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João Lopes holds a Cell Biology PhD obtained in 2009 from University of Coimbra (Portugal), a 5-star QS Star Rating university, where he also graduated in Biology in 2003. During the PhD he was a visiting researcher at the University of California (Irvine, USA), under the supervision of Prof. Frank LaFerla, a world's top 2% most-cited scientist. In his PhD, João Lopes made important contributions to the study of Alzheimer's disease (AD) and Prion encephalopathies (PRE), being the first to uncover the role of cyclin-dependent kinase 5 on the hyperphosphorylation of tau, triggering of apoptosis and abortive cell cycle re-entry that occur analogously in the neurodegeneration associated to both disorders. Building on the acquired expertise, in 2010 he joined the D3- Drug Discovery and Development department at the Italian Institute of Technology (IIT, Genova, Italy), a top-50 research institution in Europe, as a post-doctoral researcher. At IIT, João Lopes explored the pharmacology behind the neuroprotective potential of two major anti-AD drugs, memantine and galantamine. Furthermore, he was part of the team involved in the development and testing of memoquin, a multi-target compound against AD. In 2012 he returned to Portugal and joined the Neuromodulation group (CNC/CIBB, Coimbra, Portugal), a leading group worldwide in the study of purinergic signaling in brain diseases headed by Prof. Rodrigo Cunha, another top 2% most cited scientist. First as a post-doc (supported by an FCT fellowship), from 2019 to 2023 hired as a Junior Researcher and presently as an Auxiliary Researcher (FCT’s 5th CEEC), he developed experimental work focused on the modulation of adenosine receptor activity as a neuroprotective mechanism against AD, although he also was involved in projects that addressed Parkinson's disease, Angelman syndrome and other brain disorders. João Lopes published 29 papers in international peer-reviewed journals (18 since 2018), and 2 book chapters. His h-index is 15, with the internationally refereed papers accumulating an impact factor of 141.7 and approximately 900 citations. João Lopes is 1st or corresponding author of 11 articles and senior author of 6 (5 within the last 2 years). Furthermore, over 80% of the publications were in journals within the first Quartile of their categories. From 2008 to 2009 he was Associate Editor of Journal of Alzheimer's Disease and is regularly invited as a reviewer by several high-impact international journals. His work has also been recognized through invited and selected oral presentations, having participated in international and national meetings both with oral and poster presentations. João Lopes supervised 1 graduation and 1 Master student and is currently the supervisor of a Master student and was tutor to several Medicine students (GAPI program). Since 2015 he lectured 9 classes to Master students at UC. João Lopes was the recipient of 2 FCT Fellowships (PhD Fellowship from 2005 to 2008 and Postdoc Fellowship from 2013 to 2019) and received 6 travel grants to participate in international meetings. He is accredited by DGAV as Coordinating Researcher (procedure and project design) for animal experimentation and has expertise in in vitro, ex-vivo and in vivo work, being proficient in electrophysiology, optogenetics, behavioral assessment, stereotaxic and peripheral administration of compounds, neuronal cell culture, cell viability assays, western blot, ELISA, immunocyto and immunohistochemistry, confocal and fluorescence microscopy, neuronal transfection, DNA and RNA extraction, PCR and agarose gel electrophoresis. His scientific areas of expertise are Adenosine research, Neurodegeneration, AD, Synaptic transmission and plasticity, Brain disorders and Pharmacology. Finally, it should be noted that his scientific activity was interrupted due to paternity in 2016 and 2018/19. Also, as consequence of a full proto-colectomy in July 2020 he was attributed a 60% disability quota.
Identificação

Identificação pessoal

Nome completo
João Pedro Oliveira da Silva Paulino Lopes

Nomes de citação

  • Lopes, João P.

Identificadores de autor

Ciência ID
5E1A-A059-E017
ORCID iD
0000-0002-5122-1802

Moradas

  • Centro de Neurociências e Biologia Celular. Departamento de Zoologia, Universidade de Coimbra, 3004-517, Coimbra, Coimbra, Portugal (Profissional)
  • Rua da Quinta, nº 25, 1º, 3130-080, Granja do Ulmeiro, Soure, Portugal (Pessoal)

