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Identificação

Identificação pessoal

Nome completo
Cátia Lourenço Marques

Identificadores de autor

Ciência ID
621C-8349-BAE6
ORCID iD
0000-0002-0514-0198
Projetos

Bolsa

Designação Financiadores
2012 - 2019/02/28 Neuronal control of brain blood flow: nitric oxide as the neurovascular and neurometabolic coupler with impact in Azheimer´s disease and aging.
SFRH/BPD/82436/2011
Bolseiro de Pós-Doutoramento
2007 - 2011/02/28 Regulation of nitric oxide production and its biological impact in endothelial and neuronal cells
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBD2%F273332%F2006/PT
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2018 - Atual Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism based approach driven by nitrite and ascorbic acid from diet
POCI-01-0145-FEDER-29090
Investigador
Fundação para a Ciência e a Tecnologia
2018 - Atual Monitoring neurometabolic markers in vivo using microelectrode-based biosensors
POCI-01-0145-FEDER-028261
Investigador
Fundação para a Ciência e a Tecnologia
2013 - 2015 Nitric oxide is a master regulator of brain energetic metabolism: resolving aerobic glycolysis
PTDC / BBB-BQB / 3217/2012
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2013/03/31 Design of composite chemical sensors and biosensors for real-time and simultaneous monitoring of nitric oxide and oxygen in vivo in the brain.
iPTDC/SAU-BEB/103228/2008
Fundação para a Ciência e a Tecnologia
2010 - 2013 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/103538/PT
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
2010 - 2013 Neurovascular coupling between neuronal activity and blood flow in brain mediated by nitric oxide
PTDC/SAU-NEU/108992/2008
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
2010 - 2012/03 Development of a micro-probe for capillary laser Doppler flowmetry in rat brain
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/101726/PT
Fundação para a Ciência e a Tecnologia
2011 - 2012/01 Dietary Nitrate:Nitrite:Nitric oxide as a key pathway in gastrointestinal and cardiovascular physiology: uncovering new health properties of red wine and olive oil
PTDC/AGR-ALI/115744/2009
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2007 - 2010/05 New biological functions for wine polyphenols: cellular regulation and anti-inflammatory actions via nitric oxide production from dietary nitrite
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/71262/PT
Fundação para a Ciência e a Tecnologia
2004 - 2006 Dynamic interactions of phenolic compounds from wine and olive oil in plasma and lipoproteins with relevance for atherosclerosis prevention
info:eu-repo/grantAgreement/FCT/POCI/42418/PT
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Ledo, A; Lourenço, C.F.; Cadenas, E; Barbosa, R.M.; Laranjinha, J.. "The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration". Free Radical Biology and Medicine (2020): http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.005.
    10.1016/j.freeradbiomed.2020.11.005
  2. Laranjinha, J.; Nunes, C.; Ledo, A.; Lourenço, C.F.; Rocha, B.S.; Barbosa, R.M.. "The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling". Neurochemical Research (2020):
    Publicado • 10.1007/s11064-020-03015-0
  3. Lourenço, Cátia F.; Caetano, Miguel; Ledo, Ana; Barbosa, Rui M.. "Platinized carbon fiber-based glucose microbiosensor designed for metabolic studies in brain slices". Bioelectrochemistry 130 (2019): 107325. http://dx.doi.org/10.1016/j.bioelechem.2019.06.010.
    10.1016/j.bioelechem.2019.06.010
  4. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry". Current Opinion in Electrochemistry 12 (2018): 129-140. https://doi.org/10.1016/j.coelec.2018.05.018.
    10.1016/j.coelec.2018.05.018
  5. Lourenço, Cátia F.; Ledo, Ana; Caetano, Miguel; Barbosa, Rui M.; Laranjinha, João. "Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.00913.
    10.3389/fphys.2018.00913
  6. Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices". Analytical Biochemistry 551 (2018): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047068802&partnerID=MN8TOARS.
    10.1016/j.ab.2018.05.010
  7. Cátia F. Lourenço; Ana Ledo; Greg A. Gerhardt; João Laranjinha; Rui M. Barbosa. "Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays". Scientific Reports 7 1 (2017): https://doi.org/10.1038/s41598-017-07119-6.
