Ana Luísa Colaço Cardoso (6014-DF87-87A1)

Curriculum Vitae

Ana Luísa Colaço Cardoso

Ana Luísa Cardoso graduated in Biochemistry from the University of Coimbra (UC) in 2004, being awarded a merit prize as one of the top 3% top students of the Faculty for Science and Technology of UC. In the same year, she received a Ph.D. scholarship from the Portuguese Science Foundation (FCT) and initiated her Ph.D. under the supervision of Prof. Dr. Conceição Pedroso de Lima at the Biochemistry Department of UC. Between 2004 and 2008 she worked in the development of lipid-based nanoparticles for siRNA delivery to the CNS, aiming at generating new therapeutic tools for the treatment of acute brain lesions. During her Ph.D. project, she had the opportunity to work with Prof. Ernst Wagner and Dr. Carsten Culmsee, at the Faculty of Pharmacy of Ludwig-Maximillian University (LMU) and with Prof. Dr. Nikolaus PLesnila, at the Institute for Stroke and Dementia Research (LMU) in Munich, between 2006 and 2007. After obtaining her Ph.D. in Biochemical Technology (2008), Ana Cardoso integrated the Center for Neuroscience and Cell Biology (CNC) as a Post Doc, where she investigated the role of miRNA deregulation in CNS diseases, including glioblastoma and Alzheimer's disease (AD). In 2012, Ana Cardoso was awarded a grant from FCT to develop a new lentiviral-based platform to modulate miRNAs in AD animal models, aiming at decreasing APP and BACE levels and improving neuronal deficits. As a result of her efforts, in 2013, she was selected to integrate the project New Strategies to Manage Brain Diseases, assuming a two-year position as an Invited Auxiliary Investigator at UC. From 2013 to 2015 Ana Cardoso took her first steps as an independent scientist, focusing her research in the field of neuroimmunology, and publishing her first papers as the corresponding author. In 2016 she was awarded a second Pos Doc fellowship to continue to investigate the contribution of miRNAs to the modulation of innate immune responses. During her career, Ana Cardoso has worked with several national and international Ph.D. and Master Programs, successfully supervising 12 Master students and 4 Ph.D. students and organizing/participating in several Advanced Courses in Neurosciences, Gene Therapy, and Epigenetics, both at CNC and in other Portuguese Institutions. In 2017, Ana Cardoso accepted a new professional challenge and integrated, as a Senior Investigator, the recently formed Neuronal Circuits and Behavior Group, led by Dr. João Peça. Her most recent work has been focused on understanding the crosstalk between the immune system and neuronal homeostasis mechanisms, with the ultimate goal of unveiling the role of stress-triggered neuroinflammatory events in synaptic architecture and the development of neuropsychiatric and neurodegenerative disorders. Since 2005 Ana Luísa Cardoso has published 46 peer-reviewed papers and 7 book chapters (over 2500 citations; h-index of 27), 9 as the last/corresponding author. In the last 5 years, she has attained competitive funding as a Principal Investigator from both national and international agencies (FCT, Bial Foundation, Takeda).

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Identificação

Identificação pessoal

Nome completo: Ana Luísa Colaço Cardoso

Nomes de citação

Cardoso, Ana

Identificadores de autor

Ciência ID: 6014-DF87-87A1
ORCID iD: 0000-0001-5145-4561

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
Ciências Médicas e da Saúde - Medicina Básica - Imunologia
Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Alemão	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)
Francês	Utilizador elementar (A1)	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador elementar (A1)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)

Formação

	Grau	Classificação
2010/04 - 2010/06 Concluído	Curso de Formação Inicial de Formadores (Curso de Especialização Tecnológica) Instituto do Emprego e Formação Profissional, Portugal
2009/09/08 - 2009/09/19 Concluído	Course in Laboratorial Animal Science (Pós-Graduação) Direcção-Geral de Alimentação e Veterinária, Portugal
2008/07/10 Concluído	Bioquímica (Doutoramento) Especialização em Especialidade: Tecnologia Bioquímica Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Gene Silencing as a Promising Strategy for Neuroprotection: on the Development of a Lipid-based System for the Delivery of Sirnas to the Central Nervous System" (TESE/DISSERTAÇÃO)	Aprovado com Louvor e Distinção por Unanimidade
2008/02 - 2008/05 Concluído	Technologic Entrepreneurship Course (Pós-Graduação) Universidade de Coimbra, Portugal
2004/06/30 Concluído	Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Tf-lipoplex-mediated NGF gene transfer to the CNS: neuroprotection and recovery in an excitotoxic model of brain injury" (TESE/DISSERTAÇÃO)	16

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2019/01/01 - Atual	Investigador (Investigação)	CNC.IBILI, Portugal
	CNC.IBILI, Portugal
2016/01/01 - 2019/01/14	Pós-doutorado (Investigação)	CNC.IBILI, Portugal

2013/11/01 - 2015/06/30	Investigador Auxiliar Convidado (carreira) (Investigação)	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

2009/01/01 - 2013/09/10	Pós-doutorado (Investigação)	CNC.IBILI, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2006/09/01 - 2007/07/31	Visiting Scholar	Ludwig-Maximilians-Universitat Munchen, Alemanha
	Ludwig-Maximilians-Universitat Munchen, Alemanha
2003/09/01 - 2004/07/31	Internship at the Center for Neuroscience and Cell Biology (Vectors and Gene Therapy Group)	CNC.IBILI, Portugal

