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Dina Maria da Silva Rodrigues Pereira finished her Applied Biology Degree in 2008 at the University of Minho - School of Sciences. In January 2020 completed her Doctoral degree in Experimental Biology and Biomedicine from the Institute of Interdisciplinary Research of University of Coimbra (IIIUC) at Center for Neuroscience and Cell Biology (CNC-UC). With over 10 years of research experience in neuroscience, viral vectors, disease models, biotechnology in health, ageing and oncobiology, contributed to many peer-reviewed publications. Currently, is a Junior Researcher at the University of Coimbra - Center for Neuroscience and Cell Biology (CNC-UC)/ CIBB - Center for Innovative Biomedicine and Biotechnology in the Gene and Stem Cell Therapies for the Brain Group.
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Identificação

Identificação pessoal

Nome completo
Dina Maria da Silva Rodrigues Pereira

Nomes de citação

  • Pereira, Dina

Identificadores de autor

Ciência ID
6015-36DA-D03E
ORCID iD
0000-0002-6723-1159

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia
Formação
Grau Classificação
2020/01/09
Concluído
 Biologia Experimental e Biomedicina (Doutoramento)
Especialização em Biotecnologia e Saúde
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
""The role of ageing in polyglutamine-induced neurodegeneration. A study in Machado-Joseph disease models"" (TESE/DISSERTAÇÃO)
 Louvor e distinção por unanimidade
2008
Concluído
 Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Human Leukocyte Antigen Class I expression and infection by JC virus in right-sided colon cancer" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/07/01 - Atual Pós-doutorado (Investigação) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2020/02/01 - 2023/06/30 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/07/02 - 2012/09/30 Research trainee under the internal project: "Irradiation and atherosclerotic disease – epidemiologic and biologic evaluation of a cohort irradiated in childhood for tinea capitis treatment"- Cancer B Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2009/04/01 - 2012/06/30 Research trainee (FCT grant) under the project: (FCOMP-01-0124-FEDER-008463, former ref PIC/IC/83154/2007): “Cancer risk and irradiation: an epidemiological and genetic study of a cohort irradiated fo Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projetos

Bolsa

Designação Financiadores
2022/11/01 - 2023/06/30 Fighting Sars-CoV-2 with viral vectors
CENTRO-01-01D2-FEDER000002
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Universidade de Coimbra
Concluído
2018/01 - 2018/12 JPCOFUND/0001/2015
JPCOFUND/0001/2015
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2017/01 - 2017/12/31 UID/NEU/04539/2013 - CNC. IBILI
UID/NEU/04539/2013
Bolseiro de Investigação
CNC.IBILI, Portugal
Concluído
2012/10/01 - 2016/09/30 SFRH / BD / 51965 / 2012
SFRH / BD / 51965 / 2012
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2009/04/01 - 2012/06 FCOMP-01-0124-FEDER-008463, former ref PIC/IC/83154/2007
FCOMP-01-0124-FEDER-008463, former ref PIC/IC/83154/2007
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2023/07/01 - Atual CiNTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
C644865576-00000005
Investigador
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra
Em curso

Outro

Designação Financiadores
2020/02/01 - 2022/10 Calpain inhibition as a therapeutic strategy in Machado-Joseph disease
CPD0020A01
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Blade Therapeutics, Inc.
Concluído
2019/01/01 - 2020/01/31 Calpain inhibition as a therapeutic strategy in Machado-Joseph Disease
CPD0020A01
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Blade Therapeutics, Inc.
Concluído
Produções