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Italiano Utilizador proficiente (C1) Utilizador independente (B1) Utilizador elementar (A2) Utilizador proficiente (C2) Utilizador elementar (A2)
Francês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B1) Utilizador proficiente (C1) Utilizador elementar (A2)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador independente (B2) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador elementar (A2)
Formação
Grau Classificação
2012/05/01 - 2019/02/04
Concluído
Post-doctorate in Health Sciences (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/09/23 - 2013/10/04
Concluído
Course in Laboratory Animal Science (Outros)
Especialização em Category C
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Approved
2010/03/01 - 2012/04/30
Concluído
Post-doctorate in Pharmacology (Pós-doutoramento)
Istituto Italiano di Tecnologia, Itália
2005/01/01 - 2009/11/13
Concluído
Biology (Doutoramento)
Especialização em Cell Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Neurodegenerescência em Doença de Alzheimer e Encefalopatias Associadadas a Priões: Papel da Cinase Dependente de Ciclina 5 e dos Reguladores do Ciclo Celular" (TESE/DISSERTAÇÃO)
Aprovado com louvor e distinção por unanimidade
2003/10/01 - 2004/12/31
Concluído
Cell Biology (Curso de mestrado (conclusão do curso de especialização))
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
19
1998/09/01 - 2003/07/03
Concluído
Biology (Licenciatura)
Especialização em Scientific branch
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2023/07/31 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2019/02/05 - 2023/07/30 Investigador Contratado (Investigação) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2012/06/01 - 2019/02/04 Pós-doutorado (Investigação) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2010/03/01 - 2012/04/30 Investigador Contratado (Investigação) Istituto Italiano di Tecnologia, Itália
Istituto Italiano di Tecnologia, Itália
2006/10/02 - 2007/04/04 Investigador visitante (Investigação) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
University of California Irvine Institute for Memory Impairments and Neurological Disorders, Estados Unidos

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2005/01/01 - 2009/11/13 PhD (Research) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2003/10/01 - 2004/12/31 MSc (Research) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Projetos

Bolsa

Designação Financiadores
2018/05/01 - Atual Strategies for healthy aging
CENTRO-01-0246-FEDER-000010
Investigador
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Em curso
2018 - Atual Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress
Fundacion LaCaixa
Investigador
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia

Fundación La Caixa
Em curso
2018/07 - 2021/06 Recetores A2A da adenosina como desencadeadores de disfunção mnemónica na doença de Alzheimer: mecanismos e possibilidade terapêutica
Provided by PTCRIS: PTDC/MED-NEU/31274/2017
Fundação para a Ciência e a Tecnologia
2016/05 - 2019/07 Papel dos astrócitos no controlo da memória- foco nos recetores adenosina A2A
Provided by PTCRIS: PTDC/NEU-NMC/4154/2014
Fundação para a Ciência e a Tecnologia
2018/01/01 - 2019/06/30 Manipulation of A2A receptors to control symptoms of Angelman syndrome
---
Investigador
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação Amélia de Melo
Concluído
2013/01 - 2019/02 Tinkering with adenosine metabolism to manipulate adenosine neuromdulation and bolster neuroprotectin in brain disorders
Provided by PTCRIS: SFRH/BPD/85404/2012
Fundação para a Ciência e a Tecnologia
2016/10 - 2017/09 Adenosine A2A Receptor Antagonism Affords Integrated Benefits for Neurological Symptoms of Neurofibromatosis Type I
W81XWH-18-1-0532
Bolseiro de Pós-Doutoramento
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Congressionally Directed Medical Research Programs
Concluído
2012/05 - 2014/08 Papel fisio-patológico da ecto-5`-nucleotidase - um novo alvo para neuroprotecção
122005PRJ
Fundação para a Ciência e a Tecnologia
2011/08 - 2013/12 Localization and metabolism of APP controlling synaptic degeneration in animal models of Alzheimer's disease
Bolseiro de Pós-Doutoramento
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
2005/01 - 2008/12 NEURODEGENERATION IN ALZHEIMER´S DISEASE AND PRION RELATED ENCEPHALOPATHIES: THE ROLE OF CYCLIN-DEPENDENT KINASE 5 AND CELL CYCLE REGULATORS
Provided by PTCRIS: SFRH/BD/16381/2004
Fundação para a Ciência e a Tecnologia
2003/09/01 - 2004/12/31 A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies
POCTI/36101/NSE/1999
Bolseiro de Mestrado
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2023/07/31 - 2029/07/30 Harnessing the potential of VNUT modulation against memory dysfunction in Alzheimer's Disease
2022.05689.CEECIND/CP1714/CT0015
Investigador responsável
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/02/05 - 2023/07/30 Impact of purinergic neuromodulation in neurodegenerative brain pathologies
DL 57/2016/CP1448/CT0001
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2017 - Atual Study of caffeine derivatives in the inhibition of Alzheimer's disease and as a base for novel drugs
-
Investigador
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - Atual Causas e consequências da reactivação do ciclo celular nos neurónios: implicações na doença de Alzheimer e nas encefalopatias por priões
GAPI 01/08
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
Concluído
2007 - Atual Neuroinflamação associada à doenca de Alzheimer
GAPI 04/07
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
Concluído
2006 - Atual Degeneração neuronal associada à doenca de Alzheimer e às encefalopatias causadas por priões
GAI 05/06
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
Concluído
2005 - Atual Disfunção colinérgica na doença de Alzheimer: avaliação da capacidade neuroprotectora de compostos com acção antioxidante e inibidora das colinesterases
GAI 14/05
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Medicina, Portugal
Concluído
2004 - Atual O efeito de novos inibidores das colinesterases na neurotoxicidade do peptídeo beta amilóide. Potenciais agentes terapêuticos na doença de Alzheimer
GAI 05/04
Bolseiro de Mestrado
Universidade de Coimbra Faculdade de Medicina, Portugal
Concluído
2015/01/01 - 2017/06/30 The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer's disease
Mantero-Bellard Award
Investigador
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Santa Casa da Misericórdia de Lisboa
Concluído
Produções