Projetos

Projeto

	Designação	Financiadores
2023/03/01 - Atual	Th2brain: Effects of Th2-related immunity in the postnatal maturation of brain circuits 2022.02604.PTDC Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2019/01/15 - 2025/01/14	Unraveling miRNA contribution to neuroinflammation and dementia DL 57/2016/CP1448/CT0023 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/02/01 - 2024/01/31	Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies PTDC/MED-NEU/5993/2020 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2023/12/31	Disease modelling of frontotemporal dementia in human brain organoids PTDC/MEC-NEU/4814/2020 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2023/04/30	Evaluation of TETO-OSKM lentiviral constructs in Dementia models CSD1010A01#IV1010 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	YouthBio Therapeutics Em curso
2022/03/01 - 2023/03/31	BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids EXPL/MED-OUT/1470/2021 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/03/01 - 2022/12/31	Does healthy microglia rescue neuroinflammation and synaptic dysfunction in human cerebral organoids with FTD-associated mutations? EN119 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Takeda Pharmaceuticals Asia Pacific Pte Ltd Em curso
2018/07/26 - 2021/07/25	The neuroinflammatory reaction to acute systemic inflammation during delirium and its impact in the cognitive trajectory and progression to dementia: a case-control longitudinal study using imaging and molecular biomarkers PTDC/MEC-PSQ/32501/2017 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2016/04/01 - 2019/10/01	Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation PTDC/NEU-SCC/3247/2014 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/01/01 - 2019/01/14	Understanding the contribution of miRNAs to neuroinflammation in Alzheimer´s disease SFRH/BPD/108312/2015 Bolseiro de Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03/01 - 2015/08/31	Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease PTDC/BIM-MEC/0651/2012 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03/02 - 2015/06/01	Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery PTDC/DTP-FTO/0265/2012 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03 - 2015/03	Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery Provided by PTCRIS: 124488 124488	Fundação para a Ciência e a Tecnologia, I.P.
2013/01/01 - 2014/12/31	PROJECTO ESTRATÉGICO - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013 PEst-C/SAU/LA0001/2013 Investigador CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009/01/01 - 2013/10/31	INFLAMMATORY MECHANISMS IN NEURODEGENERATION: MIRNAS AS REGULATORS OF THE IMMUNE SYSTEM RESPONSE IN ALZHEIMERS DISEASE SFRH/BPD/46228/2008 Bolseiro de Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/05/01 - 2010/12/31	Development of novel approaches for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic nucleic acids and proteins PTDC/BIO/65627/2006 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/01/01 - 2008/12/31	SILENCIAMENTO DE GENES PRÓ-APOPTÓTICOS PARA O TRATAMENTO DA LESÃO CEREBRAL: DESENVOLV. DE VECTORES DE BASE LIPÍDICA PARA POTENCIAR A ENTREGA DE SIRNA E DE GENES CODIFICADORES DE SIRNA NUM MODELO NEURONAL DE ISQUÉMIA SFRH/BD/17216/2004 Bolseiro de Doutoramento Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em conferência	Sequeira, Diana; Cardoso, Ana; Peça, João; Palma, Paulo; Santos, João Miguel. "The effect of calcium silicate-based cements on viability of stem cells within the apical papilla". Trabalho apresentado em 17° Biennal Congress of the European Society of Endodontology, Barcelona, 2015.
Artigo em revista	Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Pinto, Maria J.; Reis, Tiago; Cardoso, Ana Maria; et al. "IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development". Neuron 111 21 (2023): 3435-3449.e8. http://dx.doi.org/10.1016/j.neuron.2023.09.031. 10.1016/j.neuron.2023.09.031 Martins, Mariana; Oliveira, Ana Rafaela; Martins, Solange; Vieira, José Pedro; Perdigão, Pedro; Fernandes, Ana Rita; de Almeida, Luís Pereira; et al. "A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia". International Journal of Molecular Sciences 24 16 (2023): 12603. http://dx.doi.org/10.3390/ijms241612603. Publicado • 10.3390/ijms241612603 Oliveira, Fernanda Bellaniza Caminha de; Freire, Vanessa Paola Alves Sampaio de Sá; Coelho, Sharton Vinicius Antunes; Meuren, Lana Monteiro; Palmeira, Julys da Fonseca; Cardoso, Ana Luísa; Neves, Francisco de Assis Rocha; et al. "ZIKV Strains Elicit Different Inflammatory and Anti-Viral Responses in Microglia Cells". Viruses 15 6 (2023): 1250. http://dx.doi.org/10.3390/v15061250. Publicado • 10.3390/v15061250 Regueira, Patrícia; Silva, Ana Rita; Cardoso, Ana Luísa; Cardoso, Ana Maria; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim. "Peripheral inflammatory markers during an acute bacterial infection in older patients with and without cognitive dysfunction: A case control study". Brain, Behavior, & Immunity - Health 25 (2022): 100503. http://dx.doi.org/10.1016/j.bbih.2022.100503. Publicado • 10.1016/j.bbih.2022.100503 Silva, Ana Rita; Regueira, Patricia; Peres, André; Cardoso, Ana Luísa; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim. "In vivo molecular imaging of the neuroinflammatory response to peripheral acute bacterial infection in older patients with cognitive dysfunction: A cross-sectional controlled study". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.984178. Publicado • 10.3389/fnagi.2022.984178 Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica M.; Cardoso, Ana L.; Peça, João. "Microglia-dependent remodeling of neuronal circuits". Journal of Neurochemistry 163 2 (2022): 74-93. http://dx.doi.org/10.1111/jnc.15689. Publicado • 10.1111/jnc.15689 Oliveira, Ana Rafaela; Martins, Solange; Cammarata, Giuseppe; Martins, Mariana; Cardoso, Ana Maria; Almeida, Maria Rosário; do Carmo Macário, Maria; et al. "Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations". Biomedicines 10 8 (2022): 1905. http://dx.doi.org/10.3390/biomedicines10081905. Publicado • 10.3390/biomedicines10081905 Costa Silva, Ana Rita; Regueira, Patrícia; Cardoso, Ana; Baldeiras, Ines; Santana, Isabel; Cerejeira, Joaquim. "Cognitive trajectories following acute infection in older patients with and without cognitive impairment: an one-year follow-up study". Frontiers in Psychiatry (2022): No prelo Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512-111512. https://doi.org/10.1016/j.mad.2021.111512. 10.1016/j.mad.2021.111512 Sequeira, Diana; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo; Peça, João; Cardoso, Ana; Santos, João Miguel. "Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials". Clinical Oral Investigations (2021): Aceite para publicação Silva, Ana Rita; Regueira, Patrícia; Albuquerque, Elisabete; Baldeiras, Inês; Cardoso, Ana Luísa; Santana, Isabel; Cerejeira, Joaquim. "Estimates of Geriatric Delirium Frequency in Noncardiac Surgeries and Its Evaluation Across the Years: A Systematic Review and Meta-analysis". Journal of the American Medical Directors Association (2020): http://dx.doi.org/10.1016/j.jamda.2020.08.017. Publicado • 10.1016/j.jamda.2020.08.017 Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Cardoso, Ana L.; Peça, João. