and neurogenesis: Implications for neurodegenerative diseases.". Ageing research reviews (2022): http://europepmc.org/abstract/med/35714855. 10.1016/j.arr.2022.101667 Geva M; Gershoni-Emek N; Naia L; Ly P; Mota S; Rego AC; Hayden MR; Levin LA. "Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma.". Scientific reports (2021): http://europepmc.org/abstract/med/34753986. 10.1038/s41598-021-01077-w Sandra I. Mota; Inês Pita; Rodolfo Águas; Slah Tagorti; Ashraf Virmani; Frederico C. Pereira; A. Cristina Rego. "Mechanistic perspectives on differential mitochondrial-based neuroprotective effects of several carnitine forms in Alzheimer’s disease in vitro model". Archives of Toxicology 95 8 (2021): 2769-2784. https://doi.org/10.1007/s00204-021-03104-1. 10.1007/s00204-021-03104-1 Mota, S.I.; Naia Luana; Philip Ly; Carla Maria Nunes Lopes; Maranga, Carina; Patrícia Coelho; Noga Gershoni-Emek; et al. "The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models.". Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2021): https://doi.org/10.1007/s13311-021-01022-9. Aceite para publicação • 10.1007/s13311-021-01022-9 Ferreiro, Elisabete; Lanzillo, Mariagrazia; Canhoto, Diogo; Carvalho da Silva, António M.; Mota, Sandra I.; Dias, Inês S.; Ferreira, Ildete L.; et al. "Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model". Neurobiology of Aging 92 (2020): 98-113. http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.003. 10.1016/j.neurobiolaging.2020.04.003 Fão, Lígia; Mota, Sandra; Rego, Ana Cristina. "Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases.". Ageing research reviews (2019): http://europepmc.org/abstract/med/31415806. 10.1016/j.arr.2019.100942 Fão, Lígia; Mota, Sandra I.; Rego, A. Cristina. "c-Src regulates Nrf2 activity through PKCd after oxidant stimulus". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866 4 (2019): 686-698. http://dx.doi.org/10.1016/j.bbamcr.2019.01.011. 10.1016/j.bbamcr.2019.01.011 Ferreiro E; Pita IR; Mota SI; Valero J; Ferreira NR; Fernandes T; Calabrese V; et al. "Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus.". Oncotarget (2018): http://europepmc.org/abstract/med/30250640. 10.18632/oncotarget.25978 Mota, S.I.; Costa, R.O.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS. 10.1016/j.bbadis.2015.03.015 Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C.; et al. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway". Experimental Neurology 261 (2014): 698-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS. 10.1016/j.expneurol.2014.07.023 Mota, S.I.; Ferreira, I.L.; Rego, A.C.. "Dysfunctional synapse in Alzheimer's disease - A focus on NMDA receptors". Neuropharmacology 76 PART A (2014): 16-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886641553&partnerID=MN8TOARS. 10.1016/j.neuropharm.2013.08.013 Ferreira, I.L.; Bajouco, L.M.; Mota, S.I.; Auberson, Y.P.; Oliveira, C.R.; Rego, A.C.. "Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures". Cell Calcium 51 2 (2012): 95-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856958510&partnerID=MN8TOARS. 10.1016/j.ceca.2011.11.008 Mota, S.I.; Ferreira, I.L.; Pereira, C.; Oliveira, C.R.; Rego, A.C.. "Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures". Current Alzheimer Research 9 7 (2012): 844-856. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866468436&partnerID=MN8TOARS. 10.2174/156720512802455322 Bui, L.-C.; Tomkiewicz, C.; Chevallier, A.; Pierre, S.; Bats, A.-S.; Mota, S.; Raingeaud, J.; et al. "Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity". Oncogene 28 41 (2009): 3642-3651. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350066363&partnerID=MN8TOARS. 10.1038/onc.2009.224
Capítulo de livro	Ferreira IL; Carmo C; Naia L; I Mota S; Cristina Rego A. "Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington's Disease.". In Huntington’s Disease; Part of the Methods in Molecular Biology book series, 415-442. Sophie V. Precious; Anne E. Rosser; Stephen B. Dunnett, 2018. Publicado • 10.1007/978-1-4939-7825-0_19