Publicações

Artigo em conferência
  1. Lopes, João. "Abstracts from Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, held in Bonn, Germany, from July 23–27, 2014.". 2014.
Artigo em revista
  1. Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease". Biomolecules (2023): https://doi.org/10.3390/biom13081173.
    10.3390/biom13081173
  2. Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation". Biomolecules (2023): https://doi.org/10.3390/biom13040715.
    10.3390/biom13040715
  3. Cátia R. Lopes; Joana S. Silva; Joana Santos; Matilde S. Rodrigues; Daniela Madeira; Andreia Oliveira; Ana Moreira-de-Sá; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/8/6968.
    10.3390/ijms24086968
  4. Cátia R. Lopes; Andreia Oliveira; Ingride Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al. "Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas". Biomolecules (2023): https://www.mdpi.com/2218-273X/13/1/106.
    10.3390/biom13010106
  5. Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Cunha, R.A.. "CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity". International Journal of Molecular Sciences 23 21 (2022): 12826-12826. http://dx.doi.org/10.3390/ijms232112826.
    10.3390/ijms232112826
  6. Valada P; Hinz S; Vielmuth C; Lopes CR; Cunha RA; Müller CE; Lopes JP. "The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.". Purinergic signalling (2022): http://europepmc.org/abstract/med/36156760.
    10.1007/s11302-022-09899-7
  7. Valada P; Alçada-Morais S; Cunha RA; Lopes JP. "Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage.". International journal of molecular sciences (2022): http://europepmc.org/abstract/med/36142422.
    10.3390/ijms231810510
  8. Lopes, C.R.; Amaral, I.M.; Pereira, M.F.; Lopes, J.P.; Madeira, D.; Canas, P.M.; Cunha, R.A.; Agostinho, P.. "Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure". Journal of Neurochemistry 160 5 (2022): 556-567. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124559190&partnerID=MN8TOARS.
    10.1111/jnc.15575
  9. Pereira, Marlene F.; Amaral, Inês M.; Lopes, Cátia; Leitão, Catarina; Madeira, Daniela; Lopes, João P.; Gonçalves, Francisco Q.; et al. "l-a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory". The FASEB Journal 35 8 (2021): http://dx.doi.org/10.1096/fj.202100336r.
    10.1096/fj.202100336r
  10. Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas. "Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02275-9.
    10.1007/s12035-020-02275-9
  11. Fernandes, M.Y.D.; Dobrachinski, F.; Silva, H.B.; Lopes, J.P.; Gonçalves, F.Q.; Soares, F.A.A.; Porciúncula, L.O.; et al. "Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106020393&partnerID=MN8TOARS.
    10.1038/s41598-021-89964-0
  12. Lopes, João. "Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome.". Neurobiology of disease (2020): https://doi.org/10.1016/j.nbd.2020.105137.
    10.1016/j.nbd.2020.105137
  13. Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al. "Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine". Neurobiology of Disease 132 (2019): 104570. http://dx.doi.org/10.1016/j.nbd.2019.104570.
    10.1016/j.nbd.2019.104570
  14. João P. Lopes; Anna Pliássova; Rodrigo A. Cunha. "The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors". Biochemical Pharmacology 166 (2019): 313-321. https://doi.org/10.1016/j.bcp.2019.06.008.
    10.1016/j.bcp.2019.06.008
  15. João Pedro Lopes; Rodrigo A. Cunha. "What is the extracellular calcium concentration within brain synapses?". Journal of Neurochemistry 149 4 (2019): 435-437. https://doi.org/10.1111/jnc.14696.
    10.1111/jnc.14696
  16. Morató, X.; Gonçalves, F.Q.; Lopes, J.P.; Jauregui, O.; Soler, C.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F.. "Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice". Journal of Neurochemistry 148 6 (2019): 796-809. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060713664&partnerID=MN8TOARS.
    10.1111/jnc.14653
  17. Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q.; Pliássova, Anna V.; Machado, Nuno J.; Silva, Henrique B.; Canas, Paula M.; et al. "Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease". Neurobiology of Disease 117 (2018): 72-81. http://dx.doi.org/10.1016/j.nbd.2018.05.024.
    10.1016/j.nbd.2018.05.024
  18. Pliássova A; Lopes JP; Lemos C; Oliveira CR; Cunha RA; Agostinho P. "The Association of Amyloid-ß Protein Precursor With a- and ß-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.". (2016): http://europepmc.org/abstract/med/26497029.
    10.1007/s12035-015-9491-9