Publicações

Artigo em conferência
  1. Ferreira-Marques, M; Cortes, Luisa; Valero, Jorge; Pereira, Dina; Almeida, Luís Pereira de; Cavadas, Cláudia; Aveleira, Célia A. Autor correspondente: Aveleira, Célia A. "Human Progeria fibroblasts in culture to study new strategies to delay aging". Trabalho apresentado em JRC Summer School on Non-Animal Approaches in Science: The Three R...evolution, 2021.
    Publicado
Artigo em revista
  1. Félix, Paulo; Melo, Alexandra A.; Costa, João Panão; Colaço, Mariana; Pereira, Dina; Núñez, Jisette; de Almeida, Luís Pereira; Borges, Olga. "Exploring TLR agonists as adjuvants for COVID-19 oral vaccines". Vaccine 53 (2025): 127078. https://doi.org/10.1016/j.vaccine.2025.127078.
    10.1016/j.vaccine.2025.127078
  2. Arnaut, Zoe A.; Pinto, Sara M. A.; Aroso, Rafael T.; Amorim, Anita S.; Lobo, Catarina S.; Schaberle, Fabio A.; Pereira, Dina; et al. "Selective, broad-spectrum antiviral photodynamic disinfection with dicationic imidazolyl chlorin photosensitizers". Photochemical & Photobiological Sciences 22 11 (2023): 2607-2620. http://dx.doi.org/10.1007/s43630-023-00476-4.
    10.1007/s43630-023-00476-4
  3. Rufino-Ramos, David; Albuquerque, Patrícia R.; Leandro, Kevin; Carmona, Vitor; Martins, Inês M.; Fernandes, Rita; Henriques, Carina; et al. "Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3". Molecular Therapy 31 5 (2023): 1275-1292. http://dx.doi.org/10.1016/j.ymthe.2023.04.001.
    10.1016/j.ymthe.2023.04.001
  4. Santana, Magda M.; Gaspar, Laetitia S.; Pinto, Maria M.; Silva, Patrick; Adão, Diana; Pereira, Dina; Ribeiro, Joana Afonso; et al. "A standardized protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia". Neuropathology and Applied Neurobiology (2023): http://dx.doi.org/10.1111/nan.12892.
    10.1111/nan.12892
  5. Rodrigo F. N. Ribeiro; Dina Pereira; Luis Pereira de Almeida; Maria Manuel C. Silva; Cláudia Cavadas. "SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders". Aging Clinical and Experimental Research (2022): https://doi.org/10.1007/s40520-022-02257-y.
    10.1007/s40520-022-02257-y
  6. Lobo, Catarina S.; Rodrigues-Santos, Paulo; Pereira, Dina; Núñez, Jisette; Trêpa, João C. D.; Sousa, David Lopes; Lourenço, Jorge Vaz; et al. "Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation". Photochemical & Photobiological Sciences (2022): http://dx.doi.org/10.1007/s43630-022-00202-6.
    10.1007/s43630-022-00202-6
  7. Ferreira-Marques, M; Carvalho, A; Franco, Ana Catarina; Leal, A; Botelho, M; Carmo-Silva, Sara; Águas, R; et al. Autor correspondente: Aveleira, Célia A. "Enhancing ghrelin signaling alleviates aging and extends lifespan of a mouse model of human accelerated aging syndrome (under submission).". (2022):
    Submetido
  8. Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Leal, Ana; Carmo-Silva, Sara (9D11-2BDFA256); Botelho, Mariana; Cortes, Luísa; et al. "Enhancing ghrelin alleviates aging and extends lifespan of a mouse model of human accelerated aging syndrome (Under Submission)". (2022):
    Submetido
  9. Ana Vasconcelos-Ferreira; Inês Morgado Martins; Diana Duarte Lobo; Pereira, Dina; Miguel M. Lopes; Rosário Faro; Sara M. Lopes; et al. "ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease". Molecular Therapy (2021):
    Aceite para publicação
  10. Duarte Lobo, Diana; Nobre, Rui Jorge; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís. "The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-00955-0.
    10.1186/s40478-020-00955-0
  11. Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia. "Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells". The Journals of Gerontology: Series A 75 6 (2020): 1073-1078. http://dx.doi.org/10.1093/gerona/glz280.
    10.1093/gerona/glz280
  12. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa Pereira; Barata, Joao; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sonia; et al. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy". European Journal of Clinical Investigation (2019): https://publons.com/publon/28984639/.
  13. Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://dx.doi.org/10.1016/j.ymthe.2018.07.007.
    10.1016/j.ymthe.2018.07.007
  14. Boaventura, Paula; Pereira, Dina; Mendes, Adélia; Teixeira-Gomes, José; Sobrinho-Simões, Manuel; Soares, Paula. "Thyroid and parathyroid tumours in patients submitted to X-ray scalp epilation during the tinea capitis eradication campaign in the North of Portugal (1950–1963)". Virchows Archiv 465 4 (2014): 445-452. http://dx.doi.org/10.1007/s00428-014-1644-0.