    10.1038/s41598-017-07119-6
  8. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Combined in Vivo Amperometric Oximetry and Electrophysiology in a Single Sensor: A Tool for Epilepsy Research". Analytical Chemistry (2017): https://doi.org/10.1021/acs.analchem.7b03452.
    10.1021/acs.analchem.7b03452
  9. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Christopher M. A. Brett; Greg A. Gerhardt; Rui M. Barbosa. "Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue". Analytical Chemistry 89 3 (2017): 1674-1683. https://doi.org/10.1021/acs.analchem.6b03772.
    10.1021/acs.analchem.6b03772
  10. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling". Experimental Neurology 291 (2017): 36-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011654048&partnerID=MN8TOARS.
    10.1016/j.expneurol.2017.01.013
  11. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration". Free Radical Biology and Medicine 108 (2017): 668-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018262522&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2017.04.026
  12. Dias, C.; Lourenço, C.F.; Ferreiro, E.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation". Neurobiology of Aging 46 (2016): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978903965&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2016.06.012
  13. Lourenço, C.F.; Ledo, A.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain". Sensors and Actuators, B: Chemical 237 (2016): 298-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976594136&partnerID=MN8TOARS.
    10.1016/j.snb.2016.06.083
  14. Ferreira NR; Lourenço CF; Barbosa RM; Laranjinha J. "Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: A novel functional interplay.". Brain Research Bulletin 114:13-9. (2015): 13-19. http://europepmc.org/abstract/med/25783673.
    10.1016/j.brainresbull.2015.03.002
  15. Ledo A; Lourenço CF; Caetano M; Barbosa RM; Laranjinha J. "Age-associated changes of nitric oxide concentration dynamics in the central nervous system of Fisher 344 rats.". Cellular and Molecular Neurobiology 35 1 (2015): 34. http://europepmc.org/abstract/med/25274046.
    10.1007/s10571-014-0115-0
  16. Lourenço, C.F.; Ledo, A.; Dias, C.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular and neurometabolic derailment in aging and alzheimer's disease". Frontiers in Aging Neuroscience 7 MAY (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84931266835&partnerID=MN8TOARS.
    10.3389/fnagi.2015.00103
  17. Lourenço CF; Santos RM; Barbosa RM; Cadenas E; Radi R; Laranjinha J. "Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide.". Free Radical Biology and Medicine 73 (2014): 421-429. http://europepmc.org/abstract/med/24887095.
    10.1016/j.freeradbiomed.2014.05.021
  18. Lourenço CF; Ferreira NR; Santos RM; Lukacova N; Barbosa RM; Laranjinha J. "The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortex and striatum.". Brain Research 1554 (2014): 1-11. http://europepmc.org/abstract/med/24495843.
    10.1016/j.brainres.2014.01.030
  19. Figueiras, E.; Oliveira, R.; Lourenço, C.F.; Campos, R.; Humeau-Heurtier, A.; Barbosa, R.M.; Laranjinha, J.; Requicha Ferreira, L.F.; De Mul, F.F.M.. "Self-mixing microprobe for monitoring microvascular perfusion in rat brain". Medical and Biological Engineering and Computing 51 1-2 (2013): 103-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874633368&partnerID=MN8TOARS.
    10.1007/s11517-012-0973-x
  20. Laranjinha, João; Santos, Ricardo M.; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Laranjinha, J.; Santos, R.M.; et al. "Nitric oxide signaling in the brain: translation of dynamics into respiration control and neurovascular coupling". Annals of the New York Academy of Sciences 1259 1 (2012): 10-18. http://dx.doi.org/10.1111/j.1749-6632.2012.06582.x.
    10.1111/j.1749-6632.2012.06582.x
  21. Santos, R.M.; Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Nitric oxide inactivation mechanisms in the brain: Role in bioenergetics and neurodegeneration". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863706810&partnerID=MN8TOARS.
    10.1155/2012/391914
  22. Santos RM; Lourenço CF; Gerhardt GA; Cadenas E; Laranjinha J; Barbosa RM. "Evidence for a pathway that facilitates nitric oxide diffusion in the brain.". Neurochemistry International 59 1 (2011): 90-96. http://europepmc.org/abstract/med/21672575.