  19. Lopes, J.P.; Morató, X.; Souza, C.; Pinhal, C.; Machado, N.J.; Canas, P.M.; Silva, H.B.; et al. "The role of parkinson's disease-associated receptor GPR37 in the hippocampus: Functional interplay with the adenosinergic system". Journal of Neurochemistry (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928177504&partnerID=MN8TOARS.
    10.1111/jnc.13109
  20. Lopes, J.P.; Tarozzo, G.; Reggiani, A.; Piomelli, D.; Cavalli, A.. "Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity". Brain and Behavior 3 2 (2013): 67-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893466236&partnerID=MN8TOARS.
    10.1002/brb3.118
  21. Capurro, V.; Busquet, P.; Lopes, J.P.; Bertorelli, R.; Tarozzo, G.; Bolognesi, M.L.; Piomelli, D.; Reggiani, A.; Cavalli, A.. "Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874153672&partnerID=MN8TOARS.
    10.1371/journal.pone.0056870
  22. Lopes, J.P.; Agostinho, P.. "Cdk5: Multitasking between physiological and pathological conditions". Progress in Neurobiology 94 1 (2011): 49-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955109480&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2011.03.006
  23. Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Neurodegeneration in an Aß-induced model of Alzheimer's disease: The role of Cdk5". Aging Cell 9 1 (2010): 64-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249103674&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2009.00536.x
  24. Lopes, João P.; Oliveira, Catarina R.; Agostinho, Paula. "Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides". Cell Cycle 8 1 (2009): 97-104. http://dx.doi.org/10.4161/cc.8.1.7506.
    10.4161/cc.8.1.7506
  25. Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Cell cycle re-entry in Alzheimer's disease: A major neuropathological characteristic?". Current Alzheimer Research 6 3 (2009): 205-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149106183&partnerID=MN8TOARS.
    10.2174/156720509788486590
  26. Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; Laferla, F.M.. "Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-ß and tau pathology". Journal of Alzheimer's Disease 16 3 (2009): 541-549. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549145514&partnerID=MN8TOARS.
    10.3233/JAD-2009-0993
  27. Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides". Cell Cycle 8 1 (2009): 97-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749123603&partnerID=MN8TOARS.
  28. Agostinho, P.; Lopes, J.P.; Velez, Z.; Oliveira, C.R.. "Overactivation of calcineurin induced by amyloid-beta and prion proteins". Neurochemistry International 52 6 (2008): 1226-1233. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949104298&partnerID=MN8TOARS.
    10.1016/j.neuint.2008.01.005
  29. Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: Implications for Alzheimer's disease and prion-related encephalopathies". Cellular and Molecular Neurobiology 27 7 (2007): 943-957. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549015597&partnerID=MN8TOARS.
    10.1007/s10571-007-9224-3
  30. Santos, P.; Cunha, A.; Lopes, J.P.; Domingos, A.; Regateiro, F.; Segorbe-Luís, A.. "Perfil de expressão génica por PCR em tempo real em doentes VIH negativos com tuberculose multirresistente". Revista Portuguesa de Pneumologia 9 5 (2003): 444. http://dx.doi.org/10.1016/s0873-2159(15)30711-x.
    10.1016/s0873-2159(15)30711-x
Capítulo de livro
  1. Lopes, João. "Doenças de priões ou encefalopatias espongiformes". In Neurociências, 561-574. Portugal, 2017.
    Publicado
  2. Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; LaFerla, F.M.. "Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not aß and tau pathology". 2011.
    10.3233/978-1-60750-733-8-139
Poster em conferência
  1. Valada, Pedro; Hinz S; Vielmuth C; Cunha, Rodrigo A.; Müller CE; Lopes, João P.. "The impact of inosine on hippocampal synaptic transmission and plasticity involves adenosine released through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors". Trabalho apresentado em 8th European Synapse Meeting, 2022.
  2. Lopes, João P.; Cunha, Rodrigo A.. "Neuroprotective potential of theobromine against ß-amyloid-induced impairment of synaptic plasticity and neurotoxicity". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  3. Sá, Ana M; Gonçalves, Francisco Q; Lopes, João; Silva, Henrique B.; Tomé, Ângelo R.; Cunha, Rodrigo A; Canas, Paula M. "Pharmacological blockade of adenosine A2A receptors recovers motor learning and grip strength in an Angelman syndrome mouse model". Trabalho apresentado em 1st European Purine Meeting, 2019.