    10.1007/s00428-014-1644-0
  15. Boaventura, Paula; Pereira, Dina; Mendes, Adélia; Batista, Rui; da Silva, André Ferreira; Guimarães, Isabel; Honavar, Mrinalini; et al. "Mitochondrial D310 D-Loop instability and histological subtypes in radiation-induced cutaneous basal cell carcinomas". Journal of Dermatological Science 73 1 (2014): 31-39. http://dx.doi.org/10.1016/j.jdermsci.2013.09.002.
  16. Boaventura, Paula; Pereira, Dina; Celestino, Ricardo; Mendes, Adélia; Nakasawa, Tadao; Teixeira-Gomes, José; Sobrinho-Simões, Manuel; Soares, Paula. "Genetic alterations in thyroid tumors from patients irradiated in childhood for tinea capitis treatment". European Journal of Endocrinology 169 5 (2013): 673-679. http://dx.doi.org/10.1530/eje-13-0543.
    10.1530/eje-13-0543
  17. Boaventura, Paula; Oliveira, Rosa; Pereira, Dina; Soares, Paula; Teixeira-Gomes, José. "Head and neck basal cell carcinoma prevalence in individuals submitted to childhood X-ray epilation for tinea capitis treatment". European Journal of Dermatology 22 2 (2012): 225-230. http://dx.doi.org/10.1684/ejd.2012.1670.
    10.1684/ejd.2012.1670
  18. Boaventura, P; Pereira, Dina; Soares, P; Teixeira-Gomes, P. "A campanha da tinha em Portugal – epidemia do passado e possíveis sequelas futuras". Publicação Oncológica Portuguesa Jan-Mar N5 (2012): 22-34.
    Publicado
  19. Boaventura, Paula; Soares, Paula; Pereira, Dina; Teixeira-Gomes, José; Sobrinho-Simões, Manuel. "Head and neck lesions in a cohort irradiated in childhood for tinea capitis treatment". The Lancet Infectious Diseases 11 3 (2011): 163-164. http://dx.doi.org/10.1016/s1473-3099(11)70047-0.
  20. Boaventura, P.; Bastos, J.; Pereira, D.; Soares, P.; Teixeira-Gomes, J.M.. "Alopecia in women submitted to childhood X-ray epilation for tinea capitis treatment". British Journal of Dermatology 163 3 (2010): 643-644. http://dx.doi.org/10.1111/j.1365-2133.2010.09846.x.
  21. de Miranda, Noel FCC; Nielsen, Maartje; Pereira, Dina; van Puijenbroek, Marjo; Vasen, Hans F; Hes, Frederik J; van Wezel, Tom; Morreau, Hans. "MUTYH-associated polyposis carcinomas frequently lose HLA class I expression-a common event amongst DNA-repair-deficient colorectal cancers". The Journal of Pathology 219 1 (2009): 69-76. http://dx.doi.org/10.1002/path.2569.
Capítulo de livro
  1. Boaventura, Paula; Pereira, Dina; Soares, Paula; Teixeira-Gomes, José. "The ringworm campaign in Portugal, 1940–1970". In Ringworm and Irradiation, 181-214. Oxford University Press, 2022.
    10.1093/med/9780197568965.003.0007
  2. Nóbrega, Clévio; Simões, Ana Teresa; Duarte-Neves, Joana; Duarte, Sónia; Vasconcelos-Ferreira, Ana; Cunha-Santos, Janete; Pereira, Dina; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". In Advances in Experimental Medicine and Biology, 349-367. Springer International Publishing, 2018.
    10.1007/978-3-319-71779-1_18
  3. Boaventura, P; Pereira, Dina; Teixeira-Gomes,J; Soares, P. "Radiation Treatment and Alopecia – Past and Present Concerns". 1-22. Nova Science Publishers, 2012.
    Publicado
Poster em conferência
  1. Barros, Inês; Silva, António; Lobo, Diana Duarte; Gonzaga, Daniela; Mele, Miranda; Pereira, Dina; Faro, Rosario; et al. "Mesenchymal Stromal Cell potential to restore autophagy and mitochondria health in Machado-Joseph disease". Trabalho apresentado em 31th Annual Meeting of the European Society of Gene & Cell Therapy, 2024.
  2. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Fernandes, Ana Rita; Lopes, M. M.; Leandro, Kevin; Pereira, Dina; et al. "Intra-cisterna magna administration of allele-specific AAV-based therapy alleviates neuropathology and motor deficits in spinocerebellar ataxia type 3". Trabalho apresentado em ESGCT 31sth Congress, 2024.
  3. Catarina Oliveira Miranda; Perfeito, Rita; Sónia P. Duarte; Paulo, Cristiana; RODRIGUES, MARIANA TEIXEIRA; Gaspar, Laetitia S; Pereira, Dina; et al. "Comparative analysis of transfection kits for linear, self-amplifying, and circular RNA". Trabalho apresentado em ESGCT 31st Annual Congress, 2024.
  4. Gaspar, Laetitia S; Marques, Bruno; Pereira, Dina; De Luca, Pasqualino; Pedro Perdigão; Lopes, Sara; Perfeito, Rita; et al. "Maximizing Yield and Functionality in saRNA Production: A Comparative Study of Commercial Kits and In Vitro Transcription Conditions". Trabalho apresentado em ESGCT 31st Annual Congress, 2024.