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". Neuropsychopharmacology 45 9 (2020): 1438-1447. http://dx.doi.org/10.1038/s41386-020-0727-7. Publicado • 10.1038/s41386-020-0727-7 Barros-Viegas, Ana Teresa; Guedes, Joana; Cardoso, Ana Maria; Pereira de Almeida, Luís; Resende de Oliveira, Catarina; Pedro de Magalhães, João; Peça, João; Cardoso, Ana Luísa. "miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease". Molecular Therapy - Nucleic Acids 19 (2020): 1219-1236. http://dx.doi.org/10.1016/j.omtn.2020.01.010. Publicado • 10.1016/j.omtn.2020.01.010 Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Cardoso, Ana Luísa; Peça, João. "Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-09382-9. 10.1038/s41467-019-09382-9 Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João. "Effects of a New Bioceramic Material on Human Apical Papilla Cells". Journal of Functional Biomaterials 9 4 (2018): 74. http://dx.doi.org/10.3390/jfb9040074. 10.3390/jfb9040074 Cardoso, Ana Luisa; Fernandes, Adelaide; Aguilar-Pimentel, Juan Antonio; de Angelis, Martin Hrabe; Guedes, Joana Ribeiro; Brito, Maria Alexandra; Ortolano, Saida; et al. "Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases". Ageing Research Reviews 47 (2018): 214-277. http://dx.doi.org/10.1016/j.arr.2018.07.004 IF=8.973. 10.1016/j.arr.2018.07.004 Guedes, Joana R.; Lao, Taotao; Cardoso, Ana L.; El Khoury, Joseph. "Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-ß and Tau Pathologies". Frontiers in Neurology 9 (2018): http://dx.doi.org/10.3389/fneur.2018.00549 IF=3.508. 10.3389/fneur.2018.00549 Cabral Filho, P.E.; Cabrera, M.P.; Cardoso, A.L.C.; Santana, O.A.; Geraldes, C.F.G.C.; Santos, B.S.; Pedroso de Lima, M.C.; Pereira, G.A.L.; Fontes, A.. "Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells". Biochimica et Biophysica Acta - General Subjects 1862 12 (2018): 2788-2796. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052949793&partnerID=MN8TOARS. 10.1016/j.bbagen.2018.08.014 Cunha, P.P.; Costa, P.M.; Morais, C.M.; Lopes, I.R.; Cardoso, A.M.; Cardoso, A.L.; Mano, M.; Jurado, A.S.; Pedroso De Lima, M.C.P.. "High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors". Human Molecular Genetics 26 22 (2017): 4375-4387. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034256071&partnerID=MN8TOARS. 10.1093/hmg/ddx323 Viegas, A.T.B.; Guedes, J.R.; Oliveira, A.R.; Cardoso, A.M.S.; Cardoso, A.L.C.. "miRNAs: New biomarkers and therapeutic targets in dementia". Current Pharmaceutical Design 23 5 (2017): 669-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017530528&partnerID=MN8TOARS. 10.2174/1381612823666170111094702 von Zglinicki, Thomas; Varela-Nieto, Isabel; Brites, Dora; Karagianni, Niki; Ortolano, Saida; Georgopoulos, Spiros; Cardoso, Ana Luisa; et al. "Frailty in mouse ageing: A conceptual approach". Mechanisms of Ageing and Development 160 (2016): 34-40. http://dx.doi.org/10.1016/j.mad.2016.07.004 IF=3.087. 10.1016/j.mad.2016.07.004 Cardoso, Ana L; Guedes, Joana R; de Lima, Maria C Pedroso. "Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions". Current Opinion in Pharmacology 26 (2016): 1-9. http://dx.doi.org/10.1016/j.coph.2015.09.001 IF=5.563. 10.1016/j.coph.2015.09.001 Guedes, Joana R.; Santana, Isabel; Cunha, Catarina; Duro, Diana; Almeida, Maria R.; Cardoso, Ana M.; de Lima, Maria C. Pedroso; Cardoso, Ana L.. "MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease". Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 3 (2016): 7-17. http://dx.doi.org/10.1016/j.dadm.2015.11.004. 10.1016/j.dadm.2015.11.004 Cabral Filho, P.E.; Cardoso, A.L.C.; Pereira, M.I.A.; Ramos, A.P.M.; Hallwas, F.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; et al. "CdTe quantum dots as fluorescent probes to study transferrin receptors in glioblastoma cells". Biochimica et Biophysica Acta - General Subjects 1860 1 (2016): 28-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946430431&partnerID=MN8TOARS. 10.1016/j.bbagen.2015.09.021 Costa, Pedro; Cardoso, Ana; Mano, Miguel; Lima, Maria. "MicroRNAs in Glioblastoma: Role in Pathogenesis and Opportunities for Targeted Therapies". CNS & Neurological Disorders - Drug Targets 14 2 (2015): 222-238. http://dx.doi.org/10.2174/1871527314666150116123610 IF=2.188. 10.2174/1871527314666150116123610 Costa, P.M.; Cardoso, A.L.; Mano, M.; de Lima, M.C.P.. "MicroRNAs in glioblastoma: Role in pathogenesis and opportunities for targeted therapies". CNS and Neurological Disorders - Drug Targets 14 2 (2015): 222-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930907378&partnerID=MN8TOARS. Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression". Molecular Pharmaceutics 12 3 (2015): 716-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924023696&partnerID=MN8TOARS. 10.1021/mp5005349 Costa, P.M.; Cardoso, A.L.; Custódia, C.; Cunha, P.; Pereira De Almeida, L.; Pedroso De Lima, M.C.. "MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma". Journal of Controlled Release 207 (2015): 31-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926665383&partnerID=MN8TOARS. 10.1016/j.jconrel.2015.04.002 Guedes, J.R.; Custódia, C.M.; Silva, R.J.; de Almeida, L.P.; de Lima, M.C.P.; Cardoso, A.L.. "Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model". Human Molecular Genetics 23 23 (2014): 6286-6301. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926341070&partnerID=MN8TOARS. 10.1093/hmg/ddu348 Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.; Cruz, R.; Zhu, K.; Pedroso De Lima, M.C.; Jurado, A.S.; Nyström, B.. "Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery". Molecular Pharmaceutics 11 3 (2014): 819-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901742907&partnerID=MN8TOARS. 10.1021/mp400510a Calejo, Maria Teresa; Cardoso, Ana Maria S.; Kjøniksen, Anna-Lena; Zhu, Kaizheng; Morais, Catarina M.; Sande, Sverre Arne; Cardoso, Ana Luísa; et al. "Temperature-responsive cationic block copolymers as nanocarriers for gene delivery". International Journal of Pharmaceutics 448 1 (2013): 105-114. http://dx.doi.org/10.1016/j.ijpharm.2013.03.028 IF=3.785. 10.1016/j.ijpharm.2013.03.028 Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Simões, Sérgio; et al. "Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment". Molecular Therapy - Nucleic Acids 2 (2013): e100. http://dx.doi.org/10.1038/mtna.2013.30 IF=6.425. 10.1038/mtna.2013.30 Guedes, J.; Cardoso, A. L. C.; Pedroso de Lima, M. C.. "Involvement of MicroRNA in Microglia-Mediated Immune Response". Clinical and Developmental Immunology 2013 (2013): 1-11. http://dx.doi.org/10.1155/2013/186872 IF=2.934. 10.1155/2013/186872 Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de Lima, M.C.. "Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications". Current Pharmaceutical Design 19 16 (2013): 2895-2923. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878655380&partnerID=MN8TOARS. 10.2174/1381612811319160006 Costa, P.M.; Cardoso, A.L.; Nóbrega, C.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de Lima, M.C.. "MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma". Human Molecular Genetics 22 5 (2013): 904-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873438180&partnerID=MN8TOARS. 10.1093/hmg/dds496 Cardoso, A.M.; Trabulo, S.; Cardoso, A.L.; Maia, S.; Gomes, P.; Jurado, A.S.; Pedroso De Lima, M.C.. "Comparison of the efficiency of complexes based on S413-PV cell-penetrating peptides in plasmid DNA and siRNA delivery". Molecular Pharmaceutics 10 7 (2013): 2653-2666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879735661&partnerID=MN8TOARS. 10.1021/mp400078h Cardoso, Ana M.S.; Trabulo, Sara; Cardoso, Ana L.; Lorents, Annely; Morais, Catarina M.; Gomes, Paula; Nunes, Cláudia; et al. "S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization". Biochimica et Biophysica Acta (BBA) - Biomembranes 1818 3 (2012): 877-888. http://dx.doi.org/10.1016/j.bbamem.2011.12.022 IF=3.389. 