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C Pereira is Biochemist (1991), Master in Cell Biology (1994) and received, in 2000, her PhD in Cell Biology from the Faculty of Sciences and Technology, University of Coimbra (UC), Portugal. Presently, she is Investigator (with tenure) at the Faculty of Medicine, UC (FMUC), and is also Principal Investigator (PI) of the research line Endoplasmic Reticulum (ER) Stress Response and ER-Mitochondria Axis at the Cell Signaling and Metabolism group from the Center for Neuroscience and Cell Biology (CNC), which integrates the Center for Innovative Biomedicine and Biotechnology (cibb) at UC, recently renewed the Associated Laboratory status with a top 100% score. C Pereira has a long-lasting and fruitful collaboration with the Neurology and Psychiatry Departments from the Coimbra University Hospital (CHUC). The specific aims of her research line are to clarify the biological basis of neuropsychiatric diseases, namely neurodegenerative disorders such as Alzheimers disease and mood disorders such as bipolar disorder, focusing on the pathological deregulation of cellular and organelle stress responses, and its implications in metabolism and innate immunity, as well as to explore the therapeutic potential of Portuguese natural resources (collaboration with Portuguese Spring Waters and Forest Industry). For these purposes, both in vitro (cell lines and primary cell cultures) and in vivo experimental models (transgenic mice) and also human biological samples (blood samples and skin-derived fibroblasts) are used. She participated in several funded projects, either as PI/co-PI or as team member. C Pereira published almost 80 peer-reviewed papers, the majority in international quartile 1 (Q1) journals. Some publications are co-authored by her collaborators in USA and EU. The scientific impact of her research is reflected in the H index (37) and high number of citations (~ 4000) (Web of Science). In 2004 C Pereira was awarded with the LOréal For Women in Science Prize (1st edition). Since then, she is member of the Evaluation Board of this L'Oréal Portugal/UNESCO/FCT award. She supervised several PhD (7 concluded, 3 ongoing) and Master (>20 concluded) thesis, research fellows, UC 1st cycle studies and ERASMUS students. She is actively enrolled in Master and PhD programs at UC as lecturer or member of organizing committee, thesis supervision, thesis evaluation board (Evaluator, President or Vogal). In addition, she teaches (1st cycle) since 2008: integrated masters in Medicine and Biomedical Engineering (UC), and also at Coimbra Health School (ESTESC). She is Editor of scientific journals such as International Journal of Molecular Sciences, and Frontiers in Neurosciences. She revised papers submitted for publication to J Neurosci, Cell Death Diff, Free Radic Biol Med, Neurobiol Aging, Neurobiol Dis, among many other journals. C Pereira has integrated the evaluation board of funding agencies such as ARS (France), DFG (Germany), AA (USA) and also FCT (Portugal). She was invited speaker and/or co-authored more than 50 oral and 100 poster communications in (inter)national scientific meetings. She actively participated in several science outreach projects and activities (organization commitee or collaborator), namely "Ciencia Viva during Summer Holidays", "Brain Awareness Week", among many others, and she was invited to participate in events in media and broad end-users (TV, radio, newspapers, social networks, institutional webpage). She was invited to participate in the 2021 edition of “Mulheres na Ciência" book that brings together portraits of researchers. In addition to her research and teaching duties, C Pereira is also enrolled in FMUC management as member of the Faculty Assembly and as Advisor of the Research Vice-Diretor, and is presently member of the Board of Directors of CNC. C Pereira is volunteer at the "Machado de Castro" Museum (Coimbra, Portugal) in the project "EU no MusEU" (collaboration with the Alzheimer Portugal Association).
Identificação

Identificação pessoal

Nome completo
Cláudia Maria Fragão Pereira

Nomes de citação

  • Pereira, Cláudia
  • Pereira, Cláudia Fragão
  • Pereira, Cláudia Maria Pereira

Identificadores de autor

Ciência ID
6A1D-22C8-B2A3
ORCID iD
0000-0002-6630-5056

Endereços de correio eletrónico

  • cpereira@fmed.uc.pt (Profissional)
  • cpereira@cnc.uc.pt (Profissional)

Telefones

Fax
  • 239822776 (Profissional)
Telefone
  • 239820190 (Profissional)

Moradas

  • Faculdade de Medicina, Pólo III, Universidade de Coimbra. Faculdade de Medicina, pólo Ciências da Saúde, Univ. Coimbra, Azinhaga de Santa Comba, Celas, 3000-354, Coimbra, Coimbra, Portugal (Profissional)
  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Rua Larga, Faculdade de Medicina, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • ---http://www.cnbc.pt/research/department_group_show.asp?iddep=1138&idgrp=1142 (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
1995 - 2000/12/15
Concluído
Doutoramento em Biologia (Doutoramento)
Especialização em Biologia Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mecanismos de degenerescência celular em dois modelos de stress oxidativo induzido por glutamato e pela proteína beta-amilóide. Implicações para a etiopatogenia da doença de Alzheimer" (TESE/DISSERTAÇÃO)
Aprovada por unanimidade, com distinção e louvor (
1992 - 1994
Concluído
Mestrado em Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Efeito da peroxidação lipídica na actividade respiratória mitocondrial e nos mecanismos de regulação do cálcio em sinaptossomas" (TESE/DISSERTAÇÃO)
Muito bom
1987/09 - 1991/07
Concluído
Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n.a." (TESE/DISSERTAÇÃO)
Bom:15 (20) valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2000/12/16 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2000 - Atual Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/12/30 - 2000/12/15 Assistente de Investigação (carreira) (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2008 - Atual Professor Coordenador Convidado (Docente Ensino Superior Politécnico) Universidade de Coimbra Faculdade de Medicina, Portugal
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2019 - Atual Assessora do Sub-Diretor para a Investigação Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/10 - 2022/09 Membro da Direção Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projetos