  5. De Luca, Pasqualino; Lopes, Sara; Pereira, Dina; Gaspar, Laetitia S; Marques, Bruno; Pedro Perdigão; Melo, Alexandra A.; et al. "Optimizing in vitro transcription methods for enhanced mRNA-based therapeutics". Trabalho apresentado em ESGCT 31st Annual Congress, 2024.
  6. Pereira, Dina; Valdeira, A. S. C.; Santos Silva, Francisca; Gaspar, Laetitia S; De Luca, Pasqualino; Pedro Perdigão; Lopes, Sara; et al. "A comparative analysis of commercial kits for enhanced circular mRNA production: yield, profile, and in vitro assessment". Trabalho apresentado em ESGCT 31st Annual Congress, 2024.
  7. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Fernandes, Ana Rita; Lopes, M. M.; Pereira, Dina; Duarte, S.P.; et al. "Allele-specific silencing of mutant ATXN3 mitigates motor deficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3)". Trabalho apresentado em American Society of Gene Therapy (ASGCT) 27th Annual, 2024.
  8. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Fernandes, Ana Rita; Lopes, Miguel M; Pereira, Dina; Duarte, Sónia P; et al. "Allele-specific silencing for Spinocerebellar Ataxia Type 3 via AAV9 polycistronic microRNA-based therapy". Trabalho apresentado em Annual Meeting of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB day), 2024.
  9. Núñez, Jisette; Pereira, Dina; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Pseudotyped lentiviral particles with the SARS-CoV-2 S protein to study drug repurposing and immunological surveillance". Trabalho apresentado em Pharma PhD Day, 2023.
  10. Lopes, Sara Monteiro; Miguel M. Lopes; Nobre, Rui Jorge; Vasconcelos-Ferreira, Ana; Pereira, Dina; Fernandes, Ana Rita; Barros, Maria Inês; et al. Autor correspondente: Pereira de Almeida, Luis. "Targeting the ATXN3 gene with CRISPR-Cas9 for the therapy of Machado-Joseph disease". Trabalho apresentado em 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  11. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Pereira, Dina; Duarte, Sónia; Lopes, Sara Monteiro; Lopes, Miguel Monteiro; et al. "Investigating routes of administration and AAV serotypes for development of a gene-based therapy for spinocerebellar ataxia type 3 (SCA3)". Trabalho apresentado em ESGCT 30th Congress, 2023.
  12. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Fernandes, Ana Rita; Lopes, Miguel Monteiro; Pereira, Dina; Duarte, Sónia; et al. "Allele-specific silencing of mutant ATXN3 rescues motor deficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3) upon intra-cisterna magna administration". Trabalho apresentado em ESGCT 30th Congress, 2023.
  13. Leandro, Kevin; Rufino-Ramos, David; Lopes, Sara Monteiro; Pasqua, C; Santos P; Silva, Ana Carolina; Lobo, Diana Duarte; et al. "Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Spinocerebellar Ataxia Type 3/Machado-Joseph Disease". Trabalho apresentado em CAG Triplet Repeat Disorders GRC, 2023.
  14. Rufino-Ramos, David; Leandro, Kevin; Vitor, Carmona; Martins, Ines Morgado; Albuquerque, Patrícia Rosado; Fernandes, Ana Rita; Henriques, Carina; et al. "Extracellular Vesicle-Based Delivery of Silencing Sequences for the Treatment of Machado-Joseph Disease". Trabalho apresentado em American Society of Gene Therapy (ASGCT) 26th Annual, 2023.
  15. Ribeiro, Rodrigo; Pereira, Dina; Reis, Tiago; Lopes, Sara; Ferreira-Marques, Marisa; Fernandes, Rita; Gaspar, Laetitia S; et al. "The Circadian Clock is Disrupted in the YAC Machado-Joseph Disease Mouse Model". Trabalho apresentado em BEB Day 2023 - Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) 17th symposium, 2023.
  16. Leandro, Kevin; Rufino-Ramos, David; D'Amelio, T.; Salgueiro, Margarida A.; Lopes, Sara M. ; Pereira, Dina; Martins, M. I.; et al. Autor correspondente: Pereira de Almeida, Luis. "Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Machado-Joseph Disease". Trabalho apresentado em 29th Congress of the European Society for Gene and Cell Therapy (ESGCT) in collaboration with BSGCT; Edinburgh, Scotland, United Kingdom, 2022.
  17. Vasconcelos-Ferreira, Ana; Inês Morgado Martins; Lobo, Diana Duarte; Pereira, Dina; et al.. "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph Disease". Trabalho apresentado em 2019 International Machado-Joseph Research Disease Conference. Washington, DC. USA, 2019.