Poster em conferência	Margarida Sobral; Joana Santos; Raposinho, Paula; Fernandes, Célia; Mendes, Filipa; Sandra Mota;Paulo Oliveira; António. "Design, synthesis and evaluation as theranostics agents of novel metalloconjugates targeted at the mitochondria of prostate cells". Trabalho apresentado em Ambiente, genética e oncobiologia no século XX! – desafios e Oportunidades, CIMAGO, Coimbra, Portugal., 2024. Valente P A; Ferreiro F; Mota Sandra I.; Rama L; Teixeira A; Cipriano I; Azevedo N; Oliveira PJ. "Comparing VO2max and UDSC oxygen consumption rates for use in sports physiology.". Trabalho apresentado em Mitochondria in Aging, Cancer and Cell Death 2023, 2023. Margarida Sobral; Joana Santos; Fernandes, Célia; Raposinho, Paula; Mendes, Filipa; Sandra Mota;Paulo Oliveira; António. "Biological e valuation of novel dually target ed metalloconjugates containing a PSMA inhibitor and a TPP group for prostate cancer theranostics". Trabalho apresentado em Mitochondria in Aging, Cancer and Cell Death 2023. Coimbra, Portugal,, 2023. Mendes C; Marques C; Mota Sandra I.; et al.. "Green Labs @CIBB: “Collection Points” – Reuse and Recycling". Trabalho apresentado em Green Labs Portugal Symposium: Promoting sustainability in Research, 2023. B. Santos et al. "GreenLabsCIBB - One path for sustainable research". Trabalho apresentado em Green Labs Portugal Symposium: Promoting sustainability in Research, 2023. Margarida Sobral; Joana Santos; Fernandes, Célia; Mendes, Filipa; Raposinho, Paula; Ana M.Urbano; Sandra Mota; Paulo. "Avaliação biológica em modelos celulares de cancro da próstata de radioconjugados de duplo alvo contendo um grupo trifenil-fosfónio (TPP) e um inibidor do PSMA". Trabalho apresentado em 5º Encontro Nacional de Jovens Investigadores em Oncologia, Porto Portugal, 2023. S. Alarico; M Afonso; A Alves; S Amaral; R Amorim; E Candeias; M Cardoso; et al. "GreenLabsCiBB: One path for sustainable research.". Trabalho apresentado em EU-LIFE 10th Anniversary Conference. Calouste Gulbenkian Foundation., 2023. Margarida Sobral; Joana Santos; Fernandes, Célia; Mendes, Filipa; Raposinho, Paula; Ana M.Urbano; Sandra Mota; Paulo. "Dually-targeted radioconjugates carrying TPP and a PSMA-binding moiety: biologicalstudies in prostate cancer models". Trabalho apresentado em 57th AnnualScientific Meeting of the European Society for Clinical Investigation, Prague, Czech Republic, 2023. Margarida Sobral; Joana Santos; Fernandes, Célia; Raposinho, Paula; Mendes, Filipa; Ana M.Urbano; Sandra Mota; Paulo. "Biological evaluation ofdual-targeted radioconjugates carrying TPP and PSMA-binding moieties onprostate cancer models". Trabalho apresentado em 1st FEBS Redox MedicineWorkshop: from cellular signaling to systems physiology and therapeutictargets,, 2023. Gabriela L. Oliveira ; Ana Vieira-Pedrosa; Mota Sandra I.; Paulo J Oliveira ; Ricardo Marques. "Adenine Nucleotide Translocase 2 Role in the Metabolic Profile and Matrix Detachment of P19 Embryonal Carcinoma Stem Cells". Trabalho apresentado em 56th Annual Scientific Meeting of the ESCI, 2022. Michal Geva; Marina Shenkman; Luana Naia; Philip Ly; Mota, S.I.; Lopes, Carla; Maranga, Carina; et al. "Amelioration of ER stress and restauration of mitochondrial function contribute to the neuroprotective effects of pridopidine in HD neurons.". Trabalho apresentado em 15 th Annual Huntington’s disease Therapeutics Conference, 2020. Fão, Lígia; Mota, S.I.; Rego, Ana Cristina. "c-Src/Fyn role in Huntington’s Disease progression". Trabalho apresentado em 23rd Annual Meeting of the Portuguese Society of Human Genetics, 2019. Michal Geva; Luana Naia; Philip Ly; Mota, S.I.; Lopes, Carla; Maranga, Carina; Michael R. Hayden; Rego, Ana Cristina Rego. "Pridopidine rescues multiple mitochondrial functions impaired in human and mice HD models by activation of the Sigma-1 receptor.". Trabalho apresentado em HSG 2019 – Huntington Study Group Annual Meeting., 2019. Ferreiro, Elisabete; Lanzillo M; Mota, S.I.; Canhoto D; Silva A. M; Dias S.I; Ferreira, I.L.; et al. "Chronic hyperglycemia impairs hippocampal neurogenic reserve and memory in an alzheimer’s disease mouse model". Trabalho apresentado em ADPD 2019, 2019. Mota, S.I.; Fão, Lígia; Rego, A. Cristina. "Amyloid-beta 1-42 oligomers-induced mitochondrial changes in hippocampal neuritis – Involvement of NMDA receptors and Src family kinases.". Trabalho apresentado em ADPD 2019, 2019. Luana Naia; Philipe Ly; Mota, S.I.; Lopes, Carla; Maranga, Carina; Michal Geva; Michael R. Hayden; Rego, Ana Cristina. "Pridopidine preserves mitochondrial morphofunction in in vitro and ex vivo