10.1016/j.bbamem.2011.12.022 Costa, P.M.; Cardoso, A.L.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de lima, M.C.. "PDGF-B-mediated downregulation of miR-21: New insights into PDGF signaling in glioblastoma". Human Molecular Genetics 21 23 (2012): 5118-5130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869025536&partnerID=MN8TOARS. 10.1093/hmg/dds358 Cardoso, Ana L.; Guedes, Joana R.; Pereira de Almeida, Luís; Pedroso de Lima, Maria C.. "miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production". Immunology 135 1 (2011): 73-88. http://dx.doi.org/10.1111/j.1365-2567.2011.03514.x IF=3.705. 10.1111/j.1365-2567.2011.03514.x Trabulo, S.; Cardoso, A.M.; Santos-Ferreira, T.; Cardoso, A.L.; Simões, S.; Pedroso De Lima, M.C.. "Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents". Molecular Pharmaceutics 8 4 (2011): 1120-1131. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961082146&partnerID=MN8TOARS. 10.1021/mp100426e Trabulo, Sara; Cardoso, Ana Luísa; Mano, Miguel; De Lima, Maria C. Pedroso. "Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems". Pharmaceuticals 3 4 (2010): 961-993. http://dx.doi.org/10.3390/ph3040961. 10.3390/ph3040961 Cardoso, A.L.C.; Costa, P.; de Almeida, L.P.; Simões, S.; Plesnila, N.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C.. "Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo". Journal of Controlled Release 142 3 (2010): 392-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349098528&partnerID=MN8TOARS. 10.1016/j.jconrel.2009.11.004 Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Plesnila, N.; Pedroso de Lima, M.C.; Wagner, E.; Culmsee, C.. "Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS". Journal of Controlled Release 132 2 (2008): 113-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-56349102126&partnerID=MN8TOARS. 10.1016/j.jconrel.2008.08.014 Trabulo, S.; Mano, M.; Faneca, H.; Cardoso, A.L.; Duarte, S.; Henriques, A.; Paiva, A.; et al. "S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA". Journal of Gene Medicine 10 11 (2008): 1210-1222. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149190435&partnerID=MN8TOARS. 10.1002/jgm.1247 Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C.. "siRNA delivery by a transferrin-associated lipid-based vector: A non-viral strategy to mediate gene silencing". Journal of Gene Medicine 9 3 (2007): 170-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047102911&partnerID=MN8TOARS. 10.1002/jgm.1006 P. de Lima, M.; Girao da Cruz, M.; C. Cardoso, A.; Simoes, S.; de Almeida, L.. "Liposomal and Viral Vectors for Gene Therapy of the Central Nervous System". Current Drug Target -CNS & Neurological Disorders 4 4 (2005): 453-465. http://dx.doi.org/10.2174/1568007054546144 IF=3.236. 10.2174/1568007054546144 Teresa Girão da Cruz, M; Cardoso, A L C; de Almeida, L P; Simões, S; Pedroso de Lima, M C. "Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury". Gene Therapy 12 16 (2005): 1242-1252. http://dx.doi.org/10.1038/sj.gt.3302516 IF=5.18. 10.1038/sj.gt.3302516
Capítulo de livro	Cardoso, Ana L.; Guedes, Joana R.. "Quantifying miRNA Deregulation in Alzheimer’s Disease". In Biomarkers for Alzheimer’s Disease Drug Development, 307-319. Springer New York, 2018. 10.1007/978-1-4939-7704-8_21 Cardoso, Ana M.; Cardoso, Ana L.; Pedroso de Lima, Maria C.; Jurado, Amalia S.. "Nonviral Therapeutic Approaches for Modulation of Gene Expression: Nanotechnological Strategies to Overcome Biological Challenges". In Nanoparticles in Life Sciences and Biomedicine, 409-440. Pan Stanford, 2018. 10.1201/9781351207355-14 Cardoso, A.M.; Guedes, J.R.; Cardoso, A.L.; Morais, C.; Cunha, P.; Viegas, A.T.; Costa, R.; Jurado, A.; Pedroso de Lima, M.C.. "Recent Trends in Nanotechnology Toward CNS Diseases: Lipid-Based Nanoparticles and Exosomes for Targeted Therapeutic Delivery". In Gene Therapy. 2016. 10.1016/bs.irn.2016.05.002 Guedes, J.; Viegas, A.T.; Pedroso de Lima, M.C.; Cardoso, A.L.. "Microglia: A double-edged sword for Alzheimer's disease". In Gene Therapy. 2015. Cardoso, Ana. "Interaction of nucleic acids with biological membranes: activation of inflammatory mechanisms". In A Toxicological / Pharmacological Approach to the Chemico-Biological Interactions at the Membrane Level, editado por Jurado A.S.. Translational Research Network, 2013. Publicado Faneca, Henrique; Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; de Lima, Maria C. Pedroso. "Cationic Liposome-Based Systems for Nucleic Acid Delivery: From the Formulation Development to Therapeutic Applications". In Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 153-184. Springer Netherlands, 2013. 10.1007/978-94-007-6010-3_6 Cardoso, A.L.; Trabulo, S.M.; Duarte, S.P.; Costa, P.M.; Almeida, L.P.; de Lima, M.C.P.. "Gene silencing as a promising strategy to target CNS and neurological disorders". In Gene Therapy. 2009.
Livro	Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Düzgünes, N.; Jurado, A.S.; De Lima, M.C.P.. Cell-penetrating peptide-based systems for nucleic acid delivery: A biological and biophysical approach. 2012. 10.1016/B978-0-12-391858-1.00014-9 Cardoso, A.; Trabulo, S.; Moreira, J.N.; Düzgünes, N.; de Lima, M.C.P.. Chapter 14 Targeted Lipoplexes for siRNA Delivery. 2009. 10.1016/S0076-6879(09)65014-X
Poster em conferência	Neves, Mafalda; Martins, Solange; Cardoso, Ana. Autor correspondente: Cardoso, Ana. "Generation and characterization of induced pluripotent stem cells derived from human dermal fibroblast lines". Trabalho apresentado em FENS Regional Meeting, 2023. Martins, Solange; Neves, Mafalda; Cardoso, Ana. Autor correspondente: Cardoso, Ana. "Immunocompetent brain organoids to study the pathological mechanisms of Frontotemporal Dementia". Trabalho apresentado em FENS Regional Meeting, 2023. Cardoso, Ana. "Postnatal L-4 administration induces long-term dysfunction in cerebellar-VTA connectivity". Trabalho apresentado em 9th FENS Forum, 2022. Cardoso, Ana. "Exploring the missing link between neuronal primary cilia dysfunction and neurodevelopmental disorders - hints from dental stem cell-derived brain organoids". Trabalho apresentado em 9th FENS Forum, 2022. Cardoso, Ana. "Allergies and IL-4 shape postnatal cerebellar development via microglia-mediated neuronal pruning to induce ADHD-like behaviors in mice". Trabalho apresentado em 9th FENS Forum, 2022. Cardoso, Ana. "Exposure to early-life stress promotes sex-dependent changes in microglia morphology and phagocytic activity in the prefrontal cortex". Trabalho apresentado em 9th FENS Forum, 2022. Cardoso, Ana. "Early-life adversity induces sex-specific dysfunction of the mOFC and leads to impulsive, hyperactive, and risk-taking behaviours in juvenile male mice". Trabalho apresentado em 9th FENS Forum, 2022. Costa, Jéssica; Cardoso, Ana. "The influence of maternal bonding in neuroimmune synaptic function". Trabalho apresentado em 13º Symposium of Bial Foudation ¿ Behind and Beyond the Brain; The mystery of time, 2022. Cardoso, Ana. "Early life stress and social hierarchies: The role of cortico-striatal circuits". Trabalho apresentado em 13th Symposium of Bial Foundation, 2022. Cardoso, Ana. "The influence of maternal bonding in neuroimmune synaptic function”,". Trabalho apresentado em 13th Symposium of Bial Foundation,, 2022. Cardoso, Ana; Guedes, Joana; Ferreira, António Pedro A.; João Miguel Peça. "Abnormal microgia-mediated prunning in the cerebellum induces circuitry and behavioral disfunction in mice". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Cardoso, Ana; Mariana, Laranjo; Peça, João. "Dissecting the role of parvalbumin-positive inhibitory neurons in the cellular and behavioural phenotypes associated with Gprasp2 deletion". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Gomes, Marcos; Pereira, Marta; Laranjo, Mariana; Reis, Tiago; Cardoso, Ana Maria; Ferreira-Marques, Marisa; Aveleira, Célia; et al. "GPRASP2 (dys)function in metabolism and obesity". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Regueira, Patrícia; Silva, Ana Rita; Cardoso, Ana; Santana, Isabel; Cerejeira, Joaquim. "Unravelling the effect of peripheral inflammatory markers as a predictor of cognitive decline in delirious patients". Trabalho apresentado em 20th WPA WORLD CONGRESS OF PSYCHIATRY, 2021. Cardoso, Ana; Costa, Jéssica; Martins, Solange; Ferreira, P.A.; Guedes, J. R.; Carvalho, MJ; Peça, João. "Early-life stress causes sex-dependent changes in microglia function, circuit wiring and behavior in the mPFC". Trabalho apresentado em 12th FENS Forum of Neuroscience, Glasgow, Scotland, 2020. Seabra, Catarina; Oliveira, Ana Rafaela; Guedes, J.; Cardoso, AL; Sequeira, D; Palma, P; Santos, JM; Oliveira, G; Peça, JM. "Modelling the Neurogenetics of Neurodevelopmental Disorders - Hints from organoids". Trabalho apresentado em Meeting of the Portuguese Society of Human Genetics, 2019. Costa, Jéssica; Ferreira, António Pedro de Azevedo; Guedes, Joana R.; Franco, Lara; Peça, João M.; Cardoso, Ana. "Early-life stress causes behaviour changes and microglia dysfunction in the pre-frontal cortex of male mice". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, 2019. Guedes, J; Ferreira, António Pedro A.; Costa, J; Pereira, Marta; Cardoso, AL; Peça, J. "IL-4 skews the microglial developmental program during cerebellar maturation". Trabalho apresentado em Portuguese Society for Neuroscience, 2019. Seabra, Catarina; Oliveira, Ana R.; Guedes, Joana R.; Sequeira, Diana; Palma, Paulo J.; Santos, João Miguel; Duque, Frederico; et al. "Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders". Trabalho apresentado em Meeting of the Portuguese Society for Neuroscience, 2019. Guedes, Joana R.; Ferreira, António Pedro A.; Costa, Jéssica; Pereira, Marta; Cardoso, Ana; Peça, João M.. "Microglia-dependent remodelling of cerebellar circuits". Trabalho apresentado em Gordon Research Conference on Neuroimmune Communication in Health and Disease, 2019. 10.1109/ipcc.1993.593861 Costa, Jéssica; Guedes, J. R.; Ferreira, P.A.; Franco, Lara Oliveira; Peça, João; Cardoso, Ana. "Early-life stress causes behavior changes and microglia dysfunction in the pre-frontal cortex of male mice". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, 2019. Guedes, J. R.; Ferreira, P.A.; Costa, Jéssica; Pereira, Marta; Cardoso, Ana; Peça, João. "Microglia-dependent remodeling of cerebellar circuits". Trabalho apresentado em Gordon Research Conference - Neuroimmune Communication in Health and Disease, Exploring Neuroimmunology: From Single Cells to Organisms, 2019. Franco L., Edfawy L., Pereira M., Laranjo M.,; Cardoso, Ana; Peça, João M.. "Golgi-like labelling and sparse tagging of neurons using peripheral administration of AAVs". Trabalho apresentado em 52º International Congress on Microscopy and Microanalysis, 2018. A.T. Viegas, V. Carmona, J. Guedes, A.R. Oliveira, L. Pereira de Almeida, C. Resende Oliveira, J.P. de Magalhães, J. P; Cardoso, Ana. "MicroRNA modulation: a promising therapeutic strategy for Alzheimer’s disease". Trabalho apresentado em 4th International Conference on Molecular Neurodegeneration (ICMN 2016): Novel Systems and Emerging Concepts, 2016. Cardoso, Ana. "Using miRNA modulation to target amyloid-ß cascade in Alzheimer’s disease". Trabalho apresentado em Biology of Ageing Conference, 2015. Cardoso, Ana. "MicroRNA modulation as a new therapeutic strategy for Alzheimer’s disease". Trabalho apresentado em XIV Meeting of Portuguese Society for Neurosciences, 2015. Cardoso, Ana. "Dissecting the role of microRNAs and their therapeutical potential in Alzheimer’s disease". Trabalho apresentado em 40th Congress of the Federation of the European Biochemical (FEBS) – The Biochemical Basis of Life, 2015. Cardoso, Ana. "MicroRNA modulation renders glioblastoma cells sensitive to chemotherapy". Trabalho apresentado em European Journal of Clinical Investigation (ESCI) 2015 Annual Scientific Meeting, 2015. Cardoso, Ana. "A promising targeted strategy to overcome drug-resistance in glioblastoma". Trabalho apresentado em EMBO workshop: Modern DNA concepts and tools for safe transfer and modification, 2015. Cardoso, Ana. "Dissecting the role of microRNAs and their therapeutic potential in Alzheimer’s disease". Trabalho apresentado em 12th International Conference on Alzheimer's and Parkinson's Diseases, 2015. Cardoso, Ana. "miR-21 and miR-128 modulation sensitizes glioblastoma cells to sunitinib treatment". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014. Cardoso, Ana. "Vectorized oligonucleotide delivery renders glioblastoma cells sensitive to chemotherapy". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014. Cardoso, Ana. "Molecular and phenotypic immune-related alterations in monocytes and monocyte-derived macrophages of Alzheimer’s disease Patients". Trabalho apresentado em 9th FENS Forum, 2014. Cardoso, Ana. "Molecular and phenotypic alterations in the mononuclear phagocyte system of Alzheimer’s disease patients". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014. Cardoso, Ana. "Upregulation of c-Jun in the 3xTrg AD model regulates miR-155 expression in glial cells and contributes to neuroinflammation". Trabalho apresentado em European Meeting on Glial Cells in Health and Disease, 2013. Cardoso, Ana. "Silencing of miR-21 in microglia affects its immune response and enhances glioma cell death". Trabalho apresentado em EMBO's Young Scientist's Forum, 2013. Cardoso, Ana. "MiR-155 silencing decreases neuroinflammation in activated microglia and astrocytes". Trabalho apresentado em EMBO's Young Scientists Forum, 2013. Cardoso, Ana. "Deregulation of immune-related miRNAs in Alzheimer’s disease". Trabalho apresentado em 10th European meeting of glial cells in health and disease, 2011.
Tese / Dissertação	Cardoso, Ana. "Gene silencing as a promising strategy for neuroprotection : on the development of a lipid-based system for the delivery of siRNAs to he central nervous system". Doutoramento, Universidade de Coimbra, 2008. http://hdl.handle.net/10316/7447.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/05/03	Impact of early-life stress in neuroimmune interactions in the pre-frontal cortex: a tale of two sexes	7th Symposium of the Portuguese Glial Network Glial Network (Albufeira, Portugal)
2022/12/07	How early-life adversity impacts neuronal connectivity and shapes circuit wiring in the pre-frontal cortex	DCV Talks DCV (Coimbra, Portugal)
2022/04/04	The influence of maternal bonding in neuroimmune synaptic sculpting	13º Symposium of Bial Foudation – Behind and Beyond the Brain; The mystery of time Bial Foundation (Porto, Portugal)
2019/11/14	Regenerative Endodontics: in vivo model with Human Apical Papilla Cells	28º Congresso Ordem dos Médicos Dentistas OMD (Lisboa)
2019/09/05	In vivo Regenerative Potential of Human Apical Papilla Cells	Oral Health Conference CED-IADR/NOF (Madrid, Espanha)
2019/05/29	IL-4 skews the microglial developmental program during cerebellar maturation	IV Symposium Portuguese Glial Network Portuguese Glial Network (Lisbon, Portugal)