    10.1016/j.neuint.2011.05.016
  23. Santos, R.M.; Lourenço, C.F.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Brain nitric oxide inactivation is governed by the vasculature". Antioxidants and Redox Signaling 14 6 (2011): 1011-1021. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951864475&partnerID=MN8TOARS.
    10.1089/ars.2010.3297
  24. LourençO, C.F.; Santos, R.; Barbosa, R.M.; Gerhardt, G.; Cadenas, E.; Laranjinha, J.. "In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus". Hippocampus 21 6 (2011): 622-630. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956360575&partnerID=MN8TOARS.
    10.1002/hipo.20774
  25. Barbosa, R.M; Jesus, ASL; Santos, R.M.; Pereira, C.; Lourenço, C.F.; Ferreira, N.R.; Ledo, A.; Laranjinha, J.. "Preparation, standardization and measurement of nitric oxide solutions". Global Journal of Analytical Chemistry 2 6 (2011): 176.
    Publicado
  26. Redondo-Horcajo M; Romero N; Martínez-Acedo P; Martínez-Ruiz A; Quijano C; Lourenço CF; Movilla N; et al. "Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide.". Cardiovascular Research 87 2 (2010): 356-365. http://europepmc.org/abstract/med/20106845.
    10.1093/cvr/cvq028
  27. Santos, R.M.; Lourenço, C.F.; Piedade, A.P.; Andrews, R.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue". Biosensors and Bioelectronics 24 4 (2008): 704-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-53049092283&partnerID=MN8TOARS.
    10.1016/j.bios.2008.06.034
  28. Lourenço, C.F.; Gago, B.; Barbosa, R.M.; De Freitas, V.; Laranjinha, J.. "LDL isolated from plasma-loaded red wine procyanidins resist lipid oxidation and tocopherol depletion". Journal of Agricultural and Food Chemistry 56 10 (2008): 3798-3804. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549089760&partnerID=MN8TOARS.
    10.1021/jf0733259
  29. Frank, J.; Budek, A.; Lundh, T.; Parker, R.S.; Swanson, J.E.; Lourenço, C.F.; Gago, B.; et al. "Dietary flavonoids with a catechol structure increase a-tocopherol in rats and protect the vitamin from oxidation in vitro1". Journal of Lipid Research 47 12 (2006): 2718-2725. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845570860&partnerID=MN8TOARS.
    10.1194/jlr.M600291-JLR200
  30. Pedro, M.; Lourenço, C.F.; Cidade, H.; Kijjoa, A.; Pinto, M.; Nascimento, M.S.J.. "Effects of natural prenylated flavones in the phenotypical ER (+) MCF-7 and ER (-) MDA-MB-231 human breast cancer cells". Toxicology Letters 164 1 (2006): 24-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646096970&partnerID=MN8TOARS.
    10.1016/j.toxlet.2005.11.007
Capítulo de livro
  1. Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Laranjinha, João. "Neurovascular Coupling Mediated by Neuronal Derived-Nitric Oxide: Mechanisms in Health and Dysfunction with Impact on Aging and Alzheimer’s Disease". In Biochemistry of Oxidative Stress, 289-308. Springer International Publishing, 2016.
    10.1007/978-3-319-45865-6_19
  2. Barbosa, R.M.; Lourenço, C.F.; Santos, R.M.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.. "In Vivo Real-Time Measurement of Nitric Oxide in Anesthetized Rat Brain". In Methods of Enzymology. 2008.
    10.1016/S0076-6879(08)01220-2
Poster em conferência
  1. Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Tracking neurometabolic markers during seizure activity in awake rodents". Trabalho apresentado em Neuroscience 2019 (, 2019.
  2. Gonçalves, J.S,.; Lourenço, C.F.; Laranjinha, J.. "The nitrate-nitrite-nitric oxide pathway as rescuing mechanisms of cerebral dysfunction in a rodent model of vascular dementia". Trabalho apresentado em SFRR-E Meeting Ferrara 2019 (Ferrara, Italy), 2019.
  3. Barbosa, R.M.; Lourenço, C.F.; Nunes, C.; Manaia, M.; Ferreira, N.R.; Laranjinha, J.; Ledo, A.. "Monitoring Hydrogen Peroxide in Biological Media: Electrochemical Sensing Approaches". Trabalho apresentado em SFRR-E Meeting Ferrara 2019 (Ferrara, Italy), 2019.