Bolsa

Designação Financiadores
1995 - 1998 Mecanismos de degenerescência celular em dois modelos de stress oxidativo induzido por glutamato e pela proteína beta-amilóide. Implicações para a etiopatogenia da doença de Alzheimer
BD/3889/94
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
1992 - 1993 Efeito da peroxidação lipídica na actividade respiratória mitocondrial e nos mecanismos de regulação do cálcio em sinaptossomas
BM/1444/91-ID
Bolseiro de Mestrado
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2019 - Atual Impact of the action of natural products on human innate immune and tumor cells
88887.194785/2018-00
Investigador
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brasil
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
2020 - 2026/12 MIA-Portugal
857524
Investigador
Universidade de Coimbra, Portugal
Horizon 2020
2019 - 2021 Saude no Saber
45-2019/478
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ciência Viva
2018 - 2021 Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease
CENTRO-01-0145-FEDER-029369
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021 InPaCTus
COMPETE 21874
COMPETE2020 nº 21874
Investigador responsável
Universidade de Coimbra, Portugal
Agência Nacional de Inovação SA
2018 - 2021 The ups and downs of cellular stress. the "MAM" hypothesis for Bipolar disorder pathophysiology
CENTRO-01-0145-FEDER-028214
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019/06/30 Drugs2CAD
CENTRO-01-0247- FEDER-003269
Investigador
Universidade de Coimbra, Portugal
European Regional Development Fund
2017 - 2018 Valorization of the thermal resorts of the Centre Region- characterization of the bioactive potential of the thermal water resources of the region: study of the therapeutic potential of thermal waters- dermocosmetic
CENTRO-04-3928-FEDER-000010
Investigador
Universidade de Coimbra, Portugal
Horizon 2020 Framework Programme
2017 - 2018 New BACE1 inhibitors for the treatment of Alzheimer's disease: an approach for the development of effective and safe substrate-selective inhibitors
EDGAR CRUZ SILVA 2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Edgar Cruz e Silva
2014 - 2015 Diagnóstico y combate molecular de tres enfermedades neurodegenerativas (Parkinson, fenilcetonuria y amiloidosis TTR)
NEUROMED
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Commission Seventh Framework Programme for Research and Technological Development
2013 - 2015 Tackling Alzheimer’s disease with a new peptide inhibitor of BACE1
PTDC/NEU-SCC/1351/2012
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
2012 - 2013 Influence of cell age and CX3CL1/CX3CR1 signaling on microglial-neuronal dialogue in Alzheimer’s disease pathogenesis
EDGAR CRUZ SILVA 2012
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação Edgar Cruz e Silva
2011 - 2012 Amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine
01CP11
Investigador responsável
Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina
2011 - 2012 Crosstalk between endoplasmic reticulum and mitochondria in diabetes-related neurodegeneration: bringing bedside problems to the bench
02CP11
Investigador responsável
Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina
2010 - 2012 Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation
PTDC/QUI-QUI/102049/2008
Investigador
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2012 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
PTDC/SAU-NEU/103538/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2012 The pathological interaction between diabetes and Alzheimer’s disease: exploring the role of brain endothelial mitochondria and uncoupling proteins
PTDC/SAU-NEU/103325/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2008 - 2010 Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer’s disease
PTDC/SAU-NEU/71675/2006
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2008 - 2010 Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
PIC/IC/83206/2007
Investigador
Hospitais da Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2008 - 2010 Towards novel inhibitors of Alzheimer's disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs
III/40/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar
2007 - 2007 Let’s study the brain: neuroscientists at school and schools at neuroscience laboratories
BAW2007
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - 2007 Signaling pathways involved in the cross-talk between alpha-synuclein and beta-amyloid proteins in Alzheimer’s disease neurodegeneration
III_CP2005
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar
1999 - 2003 A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies
POCTI/1999/NSE/36101
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Outro

