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Cátia Filipa Lourenço Marques is an Invited Assistant Professor at the Faculty of Pharmacy and Researcher at the Center for Innovative Biomedicine and Biotechnology, University of Coimbra. She completed her Ph.D. in Health Sciences in 2011 (University of Coimbra) with a pioneer work devoted to studying the nitric oxide (NO) dynamics linked to the glutamatergic transmission in vivo in which she demonstrated the pivotal role of neuronal derived NO in the neurovascular coupling. Ever since her scientific activity has been mainly settled on studying the mechanism by which the brain regulates its blood supply and how the deregulation of this mechanism is linked to neuronal dysfunction and cognitive dysfunction in different conditions (eg. aging, vascular dementia, type 2 diabetes), exploring strategies to counteract this relationship. Cátia has published 2 book chapters and 35 papers (27 full papers) in peer-reviewed journals (19 in the top 20% (2 in the top 5%) of the respective research field, 2 in journals with IF>10). According to Scopus, she counts 970 citations (h-index: 21). Her work has been presented in several national/international scientific meetings where the merit has been recognized by invitations/selection for oral communications (14 as presenting) and endorsed by 11 prizes/awards. She actively participated in 13 projects and secured 2 FCT fellowships, she mentored/trained 9 undergraduate and graduate students (3PhD/1Masters) and is currently co-supervisor of one Ph.D. student (4th year). Also, she has been serving as an Ad-hoc reviewer/editor for >10 international top-ranking journals in her expertise area.
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Identificação

Identificação pessoal

Nome completo
Cátia Lourenço Marques

Nomes de citação

  • Lourenço, C.F.

Identificadores de autor

Ciência ID
621C-8349-BAE6
ORCID iD
0000-0002-0514-0198

Moradas

  • Rua Larga, 3004-504, Coimbra, Coimbra, Portugal (Profissional)
Produções

Publicações

Artigo em revista
  1. Gonçalves, J.S,.; Laranjinha, J.; Rocha, B.S.; Lourenço, C.F.. "Dietary Nitrate Supplementation and Cognitive Health: the nitric oxide-dependent neurovascular coupling hypothesis". Biochemical Society Transactions (2024):
    Aceite para publicação
  2. Dias, C.; Lourenço, C.F.; Laranjinha, J.; Ledo, A.. "Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite". Free Radical Biology and Medicine 193 (2022): 779-786. http://dx.doi.org/10.1016/j.freeradbiomed.2022.11.021.
    10.1016/j.freeradbiomed.2022.11.021
  3. Gonçalves, João S.; Seiça, Raquel M.; Laranjinha, João; Lourenço, Cátia F.. "Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats". Free Radical Biology and Medicine 193 (2022): 669-675. http://dx.doi.org/10.1016/j.freeradbiomed.2022.11.009.
    10.1016/j.freeradbiomed.2022.11.009
  4. Lourenço, Cátia F.; Laranjinha, João. "Nitric Oxide Pathways in Neurovascular Coupling Under Normal and Stress Conditions in the Brain: Strategies to Rescue Aberrant Coupling and Improve Cerebral Blood Flow". Frontiers in Physiology 12 (2021): http://dx.doi.org/10.3389/fphys.2021.729201.
    10.3389/fphys.2021.729201
  5. Mancini, Gianni; Dias, Candida; Lourenço, Catia F.; Laranjinha, Joao; de Bem, Andreza; Ledo, Ana. "A High Fat/Cholesterol Diet Recapitulates Some Alzheimer’s Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction". Journal of Alzheimer's Disease 82 4 (2021): 1619-1633. http://dx.doi.org/10.3233/jad-210122.
    10.3233/jad-210122
  6. Monteiro, Tiago; Dias, Cândida; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Almeida, M. Gabriela. "Microelectrode Sensor for Real-Time Measurements of Nitrite in the Living Brain, in the Presence of Ascorbate". Biosensors 11 8 (2021): 277. http://dx.doi.org/10.3390/bios11080277.
    10.3390/bios11080277
  7. Ledo, A; Lourenço, C.F.; Cadenas, E; Barbosa, R.M.; Laranjinha, J.. "The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration". Free Radical Biology and Medicine (2020): http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.005.