2018	Microglia morphology and density analysis: using stereology and 3D reconstruction to study the neuroimmune impact of early life stress	52º International Congress on Microscopy and Microanalysis (Coimbra, Portugal)
2017	Immune alterations in progranulin mutation carriers have functional consequences in NCL: data from human NCL models”, 13th International Symposium of the Portuguese Society for Metabolic Disorders, March, Évora, Portugal	13th International Symposium of the Portuguese Society for Metabolic Disorders (Évora, Portugal)
2016	MicroRNA contribution in a new therapeutic strategy for Alzheimer’s disease	The 2016 Alzheimer’s Disease Congress (Londres, Reino Unido)
2015	Lipid-based nanoparticles and their use in multimodal therapies towards glioblastoma	VIII Congress of the National Association of Neurooncology (Lisbon, Portugal)
2015	microRNAs and their therapeutical potential in Alzheimer's Disease	ENCODS 2015 - European Neuroscience Conference by Doctoral Students for Doctoral Students (Sesimbra, Portugal)
2015	The Role of miRNAs in neuroinflammation associated with Alzheimer’s disease	29º Encontro do Grupo de Estudos de Envelhecimento (Aveiro, Portugal)
2015	Dissecting the role of microRNAs and their therapeutic potential in Alzheimer’s disease	FEBS Young Scientists Forum (Berlim, Alemanha)
2014	MicroRNAs and their therapeutic potential in Alzheimer’s disease	World Forum of Young Scientists 2014 (Baku, Azerbaijão)
2013	Role of miR-21 in the regulation of microglia response to glioma	1st Research Coimbra (Coimbra, Portugal)
2012	Efficient siRNA delivery mediated by S413-PV cell penetrating peptide-based systems: a comparative study	13th Naples Workshop on Bioactive Peptides. Conformation and activity in peptides: Relationships and Interactions (Nápoles, Itália)
2012	MiR-155 silencing decreases neuroinflammation in Aß-stressed astrocytes and microglia cells	20th Congress of the European Society of Gene and Cell Therapy (Versailles, França)
2011	PDGF-mediated modulation of miRNAs in glioblastoma multiforme: a new paradigm in miRNA regulation in brain tumors	Portuguese Genetic Conferences (Coimbra, Portugal)
2009	Lipoplex-mediated siRNA and DNA delivery to the CNS	Nanomedicine Advanced Course, Molecular Medicine Institute (Lisbon, Portugal)
2009	Folate receptor-targeting delivery of lipid-based systems aiming at cancer gene therapy	GTRV- Summer School «Targeted Drug Delivery» (Lausanne, Suiça)
2008	S413-PV cell penetrating peptide associated with different cargos: assessment of delivery efficiency and internalization mechanisms	30th European Peptide Symposium (30EPS) - Cell-Penetrating Peptides Satellite Symposium (Helsinki, Finlândia)
2006	Gene silencing in the CNS: Tf-lipoplexes for neuronal siRNA delivery in vitro and in vivo	XV National Congress of Biochemistry (Aveiro, Portugal)
2005	Cationic Liposome-mediated In Vivo Gene Transfer to the CNS	XIV National Congress of Biochemistry (Vilamoura, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2022/09/01 - Atual	Exploring the pathophysiological mechanisms and new lines of treatment for Frontotemporal Dementia, employing immunocompetent brain organoids Orientador	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/12/01 - Atual	Does early-life stress impact microglia-mediated remodeling of inhibitory circuits and myelination in the mPFC? Orientador	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016/09/01 - 2022/01/31	Regenerative Endodontics: in vivo model with Human Apical Papilla Cells Coorientador	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra, Portugal
2019/09/01 - 2020/10/09	Dissecting the impact of early life stress in microglia: neuron dynamics in the medial prefrontal cortex Orientador	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2013 - 2019/10/18	On the persistence of therapy: The potential of miRNA modulation in Alzheimer’s disease Orientador	Envelhecimento e Doenças Crónicas (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09 - 2018/10	Long-term impact of early-life stress on adult social behaviour and pre-frontal cortical circuits Coorientador	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/09 - 2018/06	The impact of early life stress throughout life: maternal separation-induced changes in behavior and microglia morphology Orientador	Investigação Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09 - 2017/09	MiRNAs and risk gene interactions in Alzheimer's disease: from mechanisms to therapeutics Orientador	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09 - 2016/09	Role of miR-29b in the regulation of progranulin and dna methyltransferases 3A and 3B expression : therapeutic potential in glioblastoma Orientador	Bioquímica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2016	Inflammation in Alzheimer's disease: deregulation and modulation of miRNA expression in the mononuclear phagocyte system Orientador	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/09 - 2014/09	MiRNA Profilling and Modulation in Cancer Stem Cells isolated from Glioblastoma Orientador	Bioquímica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09 - 2014/09	Effect of Bexarotene and Aß in microglia and macrophage TREM2 expression and M1/M2 polarization Orientador	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09 - 2013/09	MiRNA contribution to APP metabolism and Aß production in Alzheimer’s disease: Identification of new miRNA-related SNPs in the 3’UTR of human APP and APOE genes Orientador	Bioquímica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09 - 2013/07	Role of miR-21 in the regulation of microglia immune response to glioma Orientador	Bioquímica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09 - 2013/07	The role of PDGF in the regulation of the intracellular pool of MMP-2: MMP-2 contribution to SNALP internalization in glioma cells Orientador	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/09 - 2011/07	Evaluation of miR-155 and miR-125b regulatory effect on astrocyte-mediated immune response Orientador	Bioquímica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2021/11/30 - 2021/11/30	V Symposium of the Portuguese Glial Network (2021/11/30 - 2021/11/30) Simpósio (Membro da Comissão Organizadora)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/10/14 - 2017/10/18	COST Action BM1402 training School – Principles of Drug Development, Novartis Campus, Switzerland (2017/10/14 - 2017/10/18) Oficina (workshop) (Coorganizador)	Novartis International AG, Suiça
2016/06/20 - 2016/06/23	Biological Markers in neurological diseases: present and future approaches” Advanced Course, JPND consortium BIOMARKAPD (2016/06/20 - 2016/06/23) Oficina (workshop) (Coorganizador)	Hospitais da Universidade de Coimbra, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2015/09 - Atual	Researcher's Night Exposição	Theater, Exhibition, Seminars CNC.IBILI, Portugal
2015/03/01 - Atual	Brain Awareness Week Outro	Visit to school CNC.IBILI, Portugal
2021/04/21 - 2021/04/26	Web Seminars directed towards the general public and students concerning the importance of vaccination: Conversas com Cientistas - Décadas de Ciência para Dias de Vacinas Conferência	Conversas com Cientistas - Décadas de Ciência para Dias de Vacinas Ciência Viva, Portugal
2019/11/28 - 2019/11/28	Participation as invited speaker in the event “Café da Ciência – O Cérebro: Presente, Passado e Futuro”, Semana da Ciência e Tecnologia, 2019. Conferência	Café da Ciência – O Cérebro: Presente, Passado e Futuro