Designação Financiadores
2014 - Atual Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
info:eu-repo/grantAgreement/FCT/3599-PPCDTI/135805/PT
Universidade do Algarve Faculdade de Ciências e Tecnologia
2017 - 2020/12/31 HealthyAging2020
CENTRO-01-0145-FEDER-000012
Investigador
Universidade de Coimbra, Portugal
EU Framework Programme for Research and Innovation Excellent Science
2013 - 2014 Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role?
GAI 2014
Investigador
Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina
2013 - 2014 How does autophagy modulate inflammasome activation?
GAI 2014_2
Investigador responsável
Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina
2007 - 2013 New strategies to manage brain diseases
CENTRO-07-ST24-FEDER-002002
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
EU Framework Programme for Research and Innovation Excellent Science
2007 - 2013 Aging, stress and chronic diseases: from mechanisms to therapeutics
CENTRO-07-ST24-FEDER-002006
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
EU Framework Programme for Research and Innovation Excellent Science
2009 - 2011 Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine
LUNDBECK2009
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Lundbeck Portugal
2004 - 2005 Cross-talk” between mitochondria and endoplasmic reticulum in Alzheimer’s disease. Studies with cybrids
FOE WOMEN IN SCIENCE 2004
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease". Biomedicines 9 8 (2021): 881-881. https://doi.org/10.3390/biomedicines9080881.
    10.3390/biomedicines9080881
  2. Ana P. Marques; Rosa Resende; Diana F. Silva; Mariana Batista; Daniela Pereira; Brigite Wildenberg; Sofia Morais; et al. "Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients". Biomedicines (2021): https://www.mdpi.com/2227-9059/9/5/522.
    10.3390/biomedicines9050522
  3. Pereira, Cláudia. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy 8 (2021): 1-382.
    Publicado
  4. Pereira, Ana Catarina; Oliveira, Joana; Silva, Sónia; Madeira, Nuno; Pereira, Cláudia M.F.; Cruz, Maria T.. "Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets". Pharmacological Research 163 (2021): 105325. http://dx.doi.org/10.1016/j.phrs.2020.105325.
    Publicado • 10.1016/j.phrs.2020.105325
  5. Domingues, Raquel; Pereira, Claúdia; Cruz, Maria Teresa; Silva, Ana. "Therapies for Alzheimer’s disease: a metabolic perspective". Molecular Genetics and Metabolism S1096-71 21 (2021): http://dx.doi.org/10.1016/j.ymgme.2021.01.011.
    Publicado • 10.1016/j.ymgme.2021.01.011
  6. Silva, A.; Oliveira, A. S.; Vaz, C. V.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al. "Anti-inflammatory potential of Portuguese thermal waters". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-79394-9.
    Publicado • 10.1038/s41598-020-79394-9
  7. Ana Sofia Oliveira; Cátia Vicente Vaz; Ana Silva; Sara Correia; Raquel Ferreira; Luiza Breitenfeld; José Martinez-de-Oliveira; et al. "In vitro evaluation of potential benefits of a silica-rich thermal water (Monfortinho Thermal Water) in hyperkeratotic skin conditions". International Journal of Biometeorology (2020): https://doi.org/10.1007/s00484-020-01986-x.
    10.1007/s00484-020-01986-x
  8. Cardoso, Remy; Lemos, Carolina; Oliveiros, Bárbara; Almeida, Maria Rosário; Baldeiras, Inês; Pereira, Cláudia Fragão; Santos, Ana; et al. "APOE ¿4-TOMM40L Haplotype Increases the Risk of Mild Cognitive Impairment Conversion to Alzheimer’s Disease". Journal of Alzheimer's Disease 78 2 (2020): 587-601. http://dx.doi.org/10.3233/jad-200556.
    Publicado • 10.3233/jad-200556
  9. Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; et al. "Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models". International Journal of Molecular Sciences 21 20 (2020): 7791. http://dx.doi.org/10.3390/ijms21207791.
    10.3390/ijms21207791
  10. Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al. "New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models". Journal of Alzheimer's Disease 70 6 (2020): 1317-1337. http://dx.doi.org/10.3233/jad-200381.
    Publicado • 10.3233/jad-200381
  11. R. Resende; T. Fernandes; A.C. Pereira; J. De Pascale; A.P. Marques; P. Oliveira; S. Morais; et al. "Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 6 (2020): 165752-165752. https://doi.org/10.1016/j.bbadis.2020.165752.
    Publicado • 10.1016/j.bbadis.2020.165752
  12. Cátia S. D. Oliveira; Patrícia Moreira; Judite Resende; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre. "Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata". International Journal of Molecular Sciences 21 5 (2020): 1814-1830. https://doi.org/10.3390/ijms21051814.
    Acesso aberto • 10.3390/ijms21051814
  13. Luísa Cortes; João Malva; Ana Cristina Rego; Cláudia F. Pereira. "Calcium Signaling in Aging and Neurodegenerative Diseases 2019". International Journal of Molecular Sciences 21 3 (2020): 1125-1125. https://doi.org/10.3390/ijms21031125.
    10.3390/ijms21031125
  14. Jan Parys; C Pereira; Carlos Villalobos. "The Eighth ECS Workshop on “Calcium Signaling in Aging and Neurodegenerative Diseases”". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/24/6263.
    10.3390/ijms20246263
  15. Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa. "Is Alzheimer’s disease an inflammasomopathy?". Ageing Research Reviews 56 (2019): 100966. http://dx.doi.org/10.1016/j.arr.2019.100966.
    10.1016/j.arr.2019.100966
  16. Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Ferreira, Sandra Saraiva; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; et al. "Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens". Environmental Geochemistry and Health (2019): http://dx.doi.org/10.1007/s10653-019-00473-6.
    Publicado • 10.1007/s10653-019-00473-6
  17. Placido, Ana I.; Pereira, Claudia M. F.; Correira, Sonia C.; Carvalho, Cristina; Oliveira, Catarina R.; Moreira, Paula I.. "Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells". Molecular Neurobiology 54 1 (2017): 154-168. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392133900014&KeyUID=WOS:000392133900014.
    10.1007/s12035-015-9640-1
  18. Oliveira, C. R.; Pereira, C.; Rego, A. C.; Moreira, P. I.; Cardoso, S.. "When, where and how: mitochondrial multifaceted dysfunction in Alzheimer's disease". European Journal of Clinical Investigation 47 (2017): 24-25. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412099900035&KeyUID=WOS:000412099900035.
  19. Placido, Ana I.; Pereira, Claudia M. F.; Duarte, Ana I.; Candeias, Emanuel; Correia, Sonia C.; Carvalho, Cristina; Cardoso, Susana; Oliveira, Catarina R.; Moreira, Paula I.. "Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?". Cns & Neurological Disorders-Drug Targets 14 4 (2015): 518-533. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354179100012&KeyUID=WOS:000354179100012.
    10.2174/1871527314666150429112353
  20. Mota, Sandra I.; Costa, Rui O.; Ferreira, Ildete L.; Santana, Isabel; Caldeira, Gladys L.; Padovano, Carmela; Fonseca, Ana C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica Et Biophysica Acta-Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355715200021&KeyUID=WOS:000355715200021.
    10.1016/j.bbadis.2015.03.015
  21. Ferreira, Ildete Luisa; Ferreiro, Elisabete; Schmidt, Jeannette; Cardoso, Joao M.; Pereira, Claudia M. F.; Carvalho, Ana Luisa; Oliveira, Catarina R.; Cristina Rego, A.. "A beta and NMDAR activation cause mitochondrial dysfunction involving ER calcium release". Neurobiology of Aging 36 2 (2015): 680-692. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352454400014&KeyUID=WOS:000352454400014.
    10.1016/j.neurobiolaging.2014.09.006
  22. Correia, Sonia C.; Resende, Rosa; Moreira, Paula I.; Pereira, Claudia M.. "Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu". DNA and Cell Biology 34 4 (2015): 261-273. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352342300005&KeyUID=WOS:000352342300005.
    10.1089/dna.2014.2757
  23. Fonseca, Ana Catarina R. G.; Moreira, Paula I.; Oliveira, Catarina R.; Cardoso, Sandra M.; Pinton, Paolo; Pereira, Claudia F.. "Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells". Molecular Neurobiology 51 2 (2015): 610-622. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800015&KeyUID=WOS:000351311800015.
    10.1007/s12035-014-8740-7
  24. Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T.. "Bioactivity and safety profile of Daucus carota subsp maximus essential oil". Industrial Crops and Products 77 (2015): 218-224. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000366065200028&KeyUID=WOS:000366065200028.
    10.1016/j.indcrop.2015.08.037
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  80. Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R.; Pereira, C; Ferreiro, E; Cardoso, SM; de Oliveira, CR. "Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease". Journal of Molecular Neuroscience 23 1-2 (2004): 97-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS.
    10.1385/JMN:23:1-2:097
  81. Pereira, Claudia; Agostinho, Paula; Moreira, Paula I; Duarte, Ana I; Santos, Maria S; Oliveira, Catarina R. "[Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models].". Acta medica portuguesa 16 6 (2003): 401-6. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:15631851&KeyUID=MEDLINE:15631851.
  82. Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS.
  83. Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina. "Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide". Antioxidants & Redox Signaling 2 2 (2000): 317-325. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014.
    10.1089/ars.2000.2.2-317
  84. Pereira, CF; de Oliveira, CR. "Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis". Neuroscience Research 37 3 (2000): 227-236. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000088427400008&KeyUID=WOS:000088427400008.
    10.1016/S0168-0102(00)00124-3
  85. Pereira, C; Agostinho, P; Oliveira, CR; Pereira, C.; Agostinho, P.; Oliveira, C.R.. "Vinpocetine attenuates the metabolic dysfunction induced by amyloid beta-peptides in PC12 cells". Free Radical Research 33 5 (2000): 497-506. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166441800006&KeyUID=WOS:000166441800006.
    10.1080/10715760000301041
  86. Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R.. "Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress". Experimental Neurology 161 1 (2000): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS.
    10.1006/exnr.1999.7270
  87. Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C.. "Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide". Antioxidants and Redox Signaling 2 2 (2000): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS.
  88. Cardoso, S.M.; Pereira, C.; Oliveira, C.R.. "Mitochondrial function is differentially affected upon oxidative stress". Free Radical Biology and Medicine 26 1-2 (1999): 3-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS.
    10.1016/S0891-5849(98)00205-6
  89. Pereira, C.; Santos, M.S.; Oliveira, C.. "Involvement of oxidative stress on the impairment of energy metabolism induced by Aß peptides on PC12 cells: Protection by antioxidants". Neurobiology of Disease 6 3 (1999): 209-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033022771&partnerID=MN8TOARS.
    10.1006/nbdi.1999.0241
  90. Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C.. "Metabolic inhibition increases glutamate susceptibility on a PC12 cell line". Journal of Neuroscience Research 51 3 (1998): 360-370. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000071805700009&KeyUID=WOS:000071805700009.
    10.1002/(SICI)1097-4547(19980201)51:3<360::AID-JNR9>3.3.CO;2-7
  91. Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C.. "Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells". Neuroreport 9 8 (1998): 1749-1755. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074198700015&KeyUID=WOS:000074198700015.
    10.1097/00001756-199806010-00015
  92. Cardoso, S.M.; Pereira, C.; Oliveira, C.R.. "The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes". Biochemical and Biophysical Research Communications 246 3 (1998): 703-710. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS.
    10.1006/bbrc.1998.8563
  93. Pereira, C.M.F.; Oliveira, C.R.. "Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress". Free Radical Biology and Medicine 23 4 (1997): 637-647. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030757990&partnerID=MN8TOARS.
    10.1016/S0891-5849(97)00020-8
  94. Pereira, C.; Ferreira, C.; Carvalho, C.; Oliveira, C.. "Contribution of plasma membrane and endoplasmic reticulum Ca2+-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress". Brain Research 713 1-2 (1996): 269-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029928472&partnerID=MN8TOARS.
    10.1016/0006-8993(95)01554-X
  95. Pereira, Cláudia; Resende de Oliveira, Catarina. "Effect of lipid peroxidation on [Ca2+]i of rat synaptosomes". Journal of Neurochemistry supplement (1993): S151D-S151D.
    Publicado
Capítulo de livro
  1. Pereira, Cláudia; Catarina Resende de Oliveira. "Envelhecimento cerebral e doença de Alzheimer". In Neurociências, editado por Rego, Ana Cristina; Bandeira-Duarte, Carlos; Catarina Resende de Oliveira, 1-740. Portugal: LIDEL, 2017.
    Publicado
  2. Pereira, Cláudia; Resende, Rosa; Resende de Oliveira, Catarina; Resende, R.; Oliveira, C.R.; Pereira, C.M.F.. "Role of glycogen synthase kinase-3beta on tau phosphorylation in Alzheimer’s disease". In Advances in Medicine and Biology, editado por Leon V. Berhardt, 197-210. Nova Science Publishers, 2010.
    Publicado
  3. Pereira, Cláudia. "Epigenetics and neurodegeneration: a connection overlooked.". In Epigenetics: Mechanisms, Functions and Human Effects, editado por Balázs Pintér; Zsolt Mészáros. Nova Science Publishers, 2010.
  4. Pereira, Cláudia; Grazina, Manuela; Catarina Resende de Oliveira. "ß-Amyloid protein impairs mitochondrial function". In Mitochondrial ubiquinone (coenzyme Q10): biochemical, functional, medical and therapeutic aspects in human health and diseases, editado por Manuchair S Ebadi, 282-300. Prominent Press, 2001.
Edição de número de revista
  1. Pereira, Cláudia; Parys, Jan; Villalobos, Carlos. "Calcium Signaling in Aging and Neurodegenerative Diseases". International Journal of Molecular Sciences (2020): https://gbiomed.kuleuven.be/english/research/50000618/50753344.
    No prelo
  2. Pereira, Cláudia; Neves, Bruno Miguel; Krüger, Elka. "The Role of ER Stress and the UPR in Shaping Immunity". Frontiers in Immunology (2020): https://www.frontiersin.org/research-topics/9234/the-role-of-er-stress-and-the-upr-in-shaping-immunity#articles.
    Em revisão
Tese / Dissertação
  1. Pereira, Cláudia. "Mecanismos de degenerescência celular em dois modelos de stress oxidativo induzido por glutamato e pela proteína beta-amilóide. Implicações para a etiopatogenia da doença de Alzheimer". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2000. http://hdl.handle.net/10316/10178.
  2. Pereira, Cláudia. "Efeito da peroxidação lipídica na actividade respiratória mitocondrial e nos mecanismos de regulação do cálcio em sinaptossomas". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1994. porbase.bnportugal.pt/ipac20/ipac.jsp?session=12508572JO65S.211562&profile=porbase&uri=link=3100018~!165619~!3100024~!3100022&aspect=basic_search&menu=search&ri=1&source=~!bnp&term=Pereira%2C+Cláudia+Maria+Fragão&index=AUTHOR.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/03 Beneficial effects of compounds extracted from Eucalyptus globulus biomass on skin health XXV TECNICELPA - International Forest, Pulp and Paper Conference, XI CIADICYP