    10.1016/j.freeradbiomed.2020.11.005
  8. Laranjinha, J.; Nunes, C.; Ledo, A.; Lourenço, C.F.; Rocha, B.S.; Barbosa, R.M.. "The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling". Neurochemical Research (2020):
    Publicado • 10.1007/s11064-020-03015-0
  9. Lourenço, Cátia F.; Caetano, Miguel; Ledo, Ana; Barbosa, Rui M.. "Platinized carbon fiber-based glucose microbiosensor designed for metabolic studies in brain slices". Bioelectrochemistry 130 (2019): 107325. http://dx.doi.org/10.1016/j.bioelechem.2019.06.010.
    10.1016/j.bioelechem.2019.06.010
  10. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry". Current Opinion in Electrochemistry 12 (2018): 129-140. https://doi.org/10.1016/j.coelec.2018.05.018.
    10.1016/j.coelec.2018.05.018
  11. Lourenço, Cátia F.; Ledo, Ana; Caetano, Miguel; Barbosa, Rui M.; Laranjinha, João. "Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.00913.
    10.3389/fphys.2018.00913
  12. Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices". Analytical Biochemistry 551 (2018): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047068802&partnerID=MN8TOARS.
    10.1016/j.ab.2018.05.010
  13. Cátia F. Lourenço; Ana Ledo; Greg A. Gerhardt; João Laranjinha; Rui M. Barbosa. "Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays". Scientific Reports 7 1 (2017): https://doi.org/10.1038/s41598-017-07119-6.
    10.1038/s41598-017-07119-6
  14. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Combined in Vivo Amperometric Oximetry and Electrophysiology in a Single Sensor: A Tool for Epilepsy Research". Analytical Chemistry (2017): https://doi.org/10.1021/acs.analchem.7b03452.
    10.1021/acs.analchem.7b03452
  15. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Christopher M. A. Brett; Greg A. Gerhardt; Rui M. Barbosa. "Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue". Analytical Chemistry 89 3 (2017): 1674-1683. https://doi.org/10.1021/acs.analchem.6b03772.
    10.1021/acs.analchem.6b03772
  16. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling". Experimental Neurology 291 (2017): 36-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011654048&partnerID=MN8TOARS.
    10.1016/j.expneurol.2017.01.013
  17. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration". Free Radical Biology and Medicine 108 (2017): 668-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018262522&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2017.04.026
  18. Dias, C.; Lourenço, C.F.; Ferreiro, E.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation". Neurobiology of Aging 46 (2016): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978903965&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2016.06.012
  19. Lourenço, C.F.; Ledo, A.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain". Sensors and Actuators, B: Chemical 237 (2016): 298-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976594136&partnerID=MN8TOARS.
    10.1016/j.snb.2016.06.083
  20. Ferreira NR; Lourenço CF; Barbosa RM; Laranjinha J. "Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: A novel functional interplay.". Brain Research Bulletin 114:13-9. (2015): 13-19. http://europepmc.org/abstract/med/25783673.
    10.1016/j.brainresbull.2015.03.002
  21. Ledo A; Lourenço CF; Caetano M; Barbosa RM; Laranjinha J. "Age-associated changes of nitric oxide concentration dynamics in the central nervous system of Fisher 344 rats.". Cellular and Molecular Neurobiology 35 1 (2015): 34. http://europepmc.org/abstract/med/25274046.
    10.1007/s10571-014-0115-0
  22. Lourenço, C.F.; Ledo, A.; Dias, C.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular and neurometabolic derailment in aging and alzheimer's disease". Frontiers in Aging Neuroscience 7 MAY (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84931266835&partnerID=MN8TOARS.
    10.3389/fnagi.2015.00103
  23. Lourenço CF; Santos RM; Barbosa RM; Cadenas E; Radi R; Laranjinha J. "Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide.". Free Radical Biology and Medicine 73 (2014): 421-429. http://europepmc.org/abstract/med/24887095.
    10.1016/j.freeradbiomed.2014.05.021
  24. Lourenço CF; Ferreira NR; Santos RM; Lukacova N; Barbosa RM; Laranjinha J. "The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortex and striatum.". Brain Research 1554 (2014): 1-11. http://europepmc.org/abstract/med/24495843.