  18. Silva, P.; Santana, Magda Matos; Cunha, Inês; Ribeiro, Joana; Pereira, Dina; Gaspar, Laetitia; Januário, Cristina; Pereira de Almeida, Luis. "Portuguese-mainland cohort of Machado-Joseph Disease: what can be seen after one-year follow-up?". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  19. Rui Jorge Nobre; Lobo, Diana Duarte; Catarina Oliveira Miranda; Pereira, Dina; Castelhano, Joao; Sereno, José Vitor Oliveira; Castelo-Branco, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Blood-brain barrier dysfunction in spinocerebellar ataxia type 3 (Machado-Joseph disease): Results from mouse and human brain tissues". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  20. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y enhances progerin clearance and delays cellular senescence in human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em 3rd Molecular Biology of Ageing Meeting, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., 2019.
  21. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y ameliorates the aging phenotype of Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em Ageing: models, mechanisms and therapies Conference, Faculty of Medicine, University of Coimbra, Coimbra, Portugal., 2019.
  22. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells ¿ and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  23. Pereira, Dina; Janete Cunha-Santos; Ana Vasconcelos-Ferreira; Joana Duarte-Neves; Isabel Onofre; Vitor Carmona; Claudia Cavadas; Luís Pereira de Almeida. "The role of ageing in polyglutamine induced neurodegeneration. A Study in Machado-Joseph disease models". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, Portugal, 2019.
  24. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), 2018.
  25. Miranda, Catarina O.; Silva, Teresa P.; Marcelo, Adriana; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Trabalho apresentado em 1st international symposium Secretome With]Out[ Borders, 2018.
  26. Pereira, Dina; Janete Cunha-Santos; Joana Duarte-Neves; Ana Vasconcelos-Ferreira; Isabel Onofre; Claudia Cavadas; Luís Pereira de Almeida. "Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models". Trabalho apresentado em 2nd Molecular Biology of Ageing Meeting, Groningen, The Netherlands, 2017.
  27. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Pereira, Dina; Vasconcelos-Ferreira, Ana; Nóbrega, Clévio; et al. "Repeated treatment with Mesenchymal stromal cells sustainably alleviates Machado-Joseph disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017.
  28. Pereira, Dina; Janete Cunha-Santos; Joana Duarte-Neves; Ana Vasconcelos-Ferreira; Isabel Onofre; Claudia Cavadas; Luís Pereira de Almeida. ""Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models". Trabalho apresentado em 1st Symposium on Aging Research @CNC – Molecular Mechanisms of Aging and Age-Related Diseases, Portugal, 2016.
  29. Aveleira, Célia; Botelho, Mariana; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em Cell Symposia ¿ Aging and Metabolism, Sitges, Spain., 2016.
  30. Aveleira, Célia; Cortes, Luísa; Ferreira-Marques, Marisa; Leal, Ana; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Ghrelin enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em 8th Progeria Research Foundation International Scientific Workshop ¿ Across the Table, Around the Globe, Cambridge, MA, USA., 2016.
  31. Pereira, Dina; Janete Cunha-Santos; Joana Duarte-Neves; Ana Vasconcelos-Ferreira; Isabel Onofre; Claudia Cavadas; Luís Pereira de Almeida. "Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models". Trabalho apresentado em XIII CNC Annual Meeting, Portugal, 2015.
  32. Célia A. Aveleira; Luísa Cortes; Jorge Valero; Pereira, Dina; Luís Pereira de Almeida; Claudia Cavadas. "Neuropeptide Y enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford progeria syndrome fibroblasts". Trabalho apresentado em The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, Sunday River, Newry, USA, 2015.
  33. Magda M Santana; Nóbrega, Clévio David Rodrigues ; Nobre, Rui Jorge; Miranda, Catarina; Sousa-Ferreira, Ligia; Simões, Ana Teresa; Duarte, Sónia; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Trabalho apresentado em Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014.