Tecnicelpa (webconference, Portugal)
2021/03 MITOCHONDRIAL (DYS)FUNCTION AND DYNAMICS IN FIBROBLASTS OF EARLY BIPOLAR DISORDER PATIENTS 20th WPA World Congress of Psychiatry
World Psychiatry Association (virtual congress)
2021/02 EFFECT OF ENDOPLASMIC RETICULUM (ER) STRESS ON ER-MITOCHONDRIA CONTACTS IN THE INNATE IMMUNE SYSTEM SPF Meeting 2021
Faculdade de Farmácia da Universidade de Lisboa (webconference, Portugal)
2020/09 Structural and functional alterations in endoplasmic reticulum-mitochondria contacts in Alzheimer's disease in vitro models 34 ª Reunião do GEECD
Grupo de Estudos de Envelhecimento Cerebral e Demências (GEECD) (webconference, Portugal)
2020/02 Changes in the Protein Composition of Mitochondrial-Associated Membranes (MAMs) in Alzheimer’s disease SPF Meeting 2020
Universidade de Coimbra Faculdade de Farmácia (Coimbra, Portugal)
2019/11/15 ER stress-induced sterile inflammation in Bipolar disorder (Award "Best Oral Communication") 1st Annual Meeting in Pharmaceutical Sciences
Faculty of Pharmacy (Coimbra, Portugal)
2019/05 The cellular stress response in the innate immune system 53rd ESCI2019 Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Coimbra, Portugal)
2019/03/15 Impairment of the cellular stress response in neuropsychiatric disorders. Seminar
Institute of Biology and Molecular Genetics (IBGM) (Valladolid, Espanha)
2019/03 Endoplasmic Reticulum Stress: new insights in metabolic disorders. 15th International Symposium of the Portuguese Society of Metabolic Disorders
Portuguese Society of Metabolic Disorders (Coimbra, Portugal)
2017/09 Primary neuronal cultures as a cellular model to study ageing and age-related disorders Course "Fundamentals of Animal Cell Culture"
University of Aveiro, Portugal (Aveiro, Portugal)
2016/12 ER and mitochondria in Alzheimer’s disease: Best Friends Forever? 1st Meeting on Biomedical Research@UC
University of Coimbra, Portugal (Coimbra, Portugal)
2015/11 Neurobiologia da doença Bipolar: rumo a novas estratégias terapêuticas e biomarcadores / Neurobiology of Bipolar disorder: towards novel therapeutic strategies and biomarkers XI National Congress of Psychiatry
Sociedade Portuguesa de Psiquiatria e Saúde Mental/Portuguese Society of Psychiatry and Mental Health (Vilamoura, Portugal)
2015/06/13 Memória e plasticidade neuronal / Memory and neuronal plasticity X Jornadas de Audiologia
Escola Superior de Tecnologias da Saúde de Coimbra (Coimbra, Portugal)
2014/03/29 Mecanismos moleculares subjacentes a` disfunção cerebrovascular na doença de Alzheimer / Molecular mechanisms underlying cerebrovascular dysfunction in Alzheimer's disease 2nd Annual Meeting Coimbra Health School
Escola Superior de Tecnologias da Saúde de Coimbra (Coimbra, Portugal)
2014 Impairment of stress response during ageing Coimbra & Newcastle Universities joint Summer school - Understanding the complexity of Ageing
University of Coimbra, Portugal (Coimbra, Portugal)
2011/09 - Towards novel inhibitors of Alzheimer’s disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs First III-UC Researcher Forum
Interdisciplinary Research Institute (III), University of Coimbra (Coimbra, Portugal)
2011/09 Cross-talk between alpha-synuclein and beta-amyloid proteins in Alzheimer’s disease First III-UC Researcher Forum
Interdisciplinary Research Institute (III), University of Coimbra (Coimbra, Portugal)
2011/04/15 Mitochondrial dysfunction in Alzheimer’s disease: lessons from cellular models
Cooperativa de Ensino Superior e Politécnico Universitário (CESPU) (Gandra, Portugal)
2008/11 Disease-modification strategies for Alzheimer’s Disease 1st National Meeting of Therapeutic Chemistry
University of Porto, Portugal (Porto, Portugal)
2008/05 Neurodegenerescência na doença de Alzheimer: lições obtidas com modelos celulares e animais Neurodegeneration in Alzheimer's disease: lessons from cellular and animal models VI National Biochemistry Meeting
Beira Interior University (Covilhã, Portugal)
2006/06/02 Fisiopatologia da doença de Alzheimer Physiopathology of Alzheimer's disease Workshop on neurodegenerative diseases
Moderna University (Lisbon, Portugal)
2006/02/10 Fisiopatologia da doença de Alzheimer e outras demências Physiopathology of Alzheimer's disease and other dementias Theoretical-pratical course about dementia
Hospitais da Universidade de Coimbra (Coimbra, Portugal)
2004/12 Neurodegeneration in Alzheimer’s disease induced by beta-amyloid peptides XIV Congress of Biochemistry
Portuguese Society for Biochemistry (SPB) (Vilamoura, Portugal)
2002/09 Cell degeneration induced by amyloid-beta peptides. Implications for Alzheimer’s disease Novel Therapeutic Opportunities in Neurodegenerative Disease
University of Aveiro, Portugal (Aveiro, Portugal)
1999/09 Oxidative stress hypothesis for the pathogenesis of Alzheimer’s disease IV Congress of Free Radicals in Chemistry, Biology and Medicine
(Troia, Portugal)
1998/11 ß-amyloid-associated oxidative stress and cytotoxicity: implications for Alzheimer’s disease XI National Congress of Biochemistry
Portuguese Society for Biochemistry (SPB) (Tomar, Portugal)
1997/12 ß-Amyloid toxicity in neurodegeneration IV Meeting of the Portuguese Society for Neurosciences
Portuguese Society for Neurosciences (SPN) (Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2020/01 - Atual Circadian rhythm disruption in Bipolar disorder: from molecular mechanisms to novel therapeutic targets PhD fellowship from FCT: SFRH/BD/148653/2019
Orientador
Doutoral Program in Health Sciences (Biomedical Sciences) (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/01 - Atual Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism. PhD fellowship from FCT: SFRH/BD/148801/2019
Coorientador
Doutoral Program in Health Sciences (Biomedical Sciences) (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - Atual Characterization of phytochemical components of Eucalyptus globulus leaves and their pharmacological potentials: a multi-functional insight DOUTORAMENTO EM EMPRESAS, # DBE UC-NAVIGATOR-06
Orientador
Doctoral Program in Pharmaceutical Sciences (Pharmacology and Pharmacotherapy) (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2021/02/22 Characterisation of glycoproteins involved in sea urchin adhesion
Orientador
Mestrado em Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2021/01/29 The Impact of Protein Tyrosine Phosphatases on the activation of Intraepithelial Lymphocytes.
Orientador
Mestrado em Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2020/12 Lipidomic alterations in the Mitochondria-Associated Membranes (MAMs) in Alzheimer's disease: analysis of biosynthetic enzymes in APPswe-overexpressing cells
Coorientador
Corso di Laurea Magistrale in Biotecnologie genetiche e molecolari (Mestrado)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Itália
2017 - 2019/09 O papel do neuropeptídeo Y nas funções dos condrócitos articulares / The role of neuropeptide Y in articular chondrocyte functions
Orientador de Caren Jane Rodrigues
Mestrado em Investigação Biomédica /Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2019/09 Histological and morphological analysis of developing neuronal precursors derived from human iPS cells
Orientador de Daniela Catarina Gaspar Santos
Mestrado em Investigação Biomédica / Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2019/09 Alergénios cutâneos: Moléculas com uma aplicação terapêutica improvável para a doença de Alzheimer / Skin allergens: Molecules with an improbable therapeutic application for Alzheimer's disease
Orientador de Marta Sofia Rosendo Pereira
Mestrado em Investigação Biomédica / Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2019 Mitochondria-associated membranes: a platform for transferring endoplasmic reticulum stress signals to mitochondria in innate immune cells. does lithium promote an adaptive cellular response and survival?
Orientador
Master in Cellular and Molecular Biology (Neurobiology) (Mestrado)
2016 - 2018 Deregulated inflammasome in Bipolar Disorder (BD): a matter of stress?
Orientador
Master in Cellular and Molecular Biology (Neurobiology) (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2018 Validation of a siRNA targeting PI3KCA gene towards colorectal cancer therapy
Orientador
Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2017 Role of miRNAs on cellular survival
Orientador
Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2017 Unravelling the circuits involved in ejaculation in mice (Mus musculus)
Orientador
Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012 - 2016/02 Role of endoplasmic reticulum stress on Alzheimer's disease-associated neuronal and endothelial dysfunction
Orientador
Doutoramento em Ciências da Saúde (Ramo Ciências Biomédicas) (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014 - 2016 Modulation of mitochondrial dynamics by the Influenza A virus
Orientador
Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2016 Endothelial cell response to deregulated proteostasis: analysis of ghrelin's protective action
Orientador
Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2015 Role of reactive oxygen species in inflammasome activation in microglia under stress conditions
Orientador
Master in Medicine (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2015 Endocytic trafficking mechanisms in Alzheimer’s disease: role of the actin regulators Bin1 and CD2AP
Orientador
Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2014 Loss of proteostasis in brain endotelial cells in an in vitro model of Alzheimer’s disease
Orientador
PhD program in Biochemistry (Cellular and Molecular Biology) (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2013 NMDA receptors-associated events and oxidative stress in models of Alzheimer’s disease
Coorientador
PhD program in Biology (Cellular Biology) (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2012 Chromatin remodeling in Alzheimer’s disease pathogenesis
Orientador
PhD program in Biology (Cellular Biology) (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007 - 2011 Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors
Orientador
PhD program Biology (Cellular Biology) (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2010 Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease
Orientador
Master in Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2010 Role of endothelial cells on survival of mature neurons. Implications for the etiopathogenesis of Alzheimer’s disease
Orientador
Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2010 Toxicity of amyloid-beta peptide in hypothalamic cells and protection by leptin and ghrelin. Implications for the etiopathogenesis of Alzheimer's disease
Orientador
Master in Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2010 From cerebrovascular alterations to therapeutical options in Alzheimer's disease
Orientador
Master in Medicine (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2005 - 2009 Neuroprotective effects of statins in an in vitro model of Alzheimer’s disease
Orientador
Master in Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2008 Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer’s and Prion’s diseases
Orientador
PhD program in Biology (Cellular BiologyY (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2008 Neurotoxicity induced by amyloid-beta peptide. The role of different assembies
Coorientador
PhD programa in Health Sciences (Biomedical Sciences) (Doutoramento)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2011 - Atual Science Communication “Ocupação Científica nas Férias de Verão” intership for secundary school students during summer holidays (1-2 weeks) “Ups and downs of Bipolar disorder”, September 2019 “Are our cells stressed?”, September 2018 “When Science gets water...”- stying the therapeutical propoerties of thermal mineral waters at center region of Portugal, July 2017 “Why does our memory fails when we age?” July 2011 (2011)
Outro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019 8th edition of the European Calcium Society (ECS) workshop, “Calcium Signaling in Aging and Neurodegenerative Disorders 2019”, University of Coimbra, Portugal (2019/09/18 - 2019/09/20)
Oficina (workshop) (Presidente da Comissão Organizadora)
Universidade de Coimbra, Portugal
2019 - 2019 "Neuroinflammation in Alzheimer’s disease", seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 11 April 2019 Speaker: Michael Heneka, German Center for Neurodegenerative Disorder (DZNE), Bonn, Germany; Department of Neurodegeneration Diseases and Geriatric Psychiatry, University Hospital of Bonn, Bona, Germany (2019/04/11 - 2019/11/11)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018 1st Meeting on Vesicular Biology (MVB) (http://cost-proteostasis.eu) (2018/02/16 - 2018/02/17)
Encontro (Membro da Comissão Científica)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2018 "Imaging of neuroinflammation and oxidative stress in psychotic disorder" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 21 December 2018 Speaker: Tiago Reis Marques, Mandsley Hospital; Institute of Psychiatry, King's College; Imperial College, London, United Kingdom (UK) (2018/12/21 - 2018/12/21)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018 "ER-mitochondria cross-talk in neurodegeneration: focus on Familial Alzheimer's disease" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 27 April 2018. Speaker: Paola Pizzo, Department of Biomedical Sciences, University of Padova, Padova, Italy (2018/04/27 - 2018/04/27)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018 "Tau therapeutics in brain pathology: Exploring the link between depression and Alzheimer’s disease" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 23 February 2018. Speaker: Ioannis Sotiropoulos, Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Portugal (2018/02/23 - 2018/02/23)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2015 "Endoplasmic reticulum stress in the Drosophila eye" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 08 May 2015. Speaker: Pedro Domingos, Laboratory Cell Signalling in Drosophila, ITQB, Oeiras, Portugal (2015/05/08 - 2015/05/08)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2013 XIII Reunião da Sociedade Portuguesa de Neurociências / XIII Meeting of the Portuguese Society for Neuroscience (2013/05/30 - 2013/06/01)
Encontro (Membro da Comissão Organizadora)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2010 2nd National Meeting on Medical Chemistry (2010/11/28 - 2010/11/30)
Encontro (Membro da Comissão Científica)
Universidade de Coimbra, Portugal
2004 - 2009 Science Communication "Brain Awareness Week", "Ciencia Viva nas Ferias de Verão", "Science Week", Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal (laboratorial and other activities for students and general audiences) (2004 - 2009)