    10.1016/j.brainres.2014.01.030
  25. Figueiras, E.; Oliveira, R.; Lourenço, C.F.; Campos, R.; Humeau-Heurtier, A.; Barbosa, R.M.; Laranjinha, J.; Requicha Ferreira, L.F.; De Mul, F.F.M.. "Self-mixing microprobe for monitoring microvascular perfusion in rat brain". Medical and Biological Engineering and Computing 51 1-2 (2013): 103-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874633368&partnerID=MN8TOARS.
    10.1007/s11517-012-0973-x
  26. Laranjinha, João; Santos, Ricardo M.; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Laranjinha, J.; Santos, R.M.; et al. "Nitric oxide signaling in the brain: translation of dynamics into respiration control and neurovascular coupling". Annals of the New York Academy of Sciences 1259 1 (2012): 10-18. http://dx.doi.org/10.1111/j.1749-6632.2012.06582.x.
    10.1111/j.1749-6632.2012.06582.x
  27. Santos, R.M.; Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Nitric oxide inactivation mechanisms in the brain: Role in bioenergetics and neurodegeneration". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863706810&partnerID=MN8TOARS.
    10.1155/2012/391914
  28. Santos RM; Lourenço CF; Gerhardt GA; Cadenas E; Laranjinha J; Barbosa RM. "Evidence for a pathway that facilitates nitric oxide diffusion in the brain.". Neurochemistry International 59 1 (2011): 90-96. http://europepmc.org/abstract/med/21672575.
    10.1016/j.neuint.2011.05.016
  29. Santos, R.M.; Lourenço, C.F.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Brain nitric oxide inactivation is governed by the vasculature". Antioxidants and Redox Signaling 14 6 (2011): 1011-1021. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951864475&partnerID=MN8TOARS.
    10.1089/ars.2010.3297
  30. LourençO, C.F.; Santos, R.; Barbosa, R.M.; Gerhardt, G.; Cadenas, E.; Laranjinha, J.. "In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus". Hippocampus 21 6 (2011): 622-630. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956360575&partnerID=MN8TOARS.
    10.1002/hipo.20774
  31. Barbosa, R.M; Jesus, ASL; Santos, R.M.; Pereira, C.; Lourenço, C.F.; Ferreira, N.R.; Ledo, A.; Laranjinha, J.. "Preparation, standardization and measurement of nitric oxide solutions". Global Journal of Analytical Chemistry 2 6 (2011): 176.
    Publicado
  32. Redondo-Horcajo M; Romero N; Martínez-Acedo P; Martínez-Ruiz A; Quijano C; Lourenço CF; Movilla N; et al. "Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide.". Cardiovascular Research 87 2 (2010): 356-365. http://europepmc.org/abstract/med/20106845.
    10.1093/cvr/cvq028
  33. Santos, R.M.; Lourenço, C.F.; Piedade, A.P.; Andrews, R.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue". Biosensors and Bioelectronics 24 4 (2008): 704-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-53049092283&partnerID=MN8TOARS.
    10.1016/j.bios.2008.06.034
  34. Lourenço, C.F.; Gago, B.; Barbosa, R.M.; De Freitas, V.; Laranjinha, J.. "LDL isolated from plasma-loaded red wine procyanidins resist lipid oxidation and tocopherol depletion". Journal of Agricultural and Food Chemistry 56 10 (2008): 3798-3804. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549089760&partnerID=MN8TOARS.
    10.1021/jf0733259
  35. Frank, J.; Budek, A.; Lundh, T.; Parker, R.S.; Swanson, J.E.; Lourenço, C.F.; Gago, B.; et al. "Dietary flavonoids with a catechol structure increase a-tocopherol in rats and protect the vitamin from oxidation in vitro1". Journal of Lipid Research 47 12 (2006): 2718-2725. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845570860&partnerID=MN8TOARS.
    10.1194/jlr.M600291-JLR200
  36. Pedro, M.; Lourenço, C.F.; Cidade, H.; Kijjoa, A.; Pinto, M.; Nascimento, M.S.J.. "Effects of natural prenylated flavones in the phenotypical ER (+) MCF-7 and ER (-) MDA-MB-231 human breast cancer cells". Toxicology Letters 164 1 (2006): 24-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646096970&partnerID=MN8TOARS.