Huntington’s disease models through Sigma-1 receptor-dependent decrease in oxidative stress.". Trabalho apresentado em AD/PD 2019 –Alzheimer’s and Parkinson’s Diseases International Meeting, 2019. Fão, Lígia; Mota, S.I.; Rego, Ana Cristina. "Regulation of Nrf2 activity by Src Kinase Family and PKC after an oxidant stimulus". Trabalho apresentado em Sinal 2018, 2018. Mota, S.I.; Fão, Lígia; Rego, Ana Cristina. "Oligomeric amyloid-beta peptide-induced redox dendritic mitochondrial changes in mature hippocampal neurons: role of NMDA receptors and Src kinase". Trabalho apresentado em MitoPorto International Symposium,, 2018. Rego, Ana Cristina; Ferreiro, Elisabete; Pita IR; Mota, S.I.; Valero, Jorge; Ferreira NR; Fontes-Ribeiro CA; et al. "Enhanced complexity of hippocampal dentate gyrus newly-generated neurons in mice following Coriolus versicolor biomass administration". Trabalho apresentado em FENS 2018, 2018. Pereira FC; Ferreiro, Elisabete; Pita IR; Mota, S.I.; Valero, Jorge; Ferreira NR; Fontes-Ribeiro CA; et al. "Coriolus Versicolor biomass increases hippocampal dentate gyrus newly-generated neurons complexity in mice". Trabalho apresentado em World Congress of basic and clinical Pharmacology, 2018. Mota, S.I.; Fão, Lígia; Rego, Ana Cristina. "NMDA receptor-dependent redox changes and modified dendritic mitochondria following exposure to oligomeric amyloid-beta peptide in mature hippocampal neurons". Trabalho apresentado em MitoPorto International Symposium,, 2017. Fão, Lígia; Mota, S.I.; Rego, Ana Cristina. "Crosstalk between Src kinase and Nrf2 following oxidant stimulus - mitochondria and nucleus as relevant subcellular targets". Trabalho apresentado em MitoPorto International Symposium, 2017. Ferreira, IL; Maranga, Carina; Mota, S.I.; Laço M; Sereno, José Vitor Oliveira; Abrunhosa, Antero; Hayden M; Castelo-Branco, Miguel; Rego, Ana Cristina. "Redox and mitochondrial functional switches in striatum and cortex of pre-symptomatic and symptomatic Huntington’s disease mouse model". Trabalho apresentado em XIX National Congress of Biochemistry by the Portuguese Society of Biochemistry, 2016. Rego, Ana Cristina; Ferreira, IL; Maranga, Carina; Laço Mário; Mota, S.I.; Naia Luana; Sereno, José Vitor Oliveira; et al. "Redox changes and bioenergetic defects in striatum and cortex of pre-symptomatic and symptomatic Huntington disease mice.". Trabalho apresentado em 46th Annual Meeting of Society for Neuroscience (SFN), 2016. Fão, Lígia; Mota, S.I.; Rego, Ana Cristina. "Induction of oxidative stress by amyloid-beta1-42 in mature hippocampal neurons: linking Src activity to Alzheimer’s disease.". Trabalho apresentado em XL Jornadas Portuguesas de Genética,, 2016. Mota, S.I.; Fão, Lígia; Rego, Ana Cristina. "Role of Src kinase in oligomeric amyloid-beta-induced early oxidative stress in mature hippocampal neurons –a link to Alzheimer’s disease pathogenesis". Trabalho apresentado em 7th ISN 2016 Special Neurochemistry Conference, 2016. Mota, S.I.; Laço M; Maranga, Carina; de Rosa M; Ferreira, IL; Rego, Ana Cristina. "Age-dependent oxidative stress in presynaptic terminals of a mouse model of Huntington’s disease.". Trabalho apresentado em 7th ISN 2016 Special Neurochemistry Confrence, 2016. Maranga, Carina; de Rosa, M; Laço, M.L.; Mota, S.I.; Ferreira, I.L.; Rego, Ana Cristina. "Altered oxidative stress-related proteins in Huntington’s disease YAC128 mouse model.". Trabalho apresentado em XIII CNC Annual Meeting,, 2015. Laço, M.L.; Mota, S.I.; Maranga, Carina; Ferreira, I.L.; Rego, Ana Cristina. "Redox deregulation in Huntington’s disease YAC128 transgenic mousse model is unrelated to mitochondrial dysfunction". Trabalho apresentado em XIII CNC Annual Meeting, Portugal, 2015. Ferreiro, Elisabete; Lanzillo M; Silva A.M.; Mastrella, G; Mota, S.I.; Fontes, A.R.; Ferreira, I.L.; et al. "Effect of chronic hyperglycemia on newly-generated neurons maturation and memory in a transgenic mouse model of Alzheimer’s disease.". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neuroscience, 2015. Ferreiro, Elisabete; Lanzillo M; Silva, A.M.; Mastrella, G; Mota, S.I.; Fontes, A.R; Ferreira, I.L.; et al. "Linking impairment of hippocampal neurogenesis and memory loss in a diabetic-like Alzheimer’s disease mouse model.". Trabalho apresentado em Adult Neurogenesis: Evolution, Regulation and Function, 2015. Laço, ML; Mota, S.I.; Ferreira, I.L.; Rego, Ana Cristina. "Hydrogen peroxide production increases with Huntington’s disease progression in brains of YAC128 transgenic animal mode". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014. Ferreiro, Elisabete; Lanzillo M; Silva, A.M.; Mastrella, G.; Mota, S.I.; Fontes, A.R.; Ferreira, I.L.; et al. "Impaired memory in a transgenic mouse model of Alzheimer’s disease under hyperglycemia – a link to reduced hippocampal neurogenesis?". Trabalho apresentado em XII CNC Annual Meeting, 2014. Ferreira, I.L.; Ferreiro, Elisabete; Mota, S.I.; Cardoso, J.M.; Pereira, Cláudia Maria Pereira; Oliveira, C.R.; Rego, Ana Cristina. "In situ mitochondrial dysfunction evoked by immediate exposure to amyloid-beta 1-42 and NMDA receptor activation involving calcium release from endoplasmic reticulum". Trabalho apresentado em XIII Annual Meeting of the Portuguese Society for Neurosciences, 2013. Mota, S.I.; Costa, R.O.; Caldeira, G.L.; Santana, Isabel; Padovano, C.; Fonseca, A.C.; Letra, Liliana; et al. "Oxidative and endoplasmic reticulum stress in early stages of Alzheimer’s disease". Trabalho apresentado em X CNC Annual Meeting, 2012. Mota, S.I.; Costa, R.O.; Caldeira, G.L.; Santana, Isabel; Padovano, C.; Fonseca, A.C.; Letra, Liliana; et al. "Nrf2 downregulation-mediated oxidative stress and ER stress in early stages of Alzheimer’s disease". Trabalho apresentado em Meeting Cold Spring Harbor- New York, United States, 2012. Mota, S.I.; Ferreira, I.L.; Ferreiro, Elisabete; Pereira, Cláudia Maria Pereira; Oliveira, C.R.; Rego, Ana Cristina. "Age and gender-dependent modifications in NMDA receptor subunits in the cortex and hippocampus of Alzheimer’s disease transgenic mice". Trabalho apresentado em 8th FENS Forum of Neuroscience, 2012. Ferreira, I.L.; Mota, S.I.; Bajouco, Miguel; d'Amati, C.; Oliveira, C.R.; Rego, Ana Cristina. "Involvement of NR2B subunit in amyloid-beta peptide-induced calcium rise and ROS in rat cortical neurons". Trabalho apresentado em 8th FENS Forum of Neuroscience, 2012. Mota, S.I.; Costa, R.O; Santana, Isabel; Padovano, C; Fonseca, A.C.; Caldeira, G.L.; Letra, Liliana; et al. "Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease". Trabalho apresentado em 26ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, 2012. Rego, Ana Cristina; Mota, S.I.; Ferreira, I.L.; Oliveira, C.R.; Pereira, Cláudia Maria Pereira. "Age-dependent NMDA receptor subunit composition and activation in Alzheimer’s disease females and males 3xTg-AD mice". Trabalho apresentado em XII Meeting of the Portuguese Neuroscience Society, 2011. Fonseca, A.C.; Ferreira, I.L.; Costa, R.O.; Mota, S.I.; Padovano, C; Letra, Liliana; Oliveira, C.R.; et al. "Increased susceptibility to cell death following early peripheral endoplasmic reticulum and oxidative stress in Alzheimer’s disease patients". Trabalho apresentado em SINAL2011, 5th Annual Meeting on Cell Signalling, 2011. Mota, S.I.; Ferreira, I.L.; Pereira, Cláudia Maria Pereira; Oliveira, C.R.; Rego, Ana Cristina. "Brain cortical changes in NMDA receptor subunit expression and activation in Alzheimer’s disease". Trabalho apresentado em SINAL2011, 5th Annual Meeting on Cell Signalling, 2011. 10.1109/nanomed.2013.6766320 Mota, S.I.; Ferreira, I.L.; Pereira, Cláudia Maria Pereira; Oliveira, C.R.; Rego, Ana Cristina. "Amyloid-beta oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal neurons". Trabalho apresentado em 10th International Conference AD/PD, 2011. Ferreira, I.L.; Mota, S.I.; Costa, R.O.; Padovano, C; Fonseca, A.C.; Letra, Liliana; Oliveira, C.R.; et al. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Trabalho apresentado em 10th International Conference AD/PD, 2011. Rego, Ana Cristina; Ferreira, I.L.; Mota, S.I.; Bajouco, Miguel; Pereira, Cláudia Maria Pereira; Oliveira, C.R.. "Early intracellular calcium deregulation and microtubule disassembly induced by amyloid-beta 1-42 oligomers in primary cultured neurons role of NR2B receptor subunit". Trabalho apresentado em 7th FENS Forum of European Neuroscience, 2010. Mota, S.I.; Ferreira, I.L.; Oliveira, C.R.; Pereira, Cláudia Maria Pereira; Rego, Ana Cristina. "Alzheimer’s disease-associated amyloid-beta petide induces microtubule disassembly and DNA fragmentation in mature