  4. Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Ledo, A.; Laranjinha, J.. "Nitrite modulates mitochondrial respiration in brain ischemia/reperfusion". Trabalho apresentado em SFRR-E FERRARA MEETING 2019 (Ferrara, Italy), 2019.
  5. Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Aberrant changes in oxygen levels in the brain during Seizures in awake freely behaving rodents.". Trabalho apresentado em Europhysiology 2018 (London, UK), 2018.
  6. Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Simultaneous recording of neurometabolic changes and local field potential in central nervous system in awake behaving rodent models of epilepsy". Trabalho apresentado em 11th FENS Forum of Neuroscience (Berlin, Germany), 2018.
  7. Ledo, A.; Lourenço, C.F.; Nunes, C.; Santos, D.; Barbosa, R.M.. "Electrochemical (bio)sensors for high-resolution measurements of hydrogen peroxide in biological media". Trabalho apresentado em 19th SFRRI Biennial Meeting (Lisboa, Portugal), 2018.
  8. Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent impairment of the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic mouse model of Alzheimer's disease". Trabalho apresentado em 19th SFRRI Biennial Meeting (Lisboa, Portugal), 2018.
  9. Dias, C.; Monteiro, T.; Lourenço, C.F.; Ledo, A.; Almeida, M.G.; Laranjinha, J.; Barbosa, R.M.. "Probing nitrite and nitric oxide biochemistry in the brain in vivo by a novel sensing approach.". Trabalho apresentado em Joint meeting of the International Society of Neurochemistry and the European Society for Neurochemistry (Paris, France), 2017.
  10. Barbosa, R.M.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Ledo, A.. "Monitoring neurometabolic markers in vivo with electrochemical microsensor arrays". Trabalho apresentado em 68th Annual Meeting of the International Society of Electrochemistry. (Providencia, USA)., 2017.
  11. Monteiro, T.; Dias, C.; Lourenço, C.F.; Ledo, A.; Almeida, G.. "Micro(bio)sensing tools for nitrite detection in the brain.". Trabalho apresentado em International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society (Lion, France), 2017.
  12. Lourenço, C.F.; Ledo, A.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Alterations in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer’s disease are age-dependent and affect neurometabolic regulation". Trabalho apresentado em XIX National Congress of Biochemistry (Guimarães, Portugal), 2016.
  13. Huettl, P.; Ledo, A.; Lourenço, C.F.; Hampson, R.E.; Deadwyler, S.A.; Laranjinha, J.; Barbosa, R.M.; Gerhardt, G.A.. "Optimising biomorphic microelectrode arrays for electrophysiological and neurochemical recordings". Trabalho apresentado em Neuroscience 2016, Society for Neuroscience (San Diego, USA), 2016.
  14. Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Huettl, P.; Pomerleau, F.; Barbosa, R.M.; Gerhardt, G.A.. "Simultaneous recording of neurometabolic changes and local field potential-related currents in rodent models of Epilepsy.". Trabalho apresentado em Neuroscience 2016 (San Diego, USA)., 2016.
  15. Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Monitoring metabolic changes in the central nervous system of awake behaving rodent models of epilepsy". Trabalho apresentado em Monitoring Molecules in Neuroscience 2016, 2016.
  16. Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Neurometabolic Coupling: from Glutamate Neurotransmission to Oxygen and Glucose. Enzyme-Modified Microelectrodes for Monitoring Neurochemicals In Vivo.". Trabalho apresentado em 9th World Congress International Brain Research Organization (Rio de Janeiro, Brazil), 2015.
  17. Laranjinha, J.; Lourenço, C.F.; Ferreira, N.R.. "Nitric oxide-mediated neurovascular coupling in Alzheimer disease and under metabolic acidosis.". Trabalho apresentado em European Society for Neurochemistry's Conference (Tartu, Estonia), 2015.
  18. Barbosa, R.M.; Ledo, A.; Lourenço, C.F.; Ferreira, N.R.; Gerhardt, G.A.; Laranjinha, J.. "Microelectrode-based sensors and biosensors for high resolution measurements of neurochemicals in the brain". Trabalho apresentado em n Oxygen Club of California World Congress 2015 Oxidants and Antioxidants in Biology (Valencia, Spain), 2015.