    10.1016/j.toxlet.2005.11.007
Capítulo de livro
  1. Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Laranjinha, João. "Neurovascular Coupling Mediated by Neuronal Derived-Nitric Oxide: Mechanisms in Health and Dysfunction with Impact on Aging and Alzheimer’s Disease". In Biochemistry of Oxidative Stress, 289-308. Springer International Publishing, 2016.
    10.1007/978-3-319-45865-6_19
  2. Barbosa, R.M.; Lourenço, C.F.; Santos, R.M.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.. "In Vivo Real-Time Measurement of Nitric Oxide in Anesthetized Rat Brain". In Methods of Enzymology. 2008.
    10.1016/S0076-6879(08)01220-2
Poster em conferência
  1. João S Gonçalves; Raquel M. Seiça; João Laranjinha; Cátia F. Lourenço. "Neurovascular coupling and spatial memory are modulated by nitrate in a rat model of diabetes". Trabalho apresentado em BRAIN & BRAIN PET 2022 (accepted - TBD), 2022.
  2. João S Gonçalves; Raquel M. Seiça; João Laranjinha; Cátia F. Lourenço. "Impairment of neurovascular coupling and spatial memory in a rodent model of type 2 diabetes: impact of dietary nitrate intervention". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  3. Reva, Katerina; João S Gonçalves; Ana Raquel Santiago; João Laranjinha; Cátia F Lourenço. "Dietary nitrate, a metabolic precursor of nitric oxide, mitigates diabetic retinopathy in a type 2 diabetes rodent model". Trabalho apresentado em V Symposium of Portuguese Glial Network, 2021.
  4. Katerina Reva; Ana Raquel Santiago; João Laranjinha; Cátia F Lourenço. "Spatial navigation improvement induced by dietary nitrate in a chronic cerebral hypoperfusion rodent model is independent of visual function status.". Trabalho apresentado em no XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  5. Cátia F. Lourenço; João S. Gonçalves; José Sereno; João Sargento-Freitas; Castelo-Branco, Miguel; João Laranjinha. "Disruption of neurovascular coupling in a rodent model of vascular dementia – can we rescue it by nitrate supplementation?". Trabalho apresentado em 20th Biennial Meeting of SFRR International SFRR-I 2021, 2021.
  6. Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Tracking neurometabolic markers during seizure activity in awake rodents". Trabalho apresentado em Neuroscience 2019 - Chicago, 2019.
  7. Gonçalves, J.S,.; Lourenço, C.F.; Laranjinha, J.. "The nitrate-nitrite-nitric oxide pathway as rescuing mechanisms of cerebral dysfunction in a rodent model of vascular dementia". Trabalho apresentado em SFRR-E Meeting Ferrara 2019 (Ferrara, Italy), 2019.
  8. Barbosa, R.M.; Lourenço, C.F.; Nunes, C.; Manaia, M.; Ferreira, N.R.; Laranjinha, J.; Ledo, A.. "Monitoring Hydrogen Peroxide in Biological Media: Electrochemical Sensing Approaches". Trabalho apresentado em SFRR-E Meeting Ferrara 2019 (Ferrara, Italy), 2019.
  9. Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Ledo, A.; Laranjinha, J.. "Nitrite modulates mitochondrial respiration in brain ischemia/reperfusion". Trabalho apresentado em SFRR-E FERRARA MEETING 2019 (Ferrara, Italy), 2019.
  10. Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Aberrant changes in oxygen levels in the brain during Seizures in awake freely behaving rodents.". Trabalho apresentado em Europhysiology 2018 (London, UK), 2018.
  11. Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Simultaneous recording of neurometabolic changes and local field potential in central nervous system in awake behaving rodent models of epilepsy". Trabalho apresentado em 11th FENS Forum of Neuroscience (Berlin, Germany), 2018.
  12. Ledo, A.; Lourenço, C.F.; Nunes, C.; Santos, D.; Barbosa, R.M.. "Electrochemical (bio)sensors for high-resolution measurements of hydrogen peroxide in biological media". Trabalho apresentado em 19th SFRRI Biennial Meeting (Lisboa, Portugal), 2018.
  13. Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent impairment of the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic mouse model of Alzheimer's disease". Trabalho apresentado em 19th SFRRI Biennial Meeting (Lisboa, Portugal), 2018.