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/03/25	Thioredoxin Reductase Inhibitors in anticancer therapy: Thimerosal Efficacy in Glioblastoma Arguente principal	Isabella Calvo Bramatti (Doutoramento) Universidade de Lisboa, Portugal
2023/11/08	"Deciphering the glial and synaptic changes under chronic alcohol exposure using a self-administration paradigm.” Arguente	Ana Margarida Bravo rodrigues (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2023/09/25	Dissecting the mechanisms underlying the anti-inflammatory effects of sitagliptin on microglial cells. Arguente principal	Cristiana Leote (Mestrado) Universidade de Coimbra Departamento de Física, Portugal
2023/09/20	“Duo therapeutic strategy: silencing ataxin-3 while co-expressing a homologous sequence” Arguente principal	João Lourenço (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/02/15	The role of a candidate microRNA in mitochondrial dysfunction and inflammatory responses in vitro: relevance to Parkinson’s disease Arguente principal	Beatriz da Silva Guedes (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/12/15	Assessing the role of the secretome of brain metastatic breast cancer cells in the phenotypic shift and oxidative response of microglia Arguente principal	Ana Filipa Domingues Laranjeiro (Mestrado) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/07/29	Influence of elevated hydrostatic pressure on Müller cells phenotype. Do microglia-derived microvesicles play a role? Arguente principal	Magda Ferreira-Rodrigues (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/12/16	MICRORNA PROFILING IN HUMAN CELL-BASED MODELS OF MACHADO-JOSEPH DISEASE Arguente principal	Maria Inês Nunes dos Santos (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/07/29	Alloparental Behavior: the effect of pup exposure on nest building and the role of serotonin Arguente principal	Catarina Pacheco (Mestrado) Universidade de Coimbra, Portugal
2018/07	Role of astrocytes in synaptic plasticity and memory in animal models of Alzheimer’s disease Arguente principal	Cátia Sofia Resende Lopes (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/06	Biocompatibility of new endodontic sealers Arguente principal	Joana Freitas (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2017	Role of glial cells as contributors to the onset and propagation of ALS disease Arguente principal	Joana Carolina Marinho Cunha (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/07	Dismorphic brain region regulation of microglia morphology and behavioural implication: focus on the crosstalk between glucocorticoids and A2A receptors Arguente principal	Joana Filipa Mendes Duarte (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07	miRNAs in the regulation of synaptic function Arguente principal	Beatriz Figueiredo Rodrigues (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016	Development of Monoolein-based lipofection vectors for therapeutic siRNA delivery Arguente principal	Ana Cristina Norberto Gonçalves de Oliveira (Doutoramento) Universidade do Minho, Portugal
2016	Inflammation in Alzheimer's disease: deregulation and modulation of miRNA expression in the mononuclear phagocyte system Orientador	Joana Ribeiro Guedes (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2015/07	GADD45ß: a novel long-term memory mediato Arguente principal	David Vilhena Catarino Brito (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/09	Activity-dependent changes in the dendritic distribution of hnRNP K: functional implications Arguente principal	Eduardo Firmino Morais (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09	BDNF-induced local protein synthesis at the synapse: a regulatory role for hnRNuPK Arguente principal	Luís Rodrigues (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09	Role of AKT-regulated miRNAs in Non-small cell lung cancer Arguente principal	Mafalda Raquel da Conceição Santos (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09	Role of miRNAs and BDNF in the modulation of hippocampal neuron morphology and antidepressants Arguente principal	Marta Costa Jordão (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2021/11/30 - 2021/11/30	V Symposium Portuguese Glial Network	CNC - University of Coimbra