  34. Boaventura, P.; Pereira, D.; Teixeira-Gomes, J.; Soares, P.. "1121 BRAF Mutations in Thyroid Carcinomas Following Childhood Scalp Irradiation". Trabalho apresentado em European Association for Cancer Research (EACR) 22th Meeting, 2012.
  35. Boaventura, Paula; Pereira, Dina; Oliveira, Rosa; Soares, Paula; Sobrinho-Simoes, Manuel; Teixeira-Gomes, José. "Thyroid lesions prevalence in individuals submitted to childhood X-ray epilation for tinea capitis treatment". Trabalho apresentado em 35th Annual Meeting of the European Thyroid Association (ETA 2011) Krakow, 2011.
  36. Boaventura, Paula; Pereira, Dina; Soares, Paula. "Estudo prospectivo e retrospectivo de lesões da cabeça e pescoço numa cohort irradiada na infância para o tratamento da tinea capitis". Trabalho apresentado em II Congresso Nacional de Saúde Pública, Portugal, 2010.
Pré-impressão
  1. Ribeiro, Rodrigo F.N.; Pereira, Dina; Lopes, Sara M.; Reis, Tiago; Silva, Patrick; Lobo, Diana D.; Gaspar, Laetitia S.; et al. "Circadian Rhythms are Disrupted in Patients and Preclinical Models of Machado-Joseph Disease". 2025. https://doi.org/10.1101/2025.01.03.631212.
    10.1101/2025.01.03.631212
  2. Dina Pereira; Janete Cunha-Santos; Ana Vasconcelos-Ferreira; Joana Duarte-Neves; Isabel Onofre; Vítor Carmona; Célia A Aveleira; et al. "Nuclear aging in polyglutamine-induced neurodegeneration". 2023. https://doi.org/10.1101/2023.06.09.544056.
    10.1101/2023.06.09.544056
Resumo em conferência
  1. Salgueiro, Ana Margarida Salgueiro; Ferreira-Marques, Marisa; Lopes, Sara; Pereira, Dina; Ribeiro, Rodrigo; Magda M Santana; Cavadas, Claudia; Pereira de Almeida, Luis. "Investigating Dietary Strategies in Machado-Joseph Disease Models". Trabalho apresentado em BEB Day 2025 - From micro-scales to macro-worlds: transcending the limits of science, Coimbra, 2025.
    Submetido
  2. Arnaut, Zoe A.; Aroso, Rafael T.; Pinto, Sara M. A.; Lobo, Ana Catarina S. ; Amorim, Anita; Calvete, Mário J. F. ; Rodrigues-Santos, Paulo; et al. "Synthesis of di-imidazolyl porphyrins and their chlorin derivatives for photoinactivation of bacteria and viruses". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, 2022.
  3. Lobo, Diana; Nobre, Rui; Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Castelo-Branco, Miguel; De Almeida, Luís. "Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: results from human and mouse samples". 2019.
    10.3389/conf.fncel.2019.01.00022
  4. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease". Trabalho apresentado em XLVIII Reunião Anual da Sociedade de Farmacologia, Lisbon, 2018.
  5. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS". Trabalho apresentado em SPDMov 2018 Meeting ¿ ¿Genética nas Doenças do Movimento¿, 2018.
  6. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, TP; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3, Human Gene Therapy". 2018.
    Publicado
  7. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, TP; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms. . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION". 2018.
    Publicado
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/01 Targeted silencing via AAV9 polycistronic microRNA therapy rescues SCA3 molecular, neuropathological and motor deficits. 54 th Meeting of the Portuguese Society of Pharmacology, 42 nd Meeting of Clinical Pharmacology and 23 rd Meeting of Toxicology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2023/03 Let's make a puzzle: unravelling how Mesenchymal Stromal Cells decrease mutant ataxin-3 levels and promote ameliorations in Machado-Joseph Disease? DCV.talks - Departamento das Ciências e da Vida (DCV)
Departamento das Ciências e da Vida (DCV) (Coimbra, Portugal)
2023/02 Investigating the clock components and circadian activity in the YAC-MJD mouse model. 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2022/12 Mesenchymal Stem Cells for Brain Disorders: the Particular case of Machado-Joseph Disease. Seminar given inside the Gene and Cell Therapy Curricular Unit from the Biomedical Sciences Graduation
Biomedical Sciences Graduation - Algarve University (Portugal)
2022/02 Non-pathogenic viral vectors pseudotyped with the SARS-CoV-2 S protein to study drug repurposing and immunization strategies. 52ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022 Engineered nucleases targeting the ATXN3 gene for the therapy of Machado-Joseph disease. Flash Talk Presentation. 27th European Society for Animal Cell Technology Meeting (ESACT2022)