  4. Pereira, Malene; Amaral, Inês; Lopes, João; Lopes, Cátia; Leitão, Catarina; Cunha, Rodrigo A.; Agostinho, Paula. "Pharmacological approaches to imping astrocytic function: impact on mouse Hippocampal LTP". Trabalho apresentado em 11th FENS Forum of Neuroscience in Berlin, 2018.
  5. Lopes, João; Gonçalves, Nélio. "The blockade of neuronal A2A adenosine receptors prevents impairment by ß-amyloid peptides of hippocampal synaptic plasticity.". Trabalho apresentado em XV Annual Meeting of the Portuguese Society for Neuroscience, 2017.
  6. Lopes, João. "The blockade of neuronal A2A adenosine receptors prevents impairment by beta amyloid peptides of hippocampal synaptic plasticity". Trabalho apresentado em 17th Meeting of the Portuguese Society for Neuroscience, 2017.
  7. Lopes, João; Gonçalves, Francisco Q; Silva, Henrique B.; Silva, António C; Lemos, Cristina; Gonçalves, Nélio; Oliveira, Catarina R; Agostinho, Paula; Cunha, Rodrigo A.. "ATP-derived adenosine controls Aß-induced impairment of behaviour and synaptic plasticity". Trabalho apresentado em 7th ISN Special Neurochemistry Conference on Synaptic Function and Dysfunction in Brain Diseases, 2016.
  8. Lopes, João. "Adenosine A2A receptor critically control the impairment caused by beta amyloid peptides of synaptic plasticity in mouse hippocampal slices". Trabalho apresentado em 15th Meeting of the Portuguese Society for Neuroscience, 2015.
  9. Canas, Paula M.; Rial, Daniel; Simões, Ana P.; Lopes, João; Silva, Henrique B.; Machado, Nuno J.; Queiroz, Francisco; et al. "Synaptic and glia involvement in the purinergic control of neurodegenerative diseases". Trabalho apresentado em Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, 2014.
    10.1007/s11302-014-9430-7
  10. Lopes, João; Silva, Henrique B.; Oliveira, Catarina R; Agostinho, P; Cunha, Rodrigo A. "Adenosine A2A receptor blockade and ecto-5’-nucleotidase inhibition abrogate the Aß1-42-induced impairment of mouse hippocampal LTP". Trabalho apresentado em 9th FENS Forum of Neuroscience, 2014.
  11. Lopes, João. "The amyloid beta (1-42)-induced impairment of mouse hippocampal LTP is abrogated by adenosine A2A receptor blockade and ecto-5’-nucleotidase inhibition". Trabalho apresentado em XLIV Meeting of the Portuguese Pharmacology Society, 2014.
  12. Lopes, João. "The beta amyloid (1-42) peptide-induced impairment of hippocampal LTP is eliminated in adenosine A2A receptor knock-out mice". Trabalho apresentado em 13th Meeting of the Portuguese Society for Neuroscience, 2013.
  13. Lopes, João; Blurton-Jones, Mathew; Yamazaki, Tritia R; Agostinho, Paula. "Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not Aß and tau pathology". Trabalho apresentado em Neuroscience 2008, 38th Annual Meeting of the Society for Neuroscience, 2008.
  14. Lopes, João; Oliveira, Catarina R; Agostinho, Paula. "Neurodegeneration in Alzheimer's disease and Prion-Related Encephalopathies: the role of cyclin-dependent kinase 5". Trabalho apresentado em 4th Training Course of Neuronal plasticity and neurodegenerative disorders: dysfunction and treatment, 2008.
  15. Lopes, João. "Cdk5 as a mediator in neuronal cell cycle reentry in Alzheimer’s Disease and Prion Related Encephalopathies". Trabalho apresentado em 6th FENS Forum, Geneva, Switzerland, 2008.
  16. Lopes, João. "Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not Abeta and tau pathology". Trabalho apresentado em 38th Annual Meeting of the Society for Neuroscience, Washington, 2008.
  17. Lopes, João; Oliveira, Catarina R; Agostinho, Paula. "Influence of cyclin-dependent kinase 5 in the neurodegenerative process of Alzheimer's Disease and Prion-Related Encephalopathies". Trabalho apresentado em 5th FENS Forum Vienna, 2006.
  18. Lopes, João; Oliveira, Catarina R; Agostinho, Paula. "Influence of Cdk5 in the neurotoxicity induced by amyloid-beta and prion peptides". Trabalho apresentado em FEBS Spetses Summer School, 2005.
  19. Lopes, João. "Influence of Cdk5 in the neurotoxicity induced by amyloid beta and prion peptides". Trabalho apresentado em 9th Meeting of the Portuguese Society for Neuroscience, 2005.
  20. Lopes, João. "Influence of Cdk5 in the neurotoxicity induced by amyloid beta and prion peptides". Trabalho apresentado em FENS Summer School, Ofir, 2005.
  21. Santos, P; Lopes, J; Gomes, JM; Pereira, L; Freitas, A; Domingos, A; Regateiro, F; Segorbe-Luís, A. "Mannan-binding lectin (MBL) polymorphisms and protein levels in pulmonary tuberculosis". Trabalho apresentado em 18th European Immunogenetics and Histocompatibility Conference, Sofia, Bulgary, 2004.
    10.1038/sj.gene.6364083