Outro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008 - 2008 "Why Alzheimer is a disease of memory: the attack on synapses by Abeta oligomers" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 16 June 2008. Speaker: William L. Klein, Cognitive Neurology and Alzheimer's Disease Center, Nanoscale Science and Engineering Center, Northwestern University, Evanston, IL, USA (2008/06/16 - 2008/06/16)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - 2005 "Synucleins in Parkinson's disease: novel insights" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 24 June 2005. Speaker: Cristine Alves da Costa, Institut de Pharmacologie Moléculaire et Cellulaire, IPMC, CNRS, UMR, Valbonne, France. (2005/06/24 - 2005/06/24)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004 - 2004 "Molecular mechanisms of neuronal degeneration in Down’s syndrome and Alzheimer’s disease" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 26 November 2004. Speaker: Jorge Busciglio, University of California, Irvine, USA. (2004/11/26 - 2004/11/26)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2017/11/10 - Atual Módulo de formação TIPs “II.III.I – Ensino em Grandes Grupos (Aulas Teóricas)”, Gabinete de Educação Médica, Faculdade de Medicina, Universidade de Coimbra, Portugal, 10 de novembro 2017. Course TIPs “II.III.I – teaching for large groups (theoretical classes)”, Medical Education Office, Faculty of Medicine, University of Coimbra, Portugal
Oficina (workshop)
Módulo de formação TIPs “II.III.I – Ensino em Grandes Grupos (Aulas Teóricas)”
Universidade de Coimbra, Portugal
2004 - Atual Science Communication Science dissemination activities (laboratorial and other activities for students and general audiences) at the Center region of Portugal
Outro
Brain Awareness Week", "Ciencia Viva at Summer Holidays", "Science and Technology Week", "European Night of Researchers",
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1992 - Atual Poster communication Co-author of more than 100 poster presentations in national and international scientific meetings
Congresso
na
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1992 - Atual Oral communications Co-author of more than 50 oral presentations in national and international scientific meetings
Congresso
na
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/09/01 - 2008/09/12 Curso “ciência dos animais de laboratório” / training in "Science of laboratory animals" Curso acreditado pela FELASA (nº 020/08) seguindo as recomendações deste organismo para a formação e treino de pessoas para manipulação de animais de laboratório na categoria C (80 horas). Atribuição pela Direcção Geral de Veterinária de acreditação como Investigadora-Coordenadora
Outro
Curso “Ciência de Animais de Laboratório”
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/12/13 - 2007/12/14 Curso “The Teaching Improvement Project”, Departamento de Educação Médica, Faculdade de Medicina, Universidade de Coimbra, Portugal Course “The Teaching Improvement Project”, Medical Education Department, Faculty of Medicine, University of Coimbra, Portugal
Oficina (workshop)
The Teaching Improvement Project
Universidade de Coimbra, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2020/12/15 Role of damaged lysosomes on endothelial cells during heart failure with preserved ejection fraction development
Presidente do júri
Carlos Daniel Ferreira Rafael Pita (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/03/10 Dysfunctional dendritic and axonal activity in Alzheimer's disease - identifying possible therapeutic targets
Arguente principal
Alexandra Lopes Ramos Rodrigues (Outro)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/01/09 The role of ageing in polyglutamine-induced neurodegeneration. A Study in Machado -joseph disease models
Arguente
Dina Maria da Silva Rodrigues Pereira (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/11 On the persistence of therapy: the potential of miRNA modulation in Alzheimer's disease
Vogal
Ana Teresa de Barros Viegas (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/10/17 Role of amyloid-beta peptide on calcium and mitochondrial dyshomeostasis in hippocampal neurons: role of histone deacetylases
Arguente principal
Daniela Marinho Lopes (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2019/09 The changing brain in Alzheimer's disease: is the retina a mirror of disease onset and progression?
Arguente principal
Samuel Filipe Duarte Chiquita (Doutoramento)
Universidade do Porto, Portugal
2018/10 Chemo-enzymatic synthesis of new flavonoid derivatives with anti-inflammatory activity
Arguente principal
Joana Filipa Catarino Alves (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/10 Effect of essential oils and their major compounds on endothelial dysfunction associated with pulmonary arterial hypertension
Arguente principal
Julia Pereira Barbeitos (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09 Pesquisa de biomarcadores nas doenças de Alzheimer e Parkinson: uma abordagem proteómica às PBMCs
Presidente do júri
Rafael Ribeiro Santos Silva (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09 Deregulated inflammasome in Bipolar Disorder (BD): a matter of stress?
Orientador
Ana Catarina Pereira (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09 Validation of a siRNA targeting PI3KCA gene towards colorectal cancer therapy
Orientador
Rute Alexandra Henriques Tavares (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/07 Cellular and Molecular Biology
Arguente principal
Cristiano Filipe Brás de Sousa (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/07 Neurosciences
Arguente principal
Leonor Pedro Oliveira Ribeiro Rodrigues (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/06 Cardiovascular Sciences
Presidente do júri
Alexandre Manuel Monteiro Gonçalves (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 Cellular and Molecular Biology
Presidente do júri
Ricardo Alexandre Fróis Martins (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 Strategies to reverse cellular senescence and enhance progerin clearance in Hutchinson-Gilford Progeria Syndrome
Presidente do júri
Ana Sofia Marques Leal (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 The interaction of Giardia lamblia with macrophage cells: the action of parasite proteases on iNOS, COX-2 and p65RelA inflammatory proteins
Presidente do júri
Ágata Filipa Bandeira Lourenço (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 Cellular and Molecular Biology
Presidente do júri
Ana Rita Abrantes Dias (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 Glucocorticoid effects in the developing brain : a road to neuropsychiatric disorders
Presidente do júri
Helena Alexandra Ribeiro de Carvalho Pinheiro (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 Repeated systemic transplantation of mesenchymal stromal cells : a therapeutic strategy for Machado-Joseph Disease?
Presidente do júri
Adriana Isabel do Vale Marcelo (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 Circuitos envolvidos no desencadeamento da ejaculação em ratinhos (Mus musculus)
Orientador
Ana Rita Pimentel (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 Cellular and Molecular Biology
Presidente do júri
Joana Filipa Almeida Perdigão (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 Cellular and Molecular Biology
Presidente do júri
João Afonso Azevedo Pereira da Silva (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/07 O papel dos miRNAs na sobrevivência celular
Orientador
Catia Alexandra Seabra Vieira (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/07 Cellular and Molecular Biology
Presidente do júri
Sara Filipa Pereira Cruz (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/07 Neurosciences/neurodegenerative diseases
Arguente principal
Diogo Miguel Matos Vila Verde (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/02 Cellular and Molecular Biology
Presidente do júri
Mónicas Francisco Silva (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09 Resposta de célula endotelial à desregulação proteostática: avaliação da ação protetora da grelina
Orientador
Daniela Alexandra Dinis Costa (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09 Modulação da dinâmica mitocondrial pelo vírus Influenza A
Orientador
Inês Veríssimo (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09 Cellular and Molecular Biology
Presidente do júri
Joana Filipa Pereira Ferreira (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09 Cellular and Molecular Biology
Presidente do júri
André Emanuel Serra Lopes (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06 Cellular and Molecular Biology
Presidente do júri
Yolanda Sofia Pires Afonso (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06 Cellular and Molecular Biology
Presidente do júri
Ágata Filipa Bandeira Lourenço (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/03 Neurosciences
Arguente
Mariana Botelho da Rocha (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/02 Role of endoplasmic reticulum stress on Alzheimer's disease-associated neuronal and endothelial dysfunction
Orientador
Ana Isabel Plácido (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/12 Biotechnology
Arguente principal
Marta Isabel Heitor Cerejo (Doutoramento)
Universidade Nova de Lisboa, Portugal
2015/10 Endocytic trafficking mechanisms in Alzheimer’s disease: role of the actin regulators Bin1 and CD2AP
Orientador
Laura Nunes Soares Sequeira Salavessa (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/10 Role of reactive oxygen species in inflammasome activation in microglia under stress conditions
Orientador
Rafael Dias Azevedo (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09 Post-translational modifications of tau protein: implications for Alzheimer's disease
Arguente principal
Rui Miguel Ferreira Gomes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09 Cellular and Molecular Biology
Presidente do júri
Emanuel Lima (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09 Cellular and Molecular Biology
Presidente do júri
Rita Alexandra Pereira de Carvalho (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09 Cellular and Molecular Biology
Presidente do júri
Daniela Costa Batista de Almeida (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/07 Cellular and Molecular Biology
Arguente principal
Rui Mendes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/12 Neurosciences/Neurodegenerative diseases
Arguente principal
Dina Maria da Silva Rodrigues Pereira (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/10 Biotechnology
Arguente principal
Carla Tavares (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10 Technology
Arguente principal
Carla Anita Gomes Tavares (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/09 Cellular and Molecular Biology
Arguente principal
Marcos Schaan Profes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/03 Loss of proteostasis in brain endotelial cells in an in vitro model of Alzheimer’s disease
Orientador
Ana Catarina Fonseca (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/12 Cellular and Molecular Biology
Arguente principal
Patrícia Irene da Silva Inácio (Doutoramento)
Instituto Gulbenkian de Ciência, Portugal
2013/10 Technology
Arguente principal
Rita Videira (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/09 Cellular and Molecular Biology
Arguente principal
Valeria de Rosa (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09 Biochemistry
Arguente principal
Catarina Marques (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09 Biochemistry
Arguente principal
Catarina Marques (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/07 Cellular and Molecular Biology
Arguente principal
Rita Marisa Gomes Malheiros (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/07 Biochemistry
Arguente principal
Andreia Veríssimo Luís (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2013/07 Biochemistry
Arguente principal
Anna Pliássova (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/05 NMDA receptors-associated events and oxidative stress in models of Alzheimer’s disease
Orientador
Sandra Isabel Mota (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/12 Neurosciences/neurodegenerative disorders
Vogal
Daniela Arduíno (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/12 Cellular and Molecular Biology
Arguente principal
Paula isabel Meira Gonçalves (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2012/11 Neurosciences/neurodegenerative diseases
Vogal
Sónia Catarina de Sousa Correia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/07 Biochemistry
Arguente principal
Milene Gonçalves (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/06 Chromatin remodeling in Alzheimer’s disease pathogenesis
Orientador
Sueli Cristina Marques (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/11 Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors
Orientador
Rui Miguel Oliveira Costa (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/07 Cellular and Molecular Biology
Arguente principal
Bruno Vasconcelos (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/07 Biomedical Engineering
Arguente principal
Margarida Guerra (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/05 Neurosciences/Regenerative medicine
Arguente principal
Alexandra Rosa (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/11 Neurosciences
Arguente principal
Miguel Bajouco (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/07 Toxicity of amyloid-beta peptide in hypothalamic cells and protection by leptin and ghrelin. Implications for the etiopathogenesis of Alzheimer's disease
Orientador
Sílvia Gomes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07 Role of endothelial cells on survival of mature neurons. Implications for the etiopathogenesis of Alzheimer’s disease
Orientador
Ana Isabel Plácido (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07 Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease
Orientador
Isaura Vanessa Martins (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07 Neurosciences/neurodegenerative disorder
Arguente principal
Diana Silva (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07 Cellular and Molecular Biology
Arguente principal
Ana Soraia Barão (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07 Cellular and Molecular Biology
Arguente principal
Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/03 From cerebrovascular alterations to therapeutical options in Alzheimer's disease
Arguente principal
Daniel Ramos Andrade (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2009/11 Neurosciences/Neurodegenerative disorders
Arguente principal
João Pedro Lopes (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09 Validating microtubules as a potential neuroprotective target – effect of microtubule-interacting agents in a NGF deprivation model
Arguente principal
António José Folgado Laranjeira (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/06 Neuroprotective effects of statins in an in vitro model of Alzheimer’s disease
Orientador
Ana Catarina Fonseca (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/12 Neurotoxicity induced by amyloid-beta peptide. The role of different assembies
Orientador
Rosa Maria Matos Branco Resende (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2008/07 Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer’s and Prion’s diseases
Orientador
Elisabete Batista Ferreiro (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019 - Atual International Journal of Molecular Sciences (1422-0067) MDPI AG
2014 - Atual Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media SA