hippocampal neurons". Trabalho apresentado em Ciência 2010, 2010. Oliveira, C.R.; Ferreira, IL; Costa, R.O.; Mota, S.I.; Bajouco, Miguel; Lacor, P.N.; Klein, W.L.; Rego, Ana Cristina. "Binding of amyloid-beta oligomers to NR2B subunits is associated with endoplasmic reticulum stress in hippocampal neurons". Trabalho apresentado em 39th Annual Meeting of the American Society for Neuroscience, 2009. Ferreira, IL; Mota, S.I.; Bajouco, Miguel; Pereira, Cláudia Fragão; Oliveira, C.R.; Rego, Ana Cristina. "Role of NMDA receptor subunits NR2A and NR2B on neuronal dysfunction caused by oligomeric amyloid-beta peptide". Trabalho apresentado em Sociedade Portuguesa de Neurociências, 2009.
Tese / Dissertação	Mota, S.I.. "NMDA receptors-associated events and oxidative stress in models of Alzheimer's Disease". Doutoramento, 2013. http://hdl.handle.net/10316/23367.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/01/29	"Metalloconjugates designed totarget the mitochondria of prostate cancer cells: design, synthesis andevaluation as theranostic agents"	IV Metabolism,Ageing & Disease (MAD) Meeting Disease & Therapeutics: from the Past toFuture CIBB, University of Coimbra (Coimbra, Portugal)
2022/09/24	Radiocomplexes directed to subcellular organelles for anti-tumoral Auger therapy.	4º Portuguese National Meeting of Young Oncology Researchers. (porto, Portugal)
2021/02/18	MITOCHONDRIAL MODULATION BY DIFFERENT FORMS OF CARNITINE IN AN IN VITRO MODEL OF ALZHEIMER ´S DISEASE	Sociedade Portugues da Farmacologia Meeting 2021 SPF (Lisboa, Portugal)
2020/02/05	Pridopidine rescues mitochondrial function in human and mouse Huntington’s disease models through Sigma-1 receptor	50 th Meeting of Portuguese Pharmacology Society Portuguese Pharmacology Society (Porto, Portugal)
2019/10/19	Exploring the role of c-Src/Fyn tyrosine kinases in Huntington’s Disease.	10th Meeting on Signal Transduction. SINAL (Olhão, Algarve, Portugal)
2018/09/21	Role of NMDAR receptors and Src family kinases in amyloid-beta oligomers-induced mitochondrial changes in neurites	9th Meeting on Signal Transduction SINAL (Lisbon, Portugal)
2017/02/16	Src signaling in Alzheimer’s disease-associated oxidative stress	5th Portuguese Meeting in Bioengineering Portuguese Chapter of IEEE Engineering in Medicine & Biology Society (EMBS) (Coimbra, Portugal)
2017/02/02	Oxidative Stress and Src Signaling in Alzheimer’s Disease	XLVII Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Coimbra, Portugal)
2016/06/03	Bioenergetic defects in pre-symptomatic and symptomatic stages in Huntington’s disease YAC128 mouse model	XXXth Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Lisbon, Portugal)
2016/06/03	Oligomeric amyloid-beta-induced oxidative stress in mature hippocampal neurons: role of Src kinase	XXXth Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Lisbon, Portugal)
2016/02/04	Redox deregulation in pre-symptomatic and symptomatic stages of Huntington’s disease	XLVIth Annual Meeting of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Porto, Portugal)
2015/12/17	Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer’s disease	XIII CNC Annual Meeting Center for Neurosciences and Cell Biology of Coimbra, CNC (Coimbra, Portugal)
2014/06/27	Linking NMDA receptors and the reelin pathway in Alzheimer’s disease mice model	28th Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Aveiro, Portugal)
2013/05/30	Altered NMDA receptor and Src related signaling in Alzheimer’s disease	13ª Meeting of the Portuguese Society for Neurosciences Portuguese Society for Neurosciences (Luso, Portugal)
2013/05/30	Oxidative and ER stress in early stages of Alzheimer’s disease	13º Meeting of the Portuguese Society for Neurosciences Portuguese Society for Neurosciences (Luso, Portugal)
2013/05/05	Simultaneous exposure to amyloid-beta peptide and NMDA leads to mitochondrial calcium retention involving the release of calcium from the endoplasmic reticulum.	Mitochondria: from signaling to disease Cell Symposia (Lisbon, Portugal)
2012/06/29	Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease	26th Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Tomar, Portugal)
2011/06/03	Pathological changes detected in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease individuals	25th Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Tomar, Portugal)