  22. Santos, P; Almeida, A; Lopes, J; Domingos, A; Regateiro, F; Segorbe-Luís, A. "Gene expression profile of co-stimulatory receptors, chemokines and cytokines using real-time PCR analysis in multidrug-resistant tuberculosis". Trabalho apresentado em 18th European Immunogenetics and Histocompatibility Conference, Sofia, Bulgary, 2004.
    10.1038/sj.gene.6364089
  23. Garção, P; Lopes, João; Oliveira, Catarina R.; Agostinho, Paula. "Neuroinflammation associated to Alzheimer's Disease and Prion-Related Encephalopathies". Trabalho apresentado em Research course "New molecular strategies to treat neurodegenerative diseases" sponsored by FEBS, Ofir, Portugal, 2004.
  24. Lopes, João. "The role of microglia in neurodegeneration associated to Alzheimers Disease and Prion-Related Encephalopathies". Trabalho apresentado em 18ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência, 2004.
  25. Santos, P; Lopes, J; Gomes, JM; Pereira, L; Freitas, A; Domingos, A; Regateiro, F; Segorbe-Luís, A. "Mannan-binding lectin (MBL) deficiency and protection of Mycobacterium tuberculosis infected individuals from progression to pulmonary disease". Trabalho apresentado em 9th European Complement Workshop, Trieste, Italy, 2003.
    10.1016/s0161-5890(03)00115-9
Resumo em conferência
  1. Lopes, João; Oliveira, Catarina R.; Agostinho, Paula. "Role of cyclin-dependent kinase 5 in the neurodegenerative process of Alzheimer's disease and prion-related encephalopathies". Trabalho apresentado em 21st Biennial Meeting of the International-Society-for-Neurochemistry/38th Annual Meeting of the American-Society-for-Neurochemistry, 2007.
    10.1111/j.0022-3042.2007.04723.x
Tese / Dissertação
  1. Lopes, João. "Neurodegeneration associated to Alzheimer's Disease and Prion-Related Encephalopathies: role of cyclin-dependent kinase 5 and the cell cycle regulators". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/02/07 Neuroprotective potential of theobromine against beta-amyloid-induced impairment of synaptic plasticity and neurotoxicity L Meeting of the Portuguese Pharmacology Society
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/09/04 ATP-derived adenosine controls synaptic and memory dysfunction in ß-amyloid models of Alzheimer's disease 1st European Purine Meeting
(Santiago de Compostela, Espanha)
2017/02 The blockade of neuronal A2A adenosine receptors prevents impairment by ß-amyloid of hippocampal synaptic plasticity XLVII Meeting of the Portuguese Pharmacology Society
Portuguese Pharmacology Society (Coimbra, Portugal)
2008/08/01 Neurodegeneration in Alzheimer’s disease and Prion-Related Encephalopathies: the role of cyclin-dependent kinase 5 4th Training Course of Neuronal plasticity and neurodegenerative disorders: dysfunction and treatment
FENS (Innsbruck, Áustria)
2007/08 Role of cyclin-dependent kinase 5 in the neurodegenerative process of Azheimer’s Disease and Prion-Related Encephalopathies 21st Biennial Meeting of the International Society for Neurochemistry
ISN/ASN (Cancun, México)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2022/09/19 - Atual Alterations in synaptic plasticity and memory in aging and Alzheimer's disease: the role of A2A receptors
Orientador
Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/02/01 - 2016/07/31 Role of Astrocytes in Synaptic Transmission and Plasticity
Orientador
Bioquímica (Outra)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2017 - Atual 17th Meeting of the Portuguese Society for Neuroscience
Encontro
17th Meeting of the Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurociências, Portugal
2017 - Atual XLVII Meeting of the Portuguese Pharmacology Society
Encontro
XLVII Meeting of the Portuguese Pharmacology Society
Sociedade Portuguesa de Farmacologia, Portugal
2015 - Atual 15th Meeting of the Portuguese Society for Neuroscience
Encontro
15th Meeting of the Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurociências, Portugal
2014 - Atual XLIV Meeting of the Portuguese Pharmacology Society
Encontro
XLIV Meeting of the Portuguese Pharmacology Society
Sociedade Portuguesa de Farmacologia, Portugal
2013 - Atual 13th Meeting of the Portuguese Society for Neuroscience
Encontro
13th Meeting of the Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurociências, Portugal
2005 - Atual 9th Meeting of the Portuguese Society for Neuroscience
Encontro
9th Meeting of the Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurociências, Portugal
2023/08/05 - 2023/08/06 ISN Satellite Workshop on Astrocytic Control of Brain Circuits and Behavior
Oficina (workshop)
ISN Satellite Workshop on Astrocytic Control of Brain Circuits and Behavior
International Society for Neurochemistry, Suiça