  19. Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Neurometabolic Changes in the Central Nervous System of Awake Behaving Rodent Models of Epilepsy.". Trabalho apresentado em Oxygen Club of California World Congress 2015 Oxidants and Antioxidants in Biology (Valencia, Spain), 2015.
  20. Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the NMDAr-NO pathway in the hippocampus of a triple transgenic mouse model of Alzheimer´s disease: implications for neurometabolic regulation". Trabalho apresentado em In Oxygen Club of California World Congress 2015 Oxidants and Antioxidants in Biology (Valencia, Spain), 2015.
  21. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Derailment in nitric oxide-dependent neurovascular and neurometabolic coupling in aging". Trabalho apresentado em XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function., 2015.
  22. Lourenço, C.F.; Ledo, A.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Oxidase-based microbiosensor for real time monitoring of glucose and neuronal activity in awake behaving animals". Trabalho apresentado em XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function., 2015.
  23. Barbosa, R.M.; Lourenço, C.F.; Ledo, A.; Caetano, M.; Ferreira, N.R.; Gerhardt, G.A.; Laranjinha, J.. "Design of implantable enzyme-based microelectrodes for real-time measurements of neurochemicals and metabolic markers in vivo in the rat brain.". Trabalho apresentado em 4th International Conference on Bio-Sensing Technology (Lisboa, Portugal), 2015.
  24. Miranda, S.; Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "The fluctuations of nitric oxide and O2 in rat hippocampus with functional implications for neurometabolism". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
  25. Ferreira, N.R.; Lourenço, C.F.; Costa, S.M.; Barbosa, R.M.; Laranjinha, J.. "Nitrite is a precursor of nitric oxide in the brain hippocampus of living animals via redox interaction with ascorbate. An in vivo study in real-time.". Trabalho apresentado em In XVIII Congress of the Portuguese Biochemical (Coimbra, Portugal), 2014.
  26. Ledo, A.; Lourenço, C.F.; Caetano, M.; Barbosa, R.M.; Laranjinha, J.. "The glutamate-nNOS-nitric oxide pathway is impaired in aging. An in vivo study in Fisher 344 rats.". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
  27. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Impaired nitric oxide-mediated neurovascular coupling is an early functional deficiency in Alzheimer’s disease: an in vivo study in a rodent model.". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
  28. Ferreira, N.R.; Lourenço, C.F.; Costa, S.A.; Laranjinha, J.; Barbosa, R.M.. "Simultaneous Measurements of Ascorbate and Glutamate In Vivo in the Rat Brain.". Trabalho apresentado em 65th Annual meeting of the International Society of Electrochemistry (Lausanne, Switzerland), 2014.
  29. Caetano, M; Lourenço, C.F.; Santos, R.M.; Laranjinha, J.; Barbosa, R.M.. "Development of Carbon Fiber Microelectrode-Based Biosensor for Glucose Measurement In Vivo in the Brain.". Trabalho apresentado em Symposium of the Analytical Division of SPQ (Coimbra, Portugal), 2014.
  30. Lourenço, C.F.; Davis, V.A.; Batten, S.R.; Quintero, G.; Pormeleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Teasing apart Nitric Oxide’s role in erection: how hard can it be?". Trabalho apresentado em Neuroscience 2013 (San Diego, USA), 2013.
  31. Ferreira, N.R.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.. "The redox interplay between nitrite, ascorbate and nitric oxide in the brain". Trabalho apresentado em XIII meeting of the Portuguese Society for Neurosciences (Luso, Portugal), 2013.
  32. Lourenço, C.F.; Caetano, M; Ledo, A.; Laranjinha, J.; Barbosa, R.M.. "Matching oxygen and glucose dynamics during neurovascular coupling in rat hippocampus". Trabalho apresentado em XIII meeting of the Portuguese Society for Neurosciences (Luso, Portugal), 2013.