2010/06/25	Changes in NMDA receptor subunits expression in 3xTg-AD mice and human peripheral blood cells	24ª Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Tomar, Portugal)
2010/06/25	Loss of endoplasmic reticulum calcium homeostasis in Alzheimer’s disease	24ª Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Tomar, Portugal)
2009/12/02	Amyloid-beta peptide oligomers induce early microtubule disassembly and mild degeneration in mature rat hippocampal neurons	XXVIII Reunião de Farmacologia Clínica e IX Reunião de Toxicologia Portuguese Society of Pharmacology (Porto, Portugal)
2009/06/26	Altered beta-tubulin III levels in mature hippocampal neurons exposed to oligomers of amyloid-beta peptide	23ª Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Luso, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2022/05/01 - Atual	Metabolic profiling and reversion of mitochondrial dysfunction in Amyotrophic lateral sclerosis patients: innovative application of human neuronal cells differentiated from urine-derived stem cells Coorientador	PhD in Biomedicine and Experimental Biology (Doutoramento) Universidade de Coimbra, Portugal
2022/01/01 - Atual	Potential of human neurons transdifferentiated from urine-derived stem cells for ALS precision medicine Coorientador de Carla Sofia Teixeira Cavaleiro	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra, Portugal
2017/01/01 - 2023/01/06	Role of c Src/Fyn kinases in Huntington’s disease pathology - Impact on neurites, myelination and mitochondrial function Coorientador de Lígia Vanessa Fão	Programa Doutoral das ciências a saúde (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/09/01 - 2022/09/29	TRAP1-p66Shc interplay in oxidative stress in lung cancer cells Orientador de Catarina Tavares Mendes	Master in Celular and Molecular Biology (Mestrado) Universidade de Coimbra, Portugal
2022/02/15 - 2022/07/22	Optimization of a cryopreservation protocol for urine-derived stem cells from ALS patients Coorientador de Daniel Costa	Engenharia Biomédica (Licenciatura/Bacharelato) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022/02/15 - 2022/07/15	Potential of human neurons transdifferentiated from urine-derived stem cells for ALS precision medicine Coorientador de Diogo Pato	Engenharia Biomédica (Licenciatura/Bacharelato) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022/05/02 - 2022/07/08	Evaluation of the interplay between TRAP1 and p66Shc proteins in oxidative stress in lung cancer Orientador	Licenciatura em Biotecnologia (Licenciatura/Bacharelato) Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2019/09/01 - 2021/02/24	Linking mitochondrial Src and hippocampal dendritic changes in Alzheimer's disease Coorientador de Laura Alexandrina Sequeira Neves	Mestrado Integrado em Engenharia Biomédica (Mestrado) Universidade de Coimbra Departamento de Física, Portugal
2015/09/01 - 2016/09/01	Amyloid-beta peptide-evoked Src signaling and redox changes in hippocampal cells Coorientador de Lígia Vanessa Fão	Ciências de Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/03/01 - 2016/06/17	Amyloid-beta peptide-evoked Src signaling in hippocampal cells Coorientador de Filipa Viegas	Bioquímica (Licenciatura/Bacharelato) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2016/03/21 - Atual	Collaboration in the organization of workshop Synaptosomes as a model of pre-synaptic dysfunction in brain pathologies -the role of mitochondria" organized within the XIX National meeting of Biology students. (2016/03/21) Oficina (workshop) (Membro da Comissão Organizadora)	CNC.IBILI, Portugal
2022/11/01 - 2023/12/02	Member of the local committee for the organization of the Meeting ¿Mitochondria in Aging, Cancer and Cell Death 2023¿ ; University of Coimbra, Coimbra, Portugal from 30 Nov to 2 Dec 2023. (2023/11/30 - 2023/12/02) Congresso (Membro da Comissão Organizadora)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2023/09/29 - Atual	Collaboration in the “European Researcher’s Night” at Coimbra University Exposição	European Researcher’s Night Universidade de Coimbra, Portugal
2022/09/30 - Atual	Collaboration in the “European Researcher’s Night” at Coimbra University Exposição	European Researcher’s Night Universidade de Coimbra, Portugal