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022/10/21 - 2022/10/22 8th European Synapse Meeting
Encontro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2019 - 2019 1st European Purines Meeting, Santiago de Compostela, Spain, 2019
Congresso
1st European Purines Meeting
2019 - 2019 3rd Spanish and Portuguese Advanced Optical Microscopy Meeting, Coimbra, Portugal
Congresso
3rd Spanish and Portuguese Advanced Optical Microscopy Meeting
2016 - 2016 7th ISN Special Neurochemistry Conference on Synaptic Function and Dysfunction in Brain Diseases, Coimbra
Congresso
7th ISN Special Neurochemistry Conference on Synaptic Function and Dysfunction in Brain Diseases
International Society for Neurochemistry, Suiça
2014 - 2014 9th FENS Forum of Neuroscience, Milan, Italy
Congresso
9th FENS Forum of Neuroscience
Federation of European Neuroscience Societies, Bélgica
2010 - 2010 Seminar “Primary cells, cell culture and mycoplasma prevention”, Padova,Italy
Seminário
Seminar “Primary cells, cell culture and mycoplasma prevention”
Istituto Italiano di Tecnologia, Itália
2008 - 2008 4th Neurotrain Event of the Neuroscience Training in Europe “Neuronal plasticity and neurodegenerative disorders: Dysfunction andtreatment”, Innsbruck-Igls, Austria
Congresso
4th Neurotrain Event of the Neuroscience Training in Europe
Federation of European Neuroscience Societies, Bélgica
2008 - 2008 6th FENS Forum of European Neuroscience, Geneva, Switzerland
Congresso
6th FENS Forum
Federation of European Neuroscience Societies, Bélgica
2008 - 2008 38th annual meeting of the Society for Neuroscience,Washington, USA
Congresso
38th annual meeting of the Society for Neuroscience
Society for Neuroscience, Estados Unidos
2007 - 2007 21st Biennial Meeting of the International Society for Neurochemistry, Cancun, Mexico, 2007
Congresso
21st Biennial Meeting of the International Society for Neurochemistry
International Society for Neurochemistry, Suiça
2006 - 2006 5th FENS Forum of European Neuroscience, Vienna, Austria
Congresso
5th FENS Forum
Federation of European Neuroscience Societies, Bélgica
2005 - 2005 FEBS Summer School, Spetses, Greece
Congresso
FEBS Summer School, Spetses
Federation of European Biochemical Societies, Reino Unido
2005 - 2005 FENS Summer School, Ofir, Portugal
Congresso
FENS Summer School, Ofir
Federation of European Neuroscience Societies, Bélgica
2004 - 2004 Research course "New molecular strategies to treat neurodegenerative diseases" sponsored by FEBS, Ofir, Portugal
Congresso
Research course "New molecular strategies to treat neurodegenerative diseases"
Federation of European Biochemical Societies, Reino Unido
2004 - 2004 Workshop on Ageing, organized by the Institute for Interdisciplinary Research, Coimbra, Portugal
Oficina (workshop)
Workshop on Ageing
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2004 - 2004 18th meeting of the Group of Studies on Brain Aging and Dementia, Óbidos, Portugal
Congresso
18th meeting of the Group of Studies on Brain Aging and Dementia
GEECD - Grupo de Estudos de Envelhecimento Cerebral e Demência, Portugal
2002 - 2002 Albert Netter Journeys on "Genetics and Biotechnology in Ginecology"
Congresso
Albert Netter Journeys on “Genetics and Biotechnology in Ginecology”
Universidade de Coimbra, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024/01/30 - 2024/01/30 Synaptic function, neurophysiology and cognition - behavioral assessment of memories in animal models Neurociências Molecular e de Translação (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2023/03/28 - 2023/03/28 Molecular features & therapeutic opportunities to control memory dysfunction Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2023/01/03 - 2023/01/03 Synaptic function, neurophysiology and cognition - Behavioral assessment of memories in animal models Neurociências Molecular e de Translação (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2022/10/19 - 2022/10/19 Biological Models in Neurobiology Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2022/04/05 - 2022/04/05 Neurologic and memory function alterations - behavior, electrophysiology, neurochemistry and therapeutic opportunities Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/11/24 - 2021/11/24 Synaptic function, neurophysiology and cognition - Behavioral assessment of memories in animal models Neurociências Molecular e de Translação (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/04/06 - 2021/04/06 Neurologic and memory function alterations - behavior, electrophysiology, neurochemistry and therapeutic opportunities Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/01/11 - 2021/01/15 Neurophysiology and cognition - Synaptic plasticity Neurociências Molecular e de Translação (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/10/28 - 2015/10/28 Technologies in Neurobiology Research Biomedical Engineering (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2024/02/25 - Atual European Journal of Pharmacology (1879-0712) Elsevier
2024/02/24 - Atual Biochemical Pharmacology (0006-2952) Elsevier
2024/01/24 - 2024/02/21 Alzheimer's Research & Therapy (1758-9193) Springer Nature
2019/09/17 - 2019/12/17 Aging Cell (1474-9728) Wiley (Blackwell Publishing)
2018/07/22 - 2018/11/10 Aging Cell (1474-9728) Wiley (Blackwell Publishing)
2017/11/07 - 2017/11/27 Alzheimer's & Dementia (1552-5260) Elsevier
2014/05/28 - 2014/06/21 Journal of Neuroscience Research (1097-4547) Wiley (John Wiley & Sons)