  14. Dias, C.; Monteiro, T.; Lourenço, C.F.; Ledo, A.; Almeida, M.G.; Laranjinha, J.; Barbosa, R.M.. "Probing nitrite and nitric oxide biochemistry in the brain in vivo by a novel sensing approach.". Trabalho apresentado em Joint meeting of the International Society of Neurochemistry and the European Society for Neurochemistry (Paris, France), 2017.
  15. Barbosa, R.M.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Ledo, A.. "Monitoring neurometabolic markers in vivo with electrochemical microsensor arrays". Trabalho apresentado em 68th Annual Meeting of the International Society of Electrochemistry. (Providencia, USA)., 2017.
  16. Monteiro, T.; Dias, C.; Lourenço, C.F.; Ledo, A.; Almeida, G.. "Micro(bio)sensing tools for nitrite detection in the brain.". Trabalho apresentado em International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society (Lion, France), 2017.
  17. Lourenço, C.F.; Ledo, A.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Alterations in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer’s disease are age-dependent and affect neurometabolic regulation". Trabalho apresentado em XIX National Congress of Biochemistry (Guimarães, Portugal), 2016.
  18. Huettl, P.; Ledo, A.; Lourenço, C.F.; Hampson, R.E.; Deadwyler, S.A.; Laranjinha, J.; Barbosa, R.M.; Gerhardt, G.A.. "Optimising biomorphic microelectrode arrays for electrophysiological and neurochemical recordings". Trabalho apresentado em Neuroscience 2016, Society for Neuroscience (San Diego, USA), 2016.
  19. Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Huettl, P.; Pomerleau, F.; Barbosa, R.M.; Gerhardt, G.A.. "Simultaneous recording of neurometabolic changes and local field potential-related currents in rodent models of Epilepsy.". Trabalho apresentado em Neuroscience 2016 (San Diego, USA)., 2016.
  20. Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Monitoring metabolic changes in the central nervous system of awake behaving rodent models of epilepsy". Trabalho apresentado em Monitoring Molecules in Neuroscience 2016, 2016.
  21. Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Neurometabolic Coupling: from Glutamate Neurotransmission to Oxygen and Glucose. Enzyme-Modified Microelectrodes for Monitoring Neurochemicals In Vivo.". Trabalho apresentado em 9th World Congress International Brain Research Organization (Rio de Janeiro, Brazil), 2015.
  22. Laranjinha, J.; Lourenço, C.F.; Ferreira, N.R.. "Nitric oxide-mediated neurovascular coupling in Alzheimer disease and under metabolic acidosis.". Trabalho apresentado em European Society for Neurochemistry's Conference (Tartu, Estonia), 2015.
  23. Barbosa, R.M.; Ledo, A.; Lourenço, C.F.; Ferreira, N.R.; Gerhardt, G.A.; Laranjinha, J.. "Microelectrode-based sensors and biosensors for high resolution measurements of neurochemicals in the brain". Trabalho apresentado em n Oxygen Club of California World Congress 2015 Oxidants and Antioxidants in Biology (Valencia, Spain), 2015.
  24. Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Neurometabolic Changes in the Central Nervous System of Awake Behaving Rodent Models of Epilepsy.". Trabalho apresentado em Oxygen Club of California World Congress 2015 Oxidants and Antioxidants in Biology (Valencia, Spain), 2015.
  25. Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the NMDAr-NO pathway in the hippocampus of a triple transgenic mouse model of Alzheimer´s disease: implications for neurometabolic regulation". Trabalho apresentado em In Oxygen Club of California World Congress 2015 Oxidants and Antioxidants in Biology (Valencia, Spain), 2015.
  26. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Derailment in nitric oxide-dependent neurovascular and neurometabolic coupling in aging". Trabalho apresentado em XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function., 2015.
  27. Lourenço, C.F.; Ledo, A.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Oxidase-based microbiosensor for real time monitoring of glucose and neuronal activity in awake behaving animals". Trabalho apresentado em XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function., 2015.