  33. Lourenço, C.F.; Barbosa, R.M.; Cadenas, E.; Rafael Radi; Laranjinha, J.. "Neuronal-nitric oxide dynamics and coupled neurovascular coupling in Alzheimer Disease and Aging.". Trabalho apresentado em Gordon Research Conference on Oxidative Stress and Disease (Les Diablerets, Switzerland), 2013.
  34. Ferreira, N.R; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.. "Nitric oxide bridges glutamatergic activity and ascorbate release to the extracellular space in the rat hippocampus". Trabalho apresentado em Conference Monitoring Molecules in Neuroscience (London, UK), 2012.
  35. Santos, R.M; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M. "Nitric Oxide and L-Glutamate Concentration Profiles in the Rat Hippocampus: Temporal and Spatial Relationship". Trabalho apresentado em Neuroscience 2011 (Washington, USA), 2011.
  36. Laranjinha, J.; Lourenço, C.F.; Cadenas, E.; Radi, R.; Barbosa, R.M.. "Neurovascular coupling in Alzheimer´s disease: in vivo and real-time measurement of nitric oxide and cerebral blood flow.". Trabalho apresentado em 23rd Biennial Meeting of ISN-ESN (Athens, Greece), 2011.
  37. Lourenço, C.F.; Laranjinha, J.; Cadenas, E.; Radi, R.; Barbosa, R.M.. "Brain microcirculation is regulated by neuronal-derived nitric oxide: real time and in vivo demonstration". Trabalho apresentado em Annual Meeting of the Physiological Society, Physiology 2011 (Oxford, UK), 2011.
  38. Lourenço, C.F.; Santos, R.M.; Barbosa, R.M.; Cadenas, E.; Laranjinha, J.. "Nitric oxide dynamics couples neuronal activity with hippocampus microcirculation: a mechanism impaired in a triple-transgenic mouse model of Alzheimer disease". Trabalho apresentado em XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function (Barcelona, Spain), 2011.
  39. Lourenço, C.F.. "Assessing Nitric Oxide Diffusion in the Brain: How diffusible is this messenger". Trabalho apresentado em XVII Congresso Nacional de Bioquímica (Porto, Portugal), 2010.
  40. Nuno Ricardo Ferreira; Lourenço, C.F.; Ricardo Miguel Santos; Ana Ledo; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "In Vivo Monitoring of Nitric Oxide in the Rat Brain: Characterization of a Carbon Fiber Microelectrode Based Probe". Trabalho apresentado em XVII Congresso Nacional de Bioquímica (Porto, Portugal), 2010.
  41. Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Neurovascular coupling in hippocampus of a triple-transgenic mouse model of Alzheimer disease.". Trabalho apresentado em XVII Congresso Nacional de Bioquímica (Porto, Portugal), 2010.
  42. Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Experimental Evidence for a Facilitated Nitric Oxide Diffusion In Vivo in the Brain". Trabalho apresentado em Neuroscience 2010, San Diego, Estados Unidos da América, 2010.
  43. Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Nitric oxide in rat hippocampus: is a free radical the key of neurovascular coupling?". Trabalho apresentado em International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
  44. Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Probing neurovascular coupling in the hippocampus using an array of nitric oxide microelectrode and a laser Doppler probe". Trabalho apresentado em 13th International Conference on In Vivo Methods, 2010.
  45. Rui Manuel Silva Barbosa; Ricardo Miguel Santos; Lourenço, C.F.; Ana Ledo; Greg A. Gerhardt; João António Nave Laranjinha. "Nanocomposite-modified Microelectrodes for Nitric Oxide Monitoring in vivo in the rat brain.". Trabalho apresentado em 61st Annual Meeting of the International Society of Electrochemistry- Electrochemistry from Biology to Physics, 2010.
  46. Mariano Redondo-Horcajo; Patrícia Martínez-Acedo; António Martínez-Ruiz; Cecilian Quijano; Lourenço, C.F.; N Movilla; JA Enriquez; et al. "Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide". Trabalho apresentado em International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
  47. Ricardo Miguel Santos; Lourenço, C.F.; Francois Pormeleau; Petter Huettl; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Nitric oxide inactivation in the central nervous system is governed by the vasculature". Trabalho apresentado em International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
  48. João António Nave Laranjinha; Lourenço, C.F.; Rafael Radi; Rui Manuel Silva Barbosa. "Neurovascular coupling between neuronal activity and blood flow in hippocampus mediated by nitric oxide". Trabalho apresentado em 4th European Society for Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, 2009.