Tutoria

Tópico Nome do aluno
2014/04/28 - 2014/05/20 Hippocampal synaptic plasticity in AD Inês Barreiros
2008 - 2008 Laboratory practices Students from the Faculty of Medicine of the University of Coimbra
2007 - 2007 Laboratory practices Sstudents from the Faculty of Medicine of the University of Coimbra
2006 - 2006 Laboratory practices Students from the Faculty of Medicine of the University of Coimbra
2005 - 2005 Laboratory practices Students from the Faculty of Medicine of the University of Coimbra
2004 - 2004 Laboratory practices Students from the Faculty of Medicine of the University of Coimbra
Distinções

Prémio

2017 Grant for participation in the 17th Meeting of the Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurociências, Portugal

Outra distinção

2008 Grant for the attendance of the “4th Training Course of Neuronal plasticity and neurodegenerative disorders: dysfunction and treatment”, Innsbruck, Austria
Federation of European Neuroscience Societies, Bélgica
2008 Grant for the attendance of the “6th FENS Forum”, Geneva, Switzerland
Sociedade Portuguesa de Neurociências, Portugal
2008 Grant for the attendance of the “Neuroscience 2008, 38th Annual Meeting of the Society for Neuroscience”, Washington, USA
Sociedade Portuguesa de Bioquímica, Portugal
2007 Grant for the attendance of the “21st Biennial Meeting of the International Society for Neurochemistry”, Cancun, Mexico, 2007
International Society for Neurochemistry, Suiça
2005 Grant for the attendance of “FEBS/EMBO Summer School”, Spetses, Greece
Federation of European Biochemical Societies, Reino Unido