  28. Barbosa, R.M.; Lourenço, C.F.; Ledo, A.; Caetano, M.; Ferreira, N.R.; Gerhardt, G.A.; Laranjinha, J.. "Design of implantable enzyme-based microelectrodes for real-time measurements of neurochemicals and metabolic markers in vivo in the rat brain.". Trabalho apresentado em 4th International Conference on Bio-Sensing Technology (Lisboa, Portugal), 2015.
  29. Miranda, S.; Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "The fluctuations of nitric oxide and O2 in rat hippocampus with functional implications for neurometabolism". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
  30. Ferreira, N.R.; Lourenço, C.F.; Costa, S.M.; Barbosa, R.M.; Laranjinha, J.. "Nitrite is a precursor of nitric oxide in the brain hippocampus of living animals via redox interaction with ascorbate. An in vivo study in real-time.". Trabalho apresentado em In XVIII Congress of the Portuguese Biochemical (Coimbra, Portugal), 2014.
  31. Ledo, A.; Lourenço, C.F.; Caetano, M.; Barbosa, R.M.; Laranjinha, J.. "The glutamate-nNOS-nitric oxide pathway is impaired in aging. An in vivo study in Fisher 344 rats.". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
  32. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Impaired nitric oxide-mediated neurovascular coupling is an early functional deficiency in Alzheimer’s disease: an in vivo study in a rodent model.". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
  33. Ferreira, N.R.; Lourenço, C.F.; Costa, S.A.; Laranjinha, J.; Barbosa, R.M.. "Simultaneous Measurements of Ascorbate and Glutamate In Vivo in the Rat Brain.". Trabalho apresentado em 65th Annual meeting of the International Society of Electrochemistry (Lausanne, Switzerland), 2014.
  34. Caetano, M; Lourenço, C.F.; Santos, R.M.; Laranjinha, J.; Barbosa, R.M.. "Development of Carbon Fiber Microelectrode-Based Biosensor for Glucose Measurement In Vivo in the Brain.". Trabalho apresentado em Symposium of the Analytical Division of SPQ (Coimbra, Portugal), 2014.
  35. Lourenço, C.F.; Davis, V.A.; Batten, S.R.; Quintero, G.; Pormeleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Teasing apart Nitric Oxide’s role in erection: how hard can it be?". Trabalho apresentado em Neuroscience 2013 (San Diego, USA), 2013.
  36. Ferreira, N.R.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.. "The redox interplay between nitrite, ascorbate and nitric oxide in the brain". Trabalho apresentado em XIII meeting of the Portuguese Society for Neurosciences (Luso, Portugal), 2013.
  37. Lourenço, C.F.; Caetano, M; Ledo, A.; Laranjinha, J.; Barbosa, R.M.. "Matching oxygen and glucose dynamics during neurovascular coupling in rat hippocampus". Trabalho apresentado em XIII meeting of the Portuguese Society for Neurosciences (Luso, Portugal), 2013.
  38. Lourenço, C.F.; Barbosa, R.M.; Cadenas, E.; Rafael Radi; Laranjinha, J.. "Neuronal-nitric oxide dynamics and coupled neurovascular coupling in Alzheimer Disease and Aging.". Trabalho apresentado em Gordon Research Conference on Oxidative Stress and Disease (Les Diablerets, Switzerland), 2013.
  39. Ferreira, N.R; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.. "Nitric oxide bridges glutamatergic activity and ascorbate release to the extracellular space in the rat hippocampus". Trabalho apresentado em Conference Monitoring Molecules in Neuroscience (London, UK), 2012.
  40. Santos, R.M; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M. "Nitric Oxide and L-Glutamate Concentration Profiles in the Rat Hippocampus: Temporal and Spatial Relationship". Trabalho apresentado em Neuroscience 2011 (Washington, USA), 2011.
  41. Laranjinha, J.; Lourenço, C.F.; Cadenas, E.; Radi, R.; Barbosa, R.M.. "Neurovascular coupling in Alzheimer´s disease: in vivo and real-time measurement of nitric oxide and cerebral blood flow.". Trabalho apresentado em 23rd Biennial Meeting of ISN-ESN (Athens, Greece), 2011.
  42. Lourenço, C.F.; Laranjinha, J.; Cadenas, E.; Radi, R.; Barbosa, R.M.. "Brain microcirculation is regulated by neuronal-derived nitric oxide: real time and in vivo demonstration". Trabalho apresentado em Annual Meeting of the Physiological Society, Physiology 2011 (Oxford, UK), 2011.