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2023/03/06 - Atual	Neuroimmunology	Neuroimmunology (Mestrado)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2022/09 - Atual	Cellular Physiology	Biology (Licenciatura)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018/02 - Atual	Neuronal Circuits - Master in Cellular and Molecular Biology	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/02 - Atual	“Neuroepigenetics” Advanced Course of the Doctoral Program in Biology and Experimental Medicine, 3rd Cycle	Neuroepigenetics (Curso de doutoramento (conclusão de unidades curriculares))	CNC.IBILI, Portugal
2021/03/22 - 2021/03/26	Advanced Course - Synapse Structure and Function	Biologia Experimental e Biomedicina (Doutoramento)	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/07/05 - 2020/07/09	Advances in Neuropharmaceutics	Advances in Neuropharmaceutics (Pós-Graduação)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2021/08/06	Interview with Diário de Notícias concerning my career and recent work in the field of Dementia entitled: "O que é o microARN31 e como pode ser importante numa terapia para Alzheimer"	Diário de Notícias
2021/06/06	Illustrated Chronicle in Journal Público in A Saúde no Saber - O que é a perturbação de hiperactividade e défice de atenção? Serão só bichos-carpinteiros?	Público
2016/02/01	Estudo revela que falha de células imunitárias agrava doença de Alzheimer	Expresso

Entrevista / Programa (rádio / tv)

	Programa	Tema
2021/01/13 - Atual	90s of Science	miRNAs and Alzheimer's Disease
2022/03/24 - 2022/03/24	RUC - Semana Internacional do Cérebro	Cerebral Immunity
2021/05/06 - 2021/05/06	Estudo em Casa - Sciences class directed at 9º grade students on the topic of the adolescent brain	O cérebro Adolescente / The adolescent brain
2018/04/08 - 2018/04/08	MouseAGE ECR Case Study	Early Career Researchers discuss the benefits of MouseAGE

Distinções

Prémio

2019	Pfizer Award for Best Basic Research Publication of 2019 Pfizer AB, Suécia
2019	Honourable Mention in Basic Research

Outra distinção

2004	Merit Fellowship Universidade de Coimbra, Portugal