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2005 - Atual "L'Oréal for Women in Science" Prize (L'Oréal/UNESCO/FCT)
Avaliador
Fundação para a Ciência e a Tecnologia, Portugal L'Oréal SA
2000 - Atual Invited reviewer of international journals (e.g. Biochimica Biophysica Acta (BBA); British Journal of Pharmacology; Cell Death and Differentiation; Current Alzheimer’s Research; European Journal of Neuroscience; Experimental Neurology; Free Radical Biology & Medicine; International Journal of Alzheimer’s Disease; Journal of Aging Research; Journal of Alzheimer’s Disease; JNeurobiology of Aging; Neurobiology of Disease; The Journal of Neuroscience; The Journal of Pathology; Therapeutical Journal of Experimental Medicine)
Avaliador
2014 - 2016 Evaluation panels PhD and post-doc grants "Experimental Biology and Biochemistry" (2014 and 2015); final reports Neurosciences, Aging and Degenerative Disorders" (2014-2016)
Avaliador
Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2003 - 2015 Evaluation board of international research agencies Agence Nationale de la Reserche (ANR), França (2015) Deutsche Forschungsgemeinschaft (DFG), Alemanha (2015) Alzheimer’s Association, USA (2003, 2010, 2011, 2012, 2013) Szech Science Foundation, República Checa (2008, 2013) Research into Ageing, UK (2008) Ministry of Science and Technological Development of the Republic of Serbia, Sérvia (2010) FONDAZIONE TELETHON, Itália (2013) Medical Research Council, UK (2014)
Avaliador