  43. Lourenço, C.F.; Santos, R.M.; Barbosa, R.M.; Cadenas, E.; Laranjinha, J.. "Nitric oxide dynamics couples neuronal activity with hippocampus microcirculation: a mechanism impaired in a triple-transgenic mouse model of Alzheimer disease". Trabalho apresentado em XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function (Barcelona, Spain), 2011.
  44. Lourenço, C.F.. "Assessing Nitric Oxide Diffusion in the Brain: How diffusible is this messenger". Trabalho apresentado em XVII Congresso Nacional de Bioquímica (Porto, Portugal), 2010.
  45. Nuno Ricardo Ferreira; Lourenço, C.F.; Ricardo Miguel Santos; Ana Ledo; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "In Vivo Monitoring of Nitric Oxide in the Rat Brain: Characterization of a Carbon Fiber Microelectrode Based Probe". Trabalho apresentado em XVII Congresso Nacional de Bioquímica (Porto, Portugal), 2010.
  46. Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Neurovascular coupling in hippocampus of a triple-transgenic mouse model of Alzheimer disease.". Trabalho apresentado em XVII Congresso Nacional de Bioquímica (Porto, Portugal), 2010.
  47. Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Experimental Evidence for a Facilitated Nitric Oxide Diffusion In Vivo in the Brain". Trabalho apresentado em Neuroscience 2010, San Diego, Estados Unidos da América, 2010.
  48. Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Nitric oxide in rat hippocampus: is a free radical the key of neurovascular coupling?". Trabalho apresentado em International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
  49. Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Probing neurovascular coupling in the hippocampus using an array of nitric oxide microelectrode and a laser Doppler probe". Trabalho apresentado em 13th International Conference on In Vivo Methods, 2010.
  50. Rui Manuel Silva Barbosa; Ricardo Miguel Santos; Lourenço, C.F.; Ana Ledo; Greg A. Gerhardt; João António Nave Laranjinha. "Nanocomposite-modified Microelectrodes for Nitric Oxide Monitoring in vivo in the rat brain.". Trabalho apresentado em 61st Annual Meeting of the International Society of Electrochemistry- Electrochemistry from Biology to Physics, 2010.
  51. Mariano Redondo-Horcajo; Patrícia Martínez-Acedo; António Martínez-Ruiz; Cecilian Quijano; Lourenço, C.F.; N Movilla; JA Enriquez; et al. "Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide". Trabalho apresentado em International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
  52. Ricardo Miguel Santos; Lourenço, C.F.; Francois Pormeleau; Petter Huettl; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Nitric oxide inactivation in the central nervous system is governed by the vasculature". Trabalho apresentado em International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
  53. João António Nave Laranjinha; Lourenço, C.F.; Rafael Radi; Rui Manuel Silva Barbosa. "Neurovascular coupling between neuronal activity and blood flow in hippocampus mediated by nitric oxide". Trabalho apresentado em 4th European Society for Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, 2009.
  54. Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "In vivo concentration dynamics of nitric oxide in hippocampus and striatum of anesthetized rat following activation of glutamate receptors". Trabalho apresentado em 4th European Society for Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, 2009.
  55. Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "In Vivo inactivation of nitric oxide in the rat CNS: Quantitative and mechanistic features". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience., 2009.
  56. Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Nitric oxide mediates the neurovascular coupling between neuronal activity and blood flow in rat hippocampus: in vivo and direct evidence". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience, 2009.
  57. Rui Manuel Silva Barbosa; Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; João António Nave Laranjinha. "In vivo Inactivation of nitric oxide in CNS". Trabalho apresentado em 4th European Society for Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, 2009.
  58. Rui Manuel Silva Barbosa; Lourenço, C.F.; Ricardo Miguel Santos; Francois Pormeleau; Petter Huettl; Greg A. Gerhardt; João António Nave Laranjinha. "In Vivo Real Time Measurement of Nitric Oxide in Anesthetized Rat Brain". Trabalho apresentado em 59th Annual Meeting of the International Society of Electrochemistry., 2008.