European Society for Animal Cell Technology (Lisbon, Portugal)
2021/12 Non-pathogenic viral vectors pseudotyped with the SARS-CoV-2 S protein to study drug repurposing and immunization strategies. CIBB Annual Meeting
Centre for Innovative Biomedicine and Biotechnology (CIBB) (Coimbra, Portugal)
2021/06 Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases. 55TH ANNUAL SCIENTIFIC MEETING OF the European Society of Clinical Investigation (ESCI) – Online Event
European Society of Clinical Investigation (ESCI)
2021/02 Importin-8 Silencing Prevents Mutant Ataxin-3 Aggregation And Delays Machado-Joseph Disease Progression. 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2019/12 MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting in Coimbra
Centre for Innovative Biomedicine and Biotechnology (CIBB) (Coimbra, Portugal)
2019/11 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. 2019 International Machado-Joseph Research Disease Conference. Washington, DC. USA
(Washington, DC, Estados Unidos)
2019/11 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. International Research Ataxia Conference (IARC)
(Washington, DC, Estados Unidos)
2019/11 Machado-Joseph Disease: the role of ageing in polyglutamine-induced neurodegeneration. 1st Annual Meeting in Pharmaceutical Sciences
Pharmacy Faculty of UC (Coimbra, Portugal)
2019/05 Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: Results from mouse and human brain tissues. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05 Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/02 Disruption of Blood-Brain Barrier in Machado-Joseph Disease. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia.
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019 Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease. 1st Annual Meeting in Pharmaceutical Sciences
Pharmacy Faculty of UC (Coimbra, Portugal)
2019 DISRUPTION OF BLOOD-BRAIN BARRIER IN MACHADO-JOSEPH DISEASE. XLIX Reunião da Sociedade portuguesa de Farmacologia; XXXVII Reunião de Farmacologia Clínica; XVIII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2018/07 Neuropeptide Y rescues aging phenotype of human Hutchinson-Gilford Progeria syndrome fibroblasts. 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
(Kyoto, Japão)
2018/02 "The role of ageing in polyglutamine-induced neurodegeneration. A Study in Machado-Joseph disease models" XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2018/02 "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease" XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2017/02 "Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models" XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Ghrelin ameliorates the senescent phenotype of human Hutchinson-Gilford progeria syndrome cells. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/01 Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models. BEB DAY - Not So Usual Insights Into a PhD
Center for Neuroscience and Cell Biology (CNC), University of Coimbra (Coimbra, Portugal)
2016 NPY reverts HGPS phenotype. 8th Progeria Research Foundation International Scientific Workshop ¿ Across the Table, Around the Globe, Cambridge, MA, USA.
Progeria Research Foundation (Cambridge, MA, Estados Unidos)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022 - Atual Jisette Nuñez - Título da tese : Drug repurposing, immunological surveillance, and vaccine development for COVID-19 - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2022.12572.BD Orientadores: Luís Pereira de Almeida e Dina Pereira
Coorientador
2020/09/21 - 2021/11/19 Non-pathogenic viral vectors of SARS-CoV-2 to study drug repurposing and immunization strategies
Orientador
 Biotecnologia Farmacêutica (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2014 - 2014 Member of the Organizing Committee for the CNC Annual Meeting, University of Coimbra (2014 - 2014)
Conferência (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2013 Member of the Organizing Committee for the 2nd BEB Symposium (2013 - 2013)
Simpósio (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2007 Member of the Organizing Committee for the Annual Applied Biology Conferences “IX Jornadas de Biologia Aplicada" (2007 - 2007)
Conferência
 Universidade do Minho, Portugal
Distinções

Outra distinção

2011 2ª edição do prémio ACS-Merck Serono – Epidemiologia do Cancro