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/09 - Atual "Doenças do neurodesenvolvimento, psiquiatria e saúde mental/Neurodeveleopment, psychiatry and mental health diseases" Master in Molecular and Translational Neurosciences (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/09 - Atual "Mecanismos de disfunção neuronal e neurodegenerescência"Mechanisms of neuronal dysfunction and neurodegeneration" Master in Molecular and Translational Neurosciences (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - Atual Bioquímica I / Biochemistry I (collaborator pratical classes) Integrated Master in Medicine (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - Atual Investigação Aplicada I / Applied Research I (Regent) Integrated Master in Medicine (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - Atual "Fundamentos de Neurociências/Principals of Neurosciences" Integrated Master in Medicine (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - Atual "Métodos e Técnicas de Investigação/Research Methods and Techniques” Master in Biomedical Research (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - Atual “Projeto Integrado Multidisciplinar (PIM)/Multidisciplinar Integrated Project”). Master in Biomedical Research (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - Atual "Métodos e Técnicas de Investigação/Research Methods and Techniques" Doctoral Program in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2012 - Atual Biologia do Envelhecimento / Biology of Aging (collaborator) Ciências de Engenharia Biomédica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Atual Neurobiologia II / Neurobiology II (collaborator) Ciências de Engenharia Biomédica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Atual Neurobiologia I / Neurobiology I (collaborator or regent every 2 years) Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - Atual "Neurociência/Neuroscience" (Professor Titular/Regent) Physiotherapy (Ensino básico 1º ciclo) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2009 - 2015 Neurobiologia / Neurobiology (Professor titular/regent) Análises Clínicas e de Saúde Pública (Bacharelato) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2018 A prevalência e incidência das doenças neurodegenerativas. Pereira C., Pereira A.C., Sousa F., Moreira P.I., Cardoso S.M., Rego A.C. Crónica Diário de Coimbra “Exercício saudável para neurónios saudáveis”, Ciência do CNC nos Jogos Europeus Universitários 2018. Diário de Coimbra
2012/10 Cérebro e memória- comentário por convite Porque é difícil escolher?