  49. Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "In vivo concentration dynamics of nitric oxide in hippocampus and striatum of anesthetized rat following activation of glutamate receptors". Trabalho apresentado em 4th European Society for Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, 2009.
  50. Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "In Vivo inactivation of nitric oxide in the rat CNS: Quantitative and mechanistic features". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience., 2009.
  51. Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Nitric oxide mediates the neurovascular coupling between neuronal activity and blood flow in rat hippocampus: in vivo and direct evidence". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience, 2009.
  52. Rui Manuel Silva Barbosa; Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; João António Nave Laranjinha. "In vivo Inactivation of nitric oxide in CNS". Trabalho apresentado em 4th European Society for Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, 2009.
  53. Rui Manuel Silva Barbosa; Lourenço, C.F.; Ricardo Miguel Santos; Francois Pormeleau; Petter Huettl; Greg A. Gerhardt; João António Nave Laranjinha. "In Vivo Real Time Measurement of Nitric Oxide in Anesthetized Rat Brain". Trabalho apresentado em 59th Annual Meeting of the International Society of Electrochemistry., 2008.
  54. Ricardo Miguel Santos; Lourenço, C.F.; Ana Piedade; Roger Andrews; Francois Pormeleau; Petter Huettl; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "A Comparative Study of Carbon Fiber-Based Microelectrodes for the Measurement of Nitric Oxide in Brain Tissues". Trabalho apresentado em The 59th Annual Meeting of the International Society of Electrochemistry., 2008.
  55. Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "In vivo concentration dynamics of nitric oxide in anesthetized rat brain.". Trabalho apresentado em SFRR-Europe Summer School 2008., 2008.
  56. Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "In vivo real time kinetics of nitric oxide inactivation in the anesthetized rat brain". Trabalho apresentado em 6th Federation of European Neuroscience Societies Forum, 2008.
  57. Lourenço, C.F.. "In vivo concentration dynamics of nitric oxide in anesthetized rat brain". Trabalho apresentado em Meeting SFRR-Europe 2008, 2008.
  58. Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "P5. Regional nitric oxide concentration dynamics in the hippocampus of living rats evoked by stimulation of the glutamate receptors". Trabalho apresentado em Meeting SFRR-Europe 2007., 2007.
  59. Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Real time in vivo measurement of nitric oxide concentration dynamics in the rat hippocampus". Trabalho apresentado em Meeting SFRR-Europe 2007, 2007.
  60. Lourenço, C.F.; Ricardo Miguel Santos; Michel Stephens; Francois Pormeleau; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Real time in vivo measurement of nitric oxide microelectrodes in the CA1 and CA3 regions in the rat hippocampus.". Trabalho apresentado em 10th Meeting of the Portuguese Society for Neuroscience, 2007.
  61. Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Carbon fiber microelectrodes for in vivo electrochemical detection of neurochemicals". Trabalho apresentado em 6º Encontro da Divisão de Química Analítica da Sociedade Portuguesa de Química., 2007.
  62. Lourenço, C.F.; Bruno Gago; Joana Martins; João António Nave Laranjinha. "Phenols from red wine and olive oil recycle vitamin E in LDL particles, modulating its oxidizability in plasma". Trabalho apresentado em III Annual Meeting Center for Neurosciences and Cell Biology, 2005.
  63. Maria de São José Nascimento; Pedro, M.; Lourenço, C.F.; Madalena Pinto; Cidade, H.; Kijjoa, A.. "The effect of natural prenylated flavones on ER+ and ER- breast carcinoma cell lines.". Trabalho apresentado em Transmediterranean Colloquium on Heterocycle Chemistry TRAMECH 2004, 2004.
Tese / Dissertação
  1. Lourenço, C.F.. "In vivo Nitric Oxide Concentration Dynamics Induced by Glutamatergic Neuronal Activation in Rat Brain and Its Role In Neurovascular Coupling". Doutoramento, Universidade de Coimbra Faculdade de Farmácia, 2011.
  2. Lourenço, C.F.. "Biological activity of phenolic compounds from red wine and olive oil: interaction with LDL and modulation of nitric oxide production by endothelium". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.