2019/10 - 2019/11	Online interview by invitation for the “ASK Researchers” organized by the Science Communication Office of CNC Outro	ASK Reserachers Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/09/27 - 2019/09/27	Participation in the “European Researcher’s Night” at Coimbra University Exposição	European Researcher’s Night Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/09/02 - 2019/09/06	Responsible Tutor of Miriam Neves and Henrique Louro in the “Ciência Viva no laboratório 2019” initiative at CNC organized by the Ciência Viva Portuguese Organization Outro	Ciência Viva no laboratório Ciência Viva, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09/29 - 2017/09/29	Participation in the “European Researcher’s Night” at Coimbra University (September 29th, 2017) Exposição	European Researcher’s Night Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/03/13 - 2016/03/19	Tutor of “International Brain Awareness Week 2016” (Jardim de infância de Almas Freire, Coimbra) Outro	International Brain Awareness Week 2016 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/03/08 - 2014/03/15	Tutor of “International Brain Awareness Week 2014” (escola secundária EB2/3 Dr. Correia Mateus, Leiria) Outro	International Brain Awareness Week 2014 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/03/11 - 2013/03/17	Tutor of “International Brain Awareness Week 2013” (escola primária EB1 da Solum, Coimbra) Outro	International Brain Awareness Week 2013 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/03/14 - 2011/03/20	Tutor of “International Brain Awareness Week 2011” (escola primária de Lordemão, Coimbra) Outro	International Brain Awareness Week 2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/03/15 - 2010/03/21	Tutor of “International Brain Awareness Week 2010” (Jardim de infância a Casa da Avó, Coimbra) Outro	International Brain Awareness Week 2010 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/03/15 - 2009/03/22	Tutor of “International Brain Awareness Week 2009” (Escola EB1 do Passadouro, Troviscal and Externato João XXIII, Coimbra) Outro	International Brain Awareness Week 2009 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2019/09/12	Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease Arguente principal	Marta Sofia Rosendo Pereira (Mestrado) Universidade de Coimbra, Portugal

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2015/05/29 - Atual	Oxidative stress in Alzheimer's disease: an attempt to identify new markers (seminar)	Neurobiology II (Mestrado integrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/03/29 - Atual	Collaboration in the classroom practice	Fundamental Neurosciences (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2011/11/30 - Atual	Aß oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal cultures (seminar)	Neurobiology I (Mestrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/03/10 - 2023/03/10	Cell quality Control and Autophagy in Cancer	Master in Cellular and Molecular Biology	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2022/03/14 - 2022/03/18	Lecturer/ Practical classes	Master in Cellular and Molecular Biology (Mestrado)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2021/03/09 - 2021/03/09	Skeletal muscle autophagy alterations during aging	PHD Programme in Experimental Biology and Biomedicine (Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/03/03 - 2021/03/03	Practical course within the course Mechanisms of Neurodysfunction and Neurodegeneration of the Master in Molecular and translational Neurosciences from the Faculty of Medicine, University of Coimbra.	Master in Molecular and translational Neurosciences (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2019/09/04	Interview given in the context of the initiative "Ciência Viva no Laboratório- Ocupação Científica de Jovens nas Férias" (Life Science at the Laboratory- Scientific Occupation of Young People on Vacation).	Diário de Coimbra

Membro de associação

	Nome da associação	Tipo de participação
2012/09/13 - Atual	Portuguese Society of Neurosciences (SPN_ Sociedade Portuguesa de Neurociências)	Adherent Member
2016 - 2018	International Society of Neurochemistry	Membership