Entrevista / Programa (rádio / tv)

Programa Tema
2006/09 - 2006/09 Sociedade Civil Alzheimer
2005/05 - 2005/05 Entre Nós Alzheimer
2005/04 - 2005/04 Portugueses Excelentíssimos Alzheimer

Membro de associação

Nome da associação Tipo de participação
2000 - Atual Sociedade Portuguesa de Neurociências (SPN) (http://www.spn.org.pt/) Member
2017 - 2019 Associação de Pais e Encarregados de Educação, Escola Secundária José Falcão, Coimbra, Portugal Membro da Direção
2015 - 2017 Associação de Pais e Encarregados de Educação, Escola Secundária Infanta D. Maria, Coimbra, Portugal Presidente

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2019/11 - Atual Assessora do Vice-Diretor para a Investigação, Faculdade de Medicina, Universidade de Coimbra, Portugal
Consultor
Universidade de Coimbra Faculdade de Medicina, Portugal
2007 - Atual Principal Investigator - sub-group "Endoplasmic reticulum (ER) stress response and ER-mitochondria axis", CNC, University of Coimbra, Portugal
Coordenador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - 2026 UC-coordinated EU-funded MIA-Portugal project aimed to create the Multidisciplinary Institute of Ageing (MIA) that will be integrated into the Ageing@Coimbra Vitality Campus, a European Innovation Partnership on Active and Healthy Aging reference site
Membro
Universidade de Coimbra, Portugal
2019 - 2021 Membro da Assembleia da Faculdade de Medicina, Universidade de Coimbra, Portugal
Membro
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2020 Group leader "Cell signaling and metabolism in disease" (turnover every 2 years between PIs), Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal
Coordenador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2019 “ERA@UC – Enhancing Research in Ageing at the University of Coimbra” - selection of ERA Chair holder
Membro
Universidade de Coimbra Faculdade de Medicina, Portugal
2012 - 2015 Membro da Direção do Gabinete de Apoio à Investigação (GAI), Faculdade de Medicina, Universidade de Coimbra, Portugal Board member "Research Support Office", Faculty of Medicine, University of Coimbra, Portugal
Membro
Universidade de Coimbra Faculdade de Medicina, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2013 - Atual Evaluation board to select project fellows: - “InPaCTus” Innovative products and Technologies. COMPETE2020 nº 21874, collaboration with Navigator Paper Figueira, S.A. and RAIZ - “HealthyAging2020” project, ref. CENTRO-01-0145-FEDER-000012 (FEDER- CENTRO2020) - “Study of tTherapeutic Properties of Spring Thermal Waters- Dermocosmetics” project, Âncora Inovação do Programa PROVERE de Valorização das Estâncias Termais da Região Centro (FEDER- CENTRO2020) - "Neurosciences Matero Belard 2013" award Universidade de Coimbra, Portugal
Distinções

Prémio

2017 Edgar Cruz e Silva Award (PI: Armanda Santos)
Fundação Edgar Cruz e Silva, Portugal
2012 Edgar Cruz e Silva Award (PI: Dora Brites)
Fundação Edgar Cruz e Silva, Portugal
2011 “Best Poster Award” at the “First PF2MUC Symposium”, Coimbra, Portugal.
Universidade de Coimbra Faculdade de Medicina, Portugal
2010 Aging and Cerebral Dementia, Alzheimer's disease Award (PI: E Ferreiro, post-doc)
Sociedade Portuguesa de Neurociências, Portugal
2007 Third Prize of “Best Poster Award” "5th International Congress on Vascular Dementia", Budapest, Hungary
2004 L´Oréal Award "For Women in Science" (L´Oréal/UNESCO/FCT)
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2021 Livro "Mulheres na Ciência" (3ª edição)
Ciência Viva, Portugal