  59. Ricardo Miguel Santos; Lourenço, C.F.; Ana Piedade; Roger Andrews; Francois Pormeleau; Petter Huettl; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "A Comparative Study of Carbon Fiber-Based Microelectrodes for the Measurement of Nitric Oxide in Brain Tissues". Trabalho apresentado em The 59th Annual Meeting of the International Society of Electrochemistry., 2008.
  60. Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "In vivo concentration dynamics of nitric oxide in anesthetized rat brain.". Trabalho apresentado em SFRR-Europe Summer School 2008., 2008.
  61. Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "In vivo real time kinetics of nitric oxide inactivation in the anesthetized rat brain". Trabalho apresentado em 6th Federation of European Neuroscience Societies Forum, 2008.
  62. Lourenço, C.F.. "In vivo concentration dynamics of nitric oxide in anesthetized rat brain". Trabalho apresentado em Meeting SFRR-Europe 2008, 2008.
  63. Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "P5. Regional nitric oxide concentration dynamics in the hippocampus of living rats evoked by stimulation of the glutamate receptors". Trabalho apresentado em Meeting SFRR-Europe 2007., 2007.
  64. Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Real time in vivo measurement of nitric oxide concentration dynamics in the rat hippocampus". Trabalho apresentado em Meeting SFRR-Europe 2007, 2007.
  65. Lourenço, C.F.; Ricardo Miguel Santos; Michel Stephens; Francois Pormeleau; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Real time in vivo measurement of nitric oxide microelectrodes in the CA1 and CA3 regions in the rat hippocampus.". Trabalho apresentado em 10th Meeting of the Portuguese Society for Neuroscience, 2007.
  66. Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Carbon fiber microelectrodes for in vivo electrochemical detection of neurochemicals". Trabalho apresentado em 6º Encontro da Divisão de Química Analítica da Sociedade Portuguesa de Química., 2007.
  67. Lourenço, C.F.; Bruno Gago; Joana Martins; João António Nave Laranjinha. "Phenols from red wine and olive oil recycle vitamin E in LDL particles, modulating its oxidizability in plasma". Trabalho apresentado em III Annual Meeting Center for Neurosciences and Cell Biology, 2005.
  68. Maria de São José Nascimento; Pedro, M.; Lourenço, C.F.; Madalena Pinto; Cidade, H.; Kijjoa, A.. "The effect of natural prenylated flavones on ER+ and ER- breast carcinoma cell lines.". Trabalho apresentado em Transmediterranean Colloquium on Heterocycle Chemistry TRAMECH 2004, 2004.
Resumo em conferência
  1. Lourenço, Cátia F.; Gonçalves, João; Sereno, José; Castelo-Branco, Miguel; Laranjinha, João. "Modulation of cerebrovascular dysfunction by dietary nitrate in a rodent model of vascular dementia". Trabalho apresentado em Society for Free Radical Research – EUROPE, Redox Biology in the 21st Century: A New Scientifc Discipline, 2021.
    10.1016/j.freeradbiomed.2021.08.059
  2. Lourenço, Cátia F.; Gonçalves, João; Sereno, José; Sargento-Freitas, João; Castelo-Branco, Miguel; Laranjinha, João. "Disruption of neurovascular coupling in a rodent model of vascular dementia – can we rescue it by nitrate supplementation?". Trabalho apresentado em 20th Biennial Meeting of SFRR International SFRR-I 2021 Society for Free Radical Research, 2021.
    Aceite para publicação • 10.1016/j.freeradbiomed.2020.12.408
  3. Gonçalves, João S.; Lourenço, Cátia F.; Laranjinha, João. "The nitrate-nitrite-nitric oxide pathway improves neurovascular coupling under cerebral hypoperfusion conditions". Trabalho apresentado em 20th Biennial Meeting of SFRR International SFRR-I 2021 Society for Free Radical Research, 2021.
    Aceite para publicação • 10.1016/j.freeradbiomed.2020.12.303
Tese / Dissertação
  1. Lourenço, C.F.. "In vivo Nitric Oxide Concentration Dynamics Induced by Glutamatergic Neuronal Activation in Rat Brain and Its Role In Neurovascular Coupling". Doutoramento, Universidade de Coimbra Faculdade de Farmácia, 2011.
  2. Lourenço, C.F.. "Biological activity of phenolic compounds from red wine and olive oil: interaction with LDL and modulation of nitric oxide production by endothelium". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.