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2021/10 - 2021/11	Jury member for the award of a Junior PhD Investigator contract with the reference 29621.08.2021 under the Investigation project PTDC/BTM-TEC/29621 /2017 from FCT at Center for Neurosciences and Cell Biology of Coimbra	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/09 - 2021/09/30	Jury member for the award of a laboratory technician grant with the reference CTM 29621 under the Investigation project PTDC/BTM-TEC/29621 /2017 from FCT at Center for Neurosciences and Cell Biology of Coimbra	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/01 - 2021/02	Jury member for the award of a research grant with the reference IN0828 (Lugus 714624) under the project "Healthy Aging 2020 (CENTRO-01-0145-FEDER-000012)" at the group Mitochondria and Neurodegenerative Disorders at Center for Neuroscience of Coimbra.	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/10/21 - 2019/10/21	Jury member for the award of a research grant with the reference IN0828 (Lugus 623472) under the project "Healthy Aging 2020 (CENTRO-01-0145-FEDER-000012)" at the group Mitochondria and Neurodegenerative Disorders at Center for Neuroscience of Coimbra.	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Tutoria

	Tópico	Nome do aluno
2021/09/01 - Atual	Responsible for the technical and scientific supervision of PhD in Experimental Biology and Biomedicine - Oncology, Center for Neuroscience and Cell Biology, University of Coimbra. “Organelle-targeted Radioconjugates for Auger Therapy of Cancer: Biochemic	Margarida C M Sobral.
2021/09/01 - 2022/09/30	Responsible for the technical and scientific supervision of M. Sc. in Cellular and Molecular Biology, Faculty of Science and Technology, Center for Neuroscience and Cell Biology, University of Coimbra. “Organelle-targeted radioconjugates for Auger therapy	Rafael P Silveira
2019/09/15 - 2019/12/15	Co-advisor of Laboratory Rotation discipline in the context of M. Sc. In Biochemistry of the Faculty of Sciences and Technology, Center for Neuroscience and Cell Biology, University of Coimbra.	Lavínia Perquim
2018/09/22 - 2019/10/17	Collaboration in the technical and scientific supervision of M. Sc. In Neurobiology of University of Porto, Center for Neuroscience and Cell Biology	Daniela Marinho Lopes
2019/03/01 - 2019/06/30	Responsible for the technical and scientific supervision of M. Sc. In Biology of Erasmus student from Salermo University (Italy), Center for Neuroscience and Cell Biology, University of Coimbra	Mirela Giordano
2017/01/02 - 2017/02/24	Collaboration in the technical and scientific supervision of International Student from Exchange Program (“Projeto pesquisadores do Futuro”, Santa Casa da Misericórdia de São Paulo, Brasil)	Letícia Yuki Matsushita
2015/09/01 - 2016/09/16	Collaboration in technical supervision of M. Sc. in Cellular and Molecular Biology, Center for Neuroscience and Cell Biology, University of Coimbra. Early mitochondrial modifications in YAC128 transgenic model of Huntington’s disease.	Carina Sofia Barradas Maranga
2015/05/29 - 2015/05/29	Oxidative stress in Alzheimer's disease: an attempt to identify new markers	course “Neurobiology II” in Biomedical Enginery
2012/03/29 - 2012/03/29	classroom practice of Neurosciences	Course Neurosciences, Faculty of Medicine,
2011 - 2012	Collaboration in technical supervision of M. Sc. in Biology, Center for Neuroscience and Cell Biology, University of Coimbra. Changes in transcription factors related to mitochondrial biogenesis and antioxidant defense in alzheimer’s disease models	Gladys Tarcila Lima Caldeira
2011/11/30 - 2011/11/30	Aß oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal cultures	the course “Neurobiology I” in Biomedical Enginery
2010 - 2010	Collaboration in technical supervision of M. Sc. in Biology, Center for Neuroscience and Cell Biology, University of Benevento (Italy). Erasmus Programme	Carmen Padovano
2010 - 2010	Collaboration in technical supervision of M. Sc. in Biology, Center for Neuroscience and Cell Biology, University of Benevento._ Erasmus Programme	Chiara D’Amati
2009 - 2010	Collaboration in technical supervision of M. Sc. Degree in Medicine, Center for Neuroscience and Cell Biology, University of Coimbra	Luís Miguel Morais Calado de Oliveira Bajouco

Distinções

Outra distinção

2016	Participation grant to attend the 7th ISN 2016 Special Neurochemistry Confrence, Coimbra, Portugal; 1-4 June, 2016 Sociedade Portuguesa de Neurociências, Portugal